locus-tag	class	description
VU15_RS00020	COG1121	(ABC) transporter
VU15_RS00030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VU15_RS00030	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VU15_RS00045	COG0151	Belongs to the GarS family
VU15_RS00050	COG1506	peptidase
VU15_RS00050	COG0823	Involved in the tonB-independent uptake of proteins
VU15_RS00055	COG0116	Belongs to the methyltransferase superfamily
VU15_RS00060	COG1045	serine acetyltransferase
VU15_RS00065	COG3275	phosphorelay sensor kinase activity
VU15_RS00070	COG3279	Response regulator of the LytR AlgR family
VU15_RS00080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VU15_RS00080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VU15_RS00095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VU15_RS00100	COG1694	Mazg nucleotide pyrophosphohydrolase
VU15_RS00110	COG0322	excinuclease ABC activity
VU15_RS00145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VU15_RS00165	COG2715	membrane protein required for spore maturation
VU15_RS00175	COG2255	four-way junction helicase activity
VU15_RS00190	COG3591	Belongs to the peptidase S1B family
VU15_RS00205	COG0513	Belongs to the DEAD box helicase family
VU15_RS00215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VU15_RS00230	COG0612	Peptidase, M16
VU15_RS00245	COG1312	Catalyzes the dehydration of D-mannonate
VU15_RS00250	COG1028	Short-chain dehydrogenase reductase Sdr
VU15_RS00260	COG0681	Belongs to the peptidase S26 family
VU15_RS00265	COG0681	Belongs to the peptidase S26 family
VU15_RS00270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VU15_RS00300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VU15_RS00315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VU15_RS00320	COG3250	beta-galactosidase activity
VU15_RS00345	COG0561	phosphatase activity
VU15_RS00385	COG0745	RESPONSE REGULATOR receiver
VU15_RS00390	COG5002	protein histidine kinase activity
VU15_RS00395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VU15_RS00410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VU15_RS00425	COG0205	6-phosphofructokinase activity
VU15_RS00430	COG0571	ribonuclease III activity
VU15_RS00435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VU15_RS00440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VU15_RS00445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VU15_RS00450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VU15_RS00465	COG1442	glycosyl transferase family 8
VU15_RS00475	COG1215	transferase activity, transferring glycosyl groups
VU15_RS00480	COG1442	glycosyl transferase family 8
VU15_RS00480	COG1216	Glycosyl transferase, family 2
VU15_RS00485	COG1132	(ABC) transporter
VU15_RS00495	COG0328	RNA-DNA hybrid ribonuclease activity
VU15_RS00495	COG3341	Caulimovirus viroplasmin
VU15_RS00510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VU15_RS00520	COG0326	Molecular chaperone. Has ATPase activity
VU15_RS00530	COG1166	arginine decarboxylase activity
VU15_RS00535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VU15_RS00610	COG1454	alcohol dehydrogenase
VU15_RS00615	COG0235	Class ii aldolase
VU15_RS00620	COG1070	Carbohydrate kinase
VU15_RS00625	COG0738	Major facilitator superfamily
VU15_RS00645	COG0779	Required for maturation of 30S ribosomal subunits
VU15_RS00650	COG0195	Participates in both transcription termination and antitermination
VU15_RS00655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VU15_RS00665	COG0719	Fe-S assembly protein
VU15_RS00675	COG0396	ATPase activity
VU15_RS00680	COG0719	Fe-S assembly protein
VU15_RS00685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VU15_RS00690	COG0393	Putative heavy-metal-binding
VU15_RS00695	COG3345	alpha-galactosidase
VU15_RS00705	COG1629	transport
VU15_RS00780	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
VU15_RS00785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VU15_RS00800	COG2202	Pas domain
VU15_RS00800	COG2205	protein histidine kinase activity
VU15_RS00820	COG0187	DNA topoisomerase II activity
VU15_RS00825	COG0268	Binds directly to 16S ribosomal RNA
VU15_RS00835	COG1381	Involved in DNA repair and RecF pathway recombination
VU15_RS00840	COG1610	YqeY-like protein
VU15_RS00845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VU15_RS00860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VU15_RS00865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VU15_RS00870	COG0772	Belongs to the SEDS family
VU15_RS00875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VU15_RS00880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VU15_RS00885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VU15_RS00905	COG2001	Belongs to the MraZ family
VU15_RS00920	COG4771	TonB-dependent receptor
VU15_RS00945	COG0756	dUTP diphosphatase activity
VU15_RS00960	COG4942	peptidase
VU15_RS00965	COG0745	RESPONSE REGULATOR receiver
VU15_RS00965	COG2205	protein histidine kinase activity
VU15_RS00965	COG3292	Two component regulator propeller
VU15_RS00970	COG3940	Belongs to the glycosyl hydrolase 43 family
VU15_RS00985	COG3250	beta-galactosidase activity
VU15_RS01000	COG3940	Belongs to the glycosyl hydrolase 43 family
VU15_RS01015	COG0383	alpha-mannosidase activity
VU15_RS01015	COG0383	alpha-mannosidase activity
VU15_RS01020	COG1629	transport
VU15_RS01020	COG4206	TonB-dependent receptor
VU15_RS01040	COG3507	Belongs to the glycosyl hydrolase 43 family
VU15_RS01065	COG3537	Alpha-1,2-mannosidase
VU15_RS01075	COG2017	converts alpha-aldose to the beta-anomer
VU15_RS01155	COG3408	Glycogen debranching enzyme
VU15_RS01160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VU15_RS01165	COG1022	Amp-dependent synthetase and ligase
VU15_RS01185	COG2954	triphosphatase activity
VU15_RS01205	COG3250	beta-galactosidase activity
VU15_RS01210	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS01235	COG1629	transport
VU15_RS01235	COG4206	TonB-dependent receptor
VU15_RS01240	COG3292	Two component regulator propeller
VU15_RS01240	COG2205	protein histidine kinase activity
VU15_RS01240	COG0745	RESPONSE REGULATOR receiver
VU15_RS01245	COG3292	Two component regulator propeller
VU15_RS01245	COG2205	protein histidine kinase activity
VU15_RS01245	COG0745	RESPONSE REGULATOR receiver
VU15_RS01270	COG4771	TonB-dependent receptor
VU15_RS01285	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
VU15_RS01310	COG4771	TonB-dependent receptor
VU15_RS01335	COG0423	glycine-tRNA ligase activity
VU15_RS01355	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VU15_RS01365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VU15_RS01405	COG3876	Protein conserved in bacteria
VU15_RS01440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VU15_RS01445	COG3876	Protein conserved in bacteria
VU15_RS01450	COG0702	epimerase
VU15_RS01455	COG4206	TonB-dependent receptor
VU15_RS01455	COG1629	transport
VU15_RS01470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VU15_RS01475	COG0475	glutathione-regulated potassium exporter activity
VU15_RS01475	COG0589	response to stress
VU15_RS01480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VU15_RS01495	COG0733	neurotransmitter:sodium symporter activity
VU15_RS01505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VU15_RS01515	COG0076	glutamate decarboxylase activity
VU15_RS01525	COG0784	Response regulator, receiver
VU15_RS01525	COG5002	protein histidine kinase activity
VU15_RS01525	COG2198	Histidine kinase
VU15_RS01530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VU15_RS01535	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
VU15_RS01605	COG1346	cytolysis
VU15_RS01630	COG0280	phosphate acetyltransferase
VU15_RS01635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VU15_RS01640	COG1785	Belongs to the alkaline phosphatase family
VU15_RS01645	COG2151	metal-sulfur cluster biosynthetic enzyme
VU15_RS01650	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VU15_RS01655	COG2003	Belongs to the UPF0758 family
VU15_RS01660	COG1216	Glycosyl transferase, family 2
VU15_RS01660	COG0463	Glycosyl transferase, family 2
VU15_RS01675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VU15_RS01680	COG2815	serine threonine protein kinase
VU15_RS01680	COG0515	serine threonine protein kinase
VU15_RS01685	COG0564	pseudouridine synthase activity
VU15_RS01725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VU15_RS01730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VU15_RS01740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VU15_RS01760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VU15_RS01770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VU15_RS01770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VU15_RS01775	COG2890	protein-(glutamine-N5) methyltransferase activity
VU15_RS01780	COG2137	regulation of response to DNA damage stimulus
VU15_RS01785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VU15_RS01820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VU15_RS01825	COG1396	sequence-specific DNA binding
VU15_RS01825	COG1917	Cupin 2, conserved barrel domain protein
VU15_RS01830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VU15_RS01835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VU15_RS01845	COG0137	argininosuccinate synthase activity
VU15_RS01855	COG1438	arginine binding
VU15_RS01870	COG2205	protein histidine kinase activity
VU15_RS01870	COG3437	response regulator, receiver
VU15_RS01870	COG3850	Histidine kinase
VU15_RS01870	COG4999	Histidine kinase
VU15_RS01875	COG0531	amino acid
VU15_RS01885	COG0039	L-malate dehydrogenase activity
VU15_RS01890	COG2996	Protein conserved in bacteria
VU15_RS01910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VU15_RS01915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VU15_RS01940	COG1629	transport
VU15_RS01965	COG1136	(ABC) transporter
VU15_RS01965	COG0577	efflux transmembrane transporter activity
VU15_RS01970	COG0577	efflux transmembrane transporter activity
VU15_RS01970	COG1136	(ABC) transporter
VU15_RS01975	COG1136	(ABC) transporter
VU15_RS01980	COG1940	carbohydrate kinase activity
VU15_RS01985	COG0335	large ribosomal subunit rRNA binding
VU15_RS01990	COG0737	Belongs to the 5'-nucleotidase family
VU15_RS01995	COG0737	Belongs to the 5'-nucleotidase family
VU15_RS02000	COG1472	Belongs to the glycosyl hydrolase 3 family
VU15_RS02005	COG1472	Belongs to the glycosyl hydrolase 3 family
VU15_RS02010	COG1629	transport
VU15_RS02010	COG4206	TonB-dependent receptor
VU15_RS02020	COG3119	arylsulfatase activity
VU15_RS02045	COG0446	pyridine nucleotide-disulphide oxidoreductase
VU15_RS02055	COG2204	response regulator
VU15_RS02060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VU15_RS02080	COG2205	protein histidine kinase activity
VU15_RS02085	COG5002	protein histidine kinase activity
VU15_RS02100	COG4771	TonB-dependent receptor
VU15_RS02145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VU15_RS02145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VU15_RS02150	COG0436	Aminotransferase
VU15_RS02155	COG3250	beta-galactosidase activity
VU15_RS02165	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VU15_RS02170	COG0826	peptidase U32
VU15_RS02180	COG4771	TonB-dependent receptor
VU15_RS02185	COG2197	response regulator
VU15_RS02190	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VU15_RS02200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VU15_RS02205	COG0252	asparaginase activity
VU15_RS02210	COG0527	aspartate kinase activity
VU15_RS02210	COG0460	homoserine dehydrogenase
VU15_RS02215	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
VU15_RS02220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VU15_RS02275	COG1629	transport
VU15_RS02275	COG4206	TonB-dependent receptor
VU15_RS02280	COG0702	epimerase
VU15_RS02285	COG3250	beta-galactosidase activity
VU15_RS02295	COG3507	Belongs to the glycosyl hydrolase 43 family
VU15_RS02310	COG4771	TonB-dependent receptor
VU15_RS02325	COG4974	Belongs to the 'phage' integrase family
VU15_RS02555	COG2003	Belongs to the UPF0758 family
VU15_RS02570	COG4974	Belongs to the 'phage' integrase family
VU15_RS02580	COG0628	permease
VU15_RS02595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VU15_RS02610	COG2095	MarC family integral membrane protein
VU15_RS02620	COG1629	transport
VU15_RS02630	COG1629	transport
VU15_RS02635	COG4974	Belongs to the 'phage' integrase family
VU15_RS02640	COG4206	TonB-dependent receptor
VU15_RS02640	COG1629	transport
VU15_RS02650	COG4771	TonB-dependent receptor
VU15_RS02655	COG0702	epimerase
VU15_RS02660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VU15_RS02675	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
VU15_RS02675	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
VU15_RS02690	COG0531	amino acid
VU15_RS02700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VU15_RS02705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VU15_RS02710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VU15_RS02745	COG1162	GTPase activity
VU15_RS02750	COG0233	cytoplasmic translational termination
VU15_RS02770	COG0443	Heat shock 70 kDa protein
VU15_RS02785	COG0528	UMP kinase activity
VU15_RS02790	COG0534	Mate efflux family protein
VU15_RS02825	COG0792	nuclease activity
VU15_RS02845	COG1183	phosphatidylcholine synthase activity
VU15_RS02850	COG0688	phosphatidylethanolamine metabolic process
VU15_RS02860	COG3118	belongs to the thioredoxin family
VU15_RS02880	COG0577	efflux transmembrane transporter activity
VU15_RS02880	COG1136	(ABC) transporter
VU15_RS02925	COG2205	protein histidine kinase activity
VU15_RS02955	COG0714	Associated with various cellular activities
VU15_RS02970	COG0802	atpase or kinase
VU15_RS02975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VU15_RS02985	COG2234	aminopeptidase activity
VU15_RS03005	COG1629	transport
VU15_RS03025	COG3250	beta-galactosidase activity
VU15_RS03030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VU15_RS03040	COG0784	Response regulator, receiver
VU15_RS03040	COG2205	protein histidine kinase activity
VU15_RS03055	COG4206	TonB-dependent receptor
VU15_RS03055	COG1629	transport
VU15_RS03070	COG1566	PFAM secretion protein HlyD family protein
VU15_RS03095	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VU15_RS03110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VU15_RS03115	COG0742	ribosomal rna small subunit methyltransferase
VU15_RS03140	COG4771	TonB-dependent receptor
VU15_RS03150	COG3537	Alpha-1,2-mannosidase
VU15_RS03165	COG3537	Alpha-1,2-mannosidase
VU15_RS03170	COG2814	Major facilitator Superfamily
VU15_RS03185	COG0739	heme binding
VU15_RS03195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VU15_RS03200	COG3942	CHAP domain
VU15_RS03200	COG1388	LysM domain
VU15_RS03210	COG1475	DNA binding
VU15_RS03215	COG1192	Involved in chromosome partitioning
VU15_RS03220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VU15_RS03225	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VU15_RS03235	COG4589	Belongs to the CDS family
VU15_RS03240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VU15_RS03245	COG0799	negative regulation of ribosome biogenesis
VU15_RS03260	COG2239	Acts as a magnesium transporter
VU15_RS03265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VU15_RS03275	COG2195	Cleaves the N-terminal amino acid of tripeptides
VU15_RS03330	COG0668	transmembrane transport
VU15_RS03335	COG2207	Transcriptional regulator
VU15_RS03335	COG0662	Cupin 2, conserved barrel domain protein
VU15_RS03380	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
VU15_RS03395	COG2244	polysaccharide biosynthetic process
VU15_RS03420	COG1216	Glycosyl transferase, family 2
VU15_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
VU15_RS03460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VU15_RS03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VU15_RS03485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VU15_RS03500	COG0667	Aldo Keto reductase
VU15_RS03505	COG1472	Belongs to the glycosyl hydrolase 3 family
VU15_RS03510	COG4771	TonB-dependent receptor
VU15_RS03515	COG0702	epimerase
VU15_RS03555	COG5012	cobalamin binding
VU15_RS03570	COG4124	Belongs to the glycosyl hydrolase 26 family
VU15_RS03575	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
VU15_RS03580	COG2211	Major facilitator Superfamily
VU15_RS03585	COG2942	2-epimerase
VU15_RS03630	COG5002	protein histidine kinase activity
VU15_RS03630	COG2205	protein histidine kinase activity
VU15_RS03630	COG0784	Response regulator, receiver
VU15_RS03640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VU15_RS03645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VU15_RS03650	COG0713	ATP synthesis coupled electron transport
VU15_RS03655	COG0839	Belongs to the complex I subunit 6 family
VU15_RS03665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VU15_RS03670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VU15_RS03670	COG0649	NAD binding
VU15_RS03675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VU15_RS03680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VU15_RS03690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VU15_RS03695	COG0569	domain protein
VU15_RS03700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VU15_RS03705	COG1073	alpha beta
VU15_RS03720	COG3119	arylsulfatase activity
VU15_RS03735	COG3119	arylsulfatase activity
VU15_RS03745	COG4771	TonB-dependent receptor
VU15_RS03750	COG3292	Two component regulator propeller
VU15_RS03750	COG2205	protein histidine kinase activity
VU15_RS03750	COG0745	RESPONSE REGULATOR receiver
VU15_RS03755	COG2271	Major facilitator Superfamily
VU15_RS03780	COG0805	protein transport
VU15_RS03785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VU15_RS03790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VU15_RS03835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VU15_RS03840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VU15_RS03840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VU15_RS03845	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VU15_RS03850	COG1078	dGTPase activity
VU15_RS03860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VU15_RS03865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VU15_RS03870	COG1704	LemA family
VU15_RS03885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VU15_RS03890	COG2226	methyltransferase
VU15_RS03895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VU15_RS03900	COG1702	phosphate starvation-inducible protein PhoH
VU15_RS03910	COG2268	Band 7 protein
VU15_RS03920	COG5434	Belongs to the glycosyl hydrolase 28 family
VU15_RS03930	COG0101	tRNA pseudouridine synthase activity
VU15_RS03950	COG3250	beta-galactosidase activity
VU15_RS03955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VU15_RS03975	COG0457	Tetratricopeptide repeat
VU15_RS03980	COG2814	Major facilitator Superfamily
VU15_RS04010	COG1629	transport
VU15_RS04010	COG4206	TonB-dependent receptor
VU15_RS04020	COG4771	TonB-dependent receptor
VU15_RS04030	COG1629	transport
VU15_RS04030	COG4206	TonB-dependent receptor
VU15_RS04045	COG1629	transport
VU15_RS04045	COG4206	TonB-dependent receptor
VU15_RS04050	COG0702	epimerase
VU15_RS04060	COG0673	inositol 2-dehydrogenase activity
VU15_RS04100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VU15_RS04105	COG0793	Belongs to the peptidase S41A family
VU15_RS04110	COG2131	deaminase
VU15_RS04120	COG0339	signal peptide processing
VU15_RS04130	COG1970	mechanosensitive ion channel activity
VU15_RS04135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VU15_RS04135	COG0519	Catalyzes the synthesis of GMP from XMP
VU15_RS04145	COG1629	transport
VU15_RS04145	COG4206	TonB-dependent receptor
VU15_RS04155	COG4206	TonB-dependent receptor
VU15_RS04155	COG1629	transport
VU15_RS04160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VU15_RS04180	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VU15_RS04200	COG1242	4 iron, 4 sulfur cluster binding
VU15_RS04210	COG0363	glucosamine-6-phosphate deaminase activity
VU15_RS04220	COG0009	L-threonylcarbamoyladenylate synthase
VU15_RS04230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VU15_RS04235	COG0561	phosphatase activity
VU15_RS04240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VU15_RS04245	COG2873	o-acetylhomoserine
VU15_RS04300	COG0297	glycogen (starch) synthase activity
VU15_RS04305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VU15_RS04310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
VU15_RS04315	COG0543	2 iron, 2 sulfur cluster binding
VU15_RS04325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VU15_RS04330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VU15_RS04335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VU15_RS04340	COG0546	phosphoglycolate phosphatase activity
VU15_RS04345	COG0791	NLP P60 protein
VU15_RS04350	COG1131	(ABC) transporter
VU15_RS04360	COG0612	Peptidase, M16
VU15_RS04365	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VU15_RS04370	COG1597	lipid kinase activity
VU15_RS04375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VU15_RS04385	COG1136	(ABC) transporter
VU15_RS04415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VU15_RS04430	COG1674	ftsk spoiiie
VU15_RS04440	COG0492	ferredoxin-NADP+ reductase activity
VU15_RS04445	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS04480	COG1595	DNA-templated transcription, initiation
VU15_RS04495	COG3956	TIGRFAM MazG family protein
VU15_RS04505	COG0525	valine-tRNA ligase activity
VU15_RS04510	COG0784	Response regulator, receiver
VU15_RS04510	COG5002	protein histidine kinase activity
VU15_RS04510	COG2205	protein histidine kinase activity
VU15_RS04530	COG4771	TonB-dependent receptor
VU15_RS04545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VU15_RS04560	COG4206	TonB-dependent receptor
VU15_RS04560	COG1629	transport
VU15_RS04565	COG0702	epimerase
VU15_RS04570	COG3119	arylsulfatase activity
VU15_RS04575	COG3119	arylsulfatase activity
VU15_RS04595	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
VU15_RS04605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VU15_RS04625	COG1253	flavin adenine dinucleotide binding
VU15_RS04635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VU15_RS04645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VU15_RS04685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VU15_RS04695	COG2226	methyltransferase
VU15_RS04735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VU15_RS04780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VU15_RS04800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VU15_RS04825	COG4771	TonB-dependent receptor
VU15_RS04830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
VU15_RS04835	COG0563	adenylate kinase activity
VU15_RS04840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VU15_RS04845	COG1496	oxidoreductase activity
VU15_RS04865	COG2706	6-phosphogluconolactonase activity
VU15_RS04900	COG1288	antiporter activity
VU15_RS04920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VU15_RS04945	COG0564	pseudouridine synthase activity
VU15_RS04960	COG1501	Belongs to the glycosyl hydrolase 31 family
VU15_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
VU15_RS05015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VU15_RS05020	COG3586	endonuclease activity
VU15_RS05035	COG3645	SOS response
VU15_RS05065	COG0582	viral genome integration into host DNA
VU15_RS05085	COG4974	Belongs to the 'phage' integrase family
VU15_RS05100	COG0784	Response regulator, receiver
VU15_RS05100	COG5002	protein histidine kinase activity
VU15_RS05110	COG2176	DNA-directed DNA polymerase activity
VU15_RS05120	COG4864	UPF0365 protein
VU15_RS05135	COG0037	tRNA processing
VU15_RS05145	COG1477	protein flavinylation
VU15_RS05150	COG1971	Probably functions as a manganese efflux pump
VU15_RS05165	COG0463	Glycosyl transferase, family 2
VU15_RS05180	COG0148	phosphopyruvate hydratase activity
VU15_RS05190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VU15_RS05195	COG1082	Xylose isomerase domain protein TIM barrel
VU15_RS05215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VU15_RS05220	COG0193	aminoacyl-tRNA hydrolase activity
VU15_RS05225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VU15_RS05235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VU15_RS05240	COG1862	Preprotein translocase
VU15_RS05265	COG0542	response to heat
VU15_RS05275	COG0583	DNA-binding transcription factor activity
VU15_RS05280	COG2855	membrane
VU15_RS05295	COG1595	DNA-templated transcription, initiation
VU15_RS05310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VU15_RS05330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VU15_RS05350	COG0443	Heat shock 70 kDa protein
VU15_RS05360	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VU15_RS05365	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
VU15_RS05370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VU15_RS05385	COG1501	Belongs to the glycosyl hydrolase 31 family
VU15_RS05410	COG4206	TonB-dependent receptor
VU15_RS05410	COG1629	transport
VU15_RS05420	COG1408	metallophosphoesterase
VU15_RS05425	COG1368	sulfuric ester hydrolase activity
VU15_RS05435	COG3634	alkyl hydroperoxide reductase activity
VU15_RS05470	COG1760	l-serine dehydratase
VU15_RS05475	COG0598	Magnesium transport protein CorA
VU15_RS05480	COG1193	negative regulation of DNA recombination
VU15_RS05555	COG1063	alcohol dehydrogenase
VU15_RS05565	COG3118	belongs to the thioredoxin family
VU15_RS05570	COG3119	arylsulfatase activity
VU15_RS05575	COG5002	protein histidine kinase activity
VU15_RS05575	COG0784	Response regulator, receiver
VU15_RS05580	COG2855	membrane
VU15_RS05585	COG2217	Heavy metal translocating P-type atpase
VU15_RS05595	COG2885	chlorophyll binding
VU15_RS05600	COG3189	MarR family transcriptional regulator
VU15_RS05605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VU15_RS05610	COG2195	Cleaves the N-terminal amino acid of tripeptides
VU15_RS05615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VU15_RS05635	COG4651	solute:proton antiporter activity
VU15_RS05635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VU15_RS05640	COG1280	lysine exporter protein (LysE YggA)
VU15_RS05655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VU15_RS05660	COG0561	phosphatase activity
VU15_RS05665	COG1169	isochorismate synthase
VU15_RS05670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VU15_RS05685	COG4948	Mandelate Racemase Muconate Lactonizing
VU15_RS05700	COG1082	Xylose isomerase domain protein TIM barrel
VU15_RS05715	COG4771	TonB-dependent receptor
VU15_RS05745	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
VU15_RS05750	COG0783	Belongs to the Dps family
VU15_RS05755	COG0583	DNA-binding transcription factor activity
VU15_RS05775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VU15_RS05815	COG1253	flavin adenine dinucleotide binding
VU15_RS05820	COG0501	Belongs to the peptidase M48B family
VU15_RS05845	COG2873	o-acetylhomoserine
VU15_RS05850	COG0482	sulfurtransferase activity
VU15_RS05855	COG2197	response regulator
VU15_RS05865	COG1757	Na H antiporter
VU15_RS05880	COG2814	Major facilitator Superfamily
VU15_RS05885	COG4953	penicillin-binding protein 1C
VU15_RS05890	COG2373	Large extracellular alpha-helical protein
VU15_RS05900	COG1918	ferrous iron import across plasma membrane
VU15_RS05900	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VU15_RS05960	COG1086	Polysaccharide biosynthesis protein
VU15_RS05965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VU15_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
VU15_RS05990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VU15_RS06015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VU15_RS06030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VU15_RS06035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VU15_RS06045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VU15_RS06050	COG0471	metal ion transport
VU15_RS06050	COG0490	domain, Protein
VU15_RS06065	COG0346	lactoylglutathione lyase activity
VU15_RS06080	COG0259	pyridoxamine-phosphate oxidase activity
VU15_RS06085	COG1741	Belongs to the pirin family
VU15_RS06100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VU15_RS06130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VU15_RS06140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VU15_RS06180	COG0686	Belongs to the AlaDH PNT family
VU15_RS06195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VU15_RS06210	COG1629	transport
VU15_RS06225	COG3345	alpha-galactosidase
VU15_RS06240	COG0488	(ABC) transporter
VU15_RS06245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VU15_RS06250	COG3059	membrane
VU15_RS06255	COG2207	Transcriptional regulator
VU15_RS06255	COG1917	Cupin 2, conserved barrel domain protein
VU15_RS06260	COG0295	cytidine deaminase activity
VU15_RS06265	COG1388	LysM domain
VU15_RS06265	COG1705	Flagellar rod assembly protein muramidase FlgJ
VU15_RS06275	COG0577	efflux transmembrane transporter activity
VU15_RS06280	COG0577	efflux transmembrane transporter activity
VU15_RS06285	COG0577	efflux transmembrane transporter activity
VU15_RS06295	COG0577	efflux transmembrane transporter activity
VU15_RS06295	COG1136	(ABC) transporter
VU15_RS06310	COG1136	(ABC) transporter
VU15_RS06325	COG1136	(ABC) transporter
VU15_RS06345	COG0784	Response regulator, receiver
VU15_RS06345	COG2205	protein histidine kinase activity
VU15_RS06355	COG2204	response regulator
VU15_RS06465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VU15_RS06475	COG0656	L-ascorbic acid biosynthetic process
VU15_RS06495	COG1215	transferase activity, transferring glycosyl groups
VU15_RS06510	COG1216	Glycosyl transferase, family 2
VU15_RS06520	COG0438	transferase activity, transferring glycosyl groups
VU15_RS06530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VU15_RS06535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VU15_RS06540	COG1530	ribonuclease E activity
VU15_RS06555	COG3119	arylsulfatase activity
VU15_RS06560	COG0629	single-stranded DNA binding
VU15_RS06620	COG4206	TonB-dependent receptor
VU15_RS06635	COG5002	protein histidine kinase activity
VU15_RS06640	COG0745	RESPONSE REGULATOR receiver
VU15_RS06665	COG0488	(ABC) transporter
VU15_RS06680	COG5492	domain, Protein
VU15_RS06690	COG0436	Aminotransferase
VU15_RS06695	COG4591	ABC-type transport system involved in lipoprotein release permease component
VU15_RS06700	COG1215	transferase activity, transferring glycosyl groups
VU15_RS06705	COG0628	permease
VU15_RS06710	COG3852	Histidine kinase
VU15_RS06725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VU15_RS06735	COG1136	(ABC) transporter
VU15_RS06735	COG0577	efflux transmembrane transporter activity
VU15_RS06740	COG0577	efflux transmembrane transporter activity
VU15_RS06745	COG1252	NADH dehydrogenase
VU15_RS06775	COG4771	TonB-dependent receptor
VU15_RS06785	COG1620	l-lactate permease
VU15_RS06790	COG2885	chlorophyll binding
VU15_RS06790	COG3047	cAMP biosynthetic process
VU15_RS06805	COG0439	Biotin carboxylase
VU15_RS06810	COG0511	ligase activity, forming carbon-carbon bonds
VU15_RS06815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VU15_RS06850	COG0508	dehydrogenase complex catalyzes the overall conversion of
VU15_RS06855	COG0022	dehydrogenase e1 component
VU15_RS06860	COG0716	FMN binding
VU15_RS06865	COG2264	protein methyltransferase activity
VU15_RS06905	COG0590	tRNA wobble adenosine to inosine editing
VU15_RS06930	COG0673	inositol 2-dehydrogenase activity
VU15_RS06935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VU15_RS06970	COG0698	ribose 5-phosphate isomerase
VU15_RS06975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VU15_RS06980	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VU15_RS06995	COG1482	cell wall glycoprotein biosynthetic process
VU15_RS07015	COG0513	Belongs to the DEAD box helicase family
VU15_RS07020	COG4221	oxidoreductase activity
VU15_RS07035	COG3250	beta-galactosidase activity
VU15_RS07045	COG3273	potassium ion transport
VU15_RS07045	COG0471	metal ion transport
VU15_RS07050	COG0529	Catalyzes the synthesis of activated sulfate
VU15_RS07055	COG0175	sulfate reduction
VU15_RS07060	COG2895	sulfate adenylyltransferase (ATP) activity
VU15_RS07100	COG4974	Belongs to the 'phage' integrase family
VU15_RS07125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VU15_RS07130	COG0242	peptide deformylase activity
VU15_RS07145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VU15_RS07150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VU15_RS07155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VU15_RS07160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VU15_RS07170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VU15_RS07175	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
VU15_RS07190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VU15_RS07235	COG1940	carbohydrate kinase activity
VU15_RS07240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VU15_RS07250	COG2271	Major facilitator Superfamily
VU15_RS07255	COG2731	YhcH YjgK YiaL family protein
VU15_RS07260	COG1629	transport
VU15_RS07280	COG4771	TonB-dependent receptor
VU15_RS07285	COG0702	epimerase
VU15_RS07290	COG1629	transport
VU15_RS07295	COG0702	epimerase
VU15_RS07310	COG4771	TonB-dependent receptor
VU15_RS07315	COG0702	epimerase
VU15_RS07320	COG0702	epimerase
VU15_RS07325	COG4206	TonB-dependent receptor
VU15_RS07325	COG1629	transport
VU15_RS07330	COG4206	TonB-dependent receptor
VU15_RS07330	COG1629	transport
VU15_RS07345	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS07365	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS07375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS07380	COG3537	Alpha-1,2-mannosidase
VU15_RS07385	COG3250	beta-galactosidase activity
VU15_RS07390	COG4206	TonB-dependent receptor
VU15_RS07390	COG1629	transport
VU15_RS07395	COG0702	epimerase
VU15_RS07400	COG3250	beta-galactosidase activity
VU15_RS07405	COG0484	heat shock protein binding
VU15_RS07410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VU15_RS07415	COG0488	(ABC) transporter
VU15_RS07420	COG1595	DNA-templated transcription, initiation
VU15_RS07445	COG0823	Involved in the tonB-independent uptake of proteins
VU15_RS07455	COG4206	TonB-dependent receptor
VU15_RS07455	COG1629	transport
VU15_RS07465	COG3537	Alpha-1,2-mannosidase
VU15_RS07470	COG3568	Endonuclease Exonuclease Phosphatase
VU15_RS07475	COG1785	Belongs to the alkaline phosphatase family
VU15_RS07495	COG1609	Transcriptional regulator
VU15_RS07495	COG2207	Transcriptional regulator
VU15_RS07500	COG2183	response to ionizing radiation
VU15_RS07560	COG2885	chlorophyll binding
VU15_RS07675	COG2183	response to ionizing radiation
VU15_RS07685	COG0737	Belongs to the 5'-nucleotidase family
VU15_RS07690	COG1956	GAF domain-containing protein
VU15_RS07700	COG4771	TonB-dependent receptor
VU15_RS07725	COG0534	Mate efflux family protein
VU15_RS07735	COG0534	Mate efflux family protein
VU15_RS07755	COG0318	PFAM AMP-dependent synthetase and ligase
VU15_RS07760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VU15_RS07765	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VU15_RS07800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VU15_RS07810	COG3475	LICD family
VU15_RS07835	COG1086	Polysaccharide biosynthesis protein
VU15_RS07845	COG1091	dTDP-4-dehydrorhamnose reductase activity
VU15_RS07865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VU15_RS07880	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VU15_RS07885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VU15_RS07890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VU15_RS07895	COG0363	glucosamine-6-phosphate deaminase activity
VU15_RS07915	COG4413	Urea transporter
VU15_RS07960	COG3279	Response regulator of the LytR AlgR family
VU15_RS07970	COG1136	(ABC) transporter
VU15_RS07970	COG0577	efflux transmembrane transporter activity
VU15_RS07975	COG1136	(ABC) transporter
VU15_RS07980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VU15_RS08005	COG3831	ATPase activity
VU15_RS08005	COG4884	unkown
VU15_RS08020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VU15_RS08030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VU15_RS08035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VU15_RS08040	COG3250	beta-galactosidase activity
VU15_RS08065	COG0501	Belongs to the peptidase M48B family
VU15_RS08070	COG1704	LemA family
VU15_RS08075	COG1595	DNA-templated transcription, initiation
VU15_RS08085	COG4206	TonB-dependent receptor
VU15_RS08085	COG1629	transport
VU15_RS08095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VU15_RS08100	COG2885	chlorophyll binding
VU15_RS08100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VU15_RS08110	COG0697	spore germination
VU15_RS08155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VU15_RS08170	COG0456	acetyltransferase
VU15_RS08170	COG1846	Transcriptional regulator
VU15_RS08175	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
VU15_RS08180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VU15_RS08185	COG2814	Major facilitator Superfamily
VU15_RS08215	COG4771	TonB-dependent receptor
VU15_RS08400	COG0542	response to heat
VU15_RS08560	COG1309	transcriptional regulator
VU15_RS08590	COG0488	(ABC) transporter
VU15_RS08610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VU15_RS08610	COG2198	Histidine kinase
VU15_RS08610	COG2205	protein histidine kinase activity
VU15_RS08610	COG0784	Response regulator, receiver
VU15_RS08635	COG0438	transferase activity, transferring glycosyl groups
VU15_RS08650	COG2244	polysaccharide biosynthetic process
VU15_RS08655	COG1216	Glycosyl transferase, family 2
VU15_RS08655	COG1442	glycosyl transferase family 8
VU15_RS08665	COG1215	transferase activity, transferring glycosyl groups
VU15_RS08695	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VU15_RS08700	COG1805	sodium ion transport
VU15_RS08705	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VU15_RS08730	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VU15_RS08735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VU15_RS08745	COG0545	Peptidyl-prolyl cis-trans isomerase
VU15_RS08750	COG1739	Uncharacterized protein family UPF0029
VU15_RS08760	COG0778	Nitroreductase
VU15_RS08765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VU15_RS08765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VU15_RS08770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VU15_RS08800	COG2217	Heavy metal translocating P-type atpase
VU15_RS08840	COG3852	Histidine kinase
VU15_RS08845	COG2204	response regulator
VU15_RS08865	COG1136	(ABC) transporter
VU15_RS08880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VU15_RS08885	COG1755	Isoprenylcysteine carboxyl methyltransferase
VU15_RS08895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VU15_RS08910	COG1678	Uncharacterized ACR, COG1678
VU15_RS08925	COG0667	Aldo Keto reductase
VU15_RS08935	COG0656	L-ascorbic acid biosynthetic process
VU15_RS08945	COG0656	L-ascorbic acid biosynthetic process
VU15_RS08950	COG0656	L-ascorbic acid biosynthetic process
VU15_RS08960	COG0534	Mate efflux family protein
VU15_RS08965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VU15_RS08980	COG1028	Short-chain dehydrogenase reductase Sdr
VU15_RS09000	COG1979	alcohol dehydrogenase
VU15_RS09020	COG1028	Short-chain dehydrogenase reductase Sdr
VU15_RS09025	COG0667	Aldo Keto reductase
VU15_RS09040	COG2311	Membrane
VU15_RS09045	COG0667	Aldo Keto reductase
VU15_RS09105	COG4771	TonB-dependent receptor
VU15_RS09130	COG1309	transcriptional regulator
VU15_RS09145	COG1132	(ABC) transporter
VU15_RS09155	COG3437	response regulator, receiver
VU15_RS09155	COG2205	protein histidine kinase activity
VU15_RS09155	COG4999	Histidine kinase
VU15_RS09155	COG3850	Histidine kinase
VU15_RS09170	COG1522	sequence-specific DNA binding
VU15_RS09190	COG3969	phosphoadenosine phosphosulfate
VU15_RS09195	COG1475	DNA binding
VU15_RS09235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VU15_RS09240	COG0745	RESPONSE REGULATOR receiver
VU15_RS09255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS09265	COG4206	TonB-dependent receptor
VU15_RS09265	COG1629	transport
VU15_RS09275	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VU15_RS09295	COG1022	Amp-dependent synthetase and ligase
VU15_RS09300	COG3263	regulation of cellular component size
VU15_RS09345	COG1136	(ABC) transporter
VU15_RS09345	COG0577	efflux transmembrane transporter activity
VU15_RS09360	COG0534	Mate efflux family protein
VU15_RS09365	COG1011	Hydrolase
VU15_RS09370	COG0167	dihydroorotate dehydrogenase activity
VU15_RS09380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VU15_RS09395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VU15_RS09410	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VU15_RS09420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VU15_RS09430	COG0356	it plays a direct role in the translocation of protons across the membrane
VU15_RS09435	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VU15_RS09440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VU15_RS09445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VU15_RS09450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VU15_RS09455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VU15_RS09460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VU15_RS09465	COG3118	belongs to the thioredoxin family
VU15_RS09485	COG0745	RESPONSE REGULATOR receiver
VU15_RS09490	COG5002	protein histidine kinase activity
VU15_RS09520	COG1120	ATPase activity
VU15_RS09525	COG1091	dTDP-4-dehydrorhamnose reductase activity
VU15_RS09555	COG2202	Pas domain
VU15_RS09555	COG2205	protein histidine kinase activity
VU15_RS09560	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VU15_RS09570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VU15_RS09585	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VU15_RS09590	COG0540	Belongs to the ATCase OTCase family
VU15_RS09600	COG2431	L-lysine efflux transmembrane transporter activity
VU15_RS09625	COG2837	iron assimilation
VU15_RS09635	COG1629	transport
VU15_RS09635	COG4206	TonB-dependent receptor
VU15_RS09655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VU15_RS09665	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VU15_RS09685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VU15_RS09720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VU15_RS09725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VU15_RS09735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VU15_RS09745	COG0673	inositol 2-dehydrogenase activity
VU15_RS09775	COG0671	phosphoesterase, PA-phosphatase related
VU15_RS09785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VU15_RS09790	COG0045	succinate-CoA ligase (ADP-forming) activity
VU15_RS09795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VU15_RS09800	COG0351	phosphomethylpyrimidine kinase
VU15_RS09810	COG1070	Carbohydrate kinase
VU15_RS09820	COG0477	Major facilitator Superfamily
VU15_RS09820	COG2814	Major facilitator Superfamily
VU15_RS09830	COG3153	acetyltransferase
VU15_RS09830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VU15_RS09835	COG0450	alkyl hydroperoxide reductase
VU15_RS09840	COG0724	RNA recognition motif
VU15_RS09845	COG1858	cytochrome C peroxidase
VU15_RS09850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VU15_RS09870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VU15_RS09880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VU15_RS09895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VU15_RS09945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VU15_RS09955	COG1904	glucuronate isomerase
VU15_RS09985	COG0513	Belongs to the DEAD box helicase family
VU15_RS09990	COG3830	Belongs to the UPF0237 family
VU15_RS09990	COG0560	Phosphoserine phosphatase
VU15_RS10005	COG0343	queuine tRNA-ribosyltransferase activity
VU15_RS10010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VU15_RS10015	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VU15_RS10110	COG0653	protein targeting
VU15_RS10115	COG3935	DnaD domain protein
VU15_RS10255	COG4974	Belongs to the 'phage' integrase family
VU15_RS10260	COG4974	Belongs to the 'phage' integrase family
VU15_RS10315	COG1192	Involved in chromosome partitioning
VU15_RS10345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VU15_RS10415	COG2205	protein histidine kinase activity
VU15_RS10420	COG2204	response regulator
VU15_RS10440	COG0577	efflux transmembrane transporter activity
VU15_RS10440	COG1136	(ABC) transporter
VU15_RS10465	COG1136	(ABC) transporter
VU15_RS10465	COG0577	efflux transmembrane transporter activity
VU15_RS10475	COG0156	8-amino-7-oxononanoate synthase activity
VU15_RS10480	COG1597	lipid kinase activity
VU15_RS10485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VU15_RS10510	COG0577	efflux transmembrane transporter activity
VU15_RS10510	COG1136	(ABC) transporter
VU15_RS10535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VU15_RS10565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VU15_RS10580	COG0543	2 iron, 2 sulfur cluster binding
VU15_RS10585	COG0167	dihydroorotate dehydrogenase activity
VU15_RS10590	COG0336	Belongs to the RNA methyltransferase TrmD family
VU15_RS10595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VU15_RS10600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VU15_RS10610	COG2315	Protein conserved in bacteria
VU15_RS10640	COG0326	Molecular chaperone. Has ATPase activity
VU15_RS10645	COG0542	response to heat
VU15_RS10690	COG2304	oxidoreductase activity
VU15_RS10705	COG0714	Associated with various cellular activities
VU15_RS10710	COG1652	LysM domain
VU15_RS10720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VU15_RS10725	COG0552	protein localization to endoplasmic reticulum
VU15_RS10730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VU15_RS10735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VU15_RS10745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VU15_RS10760	COG0442	prolyl-tRNA aminoacylation
VU15_RS10770	COG0793	Belongs to the peptidase S41A family
VU15_RS10770	COG4946	Tricorn protease homolog
VU15_RS10785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VU15_RS10790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VU15_RS10800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VU15_RS10810	COG1492	cobalamin metabolic process
VU15_RS10855	COG2096	Adenosyltransferase
VU15_RS10860	COG1797	cobyrinic acid a,c-diamide synthase activity
VU15_RS10875	COG2966	Psort location CytoplasmicMembrane, score
VU15_RS10885	COG4771	TonB-dependent receptor
VU15_RS10895	COG4774	siderophore transport
VU15_RS10905	COG1429	ligase activity, forming nitrogen-metal bonds
VU15_RS10940	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
VU15_RS11010	COG0352	thiamine-phosphate diphosphorylase activity
VU15_RS11015	COG2022	thiamine diphosphate biosynthetic process
VU15_RS11040	COG0352	thiamine-phosphate diphosphorylase activity
VU15_RS11070	COG0358	DNA primase activity
VU15_RS11205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VU15_RS11330	COG1192	Involved in chromosome partitioning
VU15_RS11365	COG0574	Belongs to the PEP-utilizing enzyme family
VU15_RS11365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VU15_RS11370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VU15_RS11375	COG0564	pseudouridine synthase activity
VU15_RS11390	COG0024	Methionine aminopeptidase
VU15_RS11415	COG0481	GTPase activity
VU15_RS11435	COG0708	Exodeoxyribonuclease III
VU15_RS11440	COG1914	H( )-stimulated, divalent metal cation uptake system
VU15_RS11455	COG0217	transcriptional regulatory protein
VU15_RS11460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VU15_RS11460	COG0072	phenylalanine-tRNA ligase activity
VU15_RS11465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VU15_RS11475	COG0297	glycogen (starch) synthase activity
VU15_RS11485	COG0438	transferase activity, transferring glycosyl groups
VU15_RS11495	COG1216	Glycosyl transferase, family 2
VU15_RS11505	COG1215	transferase activity, transferring glycosyl groups
VU15_RS11510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VU15_RS11555	COG0305	Participates in initiation and elongation during chromosome replication
VU15_RS11575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VU15_RS11580	COG4657	Part of a membrane complex involved in electron transport
VU15_RS11585	COG4660	Part of a membrane complex involved in electron transport
VU15_RS11590	COG4659	FMN binding
VU15_RS11595	COG4658	electron transport chain
VU15_RS11600	COG4656	Part of a membrane complex involved in electron transport
VU15_RS11625	COG0504	CTP synthase activity
VU15_RS11635	COG0534	Mate efflux family protein
VU15_RS11640	COG0823	Involved in the tonB-independent uptake of proteins
VU15_RS11640	COG1506	peptidase
VU15_RS11655	COG1695	Transcriptional regulator
VU15_RS11670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VU15_RS11680	COG1388	LysM domain
VU15_RS11680	COG3942	CHAP domain
VU15_RS11710	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
VU15_RS11715	COG0556	nucleotide-excision repair
VU15_RS11720	COG2949	membrane
VU15_RS11745	COG1752	Esterase of the alpha-beta hydrolase superfamily
VU15_RS11780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VU15_RS11800	COG0842	Transport permease protein
VU15_RS11805	COG1131	(ABC) transporter
VU15_RS11835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VU15_RS11840	COG0505	Belongs to the CarA family
VU15_RS11850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VU15_RS11855	COG0367	asparagine synthase
VU15_RS11880	COG0436	Aminotransferase
VU15_RS11890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VU15_RS11900	COG1979	alcohol dehydrogenase
VU15_RS11910	COG0133	tryptophan synthase activity
VU15_RS11915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VU15_RS11920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VU15_RS11920	COG0512	Glutamine amidotransferase of anthranilate synthase
VU15_RS11925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VU15_RS11930	COG0134	indole-3-glycerol-phosphate synthase activity
VU15_RS11935	COG0135	phosphoribosylanthranilate isomerase activity
VU15_RS11940	COG0159	tryptophan synthase activity
VU15_RS11945	COG0252	asparaginase activity
VU15_RS11960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VU15_RS11970	COG0110	maltose O-acetyltransferase activity
VU15_RS11975	COG2197	response regulator
VU15_RS11985	COG0138	bifunctional purine biosynthesis protein purh
VU15_RS11990	COG0716	FMN binding
VU15_RS12015	COG1858	cytochrome C peroxidase
VU15_RS12025	COG4771	TonB-dependent receptor
VU15_RS12035	COG2814	Major facilitator Superfamily
VU15_RS12040	COG1566	PFAM secretion protein HlyD family protein
VU15_RS12070	COG4771	TonB-dependent receptor
VU15_RS12095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VU15_RS12100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VU15_RS12110	COG2966	Psort location CytoplasmicMembrane, score
VU15_RS12115	COG3610	response to peptide
VU15_RS12130	COG1609	Transcriptional regulator
VU15_RS12140	COG1733	regulation of RNA biosynthetic process
VU15_RS12145	COG2205	protein histidine kinase activity
VU15_RS12145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VU15_RS12145	COG0784	Response regulator, receiver
VU15_RS12145	COG2198	Histidine kinase
VU15_RS12165	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VU15_RS12170	COG1690	Belongs to the RtcB family
VU15_RS12190	COG0228	four-way junction DNA binding
VU15_RS12205	COG0724	RNA recognition motif
VU15_RS12215	COG1177	transmembrane transport
VU15_RS12220	COG1176	ABC-type spermidine putrescine transport system, permease component I
VU15_RS12230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VU15_RS12240	COG0058	SHG alpha-glucan phosphorylase activity
VU15_RS12250	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VU15_RS12270	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
VU15_RS12320	COG0745	RESPONSE REGULATOR receiver
VU15_RS12325	COG5002	protein histidine kinase activity
VU15_RS12350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VU15_RS12355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VU15_RS12365	COG4948	Mandelate Racemase Muconate Lactonizing
VU15_RS12375	COG1295	ribonuclease BN
VU15_RS12380	COG0778	Nitroreductase
VU15_RS12390	COG0704	Plays a role in the regulation of phosphate uptake
VU15_RS12395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VU15_RS12400	COG0581	inorganic phosphate transmembrane transporter activity
VU15_RS12405	COG0573	inorganic phosphate transmembrane transporter activity
VU15_RS12415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VU15_RS12435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VU15_RS12470	COG3023	N-Acetylmuramoyl-L-alanine amidase
VU15_RS12520	COG1216	Glycosyl transferase, family 2
VU15_RS12525	COG1216	Glycosyl transferase, family 2
VU15_RS12565	COG0438	transferase activity, transferring glycosyl groups
VU15_RS12585	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VU15_RS12635	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VU15_RS12665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VU15_RS12670	COG0167	dihydroorotate dehydrogenase activity
VU15_RS12735	COG5002	protein histidine kinase activity
VU15_RS12750	COG2172	sigma factor antagonist activity
VU15_RS12760	COG2208	phosphoserine phosphatase activity
VU15_RS12785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VU15_RS12805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VU15_RS12810	COG0497	DNA recombination
VU15_RS12820	COG2176	DNA-directed DNA polymerase activity
VU15_RS12820	COG5002	protein histidine kinase activity
VU15_RS12825	COG0592	DNA-directed DNA polymerase activity
VU15_RS12840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VU15_RS12840	COG0321	lipoyl(octanoyl) transferase activity
VU15_RS12855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VU15_RS12860	COG0156	8-amino-7-oxononanoate synthase activity
VU15_RS12945	COG0019	diaminopimelate decarboxylase activity
VU15_RS12950	COG0527	aspartate kinase activity
VU15_RS12955	COG2884	Cell division ATP-binding protein ftsE
VU15_RS12960	COG0140	phosphoribosyl-ATP diphosphatase activity
VU15_RS12960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VU15_RS12970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VU15_RS12975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VU15_RS12990	COG3586	endonuclease activity
VU15_RS13025	COG1472	Belongs to the glycosyl hydrolase 3 family
VU15_RS13030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VU15_RS13040	COG5012	cobalamin binding
VU15_RS13050	COG1472	Belongs to the glycosyl hydrolase 3 family
VU15_RS13055	COG0702	epimerase
VU15_RS13060	COG4771	TonB-dependent receptor
VU15_RS13075	COG0693	protein deglycase activity
VU15_RS13085	COG0494	nUDIX hydrolase
VU15_RS13090	COG1401	restriction endodeoxyribonuclease activity
VU15_RS13150	COG4977	sequence-specific DNA binding
VU15_RS13150	COG1917	Cupin 2, conserved barrel domain protein
VU15_RS13155	COG2814	Major facilitator Superfamily
VU15_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
VU15_RS13165	COG2207	Transcriptional regulator
VU15_RS13180	COG1090	epimerase
VU15_RS13210	COG0561	phosphatase activity
VU15_RS13215	COG4206	TonB-dependent receptor
VU15_RS13215	COG1629	transport
VU15_RS13265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VU15_RS13275	COG0363	glucosamine-6-phosphate deaminase activity
VU15_RS13315	COG1032	radical SAM domain protein
VU15_RS13320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VU15_RS13325	COG0463	Glycosyl transferase, family 2
VU15_RS13330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VU15_RS13340	COG0646	methionine synthase
VU15_RS13340	COG1410	methionine synthase
VU15_RS13395	COG1408	metallophosphoesterase
VU15_RS13400	COG1132	(ABC) transporter
VU15_RS13405	COG1132	(ABC) transporter
VU15_RS13420	COG0420	3'-5' exonuclease activity
VU15_RS13445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VU15_RS13455	COG0681	Belongs to the peptidase S26 family
VU15_RS13535	COG0641	radical SAM
VU15_RS13540	COG3591	Belongs to the peptidase S1B family
VU15_RS13545	COG3591	Belongs to the peptidase S1B family
VU15_RS13580	COG1773	rubredoxin
VU15_RS13580	COG1592	Rubrerythrin
VU15_RS13590	COG3152	Membrane
VU15_RS13595	COG0339	signal peptide processing
VU15_RS13600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VU15_RS13600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VU15_RS13610	COG1629	transport
VU15_RS13610	COG4206	TonB-dependent receptor
VU15_RS13625	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VU15_RS13625	COG0131	Imidazoleglycerol-phosphate dehydratase
VU15_RS13635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VU15_RS13640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VU15_RS13650	COG1741	Belongs to the pirin family
VU15_RS13655	COG4232	protein-disulfide reductase activity
VU15_RS13665	COG0572	uridine kinase
VU15_RS13675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VU15_RS13685	COG1410	methionine synthase
VU15_RS13685	COG0646	methionine synthase
VU15_RS13690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VU15_RS13725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VU15_RS13735	COG1295	ribonuclease BN
VU15_RS13760	COG2205	protein histidine kinase activity
VU15_RS13760	COG2202	Pas domain
VU15_RS13765	COG0534	Mate efflux family protein
VU15_RS13770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VU15_RS13775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VU15_RS13780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VU15_RS13785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VU15_RS13845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VU15_RS13885	COG2195	Cleaves the N-terminal amino acid of tripeptides
VU15_RS13895	COG0668	transmembrane transport
VU15_RS13910	COG3250	beta-galactosidase activity
VU15_RS13915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS13920	COG3119	arylsulfatase activity
VU15_RS13925	COG3119	arylsulfatase activity
VU15_RS13930	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS13935	COG3292	Two component regulator propeller
VU15_RS13935	COG0745	RESPONSE REGULATOR receiver
VU15_RS13935	COG2205	protein histidine kinase activity
VU15_RS13940	COG1830	Aldolase
VU15_RS13945	COG0588	phosphoglycerate mutase activity
VU15_RS13955	COG1119	ATPase activity
VU15_RS13965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS13975	COG1629	transport
VU15_RS13975	COG4206	TonB-dependent receptor
VU15_RS13985	COG1595	DNA-templated transcription, initiation
VU15_RS13990	COG1523	belongs to the glycosyl hydrolase 13 family
VU15_RS13995	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VU15_RS14095	COG3179	chitinase
VU15_RS14250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VU15_RS14260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VU15_RS14265	COG0126	phosphoglycerate kinase activity
VU15_RS14280	COG2311	Membrane
VU15_RS14380	COG4771	TonB-dependent receptor
VU15_RS14385	COG0702	epimerase
VU15_RS14420	COG1192	Involved in chromosome partitioning
VU15_RS14450	COG1196	nuclear chromosome segregation
VU15_RS14450	COG0739	heme binding
VU15_RS14450	COG0741	lytic transglycosylase activity
VU15_RS14645	COG0424	maF-like protein
VU15_RS14650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VU15_RS14665	COG0778	Nitroreductase
VU15_RS14670	COG0288	reversible hydration of carbon dioxide
VU15_RS14685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VU15_RS14695	COG5016	pyruvate
VU15_RS14695	COG0511	ligase activity, forming carbon-carbon bonds
VU15_RS14700	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VU15_RS14715	COG0366	Alpha amylase catalytic
VU15_RS14735	COG0191	fructose-bisphosphate aldolase activity
VU15_RS14745	COG0254	rRNA binding
VU15_RS14770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VU15_RS14775	COG1629	transport
VU15_RS14775	COG4206	TonB-dependent receptor
VU15_RS14780	COG1609	Transcriptional regulator
VU15_RS14790	COG1554	hydrolase, family 65, central catalytic
VU15_RS14795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VU15_RS14815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VU15_RS14815	COG0047	phosphoribosylformylglycinamidine synthase activity
VU15_RS14820	COG2205	protein histidine kinase activity
VU15_RS14820	COG0745	RESPONSE REGULATOR receiver
VU15_RS14820	COG3292	Two component regulator propeller
VU15_RS14835	COG1649	PFAM Uncharacterised BCR, COG1649
VU15_RS14855	COG1966	Carbon starvation protein
VU15_RS14860	COG1649	PFAM Uncharacterised BCR, COG1649
VU15_RS14865	COG0784	Response regulator, receiver
VU15_RS14865	COG2205	protein histidine kinase activity
VU15_RS14895	COG2113	Glycine betaine
VU15_RS14900	COG4176	ABC-type proline glycine betaine transport system permease component
VU15_RS14930	COG1621	beta-fructofuranosidase activity
VU15_RS14960	COG0738	Major facilitator superfamily
VU15_RS14975	COG1752	Esterase of the alpha-beta hydrolase superfamily
VU15_RS14980	COG0475	glutathione-regulated potassium exporter activity
VU15_RS15005	COG3015	lipoprotein NlpE involved in copper resistance
VU15_RS15025	COG4977	sequence-specific DNA binding
VU15_RS15025	COG1917	Cupin 2, conserved barrel domain protein
VU15_RS15050	COG4771	TonB-dependent receptor
VU15_RS15055	COG0702	epimerase
VU15_RS15070	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VU15_RS15090	COG0484	heat shock protein binding
VU15_RS15100	COG2194	sulfuric ester hydrolase activity
VU15_RS15145	COG0028	Belongs to the TPP enzyme family
VU15_RS15170	COG0459	protein refolding
VU15_RS15175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VU15_RS15215	COG2326	polyphosphate kinase activity
VU15_RS15245	COG3537	Alpha-1,2-mannosidase
VU15_RS15250	COG0823	Involved in the tonB-independent uptake of proteins
VU15_RS15250	COG1506	peptidase
VU15_RS15280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VU15_RS15320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VU15_RS15330	COG0671	phosphoesterase, PA-phosphatase related
VU15_RS15350	COG0702	epimerase
VU15_RS15355	COG4206	TonB-dependent receptor
VU15_RS15355	COG1629	transport
VU15_RS15375	COG0463	Glycosyl transferase, family 2
VU15_RS15390	COG0066	3-isopropylmalate dehydratase activity
VU15_RS15395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VU15_RS15400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VU15_RS15450	COG0616	signal peptide processing
VU15_RS15460	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VU15_RS15465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VU15_RS15475	COG4974	Belongs to the 'phage' integrase family
VU15_RS15545	COG2378	regulation of single-species biofilm formation
VU15_RS15550	COG3340	Belongs to the peptidase S51 family
VU15_RS15615	COG1431	PFAM Stem cell self-renewal protein Piwi
VU15_RS15620	COG0546	phosphoglycolate phosphatase activity
VU15_RS15635	COG2207	Transcriptional regulator
VU15_RS15640	COG2205	protein histidine kinase activity
VU15_RS15640	COG3292	Two component regulator propeller
VU15_RS15640	COG0745	RESPONSE REGULATOR receiver
VU15_RS15645	COG4948	Mandelate Racemase Muconate Lactonizing
VU15_RS15665	COG0702	epimerase
VU15_RS15670	COG1629	transport
VU15_RS15670	COG4206	TonB-dependent receptor
VU15_RS15700	COG2207	Transcriptional regulator
VU15_RS15700	COG1917	Cupin 2, conserved barrel domain protein
VU15_RS15715	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
VU15_RS15730	COG1028	Short-chain dehydrogenase reductase Sdr
VU15_RS15800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VU15_RS15810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VU15_RS15810	COG4651	solute:proton antiporter activity
VU15_RS15815	COG0439	Biotin carboxylase
VU15_RS15820	COG0511	ligase activity, forming carbon-carbon bonds
VU15_RS15820	COG5016	pyruvate
VU15_RS15825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VU15_RS15830	COG1335	isochorismatase
VU15_RS15840	COG0516	GMP reductase activity
VU15_RS15840	COG0517	IMP dehydrogenase activity
VU15_RS15855	COG2207	Transcriptional regulator
VU15_RS15860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VU15_RS15875	COG2873	o-acetylhomoserine
VU15_RS15925	COG2076	Multidrug Resistance protein
VU15_RS15950	COG2217	Heavy metal translocating P-type atpase
VU15_RS15960	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VU15_RS15970	COG1388	LysM domain
VU15_RS15970	COG0741	lytic transglycosylase activity
VU15_RS15975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VU15_RS15990	COG1285	pathogenesis
VU15_RS16010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VU15_RS16010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VU15_RS16025	COG1115	amino acid carrier protein
VU15_RS16035	COG1509	lysine 2,3-aminomutase activity
VU15_RS16040	COG2233	PERMEase
VU15_RS16055	COG1393	Belongs to the ArsC family
VU15_RS16065	COG4206	TonB-dependent receptor
VU15_RS16065	COG1629	transport
VU15_RS16080	COG4589	Belongs to the CDS family
VU15_RS16090	COG2304	oxidoreductase activity
VU15_RS16100	COG0351	phosphomethylpyrimidine kinase
VU15_RS16110	COG1139	Iron-sulfur cluster binding protein
VU15_RS16115	COG0247	lactate metabolic process
VU15_RS16120	COG0602	queuosine metabolic process
VU15_RS16130	COG2832	Protein of unknown function (DUF454)
VU15_RS16135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VU15_RS16150	COG3142	Participates in the control of copper homeostasis
VU15_RS16155	COG1418	mRNA catabolic process
VU15_RS16175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VU15_RS16190	COG4771	TonB-dependent receptor
VU15_RS16305	COG0617	tRNA 3'-terminal CCA addition
VU15_RS16305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VU15_RS16305	COG0517	IMP dehydrogenase activity
VU15_RS16330	COG0612	Peptidase, M16
VU15_RS16340	COG1278	Cold shock
VU15_RS16395	COG0110	maltose O-acetyltransferase activity
VU15_RS16415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VU15_RS16430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VU15_RS16440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VU15_RS16480	COG0776	regulation of translation
VU15_RS16485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VU15_RS16515	COG0632	four-way junction helicase activity
VU15_RS16520	COG0673	inositol 2-dehydrogenase activity
VU15_RS16525	COG1272	protein, Hemolysin III
VU15_RS16530	COG1328	CTP reductase activity
VU15_RS16535	COG0602	queuosine metabolic process
VU15_RS16540	COG2814	Major facilitator Superfamily
VU15_RS16550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VU15_RS16560	COG0750	zinc metalloprotease
VU15_RS16575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VU15_RS16580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VU15_RS16590	COG1214	PFAM Peptidase M22, glycoprotease
VU15_RS16605	COG0194	GDP metabolic process
VU15_RS16610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VU15_RS16615	COG1408	metallophosphoesterase
VU15_RS16620	COG1575	Belongs to the MenA family. Type 1 subfamily
VU15_RS16625	COG1088	dTDP-glucose 4,6-dehydratase activity
VU15_RS16630	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
VU15_RS16650	COG2204	response regulator
VU15_RS16655	COG0488	(ABC) transporter
VU15_RS16720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VU15_RS16730	COG1522	sequence-specific DNA binding
VU15_RS16755	COG0811	peptide transport
VU15_RS16765	COG0084	hydrolase, TatD family'
VU15_RS16780	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VU15_RS16785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VU15_RS16790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VU15_RS16795	COG0205	6-phosphofructokinase activity
VU15_RS16815	COG0372	Belongs to the citrate synthase family
VU15_RS16820	COG0538	isocitrate dehydrogenase activity
VU15_RS16830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VU15_RS16840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VU15_RS16865	COG0129	dihydroxy-acid dehydratase activity
VU15_RS16890	COG2885	chlorophyll binding
VU15_RS16910	COG3681	Belongs to the UPF0597 family
VU15_RS16945	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VU15_RS16955	COG0702	epimerase
VU15_RS16960	COG4771	TonB-dependent receptor
VU15_RS16975	COG0702	epimerase
VU15_RS16980	COG4206	TonB-dependent receptor
VU15_RS16980	COG1629	transport
VU15_RS16985	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS16985	COG3291	Pkd domain containing protein
VU15_RS16995	COG4771	TonB-dependent receptor
VU15_RS17010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VU15_RS17050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VU15_RS17050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VU15_RS17055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VU15_RS17085	COG1752	Esterase of the alpha-beta hydrolase superfamily
VU15_RS17090	COG0534	Mate efflux family protein
VU15_RS17095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VU15_RS17100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VU15_RS17105	COG0166	Belongs to the GPI family
VU15_RS17115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VU15_RS17125	COG2502	aspartate--ammonia ligase
VU15_RS17130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VU15_RS17145	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS17155	COG1472	Belongs to the glycosyl hydrolase 3 family
VU15_RS17170	COG0860	N-Acetylmuramoyl-L-alanine amidase
VU15_RS17180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VU15_RS17195	COG1640	4-alpha-glucanotransferase
VU15_RS17205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VU15_RS17210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VU15_RS17235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VU15_RS17240	COG1022	Amp-dependent synthetase and ligase
VU15_RS17255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VU15_RS17260	COG0360	Binds together with S18 to 16S ribosomal RNA
VU15_RS17280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VU15_RS17290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VU15_RS17310	COG4771	TonB-dependent receptor
VU15_RS17325	COG2431	L-lysine efflux transmembrane transporter activity
VU15_RS17365	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VU15_RS17370	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
VU15_RS17375	COG0386	Belongs to the glutathione peroxidase family
VU15_RS17395	COG3275	phosphorelay sensor kinase activity
VU15_RS17400	COG3279	Response regulator of the LytR AlgR family
VU15_RS17420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VU15_RS17435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VU15_RS17445	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VU15_RS17450	COG0658	competence protein
VU15_RS17455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VU15_RS17460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VU15_RS17470	COG0009	L-threonylcarbamoyladenylate synthase
VU15_RS17515	COG0438	transferase activity, transferring glycosyl groups
VU15_RS17525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VU15_RS17540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VU15_RS17555	COG0438	transferase activity, transferring glycosyl groups
VU15_RS17560	COG1045	serine acetyltransferase
VU15_RS17570	COG0438	transferase activity, transferring glycosyl groups
VU15_RS17625	COG2818	Glycosylase
VU15_RS17630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VU15_RS17630	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
VU15_RS17635	COG0514	ATP-dependent DNA helicase (RecQ)
VU15_RS17645	COG2271	Major facilitator Superfamily
VU15_RS17660	COG0702	epimerase
VU15_RS17665	COG4771	TonB-dependent receptor
VU15_RS17670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VU15_RS17675	COG2186	Transcriptional regulator
VU15_RS17685	COG0436	Aminotransferase
VU15_RS17690	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
VU15_RS17705	COG0358	DNA primase activity
VU15_RS17710	COG3119	arylsulfatase activity
VU15_RS17740	COG0302	gtp cyclohydrolase
VU15_RS17750	COG0149	triose-phosphate isomerase activity
VU15_RS17765	COG0739	heme binding
VU15_RS17770	COG0105	UTP biosynthetic process
VU15_RS17775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VU15_RS17780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VU15_RS17800	COG0811	peptide transport
VU15_RS17810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VU15_RS17860	COG1629	transport
VU15_RS17895	COG0039	L-malate dehydrogenase activity
VU15_RS17925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VU15_RS17940	COG4948	Mandelate Racemase Muconate Lactonizing
VU15_RS17960	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VU15_RS17965	COG3118	belongs to the thioredoxin family
VU15_RS17970	COG0489	protein tyrosine kinase activity
VU15_RS17985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VU15_RS17990	COG1722	exodeoxyribonuclease VII activity
VU15_RS17995	COG1570	exodeoxyribonuclease VII activity
VU15_RS18005	COG0482	sulfurtransferase activity
VU15_RS18025	COG0179	Fumarylacetoacetate (FAA) hydrolase
VU15_RS18030	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
VU15_RS18040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VU15_RS18045	COG0052	Belongs to the universal ribosomal protein uS2 family
VU15_RS18050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VU15_RS18055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VU15_RS18065	COG0017	Asparaginyl-tRNA synthetase
VU15_RS18070	COG1187	pseudouridine synthase activity
VU15_RS18100	COG0110	maltose O-acetyltransferase activity
VU15_RS18110	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS18165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VU15_RS18200	COG1216	Glycosyl transferase, family 2
VU15_RS18200	COG1442	glycosyl transferase family 8
VU15_RS18225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VU15_RS18255	COG0297	glycogen (starch) synthase activity
VU15_RS18335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VU15_RS18350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VU15_RS18365	COG0517	IMP dehydrogenase activity
VU15_RS18365	COG0516	GMP reductase activity
VU15_RS18370	COG0514	ATP-dependent DNA helicase (RecQ)
VU15_RS18375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VU15_RS18400	COG0724	RNA recognition motif
VU15_RS18410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VU15_RS18415	COG1127	ABC transporter
VU15_RS18575	COG0741	lytic transglycosylase activity
VU15_RS18575	COG1196	nuclear chromosome segregation
VU15_RS18575	COG0739	heme binding
VU15_RS18605	COG1192	Involved in chromosome partitioning
VU15_RS18640	COG0702	epimerase
VU15_RS18645	COG4771	TonB-dependent receptor
VU15_RS18740	COG2197	response regulator
VU15_RS18745	COG1160	GTP binding
VU15_RS18750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VU15_RS18755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VU15_RS18805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VU15_RS18810	COG0470	DNA polymerase III
VU15_RS18815	COG1774	PSP1 C-terminal conserved region
VU15_RS18825	COG0772	Belongs to the SEDS family
VU15_RS18840	COG1792	Involved in formation and maintenance of cell shape
VU15_RS18850	COG0138	bifunctional purine biosynthesis protein purh
VU15_RS18855	COG3590	peptidase
VU15_RS18860	COG0488	(ABC) transporter
VU15_RS18885	COG2205	protein histidine kinase activity
VU15_RS18885	COG0784	Response regulator, receiver
VU15_RS18890	COG0534	Mate efflux family protein
VU15_RS18895	COG0612	Peptidase, M16
VU15_RS18915	COG0564	pseudouridine synthase activity
VU15_RS18950	COG2312	Erythromycin esterase
VU15_RS18970	COG1131	(ABC) transporter
VU15_RS19060	COG1696	Membrane protein involved in D-alanine export
VU15_RS19100	COG2986	histidine ammonia-lyase
VU15_RS19110	COG1228	amidohydrolase
VU15_RS19120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VU15_RS19150	COG0203	ribosomal protein L17
VU15_RS19155	COG0202	RNA polymerase activity
VU15_RS19160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VU15_RS19165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VU15_RS19170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VU15_RS19175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VU15_RS19190	COG0200	Binds to the 23S rRNA
VU15_RS19195	COG1841	ribosomal large subunit assembly
VU15_RS19200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VU15_RS19205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VU15_RS19210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VU15_RS19215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VU15_RS19220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VU15_RS19225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VU15_RS19230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VU15_RS19235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VU15_RS19240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VU15_RS19245	COG0255	Belongs to the universal ribosomal protein uL29 family
VU15_RS19250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VU15_RS19255	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VU15_RS19260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VU15_RS19265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VU15_RS19270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VU15_RS19275	COG0089	rRNA binding
VU15_RS19280	COG0088	Forms part of the polypeptide exit tunnel
VU15_RS19285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VU15_RS19290	COG0051	transcription antitermination factor activity, RNA binding
VU15_RS19295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VU15_RS19300	COG0049	tRNA binding
VU15_RS19305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VU15_RS19335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VU15_RS19340	COG0085	RNA polymerase activity
VU15_RS19345	COG0222	ribosome binding
VU15_RS19350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VU15_RS19355	COG0081	regulation of translation
VU15_RS19360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VU15_RS19405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VU15_RS19410	COG4974	Belongs to the 'phage' integrase family
VU15_RS19415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VU15_RS19425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VU15_RS19435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VU15_RS19440	COG1480	7TM receptor with intracellular HD hydrolase
VU15_RS19445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VU15_RS19455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VU15_RS19470	COG1027	Aspartate ammonia-lyase
VU15_RS19475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VU15_RS19480	COG0252	asparaginase activity
VU15_RS19515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VU15_RS19525	COG4804	nuclease activity
VU15_RS19540	COG0582	viral genome integration into host DNA
VU15_RS19565	COG3292	Two component regulator propeller
VU15_RS19565	COG2205	protein histidine kinase activity
VU15_RS19565	COG0745	RESPONSE REGULATOR receiver
VU15_RS19595	COG2271	Major facilitator Superfamily
VU15_RS19605	COG4771	TonB-dependent receptor
VU15_RS19610	COG0702	epimerase
VU15_RS19620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VU15_RS19640	COG4771	TonB-dependent receptor
VU15_RS19735	COG2096	Adenosyltransferase
VU15_RS19795	COG1629	transport
VU15_RS19820	COG0657	acetylesterase activity
VU15_RS19820	COG2755	lipolytic protein G-D-S-L family
VU15_RS19835	COG3275	phosphorelay sensor kinase activity
VU15_RS19840	COG3279	Response regulator of the LytR AlgR family
VU15_RS19875	COG2197	response regulator
VU15_RS19890	COG0662	Cupin 2, conserved barrel domain protein
VU15_RS19890	COG2207	Transcriptional regulator
VU15_RS19895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VU15_RS19930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VU15_RS19950	COG4974	Belongs to the 'phage' integrase family
VU15_RS19955	COG4804	nuclease activity
VU15_RS19965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VU15_RS19985	COG1064	alcohol dehydrogenase
VU15_RS20020	COG0358	DNA primase activity
VU15_RS20055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VU15_RS20065	COG1185	polyribonucleotide nucleotidyltransferase activity
VU15_RS20080	COG4771	TonB-dependent receptor
VU15_RS20105	COG3426	butyrate kinase activity
VU15_RS20110	COG0280	phosphate acetyltransferase
VU15_RS20120	COG1619	proteins homologs of microcin C7 resistance protein MccF
VU15_RS20125	COG2234	aminopeptidase activity
VU15_RS20130	COG2166	iron-sulfur cluster assembly
VU15_RS20135	COG3655	Transcriptional regulator
VU15_RS20145	COG1266	CAAX protease self-immunity
VU15_RS20150	COG0196	riboflavin kinase activity
VU15_RS20155	COG1011	Hydrolase
VU15_RS20160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VU15_RS20170	COG1773	rubredoxin
VU15_RS20175	COG1283	sodium-dependent phosphate transmembrane transporter activity
VU15_RS20185	COG2205	protein histidine kinase activity
VU15_RS20210	COG0006	proline dipeptidase activity
VU15_RS20225	COG0509	glycine decarboxylation via glycine cleavage system
VU15_RS20230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VU15_RS20255	COG0702	epimerase
VU15_RS20260	COG4771	TonB-dependent receptor
VU15_RS20275	COG0793	Belongs to the peptidase S41A family
VU15_RS20280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VU15_RS20325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VU15_RS20330	COG1882	Formate acetyltransferase
VU15_RS20335	COG2814	Major facilitator Superfamily
VU15_RS20335	COG0477	Major facilitator Superfamily
VU15_RS20355	COG1040	competence protein
VU15_RS20360	COG0483	inositol monophosphate 1-phosphatase activity
VU15_RS20370	COG3345	alpha-galactosidase
VU15_RS20395	COG3475	LICD family
VU15_RS20400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VU15_RS20430	COG1442	glycosyl transferase family 8
VU15_RS20505	COG0018	arginyl-trna synthetase
VU15_RS20535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VU15_RS20540	COG0776	regulation of translation
VU15_RS20575	COG2207	Transcriptional regulator
VU15_RS20575	COG1609	Transcriptional regulator
VU15_RS20625	COG1396	sequence-specific DNA binding
VU15_RS20645	COG0674	pyruvate-flavodoxin oxidoreductase activity
VU15_RS20645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VU15_RS20650	COG1013	pyruvate-flavodoxin oxidoreductase activity
VU15_RS20660	COG0584	glycerophosphoryl diester phosphodiesterase
VU15_RS20665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VU15_RS20670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VU15_RS20675	COG1629	transport
VU15_RS20685	COG1629	transport
VU15_RS20725	COG1629	transport
VU15_RS20735	COG1217	gtp-binding protein TYPA
VU15_RS20740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VU15_RS20750	COG0318	PFAM AMP-dependent synthetase and ligase
VU15_RS20755	COG2205	protein histidine kinase activity
VU15_RS20755	COG5002	protein histidine kinase activity
VU15_RS20755	COG0784	Response regulator, receiver
VU15_RS20775	COG3119	arylsulfatase activity
VU15_RS20800	COG4591	ABC-type transport system involved in lipoprotein release permease component
VU15_RS20805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VU15_RS20820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VU15_RS20825	COG4974	Belongs to the 'phage' integrase family
VU15_RS20835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VU15_RS20840	COG0606	chelatase, subunit chli
VU15_RS20860	COG3292	Two component regulator propeller
VU15_RS20860	COG2205	protein histidine kinase activity
VU15_RS20860	COG0745	RESPONSE REGULATOR receiver
VU15_RS20910	COG0438	transferase activity, transferring glycosyl groups
VU15_RS20935	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VU15_RS20940	COG0438	transferase activity, transferring glycosyl groups
VU15_RS20950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VU15_RS20955	COG0545	Peptidyl-prolyl cis-trans isomerase
VU15_RS20960	COG0545	Peptidyl-prolyl cis-trans isomerase
VU15_RS20965	COG1522	sequence-specific DNA binding
VU15_RS20985	COG3275	phosphorelay sensor kinase activity
VU15_RS21060	COG4206	TonB-dependent receptor
VU15_RS21060	COG1629	transport
VU15_RS21070	COG2814	Major facilitator Superfamily
VU15_RS21090	COG0745	RESPONSE REGULATOR receiver
VU15_RS21090	COG2205	protein histidine kinase activity
VU15_RS21090	COG3292	Two component regulator propeller
VU15_RS21095	COG1621	beta-fructofuranosidase activity
VU15_RS21130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VU15_RS21135	COG0793	Belongs to the peptidase S41A family
VU15_RS21135	COG3409	Peptidoglycan-binding domain 1 protein
VU15_RS21155	COG1053	succinate dehydrogenase
VU15_RS21160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VU15_RS21175	COG4771	TonB-dependent receptor
VU15_RS21200	COG0758	DNA mediated transformation
VU15_RS21200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VU15_RS21210	COG0826	peptidase U32
VU15_RS21220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VU15_RS21235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VU15_RS21240	COG0557	exoribonuclease II activity
VU15_RS21280	COG0012	GTP binding
VU15_RS21285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VU15_RS21290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VU15_RS21300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VU15_RS21310	COG0495	leucyl-tRNA aminoacylation
VU15_RS21315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VU15_RS21325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VU15_RS21345	COG1215	transferase activity, transferring glycosyl groups
VU15_RS21395	COG0731	radical SAM domain protein
VU15_RS21395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VU15_RS21420	COG0659	secondary active sulfate transmembrane transporter activity
VU15_RS21425	COG1592	Rubrerythrin
VU15_RS21430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VU15_RS21450	COG0427	acetyl-CoA hydrolase
VU15_RS21460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VU15_RS21470	COG3250	beta-galactosidase activity
VU15_RS21565	COG2177	Part of the ABC transporter FtsEX involved in
VU15_RS21575	COG1968	undecaprenyl-diphosphatase activity
VU15_RS21580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VU15_RS21585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VU15_RS21590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VU15_RS21595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VU15_RS21600	COG1611	Belongs to the LOG family
VU15_RS21615	COG0594	ribonuclease P activity
VU15_RS21630	COG4946	Tricorn protease homolog
VU15_RS21630	COG1506	peptidase
VU15_RS21630	COG0823	Involved in the tonB-independent uptake of proteins
VU15_RS21640	COG3119	arylsulfatase activity
VU15_RS21645	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
VU15_RS21650	COG1028	Short-chain dehydrogenase reductase Sdr
VU15_RS21660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)