locus-tag	class	description
K6V22_RS00065	COG4227	nucleotidyltransferase activity
K6V22_RS00165	COG0739	heme binding
K6V22_RS00165	COG0741	lytic transglycosylase activity
K6V22_RS00165	COG1196	nuclear chromosome segregation
K6V22_RS00205	COG0776	regulation of translation
K6V22_RS00230	COG0681	Belongs to the peptidase S26 family
K6V22_RS00235	COG0681	Belongs to the peptidase S26 family
K6V22_RS00240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6V22_RS00270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V22_RS00285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V22_RS00290	COG3250	beta-galactosidase activity
K6V22_RS00315	COG0561	phosphatase activity
K6V22_RS00320	COG0745	RESPONSE REGULATOR receiver
K6V22_RS00375	COG5002	protein histidine kinase activity
K6V22_RS00380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6V22_RS00395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6V22_RS00410	COG0205	6-phosphofructokinase activity
K6V22_RS00420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6V22_RS00425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6V22_RS00430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6V22_RS00435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6V22_RS00450	COG1442	glycosyl transferase family 8
K6V22_RS00460	COG1215	transferase activity, transferring glycosyl groups
K6V22_RS00465	COG1442	glycosyl transferase family 8
K6V22_RS00465	COG1216	Glycosyl transferase, family 2
K6V22_RS00470	COG1132	(ABC) transporter
K6V22_RS00480	COG0328	RNA-DNA hybrid ribonuclease activity
K6V22_RS00480	COG3341	Caulimovirus viroplasmin
K6V22_RS00490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6V22_RS00500	COG0326	Molecular chaperone. Has ATPase activity
K6V22_RS00510	COG1166	arginine decarboxylase activity
K6V22_RS00515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6V22_RS00590	COG1454	alcohol dehydrogenase
K6V22_RS00595	COG0235	Class ii aldolase
K6V22_RS00600	COG1070	Carbohydrate kinase
K6V22_RS00605	COG0738	Major facilitator superfamily
K6V22_RS00625	COG0779	Required for maturation of 30S ribosomal subunits
K6V22_RS00630	COG0195	Participates in both transcription termination and antitermination
K6V22_RS00635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6V22_RS00645	COG0719	Fe-S assembly protein
K6V22_RS00655	COG0396	ATPase activity
K6V22_RS00660	COG0719	Fe-S assembly protein
K6V22_RS00665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6V22_RS00670	COG0393	Putative heavy-metal-binding
K6V22_RS00685	COG4771	TonB-dependent receptor
K6V22_RS00710	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K6V22_RS00730	COG2205	protein histidine kinase activity
K6V22_RS00730	COG2202	Pas domain
K6V22_RS00750	COG0187	DNA topoisomerase II activity
K6V22_RS00755	COG0268	Binds directly to 16S ribosomal RNA
K6V22_RS00765	COG1381	Involved in DNA repair and RecF pathway recombination
K6V22_RS00770	COG1610	YqeY-like protein
K6V22_RS00775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6V22_RS00790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6V22_RS00795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6V22_RS00800	COG0772	Belongs to the SEDS family
K6V22_RS00805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6V22_RS00810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V22_RS00835	COG2001	Belongs to the MraZ family
K6V22_RS00855	COG4771	TonB-dependent receptor
K6V22_RS00880	COG0756	dUTP diphosphatase activity
K6V22_RS00895	COG4942	peptidase
K6V22_RS00900	COG0745	RESPONSE REGULATOR receiver
K6V22_RS00900	COG2205	protein histidine kinase activity
K6V22_RS00900	COG3292	Two component regulator propeller
K6V22_RS00905	COG3940	Belongs to the glycosyl hydrolase 43 family
K6V22_RS00920	COG3250	beta-galactosidase activity
K6V22_RS00935	COG3940	Belongs to the glycosyl hydrolase 43 family
K6V22_RS00950	COG0383	alpha-mannosidase activity
K6V22_RS00950	COG0383	alpha-mannosidase activity
K6V22_RS00955	COG1629	transport
K6V22_RS00955	COG4206	TonB-dependent receptor
K6V22_RS00975	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V22_RS01000	COG3537	Alpha-1,2-mannosidase
K6V22_RS01010	COG2017	converts alpha-aldose to the beta-anomer
K6V22_RS01080	COG3408	Glycogen debranching enzyme
K6V22_RS01085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6V22_RS01090	COG1022	Amp-dependent synthetase and ligase
K6V22_RS01105	COG2954	triphosphatase activity
K6V22_RS01125	COG3250	beta-galactosidase activity
K6V22_RS01130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS01140	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V22_RS01155	COG1629	transport
K6V22_RS01155	COG4206	TonB-dependent receptor
K6V22_RS01160	COG2205	protein histidine kinase activity
K6V22_RS01160	COG3292	Two component regulator propeller
K6V22_RS01160	COG0745	RESPONSE REGULATOR receiver
K6V22_RS01165	COG3292	Two component regulator propeller
K6V22_RS01165	COG2205	protein histidine kinase activity
K6V22_RS01165	COG0745	RESPONSE REGULATOR receiver
K6V22_RS01190	COG4771	TonB-dependent receptor
K6V22_RS01205	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
K6V22_RS01225	COG4771	TonB-dependent receptor
K6V22_RS01250	COG0423	glycine-tRNA ligase activity
K6V22_RS01255	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V22_RS01310	COG4771	TonB-dependent receptor
K6V22_RS01315	COG2205	protein histidine kinase activity
K6V22_RS01315	COG0745	RESPONSE REGULATOR receiver
K6V22_RS01315	COG3292	Two component regulator propeller
K6V22_RS01315	COG2205	protein histidine kinase activity
K6V22_RS01315	COG0745	RESPONSE REGULATOR receiver
K6V22_RS01315	COG3292	Two component regulator propeller
K6V22_RS01325	COG3005	denitrification pathway
K6V22_RS01330	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K6V22_RS01340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V22_RS01360	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6V22_RS01380	COG3876	Protein conserved in bacteria
K6V22_RS01415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6V22_RS01420	COG3876	Protein conserved in bacteria
K6V22_RS01425	COG0702	epimerase
K6V22_RS01430	COG1629	transport
K6V22_RS01430	COG4206	TonB-dependent receptor
K6V22_RS01440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6V22_RS01445	COG0589	response to stress
K6V22_RS01445	COG0475	glutathione-regulated potassium exporter activity
K6V22_RS01450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6V22_RS01465	COG0733	neurotransmitter:sodium symporter activity
K6V22_RS01475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6V22_RS01485	COG0076	glutamate decarboxylase activity
K6V22_RS01490	COG2066	Belongs to the glutaminase family
K6V22_RS01495	COG0784	Response regulator, receiver
K6V22_RS01495	COG2198	Histidine kinase
K6V22_RS01495	COG5002	protein histidine kinase activity
K6V22_RS01500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6V22_RS01505	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K6V22_RS01565	COG1346	cytolysis
K6V22_RS01590	COG0280	phosphate acetyltransferase
K6V22_RS01595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6V22_RS01600	COG1785	Belongs to the alkaline phosphatase family
K6V22_RS01605	COG2151	metal-sulfur cluster biosynthetic enzyme
K6V22_RS01610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V22_RS01615	COG2003	Belongs to the UPF0758 family
K6V22_RS01620	COG1216	Glycosyl transferase, family 2
K6V22_RS01620	COG0463	Glycosyl transferase, family 2
K6V22_RS01630	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K6V22_RS01635	COG0515	serine threonine protein kinase
K6V22_RS01635	COG2815	serine threonine protein kinase
K6V22_RS01640	COG0564	pseudouridine synthase activity
K6V22_RS01680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6V22_RS01685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6V22_RS01695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6V22_RS01715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6V22_RS01725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V22_RS01725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V22_RS01730	COG2890	protein-(glutamine-N5) methyltransferase activity
K6V22_RS01735	COG2137	regulation of response to DNA damage stimulus
K6V22_RS01740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6V22_RS01775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6V22_RS01780	COG1396	sequence-specific DNA binding
K6V22_RS01780	COG1917	Cupin 2, conserved barrel domain protein
K6V22_RS01785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6V22_RS01790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6V22_RS01795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6V22_RS01800	COG0137	argininosuccinate synthase activity
K6V22_RS01810	COG1438	arginine binding
K6V22_RS01825	COG2205	protein histidine kinase activity
K6V22_RS01825	COG3437	response regulator, receiver
K6V22_RS01825	COG3850	Histidine kinase
K6V22_RS01825	COG4999	Histidine kinase
K6V22_RS01830	COG0531	amino acid
K6V22_RS01840	COG0039	L-malate dehydrogenase activity
K6V22_RS01845	COG2996	Protein conserved in bacteria
K6V22_RS01865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6V22_RS01870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V22_RS01895	COG1629	transport
K6V22_RS01920	COG0577	efflux transmembrane transporter activity
K6V22_RS01920	COG1136	(ABC) transporter
K6V22_RS01925	COG0577	efflux transmembrane transporter activity
K6V22_RS01925	COG1136	(ABC) transporter
K6V22_RS01930	COG1136	(ABC) transporter
K6V22_RS01935	COG1940	carbohydrate kinase activity
K6V22_RS01940	COG0335	large ribosomal subunit rRNA binding
K6V22_RS01945	COG0737	Belongs to the 5'-nucleotidase family
K6V22_RS01950	COG0737	Belongs to the 5'-nucleotidase family
K6V22_RS01955	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V22_RS01960	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V22_RS01965	COG1629	transport
K6V22_RS01965	COG4206	TonB-dependent receptor
K6V22_RS01975	COG3119	arylsulfatase activity
K6V22_RS02000	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6V22_RS02015	COG2204	response regulator
K6V22_RS02025	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K6V22_RS02045	COG2205	protein histidine kinase activity
K6V22_RS02050	COG5002	protein histidine kinase activity
K6V22_RS02065	COG4771	TonB-dependent receptor
K6V22_RS02110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6V22_RS02110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6V22_RS02115	COG0436	Aminotransferase
K6V22_RS02120	COG3250	beta-galactosidase activity
K6V22_RS02135	COG0826	peptidase U32
K6V22_RS02145	COG4771	TonB-dependent receptor
K6V22_RS02150	COG2197	response regulator
K6V22_RS02155	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K6V22_RS02165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6V22_RS02170	COG0252	asparaginase activity
K6V22_RS02175	COG0527	aspartate kinase activity
K6V22_RS02175	COG0460	homoserine dehydrogenase
K6V22_RS02180	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
K6V22_RS02185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6V22_RS02245	COG4771	TonB-dependent receptor
K6V22_RS02265	COG3250	beta-galactosidase activity
K6V22_RS02270	COG3250	beta-galactosidase activity
K6V22_RS02280	COG3250	beta-galactosidase activity
K6V22_RS02290	COG4206	TonB-dependent receptor
K6V22_RS02290	COG1629	transport
K6V22_RS02295	COG4771	TonB-dependent receptor
K6V22_RS02340	COG4771	TonB-dependent receptor
K6V22_RS02360	COG0628	permease
K6V22_RS02375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6V22_RS02390	COG2095	MarC family integral membrane protein
K6V22_RS02400	COG4206	TonB-dependent receptor
K6V22_RS02400	COG1629	transport
K6V22_RS02405	COG4974	Belongs to the 'phage' integrase family
K6V22_RS02410	COG1629	transport
K6V22_RS02420	COG1629	transport
K6V22_RS02420	COG4206	TonB-dependent receptor
K6V22_RS02430	COG4771	TonB-dependent receptor
K6V22_RS02435	COG0702	epimerase
K6V22_RS02440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6V22_RS02455	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V22_RS02455	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V22_RS02470	COG0531	amino acid
K6V22_RS02480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6V22_RS02485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V22_RS02495	COG1162	GTPase activity
K6V22_RS02500	COG0233	cytoplasmic translational termination
K6V22_RS02520	COG0443	Heat shock 70 kDa protein
K6V22_RS02535	COG0528	UMP kinase activity
K6V22_RS02540	COG0534	Mate efflux family protein
K6V22_RS02570	COG0792	nuclease activity
K6V22_RS02590	COG1183	phosphatidylcholine synthase activity
K6V22_RS02595	COG0688	phosphatidylethanolamine metabolic process
K6V22_RS02605	COG3118	belongs to the thioredoxin family
K6V22_RS02640	COG0714	Associated with various cellular activities
K6V22_RS02655	COG0802	atpase or kinase
K6V22_RS02660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6V22_RS02670	COG2234	aminopeptidase activity
K6V22_RS02690	COG1629	transport
K6V22_RS02710	COG3250	beta-galactosidase activity
K6V22_RS02715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K6V22_RS02725	COG2205	protein histidine kinase activity
K6V22_RS02725	COG0784	Response regulator, receiver
K6V22_RS02775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6V22_RS02790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6V22_RS02795	COG0742	ribosomal rna small subunit methyltransferase
K6V22_RS02820	COG4771	TonB-dependent receptor
K6V22_RS02830	COG3537	Alpha-1,2-mannosidase
K6V22_RS02845	COG3537	Alpha-1,2-mannosidase
K6V22_RS02850	COG2814	Major facilitator Superfamily
K6V22_RS02865	COG0739	heme binding
K6V22_RS02875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V22_RS02880	COG3942	CHAP domain
K6V22_RS02880	COG1388	LysM domain
K6V22_RS02890	COG1475	DNA binding
K6V22_RS02895	COG1192	Involved in chromosome partitioning
K6V22_RS02900	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6V22_RS02905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V22_RS02915	COG4589	Belongs to the CDS family
K6V22_RS02920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6V22_RS02925	COG0799	negative regulation of ribosome biogenesis
K6V22_RS02940	COG2239	Acts as a magnesium transporter
K6V22_RS02945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6V22_RS02955	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V22_RS03025	COG0668	transmembrane transport
K6V22_RS03030	COG0662	Cupin 2, conserved barrel domain protein
K6V22_RS03030	COG2207	Transcriptional regulator
K6V22_RS03105	COG1215	transferase activity, transferring glycosyl groups
K6V22_RS03115	COG1216	Glycosyl transferase, family 2
K6V22_RS03115	COG1442	glycosyl transferase family 8
K6V22_RS03120	COG1086	Polysaccharide biosynthesis protein
K6V22_RS03125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V22_RS03130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K6V22_RS03155	COG1696	Membrane protein involved in D-alanine export
K6V22_RS03160	COG1696	Membrane protein involved in D-alanine export
K6V22_RS03175	COG1215	transferase activity, transferring glycosyl groups
K6V22_RS03180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6V22_RS03185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V22_RS03195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V22_RS03215	COG0667	Aldo Keto reductase
K6V22_RS03220	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V22_RS03225	COG4771	TonB-dependent receptor
K6V22_RS03230	COG0702	epimerase
K6V22_RS03270	COG5012	cobalamin binding
K6V22_RS03285	COG4124	Belongs to the glycosyl hydrolase 26 family
K6V22_RS03290	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V22_RS03295	COG2211	Major facilitator Superfamily
K6V22_RS03300	COG2942	2-epimerase
K6V22_RS03335	COG0784	Response regulator, receiver
K6V22_RS03335	COG2205	protein histidine kinase activity
K6V22_RS03335	COG5002	protein histidine kinase activity
K6V22_RS03345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V22_RS03350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6V22_RS03355	COG0713	ATP synthesis coupled electron transport
K6V22_RS03360	COG0839	Belongs to the complex I subunit 6 family
K6V22_RS03370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K6V22_RS03375	COG0649	NAD binding
K6V22_RS03375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V22_RS03380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V22_RS03385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V22_RS03395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V22_RS03400	COG0569	domain protein
K6V22_RS03405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6V22_RS03410	COG1073	alpha beta
K6V22_RS03420	COG0546	phosphoglycolate phosphatase activity
K6V22_RS03425	COG3119	arylsulfatase activity
K6V22_RS03440	COG3119	arylsulfatase activity
K6V22_RS03450	COG4771	TonB-dependent receptor
K6V22_RS03455	COG2205	protein histidine kinase activity
K6V22_RS03455	COG0745	RESPONSE REGULATOR receiver
K6V22_RS03455	COG3292	Two component regulator propeller
K6V22_RS03460	COG2271	Major facilitator Superfamily
K6V22_RS03485	COG0805	protein transport
K6V22_RS03490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6V22_RS03495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6V22_RS03525	COG4585	Histidine kinase
K6V22_RS03545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V22_RS03550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6V22_RS03550	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6V22_RS03555	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V22_RS03560	COG1078	dGTPase activity
K6V22_RS03565	COG0284	orotidine-5'-phosphate decarboxylase activity
K6V22_RS03570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6V22_RS03575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6V22_RS03580	COG1704	LemA family
K6V22_RS03595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6V22_RS03600	COG2226	methyltransferase
K6V22_RS03605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6V22_RS03610	COG1702	phosphate starvation-inducible protein PhoH
K6V22_RS03620	COG2268	Band 7 protein
K6V22_RS03630	COG5434	Belongs to the glycosyl hydrolase 28 family
K6V22_RS03640	COG0101	tRNA pseudouridine synthase activity
K6V22_RS03660	COG3250	beta-galactosidase activity
K6V22_RS03665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6V22_RS03690	COG0457	Tetratricopeptide repeat
K6V22_RS03695	COG2814	Major facilitator Superfamily
K6V22_RS03720	COG0561	phosphatase activity
K6V22_RS03725	COG1629	transport
K6V22_RS03725	COG4206	TonB-dependent receptor
K6V22_RS03735	COG4771	TonB-dependent receptor
K6V22_RS03745	COG1629	transport
K6V22_RS03745	COG4206	TonB-dependent receptor
K6V22_RS03760	COG1629	transport
K6V22_RS03760	COG4206	TonB-dependent receptor
K6V22_RS03765	COG0702	epimerase
K6V22_RS03770	COG0673	inositol 2-dehydrogenase activity
K6V22_RS03810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6V22_RS03815	COG0793	Belongs to the peptidase S41A family
K6V22_RS03820	COG2131	deaminase
K6V22_RS03830	COG0339	signal peptide processing
K6V22_RS03840	COG1970	mechanosensitive ion channel activity
K6V22_RS03845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6V22_RS03845	COG0519	Catalyzes the synthesis of GMP from XMP
K6V22_RS03865	COG4206	TonB-dependent receptor
K6V22_RS03865	COG1629	transport
K6V22_RS03870	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6V22_RS03890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6V22_RS03915	COG1242	4 iron, 4 sulfur cluster binding
K6V22_RS03925	COG0363	glucosamine-6-phosphate deaminase activity
K6V22_RS03935	COG0009	L-threonylcarbamoyladenylate synthase
K6V22_RS03945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V22_RS03950	COG0561	phosphatase activity
K6V22_RS03955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6V22_RS03960	COG2873	o-acetylhomoserine
K6V22_RS04015	COG0297	glycogen (starch) synthase activity
K6V22_RS04025	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K6V22_RS04030	COG0543	2 iron, 2 sulfur cluster binding
K6V22_RS04040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6V22_RS04045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6V22_RS04050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6V22_RS04055	COG0546	phosphoglycolate phosphatase activity
K6V22_RS04060	COG0791	NLP P60 protein
K6V22_RS04075	COG0612	Peptidase, M16
K6V22_RS04080	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6V22_RS04085	COG1597	lipid kinase activity
K6V22_RS04090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6V22_RS04100	COG1136	(ABC) transporter
K6V22_RS04120	COG2211	Major facilitator Superfamily
K6V22_RS04135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6V22_RS04150	COG1674	ftsk spoiiie
K6V22_RS04160	COG0492	ferredoxin-NADP+ reductase activity
K6V22_RS04165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS04200	COG1595	DNA-templated transcription, initiation
K6V22_RS04215	COG3956	TIGRFAM MazG family protein
K6V22_RS04225	COG0525	valine-tRNA ligase activity
K6V22_RS04230	COG0784	Response regulator, receiver
K6V22_RS04230	COG2205	protein histidine kinase activity
K6V22_RS04230	COG2198	Histidine kinase
K6V22_RS04250	COG4771	TonB-dependent receptor
K6V22_RS04265	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6V22_RS04280	COG4206	TonB-dependent receptor
K6V22_RS04280	COG1629	transport
K6V22_RS04285	COG0702	epimerase
K6V22_RS04290	COG3119	arylsulfatase activity
K6V22_RS04295	COG3119	arylsulfatase activity
K6V22_RS04315	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
K6V22_RS04325	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K6V22_RS04345	COG1253	flavin adenine dinucleotide binding
K6V22_RS04355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K6V22_RS04365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6V22_RS04405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6V22_RS04415	COG2226	methyltransferase
K6V22_RS04455	COG1086	Polysaccharide biosynthesis protein
K6V22_RS04495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS04500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V22_RS04515	COG4771	TonB-dependent receptor
K6V22_RS04520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6V22_RS04525	COG0563	adenylate kinase activity
K6V22_RS04530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V22_RS04535	COG1496	oxidoreductase activity
K6V22_RS04555	COG2706	6-phosphogluconolactonase activity
K6V22_RS04590	COG1288	antiporter activity
K6V22_RS04610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6V22_RS04630	COG0564	pseudouridine synthase activity
K6V22_RS04645	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V22_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
K6V22_RS04665	COG3550	peptidyl-serine autophosphorylation
K6V22_RS04695	COG0556	nucleotide-excision repair
K6V22_RS04770	COG4974	Belongs to the 'phage' integrase family
K6V22_RS04780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6V22_RS04785	COG5002	protein histidine kinase activity
K6V22_RS04785	COG0784	Response regulator, receiver
K6V22_RS04790	COG2910	NAD(P)H-binding
K6V22_RS04795	COG2176	DNA-directed DNA polymerase activity
K6V22_RS04805	COG4864	UPF0365 protein
K6V22_RS04820	COG0037	tRNA processing
K6V22_RS04830	COG1477	protein flavinylation
K6V22_RS04835	COG1971	Probably functions as a manganese efflux pump
K6V22_RS04850	COG0463	Glycosyl transferase, family 2
K6V22_RS04865	COG0148	phosphopyruvate hydratase activity
K6V22_RS04875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6V22_RS04880	COG1082	Xylose isomerase domain protein TIM barrel
K6V22_RS04900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6V22_RS04905	COG0193	aminoacyl-tRNA hydrolase activity
K6V22_RS04910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6V22_RS04920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6V22_RS04925	COG1862	Preprotein translocase
K6V22_RS04950	COG0542	response to heat
K6V22_RS04960	COG0583	DNA-binding transcription factor activity
K6V22_RS04965	COG2855	membrane
K6V22_RS04980	COG1595	DNA-templated transcription, initiation
K6V22_RS04995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6V22_RS05015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6V22_RS05035	COG0443	Heat shock 70 kDa protein
K6V22_RS05045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6V22_RS05050	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K6V22_RS05055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V22_RS05070	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V22_RS05205	COG4771	TonB-dependent receptor
K6V22_RS05210	COG0702	epimerase
K6V22_RS05235	COG3392	D12 class N6 adenine-specific DNA methyltransferase
K6V22_RS05245	COG1192	Involved in chromosome partitioning
K6V22_RS05450	COG1629	transport
K6V22_RS05450	COG4206	TonB-dependent receptor
K6V22_RS05460	COG1408	metallophosphoesterase
K6V22_RS05465	COG1368	sulfuric ester hydrolase activity
K6V22_RS05475	COG3634	alkyl hydroperoxide reductase activity
K6V22_RS05505	COG1760	l-serine dehydratase
K6V22_RS05510	COG0598	Magnesium transport protein CorA
K6V22_RS05515	COG1193	negative regulation of DNA recombination
K6V22_RS05565	COG0358	DNA primase activity
K6V22_RS05605	COG1063	alcohol dehydrogenase
K6V22_RS05620	COG3119	arylsulfatase activity
K6V22_RS05625	COG0784	Response regulator, receiver
K6V22_RS05625	COG5002	protein histidine kinase activity
K6V22_RS05630	COG2855	membrane
K6V22_RS05635	COG2217	Heavy metal translocating P-type atpase
K6V22_RS05645	COG2885	chlorophyll binding
K6V22_RS05650	COG3189	MarR family transcriptional regulator
K6V22_RS05655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6V22_RS05660	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V22_RS05665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6V22_RS05680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6V22_RS05680	COG4651	solute:proton antiporter activity
K6V22_RS05685	COG1280	lysine exporter protein (LysE YggA)
K6V22_RS05700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K6V22_RS05710	COG0561	phosphatase activity
K6V22_RS05715	COG1169	isochorismate synthase
K6V22_RS05720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6V22_RS05735	COG4948	Mandelate Racemase Muconate Lactonizing
K6V22_RS05750	COG1082	Xylose isomerase domain protein TIM barrel
K6V22_RS05765	COG4771	TonB-dependent receptor
K6V22_RS05795	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V22_RS05800	COG0783	Belongs to the Dps family
K6V22_RS05805	COG0583	DNA-binding transcription factor activity
K6V22_RS05825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6V22_RS05865	COG1253	flavin adenine dinucleotide binding
K6V22_RS05870	COG0501	Belongs to the peptidase M48B family
K6V22_RS05895	COG2873	o-acetylhomoserine
K6V22_RS05900	COG0482	sulfurtransferase activity
K6V22_RS05905	COG2197	response regulator
K6V22_RS05915	COG1757	Na H antiporter
K6V22_RS05930	COG2814	Major facilitator Superfamily
K6V22_RS05935	COG4953	penicillin-binding protein 1C
K6V22_RS05940	COG2373	Large extracellular alpha-helical protein
K6V22_RS05950	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6V22_RS05950	COG1918	ferrous iron import across plasma membrane
K6V22_RS06035	COG0028	Belongs to the TPP enzyme family
K6V22_RS06035	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
K6V22_RS06040	COG1454	alcohol dehydrogenase
K6V22_RS06050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V22_RS06055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V22_RS06065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V22_RS06070	COG0490	domain, Protein
K6V22_RS06070	COG0471	metal ion transport
K6V22_RS06085	COG0346	lactoylglutathione lyase activity
K6V22_RS06100	COG0259	pyridoxamine-phosphate oxidase activity
K6V22_RS06105	COG1741	Belongs to the pirin family
K6V22_RS06125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V22_RS06155	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6V22_RS06165	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6V22_RS06180	COG1595	DNA-templated transcription, initiation
K6V22_RS06205	COG0686	Belongs to the AlaDH PNT family
K6V22_RS06220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V22_RS06235	COG1629	transport
K6V22_RS06250	COG3345	alpha-galactosidase
K6V22_RS06265	COG0488	(ABC) transporter
K6V22_RS06270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V22_RS06275	COG3059	membrane
K6V22_RS06280	COG1917	Cupin 2, conserved barrel domain protein
K6V22_RS06280	COG2207	Transcriptional regulator
K6V22_RS06285	COG0295	cytidine deaminase activity
K6V22_RS06290	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6V22_RS06290	COG1388	LysM domain
K6V22_RS06300	COG0577	efflux transmembrane transporter activity
K6V22_RS06305	COG0577	efflux transmembrane transporter activity
K6V22_RS06310	COG0577	efflux transmembrane transporter activity
K6V22_RS06320	COG0577	efflux transmembrane transporter activity
K6V22_RS06320	COG1136	(ABC) transporter
K6V22_RS06335	COG1136	(ABC) transporter
K6V22_RS06350	COG1136	(ABC) transporter
K6V22_RS06370	COG2205	protein histidine kinase activity
K6V22_RS06370	COG0784	Response regulator, receiver
K6V22_RS06380	COG2204	response regulator
K6V22_RS06485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS06495	COG0656	L-ascorbic acid biosynthetic process
K6V22_RS06510	COG1215	transferase activity, transferring glycosyl groups
K6V22_RS06525	COG1216	Glycosyl transferase, family 2
K6V22_RS06535	COG0438	transferase activity, transferring glycosyl groups
K6V22_RS06540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS06545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V22_RS06550	COG1530	ribonuclease E activity
K6V22_RS06565	COG3119	arylsulfatase activity
K6V22_RS06570	COG0629	single-stranded DNA binding
K6V22_RS06635	COG4206	TonB-dependent receptor
K6V22_RS06650	COG5002	protein histidine kinase activity
K6V22_RS06655	COG0745	RESPONSE REGULATOR receiver
K6V22_RS06680	COG0488	(ABC) transporter
K6V22_RS06695	COG5492	domain, Protein
K6V22_RS06705	COG0436	Aminotransferase
K6V22_RS06710	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6V22_RS06715	COG1215	transferase activity, transferring glycosyl groups
K6V22_RS06720	COG0628	permease
K6V22_RS06725	COG3852	Histidine kinase
K6V22_RS06740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V22_RS06750	COG1136	(ABC) transporter
K6V22_RS06750	COG0577	efflux transmembrane transporter activity
K6V22_RS06755	COG0577	efflux transmembrane transporter activity
K6V22_RS06760	COG1252	NADH dehydrogenase
K6V22_RS06790	COG4771	TonB-dependent receptor
K6V22_RS06800	COG1620	l-lactate permease
K6V22_RS06805	COG3047	cAMP biosynthetic process
K6V22_RS06805	COG2885	chlorophyll binding
K6V22_RS06815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V22_RS06820	COG0439	Biotin carboxylase
K6V22_RS06825	COG0511	ligase activity, forming carbon-carbon bonds
K6V22_RS06830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6V22_RS06860	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6V22_RS06865	COG0022	dehydrogenase e1 component
K6V22_RS06870	COG0716	FMN binding
K6V22_RS06875	COG2264	protein methyltransferase activity
K6V22_RS06910	COG0590	tRNA wobble adenosine to inosine editing
K6V22_RS06935	COG0673	inositol 2-dehydrogenase activity
K6V22_RS06940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6V22_RS06980	COG0698	ribose 5-phosphate isomerase
K6V22_RS06985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6V22_RS06990	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6V22_RS07005	COG1482	cell wall glycoprotein biosynthetic process
K6V22_RS07025	COG0513	Belongs to the DEAD box helicase family
K6V22_RS07030	COG4221	oxidoreductase activity
K6V22_RS07045	COG3250	beta-galactosidase activity
K6V22_RS07055	COG3273	potassium ion transport
K6V22_RS07055	COG0471	metal ion transport
K6V22_RS07060	COG0529	Catalyzes the synthesis of activated sulfate
K6V22_RS07065	COG0175	sulfate reduction
K6V22_RS07110	COG4974	Belongs to the 'phage' integrase family
K6V22_RS07135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6V22_RS07140	COG0242	peptide deformylase activity
K6V22_RS07155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6V22_RS07160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K6V22_RS07165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6V22_RS07170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K6V22_RS07180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V22_RS07185	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V22_RS07200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6V22_RS07250	COG1940	carbohydrate kinase activity
K6V22_RS07255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6V22_RS07265	COG2271	Major facilitator Superfamily
K6V22_RS07270	COG2731	YhcH YjgK YiaL family protein
K6V22_RS07275	COG1629	transport
K6V22_RS07275	COG4206	TonB-dependent receptor
K6V22_RS07280	COG0702	epimerase
K6V22_RS07335	COG4771	TonB-dependent receptor
K6V22_RS07340	COG0702	epimerase
K6V22_RS07345	COG0702	epimerase
K6V22_RS07350	COG1629	transport
K6V22_RS07350	COG4206	TonB-dependent receptor
K6V22_RS07355	COG4206	TonB-dependent receptor
K6V22_RS07355	COG1629	transport
K6V22_RS07370	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS07390	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS07400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS07405	COG3537	Alpha-1,2-mannosidase
K6V22_RS07410	COG3250	beta-galactosidase activity
K6V22_RS07415	COG4206	TonB-dependent receptor
K6V22_RS07415	COG1629	transport
K6V22_RS07420	COG0702	epimerase
K6V22_RS07425	COG0484	heat shock protein binding
K6V22_RS07430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6V22_RS07435	COG0488	(ABC) transporter
K6V22_RS07440	COG1595	DNA-templated transcription, initiation
K6V22_RS07595	COG2885	chlorophyll binding
K6V22_RS07710	COG2183	response to ionizing radiation
K6V22_RS07720	COG0737	Belongs to the 5'-nucleotidase family
K6V22_RS07725	COG1956	GAF domain-containing protein
K6V22_RS07735	COG4771	TonB-dependent receptor
K6V22_RS07760	COG0534	Mate efflux family protein
K6V22_RS07770	COG0534	Mate efflux family protein
K6V22_RS07780	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K6V22_RS07790	COG0318	PFAM AMP-dependent synthetase and ligase
K6V22_RS07795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS07800	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K6V22_RS07840	COG4750	Nucleotidyl transferase
K6V22_RS07855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6V22_RS07885	COG1216	Glycosyl transferase, family 2
K6V22_RS07890	COG1216	Glycosyl transferase, family 2
K6V22_RS07905	COG1086	Polysaccharide biosynthesis protein
K6V22_RS07915	COG1091	dTDP-4-dehydrorhamnose reductase activity
K6V22_RS07925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS07930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V22_RS07955	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6V22_RS07960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6V22_RS07965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6V22_RS07970	COG0363	glucosamine-6-phosphate deaminase activity
K6V22_RS07990	COG4413	Urea transporter
K6V22_RS08020	COG3279	Response regulator of the LytR AlgR family
K6V22_RS08030	COG0577	efflux transmembrane transporter activity
K6V22_RS08030	COG1136	(ABC) transporter
K6V22_RS08035	COG1136	(ABC) transporter
K6V22_RS08040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V22_RS08065	COG3831	ATPase activity
K6V22_RS08065	COG4884	unkown
K6V22_RS08080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6V22_RS08090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V22_RS08095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6V22_RS08100	COG3250	beta-galactosidase activity
K6V22_RS08125	COG0501	Belongs to the peptidase M48B family
K6V22_RS08130	COG1704	LemA family
K6V22_RS08135	COG1595	DNA-templated transcription, initiation
K6V22_RS08145	COG4206	TonB-dependent receptor
K6V22_RS08145	COG1629	transport
K6V22_RS08155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6V22_RS08160	COG2885	chlorophyll binding
K6V22_RS08160	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V22_RS08170	COG0697	spore germination
K6V22_RS08215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V22_RS08230	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K6V22_RS08235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6V22_RS08240	COG2814	Major facilitator Superfamily
K6V22_RS08245	COG4771	TonB-dependent receptor
K6V22_RS08270	COG4771	TonB-dependent receptor
K6V22_RS08450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V22_RS08510	COG1196	nuclear chromosome segregation
K6V22_RS08510	COG0741	lytic transglycosylase activity
K6V22_RS08510	COG0739	heme binding
K6V22_RS08515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6V22_RS08565	COG3344	reverse transcriptase
K6V22_RS08605	COG3209	COG3209 Rhs family protein
K6V22_RS08615	COG3209	COG3209 Rhs family protein
K6V22_RS08680	COG0542	response to heat
K6V22_RS08735	COG0629	single-stranded DNA binding
K6V22_RS08740	COG1192	Involved in chromosome partitioning
K6V22_RS08755	COG1475	DNA binding
K6V22_RS08905	COG4974	Belongs to the 'phage' integrase family
K6V22_RS09070	COG0542	response to heat
K6V22_RS09095	COG0156	8-amino-7-oxononanoate synthase activity
K6V22_RS09170	COG0488	(ABC) transporter
K6V22_RS09190	COG2205	protein histidine kinase activity
K6V22_RS09190	COG2198	Histidine kinase
K6V22_RS09190	COG0784	Response regulator, receiver
K6V22_RS09190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V22_RS09210	COG0438	transferase activity, transferring glycosyl groups
K6V22_RS09215	COG2244	polysaccharide biosynthetic process
K6V22_RS09220	COG1442	glycosyl transferase family 8
K6V22_RS09220	COG1216	Glycosyl transferase, family 2
K6V22_RS09240	COG1215	transferase activity, transferring glycosyl groups
K6V22_RS09270	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V22_RS09275	COG1805	sodium ion transport
K6V22_RS09280	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V22_RS09305	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6V22_RS09310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6V22_RS09320	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V22_RS09325	COG1739	Uncharacterized protein family UPF0029
K6V22_RS09335	COG0778	Nitroreductase
K6V22_RS09340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V22_RS09340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V22_RS09345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6V22_RS09375	COG2217	Heavy metal translocating P-type atpase
K6V22_RS09410	COG3852	Histidine kinase
K6V22_RS09415	COG2204	response regulator
K6V22_RS09435	COG0577	efflux transmembrane transporter activity
K6V22_RS09435	COG1136	(ABC) transporter
K6V22_RS09450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6V22_RS09455	COG1755	Isoprenylcysteine carboxyl methyltransferase
K6V22_RS09465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6V22_RS09480	COG1678	Uncharacterized ACR, COG1678
K6V22_RS09500	COG0667	Aldo Keto reductase
K6V22_RS09510	COG0656	L-ascorbic acid biosynthetic process
K6V22_RS09520	COG0656	L-ascorbic acid biosynthetic process
K6V22_RS09525	COG0656	L-ascorbic acid biosynthetic process
K6V22_RS09540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6V22_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
K6V22_RS09575	COG1979	alcohol dehydrogenase
K6V22_RS09590	COG1028	Short-chain dehydrogenase reductase Sdr
K6V22_RS09595	COG0667	Aldo Keto reductase
K6V22_RS09610	COG2311	Membrane
K6V22_RS09615	COG0667	Aldo Keto reductase
K6V22_RS09680	COG4771	TonB-dependent receptor
K6V22_RS09705	COG1309	transcriptional regulator
K6V22_RS09720	COG1132	(ABC) transporter
K6V22_RS09725	COG4999	Histidine kinase
K6V22_RS09725	COG3850	Histidine kinase
K6V22_RS09725	COG2205	protein histidine kinase activity
K6V22_RS09725	COG3437	response regulator, receiver
K6V22_RS09740	COG1522	sequence-specific DNA binding
K6V22_RS09760	COG3969	phosphoadenosine phosphosulfate
K6V22_RS09765	COG1475	DNA binding
K6V22_RS09805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS09810	COG0745	RESPONSE REGULATOR receiver
K6V22_RS09825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS09835	COG4206	TonB-dependent receptor
K6V22_RS09835	COG1629	transport
K6V22_RS09900	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6V22_RS09920	COG1022	Amp-dependent synthetase and ligase
K6V22_RS09925	COG3263	regulation of cellular component size
K6V22_RS09970	COG1136	(ABC) transporter
K6V22_RS09970	COG0577	efflux transmembrane transporter activity
K6V22_RS09985	COG0534	Mate efflux family protein
K6V22_RS09990	COG1011	Hydrolase
K6V22_RS09995	COG0167	dihydroorotate dehydrogenase activity
K6V22_RS10005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6V22_RS10020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V22_RS10035	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6V22_RS10045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6V22_RS10055	COG0356	it plays a direct role in the translocation of protons across the membrane
K6V22_RS10060	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V22_RS10065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6V22_RS10070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V22_RS10075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6V22_RS10080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6V22_RS10085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V22_RS10090	COG3118	belongs to the thioredoxin family
K6V22_RS10110	COG0745	RESPONSE REGULATOR receiver
K6V22_RS10115	COG5002	protein histidine kinase activity
K6V22_RS10145	COG1120	ATPase activity
K6V22_RS10150	COG1091	dTDP-4-dehydrorhamnose reductase activity
K6V22_RS10180	COG2205	protein histidine kinase activity
K6V22_RS10185	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6V22_RS10195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6V22_RS10210	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6V22_RS10215	COG0540	Belongs to the ATCase OTCase family
K6V22_RS10225	COG2431	L-lysine efflux transmembrane transporter activity
K6V22_RS10250	COG2837	iron assimilation
K6V22_RS10260	COG4206	TonB-dependent receptor
K6V22_RS10260	COG1629	transport
K6V22_RS10280	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K6V22_RS10290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6V22_RS10310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6V22_RS10315	COG2205	protein histidine kinase activity
K6V22_RS10345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6V22_RS10350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6V22_RS10360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6V22_RS10370	COG0673	inositol 2-dehydrogenase activity
K6V22_RS10380	COG2223	nitrite transmembrane transporter activity
K6V22_RS10400	COG0671	phosphoesterase, PA-phosphatase related
K6V22_RS10415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K6V22_RS10420	COG0045	succinate-CoA ligase (ADP-forming) activity
K6V22_RS10425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6V22_RS10430	COG0351	phosphomethylpyrimidine kinase
K6V22_RS10440	COG1070	Carbohydrate kinase
K6V22_RS10450	COG2814	Major facilitator Superfamily
K6V22_RS10450	COG0477	Major facilitator Superfamily
K6V22_RS10460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V22_RS10460	COG3153	acetyltransferase
K6V22_RS10465	COG0450	alkyl hydroperoxide reductase
K6V22_RS10470	COG0724	RNA recognition motif
K6V22_RS10475	COG1858	cytochrome C peroxidase
K6V22_RS10480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V22_RS10510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K6V22_RS10520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6V22_RS10570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V22_RS10580	COG1904	glucuronate isomerase
K6V22_RS10610	COG0513	Belongs to the DEAD box helicase family
K6V22_RS10615	COG0560	Phosphoserine phosphatase
K6V22_RS10615	COG3830	Belongs to the UPF0237 family
K6V22_RS10630	COG0343	queuine tRNA-ribosyltransferase activity
K6V22_RS10635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6V22_RS10945	COG2205	protein histidine kinase activity
K6V22_RS10950	COG2204	response regulator
K6V22_RS10970	COG0577	efflux transmembrane transporter activity
K6V22_RS10970	COG1136	(ABC) transporter
K6V22_RS10995	COG1136	(ABC) transporter
K6V22_RS10995	COG0577	efflux transmembrane transporter activity
K6V22_RS11000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V22_RS11075	COG0156	8-amino-7-oxononanoate synthase activity
K6V22_RS11080	COG1597	lipid kinase activity
K6V22_RS11085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6V22_RS11110	COG0577	efflux transmembrane transporter activity
K6V22_RS11110	COG1136	(ABC) transporter
K6V22_RS11135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6V22_RS11165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V22_RS11180	COG0543	2 iron, 2 sulfur cluster binding
K6V22_RS11185	COG0167	dihydroorotate dehydrogenase activity
K6V22_RS11190	COG0336	Belongs to the RNA methyltransferase TrmD family
K6V22_RS11200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6V22_RS11210	COG2315	Protein conserved in bacteria
K6V22_RS11240	COG0326	Molecular chaperone. Has ATPase activity
K6V22_RS11245	COG0542	response to heat
K6V22_RS11290	COG2304	oxidoreductase activity
K6V22_RS11305	COG0714	Associated with various cellular activities
K6V22_RS11310	COG1652	LysM domain
K6V22_RS11320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V22_RS11325	COG0552	protein localization to endoplasmic reticulum
K6V22_RS11335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6V22_RS11340	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6V22_RS11350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6V22_RS11365	COG0442	prolyl-tRNA aminoacylation
K6V22_RS11375	COG0793	Belongs to the peptidase S41A family
K6V22_RS11375	COG4946	Tricorn protease homolog
K6V22_RS11385	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
K6V22_RS11390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6V22_RS11405	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K6V22_RS11415	COG1492	cobalamin metabolic process
K6V22_RS11460	COG2096	Adenosyltransferase
K6V22_RS11465	COG1797	cobyrinic acid a,c-diamide synthase activity
K6V22_RS11480	COG2966	Psort location CytoplasmicMembrane, score
K6V22_RS11495	COG4771	TonB-dependent receptor
K6V22_RS11505	COG4774	siderophore transport
K6V22_RS11515	COG1429	ligase activity, forming nitrogen-metal bonds
K6V22_RS11550	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K6V22_RS11620	COG0352	thiamine-phosphate diphosphorylase activity
K6V22_RS11625	COG2022	thiamine diphosphate biosynthetic process
K6V22_RS11630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6V22_RS11650	COG0352	thiamine-phosphate diphosphorylase activity
K6V22_RS11665	COG0574	Belongs to the PEP-utilizing enzyme family
K6V22_RS11665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6V22_RS11670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6V22_RS11675	COG0564	pseudouridine synthase activity
K6V22_RS11690	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K6V22_RS11710	COG0024	Methionine aminopeptidase
K6V22_RS11725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6V22_RS11735	COG0481	GTPase activity
K6V22_RS11755	COG0708	Exodeoxyribonuclease III
K6V22_RS11760	COG1914	H( )-stimulated, divalent metal cation uptake system
K6V22_RS11775	COG0217	transcriptional regulatory protein
K6V22_RS11780	COG0072	phenylalanine-tRNA ligase activity
K6V22_RS11780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6V22_RS11785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V22_RS11790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS11800	COG1091	dTDP-4-dehydrorhamnose reductase activity
K6V22_RS11810	COG1086	Polysaccharide biosynthesis protein
K6V22_RS11815	COG0463	Glycosyl transferase, family 2
K6V22_RS11820	COG1216	Glycosyl transferase, family 2
K6V22_RS11820	COG0463	Glycosyl transferase, family 2
K6V22_RS11840	COG1454	alcohol dehydrogenase
K6V22_RS11855	COG3475	LICD family
K6V22_RS11870	COG2244	polysaccharide biosynthetic process
K6V22_RS11900	COG0305	Participates in initiation and elongation during chromosome replication
K6V22_RS11905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6V22_RS11920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6V22_RS11925	COG4657	Part of a membrane complex involved in electron transport
K6V22_RS11930	COG4660	Part of a membrane complex involved in electron transport
K6V22_RS11935	COG4659	FMN binding
K6V22_RS11940	COG4658	electron transport chain
K6V22_RS11945	COG4656	Part of a membrane complex involved in electron transport
K6V22_RS11970	COG0504	CTP synthase activity
K6V22_RS11980	COG0534	Mate efflux family protein
K6V22_RS11985	COG1506	peptidase
K6V22_RS11985	COG0823	Involved in the tonB-independent uptake of proteins
K6V22_RS12000	COG1695	Transcriptional regulator
K6V22_RS12015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6V22_RS12025	COG1388	LysM domain
K6V22_RS12025	COG3942	CHAP domain
K6V22_RS12055	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V22_RS12060	COG0556	nucleotide-excision repair
K6V22_RS12065	COG2949	membrane
K6V22_RS12075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6V22_RS12085	COG2205	protein histidine kinase activity
K6V22_RS12085	COG4999	Histidine kinase
K6V22_RS12085	COG3850	Histidine kinase
K6V22_RS12085	COG3437	response regulator, receiver
K6V22_RS12095	COG0842	Transport permease protein
K6V22_RS12100	COG1131	(ABC) transporter
K6V22_RS12130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V22_RS12135	COG0505	Belongs to the CarA family
K6V22_RS12155	COG0367	asparagine synthase
K6V22_RS12190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6V22_RS12200	COG1979	alcohol dehydrogenase
K6V22_RS12205	COG0133	tryptophan synthase activity
K6V22_RS12210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6V22_RS12215	COG0512	Glutamine amidotransferase of anthranilate synthase
K6V22_RS12215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6V22_RS12225	COG0134	indole-3-glycerol-phosphate synthase activity
K6V22_RS12230	COG0135	phosphoribosylanthranilate isomerase activity
K6V22_RS12235	COG0159	tryptophan synthase activity
K6V22_RS12240	COG0252	asparaginase activity
K6V22_RS12255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V22_RS12265	COG0110	maltose O-acetyltransferase activity
K6V22_RS12270	COG2197	response regulator
K6V22_RS12280	COG0138	bifunctional purine biosynthesis protein purh
K6V22_RS12285	COG0716	FMN binding
K6V22_RS12310	COG1858	cytochrome C peroxidase
K6V22_RS12320	COG4771	TonB-dependent receptor
K6V22_RS12335	COG2814	Major facilitator Superfamily
K6V22_RS12340	COG1566	PFAM secretion protein HlyD family protein
K6V22_RS12370	COG4771	TonB-dependent receptor
K6V22_RS12395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6V22_RS12400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6V22_RS12410	COG2966	Psort location CytoplasmicMembrane, score
K6V22_RS12415	COG3610	response to peptide
K6V22_RS12430	COG1609	Transcriptional regulator
K6V22_RS12440	COG1733	regulation of RNA biosynthetic process
K6V22_RS12445	COG2205	protein histidine kinase activity
K6V22_RS12445	COG0784	Response regulator, receiver
K6V22_RS12445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V22_RS12445	COG2198	Histidine kinase
K6V22_RS12460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K6V22_RS12465	COG1690	Belongs to the RtcB family
K6V22_RS12485	COG0228	four-way junction DNA binding
K6V22_RS12500	COG0724	RNA recognition motif
K6V22_RS12510	COG1177	transmembrane transport
K6V22_RS12515	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6V22_RS12525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V22_RS12535	COG0058	SHG alpha-glucan phosphorylase activity
K6V22_RS12545	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V22_RS12565	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K6V22_RS12610	COG0745	RESPONSE REGULATOR receiver
K6V22_RS12615	COG5002	protein histidine kinase activity
K6V22_RS12640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6V22_RS12645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V22_RS12655	COG4948	Mandelate Racemase Muconate Lactonizing
K6V22_RS12670	COG1295	ribonuclease BN
K6V22_RS12675	COG0778	Nitroreductase
K6V22_RS12685	COG0704	Plays a role in the regulation of phosphate uptake
K6V22_RS12690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6V22_RS12695	COG0581	inorganic phosphate transmembrane transporter activity
K6V22_RS12700	COG0573	inorganic phosphate transmembrane transporter activity
K6V22_RS12710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V22_RS12730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6V22_RS12765	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V22_RS12795	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6V22_RS12800	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K6V22_RS12825	COG1216	Glycosyl transferase, family 2
K6V22_RS12825	COG1442	glycosyl transferase family 8
K6V22_RS12840	COG1216	Glycosyl transferase, family 2
K6V22_RS12875	COG0438	transferase activity, transferring glycosyl groups
K6V22_RS12885	COG0562	UDP-galactopyranose mutase
K6V22_RS12890	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K6V22_RS12940	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6V22_RS12975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6V22_RS12980	COG0167	dihydroorotate dehydrogenase activity
K6V22_RS13130	COG4771	TonB-dependent receptor
K6V22_RS13135	COG0702	epimerase
K6V22_RS13160	COG3392	D12 class N6 adenine-specific DNA methyltransferase
K6V22_RS13170	COG1192	Involved in chromosome partitioning
K6V22_RS13385	COG5002	protein histidine kinase activity
K6V22_RS13400	COG2172	sigma factor antagonist activity
K6V22_RS13410	COG2208	phosphoserine phosphatase activity
K6V22_RS13435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6V22_RS13455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6V22_RS13460	COG0497	DNA recombination
K6V22_RS13470	COG2176	DNA-directed DNA polymerase activity
K6V22_RS13470	COG5002	protein histidine kinase activity
K6V22_RS13475	COG0592	DNA-directed DNA polymerase activity
K6V22_RS13490	COG0321	lipoyl(octanoyl) transferase activity
K6V22_RS13490	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V22_RS13505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS13510	COG0156	8-amino-7-oxononanoate synthase activity
K6V22_RS13620	COG0019	diaminopimelate decarboxylase activity
K6V22_RS13625	COG0527	aspartate kinase activity
K6V22_RS13630	COG2884	Cell division ATP-binding protein ftsE
K6V22_RS13635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6V22_RS13635	COG0140	phosphoribosyl-ATP diphosphatase activity
K6V22_RS13645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6V22_RS13665	COG3586	endonuclease activity
K6V22_RS13695	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V22_RS13700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6V22_RS13710	COG5012	cobalamin binding
K6V22_RS13720	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V22_RS13725	COG0702	epimerase
K6V22_RS13730	COG4771	TonB-dependent receptor
K6V22_RS13750	COG0693	protein deglycase activity
K6V22_RS13760	COG0494	nUDIX hydrolase
K6V22_RS13765	COG1401	restriction endodeoxyribonuclease activity
K6V22_RS13780	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K6V22_RS13820	COG1917	Cupin 2, conserved barrel domain protein
K6V22_RS13820	COG4977	sequence-specific DNA binding
K6V22_RS13825	COG2814	Major facilitator Superfamily
K6V22_RS13830	COG1028	Short-chain dehydrogenase reductase Sdr
K6V22_RS13835	COG2207	Transcriptional regulator
K6V22_RS13850	COG1090	epimerase
K6V22_RS13880	COG0561	phosphatase activity
K6V22_RS13885	COG4206	TonB-dependent receptor
K6V22_RS13885	COG1629	transport
K6V22_RS13935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V22_RS13945	COG0363	glucosamine-6-phosphate deaminase activity
K6V22_RS13985	COG1032	radical SAM domain protein
K6V22_RS13990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6V22_RS13995	COG0463	Glycosyl transferase, family 2
K6V22_RS14000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6V22_RS14010	COG0646	methionine synthase
K6V22_RS14010	COG1410	methionine synthase
K6V22_RS14055	COG1408	metallophosphoesterase
K6V22_RS14060	COG1132	(ABC) transporter
K6V22_RS14065	COG1132	(ABC) transporter
K6V22_RS14080	COG0420	3'-5' exonuclease activity
K6V22_RS14100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6V22_RS14105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V22_RS14115	COG0681	Belongs to the peptidase S26 family
K6V22_RS14210	COG0641	radical SAM
K6V22_RS14215	COG3591	Belongs to the peptidase S1B family
K6V22_RS14220	COG3591	Belongs to the peptidase S1B family
K6V22_RS14255	COG1592	Rubrerythrin
K6V22_RS14255	COG1773	rubredoxin
K6V22_RS14265	COG3152	Membrane
K6V22_RS14270	COG0339	signal peptide processing
K6V22_RS14275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6V22_RS14275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V22_RS14285	COG1629	transport
K6V22_RS14285	COG4206	TonB-dependent receptor
K6V22_RS14300	COG0131	Imidazoleglycerol-phosphate dehydratase
K6V22_RS14300	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6V22_RS14305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6V22_RS14310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6V22_RS14315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6V22_RS14325	COG1741	Belongs to the pirin family
K6V22_RS14330	COG4232	protein-disulfide reductase activity
K6V22_RS14340	COG0572	uridine kinase
K6V22_RS14350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6V22_RS14360	COG0646	methionine synthase
K6V22_RS14360	COG1410	methionine synthase
K6V22_RS14365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6V22_RS14400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V22_RS14435	COG2205	protein histidine kinase activity
K6V22_RS14435	COG2202	Pas domain
K6V22_RS14440	COG0534	Mate efflux family protein
K6V22_RS14445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6V22_RS14450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V22_RS14455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6V22_RS14460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V22_RS14520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6V22_RS14560	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V22_RS14570	COG0668	transmembrane transport
K6V22_RS14585	COG3250	beta-galactosidase activity
K6V22_RS14590	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS14595	COG3119	arylsulfatase activity
K6V22_RS14600	COG3119	arylsulfatase activity
K6V22_RS14605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS14610	COG0745	RESPONSE REGULATOR receiver
K6V22_RS14610	COG3292	Two component regulator propeller
K6V22_RS14610	COG2205	protein histidine kinase activity
K6V22_RS14615	COG1830	Aldolase
K6V22_RS14620	COG0588	phosphoglycerate mutase activity
K6V22_RS14630	COG1119	ATPase activity
K6V22_RS14635	COG3119	arylsulfatase activity
K6V22_RS14640	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS14650	COG1629	transport
K6V22_RS14650	COG4206	TonB-dependent receptor
K6V22_RS14660	COG1595	DNA-templated transcription, initiation
K6V22_RS14665	COG1523	belongs to the glycosyl hydrolase 13 family
K6V22_RS14670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6V22_RS14690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6V22_RS14700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6V22_RS14705	COG0126	phosphoglycerate kinase activity
K6V22_RS14720	COG2311	Membrane
K6V22_RS14770	COG0424	maF-like protein
K6V22_RS14775	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K6V22_RS14790	COG0778	Nitroreductase
K6V22_RS14795	COG0288	reversible hydration of carbon dioxide
K6V22_RS14810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V22_RS14820	COG5016	pyruvate
K6V22_RS14820	COG0511	ligase activity, forming carbon-carbon bonds
K6V22_RS14825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6V22_RS14840	COG0366	Alpha amylase catalytic
K6V22_RS14860	COG0191	fructose-bisphosphate aldolase activity
K6V22_RS14870	COG0254	rRNA binding
K6V22_RS14890	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V22_RS14895	COG1629	transport
K6V22_RS14895	COG4206	TonB-dependent receptor
K6V22_RS14900	COG1609	Transcriptional regulator
K6V22_RS14910	COG1554	hydrolase, family 65, central catalytic
K6V22_RS14915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V22_RS14935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6V22_RS14935	COG0047	phosphoribosylformylglycinamidine synthase activity
K6V22_RS14940	COG3292	Two component regulator propeller
K6V22_RS14940	COG0745	RESPONSE REGULATOR receiver
K6V22_RS14940	COG2205	protein histidine kinase activity
K6V22_RS14955	COG1649	PFAM Uncharacterised BCR, COG1649
K6V22_RS14975	COG1966	Carbon starvation protein
K6V22_RS14980	COG1649	PFAM Uncharacterised BCR, COG1649
K6V22_RS14985	COG0784	Response regulator, receiver
K6V22_RS14985	COG2205	protein histidine kinase activity
K6V22_RS15020	COG4176	ABC-type proline glycine betaine transport system permease component
K6V22_RS15035	COG0745	RESPONSE REGULATOR receiver
K6V22_RS15035	COG2205	protein histidine kinase activity
K6V22_RS15035	COG3292	Two component regulator propeller
K6V22_RS15040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6V22_RS15040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6V22_RS15050	COG1621	beta-fructofuranosidase activity
K6V22_RS15090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K6V22_RS15110	COG0738	Major facilitator superfamily
K6V22_RS15125	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6V22_RS15130	COG0475	glutathione-regulated potassium exporter activity
K6V22_RS15155	COG3015	lipoprotein NlpE involved in copper resistance
K6V22_RS15175	COG1917	Cupin 2, conserved barrel domain protein
K6V22_RS15175	COG4977	sequence-specific DNA binding
K6V22_RS15200	COG4771	TonB-dependent receptor
K6V22_RS15205	COG0702	epimerase
K6V22_RS15220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6V22_RS15240	COG0484	heat shock protein binding
K6V22_RS15250	COG2194	sulfuric ester hydrolase activity
K6V22_RS15290	COG0028	Belongs to the TPP enzyme family
K6V22_RS15320	COG0459	protein refolding
K6V22_RS15325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6V22_RS15365	COG2326	polyphosphate kinase activity
K6V22_RS15400	COG3537	Alpha-1,2-mannosidase
K6V22_RS15405	COG1506	peptidase
K6V22_RS15405	COG0823	Involved in the tonB-independent uptake of proteins
K6V22_RS15435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6V22_RS15475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6V22_RS15485	COG0671	phosphoesterase, PA-phosphatase related
K6V22_RS15500	COG0702	epimerase
K6V22_RS15505	COG4771	TonB-dependent receptor
K6V22_RS15525	COG0463	Glycosyl transferase, family 2
K6V22_RS15540	COG0066	3-isopropylmalate dehydratase activity
K6V22_RS15545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6V22_RS15550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6V22_RS15590	COG0616	signal peptide processing
K6V22_RS15595	COG1663	tetraacyldisaccharide 4'-kinase activity
K6V22_RS15600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6V22_RS15605	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6V22_RS15615	COG4974	Belongs to the 'phage' integrase family
K6V22_RS15680	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6V22_RS15705	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K6V22_RS15730	COG3708	Transcriptional regulator
K6V22_RS15730	COG2207	Transcriptional regulator
K6V22_RS15750	COG0546	phosphoglycolate phosphatase activity
K6V22_RS15765	COG2207	Transcriptional regulator
K6V22_RS15770	COG3292	Two component regulator propeller
K6V22_RS15770	COG0745	RESPONSE REGULATOR receiver
K6V22_RS15770	COG2205	protein histidine kinase activity
K6V22_RS15775	COG4948	Mandelate Racemase Muconate Lactonizing
K6V22_RS15795	COG0702	epimerase
K6V22_RS15800	COG4206	TonB-dependent receptor
K6V22_RS15800	COG1629	transport
K6V22_RS15825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6V22_RS15830	COG2207	Transcriptional regulator
K6V22_RS15830	COG1917	Cupin 2, conserved barrel domain protein
K6V22_RS15845	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
K6V22_RS15855	COG3011	Protein conserved in bacteria
K6V22_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
K6V22_RS15925	COG0358	DNA primase activity
K6V22_RS15980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6V22_RS15990	COG4651	solute:proton antiporter activity
K6V22_RS15990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6V22_RS15995	COG0439	Biotin carboxylase
K6V22_RS16000	COG5016	pyruvate
K6V22_RS16000	COG0511	ligase activity, forming carbon-carbon bonds
K6V22_RS16005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V22_RS16010	COG1335	isochorismatase
K6V22_RS16020	COG0516	GMP reductase activity
K6V22_RS16020	COG0517	IMP dehydrogenase activity
K6V22_RS16035	COG2207	Transcriptional regulator
K6V22_RS16040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V22_RS16055	COG2873	o-acetylhomoserine
K6V22_RS16125	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6V22_RS16135	COG0741	lytic transglycosylase activity
K6V22_RS16135	COG1388	LysM domain
K6V22_RS16140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6V22_RS16145	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K6V22_RS16145	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K6V22_RS16155	COG1285	pathogenesis
K6V22_RS16175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6V22_RS16175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6V22_RS16190	COG1115	amino acid carrier protein
K6V22_RS16200	COG1509	lysine 2,3-aminomutase activity
K6V22_RS16205	COG2233	PERMEase
K6V22_RS16220	COG1393	Belongs to the ArsC family
K6V22_RS16230	COG1629	transport
K6V22_RS16240	COG2304	oxidoreductase activity
K6V22_RS16250	COG0351	phosphomethylpyrimidine kinase
K6V22_RS16260	COG1139	Iron-sulfur cluster binding protein
K6V22_RS16265	COG0247	lactate metabolic process
K6V22_RS16270	COG0602	queuosine metabolic process
K6V22_RS16280	COG2832	Protein of unknown function (DUF454)
K6V22_RS16285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V22_RS16300	COG3142	Participates in the control of copper homeostasis
K6V22_RS16305	COG1418	mRNA catabolic process
K6V22_RS16330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6V22_RS16345	COG4771	TonB-dependent receptor
K6V22_RS16400	COG3340	Belongs to the peptidase S51 family
K6V22_RS16405	COG2378	regulation of single-species biofilm formation
K6V22_RS16455	COG1505	serine-type exopeptidase activity
K6V22_RS16480	COG0517	IMP dehydrogenase activity
K6V22_RS16480	COG0617	tRNA 3'-terminal CCA addition
K6V22_RS16480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6V22_RS16505	COG0612	Peptidase, M16
K6V22_RS16515	COG1278	Cold shock
K6V22_RS16545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS16550	COG1216	Glycosyl transferase, family 2
K6V22_RS16575	COG1215	transferase activity, transferring glycosyl groups
K6V22_RS16590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V22_RS16605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K6V22_RS16615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V22_RS16660	COG0776	regulation of translation
K6V22_RS16670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6V22_RS16705	COG0632	four-way junction helicase activity
K6V22_RS16710	COG0673	inositol 2-dehydrogenase activity
K6V22_RS16715	COG1272	protein, Hemolysin III
K6V22_RS16720	COG1328	CTP reductase activity
K6V22_RS16730	COG2814	Major facilitator Superfamily
K6V22_RS16740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V22_RS16750	COG0750	zinc metalloprotease
K6V22_RS16765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6V22_RS16770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6V22_RS16780	COG1214	PFAM Peptidase M22, glycoprotease
K6V22_RS16790	COG0194	GDP metabolic process
K6V22_RS16795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6V22_RS16800	COG1408	metallophosphoesterase
K6V22_RS16805	COG1575	Belongs to the MenA family. Type 1 subfamily
K6V22_RS16810	COG1088	dTDP-glucose 4,6-dehydratase activity
K6V22_RS16815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6V22_RS16825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6V22_RS16835	COG2204	response regulator
K6V22_RS16840	COG0488	(ABC) transporter
K6V22_RS16910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6V22_RS16920	COG1522	sequence-specific DNA binding
K6V22_RS16945	COG0811	peptide transport
K6V22_RS16955	COG0084	hydrolase, TatD family'
K6V22_RS16970	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6V22_RS16975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6V22_RS16980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6V22_RS16985	COG0205	6-phosphofructokinase activity
K6V22_RS17005	COG0372	Belongs to the citrate synthase family
K6V22_RS17010	COG0538	isocitrate dehydrogenase activity
K6V22_RS17020	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K6V22_RS17030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6V22_RS17055	COG0129	dihydroxy-acid dehydratase activity
K6V22_RS17080	COG2885	chlorophyll binding
K6V22_RS17100	COG3681	Belongs to the UPF0597 family
K6V22_RS17135	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6V22_RS17145	COG0702	epimerase
K6V22_RS17150	COG4771	TonB-dependent receptor
K6V22_RS17165	COG0702	epimerase
K6V22_RS17170	COG4206	TonB-dependent receptor
K6V22_RS17170	COG1629	transport
K6V22_RS17175	COG3291	Pkd domain containing protein
K6V22_RS17175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS17185	COG4771	TonB-dependent receptor
K6V22_RS17200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6V22_RS17240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V22_RS17240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V22_RS17245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V22_RS17280	COG0534	Mate efflux family protein
K6V22_RS17285	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6V22_RS17290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6V22_RS17295	COG0166	Belongs to the GPI family
K6V22_RS17305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V22_RS17315	COG2502	aspartate--ammonia ligase
K6V22_RS17320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6V22_RS17335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS17350	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6V22_RS17360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6V22_RS17375	COG1640	4-alpha-glucanotransferase
K6V22_RS17385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6V22_RS17390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V22_RS17410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V22_RS17415	COG1022	Amp-dependent synthetase and ligase
K6V22_RS17425	COG0359	binds to the 23S rRNA
K6V22_RS17430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6V22_RS17435	COG0360	Binds together with S18 to 16S ribosomal RNA
K6V22_RS17460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V22_RS17465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6V22_RS17485	COG4771	TonB-dependent receptor
K6V22_RS17500	COG2431	L-lysine efflux transmembrane transporter activity
K6V22_RS17525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V22_RS17530	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K6V22_RS17535	COG0386	Belongs to the glutathione peroxidase family
K6V22_RS17555	COG3275	phosphorelay sensor kinase activity
K6V22_RS17560	COG3279	Response regulator of the LytR AlgR family
K6V22_RS17580	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6V22_RS17595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V22_RS17605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6V22_RS17610	COG0658	competence protein
K6V22_RS17615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6V22_RS17620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6V22_RS17630	COG0009	L-threonylcarbamoyladenylate synthase
K6V22_RS17685	COG0438	transferase activity, transferring glycosyl groups
K6V22_RS17695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V22_RS17710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V22_RS17725	COG0438	transferase activity, transferring glycosyl groups
K6V22_RS17730	COG1045	serine acetyltransferase
K6V22_RS17740	COG0438	transferase activity, transferring glycosyl groups
K6V22_RS17790	COG2818	Glycosylase
K6V22_RS17835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6V22_RS17835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K6V22_RS17840	COG0514	ATP-dependent DNA helicase (RecQ)
K6V22_RS17850	COG2271	Major facilitator Superfamily
K6V22_RS17865	COG0702	epimerase
K6V22_RS17870	COG4771	TonB-dependent receptor
K6V22_RS17875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6V22_RS17880	COG2186	Transcriptional regulator
K6V22_RS17890	COG0436	Aminotransferase
K6V22_RS17895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K6V22_RS17905	COG0358	DNA primase activity
K6V22_RS17910	COG3119	arylsulfatase activity
K6V22_RS17925	COG1629	transport
K6V22_RS17925	COG4206	TonB-dependent receptor
K6V22_RS17940	COG0302	gtp cyclohydrolase
K6V22_RS17950	COG0149	triose-phosphate isomerase activity
K6V22_RS17965	COG0739	heme binding
K6V22_RS17970	COG0105	UTP biosynthetic process
K6V22_RS17975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6V22_RS17980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6V22_RS18000	COG0811	peptide transport
K6V22_RS18010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6V22_RS18040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6V22_RS18045	COG0470	DNA polymerase III
K6V22_RS18050	COG1774	PSP1 C-terminal conserved region
K6V22_RS18060	COG0772	Belongs to the SEDS family
K6V22_RS18075	COG1792	Involved in formation and maintenance of cell shape
K6V22_RS18085	COG0138	bifunctional purine biosynthesis protein purh
K6V22_RS18090	COG3590	peptidase
K6V22_RS18095	COG0488	(ABC) transporter
K6V22_RS18120	COG2205	protein histidine kinase activity
K6V22_RS18120	COG0784	Response regulator, receiver
K6V22_RS18125	COG0534	Mate efflux family protein
K6V22_RS18130	COG0612	Peptidase, M16
K6V22_RS18150	COG0564	pseudouridine synthase activity
K6V22_RS18185	COG2312	Erythromycin esterase
K6V22_RS18205	COG1131	(ABC) transporter
K6V22_RS18285	COG1629	transport
K6V22_RS18320	COG0039	L-malate dehydrogenase activity
K6V22_RS18350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V22_RS18365	COG4948	Mandelate Racemase Muconate Lactonizing
K6V22_RS18385	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6V22_RS18390	COG3118	belongs to the thioredoxin family
K6V22_RS18395	COG0489	protein tyrosine kinase activity
K6V22_RS18410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6V22_RS18415	COG1722	exodeoxyribonuclease VII activity
K6V22_RS18420	COG1570	exodeoxyribonuclease VII activity
K6V22_RS18430	COG0482	sulfurtransferase activity
K6V22_RS18455	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6V22_RS18460	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K6V22_RS18470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6V22_RS18475	COG0052	Belongs to the universal ribosomal protein uS2 family
K6V22_RS18480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6V22_RS18485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6V22_RS18495	COG0017	Asparaginyl-tRNA synthetase
K6V22_RS18500	COG1187	pseudouridine synthase activity
K6V22_RS18530	COG0110	maltose O-acetyltransferase activity
K6V22_RS18535	COG3022	response to hydroperoxide
K6V22_RS18540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V22_RS18595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V22_RS18630	COG1442	glycosyl transferase family 8
K6V22_RS18630	COG1216	Glycosyl transferase, family 2
K6V22_RS18655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6V22_RS18685	COG0297	glycogen (starch) synthase activity
K6V22_RS18745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6V22_RS18760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6V22_RS18775	COG0516	GMP reductase activity
K6V22_RS18775	COG0517	IMP dehydrogenase activity
K6V22_RS18780	COG0514	ATP-dependent DNA helicase (RecQ)
K6V22_RS18785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6V22_RS18795	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6V22_RS18800	COG0724	RNA recognition motif
K6V22_RS18810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6V22_RS18815	COG1127	ABC transporter
K6V22_RS18820	COG2197	response regulator
K6V22_RS18825	COG1160	GTP binding
K6V22_RS18830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6V22_RS18835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V22_RS18875	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K6V22_RS18890	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
K6V22_RS18910	COG1696	Membrane protein involved in D-alanine export
K6V22_RS18950	COG2986	histidine ammonia-lyase
K6V22_RS18960	COG1228	amidohydrolase
K6V22_RS18970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6V22_RS18995	COG0203	ribosomal protein L17
K6V22_RS19000	COG0202	RNA polymerase activity
K6V22_RS19005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6V22_RS19010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6V22_RS19015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6V22_RS19020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6V22_RS19025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6V22_RS19040	COG0200	Binds to the 23S rRNA
K6V22_RS19045	COG1841	ribosomal large subunit assembly
K6V22_RS19050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6V22_RS19055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6V22_RS19060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6V22_RS19065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6V22_RS19070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6V22_RS19075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6V22_RS19080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6V22_RS19085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6V22_RS19090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6V22_RS19095	COG0255	Belongs to the universal ribosomal protein uL29 family
K6V22_RS19100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6V22_RS19105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6V22_RS19110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6V22_RS19115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6V22_RS19120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6V22_RS19125	COG0089	rRNA binding
K6V22_RS19130	COG0088	Forms part of the polypeptide exit tunnel
K6V22_RS19135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6V22_RS19140	COG0051	transcription antitermination factor activity, RNA binding
K6V22_RS19145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V22_RS19150	COG0049	tRNA binding
K6V22_RS19155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K6V22_RS19190	COG0085	RNA polymerase activity
K6V22_RS19195	COG0222	ribosome binding
K6V22_RS19200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6V22_RS19205	COG0081	regulation of translation
K6V22_RS19210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6V22_RS19255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6V22_RS19260	COG4974	Belongs to the 'phage' integrase family
K6V22_RS19265	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6V22_RS19275	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6V22_RS19285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V22_RS19290	COG1480	7TM receptor with intracellular HD hydrolase
K6V22_RS19295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6V22_RS19305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6V22_RS19325	COG1027	Aspartate ammonia-lyase
K6V22_RS19330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6V22_RS19335	COG0252	asparaginase activity
K6V22_RS19350	COG2096	Adenosyltransferase
K6V22_RS19400	COG2755	lipolytic protein G-D-S-L family
K6V22_RS19400	COG0657	acetylesterase activity
K6V22_RS19415	COG3279	Response regulator of the LytR AlgR family
K6V22_RS19430	COG4771	TonB-dependent receptor
K6V22_RS19450	COG2197	response regulator
K6V22_RS19465	COG2207	Transcriptional regulator
K6V22_RS19465	COG0662	Cupin 2, conserved barrel domain protein
K6V22_RS19470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6V22_RS19500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6V22_RS19525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6V22_RS19535	COG1185	polyribonucleotide nucleotidyltransferase activity
K6V22_RS19550	COG4771	TonB-dependent receptor
K6V22_RS19575	COG3426	butyrate kinase activity
K6V22_RS19580	COG0280	phosphate acetyltransferase
K6V22_RS19590	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6V22_RS19595	COG2234	aminopeptidase activity
K6V22_RS19600	COG2166	iron-sulfur cluster assembly
K6V22_RS19605	COG3655	Transcriptional regulator
K6V22_RS19615	COG1266	CAAX protease self-immunity
K6V22_RS19620	COG0196	riboflavin kinase activity
K6V22_RS19625	COG1011	Hydrolase
K6V22_RS19630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6V22_RS19635	COG2205	protein histidine kinase activity
K6V22_RS19635	COG0784	Response regulator, receiver
K6V22_RS19640	COG1773	rubredoxin
K6V22_RS19645	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6V22_RS19655	COG2205	protein histidine kinase activity
K6V22_RS19680	COG0006	proline dipeptidase activity
K6V22_RS19695	COG0509	glycine decarboxylation via glycine cleavage system
K6V22_RS19700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6V22_RS19725	COG0702	epimerase
K6V22_RS19730	COG4771	TonB-dependent receptor
K6V22_RS19745	COG0793	Belongs to the peptidase S41A family
K6V22_RS19750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6V22_RS19785	COG4771	TonB-dependent receptor
K6V22_RS19795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6V22_RS19800	COG1882	Formate acetyltransferase
K6V22_RS19805	COG2814	Major facilitator Superfamily
K6V22_RS19805	COG0477	Major facilitator Superfamily
K6V22_RS19825	COG1040	competence protein
K6V22_RS19830	COG0483	inositol monophosphate 1-phosphatase activity
K6V22_RS19840	COG3345	alpha-galactosidase
K6V22_RS19865	COG3475	LICD family
K6V22_RS19870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6V22_RS19900	COG1442	glycosyl transferase family 8
K6V22_RS20005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6V22_RS20010	COG0776	regulation of translation
K6V22_RS20045	COG1609	Transcriptional regulator
K6V22_RS20045	COG2207	Transcriptional regulator
K6V22_RS20060	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6V22_RS20060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6V22_RS20065	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6V22_RS20075	COG0584	glycerophosphoryl diester phosphodiesterase
K6V22_RS20080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6V22_RS20085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6V22_RS20090	COG1629	transport
K6V22_RS20100	COG1629	transport
K6V22_RS20115	COG5434	Belongs to the glycosyl hydrolase 28 family
K6V22_RS20140	COG1629	transport
K6V22_RS20150	COG1217	gtp-binding protein TYPA
K6V22_RS20155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6V22_RS20165	COG0318	PFAM AMP-dependent synthetase and ligase
K6V22_RS20170	COG5002	protein histidine kinase activity
K6V22_RS20170	COG2205	protein histidine kinase activity
K6V22_RS20170	COG0784	Response regulator, receiver
K6V22_RS20185	COG3119	arylsulfatase activity
K6V22_RS20195	COG4206	TonB-dependent receptor
K6V22_RS20195	COG1629	transport
K6V22_RS20210	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6V22_RS20215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6V22_RS20230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6V22_RS20235	COG4974	Belongs to the 'phage' integrase family
K6V22_RS20245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V22_RS20250	COG0606	chelatase, subunit chli
K6V22_RS20270	COG0745	RESPONSE REGULATOR receiver
K6V22_RS20270	COG2205	protein histidine kinase activity
K6V22_RS20270	COG3292	Two component regulator propeller
K6V22_RS20355	COG0438	transferase activity, transferring glycosyl groups
K6V22_RS20380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6V22_RS20385	COG0438	transferase activity, transferring glycosyl groups
K6V22_RS20395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6V22_RS20400	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V22_RS20405	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V22_RS20410	COG1522	sequence-specific DNA binding
K6V22_RS20430	COG3275	phosphorelay sensor kinase activity
K6V22_RS20495	COG1629	transport
K6V22_RS20495	COG4206	TonB-dependent receptor
K6V22_RS20505	COG2814	Major facilitator Superfamily
K6V22_RS20525	COG0745	RESPONSE REGULATOR receiver
K6V22_RS20525	COG2205	protein histidine kinase activity
K6V22_RS20525	COG3292	Two component regulator propeller
K6V22_RS20565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6V22_RS20570	COG3409	Peptidoglycan-binding domain 1 protein
K6V22_RS20570	COG0793	Belongs to the peptidase S41A family
K6V22_RS20590	COG1053	succinate dehydrogenase
K6V22_RS20595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6V22_RS20610	COG4771	TonB-dependent receptor
K6V22_RS20635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6V22_RS20635	COG0758	DNA mediated transformation
K6V22_RS20645	COG0826	peptidase U32
K6V22_RS20655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6V22_RS20670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6V22_RS20675	COG0557	exoribonuclease II activity
K6V22_RS20695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6V22_RS20710	COG0012	GTP binding
K6V22_RS20715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6V22_RS20720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6V22_RS20730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V22_RS20740	COG0495	leucyl-tRNA aminoacylation
K6V22_RS20745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6V22_RS20755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6V22_RS20775	COG1215	transferase activity, transferring glycosyl groups
K6V22_RS20825	COG0731	radical SAM domain protein
K6V22_RS20825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V22_RS20850	COG0659	secondary active sulfate transmembrane transporter activity
K6V22_RS20855	COG1592	Rubrerythrin
K6V22_RS20860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6V22_RS20880	COG0427	acetyl-CoA hydrolase
K6V22_RS20890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V22_RS20900	COG3250	beta-galactosidase activity
K6V22_RS21045	COG2177	Part of the ABC transporter FtsEX involved in
K6V22_RS21055	COG1968	undecaprenyl-diphosphatase activity
K6V22_RS21060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6V22_RS21065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V22_RS21070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6V22_RS21080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6V22_RS21085	COG1611	Belongs to the LOG family
K6V22_RS21100	COG0594	ribonuclease P activity
K6V22_RS21105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K6V22_RS21115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6V22_RS21120	COG4946	Tricorn protease homolog
K6V22_RS21120	COG1506	peptidase
K6V22_RS21120	COG0823	Involved in the tonB-independent uptake of proteins
K6V22_RS21130	COG3119	arylsulfatase activity
K6V22_RS21135	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K6V22_RS21140	COG1028	Short-chain dehydrogenase reductase Sdr
K6V22_RS21150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6V22_RS21180	COG1121	(ABC) transporter
K6V22_RS21190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6V22_RS21190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6V22_RS21205	COG0151	Belongs to the GarS family
K6V22_RS21210	COG1506	peptidase
K6V22_RS21210	COG0823	Involved in the tonB-independent uptake of proteins
K6V22_RS21215	COG0116	Belongs to the methyltransferase superfamily
K6V22_RS21220	COG1045	serine acetyltransferase
K6V22_RS21225	COG3275	phosphorelay sensor kinase activity
K6V22_RS21230	COG3279	Response regulator of the LytR AlgR family
K6V22_RS21240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V22_RS21240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V22_RS21255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6V22_RS21260	COG1694	Mazg nucleotide pyrophosphohydrolase
K6V22_RS21270	COG0322	excinuclease ABC activity
K6V22_RS21275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V22_RS21280	COG0445	tRNA wobble uridine modification
K6V22_RS21305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6V22_RS21335	COG2715	membrane protein required for spore maturation
K6V22_RS21345	COG2255	four-way junction helicase activity
K6V22_RS21360	COG3591	Belongs to the peptidase S1B family
K6V22_RS21370	COG0513	Belongs to the DEAD box helicase family
K6V22_RS21380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6V22_RS21395	COG0612	Peptidase, M16
K6V22_RS21410	COG1312	Catalyzes the dehydration of D-mannonate
K6V22_RS21415	COG1028	Short-chain dehydrogenase reductase Sdr
K6V22_RS21445	COG1196	nuclear chromosome segregation
K6V22_RS21445	COG0741	lytic transglycosylase activity
K6V22_RS21445	COG0739	heme binding
K6V22_RS21475	COG1196	nuclear chromosome segregation
K6V22_RS21475	COG0741	lytic transglycosylase activity
K6V22_RS21475	COG0739	heme binding