locus-tag	class	description
HR50_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HR50_RS00020	COG1640	4-alpha-glucanotransferase
HR50_RS00030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HR50_RS00035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR50_RS00060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HR50_RS00065	COG1022	Amp-dependent synthetase and ligase
HR50_RS00085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HR50_RS00090	COG0360	Binds together with S18 to 16S ribosomal RNA
HR50_RS00110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HR50_RS00120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HR50_RS00140	COG4771	TonB-dependent receptor
HR50_RS00155	COG2431	L-lysine efflux transmembrane transporter activity
HR50_RS00185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HR50_RS00190	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HR50_RS00195	COG0386	Belongs to the glutathione peroxidase family
HR50_RS00215	COG3275	phosphorelay sensor kinase activity
HR50_RS00220	COG3279	Response regulator of the LytR AlgR family
HR50_RS00240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HR50_RS00255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HR50_RS00265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HR50_RS00270	COG0658	competence protein
HR50_RS00275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HR50_RS00280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HR50_RS00290	COG0009	L-threonylcarbamoyladenylate synthase
HR50_RS00315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HR50_RS00320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HR50_RS00325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HR50_RS00330	COG0277	FAD linked oxidase domain protein
HR50_RS00330	COG0247	lactate metabolic process
HR50_RS00430	COG2818	Glycosylase
HR50_RS00440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HR50_RS00440	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HR50_RS00445	COG0514	ATP-dependent DNA helicase (RecQ)
HR50_RS00455	COG2271	Major facilitator Superfamily
HR50_RS00470	COG0702	epimerase
HR50_RS00475	COG4771	TonB-dependent receptor
HR50_RS00480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HR50_RS00485	COG2186	Transcriptional regulator
HR50_RS00495	COG0436	Aminotransferase
HR50_RS00500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HR50_RS00515	COG0358	DNA primase activity
HR50_RS00520	COG3119	arylsulfatase activity
HR50_RS00535	COG4771	TonB-dependent receptor
HR50_RS00550	COG0302	gtp cyclohydrolase
HR50_RS00560	COG0149	triose-phosphate isomerase activity
HR50_RS00575	COG0739	heme binding
HR50_RS00580	COG0105	UTP biosynthetic process
HR50_RS00585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HR50_RS00590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HR50_RS00610	COG0811	peptide transport
HR50_RS00620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HR50_RS00695	COG1629	transport
HR50_RS00730	COG0039	L-malate dehydrogenase activity
HR50_RS00765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS00780	COG4948	Mandelate Racemase Muconate Lactonizing
HR50_RS00800	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HR50_RS00805	COG3118	belongs to the thioredoxin family
HR50_RS00810	COG0489	protein tyrosine kinase activity
HR50_RS00825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HR50_RS00830	COG1722	exodeoxyribonuclease VII activity
HR50_RS00835	COG1570	exodeoxyribonuclease VII activity
HR50_RS00845	COG0482	sulfurtransferase activity
HR50_RS00875	COG0179	Fumarylacetoacetate (FAA) hydrolase
HR50_RS00880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HR50_RS00890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HR50_RS00895	COG0052	Belongs to the universal ribosomal protein uS2 family
HR50_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HR50_RS00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HR50_RS00920	COG0017	Asparaginyl-tRNA synthetase
HR50_RS00925	COG1187	pseudouridine synthase activity
HR50_RS00955	COG0110	maltose O-acetyltransferase activity
HR50_RS00960	COG3022	response to hydroperoxide
HR50_RS00965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS01035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HR50_RS01075	COG1216	Glycosyl transferase, family 2
HR50_RS01075	COG1442	glycosyl transferase family 8
HR50_RS01140	COG0745	RESPONSE REGULATOR receiver
HR50_RS01180	COG4680	protein conserved in bacteria
HR50_RS01190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HR50_RS01205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HR50_RS01220	COG0516	GMP reductase activity
HR50_RS01220	COG0517	IMP dehydrogenase activity
HR50_RS01225	COG0514	ATP-dependent DNA helicase (RecQ)
HR50_RS01230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HR50_RS01255	COG0724	RNA recognition motif
HR50_RS01265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HR50_RS01270	COG1127	ABC transporter
HR50_RS01275	COG2197	response regulator
HR50_RS01280	COG1160	GTP binding
HR50_RS01285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HR50_RS01290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HR50_RS01345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HR50_RS01350	COG0470	DNA polymerase III
HR50_RS01355	COG1774	PSP1 C-terminal conserved region
HR50_RS01365	COG0772	Belongs to the SEDS family
HR50_RS01380	COG1792	Involved in formation and maintenance of cell shape
HR50_RS01390	COG0138	bifunctional purine biosynthesis protein purh
HR50_RS01395	COG3590	peptidase
HR50_RS01400	COG0488	(ABC) transporter
HR50_RS01435	COG0784	Response regulator, receiver
HR50_RS01435	COG2205	protein histidine kinase activity
HR50_RS01440	COG0534	Mate efflux family protein
HR50_RS01445	COG0612	Peptidase, M16
HR50_RS01470	COG0564	pseudouridine synthase activity
HR50_RS01515	COG2312	Erythromycin esterase
HR50_RS01535	COG1131	(ABC) transporter
HR50_RS01625	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HR50_RS01640	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HR50_RS01660	COG1696	Membrane protein involved in D-alanine export
HR50_RS01700	COG2986	histidine ammonia-lyase
HR50_RS01710	COG1228	amidohydrolase
HR50_RS01720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HR50_RS01750	COG0203	ribosomal protein L17
HR50_RS01755	COG0202	RNA polymerase activity
HR50_RS01760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HR50_RS01765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HR50_RS01770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HR50_RS01775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HR50_RS01780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HR50_RS01795	COG0200	Binds to the 23S rRNA
HR50_RS01800	COG1841	ribosomal large subunit assembly
HR50_RS01805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HR50_RS01810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HR50_RS01815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HR50_RS01820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HR50_RS01825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HR50_RS01830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HR50_RS01835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HR50_RS01840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HR50_RS01845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HR50_RS01850	COG0255	Belongs to the universal ribosomal protein uL29 family
HR50_RS01855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HR50_RS01860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HR50_RS01865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HR50_RS01870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HR50_RS01875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HR50_RS01880	COG0089	rRNA binding
HR50_RS01885	COG0088	Forms part of the polypeptide exit tunnel
HR50_RS01890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HR50_RS01895	COG0051	transcription antitermination factor activity, RNA binding
HR50_RS01900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HR50_RS01905	COG0049	tRNA binding
HR50_RS01910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HR50_RS01940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HR50_RS01945	COG0085	RNA polymerase activity
HR50_RS01950	COG0222	ribosome binding
HR50_RS01955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HR50_RS01960	COG0081	regulation of translation
HR50_RS01965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HR50_RS02010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HR50_RS02015	COG4974	Belongs to the 'phage' integrase family
HR50_RS02020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HR50_RS02030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HR50_RS02045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HR50_RS02050	COG1480	7TM receptor with intracellular HD hydrolase
HR50_RS02055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HR50_RS02065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HR50_RS02080	COG1027	Aspartate ammonia-lyase
HR50_RS02085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HR50_RS02090	COG0252	asparaginase activity
HR50_RS02105	COG2096	Adenosyltransferase
HR50_RS02175	COG2755	lipolytic protein G-D-S-L family
HR50_RS02175	COG0657	acetylesterase activity
HR50_RS02185	COG3275	phosphorelay sensor kinase activity
HR50_RS02190	COG3279	Response regulator of the LytR AlgR family
HR50_RS02205	COG4206	TonB-dependent receptor
HR50_RS02225	COG2197	response regulator
HR50_RS02245	COG2207	Transcriptional regulator
HR50_RS02245	COG0662	Cupin 2, conserved barrel domain protein
HR50_RS02250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HR50_RS02315	COG4974	Belongs to the 'phage' integrase family
HR50_RS02355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HR50_RS02365	COG1185	polyribonucleotide nucleotidyltransferase activity
HR50_RS02380	COG4771	TonB-dependent receptor
HR50_RS02415	COG3426	butyrate kinase activity
HR50_RS02420	COG0280	phosphate acetyltransferase
HR50_RS02430	COG1619	proteins homologs of microcin C7 resistance protein MccF
HR50_RS02435	COG2234	aminopeptidase activity
HR50_RS02440	COG2166	iron-sulfur cluster assembly
HR50_RS02445	COG3655	Transcriptional regulator
HR50_RS02455	COG1266	CAAX protease self-immunity
HR50_RS02465	COG0196	riboflavin kinase activity
HR50_RS02470	COG1011	Hydrolase
HR50_RS02475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HR50_RS02480	COG2205	protein histidine kinase activity
HR50_RS02480	COG0784	Response regulator, receiver
HR50_RS02485	COG1773	rubredoxin
HR50_RS02490	COG1283	sodium-dependent phosphate transmembrane transporter activity
HR50_RS02500	COG2205	protein histidine kinase activity
HR50_RS02530	COG0006	proline dipeptidase activity
HR50_RS02550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HR50_RS02575	COG0702	epimerase
HR50_RS02580	COG4771	TonB-dependent receptor
HR50_RS02600	COG0793	Belongs to the peptidase S41A family
HR50_RS02605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HR50_RS02640	COG4771	TonB-dependent receptor
HR50_RS02650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HR50_RS02655	COG1882	Formate acetyltransferase
HR50_RS02660	COG2814	Major facilitator Superfamily
HR50_RS02660	COG0477	Major facilitator Superfamily
HR50_RS02680	COG1040	competence protein
HR50_RS02685	COG0483	inositol monophosphate 1-phosphatase activity
HR50_RS02695	COG3345	alpha-galactosidase
HR50_RS02720	COG3475	LICD family
HR50_RS02725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HR50_RS02760	COG1442	glycosyl transferase family 8
HR50_RS02845	COG0018	arginyl-trna synthetase
HR50_RS02875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HR50_RS02880	COG0776	regulation of translation
HR50_RS02920	COG1609	Transcriptional regulator
HR50_RS02920	COG2207	Transcriptional regulator
HR50_RS02940	COG0674	pyruvate-flavodoxin oxidoreductase activity
HR50_RS02940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HR50_RS02945	COG1013	pyruvate-flavodoxin oxidoreductase activity
HR50_RS02955	COG4974	Belongs to the 'phage' integrase family
HR50_RS03035	COG0584	glycerophosphoryl diester phosphodiesterase
HR50_RS03040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HR50_RS03045	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HR50_RS03050	COG1629	transport
HR50_RS03065	COG1629	transport
HR50_RS03080	COG5434	Belongs to the glycosyl hydrolase 28 family
HR50_RS03110	COG1629	transport
HR50_RS03125	COG1217	gtp-binding protein TYPA
HR50_RS03130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HR50_RS03140	COG0318	PFAM AMP-dependent synthetase and ligase
HR50_RS03145	COG5002	protein histidine kinase activity
HR50_RS03145	COG2205	protein histidine kinase activity
HR50_RS03145	COG0784	Response regulator, receiver
HR50_RS03170	COG3119	arylsulfatase activity
HR50_RS03180	COG4206	TonB-dependent receptor
HR50_RS03180	COG1629	transport
HR50_RS03200	COG4591	ABC-type transport system involved in lipoprotein release permease component
HR50_RS03205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HR50_RS03225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HR50_RS03230	COG4974	Belongs to the 'phage' integrase family
HR50_RS03245	COG0606	chelatase, subunit chli
HR50_RS03265	COG2205	protein histidine kinase activity
HR50_RS03265	COG0745	RESPONSE REGULATOR receiver
HR50_RS03265	COG3292	Two component regulator propeller
HR50_RS03320	COG0438	transferase activity, transferring glycosyl groups
HR50_RS03345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HR50_RS03350	COG0438	transferase activity, transferring glycosyl groups
HR50_RS03360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HR50_RS03365	COG0545	Peptidyl-prolyl cis-trans isomerase
HR50_RS03370	COG0545	Peptidyl-prolyl cis-trans isomerase
HR50_RS03375	COG1522	sequence-specific DNA binding
HR50_RS03395	COG3275	phosphorelay sensor kinase activity
HR50_RS03480	COG4206	TonB-dependent receptor
HR50_RS03480	COG1629	transport
HR50_RS03490	COG2814	Major facilitator Superfamily
HR50_RS03495	COG3292	Two component regulator propeller
HR50_RS03495	COG2205	protein histidine kinase activity
HR50_RS03495	COG0745	RESPONSE REGULATOR receiver
HR50_RS03500	COG1621	beta-fructofuranosidase activity
HR50_RS03545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HR50_RS03550	COG3409	Peptidoglycan-binding domain 1 protein
HR50_RS03550	COG0793	Belongs to the peptidase S41A family
HR50_RS03570	COG1053	succinate dehydrogenase
HR50_RS03575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HR50_RS03590	COG4771	TonB-dependent receptor
HR50_RS03620	COG0758	DNA mediated transformation
HR50_RS03620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HR50_RS03630	COG0826	peptidase U32
HR50_RS03640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HR50_RS03655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HR50_RS03660	COG0557	exoribonuclease II activity
HR50_RS03690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HR50_RS03705	COG0012	GTP binding
HR50_RS03710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HR50_RS03715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HR50_RS03725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HR50_RS03740	COG0495	leucyl-tRNA aminoacylation
HR50_RS03745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HR50_RS03760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HR50_RS03780	COG1215	transferase activity, transferring glycosyl groups
HR50_RS03835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HR50_RS03835	COG0731	radical SAM domain protein
HR50_RS03860	COG0659	secondary active sulfate transmembrane transporter activity
HR50_RS03865	COG1592	Rubrerythrin
HR50_RS03870	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HR50_RS03890	COG0427	acetyl-CoA hydrolase
HR50_RS03900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HR50_RS03910	COG3250	beta-galactosidase activity
HR50_RS04010	COG2177	Part of the ABC transporter FtsEX involved in
HR50_RS04020	COG1968	undecaprenyl-diphosphatase activity
HR50_RS04025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HR50_RS04030	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HR50_RS04035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HR50_RS04045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HR50_RS04050	COG1611	Belongs to the LOG family
HR50_RS04065	COG0594	ribonuclease P activity
HR50_RS04070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HR50_RS04085	COG0823	Involved in the tonB-independent uptake of proteins
HR50_RS04085	COG1506	peptidase
HR50_RS04085	COG4946	Tricorn protease homolog
HR50_RS04095	COG3119	arylsulfatase activity
HR50_RS04100	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HR50_RS04105	COG1028	Short-chain dehydrogenase reductase Sdr
HR50_RS04115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HR50_RS04155	COG1121	(ABC) transporter
HR50_RS04165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HR50_RS04165	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HR50_RS04180	COG0151	Belongs to the GarS family
HR50_RS04185	COG1506	peptidase
HR50_RS04185	COG0823	Involved in the tonB-independent uptake of proteins
HR50_RS04190	COG0116	Belongs to the methyltransferase superfamily
HR50_RS04195	COG1045	serine acetyltransferase
HR50_RS04200	COG3275	phosphorelay sensor kinase activity
HR50_RS04205	COG3279	Response regulator of the LytR AlgR family
HR50_RS04215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HR50_RS04215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HR50_RS04235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HR50_RS04240	COG1694	Mazg nucleotide pyrophosphohydrolase
HR50_RS04250	COG0322	excinuclease ABC activity
HR50_RS04255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HR50_RS04260	COG0445	tRNA wobble uridine modification
HR50_RS04290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HR50_RS04325	COG2715	membrane protein required for spore maturation
HR50_RS04335	COG2255	four-way junction helicase activity
HR50_RS04350	COG3591	Belongs to the peptidase S1B family
HR50_RS04365	COG0513	Belongs to the DEAD box helicase family
HR50_RS04375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HR50_RS04400	COG0612	Peptidase, M16
HR50_RS04415	COG1312	Catalyzes the dehydration of D-mannonate
HR50_RS04420	COG1028	Short-chain dehydrogenase reductase Sdr
HR50_RS04430	COG0681	Belongs to the peptidase S26 family
HR50_RS04435	COG0681	Belongs to the peptidase S26 family
HR50_RS04440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HR50_RS04470	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HR50_RS04485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS04490	COG3250	beta-galactosidase activity
HR50_RS04520	COG0561	phosphatase activity
HR50_RS04565	COG0745	RESPONSE REGULATOR receiver
HR50_RS04570	COG5002	protein histidine kinase activity
HR50_RS04575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HR50_RS04590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HR50_RS04605	COG0205	6-phosphofructokinase activity
HR50_RS04610	COG0571	ribonuclease III activity
HR50_RS04615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HR50_RS04620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HR50_RS04625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HR50_RS04630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HR50_RS04645	COG1442	glycosyl transferase family 8
HR50_RS04655	COG1215	transferase activity, transferring glycosyl groups
HR50_RS04660	COG1442	glycosyl transferase family 8
HR50_RS04660	COG1216	Glycosyl transferase, family 2
HR50_RS04665	COG1132	(ABC) transporter
HR50_RS04675	COG3341	Caulimovirus viroplasmin
HR50_RS04675	COG0328	RNA-DNA hybrid ribonuclease activity
HR50_RS04700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HR50_RS04735	COG1166	arginine decarboxylase activity
HR50_RS04740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HR50_RS04810	COG1454	alcohol dehydrogenase
HR50_RS04815	COG0235	Class ii aldolase
HR50_RS04820	COG1070	Carbohydrate kinase
HR50_RS04825	COG0738	Major facilitator superfamily
HR50_RS04845	COG0779	Required for maturation of 30S ribosomal subunits
HR50_RS04850	COG0195	Participates in both transcription termination and antitermination
HR50_RS04855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HR50_RS04865	COG0719	Fe-S assembly protein
HR50_RS04875	COG0396	ATPase activity
HR50_RS04880	COG0719	Fe-S assembly protein
HR50_RS04885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HR50_RS04890	COG0393	Putative heavy-metal-binding
HR50_RS04895	COG3345	alpha-galactosidase
HR50_RS04905	COG1629	transport
HR50_RS04930	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HR50_RS04940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HR50_RS04955	COG3437	response regulator, receiver
HR50_RS04955	COG4999	Histidine kinase
HR50_RS04955	COG3850	Histidine kinase
HR50_RS04955	COG2205	protein histidine kinase activity
HR50_RS04975	COG0187	DNA topoisomerase II activity
HR50_RS04980	COG0268	Binds directly to 16S ribosomal RNA
HR50_RS04995	COG1381	Involved in DNA repair and RecF pathway recombination
HR50_RS05000	COG1610	YqeY-like protein
HR50_RS05005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HR50_RS05020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HR50_RS05025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HR50_RS05030	COG0772	Belongs to the SEDS family
HR50_RS05035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HR50_RS05040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HR50_RS05045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HR50_RS05065	COG2001	Belongs to the MraZ family
HR50_RS05085	COG4771	TonB-dependent receptor
HR50_RS05115	COG0756	dUTP diphosphatase activity
HR50_RS05130	COG4942	peptidase
HR50_RS05135	COG3292	Two component regulator propeller
HR50_RS05135	COG2205	protein histidine kinase activity
HR50_RS05135	COG0745	RESPONSE REGULATOR receiver
HR50_RS05140	COG3940	Belongs to the glycosyl hydrolase 43 family
HR50_RS05155	COG3250	beta-galactosidase activity
HR50_RS05170	COG3940	Belongs to the glycosyl hydrolase 43 family
HR50_RS05190	COG0383	alpha-mannosidase activity
HR50_RS05190	COG0383	alpha-mannosidase activity
HR50_RS05195	COG1629	transport
HR50_RS05195	COG4206	TonB-dependent receptor
HR50_RS05215	COG3507	Belongs to the glycosyl hydrolase 43 family
HR50_RS05250	COG3537	Alpha-1,2-mannosidase
HR50_RS05260	COG2017	converts alpha-aldose to the beta-anomer
HR50_RS05350	COG3408	Glycogen debranching enzyme
HR50_RS05355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HR50_RS05360	COG1022	Amp-dependent synthetase and ligase
HR50_RS05375	COG2954	triphosphatase activity
HR50_RS05395	COG3250	beta-galactosidase activity
HR50_RS05400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS05410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HR50_RS05430	COG1629	transport
HR50_RS05430	COG4206	TonB-dependent receptor
HR50_RS05435	COG0745	RESPONSE REGULATOR receiver
HR50_RS05435	COG2205	protein histidine kinase activity
HR50_RS05435	COG3292	Two component regulator propeller
HR50_RS05440	COG2205	protein histidine kinase activity
HR50_RS05440	COG3292	Two component regulator propeller
HR50_RS05440	COG0745	RESPONSE REGULATOR receiver
HR50_RS05465	COG4771	TonB-dependent receptor
HR50_RS05535	COG4771	TonB-dependent receptor
HR50_RS05560	COG0423	glycine-tRNA ligase activity
HR50_RS05565	COG0545	Peptidyl-prolyl cis-trans isomerase
HR50_RS05610	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HR50_RS05640	COG4771	TonB-dependent receptor
HR50_RS05645	COG3292	Two component regulator propeller
HR50_RS05645	COG3292	Two component regulator propeller
HR50_RS05645	COG0745	RESPONSE REGULATOR receiver
HR50_RS05645	COG2205	protein histidine kinase activity
HR50_RS05645	COG2205	protein histidine kinase activity
HR50_RS05645	COG0745	RESPONSE REGULATOR receiver
HR50_RS05655	COG3005	denitrification pathway
HR50_RS05660	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HR50_RS05670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HR50_RS05690	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HR50_RS05710	COG3876	Protein conserved in bacteria
HR50_RS05745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HR50_RS05750	COG3876	Protein conserved in bacteria
HR50_RS05755	COG0702	epimerase
HR50_RS05760	COG4206	TonB-dependent receptor
HR50_RS05760	COG1629	transport
HR50_RS05780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HR50_RS05785	COG0475	glutathione-regulated potassium exporter activity
HR50_RS05785	COG0589	response to stress
HR50_RS05790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HR50_RS05795	COG1136	(ABC) transporter
HR50_RS05805	COG0733	neurotransmitter:sodium symporter activity
HR50_RS05815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HR50_RS05830	COG0076	glutamate decarboxylase activity
HR50_RS05835	COG2066	Belongs to the glutaminase family
HR50_RS05845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HR50_RS05850	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HR50_RS05940	COG1346	cytolysis
HR50_RS05965	COG0280	phosphate acetyltransferase
HR50_RS05970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HR50_RS05975	COG1785	Belongs to the alkaline phosphatase family
HR50_RS05980	COG2151	metal-sulfur cluster biosynthetic enzyme
HR50_RS05985	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HR50_RS05990	COG2003	Belongs to the UPF0758 family
HR50_RS05995	COG1216	Glycosyl transferase, family 2
HR50_RS05995	COG0463	Glycosyl transferase, family 2
HR50_RS06010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HR50_RS06015	COG0515	serine threonine protein kinase
HR50_RS06015	COG2815	serine threonine protein kinase
HR50_RS06020	COG0564	pseudouridine synthase activity
HR50_RS06065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HR50_RS06070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HR50_RS06080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HR50_RS06100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HR50_RS06110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HR50_RS06110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HR50_RS06115	COG2890	protein-(glutamine-N5) methyltransferase activity
HR50_RS06120	COG2137	regulation of response to DNA damage stimulus
HR50_RS06125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HR50_RS06135	COG0165	Argininosuccinate lyase
HR50_RS06160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HR50_RS06165	COG1917	Cupin 2, conserved barrel domain protein
HR50_RS06165	COG1396	sequence-specific DNA binding
HR50_RS06170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HR50_RS06175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HR50_RS06185	COG0137	argininosuccinate synthase activity
HR50_RS06210	COG0784	Response regulator, receiver
HR50_RS06210	COG2205	protein histidine kinase activity
HR50_RS06215	COG0531	amino acid
HR50_RS06225	COG0039	L-malate dehydrogenase activity
HR50_RS06230	COG2996	Protein conserved in bacteria
HR50_RS06265	COG1538	Outer membrane efflux protein
HR50_RS06275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS06355	COG4974	Belongs to the 'phage' integrase family
HR50_RS06360	COG4974	Belongs to the 'phage' integrase family
HR50_RS06375	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HR50_RS06400	COG1629	transport
HR50_RS06430	COG1136	(ABC) transporter
HR50_RS06430	COG0577	efflux transmembrane transporter activity
HR50_RS06435	COG1136	(ABC) transporter
HR50_RS06435	COG0577	efflux transmembrane transporter activity
HR50_RS06440	COG1136	(ABC) transporter
HR50_RS06445	COG1940	carbohydrate kinase activity
HR50_RS06450	COG0335	large ribosomal subunit rRNA binding
HR50_RS06455	COG0737	Belongs to the 5'-nucleotidase family
HR50_RS06460	COG0737	Belongs to the 5'-nucleotidase family
HR50_RS06465	COG1472	Belongs to the glycosyl hydrolase 3 family
HR50_RS06470	COG1472	Belongs to the glycosyl hydrolase 3 family
HR50_RS06475	COG1629	transport
HR50_RS06475	COG4206	TonB-dependent receptor
HR50_RS06485	COG3119	arylsulfatase activity
HR50_RS06510	COG0446	pyridine nucleotide-disulphide oxidoreductase
HR50_RS06520	COG2204	response regulator
HR50_RS06530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HR50_RS06550	COG2205	protein histidine kinase activity
HR50_RS06555	COG5002	protein histidine kinase activity
HR50_RS06570	COG4771	TonB-dependent receptor
HR50_RS06615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HR50_RS06615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HR50_RS06620	COG0436	Aminotransferase
HR50_RS06625	COG3250	beta-galactosidase activity
HR50_RS06635	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HR50_RS06640	COG0826	peptidase U32
HR50_RS06650	COG4771	TonB-dependent receptor
HR50_RS06655	COG2197	response regulator
HR50_RS06660	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HR50_RS06670	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HR50_RS06680	COG0252	asparaginase activity
HR50_RS06685	COG0527	aspartate kinase activity
HR50_RS06685	COG0460	homoserine dehydrogenase
HR50_RS06690	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HR50_RS06695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HR50_RS06755	COG1629	transport
HR50_RS06755	COG4206	TonB-dependent receptor
HR50_RS06760	COG0702	epimerase
HR50_RS06765	COG3250	beta-galactosidase activity
HR50_RS06775	COG3507	Belongs to the glycosyl hydrolase 43 family
HR50_RS06790	COG4771	TonB-dependent receptor
HR50_RS06815	COG0628	permease
HR50_RS06830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HR50_RS06845	COG2095	MarC family integral membrane protein
HR50_RS06855	COG4206	TonB-dependent receptor
HR50_RS06855	COG1629	transport
HR50_RS06865	COG4974	Belongs to the 'phage' integrase family
HR50_RS06870	COG1629	transport
HR50_RS06880	COG4206	TonB-dependent receptor
HR50_RS06880	COG1629	transport
HR50_RS06890	COG4771	TonB-dependent receptor
HR50_RS06895	COG0702	epimerase
HR50_RS06900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HR50_RS06920	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HR50_RS06920	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HR50_RS06935	COG0531	amino acid
HR50_RS06950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HR50_RS06955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS06960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS07000	COG1162	GTPase activity
HR50_RS07005	COG0233	cytoplasmic translational termination
HR50_RS07025	COG0443	Heat shock 70 kDa protein
HR50_RS07050	COG0528	UMP kinase activity
HR50_RS07055	COG0534	Mate efflux family protein
HR50_RS07090	COG0792	nuclease activity
HR50_RS07115	COG1183	phosphatidylcholine synthase activity
HR50_RS07120	COG0688	phosphatidylethanolamine metabolic process
HR50_RS07130	COG3118	belongs to the thioredoxin family
HR50_RS07170	COG0714	Associated with various cellular activities
HR50_RS07185	COG0802	atpase or kinase
HR50_RS07190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HR50_RS07200	COG2234	aminopeptidase activity
HR50_RS07225	COG1629	transport
HR50_RS07245	COG3250	beta-galactosidase activity
HR50_RS07250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HR50_RS07260	COG2205	protein histidine kinase activity
HR50_RS07260	COG0784	Response regulator, receiver
HR50_RS07275	COG1629	transport
HR50_RS07275	COG4206	TonB-dependent receptor
HR50_RS07290	COG1566	PFAM secretion protein HlyD family protein
HR50_RS07315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HR50_RS07330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HR50_RS07335	COG0742	ribosomal rna small subunit methyltransferase
HR50_RS07360	COG4771	TonB-dependent receptor
HR50_RS07370	COG3537	Alpha-1,2-mannosidase
HR50_RS07385	COG3537	Alpha-1,2-mannosidase
HR50_RS07395	COG2814	Major facilitator Superfamily
HR50_RS07405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HR50_RS07410	COG0739	heme binding
HR50_RS07420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HR50_RS07425	COG3942	CHAP domain
HR50_RS07425	COG1388	LysM domain
HR50_RS07435	COG1475	DNA binding
HR50_RS07440	COG1192	Involved in chromosome partitioning
HR50_RS07450	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HR50_RS07455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HR50_RS07465	COG4589	Belongs to the CDS family
HR50_RS07470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HR50_RS07475	COG0799	negative regulation of ribosome biogenesis
HR50_RS07490	COG2239	Acts as a magnesium transporter
HR50_RS07495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HR50_RS07505	COG2195	Cleaves the N-terminal amino acid of tripeptides
HR50_RS07570	COG0668	transmembrane transport
HR50_RS07575	COG2207	Transcriptional regulator
HR50_RS07575	COG0662	Cupin 2, conserved barrel domain protein
HR50_RS07635	COG2244	polysaccharide biosynthetic process
HR50_RS07690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HR50_RS07700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HR50_RS07715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HR50_RS07725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HR50_RS07745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR50_RS07750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HR50_RS07775	COG0667	Aldo Keto reductase
HR50_RS07780	COG1472	Belongs to the glycosyl hydrolase 3 family
HR50_RS07785	COG4771	TonB-dependent receptor
HR50_RS07790	COG0702	epimerase
HR50_RS07835	COG5012	cobalamin binding
HR50_RS07850	COG4124	Belongs to the glycosyl hydrolase 26 family
HR50_RS07855	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HR50_RS07860	COG2211	Major facilitator Superfamily
HR50_RS07865	COG2942	2-epimerase
HR50_RS07915	COG2205	protein histidine kinase activity
HR50_RS07915	COG0784	Response regulator, receiver
HR50_RS07915	COG5002	protein histidine kinase activity
HR50_RS07925	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HR50_RS07930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HR50_RS07935	COG0713	ATP synthesis coupled electron transport
HR50_RS07940	COG0839	Belongs to the complex I subunit 6 family
HR50_RS07950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HR50_RS07955	COG0649	NAD binding
HR50_RS07955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HR50_RS07960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HR50_RS07965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HR50_RS07975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HR50_RS07980	COG0569	domain protein
HR50_RS07985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HR50_RS07995	COG1073	alpha beta
HR50_RS08005	COG0546	phosphoglycolate phosphatase activity
HR50_RS08010	COG3119	arylsulfatase activity
HR50_RS08025	COG3119	arylsulfatase activity
HR50_RS08045	COG1629	transport
HR50_RS08045	COG4206	TonB-dependent receptor
HR50_RS08050	COG3292	Two component regulator propeller
HR50_RS08050	COG2205	protein histidine kinase activity
HR50_RS08050	COG0745	RESPONSE REGULATOR receiver
HR50_RS08055	COG2271	Major facilitator Superfamily
HR50_RS08080	COG0805	protein transport
HR50_RS08085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HR50_RS08090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HR50_RS08125	COG4771	TonB-dependent receptor
HR50_RS08155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HR50_RS08160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HR50_RS08160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HR50_RS08165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HR50_RS08170	COG1078	dGTPase activity
HR50_RS08175	COG0284	orotidine-5'-phosphate decarboxylase activity
HR50_RS08180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HR50_RS08185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HR50_RS08200	COG1704	LemA family
HR50_RS08215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HR50_RS08220	COG2226	methyltransferase
HR50_RS08225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HR50_RS08230	COG1702	phosphate starvation-inducible protein PhoH
HR50_RS08240	COG2268	Band 7 protein
HR50_RS08250	COG5434	Belongs to the glycosyl hydrolase 28 family
HR50_RS08260	COG0101	tRNA pseudouridine synthase activity
HR50_RS08280	COG3250	beta-galactosidase activity
HR50_RS08285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HR50_RS08310	COG0457	Tetratricopeptide repeat
HR50_RS08315	COG0477	Major facilitator Superfamily
HR50_RS08315	COG2814	Major facilitator Superfamily
HR50_RS08340	COG0561	phosphatase activity
HR50_RS08345	COG1629	transport
HR50_RS08345	COG4206	TonB-dependent receptor
HR50_RS08355	COG4771	TonB-dependent receptor
HR50_RS08370	COG1629	transport
HR50_RS08370	COG4206	TonB-dependent receptor
HR50_RS08390	COG1629	transport
HR50_RS08390	COG4206	TonB-dependent receptor
HR50_RS08395	COG0702	epimerase
HR50_RS08400	COG0673	inositol 2-dehydrogenase activity
HR50_RS08445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HR50_RS08450	COG0793	Belongs to the peptidase S41A family
HR50_RS08455	COG2131	deaminase
HR50_RS08465	COG0339	signal peptide processing
HR50_RS08475	COG1970	mechanosensitive ion channel activity
HR50_RS08480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HR50_RS08480	COG0519	Catalyzes the synthesis of GMP from XMP
HR50_RS08490	COG1629	transport
HR50_RS08490	COG4206	TonB-dependent receptor
HR50_RS08500	COG1629	transport
HR50_RS08505	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HR50_RS08525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HR50_RS08555	COG1242	4 iron, 4 sulfur cluster binding
HR50_RS08565	COG0363	glucosamine-6-phosphate deaminase activity
HR50_RS08575	COG0009	L-threonylcarbamoyladenylate synthase
HR50_RS08585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HR50_RS08590	COG0561	phosphatase activity
HR50_RS08595	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HR50_RS08600	COG2873	o-acetylhomoserine
HR50_RS08655	COG0297	glycogen (starch) synthase activity
HR50_RS08660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HR50_RS08665	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HR50_RS08670	COG0543	2 iron, 2 sulfur cluster binding
HR50_RS08680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HR50_RS08690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HR50_RS08695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HR50_RS08715	COG0546	phosphoglycolate phosphatase activity
HR50_RS08720	COG0791	NLP P60 protein
HR50_RS08735	COG0612	Peptidase, M16
HR50_RS08740	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HR50_RS08745	COG1597	lipid kinase activity
HR50_RS08750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HR50_RS08760	COG1136	(ABC) transporter
HR50_RS08780	COG2211	Major facilitator Superfamily
HR50_RS08795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HR50_RS08810	COG1674	ftsk spoiiie
HR50_RS08820	COG0492	ferredoxin-NADP+ reductase activity
HR50_RS08825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS08870	COG1595	DNA-templated transcription, initiation
HR50_RS08885	COG3956	TIGRFAM MazG family protein
HR50_RS08895	COG0525	valine-tRNA ligase activity
HR50_RS08900	COG2205	protein histidine kinase activity
HR50_RS08900	COG0784	Response regulator, receiver
HR50_RS08925	COG4771	TonB-dependent receptor
HR50_RS08940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HR50_RS08955	COG4771	TonB-dependent receptor
HR50_RS08960	COG0702	epimerase
HR50_RS08965	COG3119	arylsulfatase activity
HR50_RS08970	COG3119	arylsulfatase activity
HR50_RS08990	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
HR50_RS09005	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HR50_RS09025	COG1253	flavin adenine dinucleotide binding
HR50_RS09035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HR50_RS09045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HR50_RS09085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HR50_RS09095	COG2226	methyltransferase
HR50_RS09145	COG0110	maltose O-acetyltransferase activity
HR50_RS09160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HR50_RS09180	COG1215	transferase activity, transferring glycosyl groups
HR50_RS09185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR50_RS09190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HR50_RS09205	COG4771	TonB-dependent receptor
HR50_RS09215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HR50_RS09220	COG0563	adenylate kinase activity
HR50_RS09225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HR50_RS09230	COG1496	oxidoreductase activity
HR50_RS09250	COG2706	6-phosphogluconolactonase activity
HR50_RS09305	COG1288	antiporter activity
HR50_RS09340	COG0564	pseudouridine synthase activity
HR50_RS09355	COG1501	Belongs to the glycosyl hydrolase 31 family
HR50_RS09360	COG1028	Short-chain dehydrogenase reductase Sdr
HR50_RS09380	COG3550	peptidyl-serine autophosphorylation
HR50_RS09405	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HR50_RS09420	COG3645	SOS response
HR50_RS09445	COG0582	viral genome integration into host DNA
HR50_RS09475	COG1910	domain protein
HR50_RS09495	COG4974	Belongs to the 'phage' integrase family
HR50_RS09515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HR50_RS09530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HR50_RS09540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HR50_RS09545	COG0326	Molecular chaperone. Has ATPase activity
HR50_RS09580	COG4974	Belongs to the 'phage' integrase family
HR50_RS09595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HR50_RS09600	COG2205	protein histidine kinase activity
HR50_RS09600	COG0784	Response regulator, receiver
HR50_RS09605	COG2910	NAD(P)H-binding
HR50_RS09610	COG2176	DNA-directed DNA polymerase activity
HR50_RS09620	COG4864	UPF0365 protein
HR50_RS09635	COG0037	tRNA processing
HR50_RS09655	COG1477	protein flavinylation
HR50_RS09660	COG1971	Probably functions as a manganese efflux pump
HR50_RS09675	COG0463	Glycosyl transferase, family 2
HR50_RS09690	COG0148	phosphopyruvate hydratase activity
HR50_RS09700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HR50_RS09705	COG1082	Xylose isomerase domain protein TIM barrel
HR50_RS09730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HR50_RS09735	COG0193	aminoacyl-tRNA hydrolase activity
HR50_RS09740	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HR50_RS09750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HR50_RS09755	COG1862	Preprotein translocase
HR50_RS09780	COG0542	response to heat
HR50_RS09790	COG0583	DNA-binding transcription factor activity
HR50_RS09795	COG2855	membrane
HR50_RS09810	COG1595	DNA-templated transcription, initiation
HR50_RS09825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HR50_RS09845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR50_RS09870	COG0443	Heat shock 70 kDa protein
HR50_RS09965	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HR50_RS09970	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HR50_RS09975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HR50_RS09995	COG1501	Belongs to the glycosyl hydrolase 31 family
HR50_RS10030	COG4206	TonB-dependent receptor
HR50_RS10030	COG1629	transport
HR50_RS10040	COG1408	metallophosphoesterase
HR50_RS10045	COG1368	sulfuric ester hydrolase activity
HR50_RS10055	COG3634	alkyl hydroperoxide reductase activity
HR50_RS10095	COG1760	l-serine dehydratase
HR50_RS10100	COG0598	Magnesium transport protein CorA
HR50_RS10105	COG1193	negative regulation of DNA recombination
HR50_RS10145	COG1063	alcohol dehydrogenase
HR50_RS10160	COG3119	arylsulfatase activity
HR50_RS10170	COG2855	membrane
HR50_RS10175	COG2217	Heavy metal translocating P-type atpase
HR50_RS10185	COG2885	chlorophyll binding
HR50_RS10210	COG3189	MarR family transcriptional regulator
HR50_RS10215	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HR50_RS10220	COG2195	Cleaves the N-terminal amino acid of tripeptides
HR50_RS10225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HR50_RS10245	COG4651	solute:proton antiporter activity
HR50_RS10245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HR50_RS10250	COG1280	lysine exporter protein (LysE YggA)
HR50_RS10265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HR50_RS10280	COG0561	phosphatase activity
HR50_RS10285	COG1169	isochorismate synthase
HR50_RS10290	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HR50_RS10305	COG4948	Mandelate Racemase Muconate Lactonizing
HR50_RS10320	COG1082	Xylose isomerase domain protein TIM barrel
HR50_RS10335	COG4771	TonB-dependent receptor
HR50_RS10365	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HR50_RS10370	COG0783	Belongs to the Dps family
HR50_RS10375	COG0583	DNA-binding transcription factor activity
HR50_RS10395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HR50_RS10450	COG4804	nuclease activity
HR50_RS10495	COG1253	flavin adenine dinucleotide binding
HR50_RS10500	COG0501	Belongs to the peptidase M48B family
HR50_RS10530	COG2873	o-acetylhomoserine
HR50_RS10535	COG0482	sulfurtransferase activity
HR50_RS10540	COG2197	response regulator
HR50_RS10550	COG1757	Na H antiporter
HR50_RS10565	COG2814	Major facilitator Superfamily
HR50_RS10570	COG4953	penicillin-binding protein 1C
HR50_RS10575	COG2373	Large extracellular alpha-helical protein
HR50_RS10585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HR50_RS10585	COG1918	ferrous iron import across plasma membrane
HR50_RS10690	COG1045	serine acetyltransferase
HR50_RS10695	COG0438	transferase activity, transferring glycosyl groups
HR50_RS10705	COG0424	maF-like protein
HR50_RS10710	COG1215	transferase activity, transferring glycosyl groups
HR50_RS10715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HR50_RS10720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HR50_RS10730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR50_RS10735	COG0490	domain, Protein
HR50_RS10735	COG0471	metal ion transport
HR50_RS10750	COG0346	lactoylglutathione lyase activity
HR50_RS10765	COG0259	pyridoxamine-phosphate oxidase activity
HR50_RS10770	COG1741	Belongs to the pirin family
HR50_RS10790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HR50_RS10820	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HR50_RS10830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HR50_RS10845	COG1595	DNA-templated transcription, initiation
HR50_RS10870	COG0686	Belongs to the AlaDH PNT family
HR50_RS10885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HR50_RS10905	COG0488	(ABC) transporter
HR50_RS10910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HR50_RS10915	COG3059	membrane
HR50_RS10920	COG2207	Transcriptional regulator
HR50_RS10920	COG1917	Cupin 2, conserved barrel domain protein
HR50_RS10925	COG0295	cytidine deaminase activity
HR50_RS10930	COG1388	LysM domain
HR50_RS10930	COG1705	Flagellar rod assembly protein muramidase FlgJ
HR50_RS10945	COG0577	efflux transmembrane transporter activity
HR50_RS10950	COG0577	efflux transmembrane transporter activity
HR50_RS10955	COG0577	efflux transmembrane transporter activity
HR50_RS10965	COG1136	(ABC) transporter
HR50_RS10965	COG0577	efflux transmembrane transporter activity
HR50_RS10980	COG1136	(ABC) transporter
HR50_RS10985	COG0577	efflux transmembrane transporter activity
HR50_RS10985	COG1136	(ABC) transporter
HR50_RS10995	COG1136	(ABC) transporter
HR50_RS11015	COG2205	protein histidine kinase activity
HR50_RS11015	COG0784	Response regulator, receiver
HR50_RS11030	COG2204	response regulator
HR50_RS11105	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HR50_RS11130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HR50_RS11150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HR50_RS11155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HR50_RS11165	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HR50_RS11170	COG1442	glycosyl transferase family 8
HR50_RS11170	COG1216	Glycosyl transferase, family 2
HR50_RS11180	COG1086	Polysaccharide biosynthesis protein
HR50_RS11190	COG1091	dTDP-4-dehydrorhamnose reductase activity
HR50_RS11200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR50_RS11205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HR50_RS11225	COG3119	arylsulfatase activity
HR50_RS11230	COG0629	single-stranded DNA binding
HR50_RS11295	COG4206	TonB-dependent receptor
HR50_RS11320	COG5002	protein histidine kinase activity
HR50_RS11325	COG0745	RESPONSE REGULATOR receiver
HR50_RS11355	COG0488	(ABC) transporter
HR50_RS11370	COG5492	domain, Protein
HR50_RS11380	COG0436	Aminotransferase
HR50_RS11385	COG4591	ABC-type transport system involved in lipoprotein release permease component
HR50_RS11390	COG1215	transferase activity, transferring glycosyl groups
HR50_RS11395	COG0628	permease
HR50_RS11400	COG3852	Histidine kinase
HR50_RS11415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS11420	COG0577	efflux transmembrane transporter activity
HR50_RS11420	COG1136	(ABC) transporter
HR50_RS11425	COG0577	efflux transmembrane transporter activity
HR50_RS11430	COG1252	NADH dehydrogenase
HR50_RS11460	COG4771	TonB-dependent receptor
HR50_RS11470	COG1620	l-lactate permease
HR50_RS11475	COG3047	cAMP biosynthetic process
HR50_RS11475	COG2885	chlorophyll binding
HR50_RS11485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HR50_RS11490	COG0439	Biotin carboxylase
HR50_RS11495	COG0511	ligase activity, forming carbon-carbon bonds
HR50_RS11500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HR50_RS11545	COG0508	dehydrogenase complex catalyzes the overall conversion of
HR50_RS11550	COG0022	dehydrogenase e1 component
HR50_RS11555	COG0716	FMN binding
HR50_RS11560	COG2264	protein methyltransferase activity
HR50_RS11575	COG0590	tRNA wobble adenosine to inosine editing
HR50_RS11605	COG0673	inositol 2-dehydrogenase activity
HR50_RS11615	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HR50_RS11655	COG0698	ribose 5-phosphate isomerase
HR50_RS11660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HR50_RS11665	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HR50_RS11680	COG1482	cell wall glycoprotein biosynthetic process
HR50_RS11700	COG0513	Belongs to the DEAD box helicase family
HR50_RS11705	COG4221	oxidoreductase activity
HR50_RS11720	COG3250	beta-galactosidase activity
HR50_RS11730	COG0471	metal ion transport
HR50_RS11730	COG3273	potassium ion transport
HR50_RS11735	COG0529	Catalyzes the synthesis of activated sulfate
HR50_RS11740	COG0175	sulfate reduction
HR50_RS11745	COG2895	sulfate adenylyltransferase (ATP) activity
HR50_RS11785	COG4974	Belongs to the 'phage' integrase family
HR50_RS11885	COG0358	DNA primase activity
HR50_RS11995	COG0519	Catalyzes the synthesis of GMP from XMP
HR50_RS12020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HR50_RS12020	COG2205	protein histidine kinase activity
HR50_RS12020	COG2198	Histidine kinase
HR50_RS12020	COG0784	Response regulator, receiver
HR50_RS12040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HR50_RS12040	COG0551	DNA topoisomerase type I activity
HR50_RS12085	COG1204	response to ionizing radiation
HR50_RS12095	COG4974	Belongs to the 'phage' integrase family
HR50_RS12100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HR50_RS12105	COG0242	peptide deformylase activity
HR50_RS12120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HR50_RS12125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HR50_RS12130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HR50_RS12135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HR50_RS12145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HR50_RS12150	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HR50_RS12165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HR50_RS12215	COG1940	carbohydrate kinase activity
HR50_RS12220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HR50_RS12230	COG2271	Major facilitator Superfamily
HR50_RS12235	COG2731	YhcH YjgK YiaL family protein
HR50_RS12240	COG4771	TonB-dependent receptor
HR50_RS12245	COG0702	epimerase
HR50_RS12250	COG1629	transport
HR50_RS12255	COG0702	epimerase
HR50_RS12275	COG1629	transport
HR50_RS12280	COG0702	epimerase
HR50_RS12295	COG4771	TonB-dependent receptor
HR50_RS12300	COG0702	epimerase
HR50_RS12305	COG0702	epimerase
HR50_RS12310	COG4206	TonB-dependent receptor
HR50_RS12310	COG1629	transport
HR50_RS12315	COG4206	TonB-dependent receptor
HR50_RS12315	COG1629	transport
HR50_RS12335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS12355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS12365	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS12370	COG3537	Alpha-1,2-mannosidase
HR50_RS12375	COG3250	beta-galactosidase activity
HR50_RS12380	COG1629	transport
HR50_RS12380	COG4206	TonB-dependent receptor
HR50_RS12385	COG0702	epimerase
HR50_RS12390	COG0484	heat shock protein binding
HR50_RS12395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HR50_RS12400	COG0488	(ABC) transporter
HR50_RS12405	COG1595	DNA-templated transcription, initiation
HR50_RS12530	COG2885	chlorophyll binding
HR50_RS12645	COG2183	response to ionizing radiation
HR50_RS12655	COG0737	Belongs to the 5'-nucleotidase family
HR50_RS12660	COG1956	GAF domain-containing protein
HR50_RS12670	COG4771	TonB-dependent receptor
HR50_RS12695	COG0534	Mate efflux family protein
HR50_RS12710	COG0534	Mate efflux family protein
HR50_RS12720	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HR50_RS12730	COG0318	PFAM AMP-dependent synthetase and ligase
HR50_RS12735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR50_RS12740	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HR50_RS12815	COG1086	Polysaccharide biosynthesis protein
HR50_RS12825	COG1091	dTDP-4-dehydrorhamnose reductase activity
HR50_RS12835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR50_RS12840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HR50_RS12875	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HR50_RS12880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HR50_RS12885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HR50_RS12890	COG0363	glucosamine-6-phosphate deaminase activity
HR50_RS12910	COG4413	Urea transporter
HR50_RS12950	COG3279	Response regulator of the LytR AlgR family
HR50_RS12960	COG1136	(ABC) transporter
HR50_RS12960	COG0577	efflux transmembrane transporter activity
HR50_RS12965	COG1136	(ABC) transporter
HR50_RS12970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS12995	COG3831	ATPase activity
HR50_RS12995	COG4884	unkown
HR50_RS13010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HR50_RS13020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HR50_RS13025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HR50_RS13030	COG3250	beta-galactosidase activity
HR50_RS13060	COG0501	Belongs to the peptidase M48B family
HR50_RS13065	COG1704	LemA family
HR50_RS13070	COG1595	DNA-templated transcription, initiation
HR50_RS13085	COG4206	TonB-dependent receptor
HR50_RS13085	COG1629	transport
HR50_RS13095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HR50_RS13100	COG2885	chlorophyll binding
HR50_RS13100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HR50_RS13110	COG0697	spore germination
HR50_RS13185	COG1846	Transcriptional regulator
HR50_RS13185	COG0456	acetyltransferase
HR50_RS13190	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HR50_RS13195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HR50_RS13200	COG2814	Major facilitator Superfamily
HR50_RS13205	COG4771	TonB-dependent receptor
HR50_RS13245	COG4771	TonB-dependent receptor
HR50_RS13415	COG0542	response to heat
HR50_RS13445	COG0156	8-amino-7-oxononanoate synthase activity
HR50_RS13670	COG4974	Belongs to the 'phage' integrase family
HR50_RS13735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HR50_RS13750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HR50_RS13790	COG1846	Transcriptional regulator
HR50_RS13845	COG0488	(ABC) transporter
HR50_RS13865	COG2205	protein histidine kinase activity
HR50_RS13865	COG0784	Response regulator, receiver
HR50_RS13885	COG0438	transferase activity, transferring glycosyl groups
HR50_RS13890	COG2244	polysaccharide biosynthetic process
HR50_RS13895	COG1216	Glycosyl transferase, family 2
HR50_RS13895	COG1442	glycosyl transferase family 8
HR50_RS13915	COG1215	transferase activity, transferring glycosyl groups
HR50_RS13945	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HR50_RS13950	COG1805	sodium ion transport
HR50_RS13955	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HR50_RS13980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HR50_RS13985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HR50_RS13995	COG0545	Peptidyl-prolyl cis-trans isomerase
HR50_RS14000	COG1739	Uncharacterized protein family UPF0029
HR50_RS14010	COG0778	Nitroreductase
HR50_RS14015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HR50_RS14015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HR50_RS14020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR50_RS14050	COG2217	Heavy metal translocating P-type atpase
HR50_RS14095	COG3852	Histidine kinase
HR50_RS14100	COG2204	response regulator
HR50_RS14120	COG1136	(ABC) transporter
HR50_RS14140	COG1755	Isoprenylcysteine carboxyl methyltransferase
HR50_RS14155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HR50_RS14170	COG1678	Uncharacterized ACR, COG1678
HR50_RS14195	COG0667	Aldo Keto reductase
HR50_RS14205	COG0656	L-ascorbic acid biosynthetic process
HR50_RS14215	COG0656	L-ascorbic acid biosynthetic process
HR50_RS14230	COG0534	Mate efflux family protein
HR50_RS14235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HR50_RS14250	COG1028	Short-chain dehydrogenase reductase Sdr
HR50_RS14290	COG1028	Short-chain dehydrogenase reductase Sdr
HR50_RS14295	COG0667	Aldo Keto reductase
HR50_RS14310	COG2311	Membrane
HR50_RS14315	COG0667	Aldo Keto reductase
HR50_RS14400	COG4771	TonB-dependent receptor
HR50_RS14435	COG1309	transcriptional regulator
HR50_RS14450	COG1132	(ABC) transporter
HR50_RS14460	COG2205	protein histidine kinase activity
HR50_RS14460	COG4999	Histidine kinase
HR50_RS14460	COG3437	response regulator, receiver
HR50_RS14460	COG3850	Histidine kinase
HR50_RS14475	COG1522	sequence-specific DNA binding
HR50_RS14495	COG3969	phosphoadenosine phosphosulfate
HR50_RS14500	COG1475	DNA binding
HR50_RS14550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR50_RS14555	COG0745	RESPONSE REGULATOR receiver
HR50_RS14570	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS14580	COG1629	transport
HR50_RS14580	COG4206	TonB-dependent receptor
HR50_RS14590	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HR50_RS14610	COG1022	Amp-dependent synthetase and ligase
HR50_RS14615	COG3263	regulation of cellular component size
HR50_RS14660	COG0577	efflux transmembrane transporter activity
HR50_RS14660	COG1136	(ABC) transporter
HR50_RS14670	COG1136	(ABC) transporter
HR50_RS14670	COG0577	efflux transmembrane transporter activity
HR50_RS14685	COG0534	Mate efflux family protein
HR50_RS14690	COG1011	Hydrolase
HR50_RS14695	COG0167	dihydroorotate dehydrogenase activity
HR50_RS14705	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HR50_RS14720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HR50_RS14740	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HR50_RS14750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HR50_RS14760	COG0356	it plays a direct role in the translocation of protons across the membrane
HR50_RS14765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HR50_RS14770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HR50_RS14775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HR50_RS14780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HR50_RS14785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HR50_RS14790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HR50_RS14795	COG3118	belongs to the thioredoxin family
HR50_RS14815	COG0745	RESPONSE REGULATOR receiver
HR50_RS14820	COG5002	protein histidine kinase activity
HR50_RS14860	COG1120	ATPase activity
HR50_RS14865	COG1091	dTDP-4-dehydrorhamnose reductase activity
HR50_RS14895	COG2205	protein histidine kinase activity
HR50_RS14895	COG2202	Pas domain
HR50_RS14900	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HR50_RS14910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HR50_RS14925	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HR50_RS14930	COG0540	Belongs to the ATCase OTCase family
HR50_RS14940	COG2431	L-lysine efflux transmembrane transporter activity
HR50_RS14970	COG2837	iron assimilation
HR50_RS14985	COG4206	TonB-dependent receptor
HR50_RS14985	COG1629	transport
HR50_RS15005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HR50_RS15025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HR50_RS15045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HR50_RS15050	COG2205	protein histidine kinase activity
HR50_RS15085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HR50_RS15090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HR50_RS15105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HR50_RS15115	COG0673	inositol 2-dehydrogenase activity
HR50_RS15130	COG2223	nitrite transmembrane transporter activity
HR50_RS15150	COG0671	phosphoesterase, PA-phosphatase related
HR50_RS15170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HR50_RS15175	COG0045	succinate-CoA ligase (ADP-forming) activity
HR50_RS15180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HR50_RS15185	COG0351	phosphomethylpyrimidine kinase
HR50_RS15195	COG1070	Carbohydrate kinase
HR50_RS15205	COG2814	Major facilitator Superfamily
HR50_RS15205	COG0477	Major facilitator Superfamily
HR50_RS15215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HR50_RS15215	COG3153	acetyltransferase
HR50_RS15220	COG0450	alkyl hydroperoxide reductase
HR50_RS15225	COG0724	RNA recognition motif
HR50_RS15230	COG1858	cytochrome C peroxidase
HR50_RS15235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HR50_RS15265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HR50_RS15275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HR50_RS15290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HR50_RS15355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HR50_RS15365	COG1904	glucuronate isomerase
HR50_RS15395	COG0513	Belongs to the DEAD box helicase family
HR50_RS15400	COG3830	Belongs to the UPF0237 family
HR50_RS15400	COG0560	Phosphoserine phosphatase
HR50_RS15420	COG0343	queuine tRNA-ribosyltransferase activity
HR50_RS15425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HR50_RS15465	COG2205	protein histidine kinase activity
HR50_RS15470	COG2204	response regulator
HR50_RS15650	COG1705	Flagellar rod assembly protein muramidase FlgJ
HR50_RS15715	COG0741	lytic transglycosylase activity
HR50_RS15715	COG1196	nuclear chromosome segregation
HR50_RS15715	COG0739	heme binding
HR50_RS15720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HR50_RS15805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HR50_RS15830	COG1192	Involved in chromosome partitioning
HR50_RS15875	COG1475	DNA binding
HR50_RS15880	COG2003	Belongs to the UPF0758 family
HR50_RS15950	COG1045	serine acetyltransferase
HR50_RS15955	COG2918	glutathione biosynthetic process
HR50_RS15955	COG0189	ligase activity
HR50_RS15960	COG0534	Mate efflux family protein
HR50_RS16105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HR50_RS16115	COG0577	efflux transmembrane transporter activity
HR50_RS16115	COG1136	(ABC) transporter
HR50_RS16120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR50_RS16195	COG0156	8-amino-7-oxononanoate synthase activity
HR50_RS16200	COG1597	lipid kinase activity
HR50_RS16230	COG1136	(ABC) transporter
HR50_RS16230	COG0577	efflux transmembrane transporter activity
HR50_RS16255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HR50_RS16285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HR50_RS16305	COG0543	2 iron, 2 sulfur cluster binding
HR50_RS16310	COG0167	dihydroorotate dehydrogenase activity
HR50_RS16320	COG0336	Belongs to the RNA methyltransferase TrmD family
HR50_RS16325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HR50_RS16330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HR50_RS16340	COG2315	Protein conserved in bacteria
HR50_RS16370	COG0326	Molecular chaperone. Has ATPase activity
HR50_RS16375	COG0542	response to heat
HR50_RS16420	COG2304	oxidoreductase activity
HR50_RS16435	COG0714	Associated with various cellular activities
HR50_RS16440	COG1652	LysM domain
HR50_RS16450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HR50_RS16455	COG0552	protein localization to endoplasmic reticulum
HR50_RS16465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HR50_RS16470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HR50_RS16480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HR50_RS16495	COG0442	prolyl-tRNA aminoacylation
HR50_RS16510	COG0793	Belongs to the peptidase S41A family
HR50_RS16510	COG4946	Tricorn protease homolog
HR50_RS16530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HR50_RS16535	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HR50_RS16545	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HR50_RS16555	COG1492	cobalamin metabolic process
HR50_RS16610	COG2096	Adenosyltransferase
HR50_RS16615	COG1797	cobyrinic acid a,c-diamide synthase activity
HR50_RS16630	COG2966	Psort location CytoplasmicMembrane, score
HR50_RS16645	COG4771	TonB-dependent receptor
HR50_RS16655	COG4774	siderophore transport
HR50_RS16665	COG1429	ligase activity, forming nitrogen-metal bonds
HR50_RS16700	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HR50_RS16835	COG0305	Participates in initiation and elongation during chromosome replication
HR50_RS16850	COG3023	N-Acetylmuramoyl-L-alanine amidase
HR50_RS16920	COG0352	thiamine-phosphate diphosphorylase activity
HR50_RS16925	COG2022	thiamine diphosphate biosynthetic process
HR50_RS16930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HR50_RS16950	COG0352	thiamine-phosphate diphosphorylase activity
HR50_RS16965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HR50_RS16965	COG0574	Belongs to the PEP-utilizing enzyme family
HR50_RS16970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HR50_RS16975	COG0564	pseudouridine synthase activity
HR50_RS16995	COG0024	Methionine aminopeptidase
HR50_RS17010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HR50_RS17020	COG0481	GTPase activity
HR50_RS17040	COG0708	Exodeoxyribonuclease III
HR50_RS17045	COG1914	H( )-stimulated, divalent metal cation uptake system
HR50_RS17060	COG0217	transcriptional regulatory protein
HR50_RS17065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HR50_RS17065	COG0072	phenylalanine-tRNA ligase activity
HR50_RS17070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HR50_RS17075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR50_RS17100	COG1216	Glycosyl transferase, family 2
HR50_RS17125	COG2089	acid synthase
HR50_RS17135	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HR50_RS17160	COG0305	Participates in initiation and elongation during chromosome replication
HR50_RS17180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HR50_RS17185	COG4657	Part of a membrane complex involved in electron transport
HR50_RS17190	COG4660	Part of a membrane complex involved in electron transport
HR50_RS17195	COG4659	FMN binding
HR50_RS17200	COG4658	electron transport chain
HR50_RS17205	COG4656	Part of a membrane complex involved in electron transport
HR50_RS17235	COG0504	CTP synthase activity
HR50_RS17240	COG0706	membrane insertase activity
HR50_RS17245	COG0534	Mate efflux family protein
HR50_RS17250	COG0823	Involved in the tonB-independent uptake of proteins
HR50_RS17250	COG1506	peptidase
HR50_RS17265	COG1695	Transcriptional regulator
HR50_RS17280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HR50_RS17290	COG1388	LysM domain
HR50_RS17290	COG3942	CHAP domain
HR50_RS17320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HR50_RS17330	COG0556	nucleotide-excision repair
HR50_RS17340	COG2949	membrane
HR50_RS17350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HR50_RS17360	COG2205	protein histidine kinase activity
HR50_RS17360	COG0784	Response regulator, receiver
HR50_RS17370	COG0842	Transport permease protein
HR50_RS17375	COG1131	(ABC) transporter
HR50_RS17405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HR50_RS17410	COG0505	Belongs to the CarA family
HR50_RS17420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HR50_RS17425	COG0367	asparagine synthase
HR50_RS17455	COG0436	Aminotransferase
HR50_RS17465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HR50_RS17475	COG1979	alcohol dehydrogenase
HR50_RS17495	COG0133	tryptophan synthase activity
HR50_RS17500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HR50_RS17505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HR50_RS17505	COG0512	Glutamine amidotransferase of anthranilate synthase
HR50_RS17515	COG0134	indole-3-glycerol-phosphate synthase activity
HR50_RS17520	COG0135	phosphoribosylanthranilate isomerase activity
HR50_RS17525	COG0159	tryptophan synthase activity
HR50_RS17535	COG0252	asparaginase activity
HR50_RS17550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HR50_RS17560	COG0110	maltose O-acetyltransferase activity
HR50_RS17565	COG2197	response regulator
HR50_RS17575	COG0138	bifunctional purine biosynthesis protein purh
HR50_RS17580	COG0716	FMN binding
HR50_RS17610	COG1858	cytochrome C peroxidase
HR50_RS17620	COG4771	TonB-dependent receptor
HR50_RS17635	COG2814	Major facilitator Superfamily
HR50_RS17640	COG1566	PFAM secretion protein HlyD family protein
HR50_RS17655	COG1230	cation diffusion facilitator family transporter
HR50_RS17675	COG4771	TonB-dependent receptor
HR50_RS17700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HR50_RS17705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HR50_RS17720	COG2966	Psort location CytoplasmicMembrane, score
HR50_RS17725	COG3610	response to peptide
HR50_RS17740	COG1609	Transcriptional regulator
HR50_RS17750	COG1733	regulation of RNA biosynthetic process
HR50_RS17760	COG2205	protein histidine kinase activity
HR50_RS17760	COG2198	Histidine kinase
HR50_RS17760	COG0784	Response regulator, receiver
HR50_RS17760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HR50_RS17785	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HR50_RS17790	COG1690	Belongs to the RtcB family
HR50_RS17840	COG0724	RNA recognition motif
HR50_RS17850	COG1177	transmembrane transport
HR50_RS17855	COG1176	ABC-type spermidine putrescine transport system, permease component I
HR50_RS17865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR50_RS17875	COG0058	SHG alpha-glucan phosphorylase activity
HR50_RS17885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HR50_RS17905	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HR50_RS17965	COG0745	RESPONSE REGULATOR receiver
HR50_RS17970	COG5002	protein histidine kinase activity
HR50_RS17995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HR50_RS18005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HR50_RS18015	COG4948	Mandelate Racemase Muconate Lactonizing
HR50_RS18030	COG1295	ribonuclease BN
HR50_RS18040	COG0778	Nitroreductase
HR50_RS18050	COG0704	Plays a role in the regulation of phosphate uptake
HR50_RS18055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HR50_RS18060	COG0581	inorganic phosphate transmembrane transporter activity
HR50_RS18065	COG0573	inorganic phosphate transmembrane transporter activity
HR50_RS18075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HR50_RS18100	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HR50_RS18145	COG3023	N-Acetylmuramoyl-L-alanine amidase
HR50_RS18205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HR50_RS18235	COG0438	transferase activity, transferring glycosyl groups
HR50_RS18265	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HR50_RS18315	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HR50_RS18355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HR50_RS18360	COG0167	dihydroorotate dehydrogenase activity
HR50_RS18430	COG5002	protein histidine kinase activity
HR50_RS18445	COG2172	sigma factor antagonist activity
HR50_RS18455	COG2208	phosphoserine phosphatase activity
HR50_RS18485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HR50_RS18505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HR50_RS18510	COG0497	DNA recombination
HR50_RS18520	COG2176	DNA-directed DNA polymerase activity
HR50_RS18520	COG5002	protein histidine kinase activity
HR50_RS18525	COG0592	DNA-directed DNA polymerase activity
HR50_RS18540	COG0321	lipoyl(octanoyl) transferase activity
HR50_RS18540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HR50_RS18555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR50_RS18565	COG0156	8-amino-7-oxononanoate synthase activity
HR50_RS18660	COG0019	diaminopimelate decarboxylase activity
HR50_RS18665	COG0527	aspartate kinase activity
HR50_RS18670	COG2884	Cell division ATP-binding protein ftsE
HR50_RS18675	COG0140	phosphoribosyl-ATP diphosphatase activity
HR50_RS18675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HR50_RS18685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HR50_RS18775	COG1472	Belongs to the glycosyl hydrolase 3 family
HR50_RS18780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HR50_RS18790	COG5012	cobalamin binding
HR50_RS18800	COG1472	Belongs to the glycosyl hydrolase 3 family
HR50_RS18805	COG0702	epimerase
HR50_RS18810	COG4771	TonB-dependent receptor
HR50_RS18830	COG0693	protein deglycase activity
HR50_RS18845	COG0494	nUDIX hydrolase
HR50_RS18850	COG1401	restriction endodeoxyribonuclease activity
HR50_RS18870	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HR50_RS18920	COG1917	Cupin 2, conserved barrel domain protein
HR50_RS18920	COG4977	sequence-specific DNA binding
HR50_RS18925	COG2814	Major facilitator Superfamily
HR50_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
HR50_RS18935	COG2207	Transcriptional regulator
HR50_RS18950	COG1090	epimerase
HR50_RS18980	COG0561	phosphatase activity
HR50_RS18985	COG4206	TonB-dependent receptor
HR50_RS18985	COG1629	transport
HR50_RS19035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HR50_RS19045	COG0363	glucosamine-6-phosphate deaminase activity
HR50_RS19095	COG1032	radical SAM domain protein
HR50_RS19100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HR50_RS19105	COG0463	Glycosyl transferase, family 2
HR50_RS19110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HR50_RS19120	COG0646	methionine synthase
HR50_RS19120	COG1410	methionine synthase
HR50_RS19185	COG1408	metallophosphoesterase
HR50_RS19190	COG1132	(ABC) transporter
HR50_RS19195	COG1132	(ABC) transporter
HR50_RS19210	COG0420	3'-5' exonuclease activity
HR50_RS19230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HR50_RS19235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS19245	COG0681	Belongs to the peptidase S26 family
HR50_RS19355	COG0641	radical SAM
HR50_RS19360	COG3591	Belongs to the peptidase S1B family
HR50_RS19365	COG3591	Belongs to the peptidase S1B family
HR50_RS19400	COG1773	rubredoxin
HR50_RS19400	COG1592	Rubrerythrin
HR50_RS19410	COG3152	Membrane
HR50_RS19415	COG0339	signal peptide processing
HR50_RS19420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HR50_RS19420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HR50_RS19430	COG1629	transport
HR50_RS19430	COG4206	TonB-dependent receptor
HR50_RS19445	COG0131	Imidazoleglycerol-phosphate dehydratase
HR50_RS19445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HR50_RS19455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HR50_RS19460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HR50_RS19470	COG1741	Belongs to the pirin family
HR50_RS19475	COG4232	protein-disulfide reductase activity
HR50_RS19485	COG0572	uridine kinase
HR50_RS19495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HR50_RS19505	COG1410	methionine synthase
HR50_RS19505	COG0646	methionine synthase
HR50_RS19510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HR50_RS19545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HR50_RS19575	COG2202	Pas domain
HR50_RS19575	COG2205	protein histidine kinase activity
HR50_RS19580	COG2205	protein histidine kinase activity
HR50_RS19580	COG2202	Pas domain
HR50_RS19585	COG0534	Mate efflux family protein
HR50_RS19590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HR50_RS19595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR50_RS19600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HR50_RS19605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR50_RS19665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HR50_RS19705	COG2195	Cleaves the N-terminal amino acid of tripeptides
HR50_RS19715	COG0668	transmembrane transport
HR50_RS19720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HR50_RS19730	COG3250	beta-galactosidase activity
HR50_RS19735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS19740	COG3119	arylsulfatase activity
HR50_RS19745	COG3119	arylsulfatase activity
HR50_RS19750	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS19755	COG2205	protein histidine kinase activity
HR50_RS19755	COG0745	RESPONSE REGULATOR receiver
HR50_RS19755	COG3292	Two component regulator propeller
HR50_RS19760	COG1830	Aldolase
HR50_RS19765	COG0588	phosphoglycerate mutase activity
HR50_RS19775	COG1119	ATPase activity
HR50_RS19780	COG3119	arylsulfatase activity
HR50_RS19785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS19795	COG1629	transport
HR50_RS19795	COG4206	TonB-dependent receptor
HR50_RS19805	COG1595	DNA-templated transcription, initiation
HR50_RS19810	COG1523	belongs to the glycosyl hydrolase 13 family
HR50_RS19815	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HR50_RS19840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HR50_RS19850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HR50_RS19855	COG0126	phosphoglycerate kinase activity
HR50_RS19870	COG2311	Membrane
HR50_RS19915	COG0424	maF-like protein
HR50_RS19920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HR50_RS19935	COG0778	Nitroreductase
HR50_RS19940	COG0288	reversible hydration of carbon dioxide
HR50_RS19955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HR50_RS19965	COG0511	ligase activity, forming carbon-carbon bonds
HR50_RS19965	COG5016	pyruvate
HR50_RS19970	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HR50_RS19985	COG0366	Alpha amylase catalytic
HR50_RS20005	COG0191	fructose-bisphosphate aldolase activity
HR50_RS20015	COG0254	rRNA binding
HR50_RS20040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HR50_RS20045	COG1629	transport
HR50_RS20045	COG4206	TonB-dependent receptor
HR50_RS20050	COG1609	Transcriptional regulator
HR50_RS20060	COG1554	hydrolase, family 65, central catalytic
HR50_RS20065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS20085	COG0047	phosphoribosylformylglycinamidine synthase activity
HR50_RS20085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HR50_RS20090	COG2205	protein histidine kinase activity
HR50_RS20090	COG3292	Two component regulator propeller
HR50_RS20090	COG0745	RESPONSE REGULATOR receiver
HR50_RS20105	COG1649	PFAM Uncharacterised BCR, COG1649
HR50_RS20125	COG1966	Carbon starvation protein
HR50_RS20135	COG1649	PFAM Uncharacterised BCR, COG1649
HR50_RS20140	COG0784	Response regulator, receiver
HR50_RS20140	COG2205	protein histidine kinase activity
HR50_RS20180	COG2113	Glycine betaine
HR50_RS20185	COG4176	ABC-type proline glycine betaine transport system permease component
HR50_RS20205	COG2205	protein histidine kinase activity
HR50_RS20205	COG3292	Two component regulator propeller
HR50_RS20205	COG0745	RESPONSE REGULATOR receiver
HR50_RS20210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HR50_RS20210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HR50_RS20220	COG1621	beta-fructofuranosidase activity
HR50_RS20265	COG0738	Major facilitator superfamily
HR50_RS20280	COG1752	Esterase of the alpha-beta hydrolase superfamily
HR50_RS20285	COG0475	glutathione-regulated potassium exporter activity
HR50_RS20310	COG3015	lipoprotein NlpE involved in copper resistance
HR50_RS20330	COG4977	sequence-specific DNA binding
HR50_RS20330	COG1917	Cupin 2, conserved barrel domain protein
HR50_RS20365	COG4771	TonB-dependent receptor
HR50_RS20370	COG0702	epimerase
HR50_RS20385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HR50_RS20405	COG0484	heat shock protein binding
HR50_RS20410	COG2205	protein histidine kinase activity
HR50_RS20410	COG0784	Response regulator, receiver
HR50_RS20415	COG2194	sulfuric ester hydrolase activity
HR50_RS20465	COG0028	Belongs to the TPP enzyme family
HR50_RS20490	COG0459	protein refolding
HR50_RS20495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HR50_RS20535	COG2326	polyphosphate kinase activity
HR50_RS20580	COG3537	Alpha-1,2-mannosidase
HR50_RS20585	COG0823	Involved in the tonB-independent uptake of proteins
HR50_RS20585	COG1506	peptidase
HR50_RS20620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HR50_RS20665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HR50_RS20675	COG0671	phosphoesterase, PA-phosphatase related
HR50_RS20695	COG0702	epimerase
HR50_RS20700	COG1629	transport
HR50_RS20700	COG4206	TonB-dependent receptor
HR50_RS20730	COG0463	Glycosyl transferase, family 2
HR50_RS20745	COG0066	3-isopropylmalate dehydratase activity
HR50_RS20755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HR50_RS20760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HR50_RS20820	COG0616	signal peptide processing
HR50_RS20830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HR50_RS20835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HR50_RS20920	COG0546	phosphoglycolate phosphatase activity
HR50_RS20935	COG2207	Transcriptional regulator
HR50_RS20940	COG3292	Two component regulator propeller
HR50_RS20940	COG2205	protein histidine kinase activity
HR50_RS20940	COG0745	RESPONSE REGULATOR receiver
HR50_RS20945	COG4948	Mandelate Racemase Muconate Lactonizing
HR50_RS20965	COG0702	epimerase
HR50_RS20970	COG1629	transport
HR50_RS20970	COG4206	TonB-dependent receptor
HR50_RS21000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HR50_RS21005	COG1917	Cupin 2, conserved barrel domain protein
HR50_RS21005	COG2207	Transcriptional regulator
HR50_RS21030	COG3011	Protein conserved in bacteria
HR50_RS21040	COG1028	Short-chain dehydrogenase reductase Sdr
HR50_RS21105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HR50_RS21120	COG4651	solute:proton antiporter activity
HR50_RS21120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HR50_RS21125	COG0439	Biotin carboxylase
HR50_RS21130	COG5016	pyruvate
HR50_RS21130	COG0511	ligase activity, forming carbon-carbon bonds
HR50_RS21135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HR50_RS21140	COG1335	isochorismatase
HR50_RS21175	COG0517	IMP dehydrogenase activity
HR50_RS21175	COG0516	GMP reductase activity
HR50_RS21190	COG2207	Transcriptional regulator
HR50_RS21200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR50_RS21215	COG2873	o-acetylhomoserine
HR50_RS21305	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HR50_RS21315	COG1388	LysM domain
HR50_RS21315	COG0741	lytic transglycosylase activity
HR50_RS21320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HR50_RS21325	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HR50_RS21325	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HR50_RS21335	COG1285	pathogenesis
HR50_RS21355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HR50_RS21355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HR50_RS21370	COG1115	amino acid carrier protein
HR50_RS21380	COG1509	lysine 2,3-aminomutase activity
HR50_RS21385	COG2233	PERMEase
HR50_RS21405	COG1393	Belongs to the ArsC family
HR50_RS21415	COG1629	transport
HR50_RS21415	COG4206	TonB-dependent receptor
HR50_RS21430	COG4589	Belongs to the CDS family
HR50_RS21440	COG2304	oxidoreductase activity
HR50_RS21450	COG0351	phosphomethylpyrimidine kinase
HR50_RS21460	COG1139	Iron-sulfur cluster binding protein
HR50_RS21465	COG0247	lactate metabolic process
HR50_RS21470	COG0602	queuosine metabolic process
HR50_RS21480	COG2832	Protein of unknown function (DUF454)
HR50_RS21485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HR50_RS21500	COG3142	Participates in the control of copper homeostasis
HR50_RS21505	COG1418	mRNA catabolic process
HR50_RS21530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HR50_RS21550	COG4771	TonB-dependent receptor
HR50_RS21695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HR50_RS21695	COG0617	tRNA 3'-terminal CCA addition
HR50_RS21695	COG0517	IMP dehydrogenase activity
HR50_RS21705	COG1629	transport
HR50_RS21705	COG4206	TonB-dependent receptor
HR50_RS21720	COG0612	Peptidase, M16
HR50_RS21730	COG1278	Cold shock
HR50_RS21780	COG0438	transferase activity, transferring glycosyl groups
HR50_RS21785	COG1216	Glycosyl transferase, family 2
HR50_RS21790	COG0463	Glycosyl transferase, family 2
HR50_RS21800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR50_RS21815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HR50_RS21825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HR50_RS21875	COG0776	regulation of translation
HR50_RS21880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HR50_RS21915	COG0632	four-way junction helicase activity
HR50_RS21920	COG0673	inositol 2-dehydrogenase activity
HR50_RS21925	COG1272	protein, Hemolysin III
HR50_RS21930	COG1328	CTP reductase activity
HR50_RS21940	COG2814	Major facilitator Superfamily
HR50_RS21950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HR50_RS21960	COG0750	zinc metalloprotease
HR50_RS21975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HR50_RS21980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HR50_RS21990	COG1214	PFAM Peptidase M22, glycoprotease
HR50_RS22015	COG0194	GDP metabolic process
HR50_RS22020	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HR50_RS22025	COG1408	metallophosphoesterase
HR50_RS22030	COG1575	Belongs to the MenA family. Type 1 subfamily
HR50_RS22035	COG1088	dTDP-glucose 4,6-dehydratase activity
HR50_RS22040	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HR50_RS22050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HR50_RS22060	COG2204	response regulator
HR50_RS22065	COG0488	(ABC) transporter
HR50_RS22145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HR50_RS22155	COG1522	sequence-specific DNA binding
HR50_RS22185	COG0811	peptide transport
HR50_RS22195	COG0084	hydrolase, TatD family'
HR50_RS22210	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HR50_RS22215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HR50_RS22220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HR50_RS22225	COG0205	6-phosphofructokinase activity
HR50_RS22245	COG0372	Belongs to the citrate synthase family
HR50_RS22250	COG0538	isocitrate dehydrogenase activity
HR50_RS22260	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HR50_RS22270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HR50_RS22295	COG0129	dihydroxy-acid dehydratase activity
HR50_RS22320	COG2885	chlorophyll binding
HR50_RS22340	COG3681	Belongs to the UPF0597 family
HR50_RS22375	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HR50_RS22385	COG0702	epimerase
HR50_RS22390	COG4771	TonB-dependent receptor
HR50_RS22405	COG0702	epimerase
HR50_RS22410	COG4206	TonB-dependent receptor
HR50_RS22410	COG1629	transport
HR50_RS22425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS22425	COG3291	Pkd domain containing protein
HR50_RS22435	COG4771	TonB-dependent receptor
HR50_RS22470	COG1012	belongs to the aldehyde dehydrogenase family
HR50_RS22490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HR50_RS22490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HR50_RS22495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HR50_RS22525	COG1752	Esterase of the alpha-beta hydrolase superfamily
HR50_RS22535	COG0534	Mate efflux family protein
HR50_RS22540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HR50_RS22545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HR50_RS22550	COG0166	Belongs to the GPI family
HR50_RS22560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HR50_RS22570	COG2502	aspartate--ammonia ligase
HR50_RS22575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HR50_RS22590	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HR50_RS22600	COG1472	Belongs to the glycosyl hydrolase 3 family
HR50_RS22615	COG0860	N-Acetylmuramoyl-L-alanine amidase
HR50_RS22715	COG2337	Toxic component of a toxin-antitoxin (TA) module