locus-tag	class	description
IA74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IA74_RS00020	COG1640	4-alpha-glucanotransferase
IA74_RS00030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IA74_RS00035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IA74_RS00060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IA74_RS00065	COG1022	Amp-dependent synthetase and ligase
IA74_RS00080	COG0359	binds to the 23S rRNA
IA74_RS00085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IA74_RS00090	COG0360	Binds together with S18 to 16S ribosomal RNA
IA74_RS00110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IA74_RS00120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IA74_RS00140	COG4771	TonB-dependent receptor
IA74_RS00190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IA74_RS00195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IA74_RS00200	COG0386	Belongs to the glutathione peroxidase family
IA74_RS00220	COG3275	phosphorelay sensor kinase activity
IA74_RS00225	COG3279	Response regulator of the LytR AlgR family
IA74_RS00235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IA74_RS00245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IA74_RS00260	COG3250	beta-galactosidase activity
IA74_RS00265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IA74_RS00275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IA74_RS00280	COG0658	competence protein
IA74_RS00285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IA74_RS00290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IA74_RS00300	COG0009	L-threonylcarbamoyladenylate synthase
IA74_RS00320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IA74_RS00325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IA74_RS00335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IA74_RS00340	COG0438	transferase activity, transferring glycosyl groups
IA74_RS00345	COG3475	LICD family
IA74_RS00370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IA74_RS00375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IA74_RS00380	COG1028	Short-chain dehydrogenase reductase Sdr
IA74_RS00395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IA74_RS00400	COG1086	Polysaccharide biosynthesis protein
IA74_RS00405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IA74_RS00420	COG4750	Nucleotidyl transferase
IA74_RS00460	COG2818	Glycosylase
IA74_RS00475	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IA74_RS00475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IA74_RS00480	COG0514	ATP-dependent DNA helicase (RecQ)
IA74_RS00495	COG0436	Aminotransferase
IA74_RS00500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IA74_RS00530	COG0358	DNA primase activity
IA74_RS00535	COG3119	arylsulfatase activity
IA74_RS00540	COG0702	epimerase
IA74_RS00545	COG1629	transport
IA74_RS00545	COG4206	TonB-dependent receptor
IA74_RS00560	COG0302	gtp cyclohydrolase
IA74_RS00570	COG0149	triose-phosphate isomerase activity
IA74_RS00585	COG0739	heme binding
IA74_RS00590	COG0105	UTP biosynthetic process
IA74_RS00595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IA74_RS00620	COG0811	peptide transport
IA74_RS00630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IA74_RS00675	COG1629	transport
IA74_RS00705	COG0823	Involved in the tonB-independent uptake of proteins
IA74_RS00705	COG1506	peptidase
IA74_RS00705	COG4946	Tricorn protease homolog
IA74_RS00710	COG0039	L-malate dehydrogenase activity
IA74_RS00760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA74_RS00775	COG4948	Mandelate Racemase Muconate Lactonizing
IA74_RS00800	COG3118	belongs to the thioredoxin family
IA74_RS00805	COG0489	protein tyrosine kinase activity
IA74_RS00820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IA74_RS00830	COG1570	exodeoxyribonuclease VII activity
IA74_RS00840	COG0482	sulfurtransferase activity
IA74_RS00860	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IA74_RS00865	COG0179	Fumarylacetoacetate (FAA) hydrolase
IA74_RS00870	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IA74_RS00880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IA74_RS00885	COG0052	Belongs to the universal ribosomal protein uS2 family
IA74_RS00890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IA74_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IA74_RS00910	COG0017	Asparaginyl-tRNA synthetase
IA74_RS00915	COG1187	pseudouridine synthase activity
IA74_RS00955	COG0110	maltose O-acetyltransferase activity
IA74_RS00960	COG3022	response to hydroperoxide
IA74_RS00965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS01025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IA74_RS01065	COG1216	Glycosyl transferase, family 2
IA74_RS01090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IA74_RS01110	COG0297	glycogen (starch) synthase activity
IA74_RS01130	COG2205	protein histidine kinase activity
IA74_RS01135	COG0745	RESPONSE REGULATOR receiver
IA74_RS01190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IA74_RS01205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IA74_RS01220	COG0516	GMP reductase activity
IA74_RS01220	COG0517	IMP dehydrogenase activity
IA74_RS01225	COG0514	ATP-dependent DNA helicase (RecQ)
IA74_RS01230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IA74_RS01240	COG0544	peptidyl-prolyl cis-trans isomerase activity
IA74_RS01245	COG0724	RNA recognition motif
IA74_RS01255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IA74_RS01260	COG1127	ABC transporter
IA74_RS01265	COG0745	RESPONSE REGULATOR receiver
IA74_RS01270	COG1160	GTP binding
IA74_RS01275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IA74_RS01280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IA74_RS01330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IA74_RS01335	COG0470	DNA polymerase III
IA74_RS01340	COG1774	PSP1 C-terminal conserved region
IA74_RS01350	COG0772	Belongs to the SEDS family
IA74_RS01365	COG1792	Involved in formation and maintenance of cell shape
IA74_RS01375	COG0138	bifunctional purine biosynthesis protein purh
IA74_RS01380	COG3590	peptidase
IA74_RS01385	COG0488	(ABC) transporter
IA74_RS01410	COG0784	Response regulator, receiver
IA74_RS01410	COG2205	protein histidine kinase activity
IA74_RS01415	COG0534	Mate efflux family protein
IA74_RS01420	COG0612	Peptidase, M16
IA74_RS01425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IA74_RS01440	COG0564	pseudouridine synthase activity
IA74_RS01480	COG1131	(ABC) transporter
IA74_RS01570	COG1696	Membrane protein involved in D-alanine export
IA74_RS01605	COG1309	transcriptional regulator
IA74_RS01610	COG2986	histidine ammonia-lyase
IA74_RS01620	COG1228	amidohydrolase
IA74_RS01630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IA74_RS01640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IA74_RS01655	COG0203	ribosomal protein L17
IA74_RS01660	COG0202	RNA polymerase activity
IA74_RS01665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IA74_RS01670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IA74_RS01675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IA74_RS01680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IA74_RS01685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IA74_RS01700	COG0200	Binds to the 23S rRNA
IA74_RS01705	COG1841	ribosomal large subunit assembly
IA74_RS01710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IA74_RS01715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IA74_RS01720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IA74_RS01725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IA74_RS01730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IA74_RS01735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IA74_RS01740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IA74_RS01745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IA74_RS01750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IA74_RS01755	COG0255	Belongs to the universal ribosomal protein uL29 family
IA74_RS01760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IA74_RS01765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IA74_RS01770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IA74_RS01775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IA74_RS01780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IA74_RS01785	COG0089	rRNA binding
IA74_RS01790	COG0088	Forms part of the polypeptide exit tunnel
IA74_RS01795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IA74_RS01800	COG0051	transcription antitermination factor activity, RNA binding
IA74_RS01805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IA74_RS01810	COG0049	tRNA binding
IA74_RS01815	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IA74_RS01845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IA74_RS01850	COG0085	RNA polymerase activity
IA74_RS01855	COG0222	ribosome binding
IA74_RS01860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IA74_RS01865	COG0081	regulation of translation
IA74_RS01870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IA74_RS01915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IA74_RS01920	COG4974	Belongs to the 'phage' integrase family
IA74_RS01925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IA74_RS01930	COG0006	proline dipeptidase activity
IA74_RS01935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IA74_RS01945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IA74_RS01950	COG1480	7TM receptor with intracellular HD hydrolase
IA74_RS01955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IA74_RS01965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IA74_RS01980	COG1027	Aspartate ammonia-lyase
IA74_RS01985	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IA74_RS01990	COG0252	asparaginase activity
IA74_RS02005	COG2096	Adenosyltransferase
IA74_RS02045	COG1629	transport
IA74_RS02075	COG2755	lipolytic protein G-D-S-L family
IA74_RS02075	COG0657	acetylesterase activity
IA74_RS02090	COG3279	Response regulator of the LytR AlgR family
IA74_RS02105	COG4771	TonB-dependent receptor
IA74_RS02125	COG2197	response regulator
IA74_RS02130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IA74_RS02135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IA74_RS02145	COG4974	Belongs to the 'phage' integrase family
IA74_RS02150	COG4804	nuclease activity
IA74_RS02175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IA74_RS02215	COG0358	DNA primase activity
IA74_RS02250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IA74_RS02260	COG1185	polyribonucleotide nucleotidyltransferase activity
IA74_RS02275	COG4771	TonB-dependent receptor
IA74_RS02320	COG3426	butyrate kinase activity
IA74_RS02325	COG0280	phosphate acetyltransferase
IA74_RS02335	COG1619	proteins homologs of microcin C7 resistance protein MccF
IA74_RS02340	COG2234	aminopeptidase activity
IA74_RS02345	COG2166	iron-sulfur cluster assembly
IA74_RS02350	COG3655	Transcriptional regulator
IA74_RS02360	COG1266	CAAX protease self-immunity
IA74_RS02365	COG0196	riboflavin kinase activity
IA74_RS02370	COG1011	Hydrolase
IA74_RS02375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IA74_RS02380	COG0784	Response regulator, receiver
IA74_RS02380	COG5002	protein histidine kinase activity
IA74_RS02385	COG1773	rubredoxin
IA74_RS02390	COG1283	sodium-dependent phosphate transmembrane transporter activity
IA74_RS02400	COG2205	protein histidine kinase activity
IA74_RS02425	COG0006	proline dipeptidase activity
IA74_RS02440	COG0509	glycine decarboxylation via glycine cleavage system
IA74_RS02445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IA74_RS02475	COG0702	epimerase
IA74_RS02480	COG4771	TonB-dependent receptor
IA74_RS02485	COG1472	Belongs to the glycosyl hydrolase 3 family
IA74_RS02495	COG0793	Belongs to the peptidase S41A family
IA74_RS02500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IA74_RS02535	COG4771	TonB-dependent receptor
IA74_RS02540	COG3292	Two component regulator propeller
IA74_RS02540	COG0745	RESPONSE REGULATOR receiver
IA74_RS02540	COG2205	protein histidine kinase activity
IA74_RS02545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IA74_RS02550	COG1882	Formate acetyltransferase
IA74_RS02555	COG2814	Major facilitator Superfamily
IA74_RS02555	COG0477	Major facilitator Superfamily
IA74_RS02580	COG0483	inositol monophosphate 1-phosphatase activity
IA74_RS02590	COG3345	alpha-galactosidase
IA74_RS02615	COG3475	LICD family
IA74_RS02620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IA74_RS02695	COG0776	regulation of translation
IA74_RS02700	COG1970	mechanosensitive ion channel activity
IA74_RS02725	COG4771	TonB-dependent receptor
IA74_RS02745	COG3292	Two component regulator propeller
IA74_RS02745	COG2205	protein histidine kinase activity
IA74_RS02745	COG0745	RESPONSE REGULATOR receiver
IA74_RS02775	COG2816	NAD+ diphosphatase activity
IA74_RS02830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IA74_RS02840	COG0674	pyruvate-flavodoxin oxidoreductase activity
IA74_RS02840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IA74_RS02845	COG1013	pyruvate-flavodoxin oxidoreductase activity
IA74_RS02850	COG0584	glycerophosphoryl diester phosphodiesterase
IA74_RS02855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IA74_RS02860	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IA74_RS02865	COG1629	transport
IA74_RS02865	COG4206	TonB-dependent receptor
IA74_RS02880	COG1629	transport
IA74_RS02915	COG1629	transport
IA74_RS02930	COG1217	gtp-binding protein TYPA
IA74_RS02935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IA74_RS02945	COG0318	PFAM AMP-dependent synthetase and ligase
IA74_RS02950	COG0784	Response regulator, receiver
IA74_RS02950	COG2205	protein histidine kinase activity
IA74_RS02950	COG5002	protein histidine kinase activity
IA74_RS02970	COG3119	arylsulfatase activity
IA74_RS02980	COG4206	TonB-dependent receptor
IA74_RS02980	COG1629	transport
IA74_RS03000	COG4591	ABC-type transport system involved in lipoprotein release permease component
IA74_RS03005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IA74_RS03020	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IA74_RS03025	COG4974	Belongs to the 'phage' integrase family
IA74_RS03040	COG0606	chelatase, subunit chli
IA74_RS03130	COG0438	transferase activity, transferring glycosyl groups
IA74_RS03155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IA74_RS03160	COG0438	transferase activity, transferring glycosyl groups
IA74_RS03170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IA74_RS03175	COG0545	Peptidyl-prolyl cis-trans isomerase
IA74_RS03180	COG0545	Peptidyl-prolyl cis-trans isomerase
IA74_RS03185	COG1522	sequence-specific DNA binding
IA74_RS03205	COG3275	phosphorelay sensor kinase activity
IA74_RS03220	COG1566	PFAM secretion protein HlyD family protein
IA74_RS03285	COG1629	transport
IA74_RS03285	COG4206	TonB-dependent receptor
IA74_RS03295	COG2814	Major facilitator Superfamily
IA74_RS03315	COG3292	Two component regulator propeller
IA74_RS03315	COG0745	RESPONSE REGULATOR receiver
IA74_RS03315	COG2205	protein histidine kinase activity
IA74_RS03320	COG1621	beta-fructofuranosidase activity
IA74_RS03375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IA74_RS03380	COG0793	Belongs to the peptidase S41A family
IA74_RS03380	COG3409	Peptidoglycan-binding domain 1 protein
IA74_RS03415	COG1053	succinate dehydrogenase
IA74_RS03420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IA74_RS03445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IA74_RS03445	COG0758	DNA mediated transformation
IA74_RS03455	COG0826	peptidase U32
IA74_RS03465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IA74_RS03480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IA74_RS03485	COG0557	exoribonuclease II activity
IA74_RS03510	COG1595	DNA-templated transcription, initiation
IA74_RS03530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IA74_RS03545	COG0012	GTP binding
IA74_RS03550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IA74_RS03555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IA74_RS03565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IA74_RS03575	COG0495	leucyl-tRNA aminoacylation
IA74_RS03580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IA74_RS03600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IA74_RS03620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IA74_RS03620	COG0731	radical SAM domain protein
IA74_RS03645	COG0659	secondary active sulfate transmembrane transporter activity
IA74_RS03650	COG1592	Rubrerythrin
IA74_RS03655	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IA74_RS03675	COG0427	acetyl-CoA hydrolase
IA74_RS03685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IA74_RS03695	COG3250	beta-galactosidase activity
IA74_RS03795	COG2177	Part of the ABC transporter FtsEX involved in
IA74_RS03805	COG1968	undecaprenyl-diphosphatase activity
IA74_RS03810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IA74_RS03815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IA74_RS03820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IA74_RS03830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IA74_RS03835	COG1611	Belongs to the LOG family
IA74_RS03850	COG0594	ribonuclease P activity
IA74_RS03855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IA74_RS03870	COG4946	Tricorn protease homolog
IA74_RS03870	COG1506	peptidase
IA74_RS03870	COG0823	Involved in the tonB-independent uptake of proteins
IA74_RS03880	COG3119	arylsulfatase activity
IA74_RS03885	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IA74_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
IA74_RS03895	COG4677	pectinesterase activity
IA74_RS03900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IA74_RS03940	COG1121	(ABC) transporter
IA74_RS03950	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IA74_RS03950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IA74_RS03970	COG0823	Involved in the tonB-independent uptake of proteins
IA74_RS03970	COG1506	peptidase
IA74_RS03975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IA74_RS03975	COG0116	Belongs to the methyltransferase superfamily
IA74_RS03980	COG1045	serine acetyltransferase
IA74_RS03985	COG3275	phosphorelay sensor kinase activity
IA74_RS03990	COG3279	Response regulator of the LytR AlgR family
IA74_RS04000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IA74_RS04000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IA74_RS04020	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IA74_RS04025	COG1694	Mazg nucleotide pyrophosphohydrolase
IA74_RS04035	COG0322	excinuclease ABC activity
IA74_RS04040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IA74_RS04065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IA74_RS04090	COG2715	membrane protein required for spore maturation
IA74_RS04100	COG2255	four-way junction helicase activity
IA74_RS04115	COG3591	Belongs to the peptidase S1B family
IA74_RS04125	COG0513	Belongs to the DEAD box helicase family
IA74_RS04135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IA74_RS04150	COG0612	Peptidase, M16
IA74_RS04170	COG1312	Catalyzes the dehydration of D-mannonate
IA74_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
IA74_RS04185	COG0681	Belongs to the peptidase S26 family
IA74_RS04195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IA74_RS04225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA74_RS04240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA74_RS04245	COG3250	beta-galactosidase activity
IA74_RS04265	COG0215	cysteine-tRNA ligase activity
IA74_RS04275	COG0561	phosphatase activity
IA74_RS04340	COG0205	6-phosphofructokinase activity
IA74_RS04350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IA74_RS04355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IA74_RS04360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IA74_RS04365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IA74_RS04375	COG1216	Glycosyl transferase, family 2
IA74_RS04395	COG1442	glycosyl transferase family 8
IA74_RS04400	COG1442	glycosyl transferase family 8
IA74_RS04400	COG1216	Glycosyl transferase, family 2
IA74_RS04410	COG1216	Glycosyl transferase, family 2
IA74_RS04410	COG1442	glycosyl transferase family 8
IA74_RS04415	COG1132	(ABC) transporter
IA74_RS04420	COG0328	RNA-DNA hybrid ribonuclease activity
IA74_RS04420	COG3341	Caulimovirus viroplasmin
IA74_RS04435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IA74_RS04445	COG0326	Molecular chaperone. Has ATPase activity
IA74_RS04455	COG1166	arginine decarboxylase activity
IA74_RS04460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IA74_RS04465	COG1595	DNA-templated transcription, initiation
IA74_RS04510	COG1454	alcohol dehydrogenase
IA74_RS04515	COG0235	Class ii aldolase
IA74_RS04520	COG1070	Carbohydrate kinase
IA74_RS04525	COG0738	Major facilitator superfamily
IA74_RS04545	COG0779	Required for maturation of 30S ribosomal subunits
IA74_RS04550	COG0195	Participates in both transcription termination and antitermination
IA74_RS04555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IA74_RS04565	COG0719	Fe-S assembly protein
IA74_RS04575	COG0396	ATPase activity
IA74_RS04580	COG0719	Fe-S assembly protein
IA74_RS04585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IA74_RS04590	COG0393	Putative heavy-metal-binding
IA74_RS04605	COG1629	transport
IA74_RS04630	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IA74_RS04635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IA74_RS04660	COG0187	DNA topoisomerase II activity
IA74_RS04665	COG0268	Binds directly to 16S ribosomal RNA
IA74_RS04675	COG1381	Involved in DNA repair and RecF pathway recombination
IA74_RS04680	COG1610	YqeY-like protein
IA74_RS04685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IA74_RS04700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IA74_RS04705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IA74_RS04710	COG0772	Belongs to the SEDS family
IA74_RS04715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IA74_RS04720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IA74_RS04725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IA74_RS04740	COG0275	rRNA processing
IA74_RS04745	COG2001	Belongs to the MraZ family
IA74_RS04765	COG4771	TonB-dependent receptor
IA74_RS04795	COG0756	dUTP diphosphatase activity
IA74_RS04810	COG4942	peptidase
IA74_RS04815	COG2205	protein histidine kinase activity
IA74_RS04815	COG0745	RESPONSE REGULATOR receiver
IA74_RS04815	COG3292	Two component regulator propeller
IA74_RS04820	COG3940	Belongs to the glycosyl hydrolase 43 family
IA74_RS04830	COG3250	beta-galactosidase activity
IA74_RS04860	COG0383	alpha-mannosidase activity
IA74_RS04860	COG0383	alpha-mannosidase activity
IA74_RS04865	COG4206	TonB-dependent receptor
IA74_RS04865	COG1629	transport
IA74_RS04885	COG3507	Belongs to the glycosyl hydrolase 43 family
IA74_RS04905	COG3537	Alpha-1,2-mannosidase
IA74_RS04915	COG2017	converts alpha-aldose to the beta-anomer
IA74_RS04960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IA74_RS04965	COG1022	Amp-dependent synthetase and ligase
IA74_RS04980	COG2954	triphosphatase activity
IA74_RS05000	COG3250	beta-galactosidase activity
IA74_RS05005	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS05010	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IA74_RS05015	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IA74_RS05035	COG1629	transport
IA74_RS05035	COG4206	TonB-dependent receptor
IA74_RS05040	COG2205	protein histidine kinase activity
IA74_RS05040	COG3292	Two component regulator propeller
IA74_RS05040	COG0745	RESPONSE REGULATOR receiver
IA74_RS05045	COG0745	RESPONSE REGULATOR receiver
IA74_RS05045	COG2205	protein histidine kinase activity
IA74_RS05045	COG3292	Two component regulator propeller
IA74_RS05070	COG4771	TonB-dependent receptor
IA74_RS05105	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
IA74_RS05130	COG4771	TonB-dependent receptor
IA74_RS05155	COG0423	glycine-tRNA ligase activity
IA74_RS05160	COG0545	Peptidyl-prolyl cis-trans isomerase
IA74_RS05170	COG3005	denitrification pathway
IA74_RS05175	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IA74_RS05185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IA74_RS05205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IA74_RS05225	COG3876	Protein conserved in bacteria
IA74_RS05245	COG0463	Glycosyl transferase, family 2
IA74_RS05245	COG1216	Glycosyl transferase, family 2
IA74_RS05265	COG3876	Protein conserved in bacteria
IA74_RS05275	COG4206	TonB-dependent receptor
IA74_RS05275	COG1629	transport
IA74_RS05285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IA74_RS05290	COG0589	response to stress
IA74_RS05290	COG0475	glutathione-regulated potassium exporter activity
IA74_RS05295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IA74_RS05310	COG0733	neurotransmitter:sodium symporter activity
IA74_RS05320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IA74_RS05330	COG0076	glutamate decarboxylase activity
IA74_RS05335	COG2066	Belongs to the glutaminase family
IA74_RS05340	COG2205	protein histidine kinase activity
IA74_RS05340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IA74_RS05345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IA74_RS05350	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IA74_RS05490	COG1346	cytolysis
IA74_RS05515	COG0280	phosphate acetyltransferase
IA74_RS05520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IA74_RS05525	COG1785	Belongs to the alkaline phosphatase family
IA74_RS05535	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA74_RS05540	COG2003	Belongs to the UPF0758 family
IA74_RS05545	COG1216	Glycosyl transferase, family 2
IA74_RS05545	COG0463	Glycosyl transferase, family 2
IA74_RS05550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IA74_RS05555	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IA74_RS05560	COG2815	serine threonine protein kinase
IA74_RS05560	COG0515	serine threonine protein kinase
IA74_RS05565	COG0564	pseudouridine synthase activity
IA74_RS05635	COG0582	viral genome integration into host DNA
IA74_RS05695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IA74_RS05700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IA74_RS05710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IA74_RS05730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IA74_RS05740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IA74_RS05740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IA74_RS05745	COG2890	protein-(glutamine-N5) methyltransferase activity
IA74_RS05750	COG2137	regulation of response to DNA damage stimulus
IA74_RS05755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IA74_RS05780	COG1929	Belongs to the glycerate kinase type-1 family
IA74_RS05790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IA74_RS05795	COG1396	sequence-specific DNA binding
IA74_RS05795	COG1917	Cupin 2, conserved barrel domain protein
IA74_RS05800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IA74_RS05805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IA74_RS05810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IA74_RS05815	COG0137	argininosuccinate synthase activity
IA74_RS05840	COG4999	Histidine kinase
IA74_RS05840	COG3850	Histidine kinase
IA74_RS05840	COG3437	response regulator, receiver
IA74_RS05840	COG2205	protein histidine kinase activity
IA74_RS05845	COG0531	amino acid
IA74_RS05855	COG0039	L-malate dehydrogenase activity
IA74_RS05860	COG2996	Protein conserved in bacteria
IA74_RS05890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IA74_RS05895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IA74_RS05910	COG4771	TonB-dependent receptor
IA74_RS05935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA74_RS05940	COG1136	(ABC) transporter
IA74_RS05940	COG0577	efflux transmembrane transporter activity
IA74_RS05945	COG1136	(ABC) transporter
IA74_RS05945	COG0577	efflux transmembrane transporter activity
IA74_RS05950	COG1136	(ABC) transporter
IA74_RS05955	COG1940	carbohydrate kinase activity
IA74_RS05960	COG0335	large ribosomal subunit rRNA binding
IA74_RS05965	COG0737	Belongs to the 5'-nucleotidase family
IA74_RS05970	COG0737	Belongs to the 5'-nucleotidase family
IA74_RS05975	COG1472	Belongs to the glycosyl hydrolase 3 family
IA74_RS05980	COG1472	Belongs to the glycosyl hydrolase 3 family
IA74_RS05985	COG1629	transport
IA74_RS05985	COG4206	TonB-dependent receptor
IA74_RS05995	COG3119	arylsulfatase activity
IA74_RS06020	COG0446	pyridine nucleotide-disulphide oxidoreductase
IA74_RS06035	COG2204	response regulator
IA74_RS06045	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IA74_RS06065	COG2205	protein histidine kinase activity
IA74_RS06070	COG5002	protein histidine kinase activity
IA74_RS06085	COG4771	TonB-dependent receptor
IA74_RS06125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IA74_RS06125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IA74_RS06130	COG0436	Aminotransferase
IA74_RS06145	COG0826	peptidase U32
IA74_RS06155	COG4771	TonB-dependent receptor
IA74_RS06165	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IA74_RS06175	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IA74_RS06185	COG3206	protein involved in exopolysaccharide biosynthesis
IA74_RS06185	COG0489	protein tyrosine kinase activity
IA74_RS06195	COG0460	homoserine dehydrogenase
IA74_RS06195	COG0527	aspartate kinase activity
IA74_RS06200	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
IA74_RS06255	COG1629	transport
IA74_RS06255	COG4206	TonB-dependent receptor
IA74_RS06260	COG0702	epimerase
IA74_RS06270	COG3250	beta-galactosidase activity
IA74_RS06280	COG3250	beta-galactosidase activity
IA74_RS06285	COG3507	Belongs to the glycosyl hydrolase 43 family
IA74_RS06300	COG4771	TonB-dependent receptor
IA74_RS06315	COG2226	methyltransferase
IA74_RS06320	COG2207	Transcriptional regulator
IA74_RS06330	COG0546	phosphoglycolate phosphatase activity
IA74_RS06345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IA74_RS06355	COG0628	permease
IA74_RS06360	COG1435	thymidine kinase activity
IA74_RS06370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IA74_RS06385	COG2095	MarC family integral membrane protein
IA74_RS06395	COG1629	transport
IA74_RS06405	COG1629	transport
IA74_RS06410	COG4974	Belongs to the 'phage' integrase family
IA74_RS06420	COG1629	transport
IA74_RS06420	COG4206	TonB-dependent receptor
IA74_RS06430	COG4771	TonB-dependent receptor
IA74_RS06435	COG0702	epimerase
IA74_RS06440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IA74_RS06460	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IA74_RS06460	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IA74_RS06475	COG0531	amino acid
IA74_RS06485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IA74_RS06490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA74_RS06500	COG1162	GTPase activity
IA74_RS06505	COG0233	cytoplasmic translational termination
IA74_RS06525	COG0443	Heat shock 70 kDa protein
IA74_RS06535	COG0528	UMP kinase activity
IA74_RS06540	COG0534	Mate efflux family protein
IA74_RS06565	COG0792	nuclease activity
IA74_RS06585	COG1183	phosphatidylcholine synthase activity
IA74_RS06590	COG0688	phosphatidylethanolamine metabolic process
IA74_RS06600	COG3118	belongs to the thioredoxin family
IA74_RS06620	COG0577	efflux transmembrane transporter activity
IA74_RS06620	COG1136	(ABC) transporter
IA74_RS06685	COG2205	protein histidine kinase activity
IA74_RS06715	COG0714	Associated with various cellular activities
IA74_RS06730	COG0802	atpase or kinase
IA74_RS06735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IA74_RS06745	COG2234	aminopeptidase activity
IA74_RS06770	COG1629	transport
IA74_RS06790	COG3250	beta-galactosidase activity
IA74_RS06805	COG0784	Response regulator, receiver
IA74_RS06805	COG2205	protein histidine kinase activity
IA74_RS06820	COG1566	PFAM secretion protein HlyD family protein
IA74_RS06840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IA74_RS06855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IA74_RS06860	COG0742	ribosomal rna small subunit methyltransferase
IA74_RS06885	COG4771	TonB-dependent receptor
IA74_RS06895	COG3537	Alpha-1,2-mannosidase
IA74_RS06910	COG3537	Alpha-1,2-mannosidase
IA74_RS06915	COG2814	Major facilitator Superfamily
IA74_RS06940	COG0739	heme binding
IA74_RS06950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IA74_RS06955	COG1388	LysM domain
IA74_RS06955	COG3942	CHAP domain
IA74_RS06965	COG1475	DNA binding
IA74_RS06970	COG1192	Involved in chromosome partitioning
IA74_RS06980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IA74_RS06985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA74_RS07000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IA74_RS07005	COG0799	negative regulation of ribosome biogenesis
IA74_RS07020	COG2239	Acts as a magnesium transporter
IA74_RS07025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IA74_RS07035	COG2195	Cleaves the N-terminal amino acid of tripeptides
IA74_RS07095	COG0668	transmembrane transport
IA74_RS07100	COG0662	Cupin 2, conserved barrel domain protein
IA74_RS07100	COG2207	Transcriptional regulator
IA74_RS07135	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IA74_RS07170	COG2244	polysaccharide biosynthetic process
IA74_RS07185	COG4641	Protein conserved in bacteria
IA74_RS07185	COG0438	transferase activity, transferring glycosyl groups
IA74_RS07205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IA74_RS07215	COG1028	Short-chain dehydrogenase reductase Sdr
IA74_RS07220	COG3475	LICD family
IA74_RS07230	COG0438	transferase activity, transferring glycosyl groups
IA74_RS07240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IA74_RS07250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IA74_RS07275	COG0667	Aldo Keto reductase
IA74_RS07280	COG1472	Belongs to the glycosyl hydrolase 3 family
IA74_RS07285	COG4771	TonB-dependent receptor
IA74_RS07290	COG0702	epimerase
IA74_RS07330	COG5012	cobalamin binding
IA74_RS07340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IA74_RS07345	COG4124	Belongs to the glycosyl hydrolase 26 family
IA74_RS07350	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IA74_RS07355	COG2211	Major facilitator Superfamily
IA74_RS07360	COG2942	2-epimerase
IA74_RS07400	COG1404	Belongs to the peptidase S8 family
IA74_RS07400	COG4412	M6 family metalloprotease domain protein
IA74_RS07410	COG2205	protein histidine kinase activity
IA74_RS07410	COG0784	Response regulator, receiver
IA74_RS07410	COG5002	protein histidine kinase activity
IA74_RS07420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IA74_RS07425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IA74_RS07430	COG0713	ATP synthesis coupled electron transport
IA74_RS07435	COG0839	Belongs to the complex I subunit 6 family
IA74_RS07445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IA74_RS07450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IA74_RS07450	COG0649	NAD binding
IA74_RS07455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IA74_RS07460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IA74_RS07470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IA74_RS07475	COG0569	domain protein
IA74_RS07480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IA74_RS07485	COG1073	alpha beta
IA74_RS07500	COG0546	phosphoglycolate phosphatase activity
IA74_RS07505	COG3119	arylsulfatase activity
IA74_RS07520	COG3119	arylsulfatase activity
IA74_RS07530	COG1629	transport
IA74_RS07535	COG0745	RESPONSE REGULATOR receiver
IA74_RS07535	COG2205	protein histidine kinase activity
IA74_RS07535	COG3292	Two component regulator propeller
IA74_RS07540	COG2271	Major facilitator Superfamily
IA74_RS07560	COG0805	protein transport
IA74_RS07565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IA74_RS07570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IA74_RS07590	COG4585	Histidine kinase
IA74_RS07605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IA74_RS07615	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA74_RS07620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IA74_RS07620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IA74_RS07625	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA74_RS07630	COG1078	dGTPase activity
IA74_RS07635	COG0284	orotidine-5'-phosphate decarboxylase activity
IA74_RS07640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IA74_RS07645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IA74_RS07655	COG1704	LemA family
IA74_RS07670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IA74_RS07675	COG2226	methyltransferase
IA74_RS07680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IA74_RS07685	COG1702	phosphate starvation-inducible protein PhoH
IA74_RS07695	COG2268	Band 7 protein
IA74_RS07705	COG5434	Belongs to the glycosyl hydrolase 28 family
IA74_RS07715	COG0101	tRNA pseudouridine synthase activity
IA74_RS07735	COG3250	beta-galactosidase activity
IA74_RS07740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IA74_RS07765	COG0457	Tetratricopeptide repeat
IA74_RS07770	COG2814	Major facilitator Superfamily
IA74_RS07795	COG0702	epimerase
IA74_RS07800	COG4206	TonB-dependent receptor
IA74_RS07800	COG1629	transport
IA74_RS07810	COG4771	TonB-dependent receptor
IA74_RS07820	COG1629	transport
IA74_RS07820	COG4206	TonB-dependent receptor
IA74_RS07835	COG4206	TonB-dependent receptor
IA74_RS07835	COG1629	transport
IA74_RS07840	COG0702	epimerase
IA74_RS07845	COG0673	inositol 2-dehydrogenase activity
IA74_RS07885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IA74_RS07890	COG0793	Belongs to the peptidase S41A family
IA74_RS07895	COG2131	deaminase
IA74_RS07905	COG0339	signal peptide processing
IA74_RS07915	COG1970	mechanosensitive ion channel activity
IA74_RS07920	COG0519	Catalyzes the synthesis of GMP from XMP
IA74_RS07920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IA74_RS07930	COG4771	TonB-dependent receptor
IA74_RS07935	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IA74_RS07945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IA74_RS07955	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IA74_RS07980	COG1242	4 iron, 4 sulfur cluster binding
IA74_RS07990	COG0363	glucosamine-6-phosphate deaminase activity
IA74_RS08000	COG0009	L-threonylcarbamoyladenylate synthase
IA74_RS08010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IA74_RS08015	COG0561	phosphatase activity
IA74_RS08020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IA74_RS08025	COG0626	cystathionine gamma-synthase activity
IA74_RS08080	COG0297	glycogen (starch) synthase activity
IA74_RS08085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IA74_RS08090	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IA74_RS08095	COG0543	2 iron, 2 sulfur cluster binding
IA74_RS08105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IA74_RS08115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IA74_RS08120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IA74_RS08135	COG0546	phosphoglycolate phosphatase activity
IA74_RS08140	COG0791	NLP P60 protein
IA74_RS08145	COG1131	(ABC) transporter
IA74_RS08155	COG0612	Peptidase, M16
IA74_RS08160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IA74_RS08165	COG1597	lipid kinase activity
IA74_RS08180	COG1136	(ABC) transporter
IA74_RS08200	COG2211	Major facilitator Superfamily
IA74_RS08210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IA74_RS08225	COG1674	ftsk spoiiie
IA74_RS08235	COG0492	ferredoxin-NADP+ reductase activity
IA74_RS08240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS08280	COG1595	DNA-templated transcription, initiation
IA74_RS08295	COG3956	TIGRFAM MazG family protein
IA74_RS08305	COG0525	valine-tRNA ligase activity
IA74_RS08330	COG4771	TonB-dependent receptor
IA74_RS08345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IA74_RS08360	COG4771	TonB-dependent receptor
IA74_RS08365	COG0702	epimerase
IA74_RS08370	COG3119	arylsulfatase activity
IA74_RS08375	COG3119	arylsulfatase activity
IA74_RS08395	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
IA74_RS08405	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IA74_RS08425	COG1253	flavin adenine dinucleotide binding
IA74_RS08435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IA74_RS08445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IA74_RS08485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IA74_RS08535	COG1216	Glycosyl transferase, family 2
IA74_RS08570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IA74_RS08585	COG4771	TonB-dependent receptor
IA74_RS08595	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IA74_RS08600	COG0563	adenylate kinase activity
IA74_RS08605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IA74_RS08610	COG1496	oxidoreductase activity
IA74_RS08630	COG2706	6-phosphogluconolactonase activity
IA74_RS08650	COG2207	Transcriptional regulator
IA74_RS08670	COG1288	antiporter activity
IA74_RS08705	COG0454	-acetyltransferase
IA74_RS08710	COG0564	pseudouridine synthase activity
IA74_RS08725	COG1501	Belongs to the glycosyl hydrolase 31 family
IA74_RS08755	COG3011	Protein conserved in bacteria
IA74_RS08770	COG0148	phosphopyruvate hydratase activity
IA74_RS08785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IA74_RS08790	COG1082	Xylose isomerase domain protein TIM barrel
IA74_RS08820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IA74_RS08825	COG0193	aminoacyl-tRNA hydrolase activity
IA74_RS08830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IA74_RS08840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IA74_RS08845	COG1862	Preprotein translocase
IA74_RS08855	COG0237	dephospho-CoA kinase activity
IA74_RS08870	COG0542	response to heat
IA74_RS08880	COG0583	DNA-binding transcription factor activity
IA74_RS08885	COG2855	membrane
IA74_RS08900	COG1595	DNA-templated transcription, initiation
IA74_RS08915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IA74_RS08935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IA74_RS08955	COG0443	Heat shock 70 kDa protein
IA74_RS09035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IA74_RS09040	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
IA74_RS09045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IA74_RS09065	COG1501	Belongs to the glycosyl hydrolase 31 family
IA74_RS09085	COG4206	TonB-dependent receptor
IA74_RS09085	COG1629	transport
IA74_RS09095	COG1408	metallophosphoesterase
IA74_RS09105	COG3634	alkyl hydroperoxide reductase activity
IA74_RS09140	COG1760	l-serine dehydratase
IA74_RS09145	COG0598	Magnesium transport protein CorA
IA74_RS09150	COG1193	negative regulation of DNA recombination
IA74_RS09180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IA74_RS09225	COG0411	ABC transporter
IA74_RS09245	COG0194	GDP metabolic process
IA74_RS09265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA74_RS09275	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IA74_RS09285	COG0110	maltose O-acetyltransferase activity
IA74_RS09305	COG0438	transferase activity, transferring glycosyl groups
IA74_RS09315	COG1216	Glycosyl transferase, family 2
IA74_RS09320	COG0463	Glycosyl transferase, family 2
IA74_RS09360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IA74_RS09440	COG0358	DNA primase activity
IA74_RS09565	COG2204	response regulator
IA74_RS09570	COG2198	Histidine kinase
IA74_RS09570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IA74_RS09570	COG2205	protein histidine kinase activity
IA74_RS09570	COG0784	Response regulator, receiver
IA74_RS09630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IA74_RS09630	COG0551	DNA topoisomerase type I activity
IA74_RS09670	COG4974	Belongs to the 'phage' integrase family
IA74_RS09720	COG4974	Belongs to the 'phage' integrase family
IA74_RS09725	COG4974	Belongs to the 'phage' integrase family
IA74_RS09750	COG4804	nuclease activity
IA74_RS09760	COG0784	Response regulator, receiver
IA74_RS09760	COG2205	protein histidine kinase activity
IA74_RS09765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IA74_RS09770	COG2195	Cleaves the N-terminal amino acid of tripeptides
IA74_RS09775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IA74_RS09780	COG3189	MarR family transcriptional regulator
IA74_RS09785	COG2885	chlorophyll binding
IA74_RS09795	COG2217	Heavy metal translocating P-type atpase
IA74_RS09800	COG2855	membrane
IA74_RS09810	COG4771	TonB-dependent receptor
IA74_RS09820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IA74_RS09820	COG2207	Transcriptional regulator
IA74_RS09840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IA74_RS09840	COG4651	solute:proton antiporter activity
IA74_RS09845	COG1280	lysine exporter protein (LysE YggA)
IA74_RS09860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IA74_RS09865	COG0561	phosphatase activity
IA74_RS09870	COG1169	isochorismate synthase
IA74_RS09875	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IA74_RS09885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IA74_RS09890	COG4948	Mandelate Racemase Muconate Lactonizing
IA74_RS09905	COG1082	Xylose isomerase domain protein TIM barrel
IA74_RS09920	COG4771	TonB-dependent receptor
IA74_RS09950	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IA74_RS09955	COG0783	Belongs to the Dps family
IA74_RS09980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IA74_RS10005	COG2755	lipolytic protein G-D-S-L family
IA74_RS10005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IA74_RS10030	COG1253	flavin adenine dinucleotide binding
IA74_RS10035	COG0501	Belongs to the peptidase M48B family
IA74_RS10065	COG2873	o-acetylhomoserine
IA74_RS10085	COG1757	Na H antiporter
IA74_RS10100	COG2814	Major facilitator Superfamily
IA74_RS10105	COG4953	penicillin-binding protein 1C
IA74_RS10110	COG2373	Large extracellular alpha-helical protein
IA74_RS10120	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IA74_RS10120	COG1918	ferrous iron import across plasma membrane
IA74_RS10180	COG1086	Polysaccharide biosynthesis protein
IA74_RS10185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IA74_RS10195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IA74_RS10225	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IA74_RS10230	COG0463	Glycosyl transferase, family 2
IA74_RS10230	COG1216	Glycosyl transferase, family 2
IA74_RS10240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IA74_RS10260	COG0471	metal ion transport
IA74_RS10260	COG0490	domain, Protein
IA74_RS10275	COG0346	lactoylglutathione lyase activity
IA74_RS10290	COG0259	pyridoxamine-phosphate oxidase activity
IA74_RS10295	COG1741	Belongs to the pirin family
IA74_RS10310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IA74_RS10340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IA74_RS10350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IA74_RS10365	COG1595	DNA-templated transcription, initiation
IA74_RS10390	COG0686	Belongs to the AlaDH PNT family
IA74_RS10410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IA74_RS10425	COG1629	transport
IA74_RS10440	COG3345	alpha-galactosidase
IA74_RS10465	COG0488	(ABC) transporter
IA74_RS10470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IA74_RS10475	COG3059	membrane
IA74_RS10480	COG0662	Cupin 2, conserved barrel domain protein
IA74_RS10480	COG2207	Transcriptional regulator
IA74_RS10485	COG0295	cytidine deaminase activity
IA74_RS10490	COG1705	Flagellar rod assembly protein muramidase FlgJ
IA74_RS10490	COG1388	LysM domain
IA74_RS10505	COG0577	efflux transmembrane transporter activity
IA74_RS10515	COG0577	efflux transmembrane transporter activity
IA74_RS10525	COG0577	efflux transmembrane transporter activity
IA74_RS10535	COG0577	efflux transmembrane transporter activity
IA74_RS10535	COG1136	(ABC) transporter
IA74_RS10545	COG0662	Cupin 2, conserved barrel domain protein
IA74_RS10545	COG2207	Transcriptional regulator
IA74_RS10560	COG1136	(ABC) transporter
IA74_RS10565	COG1136	(ABC) transporter
IA74_RS10585	COG2205	protein histidine kinase activity
IA74_RS10585	COG0784	Response regulator, receiver
IA74_RS10595	COG2204	response regulator
IA74_RS10600	COG4191	Histidine kinase
IA74_RS10650	COG0732	type I restriction modification DNA specificity domain
IA74_RS10655	COG0732	type I restriction modification DNA specificity domain
IA74_RS10660	COG4974	Belongs to the 'phage' integrase family
IA74_RS10720	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IA74_RS10730	COG1088	dTDP-glucose 4,6-dehydratase activity
IA74_RS10745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IA74_RS10755	COG2076	Multidrug Resistance protein
IA74_RS10820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA74_RS10825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IA74_RS10830	COG1530	ribonuclease E activity
IA74_RS10845	COG3119	arylsulfatase activity
IA74_RS10850	COG0629	single-stranded DNA binding
IA74_RS10915	COG4206	TonB-dependent receptor
IA74_RS10940	COG0745	RESPONSE REGULATOR receiver
IA74_RS10965	COG0488	(ABC) transporter
IA74_RS10980	COG5492	domain, Protein
IA74_RS10990	COG0436	Aminotransferase
IA74_RS10995	COG4591	ABC-type transport system involved in lipoprotein release permease component
IA74_RS11000	COG1215	transferase activity, transferring glycosyl groups
IA74_RS11005	COG0628	permease
IA74_RS11025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA74_RS11035	COG1136	(ABC) transporter
IA74_RS11035	COG0577	efflux transmembrane transporter activity
IA74_RS11040	COG1136	(ABC) transporter
IA74_RS11040	COG0577	efflux transmembrane transporter activity
IA74_RS11045	COG1252	NADH dehydrogenase
IA74_RS11075	COG4771	TonB-dependent receptor
IA74_RS11085	COG1620	l-lactate permease
IA74_RS11105	COG2885	chlorophyll binding
IA74_RS11105	COG3047	cAMP biosynthetic process
IA74_RS11115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IA74_RS11120	COG0439	Biotin carboxylase
IA74_RS11125	COG0511	ligase activity, forming carbon-carbon bonds
IA74_RS11135	COG2226	methyltransferase
IA74_RS11140	COG0402	S-adenosylhomocysteine deaminase activity
IA74_RS11175	COG2205	protein histidine kinase activity
IA74_RS11175	COG2198	Histidine kinase
IA74_RS11175	COG0784	Response regulator, receiver
IA74_RS11180	COG0508	dehydrogenase complex catalyzes the overall conversion of
IA74_RS11185	COG0022	dehydrogenase e1 component
IA74_RS11190	COG0716	FMN binding
IA74_RS11195	COG2264	protein methyltransferase activity
IA74_RS11210	COG0590	tRNA wobble adenosine to inosine editing
IA74_RS11235	COG0673	inositol 2-dehydrogenase activity
IA74_RS11240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IA74_RS11290	COG0698	ribose 5-phosphate isomerase
IA74_RS11295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IA74_RS11300	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IA74_RS11315	COG1482	cell wall glycoprotein biosynthetic process
IA74_RS11335	COG0513	Belongs to the DEAD box helicase family
IA74_RS11340	COG4221	oxidoreductase activity
IA74_RS11350	COG3250	beta-galactosidase activity
IA74_RS11360	COG3273	potassium ion transport
IA74_RS11360	COG0471	metal ion transport
IA74_RS11365	COG0529	Catalyzes the synthesis of activated sulfate
IA74_RS11370	COG0175	sulfate reduction
IA74_RS11390	COG2885	chlorophyll binding
IA74_RS11410	COG4974	Belongs to the 'phage' integrase family
IA74_RS11435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IA74_RS11440	COG0242	peptide deformylase activity
IA74_RS11455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IA74_RS11460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IA74_RS11465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IA74_RS11470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IA74_RS11480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IA74_RS11485	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IA74_RS11500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IA74_RS11540	COG1940	carbohydrate kinase activity
IA74_RS11545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IA74_RS11555	COG2271	Major facilitator Superfamily
IA74_RS11560	COG2731	YhcH YjgK YiaL family protein
IA74_RS11565	COG1629	transport
IA74_RS11570	COG0702	epimerase
IA74_RS11580	COG1629	transport
IA74_RS11585	COG0702	epimerase
IA74_RS11605	COG4771	TonB-dependent receptor
IA74_RS11610	COG0702	epimerase
IA74_RS11615	COG0702	epimerase
IA74_RS11620	COG4206	TonB-dependent receptor
IA74_RS11620	COG1629	transport
IA74_RS11625	COG4206	TonB-dependent receptor
IA74_RS11625	COG1629	transport
IA74_RS11640	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS11660	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS11670	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS11675	COG3537	Alpha-1,2-mannosidase
IA74_RS11680	COG3250	beta-galactosidase activity
IA74_RS11685	COG4771	TonB-dependent receptor
IA74_RS11690	COG0702	epimerase
IA74_RS11705	COG0484	heat shock protein binding
IA74_RS11710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IA74_RS11715	COG0488	(ABC) transporter
IA74_RS11720	COG1595	DNA-templated transcription, initiation
IA74_RS11775	COG2885	chlorophyll binding
IA74_RS11890	COG2183	response to ionizing radiation
IA74_RS11895	COG2205	protein histidine kinase activity
IA74_RS11895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IA74_RS11900	COG0737	Belongs to the 5'-nucleotidase family
IA74_RS11905	COG1956	GAF domain-containing protein
IA74_RS11915	COG4771	TonB-dependent receptor
IA74_RS11935	COG4974	Belongs to the 'phage' integrase family
IA74_RS11975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IA74_RS11975	COG0551	DNA topoisomerase type I activity
IA74_RS11995	COG2205	protein histidine kinase activity
IA74_RS11995	COG2198	Histidine kinase
IA74_RS11995	COG0784	Response regulator, receiver
IA74_RS11995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IA74_RS12125	COG0358	DNA primase activity
IA74_RS12215	COG0534	Mate efflux family protein
IA74_RS12230	COG4771	TonB-dependent receptor
IA74_RS12265	COG0534	Mate efflux family protein
IA74_RS12275	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
IA74_RS12285	COG0318	PFAM AMP-dependent synthetase and ligase
IA74_RS12290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA74_RS12295	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IA74_RS12335	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IA74_RS12340	COG1086	Polysaccharide biosynthesis protein
IA74_RS12345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IA74_RS12355	COG2089	acid synthase
IA74_RS12360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IA74_RS12365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IA74_RS12370	COG1083	cytidylyl-transferase
IA74_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
IA74_RS12415	COG1216	Glycosyl transferase, family 2
IA74_RS12415	COG1442	glycosyl transferase family 8
IA74_RS12420	COG1086	Polysaccharide biosynthesis protein
IA74_RS12430	COG1091	dTDP-4-dehydrorhamnose reductase activity
IA74_RS12440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA74_RS12445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IA74_RS12655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IA74_RS12675	COG4245	von Willebrand factor, type A
IA74_RS12680	COG2304	oxidoreductase activity
IA74_RS12685	COG4245	von Willebrand factor, type A
IA74_RS12720	COG0248	Ppx GppA phosphatase
IA74_RS12725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IA74_RS12735	COG1629	transport
IA74_RS12740	COG0561	phosphatase activity
IA74_RS12780	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IA74_RS12785	COG4771	TonB-dependent receptor
IA74_RS12905	COG1705	Flagellar rod assembly protein muramidase FlgJ
IA74_RS12905	COG1388	LysM domain
IA74_RS12975	COG0741	lytic transglycosylase activity
IA74_RS12975	COG1196	nuclear chromosome segregation
IA74_RS12975	COG0739	heme binding
IA74_RS12995	COG3279	Response regulator of the LytR AlgR family
IA74_RS13020	COG0629	single-stranded DNA binding
IA74_RS13035	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IA74_RS13055	COG1192	Involved in chromosome partitioning
IA74_RS13070	COG1475	DNA binding
IA74_RS13200	COG0202	RNA polymerase activity
IA74_RS13265	COG4974	Belongs to the 'phage' integrase family
IA74_RS13290	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IA74_RS13295	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IA74_RS13300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IA74_RS13305	COG0363	glucosamine-6-phosphate deaminase activity
IA74_RS13350	COG1742	UPF0060 membrane protein
IA74_RS13380	COG3279	Response regulator of the LytR AlgR family
IA74_RS13390	COG1136	(ABC) transporter
IA74_RS13390	COG0577	efflux transmembrane transporter activity
IA74_RS13395	COG1136	(ABC) transporter
IA74_RS13400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA74_RS13435	COG3831	ATPase activity
IA74_RS13435	COG4884	unkown
IA74_RS13450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IA74_RS13460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IA74_RS13465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IA74_RS13470	COG3250	beta-galactosidase activity
IA74_RS13495	COG0501	Belongs to the peptidase M48B family
IA74_RS13500	COG1704	LemA family
IA74_RS13505	COG1595	DNA-templated transcription, initiation
IA74_RS13515	COG1629	transport
IA74_RS13515	COG4206	TonB-dependent receptor
IA74_RS13525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IA74_RS13530	COG2885	chlorophyll binding
IA74_RS13530	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IA74_RS13540	COG0697	spore germination
IA74_RS13570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IA74_RS13575	COG0656	L-ascorbic acid biosynthetic process
IA74_RS13585	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IA74_RS13590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IA74_RS13595	COG2814	Major facilitator Superfamily
IA74_RS13600	COG4771	TonB-dependent receptor
IA74_RS13630	COG4771	TonB-dependent receptor
IA74_RS13675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IA74_RS13680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IA74_RS13750	COG0666	response to abiotic stimulus
IA74_RS13755	COG0666	response to abiotic stimulus
IA74_RS13820	COG4974	Belongs to the 'phage' integrase family
IA74_RS13940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IA74_RS13940	COG0551	DNA topoisomerase type I activity
IA74_RS14020	COG3344	reverse transcriptase
IA74_RS14100	COG2003	Belongs to the UPF0758 family
IA74_RS14115	COG4974	Belongs to the 'phage' integrase family
IA74_RS14130	COG0488	(ABC) transporter
IA74_RS14150	COG3850	Histidine kinase
IA74_RS14150	COG2205	protein histidine kinase activity
IA74_RS14150	COG4999	Histidine kinase
IA74_RS14150	COG3437	response regulator, receiver
IA74_RS14170	COG0438	transferase activity, transferring glycosyl groups
IA74_RS14180	COG2244	polysaccharide biosynthetic process
IA74_RS14185	COG1442	glycosyl transferase family 8
IA74_RS14185	COG1216	Glycosyl transferase, family 2
IA74_RS14225	COG3023	N-Acetylmuramoyl-L-alanine amidase
IA74_RS14240	COG1215	transferase activity, transferring glycosyl groups
IA74_RS14270	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IA74_RS14275	COG1805	sodium ion transport
IA74_RS14280	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IA74_RS14305	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IA74_RS14310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IA74_RS14320	COG0545	Peptidyl-prolyl cis-trans isomerase
IA74_RS14325	COG1739	Uncharacterized protein family UPF0029
IA74_RS14335	COG0778	Nitroreductase
IA74_RS14340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IA74_RS14340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IA74_RS14345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IA74_RS14375	COG2217	Heavy metal translocating P-type atpase
IA74_RS14385	COG0321	lipoyl(octanoyl) transferase activity
IA74_RS14405	COG3852	Histidine kinase
IA74_RS14410	COG2204	response regulator
IA74_RS14425	COG1136	(ABC) transporter
IA74_RS14440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IA74_RS14450	COG1755	Isoprenylcysteine carboxyl methyltransferase
IA74_RS14460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IA74_RS14475	COG1678	Uncharacterized ACR, COG1678
IA74_RS14520	COG4771	TonB-dependent receptor
IA74_RS14530	COG3119	arylsulfatase activity
IA74_RS14535	COG3250	beta-galactosidase activity
IA74_RS14550	COG0681	Belongs to the peptidase S26 family
IA74_RS14585	COG3969	phosphoadenosine phosphosulfate
IA74_RS14590	COG1475	DNA binding
IA74_RS14635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA74_RS14640	COG0745	RESPONSE REGULATOR receiver
IA74_RS14655	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS14665	COG4206	TonB-dependent receptor
IA74_RS14665	COG1629	transport
IA74_RS14675	COG4974	Belongs to the 'phage' integrase family
IA74_RS14790	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IA74_RS14810	COG1022	Amp-dependent synthetase and ligase
IA74_RS14815	COG3263	regulation of cellular component size
IA74_RS14825	COG1151	hydroxylamine reductase activity
IA74_RS14840	COG2204	response regulator
IA74_RS14860	COG1136	(ABC) transporter
IA74_RS14860	COG0577	efflux transmembrane transporter activity
IA74_RS14870	COG0577	efflux transmembrane transporter activity
IA74_RS14870	COG1136	(ABC) transporter
IA74_RS14880	COG0534	Mate efflux family protein
IA74_RS14890	COG0167	dihydroorotate dehydrogenase activity
IA74_RS14895	COG2755	lipolytic protein G-D-S-L family
IA74_RS14895	COG0657	acetylesterase activity
IA74_RS14900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IA74_RS14915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IA74_RS15035	COG3344	reverse transcriptase
IA74_RS15145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IA74_RS15145	COG0551	DNA topoisomerase type I activity
IA74_RS15225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IA74_RS15230	COG1120	ATPase activity
IA74_RS15235	COG2205	protein histidine kinase activity
IA74_RS15235	COG2198	Histidine kinase
IA74_RS15235	COG0784	Response regulator, receiver
IA74_RS15240	COG2204	response regulator
IA74_RS15270	COG0582	viral genome integration into host DNA
IA74_RS15290	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IA74_RS15300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IA74_RS15310	COG0356	it plays a direct role in the translocation of protons across the membrane
IA74_RS15315	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IA74_RS15320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IA74_RS15325	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IA74_RS15330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IA74_RS15335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IA74_RS15340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IA74_RS15345	COG3118	belongs to the thioredoxin family
IA74_RS15365	COG0745	RESPONSE REGULATOR receiver
IA74_RS15370	COG5002	protein histidine kinase activity
IA74_RS15400	COG1120	ATPase activity
IA74_RS15405	COG1091	dTDP-4-dehydrorhamnose reductase activity
IA74_RS15445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IA74_RS15450	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IA74_RS15470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IA74_RS15475	COG1064	alcohol dehydrogenase
IA74_RS15490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IA74_RS15540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IA74_RS15560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IA74_RS15580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IA74_RS15655	COG2205	protein histidine kinase activity
IA74_RS15655	COG2202	Pas domain
IA74_RS15660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IA74_RS15670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IA74_RS15685	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IA74_RS15690	COG0540	Belongs to the ATCase OTCase family
IA74_RS15700	COG2431	L-lysine efflux transmembrane transporter activity
IA74_RS15730	COG2837	iron assimilation
IA74_RS15740	COG1629	transport
IA74_RS15740	COG4206	TonB-dependent receptor
IA74_RS15795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IA74_RS15805	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IA74_RS15820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IA74_RS15825	COG2205	protein histidine kinase activity
IA74_RS15845	COG2135	peptidase activity
IA74_RS15855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IA74_RS15860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IA74_RS15885	COG0673	inositol 2-dehydrogenase activity
IA74_RS15900	COG2223	nitrite transmembrane transporter activity
IA74_RS15920	COG0671	phosphoesterase, PA-phosphatase related
IA74_RS15935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IA74_RS15940	COG0045	succinate-CoA ligase (ADP-forming) activity
IA74_RS15945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IA74_RS15950	COG0351	phosphomethylpyrimidine kinase
IA74_RS15970	COG0477	Major facilitator Superfamily
IA74_RS15970	COG2814	Major facilitator Superfamily
IA74_RS15980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IA74_RS15980	COG3153	acetyltransferase
IA74_RS15985	COG0450	alkyl hydroperoxide reductase
IA74_RS15990	COG0724	RNA recognition motif
IA74_RS15995	COG1858	cytochrome C peroxidase
IA74_RS16000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IA74_RS16025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IA74_RS16035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IA74_RS16050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IA74_RS16130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IA74_RS16140	COG1904	glucuronate isomerase
IA74_RS16170	COG0513	Belongs to the DEAD box helicase family
IA74_RS16175	COG0560	Phosphoserine phosphatase
IA74_RS16175	COG3830	Belongs to the UPF0237 family
IA74_RS16200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IA74_RS16205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IA74_RS16260	COG2204	response regulator
IA74_RS16310	COG0577	efflux transmembrane transporter activity
IA74_RS16310	COG1136	(ABC) transporter
IA74_RS16320	COG0156	8-amino-7-oxononanoate synthase activity
IA74_RS16325	COG1597	lipid kinase activity
IA74_RS16330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IA74_RS16355	COG0577	efflux transmembrane transporter activity
IA74_RS16355	COG1136	(ABC) transporter
IA74_RS16380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IA74_RS16410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IA74_RS16430	COG0543	2 iron, 2 sulfur cluster binding
IA74_RS16435	COG0167	dihydroorotate dehydrogenase activity
IA74_RS16440	COG0336	Belongs to the RNA methyltransferase TrmD family
IA74_RS16445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IA74_RS16450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IA74_RS16475	COG0326	Molecular chaperone. Has ATPase activity
IA74_RS16480	COG0542	response to heat
IA74_RS16525	COG2304	oxidoreductase activity
IA74_RS16540	COG0714	Associated with various cellular activities
IA74_RS16545	COG1652	LysM domain
IA74_RS16555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IA74_RS16560	COG0552	protein localization to endoplasmic reticulum
IA74_RS16570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IA74_RS16575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IA74_RS16580	COG1058	Belongs to the CinA family
IA74_RS16580	COG1546	Belongs to the CinA family
IA74_RS16585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IA74_RS16600	COG0442	prolyl-tRNA aminoacylation
IA74_RS16615	COG0793	Belongs to the peptidase S41A family
IA74_RS16615	COG4946	Tricorn protease homolog
IA74_RS16635	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IA74_RS16650	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IA74_RS16660	COG1492	cobalamin metabolic process
IA74_RS16705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA74_RS16725	COG2096	Adenosyltransferase
IA74_RS16730	COG1797	cobyrinic acid a,c-diamide synthase activity
IA74_RS16745	COG2966	Psort location CytoplasmicMembrane, score
IA74_RS16760	COG4771	TonB-dependent receptor
IA74_RS16770	COG4774	siderophore transport
IA74_RS16795	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IA74_RS16895	COG0305	Participates in initiation and elongation during chromosome replication
IA74_RS16905	COG3023	N-Acetylmuramoyl-L-alanine amidase
IA74_RS16970	COG0352	thiamine-phosphate diphosphorylase activity
IA74_RS16975	COG2022	thiamine diphosphate biosynthetic process
IA74_RS16980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IA74_RS16995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IA74_RS17000	COG0352	thiamine-phosphate diphosphorylase activity
IA74_RS17015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IA74_RS17015	COG0574	Belongs to the PEP-utilizing enzyme family
IA74_RS17020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IA74_RS17025	COG0564	pseudouridine synthase activity
IA74_RS17040	COG0024	Methionine aminopeptidase
IA74_RS17060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IA74_RS17070	COG0481	GTPase activity
IA74_RS17090	COG0708	Exodeoxyribonuclease III
IA74_RS17095	COG1914	H( )-stimulated, divalent metal cation uptake system
IA74_RS17110	COG0217	transcriptional regulatory protein
IA74_RS17115	COG0072	phenylalanine-tRNA ligase activity
IA74_RS17115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IA74_RS17120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IA74_RS17125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA74_RS17155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IA74_RS17160	COG0463	Glycosyl transferase, family 2
IA74_RS17170	COG3475	LICD family
IA74_RS17180	COG1979	alcohol dehydrogenase
IA74_RS17185	COG0028	Belongs to the TPP enzyme family
IA74_RS17185	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
IA74_RS17215	COG0305	Participates in initiation and elongation during chromosome replication
IA74_RS17220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IA74_RS17235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IA74_RS17240	COG4657	Part of a membrane complex involved in electron transport
IA74_RS17245	COG4660	Part of a membrane complex involved in electron transport
IA74_RS17250	COG4659	FMN binding
IA74_RS17255	COG4658	electron transport chain
IA74_RS17260	COG4656	Part of a membrane complex involved in electron transport
IA74_RS17285	COG0504	CTP synthase activity
IA74_RS17295	COG0534	Mate efflux family protein
IA74_RS17300	COG0823	Involved in the tonB-independent uptake of proteins
IA74_RS17300	COG1506	peptidase
IA74_RS17315	COG0110	maltose O-acetyltransferase activity
IA74_RS17325	COG1695	Transcriptional regulator
IA74_RS17340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IA74_RS17350	COG3942	CHAP domain
IA74_RS17350	COG1388	LysM domain
IA74_RS17380	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IA74_RS17385	COG0556	nucleotide-excision repair
IA74_RS17390	COG2949	membrane
IA74_RS17400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IA74_RS17420	COG0842	Transport permease protein
IA74_RS17425	COG0842	Transport permease protein
IA74_RS17430	COG1131	(ABC) transporter
IA74_RS17465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IA74_RS17470	COG0505	Belongs to the CarA family
IA74_RS17485	COG0069	glutamate synthase activity
IA74_RS17485	COG0067	glutamate synthase
IA74_RS17485	COG0070	glutamate synthase
IA74_RS17495	COG0367	asparagine synthase
IA74_RS17510	COG3275	phosphorelay sensor kinase activity
IA74_RS17540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IA74_RS17550	COG1979	alcohol dehydrogenase
IA74_RS17560	COG0133	tryptophan synthase activity
IA74_RS17565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IA74_RS17580	COG0134	indole-3-glycerol-phosphate synthase activity
IA74_RS17585	COG0135	phosphoribosylanthranilate isomerase activity
IA74_RS17590	COG0159	tryptophan synthase activity
IA74_RS17595	COG0252	asparaginase activity
IA74_RS17605	COG0745	RESPONSE REGULATOR receiver
IA74_RS17605	COG2205	protein histidine kinase activity
IA74_RS17605	COG3292	Two component regulator propeller
IA74_RS17610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IA74_RS17620	COG0110	maltose O-acetyltransferase activity
IA74_RS17625	COG2197	response regulator
IA74_RS17635	COG0138	bifunctional purine biosynthesis protein purh
IA74_RS17640	COG0716	FMN binding
IA74_RS17665	COG1858	cytochrome C peroxidase
IA74_RS17675	COG4771	TonB-dependent receptor
IA74_RS17690	COG1132	(ABC) transporter
IA74_RS17705	COG2814	Major facilitator Superfamily
IA74_RS17710	COG1566	PFAM secretion protein HlyD family protein
IA74_RS17720	COG1230	cation diffusion facilitator family transporter
IA74_RS17740	COG4771	TonB-dependent receptor
IA74_RS17770	COG3610	response to peptide
IA74_RS17785	COG1609	Transcriptional regulator
IA74_RS17795	COG1733	regulation of RNA biosynthetic process
IA74_RS17805	COG0784	Response regulator, receiver
IA74_RS17805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IA74_RS17805	COG2205	protein histidine kinase activity
IA74_RS17805	COG2198	Histidine kinase
IA74_RS17815	COG5002	protein histidine kinase activity
IA74_RS17820	COG0745	RESPONSE REGULATOR receiver
IA74_RS17840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IA74_RS17845	COG1690	Belongs to the RtcB family
IA74_RS17865	COG0228	four-way junction DNA binding
IA74_RS17880	COG0724	RNA recognition motif
IA74_RS17890	COG1177	transmembrane transport
IA74_RS17895	COG1176	ABC-type spermidine putrescine transport system, permease component I
IA74_RS17905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IA74_RS17920	COG0058	SHG alpha-glucan phosphorylase activity
IA74_RS17930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IA74_RS17950	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IA74_RS18010	COG0745	RESPONSE REGULATOR receiver
IA74_RS18015	COG5002	protein histidine kinase activity
IA74_RS18050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IA74_RS18060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IA74_RS18070	COG4948	Mandelate Racemase Muconate Lactonizing
IA74_RS18085	COG1295	ribonuclease BN
IA74_RS18090	COG0778	Nitroreductase
IA74_RS18100	COG0704	Plays a role in the regulation of phosphate uptake
IA74_RS18105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IA74_RS18110	COG0581	inorganic phosphate transmembrane transporter activity
IA74_RS18115	COG0573	inorganic phosphate transmembrane transporter activity
IA74_RS18125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IA74_RS18135	COG0586	Pfam SNARE associated Golgi protein
IA74_RS18150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IA74_RS18185	COG3023	N-Acetylmuramoyl-L-alanine amidase
IA74_RS18230	COG1216	Glycosyl transferase, family 2
IA74_RS18235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IA74_RS18240	COG0438	transferase activity, transferring glycosyl groups
IA74_RS18255	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IA74_RS18305	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IA74_RS18330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IA74_RS18335	COG0167	dihydroorotate dehydrogenase activity
IA74_RS18400	COG5002	protein histidine kinase activity
IA74_RS18415	COG2172	sigma factor antagonist activity
IA74_RS18440	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IA74_RS18465	COG0497	DNA recombination
IA74_RS18475	COG2176	DNA-directed DNA polymerase activity
IA74_RS18475	COG5002	protein histidine kinase activity
IA74_RS18480	COG0592	DNA-directed DNA polymerase activity
IA74_RS18495	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IA74_RS18495	COG0321	lipoyl(octanoyl) transferase activity
IA74_RS18510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA74_RS18520	COG0156	8-amino-7-oxononanoate synthase activity
IA74_RS18625	COG0019	diaminopimelate decarboxylase activity
IA74_RS18630	COG0527	aspartate kinase activity
IA74_RS18635	COG2884	Cell division ATP-binding protein ftsE
IA74_RS18640	COG0140	phosphoribosyl-ATP diphosphatase activity
IA74_RS18640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IA74_RS18645	COG0107	imidazoleglycerol-phosphate synthase activity
IA74_RS18650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IA74_RS18860	COG4804	nuclease activity
IA74_RS18880	COG3586	endonuclease activity
IA74_RS18915	COG1917	Cupin 2, conserved barrel domain protein
IA74_RS18915	COG4977	sequence-specific DNA binding
IA74_RS18925	COG0693	protein deglycase activity
IA74_RS18940	COG0494	nUDIX hydrolase
IA74_RS18945	COG1401	restriction endodeoxyribonuclease activity
IA74_RS18955	COG3326	Membrane
IA74_RS19055	COG0561	phosphatase activity
IA74_RS19060	COG4206	TonB-dependent receptor
IA74_RS19060	COG1629	transport
IA74_RS19120	COG0363	glucosamine-6-phosphate deaminase activity
IA74_RS19125	COG2365	Tyrosine phosphatase family
IA74_RS19160	COG1032	radical SAM domain protein
IA74_RS19165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IA74_RS19170	COG0463	Glycosyl transferase, family 2
IA74_RS19175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IA74_RS19180	COG0646	methionine synthase
IA74_RS19180	COG1410	methionine synthase
IA74_RS19220	COG1408	metallophosphoesterase
IA74_RS19225	COG1132	(ABC) transporter
IA74_RS19230	COG1132	(ABC) transporter
IA74_RS19245	COG0420	3'-5' exonuclease activity
IA74_RS19280	COG0681	Belongs to the peptidase S26 family
IA74_RS19450	COG3344	reverse transcriptase
IA74_RS19560	COG0551	DNA topoisomerase type I activity
IA74_RS19560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IA74_RS19640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IA74_RS19645	COG1120	ATPase activity
IA74_RS19650	COG2205	protein histidine kinase activity
IA74_RS19650	COG0784	Response regulator, receiver
IA74_RS19650	COG2198	Histidine kinase
IA74_RS19655	COG2204	response regulator
IA74_RS19685	COG0582	viral genome integration into host DNA
IA74_RS19770	COG0358	DNA primase activity
IA74_RS19895	COG2204	response regulator
IA74_RS19900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IA74_RS19900	COG0784	Response regulator, receiver
IA74_RS19900	COG2205	protein histidine kinase activity
IA74_RS19900	COG2198	Histidine kinase
IA74_RS19960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IA74_RS19960	COG0551	DNA topoisomerase type I activity
IA74_RS20000	COG4974	Belongs to the 'phage' integrase family
IA74_RS20035	COG0641	radical SAM
IA74_RS20040	COG3591	Belongs to the peptidase S1B family
IA74_RS20045	COG3591	Belongs to the peptidase S1B family
IA74_RS20080	COG1592	Rubrerythrin
IA74_RS20080	COG1773	rubredoxin
IA74_RS20090	COG3152	Membrane
IA74_RS20095	COG0339	signal peptide processing
IA74_RS20100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IA74_RS20100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IA74_RS20110	COG4206	TonB-dependent receptor
IA74_RS20110	COG1629	transport
IA74_RS20125	COG0131	Imidazoleglycerol-phosphate dehydratase
IA74_RS20125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IA74_RS20135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IA74_RS20140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IA74_RS20150	COG1741	Belongs to the pirin family
IA74_RS20155	COG4232	protein-disulfide reductase activity
IA74_RS20165	COG0572	uridine kinase
IA74_RS20170	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IA74_RS20175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IA74_RS20185	COG1410	methionine synthase
IA74_RS20185	COG0646	methionine synthase
IA74_RS20190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IA74_RS20225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IA74_RS20235	COG1295	ribonuclease BN
IA74_RS20245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IA74_RS20250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA74_RS20255	COG1216	Glycosyl transferase, family 2
IA74_RS20305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IA74_RS20315	COG1216	Glycosyl transferase, family 2
IA74_RS20315	COG1442	glycosyl transferase family 8
IA74_RS20320	COG0726	polysaccharide deacetylase
IA74_RS20370	COG5002	protein histidine kinase activity
IA74_RS20375	COG2205	protein histidine kinase activity
IA74_RS20375	COG2202	Pas domain
IA74_RS20380	COG0534	Mate efflux family protein
IA74_RS20385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IA74_RS20390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IA74_RS20395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IA74_RS20460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IA74_RS20500	COG2195	Cleaves the N-terminal amino acid of tripeptides
IA74_RS20510	COG0668	transmembrane transport
IA74_RS20515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IA74_RS20525	COG3250	beta-galactosidase activity
IA74_RS20530	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS20535	COG3119	arylsulfatase activity
IA74_RS20540	COG3119	arylsulfatase activity
IA74_RS20545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS20550	COG2205	protein histidine kinase activity
IA74_RS20550	COG0745	RESPONSE REGULATOR receiver
IA74_RS20550	COG3292	Two component regulator propeller
IA74_RS20555	COG1830	Aldolase
IA74_RS20560	COG0588	phosphoglycerate mutase activity
IA74_RS20570	COG1119	ATPase activity
IA74_RS20575	COG3119	arylsulfatase activity
IA74_RS20580	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS20590	COG1629	transport
IA74_RS20590	COG4206	TonB-dependent receptor
IA74_RS20605	COG1523	belongs to the glycosyl hydrolase 13 family
IA74_RS20610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IA74_RS20630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IA74_RS20645	COG0126	phosphoglycerate kinase activity
IA74_RS20660	COG2311	Membrane
IA74_RS20710	COG0424	maF-like protein
IA74_RS20715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IA74_RS20730	COG0778	Nitroreductase
IA74_RS20735	COG0288	reversible hydration of carbon dioxide
IA74_RS20750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IA74_RS20760	COG5016	pyruvate
IA74_RS20760	COG0511	ligase activity, forming carbon-carbon bonds
IA74_RS20765	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IA74_RS20780	COG0366	Alpha amylase catalytic
IA74_RS20800	COG0191	fructose-bisphosphate aldolase activity
IA74_RS20810	COG0254	rRNA binding
IA74_RS20820	COG5002	protein histidine kinase activity
IA74_RS20840	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IA74_RS20845	COG4206	TonB-dependent receptor
IA74_RS20845	COG1629	transport
IA74_RS20850	COG1609	Transcriptional regulator
IA74_RS20900	COG1554	hydrolase, family 65, central catalytic
IA74_RS20905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA74_RS20930	COG0047	phosphoribosylformylglycinamidine synthase activity
IA74_RS20930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IA74_RS20935	COG0745	RESPONSE REGULATOR receiver
IA74_RS20935	COG2205	protein histidine kinase activity
IA74_RS20935	COG3292	Two component regulator propeller
IA74_RS20950	COG1649	PFAM Uncharacterised BCR, COG1649
IA74_RS20970	COG1966	Carbon starvation protein
IA74_RS20980	COG1649	PFAM Uncharacterised BCR, COG1649
IA74_RS20985	COG2205	protein histidine kinase activity
IA74_RS20985	COG4999	Histidine kinase
IA74_RS20985	COG3850	Histidine kinase
IA74_RS20985	COG3437	response regulator, receiver
IA74_RS21030	COG2113	Glycine betaine
IA74_RS21035	COG4176	ABC-type proline glycine betaine transport system permease component
IA74_RS21050	COG0745	RESPONSE REGULATOR receiver
IA74_RS21050	COG2205	protein histidine kinase activity
IA74_RS21050	COG3292	Two component regulator propeller
IA74_RS21055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IA74_RS21055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IA74_RS21065	COG1621	beta-fructofuranosidase activity
IA74_RS21100	COG4804	nuclease activity
IA74_RS21145	COG1752	Esterase of the alpha-beta hydrolase superfamily
IA74_RS21150	COG0475	glutathione-regulated potassium exporter activity
IA74_RS21175	COG3015	lipoprotein NlpE involved in copper resistance
IA74_RS21185	COG3279	Response regulator of the LytR AlgR family
IA74_RS21200	COG4948	Mandelate Racemase Muconate Lactonizing
IA74_RS21205	COG1629	transport
IA74_RS21205	COG4206	TonB-dependent receptor
IA74_RS21210	COG0702	epimerase
IA74_RS21230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IA74_RS21250	COG0484	heat shock protein binding
IA74_RS21255	COG2205	protein histidine kinase activity
IA74_RS21255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IA74_RS21260	COG2194	sulfuric ester hydrolase activity
IA74_RS21310	COG0028	Belongs to the TPP enzyme family
IA74_RS21325	COG0459	protein refolding
IA74_RS21330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IA74_RS21370	COG2326	polyphosphate kinase activity
IA74_RS21420	COG3537	Alpha-1,2-mannosidase
IA74_RS21425	COG1506	peptidase
IA74_RS21425	COG0823	Involved in the tonB-independent uptake of proteins
IA74_RS21455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IA74_RS21490	COG0514	ATP-dependent DNA helicase (RecQ)
IA74_RS21505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IA74_RS21515	COG0671	phosphoesterase, PA-phosphatase related
IA74_RS21520	COG0702	epimerase
IA74_RS21525	COG4206	TonB-dependent receptor
IA74_RS21525	COG1629	transport
IA74_RS21555	COG0463	Glycosyl transferase, family 2
IA74_RS21570	COG0066	3-isopropylmalate dehydratase activity
IA74_RS21575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IA74_RS21580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IA74_RS21630	COG0616	signal peptide processing
IA74_RS21635	COG1663	tetraacyldisaccharide 4'-kinase activity
IA74_RS21640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IA74_RS21645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IA74_RS21655	COG4974	Belongs to the 'phage' integrase family
IA74_RS21730	COG2207	Transcriptional regulator
IA74_RS21730	COG3708	Transcriptional regulator
IA74_RS21800	COG0776	regulation of translation
IA74_RS21895	COG1917	Cupin 2, conserved barrel domain protein
IA74_RS21895	COG2207	Transcriptional regulator
IA74_RS21905	COG1028	Short-chain dehydrogenase reductase Sdr
IA74_RS21925	COG0463	Glycosyl transferase, family 2
IA74_RS21940	COG1971	Probably functions as a manganese efflux pump
IA74_RS21945	COG1477	protein flavinylation
IA74_RS21955	COG0037	tRNA processing
IA74_RS21970	COG4864	UPF0365 protein
IA74_RS21980	COG2176	DNA-directed DNA polymerase activity
IA74_RS21985	COG2910	NAD(P)H-binding
IA74_RS21990	COG0784	Response regulator, receiver
IA74_RS21990	COG2198	Histidine kinase
IA74_RS21990	COG2205	protein histidine kinase activity
IA74_RS21995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IA74_RS22005	COG4974	Belongs to the 'phage' integrase family
IA74_RS22045	COG0582	viral genome integration into host DNA
IA74_RS22070	COG3645	SOS response
IA74_RS22085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IA74_RS22125	COG1028	Short-chain dehydrogenase reductase Sdr
IA74_RS22140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IA74_RS22145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IA74_RS22150	COG4651	solute:proton antiporter activity
IA74_RS22150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IA74_RS22155	COG0439	Biotin carboxylase
IA74_RS22160	COG0511	ligase activity, forming carbon-carbon bonds
IA74_RS22165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IA74_RS22170	COG1917	Cupin 2, conserved barrel domain protein
IA74_RS22170	COG4977	sequence-specific DNA binding
IA74_RS22180	COG1335	isochorismatase
IA74_RS22190	COG5002	protein histidine kinase activity
IA74_RS22190	COG0784	Response regulator, receiver
IA74_RS22190	COG2205	protein histidine kinase activity
IA74_RS22195	COG2207	Transcriptional regulator
IA74_RS22200	COG0517	IMP dehydrogenase activity
IA74_RS22200	COG0516	GMP reductase activity
IA74_RS22235	COG2873	o-acetylhomoserine
IA74_RS22280	COG2076	Multidrug Resistance protein
IA74_RS22320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IA74_RS22330	COG1388	LysM domain
IA74_RS22330	COG0741	lytic transglycosylase activity
IA74_RS22335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IA74_RS22340	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IA74_RS22340	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IA74_RS22350	COG1285	pathogenesis
IA74_RS22370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IA74_RS22370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IA74_RS22385	COG1115	amino acid carrier protein
IA74_RS22395	COG1509	lysine 2,3-aminomutase activity
IA74_RS22400	COG2233	PERMEase
IA74_RS22415	COG1393	Belongs to the ArsC family
IA74_RS22425	COG1629	transport
IA74_RS22435	COG2304	oxidoreductase activity
IA74_RS22445	COG0351	phosphomethylpyrimidine kinase
IA74_RS22455	COG1139	Iron-sulfur cluster binding protein
IA74_RS22460	COG0247	lactate metabolic process
IA74_RS22465	COG0602	queuosine metabolic process
IA74_RS22475	COG2832	Protein of unknown function (DUF454)
IA74_RS22480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IA74_RS22495	COG3142	Participates in the control of copper homeostasis
IA74_RS22500	COG1418	mRNA catabolic process
IA74_RS22525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IA74_RS22540	COG4771	TonB-dependent receptor
IA74_RS22580	COG3340	Belongs to the peptidase S51 family
IA74_RS22585	COG2378	regulation of single-species biofilm formation
IA74_RS22665	COG0517	IMP dehydrogenase activity
IA74_RS22665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IA74_RS22665	COG0617	tRNA 3'-terminal CCA addition
IA74_RS22675	COG1126	abc transporter atp-binding protein
IA74_RS22685	COG1278	Cold shock
IA74_RS22725	COG0438	transferase activity, transferring glycosyl groups
IA74_RS22735	COG0463	Glycosyl transferase, family 2
IA74_RS22735	COG1216	Glycosyl transferase, family 2
IA74_RS22740	COG1216	Glycosyl transferase, family 2
IA74_RS22770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IA74_RS22810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IA74_RS22830	COG0632	four-way junction helicase activity
IA74_RS22835	COG0673	inositol 2-dehydrogenase activity
IA74_RS22840	COG1272	protein, Hemolysin III
IA74_RS22845	COG1328	CTP reductase activity
IA74_RS22845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IA74_RS22855	COG2814	Major facilitator Superfamily
IA74_RS22865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IA74_RS22875	COG0750	zinc metalloprotease
IA74_RS22880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IA74_RS22890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IA74_RS22895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IA74_RS22905	COG1214	PFAM Peptidase M22, glycoprotease
IA74_RS22910	COG2205	protein histidine kinase activity
IA74_RS22910	COG2198	Histidine kinase
IA74_RS22910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IA74_RS22910	COG0784	Response regulator, receiver
IA74_RS22930	COG0194	GDP metabolic process
IA74_RS22935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IA74_RS22940	COG1408	metallophosphoesterase
IA74_RS22945	COG1575	Belongs to the MenA family. Type 1 subfamily
IA74_RS22950	COG1088	dTDP-glucose 4,6-dehydratase activity
IA74_RS22955	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IA74_RS22965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IA74_RS22975	COG2204	response regulator
IA74_RS22980	COG0488	(ABC) transporter
IA74_RS23015	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IA74_RS23015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IA74_RS23040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IA74_RS23045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IA74_RS23055	COG1522	sequence-specific DNA binding
IA74_RS23080	COG0811	peptide transport
IA74_RS23090	COG0084	hydrolase, TatD family'
IA74_RS23105	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IA74_RS23110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IA74_RS23115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IA74_RS23120	COG0205	6-phosphofructokinase activity
IA74_RS23140	COG0372	Belongs to the citrate synthase family
IA74_RS23145	COG0538	isocitrate dehydrogenase activity
IA74_RS23155	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IA74_RS23165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IA74_RS23190	COG0129	dihydroxy-acid dehydratase activity
IA74_RS23210	COG2885	chlorophyll binding
IA74_RS23230	COG3681	Belongs to the UPF0597 family
IA74_RS23265	COG3119	arylsulfatase activity
IA74_RS23285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IA74_RS23295	COG0702	epimerase
IA74_RS23300	COG4771	TonB-dependent receptor
IA74_RS23315	COG0702	epimerase
IA74_RS23320	COG4206	TonB-dependent receptor
IA74_RS23320	COG1629	transport
IA74_RS23340	COG4771	TonB-dependent receptor
IA74_RS23370	COG1012	belongs to the aldehyde dehydrogenase family
IA74_RS23395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IA74_RS23395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IA74_RS23400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IA74_RS23430	COG2205	protein histidine kinase activity
IA74_RS23430	COG0784	Response regulator, receiver
IA74_RS23430	COG2198	Histidine kinase
IA74_RS23445	COG1752	Esterase of the alpha-beta hydrolase superfamily
IA74_RS23455	COG4974	Belongs to the 'phage' integrase family
IA74_RS23495	COG0551	DNA topoisomerase type I activity
IA74_RS23495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IA74_RS23555	COG0784	Response regulator, receiver
IA74_RS23555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IA74_RS23555	COG2198	Histidine kinase
IA74_RS23555	COG2205	protein histidine kinase activity
IA74_RS23560	COG2204	response regulator
IA74_RS23685	COG0358	DNA primase activity
IA74_RS23760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IA74_RS23765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IA74_RS23770	COG0166	Belongs to the GPI family
IA74_RS23780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IA74_RS23790	COG2502	aspartate--ammonia ligase
IA74_RS23795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IA74_RS23810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IA74_RS23835	COG0860	N-Acetylmuramoyl-L-alanine amidase
IA74_RS23870	COG0776	regulation of translation