locus-tag	class	description
EE52_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EE52_RS00020	COG1640	4-alpha-glucanotransferase
EE52_RS00030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EE52_RS00035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EE52_RS00060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EE52_RS00065	COG1022	Amp-dependent synthetase and ligase
EE52_RS00080	COG0359	binds to the 23S rRNA
EE52_RS00085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EE52_RS00090	COG0360	Binds together with S18 to 16S ribosomal RNA
EE52_RS00110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EE52_RS00140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EE52_RS00160	COG4771	TonB-dependent receptor
EE52_RS00175	COG2431	L-lysine efflux transmembrane transporter activity
EE52_RS00185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE52_RS00190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS00195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EE52_RS00205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EE52_RS00210	COG1215	transferase activity, transferring glycosyl groups
EE52_RS00235	COG0110	maltose O-acetyltransferase activity
EE52_RS00250	COG0562	UDP-galactopyranose mutase
EE52_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EE52_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
EE52_RS00320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EE52_RS00325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EE52_RS00375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EE52_RS00380	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EE52_RS00385	COG0386	Belongs to the glutathione peroxidase family
EE52_RS00405	COG3275	phosphorelay sensor kinase activity
EE52_RS00410	COG3279	Response regulator of the LytR AlgR family
EE52_RS00420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EE52_RS00430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EE52_RS00445	COG3250	beta-galactosidase activity
EE52_RS00450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EE52_RS00460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EE52_RS00465	COG0658	competence protein
EE52_RS00470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EE52_RS00475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EE52_RS00485	COG0009	L-threonylcarbamoyladenylate synthase
EE52_RS00515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE52_RS00520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS00530	COG1216	Glycosyl transferase, family 2
EE52_RS00540	COG1215	transferase activity, transferring glycosyl groups
EE52_RS00550	COG0110	maltose O-acetyltransferase activity
EE52_RS00580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EE52_RS00585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EE52_RS00625	COG0519	Catalyzes the synthesis of GMP from XMP
EE52_RS00635	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EE52_RS00635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EE52_RS00640	COG0514	ATP-dependent DNA helicase (RecQ)
EE52_RS00655	COG0436	Aminotransferase
EE52_RS00660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EE52_RS00690	COG0358	DNA primase activity
EE52_RS00695	COG3119	arylsulfatase activity
EE52_RS00700	COG0702	epimerase
EE52_RS00705	COG4206	TonB-dependent receptor
EE52_RS00705	COG1629	transport
EE52_RS00720	COG0302	gtp cyclohydrolase
EE52_RS00730	COG0149	triose-phosphate isomerase activity
EE52_RS00745	COG0739	heme binding
EE52_RS00750	COG0105	UTP biosynthetic process
EE52_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EE52_RS00760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EE52_RS00780	COG0811	peptide transport
EE52_RS00790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EE52_RS00840	COG1629	transport
EE52_RS00870	COG0823	Involved in the tonB-independent uptake of proteins
EE52_RS00870	COG1506	peptidase
EE52_RS00870	COG4946	Tricorn protease homolog
EE52_RS00875	COG0039	L-malate dehydrogenase activity
EE52_RS00895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS00910	COG4948	Mandelate Racemase Muconate Lactonizing
EE52_RS00935	COG3118	belongs to the thioredoxin family
EE52_RS00940	COG0489	protein tyrosine kinase activity
EE52_RS00955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EE52_RS00965	COG1570	exodeoxyribonuclease VII activity
EE52_RS00975	COG0482	sulfurtransferase activity
EE52_RS01000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EE52_RS01005	COG0179	Fumarylacetoacetate (FAA) hydrolase
EE52_RS01010	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EE52_RS01020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EE52_RS01025	COG0052	Belongs to the universal ribosomal protein uS2 family
EE52_RS01030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EE52_RS01035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EE52_RS01050	COG0017	Asparaginyl-tRNA synthetase
EE52_RS01055	COG1187	pseudouridine synthase activity
EE52_RS01085	COG0110	maltose O-acetyltransferase activity
EE52_RS01090	COG3022	response to hydroperoxide
EE52_RS01095	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS01155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EE52_RS01195	COG1216	Glycosyl transferase, family 2
EE52_RS01230	COG0438	transferase activity, transferring glycosyl groups
EE52_RS01305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EE52_RS01320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EE52_RS01335	COG0517	IMP dehydrogenase activity
EE52_RS01335	COG0516	GMP reductase activity
EE52_RS01340	COG0514	ATP-dependent DNA helicase (RecQ)
EE52_RS01345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EE52_RS01355	COG0544	peptidyl-prolyl cis-trans isomerase activity
EE52_RS01360	COG0724	RNA recognition motif
EE52_RS01370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EE52_RS01375	COG1127	ABC transporter
EE52_RS01380	COG0745	RESPONSE REGULATOR receiver
EE52_RS01385	COG1160	GTP binding
EE52_RS01390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EE52_RS01395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EE52_RS01445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EE52_RS01450	COG0470	DNA polymerase III
EE52_RS01455	COG1774	PSP1 C-terminal conserved region
EE52_RS01465	COG0772	Belongs to the SEDS family
EE52_RS01480	COG1792	Involved in formation and maintenance of cell shape
EE52_RS01490	COG0138	bifunctional purine biosynthesis protein purh
EE52_RS01495	COG3590	peptidase
EE52_RS01500	COG0488	(ABC) transporter
EE52_RS01525	COG0784	Response regulator, receiver
EE52_RS01525	COG2205	protein histidine kinase activity
EE52_RS01530	COG0534	Mate efflux family protein
EE52_RS01535	COG0612	Peptidase, M16
EE52_RS01540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EE52_RS01555	COG0564	pseudouridine synthase activity
EE52_RS01595	COG1131	(ABC) transporter
EE52_RS01685	COG1696	Membrane protein involved in D-alanine export
EE52_RS01720	COG1309	transcriptional regulator
EE52_RS01725	COG2986	histidine ammonia-lyase
EE52_RS01735	COG1228	amidohydrolase
EE52_RS01745	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EE52_RS01755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EE52_RS01770	COG0203	ribosomal protein L17
EE52_RS01775	COG0202	RNA polymerase activity
EE52_RS01780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EE52_RS01785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EE52_RS01790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EE52_RS01795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EE52_RS01800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EE52_RS01815	COG0200	Binds to the 23S rRNA
EE52_RS01820	COG1841	ribosomal large subunit assembly
EE52_RS01825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EE52_RS01830	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EE52_RS01835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EE52_RS01840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EE52_RS01845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EE52_RS01850	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EE52_RS01855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EE52_RS01860	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EE52_RS01865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EE52_RS01870	COG0255	Belongs to the universal ribosomal protein uL29 family
EE52_RS01875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EE52_RS01880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EE52_RS01885	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EE52_RS01890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EE52_RS01895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EE52_RS01900	COG0089	rRNA binding
EE52_RS01905	COG0088	Forms part of the polypeptide exit tunnel
EE52_RS01910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EE52_RS01915	COG0051	transcription antitermination factor activity, RNA binding
EE52_RS01920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EE52_RS01925	COG0049	tRNA binding
EE52_RS01930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EE52_RS01960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EE52_RS01965	COG0085	RNA polymerase activity
EE52_RS01970	COG0222	ribosome binding
EE52_RS01975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EE52_RS01980	COG0081	regulation of translation
EE52_RS01985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EE52_RS02030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EE52_RS02035	COG4974	Belongs to the 'phage' integrase family
EE52_RS02040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EE52_RS02045	COG0006	proline dipeptidase activity
EE52_RS02050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EE52_RS02060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EE52_RS02065	COG1480	7TM receptor with intracellular HD hydrolase
EE52_RS02070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EE52_RS02080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EE52_RS02095	COG1027	Aspartate ammonia-lyase
EE52_RS02100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EE52_RS02105	COG0252	asparaginase activity
EE52_RS02175	COG2096	Adenosyltransferase
EE52_RS02215	COG1629	transport
EE52_RS02245	COG0657	acetylesterase activity
EE52_RS02245	COG2755	lipolytic protein G-D-S-L family
EE52_RS02295	COG3279	Response regulator of the LytR AlgR family
EE52_RS02310	COG4771	TonB-dependent receptor
EE52_RS02330	COG2197	response regulator
EE52_RS02335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EE52_RS02340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EE52_RS02380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EE52_RS02390	COG1185	polyribonucleotide nucleotidyltransferase activity
EE52_RS02405	COG4771	TonB-dependent receptor
EE52_RS02450	COG3426	butyrate kinase activity
EE52_RS02455	COG0280	phosphate acetyltransferase
EE52_RS02465	COG1619	proteins homologs of microcin C7 resistance protein MccF
EE52_RS02470	COG2234	aminopeptidase activity
EE52_RS02475	COG2166	iron-sulfur cluster assembly
EE52_RS02480	COG3655	Transcriptional regulator
EE52_RS02490	COG1266	CAAX protease self-immunity
EE52_RS02495	COG0196	riboflavin kinase activity
EE52_RS02500	COG1011	Hydrolase
EE52_RS02505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EE52_RS02510	COG0784	Response regulator, receiver
EE52_RS02510	COG5002	protein histidine kinase activity
EE52_RS02515	COG1773	rubredoxin
EE52_RS02520	COG1283	sodium-dependent phosphate transmembrane transporter activity
EE52_RS02530	COG2205	protein histidine kinase activity
EE52_RS02555	COG0006	proline dipeptidase activity
EE52_RS02570	COG0509	glycine decarboxylation via glycine cleavage system
EE52_RS02575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EE52_RS02605	COG0702	epimerase
EE52_RS02610	COG4771	TonB-dependent receptor
EE52_RS02625	COG0793	Belongs to the peptidase S41A family
EE52_RS02630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EE52_RS02665	COG4771	TonB-dependent receptor
EE52_RS02670	COG3292	Two component regulator propeller
EE52_RS02670	COG2205	protein histidine kinase activity
EE52_RS02670	COG0745	RESPONSE REGULATOR receiver
EE52_RS02675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EE52_RS02680	COG1882	Formate acetyltransferase
EE52_RS02685	COG0477	Major facilitator Superfamily
EE52_RS02685	COG2814	Major facilitator Superfamily
EE52_RS02710	COG0483	inositol monophosphate 1-phosphatase activity
EE52_RS02720	COG3345	alpha-galactosidase
EE52_RS02745	COG3475	LICD family
EE52_RS02750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EE52_RS02780	COG1442	glycosyl transferase family 8
EE52_RS02830	COG2816	NAD+ diphosphatase activity
EE52_RS02885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EE52_RS03135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EE52_RS03190	COG3723	Recombinational DNA repair protein, rece pathway
EE52_RS03195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EE52_RS03255	COG0674	pyruvate-flavodoxin oxidoreductase activity
EE52_RS03255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EE52_RS03260	COG1013	pyruvate-flavodoxin oxidoreductase activity
EE52_RS03270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EE52_RS03275	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EE52_RS03280	COG4206	TonB-dependent receptor
EE52_RS03280	COG1629	transport
EE52_RS03295	COG1629	transport
EE52_RS03330	COG1629	transport
EE52_RS03345	COG1217	gtp-binding protein TYPA
EE52_RS03350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EE52_RS03360	COG0318	PFAM AMP-dependent synthetase and ligase
EE52_RS03365	COG0784	Response regulator, receiver
EE52_RS03365	COG2205	protein histidine kinase activity
EE52_RS03365	COG5002	protein histidine kinase activity
EE52_RS03385	COG3119	arylsulfatase activity
EE52_RS03395	COG1629	transport
EE52_RS03395	COG4206	TonB-dependent receptor
EE52_RS03415	COG4591	ABC-type transport system involved in lipoprotein release permease component
EE52_RS03420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EE52_RS03435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EE52_RS03440	COG4974	Belongs to the 'phage' integrase family
EE52_RS03455	COG0606	chelatase, subunit chli
EE52_RS03560	COG0438	transferase activity, transferring glycosyl groups
EE52_RS03585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EE52_RS03590	COG0438	transferase activity, transferring glycosyl groups
EE52_RS03600	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EE52_RS03605	COG0545	Peptidyl-prolyl cis-trans isomerase
EE52_RS03610	COG0545	Peptidyl-prolyl cis-trans isomerase
EE52_RS03615	COG1522	sequence-specific DNA binding
EE52_RS03635	COG3275	phosphorelay sensor kinase activity
EE52_RS03650	COG1566	PFAM secretion protein HlyD family protein
EE52_RS03715	COG1629	transport
EE52_RS03715	COG4206	TonB-dependent receptor
EE52_RS03725	COG2814	Major facilitator Superfamily
EE52_RS03750	COG0745	RESPONSE REGULATOR receiver
EE52_RS03750	COG3292	Two component regulator propeller
EE52_RS03750	COG2205	protein histidine kinase activity
EE52_RS03755	COG1621	beta-fructofuranosidase activity
EE52_RS03800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EE52_RS03805	COG0793	Belongs to the peptidase S41A family
EE52_RS03805	COG3409	Peptidoglycan-binding domain 1 protein
EE52_RS03840	COG1053	succinate dehydrogenase
EE52_RS03845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EE52_RS03860	COG4771	TonB-dependent receptor
EE52_RS03885	COG0758	DNA mediated transformation
EE52_RS03885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EE52_RS03895	COG0826	peptidase U32
EE52_RS03905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EE52_RS03920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EE52_RS03925	COG0557	exoribonuclease II activity
EE52_RS03950	COG1595	DNA-templated transcription, initiation
EE52_RS03970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EE52_RS03985	COG0012	GTP binding
EE52_RS03990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EE52_RS03995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EE52_RS04005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EE52_RS04015	COG0495	leucyl-tRNA aminoacylation
EE52_RS04020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EE52_RS04040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EE52_RS04060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EE52_RS04060	COG0731	radical SAM domain protein
EE52_RS04085	COG0659	secondary active sulfate transmembrane transporter activity
EE52_RS04090	COG1592	Rubrerythrin
EE52_RS04095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EE52_RS04115	COG0427	acetyl-CoA hydrolase
EE52_RS04125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EE52_RS04135	COG3250	beta-galactosidase activity
EE52_RS04220	COG2177	Part of the ABC transporter FtsEX involved in
EE52_RS04230	COG1968	undecaprenyl-diphosphatase activity
EE52_RS04235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EE52_RS04240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EE52_RS04245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EE52_RS04255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EE52_RS04260	COG1611	Belongs to the LOG family
EE52_RS04275	COG0594	ribonuclease P activity
EE52_RS04280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EE52_RS04295	COG0823	Involved in the tonB-independent uptake of proteins
EE52_RS04295	COG4946	Tricorn protease homolog
EE52_RS04295	COG1506	peptidase
EE52_RS04305	COG3119	arylsulfatase activity
EE52_RS04310	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EE52_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
EE52_RS04320	COG4677	pectinesterase activity
EE52_RS04325	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EE52_RS04345	COG1121	(ABC) transporter
EE52_RS04355	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EE52_RS04355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EE52_RS04375	COG0823	Involved in the tonB-independent uptake of proteins
EE52_RS04375	COG1506	peptidase
EE52_RS04380	COG0116	Belongs to the methyltransferase superfamily
EE52_RS04380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EE52_RS04385	COG1045	serine acetyltransferase
EE52_RS04390	COG3275	phosphorelay sensor kinase activity
EE52_RS04395	COG3279	Response regulator of the LytR AlgR family
EE52_RS04405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EE52_RS04405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EE52_RS04425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EE52_RS04430	COG1694	Mazg nucleotide pyrophosphohydrolase
EE52_RS04440	COG0322	excinuclease ABC activity
EE52_RS04445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EE52_RS04480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EE52_RS04505	COG2715	membrane protein required for spore maturation
EE52_RS04515	COG2255	four-way junction helicase activity
EE52_RS04530	COG3591	Belongs to the peptidase S1B family
EE52_RS04540	COG0513	Belongs to the DEAD box helicase family
EE52_RS04550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EE52_RS04565	COG0612	Peptidase, M16
EE52_RS04585	COG1312	Catalyzes the dehydration of D-mannonate
EE52_RS04590	COG1028	Short-chain dehydrogenase reductase Sdr
EE52_RS04600	COG0681	Belongs to the peptidase S26 family
EE52_RS04610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EE52_RS04640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EE52_RS04655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS04660	COG3250	beta-galactosidase activity
EE52_RS04680	COG0215	cysteine-tRNA ligase activity
EE52_RS04690	COG0561	phosphatase activity
EE52_RS04695	COG0745	RESPONSE REGULATOR receiver
EE52_RS04765	COG0205	6-phosphofructokinase activity
EE52_RS04775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EE52_RS04780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EE52_RS04785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EE52_RS04790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EE52_RS04800	COG1216	Glycosyl transferase, family 2
EE52_RS04820	COG1442	glycosyl transferase family 8
EE52_RS04825	COG1215	transferase activity, transferring glycosyl groups
EE52_RS04830	COG0562	UDP-galactopyranose mutase
EE52_RS04840	COG1132	(ABC) transporter
EE52_RS04845	COG0328	RNA-DNA hybrid ribonuclease activity
EE52_RS04845	COG3341	Caulimovirus viroplasmin
EE52_RS04855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EE52_RS04865	COG0326	Molecular chaperone. Has ATPase activity
EE52_RS04875	COG1166	arginine decarboxylase activity
EE52_RS04880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EE52_RS04885	COG1595	DNA-templated transcription, initiation
EE52_RS04930	COG1454	alcohol dehydrogenase
EE52_RS04935	COG0235	Class ii aldolase
EE52_RS04940	COG1070	Carbohydrate kinase
EE52_RS04945	COG0738	Major facilitator superfamily
EE52_RS04965	COG0779	Required for maturation of 30S ribosomal subunits
EE52_RS04970	COG0195	Participates in both transcription termination and antitermination
EE52_RS04975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EE52_RS04985	COG0719	Fe-S assembly protein
EE52_RS04995	COG0396	ATPase activity
EE52_RS05000	COG0719	Fe-S assembly protein
EE52_RS05005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EE52_RS05010	COG0393	Putative heavy-metal-binding
EE52_RS05015	COG3345	alpha-galactosidase
EE52_RS05025	COG4771	TonB-dependent receptor
EE52_RS05050	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EE52_RS05055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EE52_RS05080	COG0187	DNA topoisomerase II activity
EE52_RS05085	COG0268	Binds directly to 16S ribosomal RNA
EE52_RS05095	COG1381	Involved in DNA repair and RecF pathway recombination
EE52_RS05100	COG1610	YqeY-like protein
EE52_RS05105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EE52_RS05120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EE52_RS05125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EE52_RS05130	COG0772	Belongs to the SEDS family
EE52_RS05135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EE52_RS05140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE52_RS05145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EE52_RS05160	COG0275	rRNA processing
EE52_RS05165	COG2001	Belongs to the MraZ family
EE52_RS05185	COG4771	TonB-dependent receptor
EE52_RS05215	COG0756	dUTP diphosphatase activity
EE52_RS05230	COG4942	peptidase
EE52_RS05235	COG2205	protein histidine kinase activity
EE52_RS05235	COG0745	RESPONSE REGULATOR receiver
EE52_RS05235	COG3292	Two component regulator propeller
EE52_RS05240	COG3940	Belongs to the glycosyl hydrolase 43 family
EE52_RS05290	COG0383	alpha-mannosidase activity
EE52_RS05290	COG0383	alpha-mannosidase activity
EE52_RS05295	COG1629	transport
EE52_RS05295	COG4206	TonB-dependent receptor
EE52_RS05315	COG3507	Belongs to the glycosyl hydrolase 43 family
EE52_RS05335	COG3537	Alpha-1,2-mannosidase
EE52_RS05345	COG2017	converts alpha-aldose to the beta-anomer
EE52_RS05390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EE52_RS05395	COG1022	Amp-dependent synthetase and ligase
EE52_RS05410	COG2954	triphosphatase activity
EE52_RS05430	COG3250	beta-galactosidase activity
EE52_RS05435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS05440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EE52_RS05445	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EE52_RS05465	COG4206	TonB-dependent receptor
EE52_RS05465	COG1629	transport
EE52_RS05470	COG2205	protein histidine kinase activity
EE52_RS05470	COG0745	RESPONSE REGULATOR receiver
EE52_RS05470	COG3292	Two component regulator propeller
EE52_RS05475	COG0745	RESPONSE REGULATOR receiver
EE52_RS05475	COG2205	protein histidine kinase activity
EE52_RS05475	COG3292	Two component regulator propeller
EE52_RS05500	COG4771	TonB-dependent receptor
EE52_RS05540	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
EE52_RS05590	COG4771	TonB-dependent receptor
EE52_RS05615	COG0423	glycine-tRNA ligase activity
EE52_RS05635	COG3005	denitrification pathway
EE52_RS05640	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EE52_RS05650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EE52_RS05670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EE52_RS05690	COG3876	Protein conserved in bacteria
EE52_RS05710	COG1216	Glycosyl transferase, family 2
EE52_RS05710	COG0463	Glycosyl transferase, family 2
EE52_RS05725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EE52_RS05730	COG3876	Protein conserved in bacteria
EE52_RS05740	COG4206	TonB-dependent receptor
EE52_RS05740	COG1629	transport
EE52_RS05750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EE52_RS05755	COG0475	glutathione-regulated potassium exporter activity
EE52_RS05755	COG0589	response to stress
EE52_RS05760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EE52_RS05795	COG0733	neurotransmitter:sodium symporter activity
EE52_RS05805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EE52_RS05820	COG0076	glutamate decarboxylase activity
EE52_RS05825	COG2066	Belongs to the glutaminase family
EE52_RS05830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EE52_RS05830	COG2205	protein histidine kinase activity
EE52_RS05835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EE52_RS05840	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EE52_RS05955	COG1346	cytolysis
EE52_RS05980	COG0280	phosphate acetyltransferase
EE52_RS05985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EE52_RS05990	COG1785	Belongs to the alkaline phosphatase family
EE52_RS06000	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EE52_RS06005	COG2003	Belongs to the UPF0758 family
EE52_RS06010	COG0463	Glycosyl transferase, family 2
EE52_RS06010	COG1216	Glycosyl transferase, family 2
EE52_RS06015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EE52_RS06020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EE52_RS06025	COG0515	serine threonine protein kinase
EE52_RS06025	COG2815	serine threonine protein kinase
EE52_RS06030	COG0564	pseudouridine synthase activity
EE52_RS06075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EE52_RS06080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EE52_RS06090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EE52_RS06110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EE52_RS06120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EE52_RS06120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EE52_RS06125	COG2890	protein-(glutamine-N5) methyltransferase activity
EE52_RS06130	COG2137	regulation of response to DNA damage stimulus
EE52_RS06135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EE52_RS06160	COG1929	Belongs to the glycerate kinase type-1 family
EE52_RS06170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EE52_RS06175	COG1396	sequence-specific DNA binding
EE52_RS06175	COG1917	Cupin 2, conserved barrel domain protein
EE52_RS06180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EE52_RS06185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EE52_RS06190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EE52_RS06195	COG0137	argininosuccinate synthase activity
EE52_RS06230	COG4999	Histidine kinase
EE52_RS06230	COG3850	Histidine kinase
EE52_RS06230	COG3437	response regulator, receiver
EE52_RS06230	COG2205	protein histidine kinase activity
EE52_RS06235	COG0531	amino acid
EE52_RS06245	COG0039	L-malate dehydrogenase activity
EE52_RS06250	COG2996	Protein conserved in bacteria
EE52_RS06280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EE52_RS06285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EE52_RS06295	COG1472	Belongs to the glycosyl hydrolase 3 family
EE52_RS06310	COG0702	epimerase
EE52_RS06315	COG4771	TonB-dependent receptor
EE52_RS06340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS06345	COG1136	(ABC) transporter
EE52_RS06345	COG0577	efflux transmembrane transporter activity
EE52_RS06350	COG0577	efflux transmembrane transporter activity
EE52_RS06350	COG1136	(ABC) transporter
EE52_RS06355	COG1136	(ABC) transporter
EE52_RS06360	COG1940	carbohydrate kinase activity
EE52_RS06365	COG0335	large ribosomal subunit rRNA binding
EE52_RS06370	COG0737	Belongs to the 5'-nucleotidase family
EE52_RS06375	COG0737	Belongs to the 5'-nucleotidase family
EE52_RS06380	COG1472	Belongs to the glycosyl hydrolase 3 family
EE52_RS06385	COG1472	Belongs to the glycosyl hydrolase 3 family
EE52_RS06390	COG1629	transport
EE52_RS06390	COG4206	TonB-dependent receptor
EE52_RS06400	COG3119	arylsulfatase activity
EE52_RS06425	COG0446	pyridine nucleotide-disulphide oxidoreductase
EE52_RS06435	COG2204	response regulator
EE52_RS06445	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EE52_RS06465	COG2205	protein histidine kinase activity
EE52_RS06470	COG5002	protein histidine kinase activity
EE52_RS06485	COG4771	TonB-dependent receptor
EE52_RS06525	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EE52_RS06525	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EE52_RS06530	COG0436	Aminotransferase
EE52_RS06545	COG0826	peptidase U32
EE52_RS06555	COG4771	TonB-dependent receptor
EE52_RS06565	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EE52_RS06575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EE52_RS06585	COG0489	protein tyrosine kinase activity
EE52_RS06585	COG3206	protein involved in exopolysaccharide biosynthesis
EE52_RS06595	COG0460	homoserine dehydrogenase
EE52_RS06595	COG0527	aspartate kinase activity
EE52_RS06600	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
EE52_RS06655	COG4771	TonB-dependent receptor
EE52_RS06660	COG0702	epimerase
EE52_RS06670	COG3250	beta-galactosidase activity
EE52_RS06680	COG3250	beta-galactosidase activity
EE52_RS06685	COG3507	Belongs to the glycosyl hydrolase 43 family
EE52_RS06700	COG4771	TonB-dependent receptor
EE52_RS06715	COG2226	methyltransferase
EE52_RS06725	COG0628	permease
EE52_RS06730	COG1435	thymidine kinase activity
EE52_RS06740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EE52_RS06755	COG2095	MarC family integral membrane protein
EE52_RS06765	COG1629	transport
EE52_RS06770	COG4974	Belongs to the 'phage' integrase family
EE52_RS06780	COG4771	TonB-dependent receptor
EE52_RS06785	COG0702	epimerase
EE52_RS06790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EE52_RS06810	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EE52_RS06810	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EE52_RS06830	COG0531	amino acid
EE52_RS06840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EE52_RS06845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS06850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS06890	COG1162	GTPase activity
EE52_RS06895	COG0233	cytoplasmic translational termination
EE52_RS06915	COG0443	Heat shock 70 kDa protein
EE52_RS06925	COG0528	UMP kinase activity
EE52_RS06930	COG0534	Mate efflux family protein
EE52_RS06955	COG0792	nuclease activity
EE52_RS06975	COG1183	phosphatidylcholine synthase activity
EE52_RS06980	COG0688	phosphatidylethanolamine metabolic process
EE52_RS06990	COG3118	belongs to the thioredoxin family
EE52_RS07025	COG0714	Associated with various cellular activities
EE52_RS07040	COG0802	atpase or kinase
EE52_RS07045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EE52_RS07055	COG2234	aminopeptidase activity
EE52_RS07080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EE52_RS07090	COG0784	Response regulator, receiver
EE52_RS07090	COG2205	protein histidine kinase activity
EE52_RS07105	COG1566	PFAM secretion protein HlyD family protein
EE52_RS07125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EE52_RS07140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EE52_RS07145	COG0742	ribosomal rna small subunit methyltransferase
EE52_RS07170	COG4771	TonB-dependent receptor
EE52_RS07180	COG3537	Alpha-1,2-mannosidase
EE52_RS07195	COG3537	Alpha-1,2-mannosidase
EE52_RS07200	COG2814	Major facilitator Superfamily
EE52_RS07225	COG0739	heme binding
EE52_RS07235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EE52_RS07240	COG3942	CHAP domain
EE52_RS07240	COG1388	LysM domain
EE52_RS07250	COG1475	DNA binding
EE52_RS07255	COG1192	Involved in chromosome partitioning
EE52_RS07265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EE52_RS07270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EE52_RS07285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EE52_RS07290	COG0799	negative regulation of ribosome biogenesis
EE52_RS07315	COG2239	Acts as a magnesium transporter
EE52_RS07320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EE52_RS07330	COG2195	Cleaves the N-terminal amino acid of tripeptides
EE52_RS07405	COG0668	transmembrane transport
EE52_RS07410	COG2207	Transcriptional regulator
EE52_RS07410	COG0662	Cupin 2, conserved barrel domain protein
EE52_RS07470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EE52_RS07480	COG2089	acid synthase
EE52_RS07490	COG1083	cytidylyl-transferase
EE52_RS07495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EE52_RS07500	COG1028	Short-chain dehydrogenase reductase Sdr
EE52_RS07505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EE52_RS07575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS07580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE52_RS07605	COG0667	Aldo Keto reductase
EE52_RS07610	COG1472	Belongs to the glycosyl hydrolase 3 family
EE52_RS07615	COG4771	TonB-dependent receptor
EE52_RS07620	COG0702	epimerase
EE52_RS07660	COG5012	cobalamin binding
EE52_RS07670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EE52_RS07675	COG4124	Belongs to the glycosyl hydrolase 26 family
EE52_RS07680	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EE52_RS07685	COG2211	Major facilitator Superfamily
EE52_RS07690	COG2942	2-epimerase
EE52_RS07730	COG1404	Belongs to the peptidase S8 family
EE52_RS07730	COG4412	M6 family metalloprotease domain protein
EE52_RS07740	COG2205	protein histidine kinase activity
EE52_RS07740	COG5002	protein histidine kinase activity
EE52_RS07740	COG0784	Response regulator, receiver
EE52_RS07750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EE52_RS07755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EE52_RS07760	COG0713	ATP synthesis coupled electron transport
EE52_RS07765	COG0839	Belongs to the complex I subunit 6 family
EE52_RS07775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EE52_RS07780	COG0649	NAD binding
EE52_RS07780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EE52_RS07785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EE52_RS07790	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EE52_RS07800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EE52_RS07805	COG0569	domain protein
EE52_RS07810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EE52_RS07845	COG0546	phosphoglycolate phosphatase activity
EE52_RS07850	COG3119	arylsulfatase activity
EE52_RS07865	COG3119	arylsulfatase activity
EE52_RS07875	COG1629	transport
EE52_RS07880	COG3292	Two component regulator propeller
EE52_RS07880	COG2205	protein histidine kinase activity
EE52_RS07880	COG0745	RESPONSE REGULATOR receiver
EE52_RS07885	COG2271	Major facilitator Superfamily
EE52_RS07935	COG0805	protein transport
EE52_RS07940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EE52_RS07945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EE52_RS07965	COG4585	Histidine kinase
EE52_RS07980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EE52_RS07990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EE52_RS07995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EE52_RS07995	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EE52_RS08000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EE52_RS08005	COG1078	dGTPase activity
EE52_RS08010	COG0284	orotidine-5'-phosphate decarboxylase activity
EE52_RS08015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EE52_RS08020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EE52_RS08030	COG1704	LemA family
EE52_RS08045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EE52_RS08050	COG2226	methyltransferase
EE52_RS08055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EE52_RS08060	COG1702	phosphate starvation-inducible protein PhoH
EE52_RS08070	COG2268	Band 7 protein
EE52_RS08080	COG5434	Belongs to the glycosyl hydrolase 28 family
EE52_RS08090	COG0101	tRNA pseudouridine synthase activity
EE52_RS08110	COG3250	beta-galactosidase activity
EE52_RS08115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EE52_RS08140	COG0457	Tetratricopeptide repeat
EE52_RS08145	COG2814	Major facilitator Superfamily
EE52_RS08170	COG0702	epimerase
EE52_RS08175	COG1629	transport
EE52_RS08175	COG4206	TonB-dependent receptor
EE52_RS08190	COG4771	TonB-dependent receptor
EE52_RS08200	COG1629	transport
EE52_RS08200	COG4206	TonB-dependent receptor
EE52_RS08210	COG0673	inositol 2-dehydrogenase activity
EE52_RS08250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EE52_RS08255	COG0793	Belongs to the peptidase S41A family
EE52_RS08260	COG2131	deaminase
EE52_RS08270	COG0339	signal peptide processing
EE52_RS08280	COG1970	mechanosensitive ion channel activity
EE52_RS08285	COG0519	Catalyzes the synthesis of GMP from XMP
EE52_RS08285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EE52_RS08295	COG4771	TonB-dependent receptor
EE52_RS08300	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EE52_RS08320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EE52_RS08325	COG1506	peptidase
EE52_RS08325	COG0823	Involved in the tonB-independent uptake of proteins
EE52_RS08345	COG0110	maltose O-acetyltransferase activity
EE52_RS08380	COG2873	o-acetylhomoserine
EE52_RS08415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS08435	COG0516	GMP reductase activity
EE52_RS08435	COG0517	IMP dehydrogenase activity
EE52_RS08440	COG2207	Transcriptional regulator
EE52_RS08445	COG0784	Response regulator, receiver
EE52_RS08445	COG5002	protein histidine kinase activity
EE52_RS08445	COG2205	protein histidine kinase activity
EE52_RS08455	COG1335	isochorismatase
EE52_RS08465	COG4977	sequence-specific DNA binding
EE52_RS08465	COG1917	Cupin 2, conserved barrel domain protein
EE52_RS08470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EE52_RS08475	COG0511	ligase activity, forming carbon-carbon bonds
EE52_RS08480	COG0439	Biotin carboxylase
EE52_RS08485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EE52_RS08485	COG4651	solute:proton antiporter activity
EE52_RS08490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EE52_RS08495	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EE52_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
EE52_RS08530	COG1401	restriction endodeoxyribonuclease activity
EE52_RS08550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EE52_RS08555	COG2198	Histidine kinase
EE52_RS08555	COG2205	protein histidine kinase activity
EE52_RS08555	COG0784	Response regulator, receiver
EE52_RS08560	COG2910	NAD(P)H-binding
EE52_RS08565	COG2176	DNA-directed DNA polymerase activity
EE52_RS08575	COG4864	UPF0365 protein
EE52_RS08590	COG0037	tRNA processing
EE52_RS08600	COG1477	protein flavinylation
EE52_RS08605	COG1971	Probably functions as a manganese efflux pump
EE52_RS08620	COG0463	Glycosyl transferase, family 2
EE52_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
EE52_RS08650	COG1917	Cupin 2, conserved barrel domain protein
EE52_RS08650	COG2207	Transcriptional regulator
EE52_RS08745	COG0776	regulation of translation
EE52_RS08800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EE52_RS08805	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EE52_RS08810	COG1663	tetraacyldisaccharide 4'-kinase activity
EE52_RS08815	COG0616	signal peptide processing
EE52_RS08865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EE52_RS08870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EE52_RS08875	COG0066	3-isopropylmalate dehydratase activity
EE52_RS08890	COG0463	Glycosyl transferase, family 2
EE52_RS08920	COG1629	transport
EE52_RS08920	COG4206	TonB-dependent receptor
EE52_RS08925	COG0702	epimerase
EE52_RS08930	COG0671	phosphoesterase, PA-phosphatase related
EE52_RS08940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EE52_RS08955	COG0514	ATP-dependent DNA helicase (RecQ)
EE52_RS08990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EE52_RS09025	COG0823	Involved in the tonB-independent uptake of proteins
EE52_RS09025	COG1506	peptidase
EE52_RS09030	COG3537	Alpha-1,2-mannosidase
EE52_RS09075	COG2326	polyphosphate kinase activity
EE52_RS09115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EE52_RS09120	COG0459	protein refolding
EE52_RS09145	COG0028	Belongs to the TPP enzyme family
EE52_RS09195	COG2194	sulfuric ester hydrolase activity
EE52_RS09215	COG0484	heat shock protein binding
EE52_RS09235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EE52_RS09255	COG0702	epimerase
EE52_RS09260	COG1629	transport
EE52_RS09260	COG4206	TonB-dependent receptor
EE52_RS09265	COG4948	Mandelate Racemase Muconate Lactonizing
EE52_RS09280	COG0702	epimerase
EE52_RS09305	COG3015	lipoprotein NlpE involved in copper resistance
EE52_RS09330	COG0475	glutathione-regulated potassium exporter activity
EE52_RS09335	COG1752	Esterase of the alpha-beta hydrolase superfamily
EE52_RS09350	COG0738	Major facilitator superfamily
EE52_RS09365	COG4804	nuclease activity
EE52_RS09435	COG1621	beta-fructofuranosidase activity
EE52_RS09445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EE52_RS09445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EE52_RS09450	COG3292	Two component regulator propeller
EE52_RS09450	COG0745	RESPONSE REGULATOR receiver
EE52_RS09450	COG2205	protein histidine kinase activity
EE52_RS09465	COG4176	ABC-type proline glycine betaine transport system permease component
EE52_RS09470	COG2113	Glycine betaine
EE52_RS09520	COG3850	Histidine kinase
EE52_RS09520	COG4999	Histidine kinase
EE52_RS09520	COG2205	protein histidine kinase activity
EE52_RS09520	COG3437	response regulator, receiver
EE52_RS09525	COG1649	PFAM Uncharacterised BCR, COG1649
EE52_RS09535	COG1966	Carbon starvation protein
EE52_RS09555	COG1649	PFAM Uncharacterised BCR, COG1649
EE52_RS09570	COG2205	protein histidine kinase activity
EE52_RS09570	COG3292	Two component regulator propeller
EE52_RS09570	COG0745	RESPONSE REGULATOR receiver
EE52_RS09575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EE52_RS09575	COG0047	phosphoribosylformylglycinamidine synthase activity
EE52_RS09605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS09610	COG1554	hydrolase, family 65, central catalytic
EE52_RS09690	COG1609	Transcriptional regulator
EE52_RS09695	COG4206	TonB-dependent receptor
EE52_RS09695	COG1629	transport
EE52_RS09700	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EE52_RS09720	COG5002	protein histidine kinase activity
EE52_RS09725	COG0254	rRNA binding
EE52_RS09735	COG0191	fructose-bisphosphate aldolase activity
EE52_RS09755	COG0366	Alpha amylase catalytic
EE52_RS09770	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EE52_RS09775	COG0511	ligase activity, forming carbon-carbon bonds
EE52_RS09775	COG5016	pyruvate
EE52_RS09785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EE52_RS09800	COG0288	reversible hydration of carbon dioxide
EE52_RS09805	COG0778	Nitroreductase
EE52_RS09820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EE52_RS09825	COG0424	maF-like protein
EE52_RS09905	COG0085	RNA polymerase activity
EE52_RS09925	COG1061	Type III restriction enzyme res subunit
EE52_RS10180	COG4584	PFAM Integrase catalytic
EE52_RS10185	COG1484	DNA-dependent DNA replication
EE52_RS10250	COG1185	polyribonucleotide nucleotidyltransferase activity
EE52_RS10260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EE52_RS10425	COG2311	Membrane
EE52_RS10440	COG0126	phosphoglycerate kinase activity
EE52_RS10455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EE52_RS10475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EE52_RS10480	COG1523	belongs to the glycosyl hydrolase 13 family
EE52_RS10495	COG4206	TonB-dependent receptor
EE52_RS10495	COG1629	transport
EE52_RS10505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS10510	COG3119	arylsulfatase activity
EE52_RS10515	COG1119	ATPase activity
EE52_RS10520	COG0588	phosphoglycerate mutase activity
EE52_RS10525	COG1830	Aldolase
EE52_RS10530	COG3292	Two component regulator propeller
EE52_RS10530	COG2205	protein histidine kinase activity
EE52_RS10530	COG0745	RESPONSE REGULATOR receiver
EE52_RS10535	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS10540	COG3119	arylsulfatase activity
EE52_RS10545	COG3119	arylsulfatase activity
EE52_RS10550	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS10555	COG3250	beta-galactosidase activity
EE52_RS10565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EE52_RS10570	COG0668	transmembrane transport
EE52_RS10580	COG2195	Cleaves the N-terminal amino acid of tripeptides
EE52_RS10620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EE52_RS10685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EE52_RS10690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EE52_RS10695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EE52_RS10700	COG0534	Mate efflux family protein
EE52_RS10705	COG2202	Pas domain
EE52_RS10705	COG2205	protein histidine kinase activity
EE52_RS10755	COG1083	cytidylyl-transferase
EE52_RS10760	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EE52_RS10765	COG2089	acid synthase
EE52_RS10770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EE52_RS10780	COG2244	polysaccharide biosynthetic process
EE52_RS10840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EE52_RS10850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EE52_RS10860	COG1295	ribonuclease BN
EE52_RS10870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EE52_RS10905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EE52_RS10910	COG0646	methionine synthase
EE52_RS10910	COG1410	methionine synthase
EE52_RS10920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EE52_RS10925	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EE52_RS10930	COG0572	uridine kinase
EE52_RS10940	COG4232	protein-disulfide reductase activity
EE52_RS10945	COG1741	Belongs to the pirin family
EE52_RS10955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EE52_RS10960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EE52_RS10970	COG0131	Imidazoleglycerol-phosphate dehydratase
EE52_RS10970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EE52_RS10985	COG4206	TonB-dependent receptor
EE52_RS10985	COG1629	transport
EE52_RS10995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EE52_RS10995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EE52_RS11000	COG0339	signal peptide processing
EE52_RS11005	COG3152	Membrane
EE52_RS11015	COG1773	rubredoxin
EE52_RS11015	COG1592	Rubrerythrin
EE52_RS11050	COG3591	Belongs to the peptidase S1B family
EE52_RS11055	COG3591	Belongs to the peptidase S1B family
EE52_RS11060	COG0641	radical SAM
EE52_RS11200	COG0776	regulation of translation
EE52_RS11260	COG2755	lipolytic protein G-D-S-L family
EE52_RS11260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EE52_RS11345	COG1132	(ABC) transporter
EE52_RS11440	COG0739	heme binding
EE52_RS11440	COG1196	nuclear chromosome segregation
EE52_RS11440	COG0741	lytic transglycosylase activity
EE52_RS11510	COG0741	lytic transglycosylase activity
EE52_RS11510	COG1196	nuclear chromosome segregation
EE52_RS11510	COG0739	heme binding
EE52_RS11555	COG4771	TonB-dependent receptor
EE52_RS11595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EE52_RS11600	COG1733	regulation of RNA biosynthetic process
EE52_RS11605	COG1538	Outer membrane efflux protein
EE52_RS11625	COG3275	phosphorelay sensor kinase activity
EE52_RS11670	COG0629	single-stranded DNA binding
EE52_RS11675	COG1192	Involved in chromosome partitioning
EE52_RS11695	COG1475	DNA binding
EE52_RS11750	COG0805	protein transport
EE52_RS11755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EE52_RS11770	COG0667	Aldo Keto reductase
EE52_RS11780	COG0697	spore germination
EE52_RS11795	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EE52_RS11895	COG0202	RNA polymerase activity
EE52_RS11950	COG4974	Belongs to the 'phage' integrase family
EE52_RS12010	COG0681	Belongs to the peptidase S26 family
EE52_RS12045	COG0420	3'-5' exonuclease activity
EE52_RS12055	COG1132	(ABC) transporter
EE52_RS12060	COG1132	(ABC) transporter
EE52_RS12065	COG1408	metallophosphoesterase
EE52_RS12105	COG0646	methionine synthase
EE52_RS12105	COG1410	methionine synthase
EE52_RS12110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EE52_RS12115	COG0463	Glycosyl transferase, family 2
EE52_RS12120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EE52_RS12125	COG1032	radical SAM domain protein
EE52_RS12165	COG0363	glucosamine-6-phosphate deaminase activity
EE52_RS12225	COG1629	transport
EE52_RS12225	COG4206	TonB-dependent receptor
EE52_RS12230	COG0561	phosphatase activity
EE52_RS12335	COG3326	Membrane
EE52_RS12345	COG1401	restriction endodeoxyribonuclease activity
EE52_RS12350	COG0494	nUDIX hydrolase
EE52_RS12365	COG0693	protein deglycase activity
EE52_RS12375	COG4977	sequence-specific DNA binding
EE52_RS12375	COG1917	Cupin 2, conserved barrel domain protein
EE52_RS12415	COG3586	endonuclease activity
EE52_RS12440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EE52_RS12445	COG0107	imidazoleglycerol-phosphate synthase activity
EE52_RS12450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EE52_RS12450	COG0140	phosphoribosyl-ATP diphosphatase activity
EE52_RS12455	COG2884	Cell division ATP-binding protein ftsE
EE52_RS12460	COG0527	aspartate kinase activity
EE52_RS12465	COG0019	diaminopimelate decarboxylase activity
EE52_RS12570	COG0156	8-amino-7-oxononanoate synthase activity
EE52_RS12580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS12595	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EE52_RS12595	COG0321	lipoyl(octanoyl) transferase activity
EE52_RS12610	COG0592	DNA-directed DNA polymerase activity
EE52_RS12615	COG5002	protein histidine kinase activity
EE52_RS12615	COG2176	DNA-directed DNA polymerase activity
EE52_RS12625	COG0497	DNA recombination
EE52_RS12650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EE52_RS12675	COG2172	sigma factor antagonist activity
EE52_RS12690	COG5002	protein histidine kinase activity
EE52_RS12755	COG0167	dihydroorotate dehydrogenase activity
EE52_RS12760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EE52_RS12805	COG1363	Peptidase, m42
EE52_RS12825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EE52_RS12875	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EE52_RS12885	COG1216	Glycosyl transferase, family 2
EE52_RS12905	COG1216	Glycosyl transferase, family 2
EE52_RS12925	COG1216	Glycosyl transferase, family 2
EE52_RS12925	COG1442	glycosyl transferase family 8
EE52_RS12930	COG1215	transferase activity, transferring glycosyl groups
EE52_RS12945	COG1216	Glycosyl transferase, family 2
EE52_RS12970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EE52_RS13000	COG3023	N-Acetylmuramoyl-L-alanine amidase
EE52_RS13035	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EE52_RS13060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EE52_RS13070	COG0573	inorganic phosphate transmembrane transporter activity
EE52_RS13075	COG0581	inorganic phosphate transmembrane transporter activity
EE52_RS13080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EE52_RS13085	COG0704	Plays a role in the regulation of phosphate uptake
EE52_RS13095	COG0778	Nitroreductase
EE52_RS13100	COG1295	ribonuclease BN
EE52_RS13115	COG4948	Mandelate Racemase Muconate Lactonizing
EE52_RS13125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EE52_RS13135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EE52_RS13160	COG5002	protein histidine kinase activity
EE52_RS13165	COG0745	RESPONSE REGULATOR receiver
EE52_RS13225	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
EE52_RS13245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EE52_RS13255	COG0058	SHG alpha-glucan phosphorylase activity
EE52_RS13270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EE52_RS13280	COG1176	ABC-type spermidine putrescine transport system, permease component I
EE52_RS13285	COG1177	transmembrane transport
EE52_RS13295	COG0724	RNA recognition motif
EE52_RS13310	COG0228	four-way junction DNA binding
EE52_RS13330	COG1690	Belongs to the RtcB family
EE52_RS13335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EE52_RS13380	COG0242	peptide deformylase activity
EE52_RS13385	COG0745	RESPONSE REGULATOR receiver
EE52_RS13390	COG5002	protein histidine kinase activity
EE52_RS13400	COG2205	protein histidine kinase activity
EE52_RS13400	COG2198	Histidine kinase
EE52_RS13400	COG0784	Response regulator, receiver
EE52_RS13400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EE52_RS13410	COG1733	regulation of RNA biosynthetic process
EE52_RS13420	COG1609	Transcriptional regulator
EE52_RS13435	COG3610	response to peptide
EE52_RS13465	COG4771	TonB-dependent receptor
EE52_RS13485	COG1230	cation diffusion facilitator family transporter
EE52_RS13495	COG1566	PFAM secretion protein HlyD family protein
EE52_RS13500	COG2814	Major facilitator Superfamily
EE52_RS13515	COG4771	TonB-dependent receptor
EE52_RS13525	COG1858	cytochrome C peroxidase
EE52_RS13550	COG0716	FMN binding
EE52_RS13555	COG0138	bifunctional purine biosynthesis protein purh
EE52_RS13565	COG2197	response regulator
EE52_RS13570	COG0110	maltose O-acetyltransferase activity
EE52_RS13580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EE52_RS13585	COG3292	Two component regulator propeller
EE52_RS13585	COG0745	RESPONSE REGULATOR receiver
EE52_RS13585	COG2205	protein histidine kinase activity
EE52_RS13595	COG0252	asparaginase activity
EE52_RS13600	COG0159	tryptophan synthase activity
EE52_RS13605	COG0135	phosphoribosylanthranilate isomerase activity
EE52_RS13610	COG0134	indole-3-glycerol-phosphate synthase activity
EE52_RS13625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EE52_RS13630	COG0133	tryptophan synthase activity
EE52_RS13645	COG1979	alcohol dehydrogenase
EE52_RS13655	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EE52_RS13685	COG3275	phosphorelay sensor kinase activity
EE52_RS13700	COG0367	asparagine synthase
EE52_RS13710	COG0067	glutamate synthase
EE52_RS13710	COG0070	glutamate synthase
EE52_RS13710	COG0069	glutamate synthase activity
EE52_RS13725	COG0505	Belongs to the CarA family
EE52_RS13730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EE52_RS13765	COG1131	(ABC) transporter
EE52_RS13770	COG0842	Transport permease protein
EE52_RS13775	COG0842	Transport permease protein
EE52_RS13780	COG2198	Histidine kinase
EE52_RS13780	COG0784	Response regulator, receiver
EE52_RS13780	COG2205	protein histidine kinase activity
EE52_RS13795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EE52_RS13815	COG2949	membrane
EE52_RS13820	COG0556	nucleotide-excision repair
EE52_RS13825	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EE52_RS13855	COG1388	LysM domain
EE52_RS13855	COG3942	CHAP domain
EE52_RS13865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EE52_RS13880	COG1695	Transcriptional regulator
EE52_RS13890	COG0110	maltose O-acetyltransferase activity
EE52_RS13905	COG0823	Involved in the tonB-independent uptake of proteins
EE52_RS13905	COG1506	peptidase
EE52_RS13910	COG0534	Mate efflux family protein
EE52_RS13920	COG0504	CTP synthase activity
EE52_RS13945	COG4656	Part of a membrane complex involved in electron transport
EE52_RS13950	COG4658	electron transport chain
EE52_RS13955	COG4659	FMN binding
EE52_RS13960	COG4660	Part of a membrane complex involved in electron transport
EE52_RS13965	COG4657	Part of a membrane complex involved in electron transport
EE52_RS13970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EE52_RS13985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EE52_RS13990	COG0305	Participates in initiation and elongation during chromosome replication
EE52_RS14030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EE52_RS14040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS14045	COG0028	Belongs to the TPP enzyme family
EE52_RS14065	COG1216	Glycosyl transferase, family 2
EE52_RS14070	COG1216	Glycosyl transferase, family 2
EE52_RS14080	COG1216	Glycosyl transferase, family 2
EE52_RS14090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS14095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE52_RS14100	COG0072	phenylalanine-tRNA ligase activity
EE52_RS14100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EE52_RS14105	COG0217	transcriptional regulatory protein
EE52_RS14120	COG1914	H( )-stimulated, divalent metal cation uptake system
EE52_RS14125	COG0708	Exodeoxyribonuclease III
EE52_RS14145	COG0481	GTPase activity
EE52_RS14155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EE52_RS14180	COG0024	Methionine aminopeptidase
EE52_RS14195	COG0564	pseudouridine synthase activity
EE52_RS14200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EE52_RS14205	COG0574	Belongs to the PEP-utilizing enzyme family
EE52_RS14205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EE52_RS14220	COG0352	thiamine-phosphate diphosphorylase activity
EE52_RS14225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EE52_RS14240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EE52_RS14245	COG2022	thiamine diphosphate biosynthetic process
EE52_RS14250	COG0352	thiamine-phosphate diphosphorylase activity
EE52_RS14305	COG3023	N-Acetylmuramoyl-L-alanine amidase
EE52_RS14315	COG0305	Participates in initiation and elongation during chromosome replication
EE52_RS14420	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
EE52_RS14445	COG4774	siderophore transport
EE52_RS14455	COG4771	TonB-dependent receptor
EE52_RS14465	COG2966	Psort location CytoplasmicMembrane, score
EE52_RS14480	COG1797	cobyrinic acid a,c-diamide synthase activity
EE52_RS14485	COG2096	Adenosyltransferase
EE52_RS14505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS14540	COG1492	cobalamin metabolic process
EE52_RS14550	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EE52_RS14565	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EE52_RS14585	COG4946	Tricorn protease homolog
EE52_RS14585	COG0793	Belongs to the peptidase S41A family
EE52_RS14600	COG0442	prolyl-tRNA aminoacylation
EE52_RS14615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EE52_RS14620	COG1546	Belongs to the CinA family
EE52_RS14620	COG1058	Belongs to the CinA family
EE52_RS14625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EE52_RS14630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EE52_RS14640	COG0552	protein localization to endoplasmic reticulum
EE52_RS14645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EE52_RS14655	COG1652	LysM domain
EE52_RS14660	COG0714	Associated with various cellular activities
EE52_RS14675	COG2304	oxidoreductase activity
EE52_RS14720	COG0542	response to heat
EE52_RS14725	COG0326	Molecular chaperone. Has ATPase activity
EE52_RS14760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EE52_RS14765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EE52_RS14770	COG0336	Belongs to the RNA methyltransferase TrmD family
EE52_RS14775	COG0167	dihydroorotate dehydrogenase activity
EE52_RS14780	COG0543	2 iron, 2 sulfur cluster binding
EE52_RS14800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EE52_RS14830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EE52_RS14855	COG1136	(ABC) transporter
EE52_RS14855	COG0577	efflux transmembrane transporter activity
EE52_RS14880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EE52_RS14885	COG1597	lipid kinase activity
EE52_RS14890	COG0156	8-amino-7-oxononanoate synthase activity
EE52_RS14965	COG0577	efflux transmembrane transporter activity
EE52_RS14965	COG1136	(ABC) transporter
EE52_RS15015	COG2204	response regulator
EE52_RS15075	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EE52_RS15080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EE52_RS15105	COG3830	Belongs to the UPF0237 family
EE52_RS15105	COG0560	Phosphoserine phosphatase
EE52_RS15110	COG0513	Belongs to the DEAD box helicase family
EE52_RS15140	COG1904	glucuronate isomerase
EE52_RS15150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EE52_RS15200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EE52_RS15215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EE52_RS15225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EE52_RS15250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EE52_RS15255	COG1858	cytochrome C peroxidase
EE52_RS15260	COG0724	RNA recognition motif
EE52_RS15265	COG0450	alkyl hydroperoxide reductase
EE52_RS15270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EE52_RS15270	COG3153	acetyltransferase
EE52_RS15280	COG2814	Major facilitator Superfamily
EE52_RS15280	COG0477	Major facilitator Superfamily
EE52_RS15300	COG0351	phosphomethylpyrimidine kinase
EE52_RS15305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EE52_RS15340	COG3385	transposase activity
EE52_RS15390	COG4974	Belongs to the 'phage' integrase family
EE52_RS15595	COG1475	DNA binding
EE52_RS15620	COG4974	Belongs to the 'phage' integrase family
EE52_RS15700	COG3385	transposase activity
EE52_RS15740	COG0681	Belongs to the peptidase S26 family
EE52_RS15775	COG0784	Response regulator, receiver
EE52_RS15775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EE52_RS15775	COG2198	Histidine kinase
EE52_RS15775	COG2205	protein histidine kinase activity
EE52_RS15810	COG1040	competence protein
EE52_RS15825	COG4974	Belongs to the 'phage' integrase family
EE52_RS15830	COG0045	succinate-CoA ligase (ADP-forming) activity
EE52_RS15835	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EE52_RS15850	COG0671	phosphoesterase, PA-phosphatase related
EE52_RS15870	COG2223	nitrite transmembrane transporter activity
EE52_RS15885	COG0673	inositol 2-dehydrogenase activity
EE52_RS15910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EE52_RS15915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EE52_RS15925	COG2135	peptidase activity
EE52_RS15970	COG4584	PFAM Integrase catalytic
EE52_RS15975	COG1484	DNA-dependent DNA replication
EE52_RS16095	COG2205	protein histidine kinase activity
EE52_RS16100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EE52_RS16115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EE52_RS16125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EE52_RS16145	COG1629	transport
EE52_RS16145	COG4206	TonB-dependent receptor
EE52_RS16155	COG2837	iron assimilation
EE52_RS16185	COG2431	L-lysine efflux transmembrane transporter activity
EE52_RS16195	COG0540	Belongs to the ATCase OTCase family
EE52_RS16200	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EE52_RS16215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EE52_RS16225	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EE52_RS16230	COG2205	protein histidine kinase activity
EE52_RS16230	COG2202	Pas domain
EE52_RS16305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EE52_RS16380	COG0776	regulation of translation
EE52_RS16420	COG0741	lytic transglycosylase activity
EE52_RS16420	COG1196	nuclear chromosome segregation
EE52_RS16420	COG0739	heme binding
EE52_RS16460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EE52_RS16480	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EE52_RS16530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EE52_RS16545	COG1064	alcohol dehydrogenase
EE52_RS16550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EE52_RS16570	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EE52_RS16575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EE52_RS16615	COG1091	dTDP-4-dehydrorhamnose reductase activity
EE52_RS16620	COG1120	ATPase activity
EE52_RS16655	COG5002	protein histidine kinase activity
EE52_RS16660	COG0745	RESPONSE REGULATOR receiver
EE52_RS16680	COG3118	belongs to the thioredoxin family
EE52_RS16685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EE52_RS16690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EE52_RS16695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EE52_RS16700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EE52_RS16705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EE52_RS16710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EE52_RS16715	COG0356	it plays a direct role in the translocation of protons across the membrane
EE52_RS16725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EE52_RS16735	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EE52_RS16755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EE52_RS16770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EE52_RS16775	COG0657	acetylesterase activity
EE52_RS16775	COG2755	lipolytic protein G-D-S-L family
EE52_RS16780	COG0167	dihydroorotate dehydrogenase activity
EE52_RS16800	COG0534	Mate efflux family protein
EE52_RS16810	COG1136	(ABC) transporter
EE52_RS16820	COG1136	(ABC) transporter
EE52_RS16820	COG0577	efflux transmembrane transporter activity
EE52_RS16825	COG1136	(ABC) transporter
EE52_RS16825	COG0577	efflux transmembrane transporter activity
EE52_RS16845	COG2204	response regulator
EE52_RS16860	COG1151	hydroxylamine reductase activity
EE52_RS16870	COG3263	regulation of cellular component size
EE52_RS16875	COG1022	Amp-dependent synthetase and ligase
EE52_RS16895	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EE52_RS17035	COG4974	Belongs to the 'phage' integrase family
EE52_RS17045	COG4206	TonB-dependent receptor
EE52_RS17045	COG1629	transport
EE52_RS17055	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS17070	COG0745	RESPONSE REGULATOR receiver
EE52_RS17075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS17120	COG1475	DNA binding
EE52_RS17125	COG3969	phosphoadenosine phosphosulfate
EE52_RS17160	COG0681	Belongs to the peptidase S26 family
EE52_RS17180	COG3119	arylsulfatase activity
EE52_RS17190	COG4771	TonB-dependent receptor
EE52_RS17235	COG1678	Uncharacterized ACR, COG1678
EE52_RS17250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EE52_RS17260	COG1755	Isoprenylcysteine carboxyl methyltransferase
EE52_RS17270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EE52_RS17285	COG1136	(ABC) transporter
EE52_RS17300	COG2204	response regulator
EE52_RS17305	COG3852	Histidine kinase
EE52_RS17325	COG0321	lipoyl(octanoyl) transferase activity
EE52_RS17335	COG2217	Heavy metal translocating P-type atpase
EE52_RS17365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EE52_RS17370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EE52_RS17370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EE52_RS17375	COG0778	Nitroreductase
EE52_RS17385	COG1739	Uncharacterized protein family UPF0029
EE52_RS17390	COG0545	Peptidyl-prolyl cis-trans isomerase
EE52_RS17400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EE52_RS17405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EE52_RS17435	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EE52_RS17440	COG1805	sodium ion transport
EE52_RS17445	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EE52_RS17475	COG1215	transferase activity, transferring glycosyl groups
EE52_RS17490	COG1216	Glycosyl transferase, family 2
EE52_RS17490	COG1442	glycosyl transferase family 8
EE52_RS17495	COG2244	polysaccharide biosynthetic process
EE52_RS17510	COG0438	transferase activity, transferring glycosyl groups
EE52_RS17525	COG0784	Response regulator, receiver
EE52_RS17525	COG2205	protein histidine kinase activity
EE52_RS17525	COG5002	protein histidine kinase activity
EE52_RS17545	COG0488	(ABC) transporter
EE52_RS17565	COG3279	Response regulator of the LytR AlgR family
EE52_RS17635	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EE52_RS17655	COG2003	Belongs to the UPF0758 family
EE52_RS17815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EE52_RS17815	COG0551	DNA topoisomerase type I activity
EE52_RS17905	COG4974	Belongs to the 'phage' integrase family
EE52_RS18000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EE52_RS18005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EE52_RS18050	COG4771	TonB-dependent receptor
EE52_RS18080	COG4771	TonB-dependent receptor
EE52_RS18085	COG2814	Major facilitator Superfamily
EE52_RS18090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EE52_RS18095	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EE52_RS18105	COG0656	L-ascorbic acid biosynthetic process
EE52_RS18145	COG0697	spore germination
EE52_RS18155	COG2885	chlorophyll binding
EE52_RS18155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EE52_RS18160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EE52_RS18170	COG1629	transport
EE52_RS18170	COG4206	TonB-dependent receptor
EE52_RS18180	COG1595	DNA-templated transcription, initiation
EE52_RS18185	COG1704	LemA family
EE52_RS18190	COG0501	Belongs to the peptidase M48B family
EE52_RS18215	COG3250	beta-galactosidase activity
EE52_RS18220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EE52_RS18225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EE52_RS18235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EE52_RS18250	COG3831	ATPase activity
EE52_RS18250	COG4884	unkown
EE52_RS18285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS18290	COG1136	(ABC) transporter
EE52_RS18295	COG0577	efflux transmembrane transporter activity
EE52_RS18295	COG1136	(ABC) transporter
EE52_RS18305	COG3279	Response regulator of the LytR AlgR family
EE52_RS18315	COG0494	nUDIX hydrolase
EE52_RS18320	COG4584	PFAM Integrase catalytic
EE52_RS18325	COG1484	DNA-dependent DNA replication
EE52_RS18405	COG1742	UPF0060 membrane protein
EE52_RS18450	COG0363	glucosamine-6-phosphate deaminase activity
EE52_RS18455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EE52_RS18460	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EE52_RS18465	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EE52_RS18480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE52_RS18500	COG1091	dTDP-4-dehydrorhamnose reductase activity
EE52_RS18510	COG1086	Polysaccharide biosynthesis protein
EE52_RS18535	COG3475	LICD family
EE52_RS18545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EE52_RS18580	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EE52_RS18585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS18590	COG0318	PFAM AMP-dependent synthetase and ligase
EE52_RS18600	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
EE52_RS18610	COG0534	Mate efflux family protein
EE52_RS18640	COG4771	TonB-dependent receptor
EE52_RS18655	COG0534	Mate efflux family protein
EE52_RS18680	COG4771	TonB-dependent receptor
EE52_RS18690	COG1956	GAF domain-containing protein
EE52_RS18695	COG0737	Belongs to the 5'-nucleotidase family
EE52_RS18700	COG2205	protein histidine kinase activity
EE52_RS18700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EE52_RS18705	COG2183	response to ionizing radiation
EE52_RS18730	COG1595	DNA-templated transcription, initiation
EE52_RS18735	COG0488	(ABC) transporter
EE52_RS18740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EE52_RS18745	COG0484	heat shock protein binding
EE52_RS18750	COG0702	epimerase
EE52_RS18755	COG4771	TonB-dependent receptor
EE52_RS18760	COG3250	beta-galactosidase activity
EE52_RS18765	COG3537	Alpha-1,2-mannosidase
EE52_RS18770	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS18780	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS18800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS18835	COG4206	TonB-dependent receptor
EE52_RS18835	COG1629	transport
EE52_RS18840	COG0702	epimerase
EE52_RS18845	COG0702	epimerase
EE52_RS18850	COG4771	TonB-dependent receptor
EE52_RS18860	COG0702	epimerase
EE52_RS18865	COG1629	transport
EE52_RS18885	COG0702	epimerase
EE52_RS18890	COG1629	transport
EE52_RS18895	COG2731	YhcH YjgK YiaL family protein
EE52_RS18900	COG2271	Major facilitator Superfamily
EE52_RS18910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EE52_RS18915	COG1940	carbohydrate kinase activity
EE52_RS18955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EE52_RS18965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EE52_RS18965	COG0674	pyruvate-flavodoxin oxidoreductase activity
EE52_RS18965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EE52_RS18965	COG1013	pyruvate-flavodoxin oxidoreductase activity
EE52_RS18970	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EE52_RS18975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EE52_RS18985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EE52_RS18990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EE52_RS18995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EE52_RS19000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EE52_RS19015	COG0242	peptide deformylase activity
EE52_RS19020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EE52_RS19045	COG4974	Belongs to the 'phage' integrase family
EE52_RS19065	COG2885	chlorophyll binding
EE52_RS19085	COG0175	sulfate reduction
EE52_RS19090	COG0529	Catalyzes the synthesis of activated sulfate
EE52_RS19095	COG0471	metal ion transport
EE52_RS19095	COG3273	potassium ion transport
EE52_RS19105	COG3250	beta-galactosidase activity
EE52_RS19120	COG4221	oxidoreductase activity
EE52_RS19125	COG0513	Belongs to the DEAD box helicase family
EE52_RS19145	COG1482	cell wall glycoprotein biosynthetic process
EE52_RS19160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EE52_RS19165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EE52_RS19170	COG0698	ribose 5-phosphate isomerase
EE52_RS19220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EE52_RS19225	COG0673	inositol 2-dehydrogenase activity
EE52_RS19250	COG0590	tRNA wobble adenosine to inosine editing
EE52_RS19335	COG4584	PFAM Integrase catalytic
EE52_RS19340	COG1484	DNA-dependent DNA replication
EE52_RS19375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EE52_RS19375	COG2198	Histidine kinase
EE52_RS19375	COG2205	protein histidine kinase activity
EE52_RS19375	COG0784	Response regulator, receiver
EE52_RS19395	COG0551	DNA topoisomerase type I activity
EE52_RS19395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EE52_RS19435	COG4974	Belongs to the 'phage' integrase family
EE52_RS19445	COG2264	protein methyltransferase activity
EE52_RS19450	COG0716	FMN binding
EE52_RS19455	COG0022	dehydrogenase e1 component
EE52_RS19460	COG0508	dehydrogenase complex catalyzes the overall conversion of
EE52_RS19495	COG0402	S-adenosylhomocysteine deaminase activity
EE52_RS19500	COG2226	methyltransferase
EE52_RS19510	COG0511	ligase activity, forming carbon-carbon bonds
EE52_RS19515	COG0439	Biotin carboxylase
EE52_RS19520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EE52_RS19530	COG2885	chlorophyll binding
EE52_RS19530	COG3047	cAMP biosynthetic process
EE52_RS19535	COG1620	l-lactate permease
EE52_RS19545	COG4771	TonB-dependent receptor
EE52_RS19575	COG1252	NADH dehydrogenase
EE52_RS19580	COG0577	efflux transmembrane transporter activity
EE52_RS19580	COG1136	(ABC) transporter
EE52_RS19585	COG0577	efflux transmembrane transporter activity
EE52_RS19585	COG1136	(ABC) transporter
EE52_RS19595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE52_RS19615	COG0628	permease
EE52_RS19620	COG1215	transferase activity, transferring glycosyl groups
EE52_RS19625	COG4591	ABC-type transport system involved in lipoprotein release permease component
EE52_RS19630	COG0436	Aminotransferase
EE52_RS19640	COG5492	domain, Protein
EE52_RS19655	COG0488	(ABC) transporter
EE52_RS19680	COG0745	RESPONSE REGULATOR receiver
EE52_RS19705	COG4206	TonB-dependent receptor
EE52_RS19770	COG0629	single-stranded DNA binding
EE52_RS19775	COG3119	arylsulfatase activity
EE52_RS19790	COG1530	ribonuclease E activity
EE52_RS19795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE52_RS19800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS19850	COG2244	polysaccharide biosynthetic process
EE52_RS19865	COG1028	Short-chain dehydrogenase reductase Sdr
EE52_RS19895	COG1088	dTDP-glucose 4,6-dehydratase activity
EE52_RS19905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EE52_RS19955	COG0582	viral genome integration into host DNA
EE52_RS19990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EE52_RS20010	COG4191	Histidine kinase
EE52_RS20015	COG2204	response regulator
EE52_RS20025	COG0784	Response regulator, receiver
EE52_RS20025	COG2205	protein histidine kinase activity
EE52_RS20045	COG1136	(ABC) transporter
EE52_RS20050	COG1136	(ABC) transporter
EE52_RS20065	COG2207	Transcriptional regulator
EE52_RS20065	COG0662	Cupin 2, conserved barrel domain protein
EE52_RS20075	COG1136	(ABC) transporter
EE52_RS20075	COG0577	efflux transmembrane transporter activity
EE52_RS20085	COG0577	efflux transmembrane transporter activity
EE52_RS20095	COG0577	efflux transmembrane transporter activity
EE52_RS20105	COG0577	efflux transmembrane transporter activity
EE52_RS20120	COG1705	Flagellar rod assembly protein muramidase FlgJ
EE52_RS20120	COG1388	LysM domain
EE52_RS20125	COG0295	cytidine deaminase activity
EE52_RS20130	COG2207	Transcriptional regulator
EE52_RS20130	COG0662	Cupin 2, conserved barrel domain protein
EE52_RS20135	COG3059	membrane
EE52_RS20140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EE52_RS20145	COG0488	(ABC) transporter
EE52_RS20190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EE52_RS20210	COG0686	Belongs to the AlaDH PNT family
EE52_RS20235	COG1595	DNA-templated transcription, initiation
EE52_RS20250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EE52_RS20260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EE52_RS20290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EE52_RS20305	COG1741	Belongs to the pirin family
EE52_RS20310	COG0259	pyridoxamine-phosphate oxidase activity
EE52_RS20325	COG0346	lactoylglutathione lyase activity
EE52_RS20340	COG0471	metal ion transport
EE52_RS20340	COG0490	domain, Protein
EE52_RS20360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EE52_RS20365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EE52_RS20370	COG1028	Short-chain dehydrogenase reductase Sdr
EE52_RS20385	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EE52_RS20405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS20430	COG2244	polysaccharide biosynthetic process
EE52_RS20450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EE52_RS20510	COG1918	ferrous iron import across plasma membrane
EE52_RS20510	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EE52_RS20520	COG2373	Large extracellular alpha-helical protein
EE52_RS20525	COG4953	penicillin-binding protein 1C
EE52_RS20530	COG2814	Major facilitator Superfamily
EE52_RS20545	COG1757	Na H antiporter
EE52_RS20565	COG2873	o-acetylhomoserine
EE52_RS20595	COG0501	Belongs to the peptidase M48B family
EE52_RS20600	COG1253	flavin adenine dinucleotide binding
EE52_RS20625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EE52_RS20625	COG2755	lipolytic protein G-D-S-L family
EE52_RS20645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EE52_RS20670	COG0783	Belongs to the Dps family
EE52_RS20675	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EE52_RS20705	COG4771	TonB-dependent receptor
EE52_RS20720	COG1082	Xylose isomerase domain protein TIM barrel
EE52_RS20735	COG4948	Mandelate Racemase Muconate Lactonizing
EE52_RS20740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EE52_RS20750	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EE52_RS20755	COG1169	isochorismate synthase
EE52_RS20760	COG0561	phosphatase activity
EE52_RS20765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EE52_RS20780	COG1280	lysine exporter protein (LysE YggA)
EE52_RS20785	COG4651	solute:proton antiporter activity
EE52_RS20785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EE52_RS20810	COG2207	Transcriptional regulator
EE52_RS20810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EE52_RS20820	COG4206	TonB-dependent receptor
EE52_RS20820	COG1629	transport
EE52_RS20830	COG2855	membrane
EE52_RS20835	COG2217	Heavy metal translocating P-type atpase
EE52_RS20845	COG2885	chlorophyll binding
EE52_RS20855	COG3189	MarR family transcriptional regulator
EE52_RS20860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EE52_RS20865	COG2195	Cleaves the N-terminal amino acid of tripeptides
EE52_RS20870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EE52_RS20875	COG2205	protein histidine kinase activity
EE52_RS20875	COG0784	Response regulator, receiver
EE52_RS20935	COG1193	negative regulation of DNA recombination
EE52_RS20940	COG0598	Magnesium transport protein CorA
EE52_RS20945	COG1760	l-serine dehydratase
EE52_RS20980	COG3634	alkyl hydroperoxide reductase activity
EE52_RS20990	COG1408	metallophosphoesterase
EE52_RS21000	COG1629	transport
EE52_RS21000	COG4206	TonB-dependent receptor
EE52_RS21020	COG1501	Belongs to the glycosyl hydrolase 31 family
EE52_RS21040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EE52_RS21045	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
EE52_RS21050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EE52_RS21060	COG0443	Heat shock 70 kDa protein
EE52_RS21080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EE52_RS21100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EE52_RS21115	COG1595	DNA-templated transcription, initiation
EE52_RS21130	COG2855	membrane
EE52_RS21135	COG0583	DNA-binding transcription factor activity
EE52_RS21145	COG0542	response to heat
EE52_RS21160	COG0237	dephospho-CoA kinase activity
EE52_RS21170	COG1862	Preprotein translocase
EE52_RS21175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EE52_RS21185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EE52_RS21190	COG0193	aminoacyl-tRNA hydrolase activity
EE52_RS21195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EE52_RS21220	COG1082	Xylose isomerase domain protein TIM barrel
EE52_RS21225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EE52_RS21235	COG0148	phosphopyruvate hydratase activity
EE52_RS21250	COG3011	Protein conserved in bacteria
EE52_RS21280	COG1501	Belongs to the glycosyl hydrolase 31 family
EE52_RS21295	COG0564	pseudouridine synthase activity
EE52_RS21300	COG0454	-acetyltransferase
EE52_RS21335	COG1288	antiporter activity
EE52_RS21355	COG2207	Transcriptional regulator
EE52_RS21375	COG2706	6-phosphogluconolactonase activity
EE52_RS21395	COG1496	oxidoreductase activity
EE52_RS21400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EE52_RS21405	COG0563	adenylate kinase activity
EE52_RS21410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EE52_RS21420	COG4771	TonB-dependent receptor
EE52_RS21435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE52_RS21445	COG1215	transferase activity, transferring glycosyl groups
EE52_RS21465	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EE52_RS21480	COG0110	maltose O-acetyltransferase activity
EE52_RS21505	COG2030	dehydratase
EE52_RS21540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EE52_RS21580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EE52_RS21590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EE52_RS21600	COG1253	flavin adenine dinucleotide binding
EE52_RS21620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EE52_RS21630	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
EE52_RS21650	COG3119	arylsulfatase activity
EE52_RS21655	COG3119	arylsulfatase activity
EE52_RS21660	COG0702	epimerase
EE52_RS21665	COG4771	TonB-dependent receptor
EE52_RS21680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EE52_RS21695	COG4771	TonB-dependent receptor
EE52_RS21720	COG0525	valine-tRNA ligase activity
EE52_RS21730	COG3956	TIGRFAM MazG family protein
EE52_RS21745	COG1595	DNA-templated transcription, initiation
EE52_RS21785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS21790	COG0492	ferredoxin-NADP+ reductase activity
EE52_RS21800	COG1674	ftsk spoiiie
EE52_RS21815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EE52_RS21825	COG2211	Major facilitator Superfamily
EE52_RS21845	COG1136	(ABC) transporter
EE52_RS21860	COG1597	lipid kinase activity
EE52_RS21865	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EE52_RS21870	COG0612	Peptidase, M16
EE52_RS21880	COG1131	(ABC) transporter
EE52_RS21885	COG0791	NLP P60 protein
EE52_RS21890	COG0546	phosphoglycolate phosphatase activity
EE52_RS21910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EE52_RS21915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EE52_RS21925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EE52_RS21935	COG0543	2 iron, 2 sulfur cluster binding
EE52_RS21940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EE52_RS21945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EE52_RS21950	COG0297	glycogen (starch) synthase activity
EE52_RS22005	COG0626	cystathionine gamma-synthase activity
EE52_RS22010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EE52_RS22015	COG0561	phosphatase activity
EE52_RS22020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EE52_RS22030	COG0009	L-threonylcarbamoyladenylate synthase
EE52_RS22040	COG0363	glucosamine-6-phosphate deaminase activity
EE52_RS22050	COG1242	4 iron, 4 sulfur cluster binding
EE52_RS22075	COG2076	Multidrug Resistance protein
EE52_RS22115	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EE52_RS22125	COG1388	LysM domain
EE52_RS22125	COG0741	lytic transglycosylase activity
EE52_RS22130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EE52_RS22135	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EE52_RS22135	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EE52_RS22145	COG1285	pathogenesis
EE52_RS22165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EE52_RS22165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EE52_RS22180	COG1115	amino acid carrier protein
EE52_RS22190	COG1509	lysine 2,3-aminomutase activity
EE52_RS22200	COG2233	PERMEase
EE52_RS22215	COG1393	Belongs to the ArsC family
EE52_RS22225	COG1629	transport
EE52_RS22235	COG2304	oxidoreductase activity
EE52_RS22245	COG0351	phosphomethylpyrimidine kinase
EE52_RS22255	COG1139	Iron-sulfur cluster binding protein
EE52_RS22260	COG0247	lactate metabolic process
EE52_RS22265	COG0602	queuosine metabolic process
EE52_RS22275	COG2832	Protein of unknown function (DUF454)
EE52_RS22280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EE52_RS22295	COG3142	Participates in the control of copper homeostasis
EE52_RS22300	COG1418	mRNA catabolic process
EE52_RS22325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EE52_RS22340	COG4771	TonB-dependent receptor
EE52_RS22425	COG1505	serine-type exopeptidase activity
EE52_RS22455	COG0517	IMP dehydrogenase activity
EE52_RS22455	COG0617	tRNA 3'-terminal CCA addition
EE52_RS22455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EE52_RS22465	COG1126	abc transporter atp-binding protein
EE52_RS22475	COG1278	Cold shock
EE52_RS22490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE52_RS22495	COG1216	Glycosyl transferase, family 2
EE52_RS22500	COG0438	transferase activity, transferring glycosyl groups
EE52_RS22525	COG1216	Glycosyl transferase, family 2
EE52_RS22535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EE52_RS22545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE52_RS22575	COG0776	regulation of translation
EE52_RS22585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EE52_RS22620	COG0632	four-way junction helicase activity
EE52_RS22625	COG0673	inositol 2-dehydrogenase activity
EE52_RS22630	COG1272	protein, Hemolysin III
EE52_RS22635	COG1328	CTP reductase activity
EE52_RS22645	COG2814	Major facilitator Superfamily
EE52_RS22655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EE52_RS22665	COG0750	zinc metalloprotease
EE52_RS22670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EE52_RS22680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EE52_RS22685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EE52_RS22695	COG1214	PFAM Peptidase M22, glycoprotease
EE52_RS22700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EE52_RS22700	COG0784	Response regulator, receiver
EE52_RS22700	COG2198	Histidine kinase
EE52_RS22700	COG2205	protein histidine kinase activity
EE52_RS22720	COG0194	GDP metabolic process
EE52_RS22725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EE52_RS22730	COG1408	metallophosphoesterase
EE52_RS22735	COG1575	Belongs to the MenA family. Type 1 subfamily
EE52_RS22740	COG1088	dTDP-glucose 4,6-dehydratase activity
EE52_RS22745	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EE52_RS22755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EE52_RS22765	COG2204	response regulator
EE52_RS22770	COG0488	(ABC) transporter
EE52_RS22805	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EE52_RS22805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EE52_RS22830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EE52_RS22835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EE52_RS22845	COG1522	sequence-specific DNA binding
EE52_RS22870	COG0811	peptide transport
EE52_RS22880	COG0084	hydrolase, TatD family'
EE52_RS22895	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EE52_RS22900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EE52_RS22905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EE52_RS22910	COG0205	6-phosphofructokinase activity
EE52_RS22930	COG0372	Belongs to the citrate synthase family
EE52_RS22935	COG0538	isocitrate dehydrogenase activity
EE52_RS22945	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EE52_RS22955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EE52_RS22980	COG0129	dihydroxy-acid dehydratase activity
EE52_RS23000	COG2885	chlorophyll binding
EE52_RS23020	COG3681	Belongs to the UPF0597 family
EE52_RS23055	COG3119	arylsulfatase activity
EE52_RS23075	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EE52_RS23085	COG0702	epimerase
EE52_RS23090	COG4771	TonB-dependent receptor
EE52_RS23105	COG0702	epimerase
EE52_RS23110	COG4206	TonB-dependent receptor
EE52_RS23110	COG1629	transport
EE52_RS23130	COG4771	TonB-dependent receptor
EE52_RS23160	COG1012	belongs to the aldehyde dehydrogenase family
EE52_RS23190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EE52_RS23190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EE52_RS23195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EE52_RS23225	COG0534	Mate efflux family protein
EE52_RS23245	COG1752	Esterase of the alpha-beta hydrolase superfamily
EE52_RS23255	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EE52_RS23260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EE52_RS23265	COG0166	Belongs to the GPI family
EE52_RS23275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EE52_RS23285	COG2502	aspartate--ammonia ligase
EE52_RS23290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EE52_RS23305	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EE52_RS23330	COG0210	DNA helicase
EE52_RS23340	COG1484	DNA-dependent DNA replication
EE52_RS23350	COG0860	N-Acetylmuramoyl-L-alanine amidase