locus-tag	class	description
BF638R_RS00020	COG1215	transferase activity, transferring glycosyl groups
BF638R_RS00070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BF638R_RS00070	COG0731	radical SAM domain protein
BF638R_RS00095	COG0659	secondary active sulfate transmembrane transporter activity
BF638R_RS00100	COG1592	Rubrerythrin
BF638R_RS00105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BF638R_RS00125	COG0427	acetyl-CoA hydrolase
BF638R_RS00135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BF638R_RS00145	COG3250	beta-galactosidase activity
BF638R_RS00225	COG2177	Part of the ABC transporter FtsEX involved in
BF638R_RS00240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BF638R_RS00245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BF638R_RS00250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BF638R_RS00255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BF638R_RS00260	COG1611	Belongs to the LOG family
BF638R_RS00275	COG0594	ribonuclease P activity
BF638R_RS00285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BF638R_RS00290	COG0823	Involved in the tonB-independent uptake of proteins
BF638R_RS00290	COG1506	peptidase
BF638R_RS00290	COG4946	Tricorn protease homolog
BF638R_RS00300	COG3119	arylsulfatase activity
BF638R_RS00305	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BF638R_RS00310	COG1028	Short-chain dehydrogenase reductase Sdr
BF638R_RS00320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BF638R_RS00345	COG1121	(ABC) transporter
BF638R_RS00355	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BF638R_RS00355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF638R_RS00370	COG0151	Belongs to the GarS family
BF638R_RS00375	COG0823	Involved in the tonB-independent uptake of proteins
BF638R_RS00375	COG1506	peptidase
BF638R_RS00380	COG0116	Belongs to the methyltransferase superfamily
BF638R_RS00385	COG1045	serine acetyltransferase
BF638R_RS00390	COG3275	phosphorelay sensor kinase activity
BF638R_RS00395	COG3279	Response regulator of the LytR AlgR family
BF638R_RS00405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF638R_RS00405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF638R_RS00420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BF638R_RS00425	COG1694	Mazg nucleotide pyrophosphohydrolase
BF638R_RS00435	COG0322	excinuclease ABC activity
BF638R_RS00440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BF638R_RS00470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BF638R_RS00490	COG2715	membrane protein required for spore maturation
BF638R_RS00500	COG2255	four-way junction helicase activity
BF638R_RS00515	COG3591	Belongs to the peptidase S1B family
BF638R_RS00530	COG0513	Belongs to the DEAD box helicase family
BF638R_RS00540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BF638R_RS00555	COG0612	Peptidase, M16
BF638R_RS00570	COG1312	Catalyzes the dehydration of D-mannonate
BF638R_RS00575	COG1028	Short-chain dehydrogenase reductase Sdr
BF638R_RS00585	COG0681	Belongs to the peptidase S26 family
BF638R_RS00590	COG0681	Belongs to the peptidase S26 family
BF638R_RS00595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BF638R_RS00625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF638R_RS00640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF638R_RS00645	COG3250	beta-galactosidase activity
BF638R_RS00665	COG0215	cysteine-tRNA ligase activity
BF638R_RS00670	COG0561	phosphatase activity
BF638R_RS00710	COG0745	RESPONSE REGULATOR receiver
BF638R_RS00715	COG5002	protein histidine kinase activity
BF638R_RS00720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BF638R_RS00735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BF638R_RS00750	COG0205	6-phosphofructokinase activity
BF638R_RS00755	COG0571	ribonuclease III activity
BF638R_RS00760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BF638R_RS00765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BF638R_RS00770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BF638R_RS00775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BF638R_RS00790	COG1442	glycosyl transferase family 8
BF638R_RS00800	COG1215	transferase activity, transferring glycosyl groups
BF638R_RS00805	COG1442	glycosyl transferase family 8
BF638R_RS00805	COG1216	Glycosyl transferase, family 2
BF638R_RS00810	COG1132	(ABC) transporter
BF638R_RS00820	COG0328	RNA-DNA hybrid ribonuclease activity
BF638R_RS00820	COG3341	Caulimovirus viroplasmin
BF638R_RS00835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BF638R_RS00845	COG0326	Molecular chaperone. Has ATPase activity
BF638R_RS00855	COG1166	arginine decarboxylase activity
BF638R_RS00860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BF638R_RS00920	COG0582	viral genome integration into host DNA
BF638R_RS00960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF638R_RS00960	COG0551	DNA topoisomerase type I activity
BF638R_RS00980	COG4771	TonB-dependent receptor
BF638R_RS00995	COG1132	(ABC) transporter
BF638R_RS01000	COG1132	(ABC) transporter
BF638R_RS01000	COG2375	cellular response to nickel ion
BF638R_RS01140	COG0358	DNA primase activity
BF638R_RS01220	COG1454	alcohol dehydrogenase
BF638R_RS01225	COG0235	Class ii aldolase
BF638R_RS01230	COG1070	Carbohydrate kinase
BF638R_RS01235	COG0738	Major facilitator superfamily
BF638R_RS01255	COG0779	Required for maturation of 30S ribosomal subunits
BF638R_RS01260	COG0195	Participates in both transcription termination and antitermination
BF638R_RS01265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BF638R_RS01275	COG0719	Fe-S assembly protein
BF638R_RS01285	COG0396	ATPase activity
BF638R_RS01290	COG0719	Fe-S assembly protein
BF638R_RS01295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BF638R_RS01300	COG0393	Putative heavy-metal-binding
BF638R_RS01305	COG3345	alpha-galactosidase
BF638R_RS01315	COG1629	transport
BF638R_RS01340	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BF638R_RS01345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BF638R_RS01360	COG2202	Pas domain
BF638R_RS01360	COG2205	protein histidine kinase activity
BF638R_RS01380	COG0187	DNA topoisomerase II activity
BF638R_RS01385	COG0268	Binds directly to 16S ribosomal RNA
BF638R_RS01395	COG1381	Involved in DNA repair and RecF pathway recombination
BF638R_RS01400	COG1610	YqeY-like protein
BF638R_RS01405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BF638R_RS01420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BF638R_RS01425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BF638R_RS01430	COG0772	Belongs to the SEDS family
BF638R_RS01435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BF638R_RS01440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF638R_RS01445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BF638R_RS01465	COG2001	Belongs to the MraZ family
BF638R_RS01505	COG4771	TonB-dependent receptor
BF638R_RS01530	COG0756	dUTP diphosphatase activity
BF638R_RS01545	COG4942	peptidase
BF638R_RS01550	COG2205	protein histidine kinase activity
BF638R_RS01550	COG3292	Two component regulator propeller
BF638R_RS01550	COG0745	RESPONSE REGULATOR receiver
BF638R_RS01555	COG3940	Belongs to the glycosyl hydrolase 43 family
BF638R_RS01570	COG3250	beta-galactosidase activity
BF638R_RS01585	COG3940	Belongs to the glycosyl hydrolase 43 family
BF638R_RS01605	COG0383	alpha-mannosidase activity
BF638R_RS01605	COG0383	alpha-mannosidase activity
BF638R_RS01610	COG1629	transport
BF638R_RS01610	COG4206	TonB-dependent receptor
BF638R_RS01630	COG3507	Belongs to the glycosyl hydrolase 43 family
BF638R_RS01655	COG3537	Alpha-1,2-mannosidase
BF638R_RS01665	COG2017	converts alpha-aldose to the beta-anomer
BF638R_RS01745	COG3408	Glycogen debranching enzyme
BF638R_RS01750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BF638R_RS01755	COG1022	Amp-dependent synthetase and ligase
BF638R_RS01775	COG2954	triphosphatase activity
BF638R_RS01795	COG3250	beta-galactosidase activity
BF638R_RS01800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS01810	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BF638R_RS01825	COG1629	transport
BF638R_RS01825	COG4206	TonB-dependent receptor
BF638R_RS01830	COG0745	RESPONSE REGULATOR receiver
BF638R_RS01830	COG2205	protein histidine kinase activity
BF638R_RS01830	COG3292	Two component regulator propeller
BF638R_RS01835	COG3292	Two component regulator propeller
BF638R_RS01835	COG2205	protein histidine kinase activity
BF638R_RS01835	COG0745	RESPONSE REGULATOR receiver
BF638R_RS01860	COG4771	TonB-dependent receptor
BF638R_RS01895	COG4771	TonB-dependent receptor
BF638R_RS01920	COG0423	glycine-tRNA ligase activity
BF638R_RS01925	COG0545	Peptidyl-prolyl cis-trans isomerase
BF638R_RS01950	COG3005	denitrification pathway
BF638R_RS01955	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BF638R_RS01980	COG4771	TonB-dependent receptor
BF638R_RS01985	COG2205	protein histidine kinase activity
BF638R_RS01985	COG2205	protein histidine kinase activity
BF638R_RS01985	COG3292	Two component regulator propeller
BF638R_RS01985	COG0745	RESPONSE REGULATOR receiver
BF638R_RS01985	COG3292	Two component regulator propeller
BF638R_RS01985	COG0745	RESPONSE REGULATOR receiver
BF638R_RS01995	COG3005	denitrification pathway
BF638R_RS02000	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BF638R_RS02010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BF638R_RS02050	COG3876	Protein conserved in bacteria
BF638R_RS02085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF638R_RS02090	COG3876	Protein conserved in bacteria
BF638R_RS02095	COG0702	epimerase
BF638R_RS02100	COG4206	TonB-dependent receptor
BF638R_RS02100	COG1629	transport
BF638R_RS02115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BF638R_RS02120	COG0589	response to stress
BF638R_RS02120	COG0475	glutathione-regulated potassium exporter activity
BF638R_RS02125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BF638R_RS02130	COG1136	(ABC) transporter
BF638R_RS02140	COG0733	neurotransmitter:sodium symporter activity
BF638R_RS02150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BF638R_RS02160	COG0076	glutamate decarboxylase activity
BF638R_RS02165	COG2066	Belongs to the glutaminase family
BF638R_RS02170	COG2198	Histidine kinase
BF638R_RS02170	COG5002	protein histidine kinase activity
BF638R_RS02170	COG0784	Response regulator, receiver
BF638R_RS02175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BF638R_RS02180	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BF638R_RS02280	COG1346	cytolysis
BF638R_RS02305	COG0280	phosphate acetyltransferase
BF638R_RS02310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BF638R_RS02315	COG1785	Belongs to the alkaline phosphatase family
BF638R_RS02320	COG2151	metal-sulfur cluster biosynthetic enzyme
BF638R_RS02325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF638R_RS02330	COG2003	Belongs to the UPF0758 family
BF638R_RS02335	COG0463	Glycosyl transferase, family 2
BF638R_RS02335	COG1216	Glycosyl transferase, family 2
BF638R_RS02350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BF638R_RS02355	COG0515	serine threonine protein kinase
BF638R_RS02355	COG2815	serine threonine protein kinase
BF638R_RS02360	COG0564	pseudouridine synthase activity
BF638R_RS02400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BF638R_RS02405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BF638R_RS02415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BF638R_RS02435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BF638R_RS02445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BF638R_RS02445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BF638R_RS02450	COG2890	protein-(glutamine-N5) methyltransferase activity
BF638R_RS02455	COG2137	regulation of response to DNA damage stimulus
BF638R_RS02460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BF638R_RS02470	COG0165	Argininosuccinate lyase
BF638R_RS02495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BF638R_RS02500	COG1396	sequence-specific DNA binding
BF638R_RS02500	COG1917	Cupin 2, conserved barrel domain protein
BF638R_RS02505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF638R_RS02510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BF638R_RS02520	COG0137	argininosuccinate synthase activity
BF638R_RS02545	COG2205	protein histidine kinase activity
BF638R_RS02545	COG3437	response regulator, receiver
BF638R_RS02545	COG3850	Histidine kinase
BF638R_RS02545	COG4999	Histidine kinase
BF638R_RS02550	COG0531	amino acid
BF638R_RS02560	COG0039	L-malate dehydrogenase activity
BF638R_RS02565	COG2996	Protein conserved in bacteria
BF638R_RS02585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF638R_RS02590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BF638R_RS02615	COG1629	transport
BF638R_RS02640	COG1136	(ABC) transporter
BF638R_RS02640	COG0577	efflux transmembrane transporter activity
BF638R_RS02645	COG1136	(ABC) transporter
BF638R_RS02645	COG0577	efflux transmembrane transporter activity
BF638R_RS02650	COG1136	(ABC) transporter
BF638R_RS02655	COG1940	carbohydrate kinase activity
BF638R_RS02660	COG0335	large ribosomal subunit rRNA binding
BF638R_RS02665	COG0737	Belongs to the 5'-nucleotidase family
BF638R_RS02670	COG0737	Belongs to the 5'-nucleotidase family
BF638R_RS02675	COG1472	Belongs to the glycosyl hydrolase 3 family
BF638R_RS02680	COG1472	Belongs to the glycosyl hydrolase 3 family
BF638R_RS02685	COG1629	transport
BF638R_RS02685	COG4206	TonB-dependent receptor
BF638R_RS02695	COG3119	arylsulfatase activity
BF638R_RS02720	COG0446	pyridine nucleotide-disulphide oxidoreductase
BF638R_RS02730	COG2204	response regulator
BF638R_RS02735	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BF638R_RS02755	COG2205	protein histidine kinase activity
BF638R_RS02760	COG5002	protein histidine kinase activity
BF638R_RS02775	COG4771	TonB-dependent receptor
BF638R_RS02820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BF638R_RS02820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BF638R_RS02825	COG0436	Aminotransferase
BF638R_RS02830	COG3250	beta-galactosidase activity
BF638R_RS02845	COG0826	peptidase U32
BF638R_RS02855	COG4771	TonB-dependent receptor
BF638R_RS02860	COG2197	response regulator
BF638R_RS02865	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BF638R_RS02875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BF638R_RS02880	COG0252	asparaginase activity
BF638R_RS02885	COG0527	aspartate kinase activity
BF638R_RS02885	COG0460	homoserine dehydrogenase
BF638R_RS02890	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BF638R_RS02895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BF638R_RS02950	COG1629	transport
BF638R_RS02950	COG4206	TonB-dependent receptor
BF638R_RS02955	COG0702	epimerase
BF638R_RS02960	COG3250	beta-galactosidase activity
BF638R_RS02970	COG3507	Belongs to the glycosyl hydrolase 43 family
BF638R_RS02985	COG4771	TonB-dependent receptor
BF638R_RS03000	COG0628	permease
BF638R_RS03015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BF638R_RS03030	COG2095	MarC family integral membrane protein
BF638R_RS03040	COG1629	transport
BF638R_RS03050	COG1629	transport
BF638R_RS03050	COG4206	TonB-dependent receptor
BF638R_RS03055	COG4974	Belongs to the 'phage' integrase family
BF638R_RS03060	COG4771	TonB-dependent receptor
BF638R_RS03065	COG0702	epimerase
BF638R_RS03070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BF638R_RS03085	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BF638R_RS03085	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BF638R_RS03100	COG0531	amino acid
BF638R_RS03110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF638R_RS03115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF638R_RS03120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF638R_RS03155	COG1162	GTPase activity
BF638R_RS03160	COG0233	cytoplasmic translational termination
BF638R_RS03180	COG0443	Heat shock 70 kDa protein
BF638R_RS03195	COG0528	UMP kinase activity
BF638R_RS03200	COG0534	Mate efflux family protein
BF638R_RS03235	COG0792	nuclease activity
BF638R_RS03255	COG1183	phosphatidylcholine synthase activity
BF638R_RS03260	COG0688	phosphatidylethanolamine metabolic process
BF638R_RS03270	COG3118	belongs to the thioredoxin family
BF638R_RS03305	COG0714	Associated with various cellular activities
BF638R_RS03320	COG0802	atpase or kinase
BF638R_RS03325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BF638R_RS03335	COG2234	aminopeptidase activity
BF638R_RS03355	COG1629	transport
BF638R_RS03375	COG3250	beta-galactosidase activity
BF638R_RS03380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BF638R_RS03390	COG0784	Response regulator, receiver
BF638R_RS03390	COG2205	protein histidine kinase activity
BF638R_RS03415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BF638R_RS03430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF638R_RS03435	COG0742	ribosomal rna small subunit methyltransferase
BF638R_RS03460	COG4771	TonB-dependent receptor
BF638R_RS03470	COG3537	Alpha-1,2-mannosidase
BF638R_RS03485	COG3537	Alpha-1,2-mannosidase
BF638R_RS03490	COG2814	Major facilitator Superfamily
BF638R_RS03505	COG0739	heme binding
BF638R_RS03515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BF638R_RS03520	COG3942	CHAP domain
BF638R_RS03520	COG1388	LysM domain
BF638R_RS03530	COG1475	DNA binding
BF638R_RS03535	COG1192	Involved in chromosome partitioning
BF638R_RS03540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BF638R_RS03545	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF638R_RS03555	COG4589	Belongs to the CDS family
BF638R_RS03560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BF638R_RS03565	COG0799	negative regulation of ribosome biogenesis
BF638R_RS03580	COG2239	Acts as a magnesium transporter
BF638R_RS03585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BF638R_RS03595	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF638R_RS03665	COG0668	transmembrane transport
BF638R_RS03670	COG0662	Cupin 2, conserved barrel domain protein
BF638R_RS03670	COG2207	Transcriptional regulator
BF638R_RS03745	COG1215	transferase activity, transferring glycosyl groups
BF638R_RS03755	COG1442	glycosyl transferase family 8
BF638R_RS03755	COG1216	Glycosyl transferase, family 2
BF638R_RS03760	COG1086	Polysaccharide biosynthesis protein
BF638R_RS03765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF638R_RS03770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BF638R_RS03810	COG1215	transferase activity, transferring glycosyl groups
BF638R_RS03815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BF638R_RS03820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF638R_RS03830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF638R_RS03845	COG0667	Aldo Keto reductase
BF638R_RS03850	COG1472	Belongs to the glycosyl hydrolase 3 family
BF638R_RS03855	COG4771	TonB-dependent receptor
BF638R_RS03860	COG0702	epimerase
BF638R_RS03900	COG5012	cobalamin binding
BF638R_RS03915	COG4124	Belongs to the glycosyl hydrolase 26 family
BF638R_RS03920	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BF638R_RS03925	COG2211	Major facilitator Superfamily
BF638R_RS03930	COG2942	2-epimerase
BF638R_RS03970	COG2205	protein histidine kinase activity
BF638R_RS03970	COG5002	protein histidine kinase activity
BF638R_RS03970	COG0784	Response regulator, receiver
BF638R_RS03980	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF638R_RS03985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BF638R_RS03990	COG0713	ATP synthesis coupled electron transport
BF638R_RS03995	COG0839	Belongs to the complex I subunit 6 family
BF638R_RS04005	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BF638R_RS04010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF638R_RS04010	COG0649	NAD binding
BF638R_RS04015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF638R_RS04020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF638R_RS04030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF638R_RS04035	COG0569	domain protein
BF638R_RS04040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BF638R_RS04045	COG1073	alpha beta
BF638R_RS04055	COG0546	phosphoglycolate phosphatase activity
BF638R_RS04060	COG3119	arylsulfatase activity
BF638R_RS04075	COG3119	arylsulfatase activity
BF638R_RS04085	COG4771	TonB-dependent receptor
BF638R_RS04090	COG3292	Two component regulator propeller
BF638R_RS04090	COG0745	RESPONSE REGULATOR receiver
BF638R_RS04090	COG2205	protein histidine kinase activity
BF638R_RS04095	COG2271	Major facilitator Superfamily
BF638R_RS04120	COG0805	protein transport
BF638R_RS04125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BF638R_RS04130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BF638R_RS04150	COG4585	Histidine kinase
BF638R_RS04170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF638R_RS04175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BF638R_RS04175	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BF638R_RS04180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF638R_RS04185	COG1078	dGTPase activity
BF638R_RS04190	COG0284	orotidine-5'-phosphate decarboxylase activity
BF638R_RS04195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BF638R_RS04200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BF638R_RS04210	COG1704	LemA family
BF638R_RS04225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BF638R_RS04230	COG2226	methyltransferase
BF638R_RS04235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BF638R_RS04240	COG1702	phosphate starvation-inducible protein PhoH
BF638R_RS04250	COG2268	Band 7 protein
BF638R_RS04270	COG0101	tRNA pseudouridine synthase activity
BF638R_RS04290	COG3250	beta-galactosidase activity
BF638R_RS04295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF638R_RS04320	COG0457	Tetratricopeptide repeat
BF638R_RS04325	COG2814	Major facilitator Superfamily
BF638R_RS04355	COG1629	transport
BF638R_RS04355	COG4206	TonB-dependent receptor
BF638R_RS04365	COG4771	TonB-dependent receptor
BF638R_RS04375	COG1629	transport
BF638R_RS04375	COG4206	TonB-dependent receptor
BF638R_RS04390	COG4206	TonB-dependent receptor
BF638R_RS04390	COG1629	transport
BF638R_RS04395	COG0702	epimerase
BF638R_RS04400	COG0673	inositol 2-dehydrogenase activity
BF638R_RS04440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BF638R_RS04445	COG0793	Belongs to the peptidase S41A family
BF638R_RS04450	COG2131	deaminase
BF638R_RS04460	COG0339	signal peptide processing
BF638R_RS04470	COG1970	mechanosensitive ion channel activity
BF638R_RS04475	COG0519	Catalyzes the synthesis of GMP from XMP
BF638R_RS04475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BF638R_RS04490	COG1629	transport
BF638R_RS04490	COG4206	TonB-dependent receptor
BF638R_RS04500	COG4206	TonB-dependent receptor
BF638R_RS04500	COG1629	transport
BF638R_RS04505	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BF638R_RS04525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BF638R_RS04545	COG1242	4 iron, 4 sulfur cluster binding
BF638R_RS04555	COG0363	glucosamine-6-phosphate deaminase activity
BF638R_RS04565	COG0009	L-threonylcarbamoyladenylate synthase
BF638R_RS04575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BF638R_RS04580	COG0561	phosphatase activity
BF638R_RS04585	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BF638R_RS04590	COG2873	o-acetylhomoserine
BF638R_RS04645	COG0297	glycogen (starch) synthase activity
BF638R_RS04650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BF638R_RS04655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BF638R_RS04660	COG0543	2 iron, 2 sulfur cluster binding
BF638R_RS04670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BF638R_RS04675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BF638R_RS04680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BF638R_RS04685	COG0546	phosphoglycolate phosphatase activity
BF638R_RS04690	COG0791	NLP P60 protein
BF638R_RS04705	COG0612	Peptidase, M16
BF638R_RS04710	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BF638R_RS04715	COG1597	lipid kinase activity
BF638R_RS04720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BF638R_RS04730	COG1136	(ABC) transporter
BF638R_RS04750	COG2211	Major facilitator Superfamily
BF638R_RS04760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BF638R_RS04775	COG1674	ftsk spoiiie
BF638R_RS04785	COG0492	ferredoxin-NADP+ reductase activity
BF638R_RS04790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS04825	COG1595	DNA-templated transcription, initiation
BF638R_RS04840	COG3956	TIGRFAM MazG family protein
BF638R_RS04850	COG0525	valine-tRNA ligase activity
BF638R_RS04855	COG0784	Response regulator, receiver
BF638R_RS04855	COG2198	Histidine kinase
BF638R_RS04855	COG2205	protein histidine kinase activity
BF638R_RS04875	COG4771	TonB-dependent receptor
BF638R_RS04890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BF638R_RS04905	COG4206	TonB-dependent receptor
BF638R_RS04905	COG1629	transport
BF638R_RS04910	COG0702	epimerase
BF638R_RS04915	COG3119	arylsulfatase activity
BF638R_RS04920	COG3119	arylsulfatase activity
BF638R_RS04940	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
BF638R_RS04950	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BF638R_RS04970	COG1253	flavin adenine dinucleotide binding
BF638R_RS04980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BF638R_RS04990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BF638R_RS05030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BF638R_RS05040	COG2226	methyltransferase
BF638R_RS05080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BF638R_RS05125	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BF638R_RS05135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF638R_RS05145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF638R_RS05170	COG4771	TonB-dependent receptor
BF638R_RS05175	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BF638R_RS05180	COG0563	adenylate kinase activity
BF638R_RS05185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BF638R_RS05190	COG1496	oxidoreductase activity
BF638R_RS05210	COG2706	6-phosphogluconolactonase activity
BF638R_RS05245	COG1288	antiporter activity
BF638R_RS05265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BF638R_RS05290	COG0564	pseudouridine synthase activity
BF638R_RS05305	COG1501	Belongs to the glycosyl hydrolase 31 family
BF638R_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
BF638R_RS05350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BF638R_RS05365	COG3645	SOS response
BF638R_RS05390	COG0582	viral genome integration into host DNA
BF638R_RS05430	COG4974	Belongs to the 'phage' integrase family
BF638R_RS05455	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BF638R_RS05485	COG3645	SOS response
BF638R_RS05490	COG4974	Belongs to the 'phage' integrase family
BF638R_RS05525	COG1910	domain protein
BF638R_RS05550	COG4974	Belongs to the 'phage' integrase family
BF638R_RS05560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BF638R_RS05565	COG0784	Response regulator, receiver
BF638R_RS05565	COG5002	protein histidine kinase activity
BF638R_RS05570	COG2910	NAD(P)H-binding
BF638R_RS05575	COG2176	DNA-directed DNA polymerase activity
BF638R_RS05585	COG4864	UPF0365 protein
BF638R_RS05600	COG0037	tRNA processing
BF638R_RS05610	COG1477	protein flavinylation
BF638R_RS05615	COG1971	Probably functions as a manganese efflux pump
BF638R_RS05630	COG0463	Glycosyl transferase, family 2
BF638R_RS05645	COG0148	phosphopyruvate hydratase activity
BF638R_RS05655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BF638R_RS05660	COG1082	Xylose isomerase domain protein TIM barrel
BF638R_RS05680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BF638R_RS05685	COG0193	aminoacyl-tRNA hydrolase activity
BF638R_RS05690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BF638R_RS05700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BF638R_RS05705	COG1862	Preprotein translocase
BF638R_RS05715	COG0237	dephospho-CoA kinase activity
BF638R_RS05730	COG1401	restriction endodeoxyribonuclease activity
BF638R_RS05750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BF638R_RS05815	COG0542	response to heat
BF638R_RS05825	COG0583	DNA-binding transcription factor activity
BF638R_RS05830	COG2855	membrane
BF638R_RS05845	COG1595	DNA-templated transcription, initiation
BF638R_RS05860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BF638R_RS05880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF638R_RS05900	COG0443	Heat shock 70 kDa protein
BF638R_RS05910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BF638R_RS05915	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BF638R_RS05920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF638R_RS05935	COG1501	Belongs to the glycosyl hydrolase 31 family
BF638R_RS05960	COG1629	transport
BF638R_RS05960	COG4206	TonB-dependent receptor
BF638R_RS05970	COG1408	metallophosphoesterase
BF638R_RS05975	COG1368	sulfuric ester hydrolase activity
BF638R_RS05985	COG3634	alkyl hydroperoxide reductase activity
BF638R_RS06020	COG1760	l-serine dehydratase
BF638R_RS06025	COG0598	Magnesium transport protein CorA
BF638R_RS06030	COG1193	negative regulation of DNA recombination
BF638R_RS06055	COG1063	alcohol dehydrogenase
BF638R_RS06070	COG3119	arylsulfatase activity
BF638R_RS06075	COG5002	protein histidine kinase activity
BF638R_RS06075	COG0784	Response regulator, receiver
BF638R_RS06080	COG2855	membrane
BF638R_RS06085	COG2217	Heavy metal translocating P-type atpase
BF638R_RS06095	COG2885	chlorophyll binding
BF638R_RS06100	COG3189	MarR family transcriptional regulator
BF638R_RS06105	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BF638R_RS06110	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF638R_RS06115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BF638R_RS06135	COG4651	solute:proton antiporter activity
BF638R_RS06135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BF638R_RS06140	COG1280	lysine exporter protein (LysE YggA)
BF638R_RS06155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BF638R_RS06160	COG0561	phosphatase activity
BF638R_RS06165	COG1169	isochorismate synthase
BF638R_RS06170	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BF638R_RS06185	COG4948	Mandelate Racemase Muconate Lactonizing
BF638R_RS06200	COG1082	Xylose isomerase domain protein TIM barrel
BF638R_RS06215	COG4771	TonB-dependent receptor
BF638R_RS06245	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BF638R_RS06250	COG0783	Belongs to the Dps family
BF638R_RS06255	COG0583	DNA-binding transcription factor activity
BF638R_RS06275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BF638R_RS06290	COG4974	Belongs to the 'phage' integrase family
BF638R_RS06315	COG0210	DNA helicase
BF638R_RS06435	COG0551	DNA topoisomerase type I activity
BF638R_RS06435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF638R_RS06510	COG4974	Belongs to the 'phage' integrase family
BF638R_RS06515	COG1309	transcriptional regulator
BF638R_RS06545	COG1253	flavin adenine dinucleotide binding
BF638R_RS06550	COG0501	Belongs to the peptidase M48B family
BF638R_RS06575	COG2873	o-acetylhomoserine
BF638R_RS06580	COG0482	sulfurtransferase activity
BF638R_RS06585	COG2197	response regulator
BF638R_RS06595	COG1757	Na H antiporter
BF638R_RS06610	COG2814	Major facilitator Superfamily
BF638R_RS06615	COG4953	penicillin-binding protein 1C
BF638R_RS06620	COG2373	Large extracellular alpha-helical protein
BF638R_RS06630	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BF638R_RS06630	COG1918	ferrous iron import across plasma membrane
BF638R_RS06685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BF638R_RS06730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BF638R_RS06735	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BF638R_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
BF638R_RS06795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF638R_RS06800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF638R_RS06805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF638R_RS06815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF638R_RS06820	COG0490	domain, Protein
BF638R_RS06820	COG0471	metal ion transport
BF638R_RS06835	COG0346	lactoylglutathione lyase activity
BF638R_RS06850	COG0259	pyridoxamine-phosphate oxidase activity
BF638R_RS06855	COG1741	Belongs to the pirin family
BF638R_RS06875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BF638R_RS06905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BF638R_RS06915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BF638R_RS06930	COG1595	DNA-templated transcription, initiation
BF638R_RS06955	COG0686	Belongs to the AlaDH PNT family
BF638R_RS06970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BF638R_RS06985	COG1629	transport
BF638R_RS07000	COG3345	alpha-galactosidase
BF638R_RS07015	COG0488	(ABC) transporter
BF638R_RS07020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BF638R_RS07025	COG3059	membrane
BF638R_RS07030	COG1917	Cupin 2, conserved barrel domain protein
BF638R_RS07030	COG2207	Transcriptional regulator
BF638R_RS07035	COG0295	cytidine deaminase activity
BF638R_RS07040	COG1388	LysM domain
BF638R_RS07040	COG1705	Flagellar rod assembly protein muramidase FlgJ
BF638R_RS07050	COG0577	efflux transmembrane transporter activity
BF638R_RS07055	COG0577	efflux transmembrane transporter activity
BF638R_RS07060	COG0577	efflux transmembrane transporter activity
BF638R_RS07070	COG1136	(ABC) transporter
BF638R_RS07070	COG0577	efflux transmembrane transporter activity
BF638R_RS07085	COG1136	(ABC) transporter
BF638R_RS07100	COG1136	(ABC) transporter
BF638R_RS07120	COG0784	Response regulator, receiver
BF638R_RS07120	COG2205	protein histidine kinase activity
BF638R_RS07130	COG2204	response regulator
BF638R_RS07185	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BF638R_RS07215	COG2244	polysaccharide biosynthetic process
BF638R_RS07230	COG4641	Protein conserved in bacteria
BF638R_RS07230	COG0438	transferase activity, transferring glycosyl groups
BF638R_RS07260	COG1028	Short-chain dehydrogenase reductase Sdr
BF638R_RS07265	COG3475	LICD family
BF638R_RS07275	COG0438	transferase activity, transferring glycosyl groups
BF638R_RS07290	COG0438	transferase activity, transferring glycosyl groups
BF638R_RS07295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF638R_RS07300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF638R_RS07305	COG1530	ribonuclease E activity
BF638R_RS07320	COG3119	arylsulfatase activity
BF638R_RS07325	COG0629	single-stranded DNA binding
BF638R_RS07385	COG4206	TonB-dependent receptor
BF638R_RS07400	COG5002	protein histidine kinase activity
BF638R_RS07405	COG0745	RESPONSE REGULATOR receiver
BF638R_RS07430	COG0488	(ABC) transporter
BF638R_RS07445	COG5492	domain, Protein
BF638R_RS07455	COG0436	Aminotransferase
BF638R_RS07460	COG4591	ABC-type transport system involved in lipoprotein release permease component
BF638R_RS07465	COG1215	transferase activity, transferring glycosyl groups
BF638R_RS07470	COG0628	permease
BF638R_RS07475	COG3852	Histidine kinase
BF638R_RS07490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF638R_RS07495	COG1136	(ABC) transporter
BF638R_RS07495	COG0577	efflux transmembrane transporter activity
BF638R_RS07500	COG0577	efflux transmembrane transporter activity
BF638R_RS07505	COG1252	NADH dehydrogenase
BF638R_RS07535	COG4771	TonB-dependent receptor
BF638R_RS07545	COG1620	l-lactate permease
BF638R_RS07550	COG2885	chlorophyll binding
BF638R_RS07550	COG3047	cAMP biosynthetic process
BF638R_RS07560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BF638R_RS07565	COG0439	Biotin carboxylase
BF638R_RS07570	COG0511	ligase activity, forming carbon-carbon bonds
BF638R_RS07575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BF638R_RS07610	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF638R_RS07615	COG0022	dehydrogenase e1 component
BF638R_RS07620	COG0716	FMN binding
BF638R_RS07625	COG2264	protein methyltransferase activity
BF638R_RS07665	COG0590	tRNA wobble adenosine to inosine editing
BF638R_RS07690	COG0673	inositol 2-dehydrogenase activity
BF638R_RS07695	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BF638R_RS07730	COG0698	ribose 5-phosphate isomerase
BF638R_RS07735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BF638R_RS07740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BF638R_RS07755	COG1482	cell wall glycoprotein biosynthetic process
BF638R_RS07775	COG0513	Belongs to the DEAD box helicase family
BF638R_RS07780	COG4221	oxidoreductase activity
BF638R_RS07795	COG3250	beta-galactosidase activity
BF638R_RS07805	COG3273	potassium ion transport
BF638R_RS07805	COG0471	metal ion transport
BF638R_RS07810	COG0529	Catalyzes the synthesis of activated sulfate
BF638R_RS07815	COG0175	sulfate reduction
BF638R_RS07820	COG2895	sulfate adenylyltransferase (ATP) activity
BF638R_RS07860	COG4974	Belongs to the 'phage' integrase family
BF638R_RS07885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BF638R_RS07890	COG0242	peptide deformylase activity
BF638R_RS07905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BF638R_RS07910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BF638R_RS07915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BF638R_RS07920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BF638R_RS07930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BF638R_RS07935	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BF638R_RS07950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BF638R_RS07995	COG1940	carbohydrate kinase activity
BF638R_RS08000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BF638R_RS08010	COG2271	Major facilitator Superfamily
BF638R_RS08015	COG2731	YhcH YjgK YiaL family protein
BF638R_RS08020	COG1629	transport
BF638R_RS08020	COG4206	TonB-dependent receptor
BF638R_RS08025	COG0702	epimerase
BF638R_RS08030	COG0702	epimerase
BF638R_RS08035	COG4771	TonB-dependent receptor
BF638R_RS08040	COG0702	epimerase
BF638R_RS08045	COG4771	TonB-dependent receptor
BF638R_RS08050	COG4206	TonB-dependent receptor
BF638R_RS08050	COG1629	transport
BF638R_RS08065	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS08085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS08095	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS08100	COG3537	Alpha-1,2-mannosidase
BF638R_RS08105	COG3250	beta-galactosidase activity
BF638R_RS08115	COG0702	epimerase
BF638R_RS08120	COG0484	heat shock protein binding
BF638R_RS08125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BF638R_RS08130	COG0488	(ABC) transporter
BF638R_RS08135	COG1595	DNA-templated transcription, initiation
BF638R_RS08160	COG0823	Involved in the tonB-independent uptake of proteins
BF638R_RS08170	COG1629	transport
BF638R_RS08170	COG4206	TonB-dependent receptor
BF638R_RS08180	COG3537	Alpha-1,2-mannosidase
BF638R_RS08185	COG3568	Endonuclease Exonuclease Phosphatase
BF638R_RS08190	COG1785	Belongs to the alkaline phosphatase family
BF638R_RS08210	COG2207	Transcriptional regulator
BF638R_RS08210	COG1609	Transcriptional regulator
BF638R_RS08215	COG2183	response to ionizing radiation
BF638R_RS08395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF638R_RS08400	COG1120	ATPase activity
BF638R_RS08420	COG1192	Involved in chromosome partitioning
BF638R_RS08425	COG1629	transport
BF638R_RS08480	COG4974	Belongs to the 'phage' integrase family
BF638R_RS08485	COG4974	Belongs to the 'phage' integrase family
BF638R_RS08495	COG2885	chlorophyll binding
BF638R_RS08610	COG2183	response to ionizing radiation
BF638R_RS08620	COG0737	Belongs to the 5'-nucleotidase family
BF638R_RS08625	COG1956	GAF domain-containing protein
BF638R_RS08635	COG4771	TonB-dependent receptor
BF638R_RS08660	COG0534	Mate efflux family protein
BF638R_RS08670	COG0534	Mate efflux family protein
BF638R_RS08680	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BF638R_RS08690	COG0318	PFAM AMP-dependent synthetase and ligase
BF638R_RS08695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF638R_RS08700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BF638R_RS08735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BF638R_RS08745	COG4750	Nucleotidyl transferase
BF638R_RS08760	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BF638R_RS08805	COG1086	Polysaccharide biosynthesis protein
BF638R_RS08815	COG1091	dTDP-4-dehydrorhamnose reductase activity
BF638R_RS08825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF638R_RS08830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF638R_RS08850	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BF638R_RS08855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BF638R_RS08860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BF638R_RS08865	COG0363	glucosamine-6-phosphate deaminase activity
BF638R_RS08885	COG4413	Urea transporter
BF638R_RS08925	COG3279	Response regulator of the LytR AlgR family
BF638R_RS08935	COG1136	(ABC) transporter
BF638R_RS08935	COG0577	efflux transmembrane transporter activity
BF638R_RS08940	COG1136	(ABC) transporter
BF638R_RS08945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF638R_RS08970	COG3831	ATPase activity
BF638R_RS08970	COG4884	unkown
BF638R_RS08985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF638R_RS08995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BF638R_RS09000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BF638R_RS09005	COG3250	beta-galactosidase activity
BF638R_RS09030	COG0501	Belongs to the peptidase M48B family
BF638R_RS09035	COG1704	LemA family
BF638R_RS09040	COG1595	DNA-templated transcription, initiation
BF638R_RS09055	COG1629	transport
BF638R_RS09055	COG4206	TonB-dependent receptor
BF638R_RS09065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF638R_RS09070	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BF638R_RS09070	COG2885	chlorophyll binding
BF638R_RS09080	COG0697	spore germination
BF638R_RS09150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF638R_RS09165	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BF638R_RS09170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF638R_RS09175	COG2814	Major facilitator Superfamily
BF638R_RS09180	COG4771	TonB-dependent receptor
BF638R_RS09205	COG4771	TonB-dependent receptor
BF638R_RS09355	COG0542	response to heat
BF638R_RS09380	COG0156	8-amino-7-oxononanoate synthase activity
BF638R_RS09405	COG4974	Belongs to the 'phage' integrase family
BF638R_RS09525	COG1335	isochorismatase
BF638R_RS09585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BF638R_RS09705	COG0551	DNA topoisomerase type I activity
BF638R_RS09705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF638R_RS09790	COG1475	DNA binding
BF638R_RS09955	COG4974	Belongs to the 'phage' integrase family
BF638R_RS09965	COG0488	(ABC) transporter
BF638R_RS09985	COG2205	protein histidine kinase activity
BF638R_RS09985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF638R_RS09985	COG0784	Response regulator, receiver
BF638R_RS09985	COG2198	Histidine kinase
BF638R_RS10005	COG0438	transferase activity, transferring glycosyl groups
BF638R_RS10010	COG2244	polysaccharide biosynthetic process
BF638R_RS10015	COG1216	Glycosyl transferase, family 2
BF638R_RS10015	COG1442	glycosyl transferase family 8
BF638R_RS10035	COG1215	transferase activity, transferring glycosyl groups
BF638R_RS10065	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BF638R_RS10070	COG1805	sodium ion transport
BF638R_RS10075	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BF638R_RS10100	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BF638R_RS10105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BF638R_RS10115	COG0545	Peptidyl-prolyl cis-trans isomerase
BF638R_RS10120	COG1739	Uncharacterized protein family UPF0029
BF638R_RS10130	COG0778	Nitroreductase
BF638R_RS10135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BF638R_RS10135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BF638R_RS10140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF638R_RS10170	COG2217	Heavy metal translocating P-type atpase
BF638R_RS10210	COG3852	Histidine kinase
BF638R_RS10215	COG2204	response regulator
BF638R_RS10235	COG1136	(ABC) transporter
BF638R_RS10235	COG0577	efflux transmembrane transporter activity
BF638R_RS10250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF638R_RS10255	COG1755	Isoprenylcysteine carboxyl methyltransferase
BF638R_RS10265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BF638R_RS10280	COG1678	Uncharacterized ACR, COG1678
BF638R_RS10295	COG0667	Aldo Keto reductase
BF638R_RS10305	COG0656	L-ascorbic acid biosynthetic process
BF638R_RS10315	COG0656	L-ascorbic acid biosynthetic process
BF638R_RS10320	COG0656	L-ascorbic acid biosynthetic process
BF638R_RS10330	COG0534	Mate efflux family protein
BF638R_RS10335	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BF638R_RS10350	COG1028	Short-chain dehydrogenase reductase Sdr
BF638R_RS10370	COG1979	alcohol dehydrogenase
BF638R_RS10390	COG1028	Short-chain dehydrogenase reductase Sdr
BF638R_RS10395	COG0667	Aldo Keto reductase
BF638R_RS10410	COG2311	Membrane
BF638R_RS10415	COG0667	Aldo Keto reductase
BF638R_RS10475	COG4771	TonB-dependent receptor
BF638R_RS10500	COG1309	transcriptional regulator
BF638R_RS10515	COG1132	(ABC) transporter
BF638R_RS10520	COG3850	Histidine kinase
BF638R_RS10520	COG2205	protein histidine kinase activity
BF638R_RS10520	COG3437	response regulator, receiver
BF638R_RS10520	COG4999	Histidine kinase
BF638R_RS10535	COG1522	sequence-specific DNA binding
BF638R_RS10555	COG3969	phosphoadenosine phosphosulfate
BF638R_RS10560	COG1475	DNA binding
BF638R_RS10600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF638R_RS10605	COG0745	RESPONSE REGULATOR receiver
BF638R_RS10620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS10630	COG1629	transport
BF638R_RS10630	COG4206	TonB-dependent receptor
BF638R_RS10640	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BF638R_RS10660	COG1022	Amp-dependent synthetase and ligase
BF638R_RS10665	COG3263	regulation of cellular component size
BF638R_RS10710	COG0577	efflux transmembrane transporter activity
BF638R_RS10710	COG1136	(ABC) transporter
BF638R_RS10720	COG1136	(ABC) transporter
BF638R_RS10720	COG0577	efflux transmembrane transporter activity
BF638R_RS10735	COG0534	Mate efflux family protein
BF638R_RS10740	COG1011	Hydrolase
BF638R_RS10745	COG0167	dihydroorotate dehydrogenase activity
BF638R_RS10755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BF638R_RS10770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BF638R_RS10785	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BF638R_RS10795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BF638R_RS10805	COG0356	it plays a direct role in the translocation of protons across the membrane
BF638R_RS10810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BF638R_RS10815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BF638R_RS10820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BF638R_RS10825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BF638R_RS10830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BF638R_RS10835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BF638R_RS10840	COG3118	belongs to the thioredoxin family
BF638R_RS10860	COG0745	RESPONSE REGULATOR receiver
BF638R_RS10865	COG5002	protein histidine kinase activity
BF638R_RS10895	COG1120	ATPase activity
BF638R_RS10900	COG1091	dTDP-4-dehydrorhamnose reductase activity
BF638R_RS10930	COG2205	protein histidine kinase activity
BF638R_RS10935	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BF638R_RS10945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BF638R_RS10960	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BF638R_RS10965	COG0540	Belongs to the ATCase OTCase family
BF638R_RS10975	COG2431	L-lysine efflux transmembrane transporter activity
BF638R_RS11000	COG2837	iron assimilation
BF638R_RS11010	COG1629	transport
BF638R_RS11010	COG4206	TonB-dependent receptor
BF638R_RS11030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BF638R_RS11040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BF638R_RS11060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BF638R_RS11065	COG2205	protein histidine kinase activity
BF638R_RS11095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BF638R_RS11100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF638R_RS11110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BF638R_RS11120	COG0673	inositol 2-dehydrogenase activity
BF638R_RS11130	COG2223	nitrite transmembrane transporter activity
BF638R_RS11150	COG0671	phosphoesterase, PA-phosphatase related
BF638R_RS11160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BF638R_RS11165	COG0045	succinate-CoA ligase (ADP-forming) activity
BF638R_RS11170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BF638R_RS11175	COG0351	phosphomethylpyrimidine kinase
BF638R_RS11185	COG1070	Carbohydrate kinase
BF638R_RS11195	COG2814	Major facilitator Superfamily
BF638R_RS11195	COG0477	Major facilitator Superfamily
BF638R_RS11205	COG3153	acetyltransferase
BF638R_RS11205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BF638R_RS11210	COG0450	alkyl hydroperoxide reductase
BF638R_RS11215	COG0724	RNA recognition motif
BF638R_RS11220	COG1858	cytochrome C peroxidase
BF638R_RS11225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BF638R_RS11245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BF638R_RS11255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BF638R_RS11270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BF638R_RS11320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BF638R_RS11330	COG1904	glucuronate isomerase
BF638R_RS11360	COG0513	Belongs to the DEAD box helicase family
BF638R_RS11365	COG3830	Belongs to the UPF0237 family
BF638R_RS11365	COG0560	Phosphoserine phosphatase
BF638R_RS11380	COG0343	queuine tRNA-ribosyltransferase activity
BF638R_RS11385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BF638R_RS11390	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BF638R_RS11415	COG2205	protein histidine kinase activity
BF638R_RS11420	COG2204	response regulator
BF638R_RS11465	COG0577	efflux transmembrane transporter activity
BF638R_RS11465	COG1136	(ABC) transporter
BF638R_RS11475	COG0156	8-amino-7-oxononanoate synthase activity
BF638R_RS11480	COG1597	lipid kinase activity
BF638R_RS11485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BF638R_RS11510	COG1136	(ABC) transporter
BF638R_RS11510	COG0577	efflux transmembrane transporter activity
BF638R_RS11535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BF638R_RS11565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BF638R_RS11580	COG0543	2 iron, 2 sulfur cluster binding
BF638R_RS11585	COG0167	dihydroorotate dehydrogenase activity
BF638R_RS11590	COG0336	Belongs to the RNA methyltransferase TrmD family
BF638R_RS11600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BF638R_RS11610	COG2315	Protein conserved in bacteria
BF638R_RS11645	COG0542	response to heat
BF638R_RS11690	COG2304	oxidoreductase activity
BF638R_RS11705	COG0714	Associated with various cellular activities
BF638R_RS11710	COG1652	LysM domain
BF638R_RS11720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BF638R_RS11725	COG0552	protein localization to endoplasmic reticulum
BF638R_RS11730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BF638R_RS11735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BF638R_RS11745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BF638R_RS11760	COG0442	prolyl-tRNA aminoacylation
BF638R_RS11770	COG4946	Tricorn protease homolog
BF638R_RS11770	COG0793	Belongs to the peptidase S41A family
BF638R_RS11780	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
BF638R_RS11785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BF638R_RS11790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BF638R_RS11800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BF638R_RS11810	COG1492	cobalamin metabolic process
BF638R_RS11825	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BF638R_RS11855	COG2096	Adenosyltransferase
BF638R_RS11860	COG1797	cobyrinic acid a,c-diamide synthase activity
BF638R_RS11875	COG2966	Psort location CytoplasmicMembrane, score
BF638R_RS11885	COG4771	TonB-dependent receptor
BF638R_RS11895	COG4774	siderophore transport
BF638R_RS11905	COG1429	ligase activity, forming nitrogen-metal bonds
BF638R_RS11940	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BF638R_RS12080	COG0305	Participates in initiation and elongation during chromosome replication
BF638R_RS12095	COG3023	N-Acetylmuramoyl-L-alanine amidase
BF638R_RS12160	COG0352	thiamine-phosphate diphosphorylase activity
BF638R_RS12165	COG2022	thiamine diphosphate biosynthetic process
BF638R_RS12170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BF638R_RS12190	COG0352	thiamine-phosphate diphosphorylase activity
BF638R_RS12250	COG0574	Belongs to the PEP-utilizing enzyme family
BF638R_RS12250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BF638R_RS12255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BF638R_RS12260	COG0564	pseudouridine synthase activity
BF638R_RS12275	COG0024	Methionine aminopeptidase
BF638R_RS12300	COG0481	GTPase activity
BF638R_RS12320	COG0708	Exodeoxyribonuclease III
BF638R_RS12325	COG1914	H( )-stimulated, divalent metal cation uptake system
BF638R_RS12340	COG0217	transcriptional regulatory protein
BF638R_RS12350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF638R_RS12355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF638R_RS12375	COG0438	transferase activity, transferring glycosyl groups
BF638R_RS12390	COG1215	transferase activity, transferring glycosyl groups
BF638R_RS12395	COG0028	Belongs to the TPP enzyme family
BF638R_RS12400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF638R_RS12410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BF638R_RS12440	COG0305	Participates in initiation and elongation during chromosome replication
BF638R_RS12445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BF638R_RS12460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BF638R_RS12465	COG4657	Part of a membrane complex involved in electron transport
BF638R_RS12470	COG4660	Part of a membrane complex involved in electron transport
BF638R_RS12475	COG4659	FMN binding
BF638R_RS12480	COG4658	electron transport chain
BF638R_RS12485	COG4656	Part of a membrane complex involved in electron transport
BF638R_RS12510	COG0504	CTP synthase activity
BF638R_RS12520	COG0534	Mate efflux family protein
BF638R_RS12525	COG1506	peptidase
BF638R_RS12525	COG0823	Involved in the tonB-independent uptake of proteins
BF638R_RS12540	COG1695	Transcriptional regulator
BF638R_RS12555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BF638R_RS12565	COG1388	LysM domain
BF638R_RS12565	COG3942	CHAP domain
BF638R_RS12595	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BF638R_RS12600	COG0556	nucleotide-excision repair
BF638R_RS12605	COG2949	membrane
BF638R_RS12615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BF638R_RS12625	COG4999	Histidine kinase
BF638R_RS12625	COG3850	Histidine kinase
BF638R_RS12625	COG3437	response regulator, receiver
BF638R_RS12625	COG2205	protein histidine kinase activity
BF638R_RS12635	COG0842	Transport permease protein
BF638R_RS12640	COG1131	(ABC) transporter
BF638R_RS12670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BF638R_RS12675	COG0505	Belongs to the CarA family
BF638R_RS12685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BF638R_RS12690	COG0367	asparagine synthase
BF638R_RS12705	COG3328	transposase activity
BF638R_RS12765	COG0436	Aminotransferase
BF638R_RS12775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BF638R_RS12785	COG1979	alcohol dehydrogenase
BF638R_RS12795	COG0133	tryptophan synthase activity
BF638R_RS12800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BF638R_RS12805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BF638R_RS12805	COG0512	Glutamine amidotransferase of anthranilate synthase
BF638R_RS12815	COG0134	indole-3-glycerol-phosphate synthase activity
BF638R_RS12820	COG0135	phosphoribosylanthranilate isomerase activity
BF638R_RS12825	COG0159	tryptophan synthase activity
BF638R_RS12830	COG0252	asparaginase activity
BF638R_RS12845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF638R_RS12855	COG0110	maltose O-acetyltransferase activity
BF638R_RS12860	COG2197	response regulator
BF638R_RS12870	COG0138	bifunctional purine biosynthesis protein purh
BF638R_RS12875	COG0716	FMN binding
BF638R_RS12900	COG1858	cytochrome C peroxidase
BF638R_RS12910	COG4771	TonB-dependent receptor
BF638R_RS12920	COG2814	Major facilitator Superfamily
BF638R_RS12925	COG1566	PFAM secretion protein HlyD family protein
BF638R_RS12960	COG4771	TonB-dependent receptor
BF638R_RS12985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF638R_RS12990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF638R_RS13000	COG2966	Psort location CytoplasmicMembrane, score
BF638R_RS13005	COG3610	response to peptide
BF638R_RS13020	COG1609	Transcriptional regulator
BF638R_RS13030	COG1733	regulation of RNA biosynthetic process
BF638R_RS13035	COG2198	Histidine kinase
BF638R_RS13035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF638R_RS13035	COG2205	protein histidine kinase activity
BF638R_RS13035	COG0784	Response regulator, receiver
BF638R_RS13055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BF638R_RS13060	COG1690	Belongs to the RtcB family
BF638R_RS13080	COG0228	four-way junction DNA binding
BF638R_RS13095	COG0724	RNA recognition motif
BF638R_RS13105	COG1177	transmembrane transport
BF638R_RS13110	COG1176	ABC-type spermidine putrescine transport system, permease component I
BF638R_RS13120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF638R_RS13130	COG0058	SHG alpha-glucan phosphorylase activity
BF638R_RS13140	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BF638R_RS13160	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BF638R_RS13215	COG0745	RESPONSE REGULATOR receiver
BF638R_RS13220	COG5002	protein histidine kinase activity
BF638R_RS13245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BF638R_RS13255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF638R_RS13265	COG4948	Mandelate Racemase Muconate Lactonizing
BF638R_RS13275	COG1295	ribonuclease BN
BF638R_RS13280	COG0778	Nitroreductase
BF638R_RS13290	COG0704	Plays a role in the regulation of phosphate uptake
BF638R_RS13295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BF638R_RS13300	COG0581	inorganic phosphate transmembrane transporter activity
BF638R_RS13305	COG0573	inorganic phosphate transmembrane transporter activity
BF638R_RS13315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BF638R_RS13335	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BF638R_RS13370	COG3023	N-Acetylmuramoyl-L-alanine amidase
BF638R_RS13410	COG0463	Glycosyl transferase, family 2
BF638R_RS13410	COG1216	Glycosyl transferase, family 2
BF638R_RS13455	COG0438	transferase activity, transferring glycosyl groups
BF638R_RS13470	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BF638R_RS13520	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BF638R_RS13550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BF638R_RS13555	COG0167	dihydroorotate dehydrogenase activity
BF638R_RS13620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF638R_RS13620	COG4191	Histidine kinase
BF638R_RS13635	COG2172	sigma factor antagonist activity
BF638R_RS13645	COG2208	phosphoserine phosphatase activity
BF638R_RS13670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BF638R_RS13690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BF638R_RS13695	COG0497	DNA recombination
BF638R_RS13705	COG5002	protein histidine kinase activity
BF638R_RS13705	COG2176	DNA-directed DNA polymerase activity
BF638R_RS13710	COG0592	DNA-directed DNA polymerase activity
BF638R_RS13725	COG0321	lipoyl(octanoyl) transferase activity
BF638R_RS13725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BF638R_RS13740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF638R_RS13745	COG0156	8-amino-7-oxononanoate synthase activity
BF638R_RS13830	COG0019	diaminopimelate decarboxylase activity
BF638R_RS13835	COG0527	aspartate kinase activity
BF638R_RS13840	COG2884	Cell division ATP-binding protein ftsE
BF638R_RS13845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BF638R_RS13845	COG0140	phosphoribosyl-ATP diphosphatase activity
BF638R_RS13855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BF638R_RS13875	COG3586	endonuclease activity
BF638R_RS13915	COG1472	Belongs to the glycosyl hydrolase 3 family
BF638R_RS13920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BF638R_RS13930	COG5012	cobalamin binding
BF638R_RS13940	COG1472	Belongs to the glycosyl hydrolase 3 family
BF638R_RS13945	COG0702	epimerase
BF638R_RS13950	COG4771	TonB-dependent receptor
BF638R_RS13965	COG0693	protein deglycase activity
BF638R_RS13970	COG0494	nUDIX hydrolase
BF638R_RS13980	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BF638R_RS14025	COG4977	sequence-specific DNA binding
BF638R_RS14025	COG1917	Cupin 2, conserved barrel domain protein
BF638R_RS14030	COG2814	Major facilitator Superfamily
BF638R_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
BF638R_RS14040	COG2207	Transcriptional regulator
BF638R_RS14055	COG1090	epimerase
BF638R_RS14085	COG0561	phosphatase activity
BF638R_RS14090	COG4206	TonB-dependent receptor
BF638R_RS14090	COG1629	transport
BF638R_RS14140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BF638R_RS14150	COG0363	glucosamine-6-phosphate deaminase activity
BF638R_RS14195	COG1032	radical SAM domain protein
BF638R_RS14200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BF638R_RS14205	COG0463	Glycosyl transferase, family 2
BF638R_RS14210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BF638R_RS14220	COG1410	methionine synthase
BF638R_RS14220	COG0646	methionine synthase
BF638R_RS14275	COG1408	metallophosphoesterase
BF638R_RS14280	COG1132	(ABC) transporter
BF638R_RS14285	COG1132	(ABC) transporter
BF638R_RS14300	COG0420	3'-5' exonuclease activity
BF638R_RS14320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF638R_RS14325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF638R_RS14335	COG0681	Belongs to the peptidase S26 family
BF638R_RS14410	COG0641	radical SAM
BF638R_RS14415	COG3591	Belongs to the peptidase S1B family
BF638R_RS14420	COG3591	Belongs to the peptidase S1B family
BF638R_RS14455	COG1773	rubredoxin
BF638R_RS14455	COG1592	Rubrerythrin
BF638R_RS14465	COG3152	Membrane
BF638R_RS14470	COG0339	signal peptide processing
BF638R_RS14475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BF638R_RS14475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BF638R_RS14485	COG4206	TonB-dependent receptor
BF638R_RS14485	COG1629	transport
BF638R_RS14500	COG0131	Imidazoleglycerol-phosphate dehydratase
BF638R_RS14500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BF638R_RS14510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BF638R_RS14515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BF638R_RS14525	COG1741	Belongs to the pirin family
BF638R_RS14530	COG4232	protein-disulfide reductase activity
BF638R_RS14540	COG0572	uridine kinase
BF638R_RS14550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF638R_RS14560	COG1410	methionine synthase
BF638R_RS14560	COG0646	methionine synthase
BF638R_RS14565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BF638R_RS14655	COG4499	WXG100 protein secretion system (Wss), protein YukC
BF638R_RS14655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF638R_RS14670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF638R_RS14680	COG1295	ribonuclease BN
BF638R_RS14705	COG2205	protein histidine kinase activity
BF638R_RS14705	COG2202	Pas domain
BF638R_RS14710	COG0534	Mate efflux family protein
BF638R_RS14715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BF638R_RS14720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF638R_RS14725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BF638R_RS14730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF638R_RS14790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BF638R_RS14830	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF638R_RS14840	COG0668	transmembrane transport
BF638R_RS14855	COG3250	beta-galactosidase activity
BF638R_RS14860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS14865	COG3119	arylsulfatase activity
BF638R_RS14870	COG3119	arylsulfatase activity
BF638R_RS14875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS14880	COG3292	Two component regulator propeller
BF638R_RS14880	COG2205	protein histidine kinase activity
BF638R_RS14880	COG0745	RESPONSE REGULATOR receiver
BF638R_RS14885	COG1830	Aldolase
BF638R_RS14890	COG0588	phosphoglycerate mutase activity
BF638R_RS14900	COG1119	ATPase activity
BF638R_RS14905	COG3119	arylsulfatase activity
BF638R_RS14910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS14920	COG4206	TonB-dependent receptor
BF638R_RS14920	COG1629	transport
BF638R_RS14930	COG1595	DNA-templated transcription, initiation
BF638R_RS14935	COG1523	belongs to the glycosyl hydrolase 13 family
BF638R_RS14940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BF638R_RS14960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BF638R_RS14970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BF638R_RS14975	COG0126	phosphoglycerate kinase activity
BF638R_RS14990	COG2311	Membrane
BF638R_RS15035	COG0424	maF-like protein
BF638R_RS15040	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BF638R_RS15055	COG0778	Nitroreductase
BF638R_RS15060	COG0288	reversible hydration of carbon dioxide
BF638R_RS15075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BF638R_RS15085	COG0511	ligase activity, forming carbon-carbon bonds
BF638R_RS15085	COG5016	pyruvate
BF638R_RS15090	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BF638R_RS15105	COG0366	Alpha amylase catalytic
BF638R_RS15125	COG0191	fructose-bisphosphate aldolase activity
BF638R_RS15135	COG0254	rRNA binding
BF638R_RS15160	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BF638R_RS15165	COG4206	TonB-dependent receptor
BF638R_RS15165	COG1629	transport
BF638R_RS15170	COG1609	Transcriptional regulator
BF638R_RS15180	COG1554	hydrolase, family 65, central catalytic
BF638R_RS15185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF638R_RS15205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BF638R_RS15205	COG0047	phosphoribosylformylglycinamidine synthase activity
BF638R_RS15210	COG0745	RESPONSE REGULATOR receiver
BF638R_RS15210	COG3292	Two component regulator propeller
BF638R_RS15210	COG2205	protein histidine kinase activity
BF638R_RS15225	COG1649	PFAM Uncharacterised BCR, COG1649
BF638R_RS15245	COG1966	Carbon starvation protein
BF638R_RS15250	COG1649	PFAM Uncharacterised BCR, COG1649
BF638R_RS15255	COG0784	Response regulator, receiver
BF638R_RS15255	COG2205	protein histidine kinase activity
BF638R_RS15295	COG2113	Glycine betaine
BF638R_RS15300	COG4176	ABC-type proline glycine betaine transport system permease component
BF638R_RS15315	COG2205	protein histidine kinase activity
BF638R_RS15315	COG3292	Two component regulator propeller
BF638R_RS15315	COG0745	RESPONSE REGULATOR receiver
BF638R_RS15320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BF638R_RS15320	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BF638R_RS15330	COG1621	beta-fructofuranosidase activity
BF638R_RS15355	COG0738	Major facilitator superfamily
BF638R_RS15370	COG1752	Esterase of the alpha-beta hydrolase superfamily
BF638R_RS15375	COG0475	glutathione-regulated potassium exporter activity
BF638R_RS15400	COG3015	lipoprotein NlpE involved in copper resistance
BF638R_RS15420	COG1917	Cupin 2, conserved barrel domain protein
BF638R_RS15420	COG4977	sequence-specific DNA binding
BF638R_RS15445	COG4771	TonB-dependent receptor
BF638R_RS15450	COG0702	epimerase
BF638R_RS15465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BF638R_RS15485	COG0484	heat shock protein binding
BF638R_RS15495	COG2194	sulfuric ester hydrolase activity
BF638R_RS15540	COG0028	Belongs to the TPP enzyme family
BF638R_RS15565	COG0459	protein refolding
BF638R_RS15570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BF638R_RS15610	COG2326	polyphosphate kinase activity
BF638R_RS15645	COG3537	Alpha-1,2-mannosidase
BF638R_RS15650	COG1506	peptidase
BF638R_RS15650	COG0823	Involved in the tonB-independent uptake of proteins
BF638R_RS15685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BF638R_RS15725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF638R_RS15735	COG0671	phosphoesterase, PA-phosphatase related
BF638R_RS15755	COG0702	epimerase
BF638R_RS15760	COG4771	TonB-dependent receptor
BF638R_RS15780	COG0463	Glycosyl transferase, family 2
BF638R_RS15795	COG0066	3-isopropylmalate dehydratase activity
BF638R_RS15800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BF638R_RS15805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BF638R_RS15855	COG0616	signal peptide processing
BF638R_RS15865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BF638R_RS15870	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BF638R_RS15940	COG1431	PFAM Stem cell self-renewal protein Piwi
BF638R_RS15945	COG0546	phosphoglycolate phosphatase activity
BF638R_RS15960	COG2207	Transcriptional regulator
BF638R_RS15965	COG0745	RESPONSE REGULATOR receiver
BF638R_RS15965	COG3292	Two component regulator propeller
BF638R_RS15965	COG2205	protein histidine kinase activity
BF638R_RS15970	COG4948	Mandelate Racemase Muconate Lactonizing
BF638R_RS15990	COG0702	epimerase
BF638R_RS15995	COG1629	transport
BF638R_RS15995	COG4206	TonB-dependent receptor
BF638R_RS16025	COG1917	Cupin 2, conserved barrel domain protein
BF638R_RS16025	COG2207	Transcriptional regulator
BF638R_RS16040	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BF638R_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
BF638R_RS16120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BF638R_RS16130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BF638R_RS16130	COG4651	solute:proton antiporter activity
BF638R_RS16135	COG0439	Biotin carboxylase
BF638R_RS16140	COG5016	pyruvate
BF638R_RS16140	COG0511	ligase activity, forming carbon-carbon bonds
BF638R_RS16145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BF638R_RS16150	COG1335	isochorismatase
BF638R_RS16160	COG0516	GMP reductase activity
BF638R_RS16160	COG0517	IMP dehydrogenase activity
BF638R_RS16175	COG2207	Transcriptional regulator
BF638R_RS16180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF638R_RS16195	COG2873	o-acetylhomoserine
BF638R_RS16255	COG2217	Heavy metal translocating P-type atpase
BF638R_RS16265	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF638R_RS16275	COG0741	lytic transglycosylase activity
BF638R_RS16275	COG1388	LysM domain
BF638R_RS16280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BF638R_RS16285	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BF638R_RS16285	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BF638R_RS16295	COG1285	pathogenesis
BF638R_RS16315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF638R_RS16315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF638R_RS16330	COG1115	amino acid carrier protein
BF638R_RS16340	COG1509	lysine 2,3-aminomutase activity
BF638R_RS16345	COG2233	PERMEase
BF638R_RS16360	COG1393	Belongs to the ArsC family
BF638R_RS16370	COG4206	TonB-dependent receptor
BF638R_RS16370	COG1629	transport
BF638R_RS16385	COG4589	Belongs to the CDS family
BF638R_RS16395	COG2304	oxidoreductase activity
BF638R_RS16405	COG0351	phosphomethylpyrimidine kinase
BF638R_RS16415	COG1139	Iron-sulfur cluster binding protein
BF638R_RS16420	COG0247	lactate metabolic process
BF638R_RS16425	COG0602	queuosine metabolic process
BF638R_RS16435	COG2832	Protein of unknown function (DUF454)
BF638R_RS16440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BF638R_RS16455	COG3142	Participates in the control of copper homeostasis
BF638R_RS16460	COG1418	mRNA catabolic process
BF638R_RS16480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BF638R_RS16495	COG4771	TonB-dependent receptor
BF638R_RS16610	COG0617	tRNA 3'-terminal CCA addition
BF638R_RS16610	COG0517	IMP dehydrogenase activity
BF638R_RS16610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BF638R_RS16635	COG0612	Peptidase, M16
BF638R_RS16645	COG1278	Cold shock
BF638R_RS16680	COG0438	transferase activity, transferring glycosyl groups
BF638R_RS16685	COG1216	Glycosyl transferase, family 2
BF638R_RS16690	COG0463	Glycosyl transferase, family 2
BF638R_RS16700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF638R_RS16715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BF638R_RS16725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF638R_RS16770	COG0776	regulation of translation
BF638R_RS16775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BF638R_RS16805	COG0632	four-way junction helicase activity
BF638R_RS16810	COG0673	inositol 2-dehydrogenase activity
BF638R_RS16815	COG1272	protein, Hemolysin III
BF638R_RS16820	COG1328	CTP reductase activity
BF638R_RS16830	COG2814	Major facilitator Superfamily
BF638R_RS16840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BF638R_RS16850	COG0750	zinc metalloprotease
BF638R_RS16865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BF638R_RS16870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BF638R_RS16880	COG1214	PFAM Peptidase M22, glycoprotease
BF638R_RS16895	COG0194	GDP metabolic process
BF638R_RS16900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BF638R_RS16905	COG1408	metallophosphoesterase
BF638R_RS16910	COG1575	Belongs to the MenA family. Type 1 subfamily
BF638R_RS16915	COG1088	dTDP-glucose 4,6-dehydratase activity
BF638R_RS16920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BF638R_RS16930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BF638R_RS16940	COG2204	response regulator
BF638R_RS16945	COG0488	(ABC) transporter
BF638R_RS17015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BF638R_RS17025	COG1522	sequence-specific DNA binding
BF638R_RS17050	COG0811	peptide transport
BF638R_RS17060	COG0084	hydrolase, TatD family'
BF638R_RS17075	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BF638R_RS17080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BF638R_RS17085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BF638R_RS17090	COG0205	6-phosphofructokinase activity
BF638R_RS17110	COG0372	Belongs to the citrate synthase family
BF638R_RS17115	COG0538	isocitrate dehydrogenase activity
BF638R_RS17125	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BF638R_RS17135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BF638R_RS17160	COG0129	dihydroxy-acid dehydratase activity
BF638R_RS17185	COG2885	chlorophyll binding
BF638R_RS17205	COG3681	Belongs to the UPF0597 family
BF638R_RS17240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BF638R_RS17250	COG0702	epimerase
BF638R_RS17255	COG4771	TonB-dependent receptor
BF638R_RS17270	COG0702	epimerase
BF638R_RS17275	COG1629	transport
BF638R_RS17275	COG4206	TonB-dependent receptor
BF638R_RS17290	COG4771	TonB-dependent receptor
BF638R_RS17345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BF638R_RS17345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BF638R_RS17350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BF638R_RS17385	COG0534	Mate efflux family protein
BF638R_RS17390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BF638R_RS17395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BF638R_RS17400	COG0166	Belongs to the GPI family
BF638R_RS17410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BF638R_RS17580	COG0863	Belongs to the N(4) N(6)-methyltransferase family
BF638R_RS17675	COG2502	aspartate--ammonia ligase
BF638R_RS17680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BF638R_RS17695	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS17710	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF638R_RS17720	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BF638R_RS17735	COG1640	4-alpha-glucanotransferase
BF638R_RS17745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BF638R_RS17750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF638R_RS17775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BF638R_RS17780	COG1022	Amp-dependent synthetase and ligase
BF638R_RS17790	COG0359	binds to the 23S rRNA
BF638R_RS17795	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BF638R_RS17800	COG0360	Binds together with S18 to 16S ribosomal RNA
BF638R_RS17820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BF638R_RS17830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF638R_RS17850	COG4771	TonB-dependent receptor
BF638R_RS17865	COG2431	L-lysine efflux transmembrane transporter activity
BF638R_RS17895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BF638R_RS17900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BF638R_RS17905	COG0386	Belongs to the glutathione peroxidase family
BF638R_RS17925	COG3275	phosphorelay sensor kinase activity
BF638R_RS17930	COG3279	Response regulator of the LytR AlgR family
BF638R_RS17950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BF638R_RS17965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BF638R_RS17975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BF638R_RS17980	COG0658	competence protein
BF638R_RS17985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BF638R_RS17990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BF638R_RS18000	COG0009	L-threonylcarbamoyladenylate synthase
BF638R_RS18025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF638R_RS18050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BF638R_RS18080	COG1216	Glycosyl transferase, family 2
BF638R_RS18085	COG2089	acid synthase
BF638R_RS18090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF638R_RS18095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BF638R_RS18110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF638R_RS18115	COG1086	Polysaccharide biosynthesis protein
BF638R_RS18125	COG1086	Polysaccharide biosynthesis protein
BF638R_RS18165	COG2818	Glycosylase
BF638R_RS18170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BF638R_RS18170	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BF638R_RS18175	COG0514	ATP-dependent DNA helicase (RecQ)
BF638R_RS18185	COG2271	Major facilitator Superfamily
BF638R_RS18200	COG0702	epimerase
BF638R_RS18205	COG4771	TonB-dependent receptor
BF638R_RS18210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BF638R_RS18215	COG2186	Transcriptional regulator
BF638R_RS18225	COG0436	Aminotransferase
BF638R_RS18230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BF638R_RS18245	COG0358	DNA primase activity
BF638R_RS18250	COG3119	arylsulfatase activity
BF638R_RS18265	COG1629	transport
BF638R_RS18265	COG4206	TonB-dependent receptor
BF638R_RS18280	COG0302	gtp cyclohydrolase
BF638R_RS18290	COG0149	triose-phosphate isomerase activity
BF638R_RS18305	COG0739	heme binding
BF638R_RS18310	COG0105	UTP biosynthetic process
BF638R_RS18315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BF638R_RS18340	COG0811	peptide transport
BF638R_RS18350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BF638R_RS18405	COG1629	transport
BF638R_RS18440	COG0039	L-malate dehydrogenase activity
BF638R_RS18470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF638R_RS18485	COG4948	Mandelate Racemase Muconate Lactonizing
BF638R_RS18505	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BF638R_RS18510	COG3118	belongs to the thioredoxin family
BF638R_RS18515	COG0489	protein tyrosine kinase activity
BF638R_RS18530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF638R_RS18535	COG1722	exodeoxyribonuclease VII activity
BF638R_RS18540	COG1570	exodeoxyribonuclease VII activity
BF638R_RS18550	COG0482	sulfurtransferase activity
BF638R_RS18575	COG0179	Fumarylacetoacetate (FAA) hydrolase
BF638R_RS18580	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BF638R_RS18590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BF638R_RS18595	COG0052	Belongs to the universal ribosomal protein uS2 family
BF638R_RS18600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BF638R_RS18605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BF638R_RS18615	COG0017	Asparaginyl-tRNA synthetase
BF638R_RS18620	COG1187	pseudouridine synthase activity
BF638R_RS18650	COG0110	maltose O-acetyltransferase activity
BF638R_RS18655	COG3022	response to hydroperoxide
BF638R_RS18660	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS18715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BF638R_RS18750	COG1216	Glycosyl transferase, family 2
BF638R_RS18750	COG1442	glycosyl transferase family 8
BF638R_RS18775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BF638R_RS18790	COG0297	glycogen (starch) synthase activity
BF638R_RS18840	COG0297	glycogen (starch) synthase activity
BF638R_RS18865	COG0745	RESPONSE REGULATOR receiver
BF638R_RS18920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BF638R_RS18935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BF638R_RS18950	COG0516	GMP reductase activity
BF638R_RS18950	COG0517	IMP dehydrogenase activity
BF638R_RS18955	COG0514	ATP-dependent DNA helicase (RecQ)
BF638R_RS18960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BF638R_RS18980	COG0724	RNA recognition motif
BF638R_RS18990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BF638R_RS18995	COG1127	ABC transporter
BF638R_RS19000	COG2197	response regulator
BF638R_RS19005	COG1160	GTP binding
BF638R_RS19010	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BF638R_RS19015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF638R_RS19065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BF638R_RS19070	COG0470	DNA polymerase III
BF638R_RS19075	COG1774	PSP1 C-terminal conserved region
BF638R_RS19085	COG0772	Belongs to the SEDS family
BF638R_RS19100	COG1792	Involved in formation and maintenance of cell shape
BF638R_RS19110	COG0138	bifunctional purine biosynthesis protein purh
BF638R_RS19115	COG3590	peptidase
BF638R_RS19120	COG0488	(ABC) transporter
BF638R_RS19145	COG2205	protein histidine kinase activity
BF638R_RS19145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF638R_RS19150	COG0534	Mate efflux family protein
BF638R_RS19155	COG0612	Peptidase, M16
BF638R_RS19175	COG0564	pseudouridine synthase activity
BF638R_RS19230	COG1131	(ABC) transporter
BF638R_RS19250	COG2312	Erythromycin esterase
BF638R_RS19305	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BF638R_RS19325	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
BF638R_RS19340	COG1696	Membrane protein involved in D-alanine export
BF638R_RS19380	COG2986	histidine ammonia-lyase
BF638R_RS19390	COG1228	amidohydrolase
BF638R_RS19400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BF638R_RS19430	COG0203	ribosomal protein L17
BF638R_RS19435	COG0202	RNA polymerase activity
BF638R_RS19440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BF638R_RS19445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BF638R_RS19450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BF638R_RS19455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BF638R_RS19470	COG0200	Binds to the 23S rRNA
BF638R_RS19475	COG1841	ribosomal large subunit assembly
BF638R_RS19480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BF638R_RS19485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BF638R_RS19490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BF638R_RS19495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BF638R_RS19500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BF638R_RS19505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BF638R_RS19510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BF638R_RS19515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BF638R_RS19520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BF638R_RS19525	COG0255	Belongs to the universal ribosomal protein uL29 family
BF638R_RS19530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BF638R_RS19535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BF638R_RS19540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BF638R_RS19545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BF638R_RS19550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BF638R_RS19555	COG0089	rRNA binding
BF638R_RS19560	COG0088	Forms part of the polypeptide exit tunnel
BF638R_RS19565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BF638R_RS19570	COG0051	transcription antitermination factor activity, RNA binding
BF638R_RS19575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BF638R_RS19580	COG0049	tRNA binding
BF638R_RS19585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BF638R_RS19620	COG0085	RNA polymerase activity
BF638R_RS19625	COG0222	ribosome binding
BF638R_RS19630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BF638R_RS19635	COG0081	regulation of translation
BF638R_RS19640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BF638R_RS19685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BF638R_RS19690	COG4974	Belongs to the 'phage' integrase family
BF638R_RS19695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BF638R_RS19705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BF638R_RS19715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BF638R_RS19720	COG1480	7TM receptor with intracellular HD hydrolase
BF638R_RS19725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BF638R_RS19735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BF638R_RS19755	COG1027	Aspartate ammonia-lyase
BF638R_RS19760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BF638R_RS19765	COG0252	asparaginase activity
BF638R_RS19800	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BF638R_RS19810	COG4804	nuclease activity
BF638R_RS19845	COG0745	RESPONSE REGULATOR receiver
BF638R_RS19845	COG2205	protein histidine kinase activity
BF638R_RS19845	COG3292	Two component regulator propeller
BF638R_RS19875	COG2271	Major facilitator Superfamily
BF638R_RS19885	COG4771	TonB-dependent receptor
BF638R_RS19890	COG0702	epimerase
BF638R_RS19900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF638R_RS19915	COG4771	TonB-dependent receptor
BF638R_RS19965	COG1484	DNA-dependent DNA replication
BF638R_RS20020	COG2096	Adenosyltransferase
BF638R_RS20080	COG1629	transport
BF638R_RS20105	COG0657	acetylesterase activity
BF638R_RS20105	COG2755	lipolytic protein G-D-S-L family
BF638R_RS20150	COG3275	phosphorelay sensor kinase activity
BF638R_RS20155	COG3279	Response regulator of the LytR AlgR family
BF638R_RS20170	COG4206	TonB-dependent receptor
BF638R_RS20190	COG2197	response regulator
BF638R_RS20205	COG2207	Transcriptional regulator
BF638R_RS20205	COG0662	Cupin 2, conserved barrel domain protein
BF638R_RS20210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BF638R_RS20235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF638R_RS20290	COG0358	DNA primase activity
BF638R_RS20315	COG4974	Belongs to the 'phage' integrase family
BF638R_RS20325	COG1629	transport
BF638R_RS20325	COG4206	TonB-dependent receptor
BF638R_RS20340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BF638R_RS20380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BF638R_RS20390	COG1185	polyribonucleotide nucleotidyltransferase activity
BF638R_RS20405	COG4771	TonB-dependent receptor
BF638R_RS20430	COG3426	butyrate kinase activity
BF638R_RS20435	COG0280	phosphate acetyltransferase
BF638R_RS20445	COG1619	proteins homologs of microcin C7 resistance protein MccF
BF638R_RS20450	COG2234	aminopeptidase activity
BF638R_RS20455	COG2166	iron-sulfur cluster assembly
BF638R_RS20460	COG3655	Transcriptional regulator
BF638R_RS20470	COG1266	CAAX protease self-immunity
BF638R_RS20480	COG0196	riboflavin kinase activity
BF638R_RS20485	COG1011	Hydrolase
BF638R_RS20490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BF638R_RS20500	COG1773	rubredoxin
BF638R_RS20505	COG1283	sodium-dependent phosphate transmembrane transporter activity
BF638R_RS20515	COG2205	protein histidine kinase activity
BF638R_RS20540	COG0006	proline dipeptidase activity
BF638R_RS20555	COG0509	glycine decarboxylation via glycine cleavage system
BF638R_RS20560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BF638R_RS20585	COG0702	epimerase
BF638R_RS20590	COG4771	TonB-dependent receptor
BF638R_RS20605	COG0793	Belongs to the peptidase S41A family
BF638R_RS20610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BF638R_RS20645	COG4771	TonB-dependent receptor
BF638R_RS20650	COG0745	RESPONSE REGULATOR receiver
BF638R_RS20650	COG2205	protein histidine kinase activity
BF638R_RS20650	COG3292	Two component regulator propeller
BF638R_RS20655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BF638R_RS20660	COG1882	Formate acetyltransferase
BF638R_RS20665	COG2814	Major facilitator Superfamily
BF638R_RS20685	COG1040	competence protein
BF638R_RS20690	COG0483	inositol monophosphate 1-phosphatase activity
BF638R_RS20700	COG3345	alpha-galactosidase
BF638R_RS20730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BF638R_RS20765	COG1442	glycosyl transferase family 8
BF638R_RS20845	COG0018	arginyl-trna synthetase
BF638R_RS20875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BF638R_RS20880	COG0776	regulation of translation
BF638R_RS20915	COG2207	Transcriptional regulator
BF638R_RS20915	COG1609	Transcriptional regulator
BF638R_RS20930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BF638R_RS20930	COG0674	pyruvate-flavodoxin oxidoreductase activity
BF638R_RS20935	COG1013	pyruvate-flavodoxin oxidoreductase activity
BF638R_RS20945	COG0584	glycerophosphoryl diester phosphodiesterase
BF638R_RS20950	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BF638R_RS20955	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BF638R_RS20960	COG1629	transport
BF638R_RS20970	COG1629	transport
BF638R_RS20985	COG5434	Belongs to the glycosyl hydrolase 28 family
BF638R_RS21010	COG1629	transport
BF638R_RS21020	COG1217	gtp-binding protein TYPA
BF638R_RS21025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BF638R_RS21035	COG0318	PFAM AMP-dependent synthetase and ligase
BF638R_RS21040	COG2205	protein histidine kinase activity
BF638R_RS21040	COG5002	protein histidine kinase activity
BF638R_RS21040	COG0784	Response regulator, receiver
BF638R_RS21060	COG3119	arylsulfatase activity
BF638R_RS21070	COG4206	TonB-dependent receptor
BF638R_RS21070	COG1629	transport
BF638R_RS21085	COG4591	ABC-type transport system involved in lipoprotein release permease component
BF638R_RS21090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BF638R_RS21105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BF638R_RS21110	COG4974	Belongs to the 'phage' integrase family
BF638R_RS21120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF638R_RS21125	COG0606	chelatase, subunit chli
BF638R_RS21185	COG4474	Belongs to the UPF0398 family
BF638R_RS21190	COG1475	DNA binding
BF638R_RS21210	COG2003	Belongs to the UPF0758 family
BF638R_RS21345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BF638R_RS21350	COG1970	mechanosensitive ion channel activity
BF638R_RS21355	COG0776	regulation of translation
BF638R_RS21385	COG0551	DNA topoisomerase type I activity
BF638R_RS21385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF638R_RS21390	COG4804	nuclease activity
BF638R_RS21480	COG1475	DNA binding
BF638R_RS21485	COG3969	phosphoadenosine phosphosulfate
BF638R_RS21500	COG4771	TonB-dependent receptor
BF638R_RS21520	COG0745	RESPONSE REGULATOR receiver
BF638R_RS21520	COG3292	Two component regulator propeller
BF638R_RS21520	COG2205	protein histidine kinase activity
BF638R_RS21580	COG0438	transferase activity, transferring glycosyl groups
BF638R_RS21605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BF638R_RS21610	COG0438	transferase activity, transferring glycosyl groups
BF638R_RS21620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BF638R_RS21625	COG0545	Peptidyl-prolyl cis-trans isomerase
BF638R_RS21630	COG0545	Peptidyl-prolyl cis-trans isomerase
BF638R_RS21635	COG1522	sequence-specific DNA binding
BF638R_RS21655	COG3275	phosphorelay sensor kinase activity
BF638R_RS21725	COG4206	TonB-dependent receptor
BF638R_RS21725	COG1629	transport
BF638R_RS21735	COG2814	Major facilitator Superfamily
BF638R_RS21755	COG3292	Two component regulator propeller
BF638R_RS21755	COG0745	RESPONSE REGULATOR receiver
BF638R_RS21755	COG2205	protein histidine kinase activity
BF638R_RS21760	COG1621	beta-fructofuranosidase activity
BF638R_RS21795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BF638R_RS21800	COG3409	Peptidoglycan-binding domain 1 protein
BF638R_RS21800	COG0793	Belongs to the peptidase S41A family
BF638R_RS21820	COG1053	succinate dehydrogenase
BF638R_RS21825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BF638R_RS21840	COG4771	TonB-dependent receptor
BF638R_RS21865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BF638R_RS21865	COG0758	DNA mediated transformation
BF638R_RS21875	COG0826	peptidase U32
BF638R_RS21885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BF638R_RS21900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BF638R_RS21905	COG0557	exoribonuclease II activity
BF638R_RS21930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF638R_RS21945	COG0012	GTP binding
BF638R_RS21950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BF638R_RS21955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BF638R_RS21965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BF638R_RS21975	COG0495	leucyl-tRNA aminoacylation
BF638R_RS21980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF638R_RS21990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate