locus-tag	class	description
INE73_RS00010	COG0702	epimerase
INE73_RS00015	COG0673	inositol 2-dehydrogenase activity
INE73_RS00055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INE73_RS00060	COG0793	Belongs to the peptidase S41A family
INE73_RS00065	COG2131	deaminase
INE73_RS00075	COG0339	signal peptide processing
INE73_RS00085	COG1970	mechanosensitive ion channel activity
INE73_RS00090	COG0519	Catalyzes the synthesis of GMP from XMP
INE73_RS00090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INE73_RS00100	COG4206	TonB-dependent receptor
INE73_RS00100	COG1629	transport
INE73_RS00110	COG1629	transport
INE73_RS00110	COG4206	TonB-dependent receptor
INE73_RS00115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
INE73_RS00135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INE73_RS00160	COG1242	4 iron, 4 sulfur cluster binding
INE73_RS00170	COG0363	glucosamine-6-phosphate deaminase activity
INE73_RS00180	COG0009	L-threonylcarbamoyladenylate synthase
INE73_RS00190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE73_RS00195	COG0561	phosphatase activity
INE73_RS00210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE73_RS00215	COG2873	o-acetylhomoserine
INE73_RS00270	COG0297	glycogen (starch) synthase activity
INE73_RS00275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INE73_RS00280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INE73_RS00285	COG0543	2 iron, 2 sulfur cluster binding
INE73_RS00295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INE73_RS00300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INE73_RS00305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INE73_RS00310	COG0546	phosphoglycolate phosphatase activity
INE73_RS00315	COG0791	NLP P60 protein
INE73_RS00330	COG0612	Peptidase, M16
INE73_RS00335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
INE73_RS00340	COG1597	lipid kinase activity
INE73_RS00345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE73_RS00355	COG1136	(ABC) transporter
INE73_RS00375	COG2211	Major facilitator Superfamily
INE73_RS00390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE73_RS00405	COG1674	ftsk spoiiie
INE73_RS00415	COG0492	ferredoxin-NADP+ reductase activity
INE73_RS00420	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS00450	COG1234	tRNA 3'-trailer cleavage
INE73_RS00455	COG1595	DNA-templated transcription, initiation
INE73_RS00470	COG3956	TIGRFAM MazG family protein
INE73_RS00480	COG0525	valine-tRNA ligase activity
INE73_RS00485	COG5002	protein histidine kinase activity
INE73_RS00485	COG0784	Response regulator, receiver
INE73_RS00485	COG2205	protein histidine kinase activity
INE73_RS00505	COG4771	TonB-dependent receptor
INE73_RS00520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
INE73_RS00535	COG4771	TonB-dependent receptor
INE73_RS00540	COG0702	epimerase
INE73_RS00545	COG3119	arylsulfatase activity
INE73_RS00550	COG3119	arylsulfatase activity
INE73_RS00570	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
INE73_RS00580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
INE73_RS00600	COG1253	flavin adenine dinucleotide binding
INE73_RS00610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INE73_RS00620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
INE73_RS00660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INE73_RS00670	COG2226	methyltransferase
INE73_RS00715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INE73_RS00725	COG3475	LICD family
INE73_RS00745	COG1215	transferase activity, transferring glycosyl groups
INE73_RS00750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE73_RS00755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE73_RS00770	COG4771	TonB-dependent receptor
INE73_RS00775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INE73_RS00780	COG0563	adenylate kinase activity
INE73_RS00785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE73_RS00790	COG1496	oxidoreductase activity
INE73_RS00810	COG2706	6-phosphogluconolactonase activity
INE73_RS00845	COG1288	antiporter activity
INE73_RS00865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE73_RS00885	COG0564	pseudouridine synthase activity
INE73_RS00900	COG1501	Belongs to the glycosyl hydrolase 31 family
INE73_RS00905	COG1028	Short-chain dehydrogenase reductase Sdr
INE73_RS00970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
INE73_RS01030	COG3550	peptidyl-serine autophosphorylation
INE73_RS01060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
INE73_RS01075	COG3645	SOS response
INE73_RS01100	COG0582	viral genome integration into host DNA
INE73_RS01130	COG1910	domain protein
INE73_RS01150	COG4974	Belongs to the 'phage' integrase family
INE73_RS01160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INE73_RS01165	COG5002	protein histidine kinase activity
INE73_RS01165	COG0784	Response regulator, receiver
INE73_RS01175	COG2176	DNA-directed DNA polymerase activity
INE73_RS01185	COG4864	UPF0365 protein
INE73_RS01200	COG0037	tRNA processing
INE73_RS01210	COG1477	protein flavinylation
INE73_RS01215	COG1971	Probably functions as a manganese efflux pump
INE73_RS01230	COG0463	Glycosyl transferase, family 2
INE73_RS01245	COG0148	phosphopyruvate hydratase activity
INE73_RS01255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INE73_RS01260	COG1082	Xylose isomerase domain protein TIM barrel
INE73_RS01280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INE73_RS01285	COG0193	aminoacyl-tRNA hydrolase activity
INE73_RS01290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INE73_RS01300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INE73_RS01305	COG1862	Preprotein translocase
INE73_RS01350	COG0542	response to heat
INE73_RS01360	COG0583	DNA-binding transcription factor activity
INE73_RS01365	COG2855	membrane
INE73_RS01380	COG1595	DNA-templated transcription, initiation
INE73_RS01395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
INE73_RS01415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INE73_RS01435	COG0443	Heat shock 70 kDa protein
INE73_RS01505	COG0515	serine threonine protein kinase
INE73_RS01505	COG2815	serine threonine protein kinase
INE73_RS01555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INE73_RS01580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
INE73_RS01585	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
INE73_RS01590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE73_RS01605	COG1501	Belongs to the glycosyl hydrolase 31 family
INE73_RS01630	COG4206	TonB-dependent receptor
INE73_RS01630	COG1629	transport
INE73_RS01640	COG1408	metallophosphoesterase
INE73_RS01645	COG1368	sulfuric ester hydrolase activity
INE73_RS01655	COG3634	alkyl hydroperoxide reductase activity
INE73_RS01685	COG1760	l-serine dehydratase
INE73_RS01690	COG0598	Magnesium transport protein CorA
INE73_RS01695	COG1193	negative regulation of DNA recombination
INE73_RS01705	COG4974	Belongs to the 'phage' integrase family
INE73_RS01850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE73_RS01850	COG0551	DNA topoisomerase type I activity
INE73_RS01910	COG4974	Belongs to the 'phage' integrase family
INE73_RS01915	COG1309	transcriptional regulator
INE73_RS01935	COG1063	alcohol dehydrogenase
INE73_RS01950	COG3119	arylsulfatase activity
INE73_RS01960	COG2855	membrane
INE73_RS01965	COG2217	Heavy metal translocating P-type atpase
INE73_RS01975	COG2885	chlorophyll binding
INE73_RS01980	COG3189	MarR family transcriptional regulator
INE73_RS01985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INE73_RS01990	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE73_RS01995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
INE73_RS02010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE73_RS02010	COG4651	solute:proton antiporter activity
INE73_RS02015	COG1280	lysine exporter protein (LysE YggA)
INE73_RS02030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
INE73_RS02040	COG0561	phosphatase activity
INE73_RS02045	COG1169	isochorismate synthase
INE73_RS02050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INE73_RS02065	COG4948	Mandelate Racemase Muconate Lactonizing
INE73_RS02080	COG1082	Xylose isomerase domain protein TIM barrel
INE73_RS02095	COG4771	TonB-dependent receptor
INE73_RS02125	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE73_RS02130	COG0783	Belongs to the Dps family
INE73_RS02135	COG0583	DNA-binding transcription factor activity
INE73_RS02155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INE73_RS02215	COG4804	nuclease activity
INE73_RS02250	COG1253	flavin adenine dinucleotide binding
INE73_RS02255	COG0501	Belongs to the peptidase M48B family
INE73_RS02280	COG2873	o-acetylhomoserine
INE73_RS02285	COG0482	sulfurtransferase activity
INE73_RS02290	COG2197	response regulator
INE73_RS02300	COG1757	Na H antiporter
INE73_RS02315	COG2814	Major facilitator Superfamily
INE73_RS02320	COG4953	penicillin-binding protein 1C
INE73_RS02325	COG2373	Large extracellular alpha-helical protein
INE73_RS02335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INE73_RS02335	COG1918	ferrous iron import across plasma membrane
INE73_RS02400	COG2244	polysaccharide biosynthetic process
INE73_RS02405	COG0562	UDP-galactopyranose mutase
INE73_RS02410	COG1215	transferase activity, transferring glycosyl groups
INE73_RS02425	COG0438	transferase activity, transferring glycosyl groups
INE73_RS02435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE73_RS02440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE73_RS02450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE73_RS02455	COG0471	metal ion transport
INE73_RS02455	COG0490	domain, Protein
INE73_RS02470	COG0346	lactoylglutathione lyase activity
INE73_RS02485	COG0259	pyridoxamine-phosphate oxidase activity
INE73_RS02490	COG1741	Belongs to the pirin family
INE73_RS02505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE73_RS02535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
INE73_RS02545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
INE73_RS02560	COG1595	DNA-templated transcription, initiation
INE73_RS02585	COG0686	Belongs to the AlaDH PNT family
INE73_RS02600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE73_RS02615	COG1629	transport
INE73_RS02630	COG3345	alpha-galactosidase
INE73_RS02645	COG0488	(ABC) transporter
INE73_RS02650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE73_RS02655	COG3059	membrane
INE73_RS02660	COG2207	Transcriptional regulator
INE73_RS02660	COG1917	Cupin 2, conserved barrel domain protein
INE73_RS02665	COG0295	cytidine deaminase activity
INE73_RS02670	COG1388	LysM domain
INE73_RS02670	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE73_RS02680	COG0577	efflux transmembrane transporter activity
INE73_RS02685	COG0577	efflux transmembrane transporter activity
INE73_RS02690	COG0577	efflux transmembrane transporter activity
INE73_RS02700	COG0577	efflux transmembrane transporter activity
INE73_RS02700	COG1136	(ABC) transporter
INE73_RS02715	COG1136	(ABC) transporter
INE73_RS02720	COG0577	efflux transmembrane transporter activity
INE73_RS02720	COG1136	(ABC) transporter
INE73_RS02730	COG1136	(ABC) transporter
INE73_RS02750	COG2205	protein histidine kinase activity
INE73_RS02760	COG2204	response regulator
INE73_RS02825	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INE73_RS02835	COG1088	dTDP-glucose 4,6-dehydratase activity
INE73_RS02890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE73_RS02895	COG1530	ribonuclease E activity
INE73_RS02910	COG3119	arylsulfatase activity
INE73_RS02915	COG0629	single-stranded DNA binding
INE73_RS02975	COG4206	TonB-dependent receptor
INE73_RS02990	COG5002	protein histidine kinase activity
INE73_RS02995	COG0745	RESPONSE REGULATOR receiver
INE73_RS03020	COG0488	(ABC) transporter
INE73_RS03035	COG5492	domain, Protein
INE73_RS03045	COG0436	Aminotransferase
INE73_RS03050	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE73_RS03055	COG1215	transferase activity, transferring glycosyl groups
INE73_RS03060	COG0628	permease
INE73_RS03065	COG3852	Histidine kinase
INE73_RS03080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE73_RS03085	COG0577	efflux transmembrane transporter activity
INE73_RS03085	COG1136	(ABC) transporter
INE73_RS03090	COG0577	efflux transmembrane transporter activity
INE73_RS03095	COG1252	NADH dehydrogenase
INE73_RS03125	COG4771	TonB-dependent receptor
INE73_RS03135	COG1620	l-lactate permease
INE73_RS03140	COG3047	cAMP biosynthetic process
INE73_RS03140	COG2885	chlorophyll binding
INE73_RS03150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE73_RS03155	COG0439	Biotin carboxylase
INE73_RS03160	COG0511	ligase activity, forming carbon-carbon bonds
INE73_RS03165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
INE73_RS03195	COG0508	dehydrogenase complex catalyzes the overall conversion of
INE73_RS03200	COG0022	dehydrogenase e1 component
INE73_RS03205	COG0716	FMN binding
INE73_RS03210	COG2264	protein methyltransferase activity
INE73_RS03225	COG0590	tRNA wobble adenosine to inosine editing
INE73_RS03250	COG0673	inositol 2-dehydrogenase activity
INE73_RS03255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE73_RS03295	COG0698	ribose 5-phosphate isomerase
INE73_RS03300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
INE73_RS03305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INE73_RS03320	COG1482	cell wall glycoprotein biosynthetic process
INE73_RS03340	COG0513	Belongs to the DEAD box helicase family
INE73_RS03345	COG4221	oxidoreductase activity
INE73_RS03360	COG3250	beta-galactosidase activity
INE73_RS03370	COG0471	metal ion transport
INE73_RS03370	COG3273	potassium ion transport
INE73_RS03375	COG0529	Catalyzes the synthesis of activated sulfate
INE73_RS03380	COG0175	sulfate reduction
INE73_RS03425	COG4974	Belongs to the 'phage' integrase family
INE73_RS03475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INE73_RS03480	COG0242	peptide deformylase activity
INE73_RS03495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INE73_RS03500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INE73_RS03505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INE73_RS03510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INE73_RS03520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE73_RS03525	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE73_RS03540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INE73_RS03585	COG1940	carbohydrate kinase activity
INE73_RS03590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE73_RS03600	COG2271	Major facilitator Superfamily
INE73_RS03605	COG2731	YhcH YjgK YiaL family protein
INE73_RS03610	COG1629	transport
INE73_RS03615	COG0702	epimerase
INE73_RS03630	COG1629	transport
INE73_RS03635	COG0702	epimerase
INE73_RS03645	COG1629	transport
INE73_RS03650	COG0702	epimerase
INE73_RS03665	COG4771	TonB-dependent receptor
INE73_RS03670	COG0702	epimerase
INE73_RS03675	COG0702	epimerase
INE73_RS03680	COG4206	TonB-dependent receptor
INE73_RS03680	COG1629	transport
INE73_RS03685	COG4206	TonB-dependent receptor
INE73_RS03685	COG1629	transport
INE73_RS03700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS03720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS03730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS03735	COG3537	Alpha-1,2-mannosidase
INE73_RS03740	COG3250	beta-galactosidase activity
INE73_RS03745	COG1629	transport
INE73_RS03745	COG4206	TonB-dependent receptor
INE73_RS03750	COG0702	epimerase
INE73_RS03755	COG3250	beta-galactosidase activity
INE73_RS03760	COG0484	heat shock protein binding
INE73_RS03765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INE73_RS03770	COG0488	(ABC) transporter
INE73_RS03775	COG1595	DNA-templated transcription, initiation
INE73_RS03830	COG2885	chlorophyll binding
INE73_RS03945	COG2183	response to ionizing radiation
INE73_RS03955	COG0737	Belongs to the 5'-nucleotidase family
INE73_RS03960	COG1956	GAF domain-containing protein
INE73_RS03970	COG4771	TonB-dependent receptor
INE73_RS03995	COG0534	Mate efflux family protein
INE73_RS04005	COG0534	Mate efflux family protein
INE73_RS04015	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
INE73_RS04025	COG0318	PFAM AMP-dependent synthetase and ligase
INE73_RS04030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE73_RS04035	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INE73_RS04070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INE73_RS04105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE73_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
INE73_RS04135	COG1216	Glycosyl transferase, family 2
INE73_RS04135	COG0463	Glycosyl transferase, family 2
INE73_RS04170	COG1086	Polysaccharide biosynthesis protein
INE73_RS04180	COG1091	dTDP-4-dehydrorhamnose reductase activity
INE73_RS04190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE73_RS04195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE73_RS04220	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
INE73_RS04225	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INE73_RS04230	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INE73_RS04235	COG0363	glucosamine-6-phosphate deaminase activity
INE73_RS04255	COG4413	Urea transporter
INE73_RS04295	COG3279	Response regulator of the LytR AlgR family
INE73_RS04305	COG1136	(ABC) transporter
INE73_RS04305	COG0577	efflux transmembrane transporter activity
INE73_RS04310	COG1136	(ABC) transporter
INE73_RS04315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE73_RS04340	COG4884	unkown
INE73_RS04340	COG3831	ATPase activity
INE73_RS04355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INE73_RS04365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE73_RS04370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INE73_RS04375	COG3250	beta-galactosidase activity
INE73_RS04405	COG1704	LemA family
INE73_RS04410	COG1595	DNA-templated transcription, initiation
INE73_RS04420	COG1629	transport
INE73_RS04420	COG4206	TonB-dependent receptor
INE73_RS04430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INE73_RS04435	COG2885	chlorophyll binding
INE73_RS04435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE73_RS04445	COG0697	spore germination
INE73_RS04475	COG0776	regulation of translation
INE73_RS04530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INE73_RS04545	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
INE73_RS04550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INE73_RS04555	COG2814	Major facilitator Superfamily
INE73_RS04560	COG4771	TonB-dependent receptor
INE73_RS04585	COG4771	TonB-dependent receptor
INE73_RS04765	COG0542	response to heat
INE73_RS04800	COG0156	8-amino-7-oxononanoate synthase activity
INE73_RS04885	COG0488	(ABC) transporter
INE73_RS04905	COG0784	Response regulator, receiver
INE73_RS04905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE73_RS04905	COG2205	protein histidine kinase activity
INE73_RS04905	COG2198	Histidine kinase
INE73_RS04930	COG0438	transferase activity, transferring glycosyl groups
INE73_RS04945	COG2244	polysaccharide biosynthetic process
INE73_RS04950	COG1216	Glycosyl transferase, family 2
INE73_RS04950	COG1442	glycosyl transferase family 8
INE73_RS04965	COG1215	transferase activity, transferring glycosyl groups
INE73_RS04995	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE73_RS05000	COG1805	sodium ion transport
INE73_RS05005	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE73_RS05030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INE73_RS05035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE73_RS05045	COG0545	Peptidyl-prolyl cis-trans isomerase
INE73_RS05050	COG1739	Uncharacterized protein family UPF0029
INE73_RS05060	COG0778	Nitroreductase
INE73_RS05065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE73_RS05065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE73_RS05070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INE73_RS05100	COG2217	Heavy metal translocating P-type atpase
INE73_RS05155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE73_RS05160	COG1755	Isoprenylcysteine carboxyl methyltransferase
INE73_RS05170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INE73_RS05185	COG1678	Uncharacterized ACR, COG1678
INE73_RS05205	COG0667	Aldo Keto reductase
INE73_RS05215	COG0656	L-ascorbic acid biosynthetic process
INE73_RS05225	COG0656	L-ascorbic acid biosynthetic process
INE73_RS05240	COG0534	Mate efflux family protein
INE73_RS05245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE73_RS05260	COG1028	Short-chain dehydrogenase reductase Sdr
INE73_RS05280	COG1979	alcohol dehydrogenase
INE73_RS05285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INE73_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
INE73_RS05300	COG0667	Aldo Keto reductase
INE73_RS05315	COG2311	Membrane
INE73_RS05320	COG0667	Aldo Keto reductase
INE73_RS05380	COG4771	TonB-dependent receptor
INE73_RS05405	COG1309	transcriptional regulator
INE73_RS05420	COG1132	(ABC) transporter
INE73_RS05425	COG2205	protein histidine kinase activity
INE73_RS05425	COG3437	response regulator, receiver
INE73_RS05425	COG3850	Histidine kinase
INE73_RS05425	COG4999	Histidine kinase
INE73_RS05440	COG1522	sequence-specific DNA binding
INE73_RS05460	COG3969	phosphoadenosine phosphosulfate
INE73_RS05465	COG1475	DNA binding
INE73_RS05505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE73_RS05510	COG0745	RESPONSE REGULATOR receiver
INE73_RS05525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS05535	COG1629	transport
INE73_RS05535	COG4206	TonB-dependent receptor
INE73_RS05545	COG2425	protein containing a von Willebrand factor type A (vWA) domain
INE73_RS05565	COG1022	Amp-dependent synthetase and ligase
INE73_RS05570	COG3263	regulation of cellular component size
INE73_RS05615	COG0577	efflux transmembrane transporter activity
INE73_RS05615	COG1136	(ABC) transporter
INE73_RS05630	COG0534	Mate efflux family protein
INE73_RS05635	COG1011	Hydrolase
INE73_RS05640	COG0167	dihydroorotate dehydrogenase activity
INE73_RS05650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
INE73_RS05665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INE73_RS05680	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
INE73_RS05690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
INE73_RS05700	COG0356	it plays a direct role in the translocation of protons across the membrane
INE73_RS05705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE73_RS05710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INE73_RS05715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE73_RS05720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INE73_RS05725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INE73_RS05730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE73_RS05735	COG3118	belongs to the thioredoxin family
INE73_RS05755	COG0745	RESPONSE REGULATOR receiver
INE73_RS05760	COG5002	protein histidine kinase activity
INE73_RS05790	COG1120	ATPase activity
INE73_RS05795	COG1091	dTDP-4-dehydrorhamnose reductase activity
INE73_RS05825	COG2202	Pas domain
INE73_RS05825	COG2205	protein histidine kinase activity
INE73_RS05830	COG2759	Belongs to the formate--tetrahydrofolate ligase family
INE73_RS05840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INE73_RS05855	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
INE73_RS05860	COG0540	Belongs to the ATCase OTCase family
INE73_RS05870	COG2431	L-lysine efflux transmembrane transporter activity
INE73_RS05895	COG2837	iron assimilation
INE73_RS05905	COG1629	transport
INE73_RS05905	COG4206	TonB-dependent receptor
INE73_RS05925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
INE73_RS05935	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INE73_RS05955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INE73_RS05960	COG2205	protein histidine kinase activity
INE73_RS06010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INE73_RS06015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE73_RS06025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INE73_RS06035	COG0673	inositol 2-dehydrogenase activity
INE73_RS06045	COG2223	nitrite transmembrane transporter activity
INE73_RS06065	COG0671	phosphoesterase, PA-phosphatase related
INE73_RS06080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
INE73_RS06085	COG0045	succinate-CoA ligase (ADP-forming) activity
INE73_RS06090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INE73_RS06095	COG0351	phosphomethylpyrimidine kinase
INE73_RS06105	COG1070	Carbohydrate kinase
INE73_RS06115	COG0477	Major facilitator Superfamily
INE73_RS06115	COG2814	Major facilitator Superfamily
INE73_RS06125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE73_RS06125	COG3153	acetyltransferase
INE73_RS06130	COG0450	alkyl hydroperoxide reductase
INE73_RS06135	COG0724	RNA recognition motif
INE73_RS06140	COG1858	cytochrome C peroxidase
INE73_RS06145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE73_RS06165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INE73_RS06175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INE73_RS06190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE73_RS06240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE73_RS06250	COG1904	glucuronate isomerase
INE73_RS06280	COG0513	Belongs to the DEAD box helicase family
INE73_RS06285	COG0560	Phosphoserine phosphatase
INE73_RS06285	COG3830	Belongs to the UPF0237 family
INE73_RS06300	COG0343	queuine tRNA-ribosyltransferase activity
INE73_RS06305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
INE73_RS06310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
INE73_RS06345	COG2205	protein histidine kinase activity
INE73_RS06350	COG2204	response regulator
INE73_RS06395	COG1136	(ABC) transporter
INE73_RS06395	COG0577	efflux transmembrane transporter activity
INE73_RS06400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE73_RS06485	COG0156	8-amino-7-oxononanoate synthase activity
INE73_RS06490	COG1597	lipid kinase activity
INE73_RS06495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INE73_RS06520	COG1136	(ABC) transporter
INE73_RS06520	COG0577	efflux transmembrane transporter activity
INE73_RS06545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INE73_RS06575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE73_RS06600	COG0543	2 iron, 2 sulfur cluster binding
INE73_RS06605	COG0167	dihydroorotate dehydrogenase activity
INE73_RS06610	COG0336	Belongs to the RNA methyltransferase TrmD family
INE73_RS06615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INE73_RS06620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE73_RS06660	COG0326	Molecular chaperone. Has ATPase activity
INE73_RS06665	COG0542	response to heat
INE73_RS06710	COG2304	oxidoreductase activity
INE73_RS06725	COG0714	Associated with various cellular activities
INE73_RS06730	COG1652	LysM domain
INE73_RS06740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE73_RS06745	COG0552	protein localization to endoplasmic reticulum
INE73_RS06755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INE73_RS06760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INE73_RS06770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INE73_RS06785	COG0442	prolyl-tRNA aminoacylation
INE73_RS06795	COG0793	Belongs to the peptidase S41A family
INE73_RS06795	COG4946	Tricorn protease homolog
INE73_RS06810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
INE73_RS06815	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
INE73_RS06825	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
INE73_RS06835	COG1492	cobalamin metabolic process
INE73_RS06850	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
INE73_RS06880	COG2096	Adenosyltransferase
INE73_RS06885	COG1797	cobyrinic acid a,c-diamide synthase activity
INE73_RS06900	COG2966	Psort location CytoplasmicMembrane, score
INE73_RS06915	COG4771	TonB-dependent receptor
INE73_RS06925	COG4774	siderophore transport
INE73_RS06935	COG1429	ligase activity, forming nitrogen-metal bonds
INE73_RS06970	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
INE73_RS07040	COG0352	thiamine-phosphate diphosphorylase activity
INE73_RS07045	COG2022	thiamine diphosphate biosynthetic process
INE73_RS07050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
INE73_RS07070	COG0352	thiamine-phosphate diphosphorylase activity
INE73_RS07085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INE73_RS07085	COG0574	Belongs to the PEP-utilizing enzyme family
INE73_RS07090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INE73_RS07095	COG0564	pseudouridine synthase activity
INE73_RS07110	COG0024	Methionine aminopeptidase
INE73_RS07135	COG0481	GTPase activity
INE73_RS07155	COG0708	Exodeoxyribonuclease III
INE73_RS07160	COG1914	H( )-stimulated, divalent metal cation uptake system
INE73_RS07175	COG0217	transcriptional regulatory protein
INE73_RS07180	COG0072	phenylalanine-tRNA ligase activity
INE73_RS07180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE73_RS07185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE73_RS07190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE73_RS07195	COG1215	transferase activity, transferring glycosyl groups
INE73_RS07215	COG1216	Glycosyl transferase, family 2
INE73_RS07225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE73_RS07230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
INE73_RS07235	COG0673	inositol 2-dehydrogenase activity
INE73_RS07245	COG2244	polysaccharide biosynthetic process
INE73_RS07275	COG0305	Participates in initiation and elongation during chromosome replication
INE73_RS07295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INE73_RS07300	COG4657	Part of a membrane complex involved in electron transport
INE73_RS07305	COG4660	Part of a membrane complex involved in electron transport
INE73_RS07310	COG4659	FMN binding
INE73_RS07315	COG4658	electron transport chain
INE73_RS07320	COG4656	Part of a membrane complex involved in electron transport
INE73_RS07345	COG0504	CTP synthase activity
INE73_RS07350	COG0706	membrane insertase activity
INE73_RS07355	COG0534	Mate efflux family protein
INE73_RS07360	COG1506	peptidase
INE73_RS07360	COG0823	Involved in the tonB-independent uptake of proteins
INE73_RS07375	COG1695	Transcriptional regulator
INE73_RS07390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INE73_RS07400	COG3942	CHAP domain
INE73_RS07400	COG1388	LysM domain
INE73_RS07430	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE73_RS07435	COG0556	nucleotide-excision repair
INE73_RS07440	COG2949	membrane
INE73_RS07450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INE73_RS07460	COG4999	Histidine kinase
INE73_RS07460	COG3850	Histidine kinase
INE73_RS07460	COG3437	response regulator, receiver
INE73_RS07460	COG2205	protein histidine kinase activity
INE73_RS07470	COG0842	Transport permease protein
INE73_RS07475	COG1131	(ABC) transporter
INE73_RS07505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE73_RS07510	COG0505	Belongs to the CarA family
INE73_RS07520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INE73_RS07530	COG0367	asparagine synthase
INE73_RS07565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INE73_RS07575	COG1979	alcohol dehydrogenase
INE73_RS07580	COG0133	tryptophan synthase activity
INE73_RS07585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INE73_RS07590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INE73_RS07590	COG0512	Glutamine amidotransferase of anthranilate synthase
INE73_RS07600	COG0134	indole-3-glycerol-phosphate synthase activity
INE73_RS07605	COG0135	phosphoribosylanthranilate isomerase activity
INE73_RS07610	COG0159	tryptophan synthase activity
INE73_RS07615	COG0252	asparaginase activity
INE73_RS07630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE73_RS07640	COG0110	maltose O-acetyltransferase activity
INE73_RS07645	COG2197	response regulator
INE73_RS07655	COG0138	bifunctional purine biosynthesis protein purh
INE73_RS07660	COG0716	FMN binding
INE73_RS07685	COG1858	cytochrome C peroxidase
INE73_RS07695	COG4771	TonB-dependent receptor
INE73_RS07710	COG2814	Major facilitator Superfamily
INE73_RS07715	COG1566	PFAM secretion protein HlyD family protein
INE73_RS07745	COG4771	TonB-dependent receptor
INE73_RS07770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INE73_RS07775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INE73_RS07785	COG2966	Psort location CytoplasmicMembrane, score
INE73_RS07790	COG3610	response to peptide
INE73_RS07805	COG1609	Transcriptional regulator
INE73_RS07815	COG1733	regulation of RNA biosynthetic process
INE73_RS07820	COG2198	Histidine kinase
INE73_RS07820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE73_RS07820	COG0784	Response regulator, receiver
INE73_RS07820	COG2205	protein histidine kinase activity
INE73_RS07835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INE73_RS07840	COG1690	Belongs to the RtcB family
INE73_RS07860	COG0228	four-way junction DNA binding
INE73_RS07875	COG0724	RNA recognition motif
INE73_RS07885	COG1177	transmembrane transport
INE73_RS07890	COG1176	ABC-type spermidine putrescine transport system, permease component I
INE73_RS07895	COG3842	ATPase activity
INE73_RS07900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE73_RS07910	COG0058	SHG alpha-glucan phosphorylase activity
INE73_RS07920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE73_RS07940	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
INE73_RS07985	COG0745	RESPONSE REGULATOR receiver
INE73_RS07990	COG5002	protein histidine kinase activity
INE73_RS08015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INE73_RS08020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INE73_RS08030	COG4948	Mandelate Racemase Muconate Lactonizing
INE73_RS08045	COG1295	ribonuclease BN
INE73_RS08050	COG0778	Nitroreductase
INE73_RS08060	COG0704	Plays a role in the regulation of phosphate uptake
INE73_RS08065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INE73_RS08070	COG0581	inorganic phosphate transmembrane transporter activity
INE73_RS08075	COG0573	inorganic phosphate transmembrane transporter activity
INE73_RS08085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE73_RS08105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
INE73_RS08140	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE73_RS08195	COG0297	glycogen (starch) synthase activity
INE73_RS08195	COG0438	transferase activity, transferring glycosyl groups
INE73_RS08245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
INE73_RS08295	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
INE73_RS08330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INE73_RS08335	COG0167	dihydroorotate dehydrogenase activity
INE73_RS08400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE73_RS08400	COG4191	Histidine kinase
INE73_RS08415	COG2172	sigma factor antagonist activity
INE73_RS08425	COG2208	phosphoserine phosphatase activity
INE73_RS08445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
INE73_RS08465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE73_RS08470	COG0497	DNA recombination
INE73_RS08480	COG2176	DNA-directed DNA polymerase activity
INE73_RS08480	COG5002	protein histidine kinase activity
INE73_RS08485	COG0592	DNA-directed DNA polymerase activity
INE73_RS08500	COG0321	lipoyl(octanoyl) transferase activity
INE73_RS08500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE73_RS08515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE73_RS08520	COG0156	8-amino-7-oxononanoate synthase activity
INE73_RS08610	COG0019	diaminopimelate decarboxylase activity
INE73_RS08615	COG0527	aspartate kinase activity
INE73_RS08620	COG2884	Cell division ATP-binding protein ftsE
INE73_RS08625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INE73_RS08625	COG0140	phosphoribosyl-ATP diphosphatase activity
INE73_RS08635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INE73_RS08655	COG3586	endonuclease activity
INE73_RS08685	COG1472	Belongs to the glycosyl hydrolase 3 family
INE73_RS08690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
INE73_RS08700	COG5012	cobalamin binding
INE73_RS08710	COG1472	Belongs to the glycosyl hydrolase 3 family
INE73_RS08715	COG0702	epimerase
INE73_RS08720	COG4771	TonB-dependent receptor
INE73_RS08735	COG0693	protein deglycase activity
INE73_RS08745	COG0494	nUDIX hydrolase
INE73_RS08750	COG1401	restriction endodeoxyribonuclease activity
INE73_RS08805	COG1917	Cupin 2, conserved barrel domain protein
INE73_RS08805	COG4977	sequence-specific DNA binding
INE73_RS08810	COG2814	Major facilitator Superfamily
INE73_RS08815	COG1028	Short-chain dehydrogenase reductase Sdr
INE73_RS08820	COG2207	Transcriptional regulator
INE73_RS08835	COG1090	epimerase
INE73_RS08865	COG0561	phosphatase activity
INE73_RS08870	COG1629	transport
INE73_RS08870	COG4206	TonB-dependent receptor
INE73_RS08920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE73_RS08930	COG0363	glucosamine-6-phosphate deaminase activity
INE73_RS08970	COG1032	radical SAM domain protein
INE73_RS08975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INE73_RS08980	COG0463	Glycosyl transferase, family 2
INE73_RS08985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INE73_RS08995	COG0646	methionine synthase
INE73_RS08995	COG1410	methionine synthase
INE73_RS09040	COG1408	metallophosphoesterase
INE73_RS09045	COG1132	(ABC) transporter
INE73_RS09050	COG1132	(ABC) transporter
INE73_RS09065	COG0420	3'-5' exonuclease activity
INE73_RS09085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE73_RS09090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE73_RS09100	COG0681	Belongs to the peptidase S26 family
INE73_RS09260	COG0551	DNA topoisomerase type I activity
INE73_RS09260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE73_RS09270	COG4974	Belongs to the 'phage' integrase family
INE73_RS09475	COG2003	Belongs to the UPF0758 family
INE73_RS09495	COG1475	DNA binding
INE73_RS09545	COG1733	regulation of RNA biosynthetic process
INE73_RS09565	COG4974	Belongs to the 'phage' integrase family
INE73_RS09580	COG0641	radical SAM
INE73_RS09585	COG3591	Belongs to the peptidase S1B family
INE73_RS09590	COG3591	Belongs to the peptidase S1B family
INE73_RS09625	COG1592	Rubrerythrin
INE73_RS09625	COG1773	rubredoxin
INE73_RS09635	COG3152	Membrane
INE73_RS09640	COG0339	signal peptide processing
INE73_RS09645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INE73_RS09645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE73_RS09655	COG4206	TonB-dependent receptor
INE73_RS09655	COG1629	transport
INE73_RS09670	COG0131	Imidazoleglycerol-phosphate dehydratase
INE73_RS09670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
INE73_RS09680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INE73_RS09685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INE73_RS09695	COG1741	Belongs to the pirin family
INE73_RS09700	COG4232	protein-disulfide reductase activity
INE73_RS09710	COG0572	uridine kinase
INE73_RS09720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE73_RS09730	COG0646	methionine synthase
INE73_RS09730	COG1410	methionine synthase
INE73_RS09735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INE73_RS09770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE73_RS09780	COG1295	ribonuclease BN
INE73_RS09800	COG2205	protein histidine kinase activity
INE73_RS09800	COG2202	Pas domain
INE73_RS09805	COG2205	protein histidine kinase activity
INE73_RS09805	COG2202	Pas domain
INE73_RS09810	COG0534	Mate efflux family protein
INE73_RS09815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INE73_RS09820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE73_RS09825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INE73_RS09830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE73_RS09890	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INE73_RS09930	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE73_RS09940	COG0668	transmembrane transport
INE73_RS09955	COG3250	beta-galactosidase activity
INE73_RS09965	COG3119	arylsulfatase activity
INE73_RS09970	COG3119	arylsulfatase activity
INE73_RS09975	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS09980	COG0745	RESPONSE REGULATOR receiver
INE73_RS09980	COG2205	protein histidine kinase activity
INE73_RS09980	COG3292	Two component regulator propeller
INE73_RS09985	COG1830	Aldolase
INE73_RS09990	COG0588	phosphoglycerate mutase activity
INE73_RS10000	COG1119	ATPase activity
INE73_RS10005	COG3119	arylsulfatase activity
INE73_RS10010	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS10020	COG4206	TonB-dependent receptor
INE73_RS10020	COG1629	transport
INE73_RS10030	COG1595	DNA-templated transcription, initiation
INE73_RS10035	COG1523	belongs to the glycosyl hydrolase 13 family
INE73_RS10040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INE73_RS10060	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INE73_RS10070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INE73_RS10075	COG0126	phosphoglycerate kinase activity
INE73_RS10090	COG2311	Membrane
INE73_RS10150	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE73_RS10380	COG1476	TRANSCRIPTIONal
INE73_RS10410	COG0305	Participates in initiation and elongation during chromosome replication
INE73_RS10420	COG1061	Type III restriction enzyme res subunit
INE73_RS10530	COG0424	maF-like protein
INE73_RS10535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
INE73_RS10550	COG0778	Nitroreductase
INE73_RS10555	COG0288	reversible hydration of carbon dioxide
INE73_RS10570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE73_RS10580	COG0511	ligase activity, forming carbon-carbon bonds
INE73_RS10580	COG5016	pyruvate
INE73_RS10585	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
INE73_RS10600	COG0366	Alpha amylase catalytic
INE73_RS10620	COG0191	fructose-bisphosphate aldolase activity
INE73_RS10630	COG0254	rRNA binding
INE73_RS10650	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE73_RS10655	COG4206	TonB-dependent receptor
INE73_RS10655	COG1629	transport
INE73_RS10660	COG1609	Transcriptional regulator
INE73_RS10670	COG1554	hydrolase, family 65, central catalytic
INE73_RS10675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE73_RS10695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INE73_RS10695	COG0047	phosphoribosylformylglycinamidine synthase activity
INE73_RS10700	COG0745	RESPONSE REGULATOR receiver
INE73_RS10700	COG2205	protein histidine kinase activity
INE73_RS10700	COG3292	Two component regulator propeller
INE73_RS10715	COG1649	PFAM Uncharacterised BCR, COG1649
INE73_RS10735	COG1966	Carbon starvation protein
INE73_RS10740	COG1649	PFAM Uncharacterised BCR, COG1649
INE73_RS10745	COG2205	protein histidine kinase activity
INE73_RS10745	COG0784	Response regulator, receiver
INE73_RS10775	COG2113	Glycine betaine
INE73_RS10780	COG4176	ABC-type proline glycine betaine transport system permease component
INE73_RS10795	COG0745	RESPONSE REGULATOR receiver
INE73_RS10795	COG2205	protein histidine kinase activity
INE73_RS10795	COG3292	Two component regulator propeller
INE73_RS10800	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
INE73_RS10800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INE73_RS10810	COG1621	beta-fructofuranosidase activity
INE73_RS10835	COG0738	Major facilitator superfamily
INE73_RS10850	COG1752	Esterase of the alpha-beta hydrolase superfamily
INE73_RS10855	COG0475	glutathione-regulated potassium exporter activity
INE73_RS10880	COG3015	lipoprotein NlpE involved in copper resistance
INE73_RS10900	COG1917	Cupin 2, conserved barrel domain protein
INE73_RS10900	COG4977	sequence-specific DNA binding
INE73_RS10925	COG4771	TonB-dependent receptor
INE73_RS10930	COG0702	epimerase
INE73_RS10945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INE73_RS10965	COG0484	heat shock protein binding
INE73_RS10975	COG2194	sulfuric ester hydrolase activity
INE73_RS10985	COG3118	belongs to the thioredoxin family
INE73_RS10985	COG0492	ferredoxin-NADP+ reductase activity
INE73_RS11015	COG0028	Belongs to the TPP enzyme family
INE73_RS11040	COG0459	protein refolding
INE73_RS11045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INE73_RS11085	COG2326	polyphosphate kinase activity
INE73_RS11115	COG3537	Alpha-1,2-mannosidase
INE73_RS11120	COG1506	peptidase
INE73_RS11120	COG0823	Involved in the tonB-independent uptake of proteins
INE73_RS11150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INE73_RS11190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INE73_RS11200	COG0671	phosphoesterase, PA-phosphatase related
INE73_RS11215	COG0702	epimerase
INE73_RS11220	COG4771	TonB-dependent receptor
INE73_RS11240	COG0463	Glycosyl transferase, family 2
INE73_RS11255	COG0066	3-isopropylmalate dehydratase activity
INE73_RS11260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INE73_RS11265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INE73_RS11315	COG0616	signal peptide processing
INE73_RS11325	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
INE73_RS11330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
INE73_RS11520	COG1192	Involved in chromosome partitioning
INE73_RS11550	COG2205	protein histidine kinase activity
INE73_RS11550	COG0784	Response regulator, receiver
INE73_RS11615	COG0438	transferase activity, transferring glycosyl groups
INE73_RS11650	COG1442	glycosyl transferase family 8
INE73_RS11650	COG1216	Glycosyl transferase, family 2
INE73_RS11675	COG4372	Transposase
INE73_RS11755	COG0551	DNA topoisomerase type I activity
INE73_RS11755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE73_RS11825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INE73_RS11835	COG4974	Belongs to the 'phage' integrase family
INE73_RS11910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INE73_RS11920	COG0546	phosphoglycolate phosphatase activity
INE73_RS11935	COG2207	Transcriptional regulator
INE73_RS11940	COG2205	protein histidine kinase activity
INE73_RS11940	COG3292	Two component regulator propeller
INE73_RS11940	COG0745	RESPONSE REGULATOR receiver
INE73_RS11945	COG4948	Mandelate Racemase Muconate Lactonizing
INE73_RS11965	COG0702	epimerase
INE73_RS11970	COG4206	TonB-dependent receptor
INE73_RS11970	COG1629	transport
INE73_RS12000	COG1917	Cupin 2, conserved barrel domain protein
INE73_RS12000	COG2207	Transcriptional regulator
INE73_RS12015	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
INE73_RS12025	COG3011	Protein conserved in bacteria
INE73_RS12035	COG1028	Short-chain dehydrogenase reductase Sdr
INE73_RS12100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
INE73_RS12110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE73_RS12110	COG4651	solute:proton antiporter activity
INE73_RS12115	COG0439	Biotin carboxylase
INE73_RS12120	COG5016	pyruvate
INE73_RS12120	COG0511	ligase activity, forming carbon-carbon bonds
INE73_RS12125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE73_RS12130	COG1335	isochorismatase
INE73_RS12140	COG0517	IMP dehydrogenase activity
INE73_RS12140	COG0516	GMP reductase activity
INE73_RS12155	COG2207	Transcriptional regulator
INE73_RS12160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE73_RS12175	COG2873	o-acetylhomoserine
INE73_RS12235	COG2217	Heavy metal translocating P-type atpase
INE73_RS12245	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE73_RS12255	COG0741	lytic transglycosylase activity
INE73_RS12255	COG1388	LysM domain
INE73_RS12260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INE73_RS12265	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE73_RS12265	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE73_RS12275	COG1285	pathogenesis
INE73_RS12295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INE73_RS12295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INE73_RS12310	COG1115	amino acid carrier protein
INE73_RS12320	COG1509	lysine 2,3-aminomutase activity
INE73_RS12325	COG2233	PERMEase
INE73_RS12340	COG1393	Belongs to the ArsC family
INE73_RS12350	COG1629	transport
INE73_RS12350	COG4206	TonB-dependent receptor
INE73_RS12365	COG4589	Belongs to the CDS family
INE73_RS12375	COG2304	oxidoreductase activity
INE73_RS12385	COG0351	phosphomethylpyrimidine kinase
INE73_RS12395	COG1139	Iron-sulfur cluster binding protein
INE73_RS12400	COG0247	lactate metabolic process
INE73_RS12405	COG0602	queuosine metabolic process
INE73_RS12415	COG2832	Protein of unknown function (DUF454)
INE73_RS12420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE73_RS12435	COG3142	Participates in the control of copper homeostasis
INE73_RS12440	COG1418	mRNA catabolic process
INE73_RS12465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INE73_RS12480	COG4771	TonB-dependent receptor
INE73_RS12590	COG0617	tRNA 3'-terminal CCA addition
INE73_RS12590	COG0517	IMP dehydrogenase activity
INE73_RS12590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INE73_RS12615	COG0612	Peptidase, M16
INE73_RS12625	COG1278	Cold shock
INE73_RS12650	COG0438	transferase activity, transferring glycosyl groups
INE73_RS12660	COG1216	Glycosyl transferase, family 2
INE73_RS12660	COG1442	glycosyl transferase family 8
INE73_RS12680	COG3958	Transketolase
INE73_RS12685	COG3959	Transketolase, thiamine diphosphate binding domain
INE73_RS12700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
INE73_RS12710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE73_RS12760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
INE73_RS12795	COG0632	four-way junction helicase activity
INE73_RS12800	COG0673	inositol 2-dehydrogenase activity
INE73_RS12805	COG1272	protein, Hemolysin III
INE73_RS12810	COG1328	CTP reductase activity
INE73_RS12820	COG2814	Major facilitator Superfamily
INE73_RS12830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE73_RS12840	COG0750	zinc metalloprotease
INE73_RS12855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INE73_RS12860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INE73_RS12870	COG1214	PFAM Peptidase M22, glycoprotease
INE73_RS12890	COG0194	GDP metabolic process
INE73_RS12895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INE73_RS12900	COG1408	metallophosphoesterase
INE73_RS12905	COG1575	Belongs to the MenA family. Type 1 subfamily
INE73_RS12910	COG1088	dTDP-glucose 4,6-dehydratase activity
INE73_RS12915	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INE73_RS12925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INE73_RS12935	COG2204	response regulator
INE73_RS12940	COG0488	(ABC) transporter
INE73_RS13010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INE73_RS13020	COG1522	sequence-specific DNA binding
INE73_RS13045	COG0811	peptide transport
INE73_RS13055	COG0084	hydrolase, TatD family'
INE73_RS13070	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
INE73_RS13075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INE73_RS13080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INE73_RS13085	COG0205	6-phosphofructokinase activity
INE73_RS13105	COG0372	Belongs to the citrate synthase family
INE73_RS13110	COG0538	isocitrate dehydrogenase activity
INE73_RS13120	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE73_RS13130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INE73_RS13155	COG0129	dihydroxy-acid dehydratase activity
INE73_RS13180	COG2885	chlorophyll binding
INE73_RS13200	COG3681	Belongs to the UPF0597 family
INE73_RS13245	COG0702	epimerase
INE73_RS13250	COG4771	TonB-dependent receptor
INE73_RS13265	COG0702	epimerase
INE73_RS13270	COG1629	transport
INE73_RS13270	COG4206	TonB-dependent receptor
INE73_RS13345	COG0358	DNA primase activity
INE73_RS13470	COG0784	Response regulator, receiver
INE73_RS13470	COG2205	protein histidine kinase activity
INE73_RS13470	COG2198	Histidine kinase
INE73_RS13470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE73_RS13490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE73_RS13490	COG0551	DNA topoisomerase type I activity
INE73_RS13520	COG4974	Belongs to the 'phage' integrase family
INE73_RS13590	COG4974	Belongs to the 'phage' integrase family
INE73_RS13595	COG3291	Pkd domain containing protein
INE73_RS13595	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS13605	COG4771	TonB-dependent receptor
INE73_RS13620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INE73_RS13655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE73_RS13655	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE73_RS13660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE73_RS13695	COG0534	Mate efflux family protein
INE73_RS13700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INE73_RS13705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INE73_RS13710	COG0166	Belongs to the GPI family
INE73_RS13720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE73_RS13730	COG2502	aspartate--ammonia ligase
INE73_RS13735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INE73_RS13750	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS13765	COG0860	N-Acetylmuramoyl-L-alanine amidase
INE73_RS13775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INE73_RS13790	COG1640	4-alpha-glucanotransferase
INE73_RS13800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INE73_RS13805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE73_RS13825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE73_RS13830	COG1022	Amp-dependent synthetase and ligase
INE73_RS13850	COG0359	binds to the 23S rRNA
INE73_RS13855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INE73_RS13860	COG0360	Binds together with S18 to 16S ribosomal RNA
INE73_RS13885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE73_RS13890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INE73_RS13910	COG4771	TonB-dependent receptor
INE73_RS13925	COG2431	L-lysine efflux transmembrane transporter activity
INE73_RS13950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE73_RS13955	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
INE73_RS13960	COG0386	Belongs to the glutathione peroxidase family
INE73_RS13980	COG3275	phosphorelay sensor kinase activity
INE73_RS13985	COG3279	Response regulator of the LytR AlgR family
INE73_RS14005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INE73_RS14020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE73_RS14030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INE73_RS14035	COG0658	competence protein
INE73_RS14040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INE73_RS14045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INE73_RS14055	COG0009	L-threonylcarbamoyladenylate synthase
INE73_RS14090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE73_RS14115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
INE73_RS14145	COG1216	Glycosyl transferase, family 2
INE73_RS14150	COG2089	acid synthase
INE73_RS14155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
INE73_RS14160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
INE73_RS14175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE73_RS14180	COG1086	Polysaccharide biosynthesis protein
INE73_RS14190	COG1086	Polysaccharide biosynthesis protein
INE73_RS14225	COG2818	Glycosylase
INE73_RS14235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INE73_RS14235	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INE73_RS14240	COG0514	ATP-dependent DNA helicase (RecQ)
INE73_RS14250	COG2271	Major facilitator Superfamily
INE73_RS14265	COG0702	epimerase
INE73_RS14270	COG4771	TonB-dependent receptor
INE73_RS14275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE73_RS14280	COG2186	Transcriptional regulator
INE73_RS14290	COG0436	Aminotransferase
INE73_RS14295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
INE73_RS14305	COG0358	DNA primase activity
INE73_RS14310	COG3119	arylsulfatase activity
INE73_RS14325	COG4206	TonB-dependent receptor
INE73_RS14325	COG1629	transport
INE73_RS14340	COG0302	gtp cyclohydrolase
INE73_RS14360	COG0739	heme binding
INE73_RS14365	COG0105	UTP biosynthetic process
INE73_RS14370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INE73_RS14395	COG0811	peptide transport
INE73_RS14405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INE73_RS14455	COG1629	transport
INE73_RS14490	COG0039	L-malate dehydrogenase activity
INE73_RS14520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE73_RS14535	COG4948	Mandelate Racemase Muconate Lactonizing
INE73_RS14555	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
INE73_RS14560	COG3118	belongs to the thioredoxin family
INE73_RS14565	COG0489	protein tyrosine kinase activity
INE73_RS14580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE73_RS14585	COG1722	exodeoxyribonuclease VII activity
INE73_RS14590	COG1570	exodeoxyribonuclease VII activity
INE73_RS14600	COG0482	sulfurtransferase activity
INE73_RS14630	COG0179	Fumarylacetoacetate (FAA) hydrolase
INE73_RS14635	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
INE73_RS14645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INE73_RS14650	COG0052	Belongs to the universal ribosomal protein uS2 family
INE73_RS14655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INE73_RS14660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INE73_RS14675	COG0017	Asparaginyl-tRNA synthetase
INE73_RS14680	COG1187	pseudouridine synthase activity
INE73_RS14710	COG0110	maltose O-acetyltransferase activity
INE73_RS14720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS14775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE73_RS14810	COG1216	Glycosyl transferase, family 2
INE73_RS14810	COG1442	glycosyl transferase family 8
INE73_RS14835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
INE73_RS14855	COG0438	transferase activity, transferring glycosyl groups
INE73_RS14910	COG4680	protein conserved in bacteria
INE73_RS14920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INE73_RS14935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE73_RS14950	COG0516	GMP reductase activity
INE73_RS14950	COG0517	IMP dehydrogenase activity
INE73_RS14955	COG0514	ATP-dependent DNA helicase (RecQ)
INE73_RS14960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INE73_RS14975	COG0724	RNA recognition motif
INE73_RS14985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
INE73_RS14990	COG1127	ABC transporter
INE73_RS14995	COG2197	response regulator
INE73_RS15000	COG1160	GTP binding
INE73_RS15005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INE73_RS15010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE73_RS15050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INE73_RS15055	COG0470	DNA polymerase III
INE73_RS15060	COG1774	PSP1 C-terminal conserved region
INE73_RS15070	COG0772	Belongs to the SEDS family
INE73_RS15085	COG1792	Involved in formation and maintenance of cell shape
INE73_RS15095	COG0138	bifunctional purine biosynthesis protein purh
INE73_RS15100	COG3590	peptidase
INE73_RS15105	COG0488	(ABC) transporter
INE73_RS15130	COG2205	protein histidine kinase activity
INE73_RS15130	COG0784	Response regulator, receiver
INE73_RS15135	COG0534	Mate efflux family protein
INE73_RS15140	COG0612	Peptidase, M16
INE73_RS15160	COG0564	pseudouridine synthase activity
INE73_RS15215	COG1131	(ABC) transporter
INE73_RS15235	COG2312	Erythromycin esterase
INE73_RS15280	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
INE73_RS15300	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
INE73_RS15315	COG1696	Membrane protein involved in D-alanine export
INE73_RS15355	COG2986	histidine ammonia-lyase
INE73_RS15365	COG1228	amidohydrolase
INE73_RS15375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
INE73_RS15400	COG0203	ribosomal protein L17
INE73_RS15405	COG0202	RNA polymerase activity
INE73_RS15410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INE73_RS15415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
INE73_RS15420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INE73_RS15425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INE73_RS15430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INE73_RS15445	COG0200	Binds to the 23S rRNA
INE73_RS15450	COG1841	ribosomal large subunit assembly
INE73_RS15455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INE73_RS15460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INE73_RS15465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INE73_RS15470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INE73_RS15475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INE73_RS15480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INE73_RS15485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INE73_RS15490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INE73_RS15495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INE73_RS15500	COG0255	Belongs to the universal ribosomal protein uL29 family
INE73_RS15505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INE73_RS15510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INE73_RS15515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INE73_RS15520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INE73_RS15525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INE73_RS15530	COG0089	rRNA binding
INE73_RS15535	COG0088	Forms part of the polypeptide exit tunnel
INE73_RS15540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INE73_RS15545	COG0051	transcription antitermination factor activity, RNA binding
INE73_RS15550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE73_RS15555	COG0049	tRNA binding
INE73_RS15560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INE73_RS15590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INE73_RS15595	COG0085	RNA polymerase activity
INE73_RS15600	COG0222	ribosome binding
INE73_RS15605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INE73_RS15610	COG0081	regulation of translation
INE73_RS15615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INE73_RS15660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
INE73_RS15665	COG4974	Belongs to the 'phage' integrase family
INE73_RS15670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
INE73_RS15680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
INE73_RS15690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE73_RS15695	COG1480	7TM receptor with intracellular HD hydrolase
INE73_RS15700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INE73_RS15710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INE73_RS15730	COG1027	Aspartate ammonia-lyase
INE73_RS15735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
INE73_RS15740	COG0252	asparaginase activity
INE73_RS15755	COG2096	Adenosyltransferase
INE73_RS15800	COG0657	acetylesterase activity
INE73_RS15800	COG2755	lipolytic protein G-D-S-L family
INE73_RS15810	COG3275	phosphorelay sensor kinase activity
INE73_RS15815	COG3279	Response regulator of the LytR AlgR family
INE73_RS15830	COG4206	TonB-dependent receptor
INE73_RS15850	COG2197	response regulator
INE73_RS15865	COG2207	Transcriptional regulator
INE73_RS15865	COG0662	Cupin 2, conserved barrel domain protein
INE73_RS15870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INE73_RS15900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
INE73_RS15925	COG4974	Belongs to the 'phage' integrase family
INE73_RS16005	COG0358	DNA primase activity
INE73_RS16025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE73_RS16050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INE73_RS16060	COG1185	polyribonucleotide nucleotidyltransferase activity
INE73_RS16075	COG4771	TonB-dependent receptor
INE73_RS16100	COG3426	butyrate kinase activity
INE73_RS16105	COG0280	phosphate acetyltransferase
INE73_RS16115	COG1619	proteins homologs of microcin C7 resistance protein MccF
INE73_RS16120	COG2234	aminopeptidase activity
INE73_RS16125	COG2166	iron-sulfur cluster assembly
INE73_RS16130	COG3655	Transcriptional regulator
INE73_RS16140	COG1266	CAAX protease self-immunity
INE73_RS16145	COG0196	riboflavin kinase activity
INE73_RS16150	COG1011	Hydrolase
INE73_RS16155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INE73_RS16165	COG1773	rubredoxin
INE73_RS16170	COG1283	sodium-dependent phosphate transmembrane transporter activity
INE73_RS16205	COG0006	proline dipeptidase activity
INE73_RS16220	COG0509	glycine decarboxylation via glycine cleavage system
INE73_RS16225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INE73_RS16250	COG0702	epimerase
INE73_RS16255	COG4771	TonB-dependent receptor
INE73_RS16270	COG0793	Belongs to the peptidase S41A family
INE73_RS16275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE73_RS16310	COG4771	TonB-dependent receptor
INE73_RS16320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INE73_RS16325	COG1882	Formate acetyltransferase
INE73_RS16330	COG0477	Major facilitator Superfamily
INE73_RS16330	COG2814	Major facilitator Superfamily
INE73_RS16350	COG1040	competence protein
INE73_RS16355	COG0483	inositol monophosphate 1-phosphatase activity
INE73_RS16365	COG3345	alpha-galactosidase
INE73_RS16390	COG3475	LICD family
INE73_RS16395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE73_RS16405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
INE73_RS16425	COG1442	glycosyl transferase family 8
INE73_RS16495	COG0018	arginyl-trna synthetase
INE73_RS16520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INE73_RS16525	COG0776	regulation of translation
INE73_RS16560	COG1609	Transcriptional regulator
INE73_RS16560	COG2207	Transcriptional regulator
INE73_RS16575	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE73_RS16575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE73_RS16580	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE73_RS16590	COG0584	glycerophosphoryl diester phosphodiesterase
INE73_RS16595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INE73_RS16600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INE73_RS16605	COG1629	transport
INE73_RS16605	COG4206	TonB-dependent receptor
INE73_RS16615	COG1629	transport
INE73_RS16645	COG1629	transport
INE73_RS16655	COG1217	gtp-binding protein TYPA
INE73_RS16660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INE73_RS16670	COG0318	PFAM AMP-dependent synthetase and ligase
INE73_RS16675	COG5002	protein histidine kinase activity
INE73_RS16675	COG0784	Response regulator, receiver
INE73_RS16675	COG2205	protein histidine kinase activity
INE73_RS16690	COG3119	arylsulfatase activity
INE73_RS16700	COG4206	TonB-dependent receptor
INE73_RS16700	COG1629	transport
INE73_RS16715	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE73_RS16720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INE73_RS16735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
INE73_RS16740	COG4974	Belongs to the 'phage' integrase family
INE73_RS16750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE73_RS16755	COG0606	chelatase, subunit chli
INE73_RS16775	COG2205	protein histidine kinase activity
INE73_RS16775	COG3292	Two component regulator propeller
INE73_RS16775	COG0745	RESPONSE REGULATOR receiver
INE73_RS16825	COG0438	transferase activity, transferring glycosyl groups
INE73_RS16850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INE73_RS16855	COG0438	transferase activity, transferring glycosyl groups
INE73_RS16865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INE73_RS16870	COG0545	Peptidyl-prolyl cis-trans isomerase
INE73_RS16875	COG0545	Peptidyl-prolyl cis-trans isomerase
INE73_RS16880	COG1522	sequence-specific DNA binding
INE73_RS16900	COG3275	phosphorelay sensor kinase activity
INE73_RS16975	COG1629	transport
INE73_RS16975	COG4206	TonB-dependent receptor
INE73_RS16985	COG2814	Major facilitator Superfamily
INE73_RS17005	COG0745	RESPONSE REGULATOR receiver
INE73_RS17005	COG3292	Two component regulator propeller
INE73_RS17005	COG2205	protein histidine kinase activity
INE73_RS17010	COG1621	beta-fructofuranosidase activity
INE73_RS17045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INE73_RS17050	COG3409	Peptidoglycan-binding domain 1 protein
INE73_RS17050	COG0793	Belongs to the peptidase S41A family
INE73_RS17070	COG1053	succinate dehydrogenase
INE73_RS17075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INE73_RS17090	COG4771	TonB-dependent receptor
INE73_RS17125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INE73_RS17125	COG0758	DNA mediated transformation
INE73_RS17135	COG0826	peptidase U32
INE73_RS17145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE73_RS17160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
INE73_RS17165	COG0557	exoribonuclease II activity
INE73_RS17185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INE73_RS17200	COG0012	GTP binding
INE73_RS17205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
INE73_RS17210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INE73_RS17220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE73_RS17230	COG0495	leucyl-tRNA aminoacylation
INE73_RS17235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE73_RS17245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
INE73_RS17265	COG0731	radical SAM domain protein
INE73_RS17265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE73_RS17290	COG0659	secondary active sulfate transmembrane transporter activity
INE73_RS17295	COG1592	Rubrerythrin
INE73_RS17300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
INE73_RS17320	COG0427	acetyl-CoA hydrolase
INE73_RS17330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE73_RS17340	COG3250	beta-galactosidase activity
INE73_RS17425	COG2177	Part of the ABC transporter FtsEX involved in
INE73_RS17440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INE73_RS17445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE73_RS17450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INE73_RS17460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INE73_RS17465	COG1611	Belongs to the LOG family
INE73_RS17480	COG0594	ribonuclease P activity
INE73_RS17485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INE73_RS17500	COG0823	Involved in the tonB-independent uptake of proteins
INE73_RS17500	COG4946	Tricorn protease homolog
INE73_RS17500	COG1506	peptidase
INE73_RS17520	COG3119	arylsulfatase activity
INE73_RS17525	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
INE73_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
INE73_RS17540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INE73_RS17570	COG1121	(ABC) transporter
INE73_RS17580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
INE73_RS17580	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
INE73_RS17595	COG0151	Belongs to the GarS family
INE73_RS17600	COG1506	peptidase
INE73_RS17600	COG0823	Involved in the tonB-independent uptake of proteins
INE73_RS17605	COG0116	Belongs to the methyltransferase superfamily
INE73_RS17610	COG1045	serine acetyltransferase
INE73_RS17615	COG3275	phosphorelay sensor kinase activity
INE73_RS17620	COG3279	Response regulator of the LytR AlgR family
INE73_RS17650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INE73_RS17655	COG1694	Mazg nucleotide pyrophosphohydrolase
INE73_RS17665	COG0322	excinuclease ABC activity
INE73_RS17670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE73_RS17700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INE73_RS17720	COG2715	membrane protein required for spore maturation
INE73_RS17730	COG2255	four-way junction helicase activity
INE73_RS17745	COG3591	Belongs to the peptidase S1B family
INE73_RS17760	COG0513	Belongs to the DEAD box helicase family
INE73_RS17770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE73_RS17785	COG0612	Peptidase, M16
INE73_RS17800	COG1312	Catalyzes the dehydration of D-mannonate
INE73_RS17805	COG1028	Short-chain dehydrogenase reductase Sdr
INE73_RS17815	COG0681	Belongs to the peptidase S26 family
INE73_RS17820	COG0681	Belongs to the peptidase S26 family
INE73_RS17825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INE73_RS17855	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE73_RS17870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE73_RS17875	COG3250	beta-galactosidase activity
INE73_RS17895	COG0215	cysteine-tRNA ligase activity
INE73_RS17900	COG0561	phosphatase activity
INE73_RS17905	COG0745	RESPONSE REGULATOR receiver
INE73_RS17925	COG0745	RESPONSE REGULATOR receiver
INE73_RS17930	COG5002	protein histidine kinase activity
INE73_RS17935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INE73_RS17950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INE73_RS17955	COG0482	sulfurtransferase activity
INE73_RS17965	COG0205	6-phosphofructokinase activity
INE73_RS17975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INE73_RS17980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INE73_RS17985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INE73_RS17990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE73_RS18005	COG1442	glycosyl transferase family 8
INE73_RS18015	COG1215	transferase activity, transferring glycosyl groups
INE73_RS18020	COG1442	glycosyl transferase family 8
INE73_RS18020	COG1216	Glycosyl transferase, family 2
INE73_RS18025	COG1132	(ABC) transporter
INE73_RS18035	COG0328	RNA-DNA hybrid ribonuclease activity
INE73_RS18035	COG3341	Caulimovirus viroplasmin
INE73_RS18045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INE73_RS18055	COG0326	Molecular chaperone. Has ATPase activity
INE73_RS18065	COG1166	arginine decarboxylase activity
INE73_RS18070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INE73_RS18145	COG1454	alcohol dehydrogenase
INE73_RS18150	COG0235	Class ii aldolase
INE73_RS18155	COG1070	Carbohydrate kinase
INE73_RS18160	COG0738	Major facilitator superfamily
INE73_RS18180	COG0779	Required for maturation of 30S ribosomal subunits
INE73_RS18185	COG0195	Participates in both transcription termination and antitermination
INE73_RS18190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INE73_RS18200	COG0719	Fe-S assembly protein
INE73_RS18210	COG0396	ATPase activity
INE73_RS18215	COG0719	Fe-S assembly protein
INE73_RS18220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INE73_RS18225	COG0393	Putative heavy-metal-binding
INE73_RS18240	COG4771	TonB-dependent receptor
INE73_RS18265	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
INE73_RS18275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INE73_RS18310	COG0187	DNA topoisomerase II activity
INE73_RS18315	COG0268	Binds directly to 16S ribosomal RNA
INE73_RS18325	COG1381	Involved in DNA repair and RecF pathway recombination
INE73_RS18330	COG1610	YqeY-like protein
INE73_RS18335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INE73_RS18350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INE73_RS18355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INE73_RS18360	COG0772	Belongs to the SEDS family
INE73_RS18365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INE73_RS18370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE73_RS18375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INE73_RS18395	COG2001	Belongs to the MraZ family
INE73_RS18415	COG4771	TonB-dependent receptor
INE73_RS18440	COG0756	dUTP diphosphatase activity
INE73_RS18455	COG4942	peptidase
INE73_RS18460	COG2205	protein histidine kinase activity
INE73_RS18460	COG3292	Two component regulator propeller
INE73_RS18460	COG0745	RESPONSE REGULATOR receiver
INE73_RS18465	COG3940	Belongs to the glycosyl hydrolase 43 family
INE73_RS18480	COG3250	beta-galactosidase activity
INE73_RS18495	COG3940	Belongs to the glycosyl hydrolase 43 family
INE73_RS18515	COG0383	alpha-mannosidase activity
INE73_RS18515	COG0383	alpha-mannosidase activity
INE73_RS18520	COG4206	TonB-dependent receptor
INE73_RS18520	COG1629	transport
INE73_RS18540	COG3507	Belongs to the glycosyl hydrolase 43 family
INE73_RS18560	COG3537	Alpha-1,2-mannosidase
INE73_RS18570	COG2017	converts alpha-aldose to the beta-anomer
INE73_RS18640	COG3408	Glycogen debranching enzyme
INE73_RS18645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INE73_RS18650	COG1022	Amp-dependent synthetase and ligase
INE73_RS18665	COG2954	triphosphatase activity
INE73_RS18685	COG3250	beta-galactosidase activity
INE73_RS18690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE73_RS18700	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE73_RS18715	COG1629	transport
INE73_RS18715	COG4206	TonB-dependent receptor
INE73_RS18720	COG3292	Two component regulator propeller
INE73_RS18720	COG2205	protein histidine kinase activity
INE73_RS18720	COG0745	RESPONSE REGULATOR receiver
INE73_RS18725	COG3292	Two component regulator propeller
INE73_RS18725	COG2205	protein histidine kinase activity
INE73_RS18725	COG0745	RESPONSE REGULATOR receiver
INE73_RS18750	COG4771	TonB-dependent receptor
INE73_RS18785	COG4771	TonB-dependent receptor
INE73_RS18810	COG0423	glycine-tRNA ligase activity
INE73_RS18815	COG0545	Peptidyl-prolyl cis-trans isomerase
INE73_RS18845	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
INE73_RS18855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE73_RS18875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
INE73_RS18895	COG3876	Protein conserved in bacteria
INE73_RS18930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE73_RS18935	COG3876	Protein conserved in bacteria
INE73_RS18940	COG0702	epimerase
INE73_RS18945	COG4206	TonB-dependent receptor
INE73_RS18945	COG1629	transport
INE73_RS18955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INE73_RS18960	COG0475	glutathione-regulated potassium exporter activity
INE73_RS18960	COG0589	response to stress
INE73_RS18965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INE73_RS18970	COG1136	(ABC) transporter
INE73_RS18980	COG0733	neurotransmitter:sodium symporter activity
INE73_RS18990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INE73_RS19000	COG0076	glutamate decarboxylase activity
INE73_RS19005	COG2066	Belongs to the glutaminase family
INE73_RS19010	COG0784	Response regulator, receiver
INE73_RS19010	COG2198	Histidine kinase
INE73_RS19010	COG5002	protein histidine kinase activity
INE73_RS19015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INE73_RS19020	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
INE73_RS19075	COG1346	cytolysis
INE73_RS19100	COG0280	phosphate acetyltransferase
INE73_RS19105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INE73_RS19110	COG1785	Belongs to the alkaline phosphatase family
INE73_RS19115	COG2151	metal-sulfur cluster biosynthetic enzyme
INE73_RS19120	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE73_RS19125	COG2003	Belongs to the UPF0758 family
INE73_RS19130	COG1216	Glycosyl transferase, family 2
INE73_RS19130	COG0463	Glycosyl transferase, family 2
INE73_RS19140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
INE73_RS19145	COG0515	serine threonine protein kinase
INE73_RS19145	COG2815	serine threonine protein kinase
INE73_RS19150	COG0564	pseudouridine synthase activity
INE73_RS19190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INE73_RS19195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
INE73_RS19205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INE73_RS19225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INE73_RS19235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE73_RS19235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE73_RS19240	COG2890	protein-(glutamine-N5) methyltransferase activity
INE73_RS19245	COG2137	regulation of response to DNA damage stimulus
INE73_RS19250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INE73_RS19285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
INE73_RS19290	COG1396	sequence-specific DNA binding
INE73_RS19290	COG1917	Cupin 2, conserved barrel domain protein
INE73_RS19295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INE73_RS19300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INE73_RS19305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INE73_RS19310	COG0137	argininosuccinate synthase activity
INE73_RS19320	COG1438	arginine binding
INE73_RS19335	COG4999	Histidine kinase
INE73_RS19335	COG3850	Histidine kinase
INE73_RS19335	COG3437	response regulator, receiver
INE73_RS19335	COG2205	protein histidine kinase activity
INE73_RS19340	COG0531	amino acid
INE73_RS19350	COG0039	L-malate dehydrogenase activity
INE73_RS19355	COG2996	Protein conserved in bacteria
INE73_RS19375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INE73_RS19380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE73_RS19405	COG1629	transport
INE73_RS19430	COG1136	(ABC) transporter
INE73_RS19430	COG0577	efflux transmembrane transporter activity
INE73_RS19435	COG1136	(ABC) transporter
INE73_RS19435	COG0577	efflux transmembrane transporter activity
INE73_RS19440	COG1136	(ABC) transporter
INE73_RS19445	COG1940	carbohydrate kinase activity
INE73_RS19450	COG0335	large ribosomal subunit rRNA binding
INE73_RS19455	COG0737	Belongs to the 5'-nucleotidase family
INE73_RS19460	COG0737	Belongs to the 5'-nucleotidase family
INE73_RS19465	COG1472	Belongs to the glycosyl hydrolase 3 family
INE73_RS19470	COG1472	Belongs to the glycosyl hydrolase 3 family
INE73_RS19475	COG4206	TonB-dependent receptor
INE73_RS19475	COG1629	transport
INE73_RS19485	COG3119	arylsulfatase activity
INE73_RS19510	COG0446	pyridine nucleotide-disulphide oxidoreductase
INE73_RS19525	COG2204	response regulator
INE73_RS19535	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
INE73_RS19555	COG2205	protein histidine kinase activity
INE73_RS19560	COG5002	protein histidine kinase activity
INE73_RS19575	COG4771	TonB-dependent receptor
INE73_RS19620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE73_RS19620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE73_RS19625	COG0436	Aminotransferase
INE73_RS19630	COG3250	beta-galactosidase activity
INE73_RS19640	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
INE73_RS19645	COG0826	peptidase U32
INE73_RS19655	COG4771	TonB-dependent receptor
INE73_RS19660	COG2197	response regulator
INE73_RS19665	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
INE73_RS19675	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INE73_RS19680	COG0252	asparaginase activity
INE73_RS19685	COG0527	aspartate kinase activity
INE73_RS19685	COG0460	homoserine dehydrogenase
INE73_RS19690	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
INE73_RS19695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INE73_RS19755	COG4771	TonB-dependent receptor
INE73_RS19775	COG3250	beta-galactosidase activity
INE73_RS19780	COG3250	beta-galactosidase activity
INE73_RS19790	COG3250	beta-galactosidase activity
INE73_RS19800	COG4771	TonB-dependent receptor
INE73_RS19845	COG4771	TonB-dependent receptor
INE73_RS19910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE73_RS19910	COG0551	DNA topoisomerase type I activity
INE73_RS19965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INE73_RS19970	COG0798	PFAM Bile acid sodium symporter
INE73_RS19980	COG0534	Mate efflux family protein
INE73_RS19985	COG0189	ligase activity
INE73_RS19985	COG2918	glutathione biosynthetic process
INE73_RS19990	COG1045	serine acetyltransferase
INE73_RS20000	COG0784	Response regulator, receiver
INE73_RS20000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE73_RS20000	COG2198	Histidine kinase
INE73_RS20000	COG2205	protein histidine kinase activity
INE73_RS20005	COG2204	response regulator
INE73_RS20230	COG0628	permease
INE73_RS20245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE73_RS20260	COG2095	MarC family integral membrane protein
INE73_RS20270	COG1629	transport
INE73_RS20280	COG1629	transport
INE73_RS20285	COG1629	transport
INE73_RS20295	COG4771	TonB-dependent receptor
INE73_RS20300	COG0702	epimerase
INE73_RS20305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INE73_RS20320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INE73_RS20320	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INE73_RS20335	COG0531	amino acid
INE73_RS20345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE73_RS20350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE73_RS20355	COG1162	GTPase activity
INE73_RS20360	COG0233	cytoplasmic translational termination
INE73_RS20370	COG0528	UMP kinase activity
INE73_RS20375	COG0534	Mate efflux family protein
INE73_RS20405	COG0792	nuclease activity
INE73_RS20425	COG1183	phosphatidylcholine synthase activity
INE73_RS20430	COG0688	phosphatidylethanolamine metabolic process
INE73_RS20440	COG3118	belongs to the thioredoxin family
INE73_RS20475	COG0714	Associated with various cellular activities
INE73_RS20490	COG0802	atpase or kinase
INE73_RS20495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INE73_RS20505	COG2234	aminopeptidase activity
INE73_RS20525	COG1629	transport
INE73_RS20545	COG3250	beta-galactosidase activity
INE73_RS20550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INE73_RS20560	COG0784	Response regulator, receiver
INE73_RS20560	COG2205	protein histidine kinase activity
INE73_RS20585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INE73_RS20600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INE73_RS20605	COG0742	ribosomal rna small subunit methyltransferase
INE73_RS20630	COG4771	TonB-dependent receptor
INE73_RS20640	COG3537	Alpha-1,2-mannosidase
INE73_RS20655	COG3537	Alpha-1,2-mannosidase
INE73_RS20660	COG2814	Major facilitator Superfamily
INE73_RS20675	COG0739	heme binding
INE73_RS20685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INE73_RS20690	COG3942	CHAP domain
INE73_RS20690	COG1388	LysM domain
INE73_RS20700	COG1475	DNA binding
INE73_RS20705	COG1192	Involved in chromosome partitioning
INE73_RS20710	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
INE73_RS20715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE73_RS20730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INE73_RS20735	COG0799	negative regulation of ribosome biogenesis
INE73_RS20750	COG2239	Acts as a magnesium transporter
INE73_RS20755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INE73_RS20765	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE73_RS20835	COG0668	transmembrane transport
INE73_RS20840	COG0662	Cupin 2, conserved barrel domain protein
INE73_RS20840	COG2207	Transcriptional regulator
INE73_RS20915	COG1215	transferase activity, transferring glycosyl groups
INE73_RS20925	COG1442	glycosyl transferase family 8
INE73_RS20925	COG1216	Glycosyl transferase, family 2
INE73_RS20930	COG1086	Polysaccharide biosynthesis protein
INE73_RS20935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE73_RS20940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
INE73_RS20980	COG1215	transferase activity, transferring glycosyl groups
INE73_RS20985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INE73_RS20990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE73_RS21000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE73_RS21020	COG0667	Aldo Keto reductase
INE73_RS21025	COG1472	Belongs to the glycosyl hydrolase 3 family
INE73_RS21030	COG4771	TonB-dependent receptor
INE73_RS21035	COG0702	epimerase
INE73_RS21075	COG5012	cobalamin binding
INE73_RS21090	COG4124	Belongs to the glycosyl hydrolase 26 family
INE73_RS21095	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE73_RS21100	COG2211	Major facilitator Superfamily
INE73_RS21105	COG2942	2-epimerase
INE73_RS21135	COG1404	Belongs to the peptidase S8 family
INE73_RS21135	COG4412	M6 family metalloprotease domain protein
INE73_RS21140	COG5002	protein histidine kinase activity
INE73_RS21140	COG2205	protein histidine kinase activity
INE73_RS21140	COG0784	Response regulator, receiver
INE73_RS21150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE73_RS21155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INE73_RS21160	COG0713	ATP synthesis coupled electron transport
INE73_RS21165	COG0839	Belongs to the complex I subunit 6 family
INE73_RS21175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INE73_RS21180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE73_RS21180	COG0649	NAD binding
INE73_RS21185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE73_RS21190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE73_RS21200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE73_RS21205	COG0569	domain protein
INE73_RS21210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INE73_RS21215	COG1073	alpha beta
INE73_RS21230	COG3119	arylsulfatase activity
INE73_RS21245	COG3119	arylsulfatase activity
INE73_RS21255	COG4771	TonB-dependent receptor
INE73_RS21260	COG2205	protein histidine kinase activity
INE73_RS21260	COG3292	Two component regulator propeller
INE73_RS21260	COG0745	RESPONSE REGULATOR receiver
INE73_RS21265	COG2271	Major facilitator Superfamily
INE73_RS21290	COG0805	protein transport
INE73_RS21295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INE73_RS21300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INE73_RS21330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE73_RS21340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE73_RS21345	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
INE73_RS21345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INE73_RS21350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE73_RS21355	COG1078	dGTPase activity
INE73_RS21360	COG0284	orotidine-5'-phosphate decarboxylase activity
INE73_RS21365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INE73_RS21370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INE73_RS21375	COG1704	LemA family
INE73_RS21390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INE73_RS21395	COG2226	methyltransferase
INE73_RS21400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INE73_RS21405	COG1702	phosphate starvation-inducible protein PhoH
INE73_RS21415	COG2268	Band 7 protein
INE73_RS21425	COG5434	Belongs to the glycosyl hydrolase 28 family
INE73_RS21455	COG3250	beta-galactosidase activity
INE73_RS21460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE73_RS21485	COG0457	Tetratricopeptide repeat
INE73_RS21490	COG2814	Major facilitator Superfamily
INE73_RS21520	COG1629	transport
INE73_RS21520	COG4206	TonB-dependent receptor
INE73_RS21530	COG4771	TonB-dependent receptor
INE73_RS21545	COG1629	transport
INE73_RS21545	COG4206	TonB-dependent receptor