locus-tag	class	description
K6V30_RS00095	COG4227	nucleotidyltransferase activity
K6V30_RS00190	COG0739	heme binding
K6V30_RS00190	COG0741	lytic transglycosylase activity
K6V30_RS00190	COG1196	nuclear chromosome segregation
K6V30_RS00230	COG0776	regulation of translation
K6V30_RS00295	COG3177	Filamentation induced by cAMP protein fic
K6V30_RS00300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6V30_RS00315	COG1192	Involved in chromosome partitioning
K6V30_RS00385	COG0739	heme binding
K6V30_RS00385	COG0741	lytic transglycosylase activity
K6V30_RS00385	COG1196	nuclear chromosome segregation
K6V30_RS00435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6V30_RS00440	COG0778	Nitroreductase
K6V30_RS00450	COG1640	4-alpha-glucanotransferase
K6V30_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6V30_RS00485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V30_RS00490	COG0318	PFAM AMP-dependent synthetase and ligase
K6V30_RS00525	COG0359	binds to the 23S rRNA
K6V30_RS00530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6V30_RS00535	COG0360	Binds together with S18 to 16S ribosomal RNA
K6V30_RS00560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V30_RS00565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6V30_RS00600	COG2431	L-lysine efflux transmembrane transporter activity
K6V30_RS00605	COG1193	negative regulation of DNA recombination
K6V30_RS00630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K6V30_RS00675	COG2234	aminopeptidase activity
K6V30_RS00695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6V30_RS00700	COG0802	atpase or kinase
K6V30_RS00715	COG0714	Associated with various cellular activities
K6V30_RS00755	COG3118	belongs to the thioredoxin family
K6V30_RS00765	COG0688	phosphatidylethanolamine metabolic process
K6V30_RS00770	COG1183	phosphatidylcholine synthase activity
K6V30_RS00790	COG0792	nuclease activity
K6V30_RS00815	COG0534	Mate efflux family protein
K6V30_RS00820	COG0528	UMP kinase activity
K6V30_RS00825	COG1621	beta-fructofuranosidase activity
K6V30_RS00835	COG1070	Carbohydrate kinase
K6V30_RS00865	COG0561	phosphatase activity
K6V30_RS00870	COG1629	transport
K6V30_RS00890	COG0233	cytoplasmic translational termination
K6V30_RS00895	COG1162	GTPase activity
K6V30_RS00915	COG4771	TonB-dependent receptor
K6V30_RS00920	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K6V30_RS00925	COG1131	(ABC) transporter
K6V30_RS00930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K6V30_RS00945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6V30_RS00965	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V30_RS00965	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V30_RS00975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6V30_RS00985	COG1629	transport
K6V30_RS00985	COG4206	TonB-dependent receptor
K6V30_RS01005	COG1629	transport
K6V30_RS01005	COG4206	TonB-dependent receptor
K6V30_RS01010	COG4974	Belongs to the 'phage' integrase family
K6V30_RS01015	COG4771	TonB-dependent receptor
K6V30_RS01030	COG2095	MarC family integral membrane protein
K6V30_RS01045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6V30_RS01055	COG1435	thymidine kinase activity
K6V30_RS01060	COG0628	permease
K6V30_RS01150	COG0740	serine-type endopeptidase activity
K6V30_RS01155	COG3415	Transposase
K6V30_RS01170	COG4383	Mu-like prophage protein gp29
K6V30_RS01360	COG0546	phosphoglycolate phosphatase activity
K6V30_RS01390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6V30_RS01415	COG1396	sequence-specific DNA binding
K6V30_RS01425	COG4771	TonB-dependent receptor
K6V30_RS01435	COG4771	TonB-dependent receptor
K6V30_RS01515	COG0534	Mate efflux family protein
K6V30_RS01535	COG1522	sequence-specific DNA binding
K6V30_RS01560	COG3292	Two component regulator propeller
K6V30_RS01560	COG0745	RESPONSE REGULATOR receiver
K6V30_RS01560	COG2205	protein histidine kinase activity
K6V30_RS01570	COG1629	transport
K6V30_RS01610	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
K6V30_RS01620	COG0252	asparaginase activity
K6V30_RS01625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6V30_RS01630	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K6V30_RS01640	COG4771	TonB-dependent receptor
K6V30_RS01660	COG0826	peptidase U32
K6V30_RS01665	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6V30_RS01685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6V30_RS01705	COG0519	Catalyzes the synthesis of GMP from XMP
K6V30_RS01710	COG5002	protein histidine kinase activity
K6V30_RS01715	COG2205	protein histidine kinase activity
K6V30_RS01725	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K6V30_RS01735	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K6V30_RS01750	COG3387	PFAM Glycoside hydrolase 15-related
K6V30_RS01790	COG3250	beta-galactosidase activity
K6V30_RS01800	COG2204	response regulator
K6V30_RS01805	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6V30_RS01830	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V30_RS01835	COG0737	Belongs to the 5'-nucleotidase family
K6V30_RS01840	COG0737	Belongs to the 5'-nucleotidase family
K6V30_RS01875	COG0335	large ribosomal subunit rRNA binding
K6V30_RS01880	COG4680	protein conserved in bacteria
K6V30_RS01890	COG1940	carbohydrate kinase activity
K6V30_RS01895	COG1136	(ABC) transporter
K6V30_RS01895	COG0577	efflux transmembrane transporter activity
K6V30_RS01900	COG1136	(ABC) transporter
K6V30_RS01900	COG0577	efflux transmembrane transporter activity
K6V30_RS01905	COG1136	(ABC) transporter
K6V30_RS01905	COG0577	efflux transmembrane transporter activity
K6V30_RS01910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS01920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6V30_RS01920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6V30_RS01930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6V30_RS01950	COG2996	Protein conserved in bacteria
K6V30_RS01955	COG0039	L-malate dehydrogenase activity
K6V30_RS01965	COG2217	Heavy metal translocating P-type atpase
K6V30_RS01985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6V30_RS01990	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6V30_RS01995	COG0509	glycine decarboxylation via glycine cleavage system
K6V30_RS02010	COG0006	proline dipeptidase activity
K6V30_RS02015	COG3250	beta-galactosidase activity
K6V30_RS02020	COG3408	Glycogen debranching enzyme
K6V30_RS02025	COG3458	cephalosporin-C deacetylase activity
K6V30_RS02040	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6V30_RS02060	COG4771	TonB-dependent receptor
K6V30_RS02075	COG1773	rubredoxin
K6V30_RS02085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6V30_RS02090	COG1011	Hydrolase
K6V30_RS02095	COG0196	riboflavin kinase activity
K6V30_RS02100	COG1266	CAAX protease self-immunity
K6V30_RS02110	COG3655	Transcriptional regulator
K6V30_RS02115	COG2166	iron-sulfur cluster assembly
K6V30_RS02120	COG2234	aminopeptidase activity
K6V30_RS02125	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6V30_RS02135	COG0280	phosphate acetyltransferase
K6V30_RS02140	COG3426	butyrate kinase activity
K6V30_RS02155	COG1185	polyribonucleotide nucleotidyltransferase activity
K6V30_RS02165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6V30_RS02185	COG1595	DNA-templated transcription, initiation
K6V30_RS02190	COG0076	glutamate decarboxylase activity
K6V30_RS02195	COG2066	Belongs to the glutaminase family
K6V30_RS02205	COG0531	amino acid
K6V30_RS02210	COG0784	Response regulator, receiver
K6V30_RS02210	COG2205	protein histidine kinase activity
K6V30_RS02315	COG0667	Aldo Keto reductase
K6V30_RS02320	COG3250	beta-galactosidase activity
K6V30_RS02350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS02360	COG1309	transcriptional regulator
K6V30_RS02365	COG2986	histidine ammonia-lyase
K6V30_RS02375	COG1228	amidohydrolase
K6V30_RS02385	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6V30_RS02395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V30_RS02410	COG0203	ribosomal protein L17
K6V30_RS02415	COG0202	RNA polymerase activity
K6V30_RS02420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6V30_RS02425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6V30_RS02430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6V30_RS02435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6V30_RS02440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6V30_RS02455	COG0200	Binds to the 23S rRNA
K6V30_RS02460	COG1841	ribosomal large subunit assembly
K6V30_RS02465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6V30_RS02470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6V30_RS02475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6V30_RS02480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6V30_RS02485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6V30_RS02490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6V30_RS02495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6V30_RS02500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6V30_RS02505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6V30_RS02510	COG0255	Belongs to the universal ribosomal protein uL29 family
K6V30_RS02515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6V30_RS02520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6V30_RS02525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6V30_RS02530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6V30_RS02535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6V30_RS02540	COG0089	rRNA binding
K6V30_RS02545	COG0088	Forms part of the polypeptide exit tunnel
K6V30_RS02550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6V30_RS02555	COG0051	transcription antitermination factor activity, RNA binding
K6V30_RS02560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V30_RS02565	COG0049	tRNA binding
K6V30_RS02570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K6V30_RS02580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6V30_RS02585	COG0085	RNA polymerase activity
K6V30_RS02590	COG0222	ribosome binding
K6V30_RS02595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6V30_RS02600	COG0081	regulation of translation
K6V30_RS02605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6V30_RS02615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6V30_RS02625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6V30_RS02655	COG4974	Belongs to the 'phage' integrase family
K6V30_RS02660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6V30_RS02665	COG0006	proline dipeptidase activity
K6V30_RS02665	COG0006	proline dipeptidase activity
K6V30_RS02670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6V30_RS02685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V30_RS02695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6V30_RS02705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6V30_RS02720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V30_RS02730	COG1027	Aspartate ammonia-lyase
K6V30_RS02735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6V30_RS02740	COG0252	asparaginase activity
K6V30_RS02805	COG2815	serine threonine protein kinase
K6V30_RS02805	COG0515	serine threonine protein kinase
K6V30_RS02820	COG2815	serine threonine protein kinase
K6V30_RS02820	COG0515	serine threonine protein kinase
K6V30_RS02870	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K6V30_RS02870	COG0662	Cupin 2, conserved barrel domain protein
K6V30_RS02875	COG0318	PFAM AMP-dependent synthetase and ligase
K6V30_RS02880	COG1396	sequence-specific DNA binding
K6V30_RS02890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6V30_RS02895	COG1217	gtp-binding protein TYPA
K6V30_RS02910	COG2059	Chromate
K6V30_RS02915	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6V30_RS02920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6V30_RS02960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K6V30_RS02965	COG2205	protein histidine kinase activity
K6V30_RS02965	COG3850	Histidine kinase
K6V30_RS02965	COG4999	Histidine kinase
K6V30_RS02965	COG3437	response regulator, receiver
K6V30_RS02970	COG0793	Belongs to the peptidase S41A family
K6V30_RS02990	COG4948	Mandelate Racemase Muconate Lactonizing
K6V30_RS03000	COG0483	inositol monophosphate 1-phosphatase activity
K6V30_RS03010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6V30_RS03050	COG1629	transport
K6V30_RS03050	COG4206	TonB-dependent receptor
K6V30_RS03055	COG0561	phosphatase activity
K6V30_RS03070	COG3634	alkyl hydroperoxide reductase activity
K6V30_RS03080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6V30_RS03085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6V30_RS03090	COG2816	NAD+ diphosphatase activity
K6V30_RS03105	COG1629	transport
K6V30_RS03105	COG4206	TonB-dependent receptor
K6V30_RS03215	COG3292	Two component regulator propeller
K6V30_RS03215	COG3292	Two component regulator propeller
K6V30_RS03215	COG2205	protein histidine kinase activity
K6V30_RS03215	COG0745	RESPONSE REGULATOR receiver
K6V30_RS03215	COG0745	RESPONSE REGULATOR receiver
K6V30_RS03215	COG2205	protein histidine kinase activity
K6V30_RS03230	COG0018	arginyl-trna synthetase
K6V30_RS03240	COG0705	Rhomboid family
K6V30_RS03255	COG0339	signal peptide processing
K6V30_RS03260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6V30_RS03270	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6V30_RS03270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6V30_RS03275	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6V30_RS03280	COG1162	GTPase activity
K6V30_RS03295	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6V30_RS03300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6V30_RS03320	COG4974	Belongs to the 'phage' integrase family
K6V30_RS03335	COG0606	chelatase, subunit chli
K6V30_RS03345	COG2198	Histidine kinase
K6V30_RS03345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V30_RS03345	COG2205	protein histidine kinase activity
K6V30_RS03345	COG0784	Response regulator, receiver
K6V30_RS03355	COG3250	beta-galactosidase activity
K6V30_RS03380	COG3250	beta-galactosidase activity
K6V30_RS03410	COG0702	epimerase
K6V30_RS03415	COG4771	TonB-dependent receptor
K6V30_RS03425	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V30_RS03485	COG0673	inositol 2-dehydrogenase activity
K6V30_RS03495	COG0673	inositol 2-dehydrogenase activity
K6V30_RS03500	COG3292	Two component regulator propeller
K6V30_RS03500	COG0745	RESPONSE REGULATOR receiver
K6V30_RS03500	COG2205	protein histidine kinase activity
K6V30_RS03525	COG3209	COG3209 Rhs family protein
K6V30_RS03540	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS03565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6V30_RS03565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6V30_RS03580	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS03590	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS03620	COG1595	DNA-templated transcription, initiation
K6V30_RS03630	COG4771	TonB-dependent receptor
K6V30_RS03635	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V30_RS03660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6V30_RS03665	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS03670	COG1216	Glycosyl transferase, family 2
K6V30_RS03720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6V30_RS03725	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V30_RS03730	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V30_RS03765	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V30_RS03780	COG4771	TonB-dependent receptor
K6V30_RS03785	COG0561	phosphatase activity
K6V30_RS03830	COG4206	TonB-dependent receptor
K6V30_RS03830	COG1629	transport
K6V30_RS03835	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V30_RS03840	COG1595	DNA-templated transcription, initiation
K6V30_RS03855	COG4206	TonB-dependent receptor
K6V30_RS03855	COG1629	transport
K6V30_RS03870	COG1629	transport
K6V30_RS03910	COG4771	TonB-dependent receptor
K6V30_RS03925	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V30_RS03930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6V30_RS03950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6V30_RS03955	COG0793	Belongs to the peptidase S41A family
K6V30_RS03955	COG3409	Peptidoglycan-binding domain 1 protein
K6V30_RS03995	COG4771	TonB-dependent receptor
K6V30_RS04000	COG0745	RESPONSE REGULATOR receiver
K6V30_RS04000	COG2205	protein histidine kinase activity
K6V30_RS04000	COG3292	Two component regulator propeller
K6V30_RS04015	COG3119	arylsulfatase activity
K6V30_RS04035	COG1053	succinate dehydrogenase
K6V30_RS04040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6V30_RS04045	COG3119	arylsulfatase activity
K6V30_RS04085	COG3345	alpha-galactosidase
K6V30_RS04090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6V30_RS04090	COG0758	DNA mediated transformation
K6V30_RS04100	COG0826	peptidase U32
K6V30_RS04105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6V30_RS04160	COG0557	exoribonuclease II activity
K6V30_RS04190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6V30_RS04195	COG1917	Cupin 2, conserved barrel domain protein
K6V30_RS04200	COG1621	beta-fructofuranosidase activity
K6V30_RS04230	COG0702	epimerase
K6V30_RS04235	COG4771	TonB-dependent receptor
K6V30_RS04245	COG2814	Major facilitator Superfamily
K6V30_RS04250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS04280	COG4771	TonB-dependent receptor
K6V30_RS04285	COG3292	Two component regulator propeller
K6V30_RS04285	COG3292	Two component regulator propeller
K6V30_RS04285	COG0745	RESPONSE REGULATOR receiver
K6V30_RS04285	COG2205	protein histidine kinase activity
K6V30_RS04285	COG2205	protein histidine kinase activity
K6V30_RS04285	COG0745	RESPONSE REGULATOR receiver
K6V30_RS04295	COG0012	GTP binding
K6V30_RS04300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6V30_RS04305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6V30_RS04320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V30_RS04325	COG0662	Cupin 2, conserved barrel domain protein
K6V30_RS04325	COG2207	Transcriptional regulator
K6V30_RS04330	COG3250	beta-galactosidase activity
K6V30_RS04340	COG0697	spore germination
K6V30_RS04360	COG0495	leucyl-tRNA aminoacylation
K6V30_RS04365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6V30_RS04370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6V30_RS04375	COG1360	Flagellar Motor Protein
K6V30_RS04385	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V30_RS04390	COG3537	Alpha-1,2-mannosidase
K6V30_RS04410	COG2205	protein histidine kinase activity
K6V30_RS04410	COG2205	protein histidine kinase activity
K6V30_RS04410	COG3292	Two component regulator propeller
K6V30_RS04410	COG3292	Two component regulator propeller
K6V30_RS04410	COG0745	RESPONSE REGULATOR receiver
K6V30_RS04410	COG0745	RESPONSE REGULATOR receiver
K6V30_RS04430	COG1629	transport
K6V30_RS04435	COG0702	epimerase
K6V30_RS04445	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V30_RS04455	COG4948	Mandelate Racemase Muconate Lactonizing
K6V30_RS04460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6V30_RS04480	COG0731	radical SAM domain protein
K6V30_RS04480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V30_RS04505	COG0659	secondary active sulfate transmembrane transporter activity
K6V30_RS04510	COG1592	Rubrerythrin
K6V30_RS04565	COG0427	acetyl-CoA hydrolase
K6V30_RS04575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V30_RS04600	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS04615	COG3209	COG3209 Rhs family protein
K6V30_RS04635	COG2177	Part of the ABC transporter FtsEX involved in
K6V30_RS04645	COG1968	undecaprenyl-diphosphatase activity
K6V30_RS04650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6V30_RS04655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V30_RS04665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6V30_RS04670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6V30_RS04675	COG2184	nucleotidyltransferase activity
K6V30_RS04750	COG0594	ribonuclease P activity
K6V30_RS04755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K6V30_RS04765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6V30_RS04775	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K6V30_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
K6V30_RS04805	COG1629	transport
K6V30_RS04805	COG4206	TonB-dependent receptor
K6V30_RS04810	COG4771	TonB-dependent receptor
K6V30_RS04870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6V30_RS04890	COG1121	(ABC) transporter
K6V30_RS04900	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6V30_RS04900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6V30_RS04920	COG1506	peptidase
K6V30_RS04920	COG0823	Involved in the tonB-independent uptake of proteins
K6V30_RS04925	COG0116	Belongs to the methyltransferase superfamily
K6V30_RS04925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6V30_RS04930	COG1045	serine acetyltransferase
K6V30_RS04935	COG3275	phosphorelay sensor kinase activity
K6V30_RS04940	COG3279	Response regulator of the LytR AlgR family
K6V30_RS04950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V30_RS04950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V30_RS04965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6V30_RS04970	COG1694	Mazg nucleotide pyrophosphohydrolase
K6V30_RS04975	COG1490	D-aminoacyl-tRNA deacylase activity
K6V30_RS04980	COG0322	excinuclease ABC activity
K6V30_RS04985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V30_RS04990	COG0445	tRNA wobble uridine modification
K6V30_RS05005	COG4771	TonB-dependent receptor
K6V30_RS05045	COG1629	transport
K6V30_RS05045	COG4206	TonB-dependent receptor
K6V30_RS05065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6V30_RS05070	COG0700	Nucleoside recognition
K6V30_RS05075	COG2255	four-way junction helicase activity
K6V30_RS05095	COG3591	Belongs to the peptidase S1B family
K6V30_RS05105	COG3250	beta-galactosidase activity
K6V30_RS05115	COG0702	epimerase
K6V30_RS05120	COG1629	transport
K6V30_RS05145	COG0745	RESPONSE REGULATOR receiver
K6V30_RS05145	COG3292	Two component regulator propeller
K6V30_RS05145	COG2205	protein histidine kinase activity
K6V30_RS05155	COG0513	Belongs to the DEAD box helicase family
K6V30_RS05180	COG0612	Peptidase, M16
K6V30_RS05190	COG0681	Belongs to the peptidase S26 family
K6V30_RS05200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6V30_RS05210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V30_RS05220	COG5492	domain, Protein
K6V30_RS05240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6V30_RS05260	COG0702	epimerase
K6V30_RS05265	COG1629	transport
K6V30_RS05270	COG3119	arylsulfatase activity
K6V30_RS05275	COG2205	protein histidine kinase activity
K6V30_RS05275	COG3292	Two component regulator propeller
K6V30_RS05275	COG0745	RESPONSE REGULATOR receiver
K6V30_RS05275	COG2205	protein histidine kinase activity
K6V30_RS05275	COG3292	Two component regulator propeller
K6V30_RS05275	COG0745	RESPONSE REGULATOR receiver
K6V30_RS05285	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V30_RS05290	COG1538	Outer membrane efflux protein
K6V30_RS05300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS05305	COG3250	beta-galactosidase activity
K6V30_RS05330	COG0702	epimerase
K6V30_RS05335	COG4771	TonB-dependent receptor
K6V30_RS05355	COG0673	inositol 2-dehydrogenase activity
K6V30_RS05360	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V30_RS05365	COG3119	arylsulfatase activity
K6V30_RS05370	COG5492	domain, Protein
K6V30_RS05375	COG0215	cysteine-tRNA ligase activity
K6V30_RS05380	COG0561	phosphatase activity
K6V30_RS05405	COG0482	sulfurtransferase activity
K6V30_RS05415	COG0205	6-phosphofructokinase activity
K6V30_RS05420	COG0571	ribonuclease III activity
K6V30_RS05425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6V30_RS05430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6V30_RS05435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6V30_RS05440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6V30_RS05470	COG1216	Glycosyl transferase, family 2
K6V30_RS05470	COG1442	glycosyl transferase family 8
K6V30_RS05490	COG1215	transferase activity, transferring glycosyl groups
K6V30_RS05495	COG1216	Glycosyl transferase, family 2
K6V30_RS05510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V30_RS05515	COG0436	Aminotransferase
K6V30_RS05535	COG0463	Glycosyl transferase, family 2
K6V30_RS05570	COG1132	(ABC) transporter
K6V30_RS05595	COG3341	Caulimovirus viroplasmin
K6V30_RS05595	COG0328	RNA-DNA hybrid ribonuclease activity
K6V30_RS05605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6V30_RS05610	COG1166	arginine decarboxylase activity
K6V30_RS05615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6V30_RS05620	COG1595	DNA-templated transcription, initiation
K6V30_RS05645	COG0779	Required for maturation of 30S ribosomal subunits
K6V30_RS05650	COG0195	Participates in both transcription termination and antitermination
K6V30_RS05655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6V30_RS05665	COG0719	Fe-S assembly protein
K6V30_RS05670	COG0396	ATPase activity
K6V30_RS05675	COG0719	Fe-S assembly protein
K6V30_RS05680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6V30_RS05685	COG0393	Putative heavy-metal-binding
K6V30_RS05690	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K6V30_RS05695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6V30_RS05720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6V30_RS05735	COG0187	DNA topoisomerase II activity
K6V30_RS05740	COG0268	Binds directly to 16S ribosomal RNA
K6V30_RS05790	COG1381	Involved in DNA repair and RecF pathway recombination
K6V30_RS05840	COG1610	YqeY-like protein
K6V30_RS05845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6V30_RS05860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6V30_RS05870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6V30_RS05875	COG0772	Belongs to the SEDS family
K6V30_RS05880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6V30_RS05885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V30_RS05890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6V30_RS05905	COG0275	rRNA processing
K6V30_RS05910	COG2001	Belongs to the MraZ family
K6V30_RS05915	COG1595	DNA-templated transcription, initiation
K6V30_RS05930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6V30_RS05935	COG0756	dUTP diphosphatase activity
K6V30_RS05950	COG4942	peptidase
K6V30_RS05955	COG2205	protein histidine kinase activity
K6V30_RS05955	COG0745	RESPONSE REGULATOR receiver
K6V30_RS05955	COG3292	Two component regulator propeller
K6V30_RS05980	COG4771	TonB-dependent receptor
K6V30_RS06005	COG4771	TonB-dependent receptor
K6V30_RS06010	COG0702	epimerase
K6V30_RS06035	COG4771	TonB-dependent receptor
K6V30_RS06040	COG0702	epimerase
K6V30_RS06080	COG3250	beta-galactosidase activity
K6V30_RS06090	COG3940	Belongs to the glycosyl hydrolase 43 family
K6V30_RS06100	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V30_RS06120	COG3537	Alpha-1,2-mannosidase
K6V30_RS06135	COG3537	Alpha-1,2-mannosidase
K6V30_RS06230	COG1373	ATPase (AAA superfamily
K6V30_RS06235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6V30_RS06240	COG1022	Amp-dependent synthetase and ligase
K6V30_RS06245	COG0612	Peptidase, M16
K6V30_RS06260	COG2954	triphosphatase activity
K6V30_RS06330	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V30_RS06335	COG0561	phosphatase activity
K6V30_RS06340	COG4771	TonB-dependent receptor
K6V30_RS06380	COG2169	Transcriptional regulator
K6V30_RS06380	COG1917	Cupin 2, conserved barrel domain protein
K6V30_RS06425	COG0673	inositol 2-dehydrogenase activity
K6V30_RS06435	COG0673	inositol 2-dehydrogenase activity
K6V30_RS06445	COG0363	glucosamine-6-phosphate deaminase activity
K6V30_RS06450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6V30_RS06495	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS06510	COG0673	inositol 2-dehydrogenase activity
K6V30_RS06515	COG0673	inositol 2-dehydrogenase activity
K6V30_RS06525	COG0702	epimerase
K6V30_RS06530	COG4771	TonB-dependent receptor
K6V30_RS06540	COG2814	Major facilitator Superfamily
K6V30_RS06550	COG3458	cephalosporin-C deacetylase activity
K6V30_RS06555	COG2207	Transcriptional regulator
K6V30_RS06555	COG1609	Transcriptional regulator
K6V30_RS06565	COG0423	glycine-tRNA ligase activity
K6V30_RS06590	COG0738	Major facilitator superfamily
K6V30_RS06595	COG1063	alcohol dehydrogenase
K6V30_RS06610	COG2211	Major facilitator Superfamily
K6V30_RS06615	COG2247	cell wall binding repeat
K6V30_RS06615	COG2385	sporulation resulting in formation of a cellular spore
K6V30_RS06680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6V30_RS06685	COG0475	glutathione-regulated potassium exporter activity
K6V30_RS06685	COG0589	response to stress
K6V30_RS06690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6V30_RS06695	COG1136	(ABC) transporter
K6V30_RS06705	COG0733	neurotransmitter:sodium symporter activity
K6V30_RS06715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6V30_RS06720	COG0784	Response regulator, receiver
K6V30_RS06720	COG5002	protein histidine kinase activity
K6V30_RS06720	COG2205	protein histidine kinase activity
K6V30_RS06725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6V30_RS06730	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K6V30_RS06735	COG0312	modulator of DNA gyrase
K6V30_RS06740	COG0312	modulator of DNA gyrase
K6V30_RS06760	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V30_RS06800	COG3292	Two component regulator propeller
K6V30_RS06800	COG0745	RESPONSE REGULATOR receiver
K6V30_RS06800	COG2205	protein histidine kinase activity
K6V30_RS06810	COG1629	transport
K6V30_RS06855	COG1346	cytolysis
K6V30_RS06865	COG0280	phosphate acetyltransferase
K6V30_RS06870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6V30_RS06875	COG0463	Glycosyl transferase, family 2
K6V30_RS06875	COG1216	Glycosyl transferase, family 2
K6V30_RS06880	COG2003	Belongs to the UPF0758 family
K6V30_RS06890	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V30_RS06895	COG0366	Alpha amylase catalytic
K6V30_RS06910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V30_RS06915	COG4206	TonB-dependent receptor
K6V30_RS06915	COG1629	transport
K6V30_RS06920	COG1082	Xylose isomerase domain protein TIM barrel
K6V30_RS06925	COG0366	Alpha amylase catalytic
K6V30_RS06935	COG1785	Belongs to the alkaline phosphatase family
K6V30_RS06940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6V30_RS06945	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K6V30_RS06950	COG0515	serine threonine protein kinase
K6V30_RS06950	COG2815	serine threonine protein kinase
K6V30_RS06955	COG0564	pseudouridine synthase activity
K6V30_RS06960	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6V30_RS06980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K6V30_RS06985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6V30_RS06990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6V30_RS06995	COG0436	Aminotransferase
K6V30_RS07005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6V30_RS07025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6V30_RS07030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6V30_RS07040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V30_RS07040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V30_RS07045	COG2890	protein-(glutamine-N5) methyltransferase activity
K6V30_RS07055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6V30_RS07065	COG0165	Argininosuccinate lyase
K6V30_RS07190	COG0305	Participates in initiation and elongation during chromosome replication
K6V30_RS07225	COG2315	Protein conserved in bacteria
K6V30_RS07285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6V30_RS07290	COG1917	Cupin 2, conserved barrel domain protein
K6V30_RS07290	COG1396	sequence-specific DNA binding
K6V30_RS07295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6V30_RS07300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6V30_RS07305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6V30_RS07310	COG0137	argininosuccinate synthase activity
K6V30_RS07320	COG1438	arginine binding
K6V30_RS07325	COG1070	Carbohydrate kinase
K6V30_RS07330	COG4806	L-rhamnose isomerase
K6V30_RS07340	COG0235	Class ii aldolase
K6V30_RS07345	COG1454	alcohol dehydrogenase
K6V30_RS07375	COG0564	pseudouridine synthase activity
K6V30_RS07380	COG3537	Alpha-1,2-mannosidase
K6V30_RS07420	COG3537	Alpha-1,2-mannosidase
K6V30_RS07425	COG0745	RESPONSE REGULATOR receiver
K6V30_RS07425	COG2205	protein histidine kinase activity
K6V30_RS07425	COG3292	Two component regulator propeller
K6V30_RS07435	COG4206	TonB-dependent receptor
K6V30_RS07435	COG1629	transport
K6V30_RS07440	COG0702	epimerase
K6V30_RS07465	COG3119	arylsulfatase activity
K6V30_RS07480	COG3119	arylsulfatase activity
K6V30_RS07485	COG3292	Two component regulator propeller
K6V30_RS07485	COG2205	protein histidine kinase activity
K6V30_RS07485	COG0745	RESPONSE REGULATOR receiver
K6V30_RS07495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6V30_RS07500	COG0612	Peptidase, M16
K6V30_RS07505	COG0534	Mate efflux family protein
K6V30_RS07510	COG2205	protein histidine kinase activity
K6V30_RS07510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V30_RS07530	COG0488	(ABC) transporter
K6V30_RS07535	COG3590	peptidase
K6V30_RS07540	COG0138	bifunctional purine biosynthesis protein purh
K6V30_RS07565	COG0772	Belongs to the SEDS family
K6V30_RS07575	COG1774	PSP1 C-terminal conserved region
K6V30_RS07580	COG0470	DNA polymerase III
K6V30_RS07585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6V30_RS07595	COG2193	ferroxidase activity
K6V30_RS07635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V30_RS07640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6V30_RS07645	COG1160	GTP binding
K6V30_RS07655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6V30_RS07660	COG1127	ABC transporter
K6V30_RS07665	COG0724	RNA recognition motif
K6V30_RS07670	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6V30_RS07675	COG0740	serine-type endopeptidase activity
K6V30_RS07680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6V30_RS07685	COG0514	ATP-dependent DNA helicase (RecQ)
K6V30_RS07690	COG0516	GMP reductase activity
K6V30_RS07690	COG0517	IMP dehydrogenase activity
K6V30_RS07695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6V30_RS07705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6V30_RS07720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6V30_RS07725	COG2885	chlorophyll binding
K6V30_RS07740	COG4771	TonB-dependent receptor
K6V30_RS07760	COG3537	Alpha-1,2-mannosidase
K6V30_RS07795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V30_RS07805	COG3022	response to hydroperoxide
K6V30_RS07810	COG0110	maltose O-acetyltransferase activity
K6V30_RS07835	COG1187	pseudouridine synthase activity
K6V30_RS07840	COG0017	Asparaginyl-tRNA synthetase
K6V30_RS07850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6V30_RS07855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6V30_RS07860	COG0052	Belongs to the universal ribosomal protein uS2 family
K6V30_RS07865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6V30_RS07880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K6V30_RS07885	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6V30_RS07890	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6V30_RS07905	COG0482	sulfurtransferase activity
K6V30_RS07915	COG1570	exodeoxyribonuclease VII activity
K6V30_RS07925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6V30_RS07935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6V30_RS07940	COG0489	protein tyrosine kinase activity
K6V30_RS07945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V30_RS07975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS07995	COG0714	Associated with various cellular activities
K6V30_RS08000	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6V30_RS08005	COG3552	Protein containing von Willebrand factor type A (VWA) domain
K6V30_RS08015	COG0039	L-malate dehydrogenase activity
K6V30_RS08050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6V30_RS08055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6V30_RS08060	COG0811	peptide transport
K6V30_RS08065	COG0848	biopolymer transport protein
K6V30_RS08080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6V30_RS08085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6V30_RS08090	COG0105	UTP biosynthetic process
K6V30_RS08095	COG0739	heme binding
K6V30_RS08110	COG0149	triose-phosphate isomerase activity
K6V30_RS08120	COG0302	gtp cyclohydrolase
K6V30_RS08125	COG0358	DNA primase activity
K6V30_RS08135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K6V30_RS08140	COG0436	Aminotransferase
K6V30_RS08155	COG0514	ATP-dependent DNA helicase (RecQ)
K6V30_RS08160	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K6V30_RS08160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6V30_RS08175	COG0009	L-threonylcarbamoyladenylate synthase
K6V30_RS08185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6V30_RS08190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6V30_RS08195	COG0658	competence protein
K6V30_RS08195	COG2333	competence protein COMEC
K6V30_RS08200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6V30_RS08210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V30_RS08220	COG4771	TonB-dependent receptor
K6V30_RS08225	COG0561	phosphatase activity
K6V30_RS08245	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS08260	COG0202	RNA polymerase activity
K6V30_RS08285	COG1917	Cupin 2, conserved barrel domain protein
K6V30_RS08285	COG4977	sequence-specific DNA binding
K6V30_RS08290	COG4771	TonB-dependent receptor
K6V30_RS08300	COG3537	Alpha-1,2-mannosidase
K6V30_RS08315	COG3537	Alpha-1,2-mannosidase
K6V30_RS08330	COG3940	Belongs to the glycosyl hydrolase 43 family
K6V30_RS08355	COG1629	transport
K6V30_RS08385	COG3279	Response regulator of the LytR AlgR family
K6V30_RS08390	COG3275	phosphorelay sensor kinase activity
K6V30_RS08415	COG0386	Belongs to the glutathione peroxidase family
K6V30_RS08425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V30_RS08440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6V30_RS08455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6V30_RS08460	COG0742	ribosomal rna small subunit methyltransferase
K6V30_RS08475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V30_RS08480	COG4771	TonB-dependent receptor
K6V30_RS08515	COG3537	Alpha-1,2-mannosidase
K6V30_RS08520	COG3537	Alpha-1,2-mannosidase
K6V30_RS08545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6V30_RS08550	COG0739	heme binding
K6V30_RS08560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V30_RS08565	COG0741	lytic transglycosylase activity
K6V30_RS08565	COG1388	LysM domain
K6V30_RS08575	COG1475	DNA binding
K6V30_RS08580	COG1192	Involved in chromosome partitioning
K6V30_RS08585	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6V30_RS08590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V30_RS08605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6V30_RS08610	COG0799	negative regulation of ribosome biogenesis
K6V30_RS08620	COG0702	epimerase
K6V30_RS08625	COG4206	TonB-dependent receptor
K6V30_RS08625	COG1629	transport
K6V30_RS08635	COG1196	nuclear chromosome segregation
K6V30_RS08640	COG2239	Acts as a magnesium transporter
K6V30_RS08645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6V30_RS08655	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V30_RS08685	COG1119	ATPase activity
K6V30_RS08695	COG0668	transmembrane transport
K6V30_RS08700	COG2207	Transcriptional regulator
K6V30_RS08700	COG0662	Cupin 2, conserved barrel domain protein
K6V30_RS08715	COG0784	Response regulator, receiver
K6V30_RS08715	COG2205	protein histidine kinase activity
K6V30_RS08715	COG5002	protein histidine kinase activity
K6V30_RS08725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V30_RS08730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6V30_RS08735	COG0713	ATP synthesis coupled electron transport
K6V30_RS08750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K6V30_RS08755	COG0649	NAD binding
K6V30_RS08755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V30_RS08760	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V30_RS08765	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V30_RS08800	COG3250	beta-galactosidase activity
K6V30_RS08810	COG3250	beta-galactosidase activity
K6V30_RS08820	COG0657	acetylesterase activity
K6V30_RS08820	COG2755	lipolytic protein G-D-S-L family
K6V30_RS08835	COG1629	transport
K6V30_RS08840	COG0702	epimerase
K6V30_RS08855	COG0702	epimerase
K6V30_RS08870	COG4771	TonB-dependent receptor
K6V30_RS08875	COG0702	epimerase
K6V30_RS08880	COG1629	transport
K6V30_RS08880	COG4206	TonB-dependent receptor
K6V30_RS08895	COG3537	Alpha-1,2-mannosidase
K6V30_RS08915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V30_RS08925	COG0569	domain protein
K6V30_RS08930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6V30_RS08940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6V30_RS08945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6V30_RS08950	COG0805	protein transport
K6V30_RS08960	COG2271	Major facilitator Superfamily
K6V30_RS08965	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K6V30_RS08970	COG3775	system Galactitol-specific IIC component
K6V30_RS08975	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V30_RS08985	COG2755	lipolytic protein G-D-S-L family
K6V30_RS08990	COG3292	Two component regulator propeller
K6V30_RS08990	COG2205	protein histidine kinase activity
K6V30_RS08990	COG0745	RESPONSE REGULATOR receiver
K6V30_RS09000	COG0702	epimerase
K6V30_RS09005	COG4771	TonB-dependent receptor
K6V30_RS09025	COG3279	Response regulator of the LytR AlgR family
K6V30_RS09045	COG1629	transport
K6V30_RS09045	COG4206	TonB-dependent receptor
K6V30_RS09060	COG2205	protein histidine kinase activity
K6V30_RS09060	COG3292	Two component regulator propeller
K6V30_RS09060	COG0745	RESPONSE REGULATOR receiver
K6V30_RS09065	COG1242	4 iron, 4 sulfur cluster binding
K6V30_RS09075	COG0363	glucosamine-6-phosphate deaminase activity
K6V30_RS09080	COG0009	L-threonylcarbamoyladenylate synthase
K6V30_RS09090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V30_RS09095	COG0561	phosphatase activity
K6V30_RS09105	COG0745	RESPONSE REGULATOR receiver
K6V30_RS09115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6V30_RS09160	COG0778	Nitroreductase
K6V30_RS09250	COG2755	lipolytic protein G-D-S-L family
K6V30_RS09285	COG3250	beta-galactosidase activity
K6V30_RS09295	COG3250	beta-galactosidase activity
K6V30_RS09300	COG3345	alpha-galactosidase
K6V30_RS09365	COG4771	TonB-dependent receptor
K6V30_RS09385	COG4771	TonB-dependent receptor
K6V30_RS09405	COG4771	TonB-dependent receptor
K6V30_RS09410	COG0702	epimerase
K6V30_RS09425	COG4771	TonB-dependent receptor
K6V30_RS09450	COG2755	lipolytic protein G-D-S-L family
K6V30_RS09460	COG3401	FG-GAP repeat protein
K6V30_RS09470	COG3254	rhamnose metabolic process
K6V30_RS09475	COG2205	protein histidine kinase activity
K6V30_RS09475	COG3292	Two component regulator propeller
K6V30_RS09475	COG2205	protein histidine kinase activity
K6V30_RS09475	COG0745	RESPONSE REGULATOR receiver
K6V30_RS09475	COG3292	Two component regulator propeller
K6V30_RS09475	COG0745	RESPONSE REGULATOR receiver
K6V30_RS09480	COG2755	lipolytic protein G-D-S-L family
K6V30_RS09485	COG2755	lipolytic protein G-D-S-L family
K6V30_RS09490	COG3250	beta-galactosidase activity
K6V30_RS09495	COG3292	Two component regulator propeller
K6V30_RS09495	COG2205	protein histidine kinase activity
K6V30_RS09495	COG0745	RESPONSE REGULATOR receiver
K6V30_RS09505	COG0546	phosphoglycolate phosphatase activity
K6V30_RS09545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6V30_RS09605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6V30_RS09620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6V30_RS09620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6V30_RS09625	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V30_RS09630	COG1078	dGTPase activity
K6V30_RS09635	COG0284	orotidine-5'-phosphate decarboxylase activity
K6V30_RS09640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6V30_RS09650	COG1704	LemA family
K6V30_RS09665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6V30_RS09670	COG2226	methyltransferase
K6V30_RS09675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6V30_RS09680	COG1702	phosphate starvation-inducible protein PhoH
K6V30_RS09695	COG2268	Band 7 protein
K6V30_RS09770	COG2205	protein histidine kinase activity
K6V30_RS09770	COG0745	RESPONSE REGULATOR receiver
K6V30_RS09770	COG3292	Two component regulator propeller
K6V30_RS09775	COG0101	tRNA pseudouridine synthase activity
K6V30_RS09795	COG3250	beta-galactosidase activity
K6V30_RS09800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6V30_RS09805	COG0673	inositol 2-dehydrogenase activity
K6V30_RS09825	COG1629	transport
K6V30_RS09825	COG4206	TonB-dependent receptor
K6V30_RS09845	COG5434	Belongs to the glycosyl hydrolase 28 family
K6V30_RS09850	COG0673	inositol 2-dehydrogenase activity
K6V30_RS09865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6V30_RS09875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K6V30_RS09890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6V30_RS09895	COG0793	Belongs to the peptidase S41A family
K6V30_RS09900	COG2131	deaminase
K6V30_RS09910	COG0339	signal peptide processing
K6V30_RS09920	COG1970	mechanosensitive ion channel activity
K6V30_RS09925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6V30_RS09925	COG0519	Catalyzes the synthesis of GMP from XMP
K6V30_RS09935	COG4771	TonB-dependent receptor
K6V30_RS09990	COG0463	Glycosyl transferase, family 2
K6V30_RS10055	COG4771	TonB-dependent receptor
K6V30_RS10085	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS10100	COG0297	glycogen (starch) synthase activity
K6V30_RS10105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6V30_RS10110	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K6V30_RS10120	COG0543	2 iron, 2 sulfur cluster binding
K6V30_RS10130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6V30_RS10135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6V30_RS10140	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6V30_RS10145	COG0546	phosphoglycolate phosphatase activity
K6V30_RS10155	COG0791	NLP P60 protein
K6V30_RS10170	COG0612	Peptidase, M16
K6V30_RS10175	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6V30_RS10180	COG1597	lipid kinase activity
K6V30_RS10185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6V30_RS10200	COG1136	(ABC) transporter
K6V30_RS10220	COG2211	Major facilitator Superfamily
K6V30_RS10225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6V30_RS10240	COG1674	ftsk spoiiie
K6V30_RS10250	COG0492	ferredoxin-NADP+ reductase activity
K6V30_RS10255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS10285	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K6V30_RS10285	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K6V30_RS10295	COG1234	tRNA 3'-trailer cleavage
K6V30_RS10315	COG3956	TIGRFAM MazG family protein
K6V30_RS10330	COG0525	valine-tRNA ligase activity
K6V30_RS10335	COG2205	protein histidine kinase activity
K6V30_RS10335	COG0784	Response regulator, receiver
K6V30_RS10350	COG1629	transport
K6V30_RS10350	COG4206	TonB-dependent receptor
K6V30_RS10375	COG0653	protein targeting
K6V30_RS10380	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
K6V30_RS10390	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K6V30_RS10410	COG1253	flavin adenine dinucleotide binding
K6V30_RS10420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K6V30_RS10430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6V30_RS10435	COG2204	response regulator
K6V30_RS10475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6V30_RS10475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6V30_RS10490	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6V30_RS10495	COG0563	adenylate kinase activity
K6V30_RS10500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V30_RS10505	COG1496	oxidoreductase activity
K6V30_RS10520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS10525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS10535	COG0477	Major facilitator Superfamily
K6V30_RS10535	COG2814	Major facilitator Superfamily
K6V30_RS10540	COG0457	Tetratricopeptide repeat
K6V30_RS10545	COG2706	6-phosphogluconolactonase activity
K6V30_RS10550	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V30_RS10570	COG1629	transport
K6V30_RS10570	COG4206	TonB-dependent receptor
K6V30_RS10635	COG3142	Participates in the control of copper homeostasis
K6V30_RS10640	COG1418	mRNA catabolic process
K6V30_RS10670	COG1070	Carbohydrate kinase
K6V30_RS10675	COG1063	alcohol dehydrogenase
K6V30_RS10680	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6V30_RS10705	COG1333	cytochrome c biogenesis protein
K6V30_RS10705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V30_RS10725	COG0673	inositol 2-dehydrogenase activity
K6V30_RS10735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V30_RS10740	COG2832	Protein of unknown function (DUF454)
K6V30_RS10750	COG0602	queuosine metabolic process
K6V30_RS10755	COG0247	lactate metabolic process
K6V30_RS10760	COG1139	Iron-sulfur cluster binding protein
K6V30_RS10770	COG0351	phosphomethylpyrimidine kinase
K6V30_RS10785	COG1629	transport
K6V30_RS10795	COG2304	oxidoreductase activity
K6V30_RS10805	COG1393	Belongs to the ArsC family
K6V30_RS10815	COG4771	TonB-dependent receptor
K6V30_RS10830	COG2233	PERMEase
K6V30_RS10835	COG1509	lysine 2,3-aminomutase activity
K6V30_RS10845	COG1115	amino acid carrier protein
K6V30_RS10860	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS10870	COG0776	regulation of translation
K6V30_RS10915	COG1285	pathogenesis
K6V30_RS10925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6V30_RS10930	COG0741	lytic transglycosylase activity
K6V30_RS10930	COG1388	LysM domain
K6V30_RS10985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V30_RS11000	COG0534	Mate efflux family protein
K6V30_RS11005	COG0564	pseudouridine synthase activity
K6V30_RS11030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6V30_RS11040	COG0346	lactoylglutathione lyase activity
K6V30_RS11090	COG1063	alcohol dehydrogenase
K6V30_RS11115	COG1061	Type III restriction enzyme res subunit
K6V30_RS11180	COG2433	Pfam Transposase IS66
K6V30_RS11215	COG4974	Belongs to the 'phage' integrase family
K6V30_RS11235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6V30_RS11240	COG2205	protein histidine kinase activity
K6V30_RS11240	COG0784	Response regulator, receiver
K6V30_RS11245	COG2910	NAD(P)H-binding
K6V30_RS11260	COG4864	UPF0365 protein
K6V30_RS11275	COG0037	tRNA processing
K6V30_RS11300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6V30_RS11340	COG1362	aminopeptidase activity
K6V30_RS11345	COG0641	radical SAM
K6V30_RS11355	COG1477	protein flavinylation
K6V30_RS11360	COG1971	Probably functions as a manganese efflux pump
K6V30_RS11375	COG0463	Glycosyl transferase, family 2
K6V30_RS11405	COG0148	phosphopyruvate hydratase activity
K6V30_RS11415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6V30_RS11445	COG1082	Xylose isomerase domain protein TIM barrel
K6V30_RS11450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6V30_RS11455	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V30_RS11460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6V30_RS11480	COG4651	solute:proton antiporter activity
K6V30_RS11480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6V30_RS11490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6V30_RS11495	COG0193	aminoacyl-tRNA hydrolase activity
K6V30_RS11500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6V30_RS11510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6V30_RS11515	COG1862	Preprotein translocase
K6V30_RS11525	COG0237	dephospho-CoA kinase activity
K6V30_RS11540	COG0542	response to heat
K6V30_RS11550	COG0583	DNA-binding transcription factor activity
K6V30_RS11555	COG3304	Inner membrane component domain
K6V30_RS11560	COG2855	membrane
K6V30_RS11565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6V30_RS11570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6V30_RS11595	COG0443	Heat shock 70 kDa protein
K6V30_RS11605	COG0306	phosphate transporter
K6V30_RS11615	COG0586	Pfam SNARE associated Golgi protein
K6V30_RS11675	COG0038	chloride channel
K6V30_RS11680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6V30_RS11700	COG3119	arylsulfatase activity
K6V30_RS11710	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V30_RS11725	COG0702	epimerase
K6V30_RS11730	COG4771	TonB-dependent receptor
K6V30_RS11740	COG5434	Belongs to the glycosyl hydrolase 28 family
K6V30_RS11750	COG0745	RESPONSE REGULATOR receiver
K6V30_RS11750	COG2205	protein histidine kinase activity
K6V30_RS11750	COG3292	Two component regulator propeller
K6V30_RS11755	COG2172	sigma factor antagonist activity
K6V30_RS11770	COG1366	Belongs to the anti-sigma-factor antagonist family
K6V30_RS11780	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K6V30_RS11785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V30_RS11800	COG3250	beta-galactosidase activity
K6V30_RS11815	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V30_RS11820	COG4206	TonB-dependent receptor
K6V30_RS11820	COG1629	transport
K6V30_RS11830	COG3292	Two component regulator propeller
K6V30_RS11830	COG0745	RESPONSE REGULATOR receiver
K6V30_RS11830	COG2205	protein histidine kinase activity
K6V30_RS11855	COG1760	l-serine dehydratase
K6V30_RS11860	COG0598	Magnesium transport protein CorA
K6V30_RS11865	COG1193	negative regulation of DNA recombination
K6V30_RS11875	COG4974	Belongs to the 'phage' integrase family
K6V30_RS11915	COG1196	nuclear chromosome segregation
K6V30_RS12030	COG0501	Belongs to the peptidase M48B family
K6V30_RS12045	COG1475	DNA binding
K6V30_RS12100	COG1216	Glycosyl transferase, family 2
K6V30_RS12105	COG2194	sulfuric ester hydrolase activity
K6V30_RS12115	COG1442	glycosyl transferase family 8
K6V30_RS12115	COG1216	Glycosyl transferase, family 2
K6V30_RS12125	COG1216	Glycosyl transferase, family 2
K6V30_RS12140	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS12145	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS12150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V30_RS12205	COG1132	(ABC) transporter
K6V30_RS12210	COG2198	Histidine kinase
K6V30_RS12210	COG2205	protein histidine kinase activity
K6V30_RS12210	COG0784	Response regulator, receiver
K6V30_RS12215	COG2204	response regulator
K6V30_RS12315	COG0517	IMP dehydrogenase activity
K6V30_RS12330	COG1629	transport
K6V30_RS12330	COG4206	TonB-dependent receptor
K6V30_RS12390	COG4584	PFAM Integrase catalytic
K6V30_RS12395	COG1484	DNA-dependent DNA replication
K6V30_RS12405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS12420	COG3250	beta-galactosidase activity
K6V30_RS12435	COG1629	transport
K6V30_RS12445	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K6V30_RS12450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS12460	COG1538	Outer membrane efflux protein
K6V30_RS12470	COG0456	acetyltransferase
K6V30_RS12485	COG0561	phosphatase activity
K6V30_RS12490	COG1169	isochorismate synthase
K6V30_RS12495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6V30_RS12500	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6V30_RS12505	COG4948	Mandelate Racemase Muconate Lactonizing
K6V30_RS12510	COG0318	PFAM AMP-dependent synthetase and ligase
K6V30_RS12525	COG4206	TonB-dependent receptor
K6V30_RS12525	COG1629	transport
K6V30_RS12565	COG0783	Belongs to the Dps family
K6V30_RS12580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6V30_RS12610	COG4771	TonB-dependent receptor
K6V30_RS12615	COG0702	epimerase
K6V30_RS12675	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS12680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6V30_RS12685	COG1882	Formate acetyltransferase
K6V30_RS12695	COG4974	Belongs to the 'phage' integrase family
K6V30_RS12845	COG0551	DNA topoisomerase type I activity
K6V30_RS12845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6V30_RS12905	COG3831	ATPase activity
K6V30_RS12905	COG4884	unkown
K6V30_RS12920	COG4974	Belongs to the 'phage' integrase family
K6V30_RS12925	COG1309	transcriptional regulator
K6V30_RS12930	COG4974	Belongs to the 'phage' integrase family
K6V30_RS12955	COG5290	Psort location Cytoplasmic, score
K6V30_RS12965	COG3328	transposase activity
K6V30_RS13150	COG0697	spore germination
K6V30_RS13155	COG1917	Cupin 2, conserved barrel domain protein
K6V30_RS13155	COG4977	sequence-specific DNA binding
K6V30_RS13160	COG1335	isochorismatase
K6V30_RS13165	COG2353	YceI-like domain
K6V30_RS13170	COG1741	Belongs to the pirin family
K6V30_RS13180	COG4206	TonB-dependent receptor
K6V30_RS13195	COG0501	Belongs to the peptidase M48B family
K6V30_RS13210	COG1475	DNA binding
K6V30_RS13235	COG1120	ATPase activity
K6V30_RS13240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6V30_RS13285	COG2217	Heavy metal translocating P-type atpase
K6V30_RS13305	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6V30_RS13305	COG1918	ferrous iron import across plasma membrane
K6V30_RS13310	COG2205	protein histidine kinase activity
K6V30_RS13310	COG0784	Response regulator, receiver
K6V30_RS13310	COG2198	Histidine kinase
K6V30_RS13315	COG2204	response regulator
K6V30_RS13365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V30_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
K6V30_RS13420	COG1082	Xylose isomerase domain protein TIM barrel
K6V30_RS13425	COG0656	L-ascorbic acid biosynthetic process
K6V30_RS13435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6V30_RS13455	COG1595	DNA-templated transcription, initiation
K6V30_RS13460	COG1629	transport
K6V30_RS13480	COG1373	ATPase (AAA superfamily
K6V30_RS13490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V30_RS13500	COG1253	flavin adenine dinucleotide binding
K6V30_RS13505	COG0501	Belongs to the peptidase M48B family
K6V30_RS13530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V30_RS13535	COG0482	sulfurtransferase activity
K6V30_RS13540	COG2197	response regulator
K6V30_RS13550	COG1757	Na H antiporter
K6V30_RS13565	COG2814	Major facilitator Superfamily
K6V30_RS13570	COG4953	penicillin-binding protein 1C
K6V30_RS13575	COG2373	Large extracellular alpha-helical protein
K6V30_RS13580	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V30_RS13665	COG2003	Belongs to the UPF0758 family
K6V30_RS13760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6V30_RS13875	COG2314	TM2 domain
K6V30_RS13945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6V30_RS13950	COG0646	methionine synthase
K6V30_RS13950	COG1410	methionine synthase
K6V30_RS13955	COG0778	Nitroreductase
K6V30_RS13960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6V30_RS13970	COG0572	uridine kinase
K6V30_RS13980	COG4232	protein-disulfide reductase activity
K6V30_RS13985	COG1741	Belongs to the pirin family
K6V30_RS14005	COG0702	epimerase
K6V30_RS14030	COG2271	Major facilitator Superfamily
K6V30_RS14050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6V30_RS14055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6V30_RS14060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6V30_RS14065	COG0131	Imidazoleglycerol-phosphate dehydratase
K6V30_RS14075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V30_RS14075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6V30_RS14080	COG4771	TonB-dependent receptor
K6V30_RS14110	COG1404	Belongs to the peptidase S8 family
K6V30_RS14130	COG1773	rubredoxin
K6V30_RS14130	COG1592	Rubrerythrin
K6V30_RS14145	COG3118	belongs to the thioredoxin family
K6V30_RS14160	COG3591	Belongs to the peptidase S1B family
K6V30_RS14165	COG3591	Belongs to the peptidase S1B family
K6V30_RS14170	COG0641	radical SAM
K6V30_RS14200	COG0420	3'-5' exonuclease activity
K6V30_RS14210	COG1408	metallophosphoesterase
K6V30_RS14225	COG0646	methionine synthase
K6V30_RS14225	COG1410	methionine synthase
K6V30_RS14235	COG0463	Glycosyl transferase, family 2
K6V30_RS14240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6V30_RS14245	COG1032	radical SAM domain protein
K6V30_RS14270	COG0363	glucosamine-6-phosphate deaminase activity
K6V30_RS14275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V30_RS14305	COG1629	transport
K6V30_RS14310	COG0702	epimerase
K6V30_RS14325	COG4771	TonB-dependent receptor
K6V30_RS14380	COG0811	peptide transport
K6V30_RS14385	COG0848	biopolymer transport protein
K6V30_RS14440	COG1131	(ABC) transporter
K6V30_RS14475	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6V30_RS14515	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6V30_RS14520	COG0022	dehydrogenase e1 component
K6V30_RS14530	COG2264	protein methyltransferase activity
K6V30_RS14550	COG5002	protein histidine kinase activity
K6V30_RS14565	COG1629	transport
K6V30_RS14565	COG4206	TonB-dependent receptor
K6V30_RS14580	COG0590	tRNA wobble adenosine to inosine editing
K6V30_RS14585	COG0673	inositol 2-dehydrogenase activity
K6V30_RS14610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6V30_RS14655	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6V30_RS14670	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V30_RS14675	COG5012	cobalamin binding
K6V30_RS14695	COG0698	ribose 5-phosphate isomerase
K6V30_RS14700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6V30_RS14715	COG1070	Carbohydrate kinase
K6V30_RS14720	COG2160	L-arabinose isomerase activity
K6V30_RS14755	COG0702	epimerase
K6V30_RS14760	COG1629	transport
K6V30_RS14760	COG4206	TonB-dependent receptor
K6V30_RS14765	COG0702	epimerase
K6V30_RS14770	COG4206	TonB-dependent receptor
K6V30_RS14770	COG1629	transport
K6V30_RS14780	COG0745	RESPONSE REGULATOR receiver
K6V30_RS14780	COG2205	protein histidine kinase activity
K6V30_RS14780	COG3292	Two component regulator propeller
K6V30_RS14785	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V30_RS14795	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V30_RS14800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6V30_RS14815	COG1482	cell wall glycoprotein biosynthetic process
K6V30_RS14820	COG4974	Belongs to the 'phage' integrase family
K6V30_RS14850	COG1086	Polysaccharide biosynthesis protein
K6V30_RS14925	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS14950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V30_RS14995	COG4656	Part of a membrane complex involved in electron transport
K6V30_RS15000	COG4658	electron transport chain
K6V30_RS15005	COG4659	FMN binding
K6V30_RS15010	COG4660	Part of a membrane complex involved in electron transport
K6V30_RS15015	COG4657	Part of a membrane complex involved in electron transport
K6V30_RS15020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6V30_RS15025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6V30_RS15030	COG0305	Participates in initiation and elongation during chromosome replication
K6V30_RS15035	COG0072	phenylalanine-tRNA ligase activity
K6V30_RS15035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6V30_RS15040	COG0217	transcriptional regulatory protein
K6V30_RS15055	COG0708	Exodeoxyribonuclease III
K6V30_RS15075	COG0481	GTPase activity
K6V30_RS15085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6V30_RS15115	COG0024	Methionine aminopeptidase
K6V30_RS15150	COG1518	maintenance of DNA repeat elements
K6V30_RS15155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K6V30_RS15165	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6V30_RS15175	COG0564	pseudouridine synthase activity
K6V30_RS15180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6V30_RS15185	COG0574	Belongs to the PEP-utilizing enzyme family
K6V30_RS15185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6V30_RS15200	COG0352	thiamine-phosphate diphosphorylase activity
K6V30_RS15205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6V30_RS15210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6V30_RS15215	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6V30_RS15220	COG2022	thiamine diphosphate biosynthetic process
K6V30_RS15225	COG0352	thiamine-phosphate diphosphorylase activity
K6V30_RS15235	COG4999	Histidine kinase
K6V30_RS15235	COG3850	Histidine kinase
K6V30_RS15235	COG3437	response regulator, receiver
K6V30_RS15235	COG2205	protein histidine kinase activity
K6V30_RS15260	COG1373	ATPase (AAA superfamily
K6V30_RS15335	COG0681	Belongs to the peptidase S26 family
K6V30_RS15420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6V30_RS15425	COG3118	belongs to the thioredoxin family
K6V30_RS15445	COG5002	protein histidine kinase activity
K6V30_RS15450	COG0745	RESPONSE REGULATOR receiver
K6V30_RS15455	COG0318	PFAM AMP-dependent synthetase and ligase
K6V30_RS15460	COG3263	regulation of cellular component size
K6V30_RS15465	COG2233	PERMEase
K6V30_RS15470	COG1151	hydroxylamine reductase activity
K6V30_RS15500	COG1136	(ABC) transporter
K6V30_RS15510	COG0534	Mate efflux family protein
K6V30_RS15520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6V30_RS15530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V30_RS15550	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6V30_RS15565	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS15590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6V30_RS15595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6V30_RS15605	COG0356	it plays a direct role in the translocation of protons across the membrane
K6V30_RS15610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V30_RS15615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6V30_RS15620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V30_RS15625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6V30_RS15630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6V30_RS15640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V30_RS15645	COG2431	L-lysine efflux transmembrane transporter activity
K6V30_RS15665	COG2207	Transcriptional regulator
K6V30_RS15705	COG2985	domain, Protein
K6V30_RS15710	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6V30_RS15720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6V30_RS15735	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6V30_RS15740	COG0540	Belongs to the ATCase OTCase family
K6V30_RS15755	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K6V30_RS15770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6V30_RS15775	COG2205	protein histidine kinase activity
K6V30_RS15815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6V30_RS15830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6V30_RS15840	COG0300	oxidoreductase activity
K6V30_RS15850	COG1011	Hydrolase
K6V30_RS15915	COG2205	protein histidine kinase activity
K6V30_RS15915	COG3292	Two component regulator propeller
K6V30_RS15915	COG0745	RESPONSE REGULATOR receiver
K6V30_RS15915	COG3292	Two component regulator propeller
K6V30_RS15915	COG2205	protein histidine kinase activity
K6V30_RS15915	COG0745	RESPONSE REGULATOR receiver
K6V30_RS15930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS15970	COG0515	serine threonine protein kinase
K6V30_RS15970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6V30_RS15980	COG0442	prolyl-tRNA aminoacylation
K6V30_RS15985	COG0745	RESPONSE REGULATOR receiver
K6V30_RS15990	COG2205	protein histidine kinase activity
K6V30_RS16025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6V30_RS16035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6V30_RS16040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6V30_RS16050	COG0552	protein localization to endoplasmic reticulum
K6V30_RS16055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V30_RS16065	COG0776	regulation of translation
K6V30_RS16070	COG0714	Associated with various cellular activities
K6V30_RS16085	COG2304	oxidoreductase activity
K6V30_RS16125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6V30_RS16135	COG0326	Molecular chaperone. Has ATPase activity
K6V30_RS16160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6V30_RS16165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6V30_RS16170	COG0336	Belongs to the RNA methyltransferase TrmD family
K6V30_RS16175	COG0167	dihydroorotate dehydrogenase activity
K6V30_RS16180	COG0543	2 iron, 2 sulfur cluster binding
K6V30_RS16195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V30_RS16225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6V30_RS16245	COG1132	(ABC) transporter
K6V30_RS16275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6V30_RS16280	COG1597	lipid kinase activity
K6V30_RS16285	COG0156	8-amino-7-oxononanoate synthase activity
K6V30_RS16315	COG1136	(ABC) transporter
K6V30_RS16335	COG3852	Histidine kinase
K6V30_RS16345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6V30_RS16365	COG0592	DNA-directed DNA polymerase activity
K6V30_RS16380	COG3935	DnaD domain protein
K6V30_RS16730	COG2226	methyltransferase
K6V30_RS16735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6V30_RS16740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6V30_RS16760	COG0560	Phosphoserine phosphatase
K6V30_RS16760	COG3830	Belongs to the UPF0237 family
K6V30_RS16765	COG0513	Belongs to the DEAD box helicase family
K6V30_RS16795	COG0246	Mannitol dehydrogenase
K6V30_RS16800	COG1609	Transcriptional regulator
K6V30_RS16805	COG1904	glucuronate isomerase
K6V30_RS16820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V30_RS16840	COG3015	lipoprotein NlpE involved in copper resistance
K6V30_RS16875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6V30_RS16890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K6V30_RS16900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6V30_RS16910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V30_RS16910	COG3153	acetyltransferase
K6V30_RS16915	COG0798	PFAM Bile acid sodium symporter
K6V30_RS16920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6V30_RS16965	COG2814	Major facilitator Superfamily
K6V30_RS16965	COG0477	Major facilitator Superfamily
K6V30_RS16970	COG2115	Belongs to the xylose isomerase family
K6V30_RS16985	COG0351	phosphomethylpyrimidine kinase
K6V30_RS16990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6V30_RS16995	COG0045	succinate-CoA ligase (ADP-forming) activity
K6V30_RS17000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K6V30_RS17015	COG0174	glutamine synthetase
K6V30_RS17020	COG0724	RNA recognition motif
K6V30_RS17025	COG3279	Response regulator of the LytR AlgR family
K6V30_RS17055	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6V30_RS17065	COG2326	polyphosphate kinase activity
K6V30_RS17075	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6V30_RS17080	COG0348	domain, Protein
K6V30_RS17115	COG2966	Psort location CytoplasmicMembrane, score
K6V30_RS17145	COG3292	Two component regulator propeller
K6V30_RS17145	COG2205	protein histidine kinase activity
K6V30_RS17145	COG0745	RESPONSE REGULATOR receiver
K6V30_RS17150	COG3250	beta-galactosidase activity
K6V30_RS17200	COG0745	RESPONSE REGULATOR receiver
K6V30_RS17210	COG3250	beta-galactosidase activity
K6V30_RS17215	COG3250	beta-galactosidase activity
K6V30_RS17225	COG2205	protein histidine kinase activity
K6V30_RS17235	COG3250	beta-galactosidase activity
K6V30_RS17280	COG2755	lipolytic protein G-D-S-L family
K6V30_RS17280	COG0657	acetylesterase activity
K6V30_RS17285	COG0167	dihydroorotate dehydrogenase activity
K6V30_RS17295	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V30_RS17305	COG3408	Glycogen debranching enzyme
K6V30_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
K6V30_RS17335	COG3408	Glycogen debranching enzyme
K6V30_RS17360	COG0702	epimerase
K6V30_RS17365	COG4206	TonB-dependent receptor
K6V30_RS17365	COG1629	transport
K6V30_RS17375	COG0702	epimerase
K6V30_RS17380	COG1629	transport
K6V30_RS17395	COG3537	Alpha-1,2-mannosidase
K6V30_RS17400	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V30_RS17435	COG4771	TonB-dependent receptor
K6V30_RS17465	COG1629	transport
K6V30_RS17465	COG4206	TonB-dependent receptor
K6V30_RS17490	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS17505	COG1074	ATP-dependent DNA helicase activity
K6V30_RS17510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6V30_RS17580	COG1475	DNA binding
K6V30_RS17585	COG3969	phosphoadenosine phosphosulfate
K6V30_RS17610	COG1678	Uncharacterized ACR, COG1678
K6V30_RS17625	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6V30_RS17635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K6V30_RS17665	COG0321	lipoyl(octanoyl) transferase activity
K6V30_RS17675	COG2217	Heavy metal translocating P-type atpase
K6V30_RS17720	COG0357	Ribosomal RNA small subunit methyltransferase G
K6V30_RS17725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6V30_RS17730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V30_RS17730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V30_RS17735	COG0778	Nitroreductase
K6V30_RS17745	COG1739	Uncharacterized protein family UPF0029
K6V30_RS17760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6V30_RS17765	COG0513	Belongs to the DEAD box helicase family
K6V30_RS17770	COG2871	sodium ion transport
K6V30_RS17775	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V30_RS17785	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V30_RS17790	COG1805	sodium ion transport
K6V30_RS17825	COG1215	transferase activity, transferring glycosyl groups
K6V30_RS17835	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS17870	COG1442	glycosyl transferase family 8
K6V30_RS17870	COG1216	Glycosyl transferase, family 2
K6V30_RS17875	COG2244	polysaccharide biosynthetic process
K6V30_RS17885	COG1442	glycosyl transferase family 8
K6V30_RS17890	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS17895	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS17900	COG1215	transferase activity, transferring glycosyl groups
K6V30_RS17915	COG0784	Response regulator, receiver
K6V30_RS17915	COG2205	protein histidine kinase activity
K6V30_RS17930	COG0488	(ABC) transporter
K6V30_RS17955	COG0657	acetylesterase activity
K6V30_RS17955	COG2755	lipolytic protein G-D-S-L family
K6V30_RS17960	COG0534	Mate efflux family protein
K6V30_RS17965	COG2885	chlorophyll binding
K6V30_RS17970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6V30_RS17985	COG1704	LemA family
K6V30_RS17990	COG0501	Belongs to the peptidase M48B family
K6V30_RS18015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6V30_RS18020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V30_RS18050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS18055	COG1136	(ABC) transporter
K6V30_RS18060	COG1136	(ABC) transporter
K6V30_RS18060	COG0577	efflux transmembrane transporter activity
K6V30_RS18070	COG3279	Response regulator of the LytR AlgR family
K6V30_RS18075	COG2135	peptidase activity
K6V30_RS18080	COG2837	iron assimilation
K6V30_RS18090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6V30_RS18100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6V30_RS18105	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6V30_RS18110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K6V30_RS18115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V30_RS18125	COG0318	PFAM AMP-dependent synthetase and ligase
K6V30_RS18135	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K6V30_RS18140	COG2985	domain, Protein
K6V30_RS18140	COG0490	domain, Protein
K6V30_RS18180	COG0737	Belongs to the 5'-nucleotidase family
K6V30_RS18185	COG2202	Pas domain
K6V30_RS18185	COG2205	protein histidine kinase activity
K6V30_RS18190	COG2183	response to ionizing radiation
K6V30_RS18235	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS18260	COG0488	(ABC) transporter
K6V30_RS18265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6V30_RS18270	COG0484	heat shock protein binding
K6V30_RS18285	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V30_RS18290	COG4771	TonB-dependent receptor
K6V30_RS18310	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS18330	COG1216	Glycosyl transferase, family 2
K6V30_RS18350	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6V30_RS18380	COG3250	beta-galactosidase activity
K6V30_RS18385	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS18390	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS18400	COG2755	lipolytic protein G-D-S-L family
K6V30_RS18400	COG0657	acetylesterase activity
K6V30_RS18405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS18430	COG1629	transport
K6V30_RS18510	COG0561	phosphatase activity
K6V30_RS18515	COG4771	TonB-dependent receptor
K6V30_RS18525	COG2814	Major facilitator Superfamily
K6V30_RS18540	COG1940	carbohydrate kinase activity
K6V30_RS18555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6V30_RS18565	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6V30_RS18565	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6V30_RS18565	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K6V30_RS18565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6V30_RS18570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V30_RS18575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V30_RS18585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K6V30_RS18590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6V30_RS18595	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K6V30_RS18600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6V30_RS18610	COG0242	peptide deformylase activity
K6V30_RS18615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6V30_RS18635	COG2895	sulfate adenylyltransferase (ATP) activity
K6V30_RS18640	COG0175	sulfate reduction
K6V30_RS18645	COG0529	Catalyzes the synthesis of activated sulfate
K6V30_RS18650	COG3273	potassium ion transport
K6V30_RS18650	COG0471	metal ion transport
K6V30_RS18665	COG4221	oxidoreductase activity
K6V30_RS18705	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS18760	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS18765	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS18855	COG0504	CTP synthase activity
K6V30_RS18860	COG0706	membrane insertase activity
K6V30_RS18865	COG0534	Mate efflux family protein
K6V30_RS18870	COG0823	Involved in the tonB-independent uptake of proteins
K6V30_RS18870	COG1506	peptidase
K6V30_RS18890	COG1983	PspC domain protein
K6V30_RS18895	COG1695	Transcriptional regulator
K6V30_RS18905	COG3104	oligopeptide transport
K6V30_RS18910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6V30_RS18920	COG1388	LysM domain
K6V30_RS18920	COG3942	CHAP domain
K6V30_RS18950	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V30_RS18955	COG0556	nucleotide-excision repair
K6V30_RS18995	COG0842	Transport permease protein
K6V30_RS19000	COG0842	Transport permease protein
K6V30_RS19005	COG1131	(ABC) transporter
K6V30_RS19010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS19020	COG1917	Cupin 2, conserved barrel domain protein
K6V30_RS19020	COG2207	Transcriptional regulator
K6V30_RS19025	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K6V30_RS19025	COG0662	Cupin 2, conserved barrel domain protein
K6V30_RS19030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V30_RS19035	COG0505	Belongs to the CarA family
K6V30_RS19045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6V30_RS19050	COG0067	glutamate synthase
K6V30_RS19050	COG0070	glutamate synthase
K6V30_RS19050	COG0069	glutamate synthase activity
K6V30_RS19060	COG0367	asparagine synthase
K6V30_RS19080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K6V30_RS19085	COG0436	Aminotransferase
K6V30_RS19095	COG0347	Belongs to the P(II) protein family
K6V30_RS19100	COG0004	ammonium transporteR
K6V30_RS19115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6V30_RS19125	COG0471	metal ion transport
K6V30_RS19125	COG0490	domain, Protein
K6V30_RS19130	COG0784	Response regulator, receiver
K6V30_RS19130	COG2205	protein histidine kinase activity
K6V30_RS19135	COG1979	alcohol dehydrogenase
K6V30_RS19145	COG0133	tryptophan synthase activity
K6V30_RS19150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6V30_RS19160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6V30_RS19165	COG0134	indole-3-glycerol-phosphate synthase activity
K6V30_RS19170	COG0135	phosphoribosylanthranilate isomerase activity
K6V30_RS19175	COG0159	tryptophan synthase activity
K6V30_RS19180	COG0252	asparaginase activity
K6V30_RS19190	COG2205	protein histidine kinase activity
K6V30_RS19190	COG3292	Two component regulator propeller
K6V30_RS19190	COG0745	RESPONSE REGULATOR receiver
K6V30_RS19195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V30_RS19205	COG0110	maltose O-acetyltransferase activity
K6V30_RS19210	COG2197	response regulator
K6V30_RS19220	COG0138	bifunctional purine biosynthesis protein purh
K6V30_RS19225	COG0716	FMN binding
K6V30_RS19250	COG1132	(ABC) transporter
K6V30_RS19265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS19270	COG4771	TonB-dependent receptor
K6V30_RS19280	COG4771	TonB-dependent receptor
K6V30_RS19290	COG0490	domain, Protein
K6V30_RS19290	COG2985	domain, Protein
K6V30_RS19300	COG0612	Peptidase, M16
K6V30_RS19315	COG4206	TonB-dependent receptor
K6V30_RS19315	COG1629	transport
K6V30_RS19320	COG1230	cation diffusion facilitator family transporter
K6V30_RS19335	COG4771	TonB-dependent receptor
K6V30_RS19375	COG1609	Transcriptional regulator
K6V30_RS19380	COG2721	sulfolactate sulfo-lyase activity
K6V30_RS19430	COG1073	alpha beta
K6V30_RS19455	COG1733	regulation of RNA biosynthetic process
K6V30_RS19470	COG0784	Response regulator, receiver
K6V30_RS19470	COG2205	protein histidine kinase activity
K6V30_RS19480	COG3275	phosphorelay sensor kinase activity
K6V30_RS19505	COG0228	four-way junction DNA binding
K6V30_RS19510	COG2188	Transcriptional regulator
K6V30_RS19515	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
K6V30_RS19525	COG1070	Carbohydrate kinase
K6V30_RS19535	COG0738	Major facilitator superfamily
K6V30_RS19550	COG4771	TonB-dependent receptor
K6V30_RS19580	COG2207	Transcriptional regulator
K6V30_RS19600	COG1177	transmembrane transport
K6V30_RS19605	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6V30_RS19610	COG3842	ATPase activity
K6V30_RS19615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V30_RS19620	COG0058	SHG alpha-glucan phosphorylase activity
K6V30_RS19630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V30_RS19650	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K6V30_RS19675	COG1725	Transcriptional regulator
K6V30_RS19685	COG1131	(ABC) transporter
K6V30_RS19730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6V30_RS19735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V30_RS19740	COG4948	Mandelate Racemase Muconate Lactonizing
K6V30_RS19755	COG1295	ribonuclease BN
K6V30_RS19770	COG0704	Plays a role in the regulation of phosphate uptake
K6V30_RS19775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6V30_RS19780	COG0581	inorganic phosphate transmembrane transporter activity
K6V30_RS19785	COG0573	inorganic phosphate transmembrane transporter activity
K6V30_RS19795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V30_RS19805	COG0586	Pfam SNARE associated Golgi protein
K6V30_RS19815	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6V30_RS19830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6V30_RS19835	COG0167	dihydroorotate dehydrogenase activity
K6V30_RS19840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6V30_RS19890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V30_RS19910	COG1215	transferase activity, transferring glycosyl groups
K6V30_RS19945	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6V30_RS19980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6V30_RS19985	COG0497	DNA recombination
K6V30_RS20000	COG0592	DNA-directed DNA polymerase activity
K6V30_RS20015	COG0321	lipoyl(octanoyl) transferase activity
K6V30_RS20015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V30_RS20020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6V30_RS20030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V30_RS20035	COG0156	8-amino-7-oxononanoate synthase activity
K6V30_RS20045	COG0784	Response regulator, receiver
K6V30_RS20045	COG2205	protein histidine kinase activity
K6V30_RS20060	COG0019	diaminopimelate decarboxylase activity
K6V30_RS20065	COG0527	aspartate kinase activity
K6V30_RS20070	COG2884	Cell division ATP-binding protein ftsE
K6V30_RS20075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6V30_RS20075	COG0140	phosphoribosyl-ATP diphosphatase activity
K6V30_RS20080	COG0107	imidazoleglycerol-phosphate synthase activity
K6V30_RS20085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6V30_RS20090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6V30_RS20095	COG0788	formyltetrahydrofolate deformylase activity
K6V30_RS20160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6V30_RS20180	COG0693	protein deglycase activity
K6V30_RS20205	COG0534	Mate efflux family protein
K6V30_RS20210	COG2076	Multidrug Resistance protein
K6V30_RS20255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6V30_RS20275	COG2814	Major facilitator Superfamily
K6V30_RS20310	COG1309	transcriptional regulator
K6V30_RS20320	COG0823	Involved in the tonB-independent uptake of proteins
K6V30_RS20320	COG1506	peptidase
K6V30_RS20320	COG4946	Tricorn protease homolog
K6V30_RS20335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6V30_RS20340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6V30_RS20355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V30_RS20365	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K6V30_RS20380	COG4771	TonB-dependent receptor
K6V30_RS20430	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K6V30_RS20455	COG1312	Catalyzes the dehydration of D-mannonate
K6V30_RS20460	COG1028	Short-chain dehydrogenase reductase Sdr
K6V30_RS20465	COG1609	Transcriptional regulator
K6V30_RS20480	COG1929	Belongs to the glycerate kinase type-1 family
K6V30_RS20485	COG2223	nitrite transmembrane transporter activity
K6V30_RS20495	COG4771	TonB-dependent receptor
K6V30_RS20505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6V30_RS20505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6V30_RS20520	COG2226	methyltransferase
K6V30_RS20530	COG0784	Response regulator, receiver
K6V30_RS20530	COG2205	protein histidine kinase activity
K6V30_RS20535	COG0511	ligase activity, forming carbon-carbon bonds
K6V30_RS20540	COG0439	Biotin carboxylase
K6V30_RS20545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V30_RS20560	COG1620	l-lactate permease
K6V30_RS20575	COG1819	glycosyl
K6V30_RS20585	COG3279	Response regulator of the LytR AlgR family
K6V30_RS20605	COG0110	maltose O-acetyltransferase activity
K6V30_RS20620	COG0628	permease
K6V30_RS20625	COG1215	transferase activity, transferring glycosyl groups
K6V30_RS20635	COG0189	ligase activity
K6V30_RS20635	COG0569	domain protein
K6V30_RS20640	COG0577	efflux transmembrane transporter activity
K6V30_RS20640	COG1136	(ABC) transporter
K6V30_RS20645	COG0436	Aminotransferase
K6V30_RS20660	COG0488	(ABC) transporter
K6V30_RS20675	COG0745	RESPONSE REGULATOR receiver
K6V30_RS20705	COG4206	TonB-dependent receptor
K6V30_RS20720	COG3033	Beta-eliminating lyase
K6V30_RS20745	COG0629	single-stranded DNA binding
K6V30_RS20750	COG1194	a g-specific adenine glycosylase
K6V30_RS20760	COG1530	ribonuclease E activity
K6V30_RS20765	COG2885	chlorophyll binding
K6V30_RS20805	COG0305	Participates in initiation and elongation during chromosome replication
K6V30_RS20810	COG0776	regulation of translation
K6V30_RS20820	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS20825	COG3177	Filamentation induced by cAMP protein fic
K6V30_RS20835	COG4974	Belongs to the 'phage' integrase family
K6V30_RS20905	COG0784	Response regulator, receiver
K6V30_RS20905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V30_RS20905	COG2205	protein histidine kinase activity
K6V30_RS20905	COG2198	Histidine kinase
K6V30_RS21110	COG1979	alcohol dehydrogenase
K6V30_RS21125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6V30_RS21135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6V30_RS21150	COG4191	Histidine kinase
K6V30_RS21155	COG2204	response regulator
K6V30_RS21165	COG5002	protein histidine kinase activity
K6V30_RS21165	COG0784	Response regulator, receiver
K6V30_RS21165	COG2205	protein histidine kinase activity
K6V30_RS21170	COG1136	(ABC) transporter
K6V30_RS21170	COG0577	efflux transmembrane transporter activity
K6V30_RS21175	COG0577	efflux transmembrane transporter activity
K6V30_RS21175	COG1136	(ABC) transporter
K6V30_RS21185	COG1136	(ABC) transporter
K6V30_RS21195	COG1252	NADH dehydrogenase
K6V30_RS21200	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6V30_RS21215	COG3059	membrane
K6V30_RS21220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V30_RS21225	COG0488	(ABC) transporter
K6V30_RS21300	COG0745	RESPONSE REGULATOR receiver
K6V30_RS21300	COG2205	protein histidine kinase activity
K6V30_RS21300	COG3292	Two component regulator propeller
K6V30_RS21305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V30_RS21315	COG0739	heme binding
K6V30_RS21320	COG0686	Belongs to the AlaDH PNT family
K6V30_RS21360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6V30_RS21390	COG1487	ribonuclease activity
K6V30_RS21395	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6V30_RS21400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6V30_RS21430	COG1595	DNA-templated transcription, initiation
K6V30_RS21445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V30_RS21450	COG1741	Belongs to the pirin family
K6V30_RS21455	COG0259	pyridoxamine-phosphate oxidase activity
K6V30_RS21500	COG0697	spore germination
K6V30_RS21505	COG0456	acetyltransferase
K6V30_RS21540	COG1918	ferrous iron import across plasma membrane
K6V30_RS21540	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6V30_RS21545	COG0037	tRNA processing
K6V30_RS21560	COG3119	arylsulfatase activity
K6V30_RS21565	COG2202	Pas domain
K6V30_RS21565	COG2205	protein histidine kinase activity
K6V30_RS21570	COG2205	protein histidine kinase activity
K6V30_RS21575	COG0534	Mate efflux family protein
K6V30_RS21580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6V30_RS21590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6V30_RS21640	COG3250	beta-galactosidase activity
K6V30_RS21670	COG0514	ATP-dependent DNA helicase (RecQ)
K6V30_RS21710	COG2885	chlorophyll binding
K6V30_RS21725	COG1983	PspC domain protein
K6V30_RS21735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6V30_RS21760	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V30_RS21770	COG0668	transmembrane transport
K6V30_RS21775	COG3119	arylsulfatase activity
K6V30_RS21785	COG3250	beta-galactosidase activity
K6V30_RS21790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V30_RS21795	COG3119	arylsulfatase activity
K6V30_RS21810	COG4206	TonB-dependent receptor
K6V30_RS21810	COG1629	transport
K6V30_RS21820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K6V30_RS21825	COG1660	Displays ATPase and GTPase activities
K6V30_RS21830	COG2205	protein histidine kinase activity
K6V30_RS21830	COG2205	protein histidine kinase activity
K6V30_RS21830	COG3292	Two component regulator propeller
K6V30_RS21830	COG3292	Two component regulator propeller
K6V30_RS21830	COG0745	RESPONSE REGULATOR receiver
K6V30_RS21830	COG0745	RESPONSE REGULATOR receiver
K6V30_RS21835	COG3119	arylsulfatase activity
K6V30_RS21845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6V30_RS21850	COG1830	Aldolase
K6V30_RS21855	COG0588	phosphoglycerate mutase activity
K6V30_RS21865	COG1119	ATPase activity
K6V30_RS21870	COG1523	belongs to the glycosyl hydrolase 13 family
K6V30_RS21875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6V30_RS21910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6V30_RS21915	COG2814	Major facilitator Superfamily
K6V30_RS21920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6V30_RS21925	COG0126	phosphoglycerate kinase activity
K6V30_RS21945	COG0424	maF-like protein
K6V30_RS21965	COG0778	Nitroreductase
K6V30_RS21975	COG0288	reversible hydration of carbon dioxide
K6V30_RS21985	COG4771	TonB-dependent receptor
K6V30_RS22000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V30_RS22010	COG0511	ligase activity, forming carbon-carbon bonds
K6V30_RS22015	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6V30_RS22025	COG0191	fructose-bisphosphate aldolase activity
K6V30_RS22030	COG0254	rRNA binding
K6V30_RS22035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS22115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V30_RS22125	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS22130	COG1216	Glycosyl transferase, family 2
K6V30_RS22130	COG1442	glycosyl transferase family 8
K6V30_RS22160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K6V30_RS22210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K6V30_RS22225	COG1280	lysine exporter protein (LysE YggA)
K6V30_RS22235	COG3292	Two component regulator propeller
K6V30_RS22235	COG2205	protein histidine kinase activity
K6V30_RS22235	COG0745	RESPONSE REGULATOR receiver
K6V30_RS22235	COG3292	Two component regulator propeller
K6V30_RS22235	COG0745	RESPONSE REGULATOR receiver
K6V30_RS22235	COG2205	protein histidine kinase activity
K6V30_RS22250	COG1649	PFAM Uncharacterised BCR, COG1649
K6V30_RS22275	COG1966	Carbon starvation protein
K6V30_RS22285	COG1649	PFAM Uncharacterised BCR, COG1649
K6V30_RS22320	COG2113	Glycine betaine
K6V30_RS22325	COG4176	ABC-type proline glycine betaine transport system permease component
K6V30_RS22345	COG0745	RESPONSE REGULATOR receiver
K6V30_RS22345	COG2205	protein histidine kinase activity
K6V30_RS22345	COG3292	Two component regulator propeller
K6V30_RS22350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6V30_RS22350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6V30_RS22360	COG1621	beta-fructofuranosidase activity
K6V30_RS22365	COG0702	epimerase
K6V30_RS22385	COG0475	glutathione-regulated potassium exporter activity
K6V30_RS22420	COG3279	Response regulator of the LytR AlgR family
K6V30_RS22440	COG4772	TonB-dependent receptor
K6V30_RS22455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6V30_RS22460	COG1960	acyl-CoA dehydrogenase activity
K6V30_RS22480	COG1956	GAF domain-containing protein
K6V30_RS22490	COG0484	heat shock protein binding
K6V30_RS22495	COG2194	sulfuric ester hydrolase activity
K6V30_RS22530	COG0028	Belongs to the TPP enzyme family
K6V30_RS22550	COG2885	chlorophyll binding
K6V30_RS22565	COG0459	protein refolding
K6V30_RS22570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6V30_RS22605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6V30_RS22615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6V30_RS22620	COG1506	peptidase
K6V30_RS22620	COG0823	Involved in the tonB-independent uptake of proteins
K6V30_RS22630	COG2818	Glycosylase
K6V30_RS22635	COG0124	histidyl-tRNA synthetase
K6V30_RS22650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6V30_RS22675	COG0514	ATP-dependent DNA helicase (RecQ)
K6V30_RS22690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6V30_RS22700	COG0671	phosphoesterase, PA-phosphatase related
K6V30_RS22715	COG0473	3-isopropylmalate dehydrogenase activity
K6V30_RS22725	COG0066	3-isopropylmalate dehydratase activity
K6V30_RS22730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6V30_RS22735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6V30_RS22805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V30_RS22805	COG0784	Response regulator, receiver
K6V30_RS22965	COG1475	DNA binding
K6V30_RS23065	COG0784	Response regulator, receiver
K6V30_RS23065	COG2198	Histidine kinase
K6V30_RS23065	COG5002	protein histidine kinase activity
K6V30_RS23130	COG4948	Mandelate Racemase Muconate Lactonizing
K6V30_RS23145	COG0702	epimerase
K6V30_RS23150	COG4771	TonB-dependent receptor
K6V30_RS23170	COG0616	signal peptide processing
K6V30_RS23175	COG1663	tetraacyldisaccharide 4'-kinase activity
K6V30_RS23185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6V30_RS23395	COG1192	Involved in chromosome partitioning
K6V30_RS23515	COG0542	response to heat
K6V30_RS23545	COG3209	COG3209 Rhs family protein
K6V30_RS23570	COG3209	COG3209 Rhs family protein
K6V30_RS23610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V30_RS23620	COG0784	Response regulator, receiver
K6V30_RS23620	COG2205	protein histidine kinase activity
K6V30_RS23645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6V30_RS23645	COG0551	DNA topoisomerase type I activity
K6V30_RS23735	COG0513	Belongs to the DEAD box helicase family
K6V30_RS23740	COG2070	2-Nitropropane dioxygenase
K6V30_RS23745	COG0724	RNA recognition motif
K6V30_RS23760	COG3973	AAA domain
K6V30_RS23800	COG1704	LemA family
K6V30_RS23815	COG0534	Mate efflux family protein
K6V30_RS23830	COG1917	Cupin 2, conserved barrel domain protein
K6V30_RS23830	COG4977	sequence-specific DNA binding
K6V30_RS23860	COG1028	Short-chain dehydrogenase reductase Sdr
K6V30_RS23865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6V30_RS23875	COG0439	Biotin carboxylase
K6V30_RS23885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V30_RS23910	COG2873	o-acetylhomoserine
K6V30_RS23920	COG3292	Two component regulator propeller
K6V30_RS23920	COG2205	protein histidine kinase activity
K6V30_RS23920	COG0745	RESPONSE REGULATOR receiver
K6V30_RS23925	COG3250	beta-galactosidase activity
K6V30_RS23975	COG2217	Heavy metal translocating P-type atpase
K6V30_RS23980	COG1538	Outer membrane efflux protein
K6V30_RS23990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS24000	COG2814	Major facilitator Superfamily
K6V30_RS24030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6V30_RS24050	COG0024	Methionine aminopeptidase
K6V30_RS24055	COG0617	tRNA 3'-terminal CCA addition
K6V30_RS24075	COG0632	four-way junction helicase activity
K6V30_RS24080	COG0673	inositol 2-dehydrogenase activity
K6V30_RS24105	COG1272	protein, Hemolysin III
K6V30_RS24145	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6V30_RS24170	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS24205	COG1328	CTP reductase activity
K6V30_RS24215	COG2814	Major facilitator Superfamily
K6V30_RS24225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V30_RS24240	COG0750	zinc metalloprotease
K6V30_RS24245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6V30_RS24255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6V30_RS24260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6V30_RS24350	COG2020	methyltransferase activity
K6V30_RS24355	COG4735	regulation of single-species biofilm formation
K6V30_RS24410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V30_RS24415	COG0438	transferase activity, transferring glycosyl groups
K6V30_RS24500	COG1086	Polysaccharide biosynthesis protein
K6V30_RS24550	COG0194	GDP metabolic process
K6V30_RS24560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6V30_RS24565	COG1408	metallophosphoesterase
K6V30_RS24570	COG1575	Belongs to the MenA family. Type 1 subfamily
K6V30_RS24575	COG1088	dTDP-glucose 4,6-dehydratase activity
K6V30_RS24580	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6V30_RS24590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6V30_RS24600	COG4771	TonB-dependent receptor
K6V30_RS24605	COG1629	transport
K6V30_RS24605	COG4206	TonB-dependent receptor
K6V30_RS24620	COG0784	Response regulator, receiver
K6V30_RS24620	COG2205	protein histidine kinase activity
K6V30_RS24625	COG0488	(ABC) transporter
K6V30_RS24675	COG1595	DNA-templated transcription, initiation
K6V30_RS24690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6V30_RS24700	COG1522	sequence-specific DNA binding
K6V30_RS24730	COG0811	peptide transport
K6V30_RS24740	COG0084	hydrolase, TatD family'
K6V30_RS24760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6V30_RS24765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6V30_RS24770	COG0205	6-phosphofructokinase activity
K6V30_RS24800	COG0372	Belongs to the citrate synthase family
K6V30_RS24805	COG0538	isocitrate dehydrogenase activity
K6V30_RS24810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6V30_RS24815	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K6V30_RS24820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6V30_RS24840	COG0028	Belongs to the TPP enzyme family
K6V30_RS24845	COG0129	dihydroxy-acid dehydratase activity
K6V30_RS24850	COG1047	Peptidyl-prolyl cis-trans
K6V30_RS24855	COG3681	Belongs to the UPF0597 family
K6V30_RS24875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6V30_RS24905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V30_RS24905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V30_RS24910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V30_RS24915	COG0569	domain protein
K6V30_RS24915	COG2985	domain, Protein
K6V30_RS24925	COG1492	cobalamin metabolic process
K6V30_RS24965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6V30_RS24980	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K6V30_RS25000	COG0534	Mate efflux family protein
K6V30_RS25055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V30_RS25060	COG1609	Transcriptional regulator
K6V30_RS25060	COG2207	Transcriptional regulator
K6V30_RS25070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6V30_RS25080	COG0166	Belongs to the GPI family
K6V30_RS25110	COG2502	aspartate--ammonia ligase
K6V30_RS25115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6V30_RS25130	COG3876	Protein conserved in bacteria
K6V30_RS25145	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6V30_RS25225	COG2205	protein histidine kinase activity
K6V30_RS25225	COG2202	Pas domain