locus-tag	class	description
IB64_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IB64_RS00020	COG1640	4-alpha-glucanotransferase
IB64_RS00030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IB64_RS00035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IB64_RS00065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IB64_RS00070	COG1022	Amp-dependent synthetase and ligase
IB64_RS00085	COG0359	binds to the 23S rRNA
IB64_RS00090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IB64_RS00095	COG0360	Binds together with S18 to 16S ribosomal RNA
IB64_RS00115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IB64_RS00145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IB64_RS00165	COG4771	TonB-dependent receptor
IB64_RS00180	COG2431	L-lysine efflux transmembrane transporter activity
IB64_RS00215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IB64_RS00220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IB64_RS00225	COG0386	Belongs to the glutathione peroxidase family
IB64_RS00245	COG3275	phosphorelay sensor kinase activity
IB64_RS00250	COG3279	Response regulator of the LytR AlgR family
IB64_RS00260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IB64_RS00270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IB64_RS00285	COG3250	beta-galactosidase activity
IB64_RS00290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IB64_RS00300	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IB64_RS00305	COG0658	competence protein
IB64_RS00310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IB64_RS00315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IB64_RS00325	COG0009	L-threonylcarbamoyladenylate synthase
IB64_RS00350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IB64_RS00355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS00370	COG0438	transferase activity, transferring glycosyl groups
IB64_RS00410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS00420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IB64_RS00425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IB64_RS00480	COG0519	Catalyzes the synthesis of GMP from XMP
IB64_RS00495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IB64_RS00495	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IB64_RS00500	COG0514	ATP-dependent DNA helicase (RecQ)
IB64_RS00525	COG0436	Aminotransferase
IB64_RS00530	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IB64_RS00545	COG0358	DNA primase activity
IB64_RS00550	COG3119	arylsulfatase activity
IB64_RS00555	COG0702	epimerase
IB64_RS00560	COG4206	TonB-dependent receptor
IB64_RS00560	COG1629	transport
IB64_RS00575	COG0302	gtp cyclohydrolase
IB64_RS00585	COG0149	triose-phosphate isomerase activity
IB64_RS00600	COG0739	heme binding
IB64_RS00605	COG0105	UTP biosynthetic process
IB64_RS00610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IB64_RS00635	COG0811	peptide transport
IB64_RS00645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IB64_RS00695	COG1629	transport
IB64_RS00725	COG4946	Tricorn protease homolog
IB64_RS00725	COG1506	peptidase
IB64_RS00725	COG0823	Involved in the tonB-independent uptake of proteins
IB64_RS00730	COG0039	L-malate dehydrogenase activity
IB64_RS00780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IB64_RS00795	COG4948	Mandelate Racemase Muconate Lactonizing
IB64_RS00820	COG3118	belongs to the thioredoxin family
IB64_RS00825	COG0489	protein tyrosine kinase activity
IB64_RS00840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IB64_RS00850	COG1570	exodeoxyribonuclease VII activity
IB64_RS00860	COG0482	sulfurtransferase activity
IB64_RS00880	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IB64_RS00885	COG0179	Fumarylacetoacetate (FAA) hydrolase
IB64_RS00890	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IB64_RS00900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IB64_RS00905	COG0052	Belongs to the universal ribosomal protein uS2 family
IB64_RS00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IB64_RS00915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IB64_RS00930	COG0017	Asparaginyl-tRNA synthetase
IB64_RS00935	COG1187	pseudouridine synthase activity
IB64_RS00975	COG0110	maltose O-acetyltransferase activity
IB64_RS00980	COG3022	response to hydroperoxide
IB64_RS00985	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS01045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IB64_RS01085	COG1216	Glycosyl transferase, family 2
IB64_RS01110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IB64_RS01140	COG0297	glycogen (starch) synthase activity
IB64_RS01165	COG0745	RESPONSE REGULATOR receiver
IB64_RS01230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IB64_RS01245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IB64_RS01260	COG0516	GMP reductase activity
IB64_RS01260	COG0517	IMP dehydrogenase activity
IB64_RS01265	COG0514	ATP-dependent DNA helicase (RecQ)
IB64_RS01270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IB64_RS01280	COG0544	peptidyl-prolyl cis-trans isomerase activity
IB64_RS01285	COG0724	RNA recognition motif
IB64_RS01295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IB64_RS01300	COG1127	ABC transporter
IB64_RS01305	COG0745	RESPONSE REGULATOR receiver
IB64_RS01310	COG1160	GTP binding
IB64_RS01315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IB64_RS01320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IB64_RS01365	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IB64_RS01370	COG0470	DNA polymerase III
IB64_RS01375	COG1774	PSP1 C-terminal conserved region
IB64_RS01385	COG0772	Belongs to the SEDS family
IB64_RS01400	COG1792	Involved in formation and maintenance of cell shape
IB64_RS01410	COG0138	bifunctional purine biosynthesis protein purh
IB64_RS01415	COG3590	peptidase
IB64_RS01420	COG0488	(ABC) transporter
IB64_RS01445	COG0784	Response regulator, receiver
IB64_RS01445	COG2205	protein histidine kinase activity
IB64_RS01450	COG0534	Mate efflux family protein
IB64_RS01455	COG0612	Peptidase, M16
IB64_RS01460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IB64_RS01475	COG0564	pseudouridine synthase activity
IB64_RS01515	COG1131	(ABC) transporter
IB64_RS01645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IB64_RS01650	COG1120	ATPase activity
IB64_RS01680	COG1192	Involved in chromosome partitioning
IB64_RS01685	COG1629	transport
IB64_RS01765	COG4974	Belongs to the 'phage' integrase family
IB64_RS01790	COG1696	Membrane protein involved in D-alanine export
IB64_RS01825	COG1309	transcriptional regulator
IB64_RS01830	COG2986	histidine ammonia-lyase
IB64_RS01840	COG1228	amidohydrolase
IB64_RS01850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IB64_RS01865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IB64_RS01880	COG0203	ribosomal protein L17
IB64_RS01885	COG0202	RNA polymerase activity
IB64_RS01890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IB64_RS01895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IB64_RS01900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IB64_RS01905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IB64_RS01910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IB64_RS01925	COG0200	Binds to the 23S rRNA
IB64_RS01930	COG1841	ribosomal large subunit assembly
IB64_RS01935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IB64_RS01940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IB64_RS01945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IB64_RS01950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IB64_RS01955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IB64_RS01960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IB64_RS01965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IB64_RS01970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IB64_RS01975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IB64_RS01980	COG0255	Belongs to the universal ribosomal protein uL29 family
IB64_RS01985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IB64_RS01990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IB64_RS01995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IB64_RS02000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IB64_RS02005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IB64_RS02010	COG0089	rRNA binding
IB64_RS02015	COG0088	Forms part of the polypeptide exit tunnel
IB64_RS02020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IB64_RS02025	COG0051	transcription antitermination factor activity, RNA binding
IB64_RS02030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IB64_RS02035	COG0049	tRNA binding
IB64_RS02040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IB64_RS02070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IB64_RS02075	COG0085	RNA polymerase activity
IB64_RS02080	COG0222	ribosome binding
IB64_RS02085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IB64_RS02090	COG0081	regulation of translation
IB64_RS02095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IB64_RS02140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IB64_RS02145	COG4974	Belongs to the 'phage' integrase family
IB64_RS02150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IB64_RS02155	COG0006	proline dipeptidase activity
IB64_RS02160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IB64_RS02170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IB64_RS02175	COG1480	7TM receptor with intracellular HD hydrolase
IB64_RS02180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IB64_RS02190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IB64_RS02205	COG1027	Aspartate ammonia-lyase
IB64_RS02210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IB64_RS02215	COG0252	asparaginase activity
IB64_RS02230	COG2096	Adenosyltransferase
IB64_RS02265	COG0657	acetylesterase activity
IB64_RS02265	COG2755	lipolytic protein G-D-S-L family
IB64_RS02280	COG3279	Response regulator of the LytR AlgR family
IB64_RS02295	COG4771	TonB-dependent receptor
IB64_RS02335	COG0702	epimerase
IB64_RS02345	COG4977	sequence-specific DNA binding
IB64_RS02345	COG1917	Cupin 2, conserved barrel domain protein
IB64_RS02360	COG2197	response regulator
IB64_RS02365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IB64_RS02370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IB64_RS02395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IB64_RS02405	COG1185	polyribonucleotide nucleotidyltransferase activity
IB64_RS02420	COG4771	TonB-dependent receptor
IB64_RS02445	COG3426	butyrate kinase activity
IB64_RS02450	COG0280	phosphate acetyltransferase
IB64_RS02460	COG1619	proteins homologs of microcin C7 resistance protein MccF
IB64_RS02465	COG2234	aminopeptidase activity
IB64_RS02470	COG2166	iron-sulfur cluster assembly
IB64_RS02475	COG3655	Transcriptional regulator
IB64_RS02485	COG1266	CAAX protease self-immunity
IB64_RS02490	COG0196	riboflavin kinase activity
IB64_RS02495	COG1011	Hydrolase
IB64_RS02500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IB64_RS02505	COG0784	Response regulator, receiver
IB64_RS02505	COG5002	protein histidine kinase activity
IB64_RS02510	COG1773	rubredoxin
IB64_RS02515	COG1283	sodium-dependent phosphate transmembrane transporter activity
IB64_RS02525	COG2205	protein histidine kinase activity
IB64_RS02550	COG0006	proline dipeptidase activity
IB64_RS02565	COG0509	glycine decarboxylation via glycine cleavage system
IB64_RS02570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IB64_RS02600	COG0702	epimerase
IB64_RS02605	COG4771	TonB-dependent receptor
IB64_RS02620	COG0793	Belongs to the peptidase S41A family
IB64_RS02625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IB64_RS02665	COG4771	TonB-dependent receptor
IB64_RS02670	COG3292	Two component regulator propeller
IB64_RS02670	COG0745	RESPONSE REGULATOR receiver
IB64_RS02670	COG2205	protein histidine kinase activity
IB64_RS02675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IB64_RS02685	COG2814	Major facilitator Superfamily
IB64_RS02685	COG0477	Major facilitator Superfamily
IB64_RS02710	COG0483	inositol monophosphate 1-phosphatase activity
IB64_RS02720	COG3345	alpha-galactosidase
IB64_RS02745	COG3475	LICD family
IB64_RS02750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IB64_RS02780	COG0438	transferase activity, transferring glycosyl groups
IB64_RS02830	COG0776	regulation of translation
IB64_RS02835	COG1970	mechanosensitive ion channel activity
IB64_RS02860	COG4771	TonB-dependent receptor
IB64_RS02880	COG2205	protein histidine kinase activity
IB64_RS02880	COG0745	RESPONSE REGULATOR receiver
IB64_RS02880	COG3292	Two component regulator propeller
IB64_RS02910	COG2816	NAD+ diphosphatase activity
IB64_RS02965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IB64_RS02970	COG0776	regulation of translation
IB64_RS03005	COG2207	Transcriptional regulator
IB64_RS03005	COG1609	Transcriptional regulator
IB64_RS03020	COG0674	pyruvate-flavodoxin oxidoreductase activity
IB64_RS03020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IB64_RS03025	COG1013	pyruvate-flavodoxin oxidoreductase activity
IB64_RS03030	COG0584	glycerophosphoryl diester phosphodiesterase
IB64_RS03035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IB64_RS03040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IB64_RS03045	COG4206	TonB-dependent receptor
IB64_RS03045	COG1629	transport
IB64_RS03060	COG1629	transport
IB64_RS03095	COG1629	transport
IB64_RS03110	COG1217	gtp-binding protein TYPA
IB64_RS03115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IB64_RS03130	COG0318	PFAM AMP-dependent synthetase and ligase
IB64_RS03135	COG5002	protein histidine kinase activity
IB64_RS03135	COG2205	protein histidine kinase activity
IB64_RS03135	COG0784	Response regulator, receiver
IB64_RS03155	COG3119	arylsulfatase activity
IB64_RS03165	COG1629	transport
IB64_RS03165	COG4206	TonB-dependent receptor
IB64_RS03185	COG4591	ABC-type transport system involved in lipoprotein release permease component
IB64_RS03190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IB64_RS03205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IB64_RS03210	COG4974	Belongs to the 'phage' integrase family
IB64_RS03225	COG0606	chelatase, subunit chli
IB64_RS03325	COG0438	transferase activity, transferring glycosyl groups
IB64_RS03350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IB64_RS03355	COG0438	transferase activity, transferring glycosyl groups
IB64_RS03365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IB64_RS03370	COG0545	Peptidyl-prolyl cis-trans isomerase
IB64_RS03375	COG0545	Peptidyl-prolyl cis-trans isomerase
IB64_RS03380	COG1522	sequence-specific DNA binding
IB64_RS03400	COG3275	phosphorelay sensor kinase activity
IB64_RS03415	COG1566	PFAM secretion protein HlyD family protein
IB64_RS03480	COG4206	TonB-dependent receptor
IB64_RS03480	COG1629	transport
IB64_RS03490	COG2814	Major facilitator Superfamily
IB64_RS03520	COG2205	protein histidine kinase activity
IB64_RS03520	COG0745	RESPONSE REGULATOR receiver
IB64_RS03520	COG3292	Two component regulator propeller
IB64_RS03525	COG1621	beta-fructofuranosidase activity
IB64_RS03585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IB64_RS03590	COG3409	Peptidoglycan-binding domain 1 protein
IB64_RS03590	COG0793	Belongs to the peptidase S41A family
IB64_RS03615	COG1053	succinate dehydrogenase
IB64_RS03620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IB64_RS03635	COG4771	TonB-dependent receptor
IB64_RS03660	COG0758	DNA mediated transformation
IB64_RS03660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IB64_RS03670	COG0826	peptidase U32
IB64_RS03680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IB64_RS03695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IB64_RS03700	COG0557	exoribonuclease II activity
IB64_RS03725	COG1595	DNA-templated transcription, initiation
IB64_RS03745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IB64_RS03760	COG0012	GTP binding
IB64_RS03765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IB64_RS03770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IB64_RS03780	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IB64_RS03790	COG0495	leucyl-tRNA aminoacylation
IB64_RS03795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IB64_RS03820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IB64_RS03840	COG0731	radical SAM domain protein
IB64_RS03840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IB64_RS03865	COG0659	secondary active sulfate transmembrane transporter activity
IB64_RS03870	COG1592	Rubrerythrin
IB64_RS03875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IB64_RS03895	COG0427	acetyl-CoA hydrolase
IB64_RS03905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IB64_RS03915	COG3250	beta-galactosidase activity
IB64_RS04025	COG2177	Part of the ABC transporter FtsEX involved in
IB64_RS04035	COG1968	undecaprenyl-diphosphatase activity
IB64_RS04040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IB64_RS04045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IB64_RS04050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IB64_RS04060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IB64_RS04065	COG1611	Belongs to the LOG family
IB64_RS04080	COG0594	ribonuclease P activity
IB64_RS04085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IB64_RS04100	COG0823	Involved in the tonB-independent uptake of proteins
IB64_RS04100	COG1506	peptidase
IB64_RS04100	COG4946	Tricorn protease homolog
IB64_RS04110	COG3119	arylsulfatase activity
IB64_RS04115	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IB64_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
IB64_RS04125	COG4677	pectinesterase activity
IB64_RS04130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IB64_RS04170	COG1121	(ABC) transporter
IB64_RS04180	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IB64_RS04180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IB64_RS04200	COG0823	Involved in the tonB-independent uptake of proteins
IB64_RS04200	COG1506	peptidase
IB64_RS04205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IB64_RS04205	COG0116	Belongs to the methyltransferase superfamily
IB64_RS04210	COG1045	serine acetyltransferase
IB64_RS04215	COG3275	phosphorelay sensor kinase activity
IB64_RS04220	COG3279	Response regulator of the LytR AlgR family
IB64_RS04230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IB64_RS04230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IB64_RS04250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IB64_RS04255	COG1694	Mazg nucleotide pyrophosphohydrolase
IB64_RS04265	COG0322	excinuclease ABC activity
IB64_RS04270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IB64_RS04315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IB64_RS04320	COG2715	membrane protein required for spore maturation
IB64_RS04330	COG2255	four-way junction helicase activity
IB64_RS04345	COG3591	Belongs to the peptidase S1B family
IB64_RS04355	COG0513	Belongs to the DEAD box helicase family
IB64_RS04365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IB64_RS04380	COG0612	Peptidase, M16
IB64_RS04400	COG1312	Catalyzes the dehydration of D-mannonate
IB64_RS04405	COG1028	Short-chain dehydrogenase reductase Sdr
IB64_RS04420	COG0681	Belongs to the peptidase S26 family
IB64_RS04430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IB64_RS04460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IB64_RS04475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IB64_RS04480	COG3250	beta-galactosidase activity
IB64_RS04500	COG0215	cysteine-tRNA ligase activity
IB64_RS04510	COG0561	phosphatase activity
IB64_RS04570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IB64_RS04585	COG0205	6-phosphofructokinase activity
IB64_RS04595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IB64_RS04600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IB64_RS04605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IB64_RS04610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IB64_RS04620	COG1216	Glycosyl transferase, family 2
IB64_RS04640	COG1442	glycosyl transferase family 8
IB64_RS04645	COG1442	glycosyl transferase family 8
IB64_RS04645	COG1216	Glycosyl transferase, family 2
IB64_RS04655	COG1442	glycosyl transferase family 8
IB64_RS04655	COG1216	Glycosyl transferase, family 2
IB64_RS04660	COG1132	(ABC) transporter
IB64_RS04665	COG0328	RNA-DNA hybrid ribonuclease activity
IB64_RS04665	COG3341	Caulimovirus viroplasmin
IB64_RS04675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IB64_RS04685	COG0326	Molecular chaperone. Has ATPase activity
IB64_RS04695	COG1166	arginine decarboxylase activity
IB64_RS04700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IB64_RS04705	COG1595	DNA-templated transcription, initiation
IB64_RS04750	COG1454	alcohol dehydrogenase
IB64_RS04755	COG0235	Class ii aldolase
IB64_RS04760	COG1070	Carbohydrate kinase
IB64_RS04765	COG0738	Major facilitator superfamily
IB64_RS04785	COG0779	Required for maturation of 30S ribosomal subunits
IB64_RS04790	COG0195	Participates in both transcription termination and antitermination
IB64_RS04795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IB64_RS04805	COG0719	Fe-S assembly protein
IB64_RS04815	COG0396	ATPase activity
IB64_RS04820	COG0719	Fe-S assembly protein
IB64_RS04825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IB64_RS04830	COG0393	Putative heavy-metal-binding
IB64_RS04835	COG3345	alpha-galactosidase
IB64_RS04845	COG4771	TonB-dependent receptor
IB64_RS04870	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IB64_RS04875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IB64_RS04900	COG0187	DNA topoisomerase II activity
IB64_RS04905	COG0268	Binds directly to 16S ribosomal RNA
IB64_RS04915	COG1381	Involved in DNA repair and RecF pathway recombination
IB64_RS04920	COG1610	YqeY-like protein
IB64_RS04925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IB64_RS04940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IB64_RS04945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IB64_RS04950	COG0772	Belongs to the SEDS family
IB64_RS04955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IB64_RS04960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IB64_RS04965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IB64_RS04980	COG0275	rRNA processing
IB64_RS05005	COG4771	TonB-dependent receptor
IB64_RS05035	COG0756	dUTP diphosphatase activity
IB64_RS05050	COG4942	peptidase
IB64_RS05055	COG2205	protein histidine kinase activity
IB64_RS05055	COG3292	Two component regulator propeller
IB64_RS05055	COG0745	RESPONSE REGULATOR receiver
IB64_RS05060	COG3940	Belongs to the glycosyl hydrolase 43 family
IB64_RS05070	COG3250	beta-galactosidase activity
IB64_RS05100	COG0383	alpha-mannosidase activity
IB64_RS05105	COG4206	TonB-dependent receptor
IB64_RS05105	COG1629	transport
IB64_RS05125	COG3507	Belongs to the glycosyl hydrolase 43 family
IB64_RS05145	COG3537	Alpha-1,2-mannosidase
IB64_RS05155	COG2017	converts alpha-aldose to the beta-anomer
IB64_RS05215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IB64_RS05220	COG1022	Amp-dependent synthetase and ligase
IB64_RS05235	COG2954	triphosphatase activity
IB64_RS05255	COG3250	beta-galactosidase activity
IB64_RS05260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS05265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IB64_RS05270	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IB64_RS05290	COG1629	transport
IB64_RS05290	COG4206	TonB-dependent receptor
IB64_RS05295	COG2205	protein histidine kinase activity
IB64_RS05295	COG3292	Two component regulator propeller
IB64_RS05295	COG0745	RESPONSE REGULATOR receiver
IB64_RS05300	COG2205	protein histidine kinase activity
IB64_RS05300	COG3292	Two component regulator propeller
IB64_RS05300	COG0745	RESPONSE REGULATOR receiver
IB64_RS05325	COG4771	TonB-dependent receptor
IB64_RS05390	COG0673	inositol 2-dehydrogenase activity
IB64_RS05405	COG4771	TonB-dependent receptor
IB64_RS05430	COG0423	glycine-tRNA ligase activity
IB64_RS05435	COG0545	Peptidyl-prolyl cis-trans isomerase
IB64_RS05445	COG3005	denitrification pathway
IB64_RS05450	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IB64_RS05460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IB64_RS05480	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IB64_RS05500	COG3876	Protein conserved in bacteria
IB64_RS05520	COG0463	Glycosyl transferase, family 2
IB64_RS05520	COG1216	Glycosyl transferase, family 2
IB64_RS05535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IB64_RS05540	COG3876	Protein conserved in bacteria
IB64_RS05550	COG1629	transport
IB64_RS05550	COG4206	TonB-dependent receptor
IB64_RS05560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IB64_RS05565	COG0475	glutathione-regulated potassium exporter activity
IB64_RS05565	COG0589	response to stress
IB64_RS05570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IB64_RS05585	COG0733	neurotransmitter:sodium symporter activity
IB64_RS05595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IB64_RS05610	COG0076	glutamate decarboxylase activity
IB64_RS05615	COG2066	Belongs to the glutaminase family
IB64_RS05620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IB64_RS05620	COG2205	protein histidine kinase activity
IB64_RS05625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IB64_RS05630	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IB64_RS05750	COG1346	cytolysis
IB64_RS05775	COG0280	phosphate acetyltransferase
IB64_RS05780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IB64_RS05785	COG1785	Belongs to the alkaline phosphatase family
IB64_RS05795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IB64_RS05800	COG2003	Belongs to the UPF0758 family
IB64_RS05805	COG0463	Glycosyl transferase, family 2
IB64_RS05805	COG1216	Glycosyl transferase, family 2
IB64_RS05810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IB64_RS05815	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IB64_RS05820	COG0515	serine threonine protein kinase
IB64_RS05820	COG2815	serine threonine protein kinase
IB64_RS05825	COG0564	pseudouridine synthase activity
IB64_RS05880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IB64_RS05885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IB64_RS05895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IB64_RS05915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IB64_RS05925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IB64_RS05925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IB64_RS05930	COG2890	protein-(glutamine-N5) methyltransferase activity
IB64_RS05935	COG2137	regulation of response to DNA damage stimulus
IB64_RS05940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IB64_RS05965	COG1929	Belongs to the glycerate kinase type-1 family
IB64_RS05975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IB64_RS05980	COG1396	sequence-specific DNA binding
IB64_RS05980	COG1917	Cupin 2, conserved barrel domain protein
IB64_RS05985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IB64_RS05990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IB64_RS05995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IB64_RS06000	COG0137	argininosuccinate synthase activity
IB64_RS06025	COG0531	amino acid
IB64_RS06035	COG0039	L-malate dehydrogenase activity
IB64_RS06040	COG2996	Protein conserved in bacteria
IB64_RS06065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IB64_RS06070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IB64_RS06095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IB64_RS06100	COG1136	(ABC) transporter
IB64_RS06100	COG0577	efflux transmembrane transporter activity
IB64_RS06105	COG1136	(ABC) transporter
IB64_RS06105	COG0577	efflux transmembrane transporter activity
IB64_RS06110	COG1136	(ABC) transporter
IB64_RS06115	COG1940	carbohydrate kinase activity
IB64_RS06120	COG0335	large ribosomal subunit rRNA binding
IB64_RS06125	COG0737	Belongs to the 5'-nucleotidase family
IB64_RS06130	COG0737	Belongs to the 5'-nucleotidase family
IB64_RS06135	COG1472	Belongs to the glycosyl hydrolase 3 family
IB64_RS06140	COG1472	Belongs to the glycosyl hydrolase 3 family
IB64_RS06145	COG1629	transport
IB64_RS06145	COG4206	TonB-dependent receptor
IB64_RS06155	COG3119	arylsulfatase activity
IB64_RS06180	COG0446	pyridine nucleotide-disulphide oxidoreductase
IB64_RS06195	COG2204	response regulator
IB64_RS06205	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IB64_RS06225	COG2205	protein histidine kinase activity
IB64_RS06230	COG5002	protein histidine kinase activity
IB64_RS06245	COG4771	TonB-dependent receptor
IB64_RS06280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IB64_RS06280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IB64_RS06285	COG0436	Aminotransferase
IB64_RS06300	COG0826	peptidase U32
IB64_RS06315	COG4771	TonB-dependent receptor
IB64_RS06325	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IB64_RS06335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IB64_RS06345	COG3206	protein involved in exopolysaccharide biosynthesis
IB64_RS06345	COG0489	protein tyrosine kinase activity
IB64_RS06355	COG0460	homoserine dehydrogenase
IB64_RS06355	COG0527	aspartate kinase activity
IB64_RS06360	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
IB64_RS06415	COG4771	TonB-dependent receptor
IB64_RS06420	COG0702	epimerase
IB64_RS06430	COG3250	beta-galactosidase activity
IB64_RS06440	COG3250	beta-galactosidase activity
IB64_RS06445	COG3507	Belongs to the glycosyl hydrolase 43 family
IB64_RS06460	COG4771	TonB-dependent receptor
IB64_RS06475	COG2226	methyltransferase
IB64_RS06525	COG4974	Belongs to the 'phage' integrase family
IB64_RS06580	COG4974	Belongs to the 'phage' integrase family
IB64_RS06640	COG0202	RNA polymerase activity
IB64_RS06735	COG4974	Belongs to the 'phage' integrase family
IB64_RS06740	COG4974	Belongs to the 'phage' integrase family
IB64_RS06870	COG1475	DNA binding
IB64_RS06890	COG1192	Involved in chromosome partitioning
IB64_RS06910	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IB64_RS06925	COG0629	single-stranded DNA binding
IB64_RS06985	COG2197	response regulator
IB64_RS06990	COG1196	nuclear chromosome segregation
IB64_RS06990	COG0741	lytic transglycosylase activity
IB64_RS06990	COG0739	heme binding
IB64_RS07055	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IB64_RS07060	COG1388	LysM domain
IB64_RS07060	COG1705	Flagellar rod assembly protein muramidase FlgJ
IB64_RS07175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS07235	COG2755	lipolytic protein G-D-S-L family
IB64_RS07235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IB64_RS07295	COG0534	Mate efflux family protein
IB64_RS07300	COG0776	regulation of translation
IB64_RS07385	COG0546	phosphoglycolate phosphatase activity
IB64_RS07430	COG0628	permease
IB64_RS07435	COG1435	thymidine kinase activity
IB64_RS07445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IB64_RS07460	COG2095	MarC family integral membrane protein
IB64_RS07470	COG1629	transport
IB64_RS07470	COG4206	TonB-dependent receptor
IB64_RS07480	COG4974	Belongs to the 'phage' integrase family
IB64_RS07485	COG1629	transport
IB64_RS07485	COG4206	TonB-dependent receptor
IB64_RS07495	COG4771	TonB-dependent receptor
IB64_RS07500	COG0702	epimerase
IB64_RS07505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IB64_RS07525	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IB64_RS07525	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IB64_RS07540	COG0531	amino acid
IB64_RS07550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IB64_RS07555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IB64_RS07560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IB64_RS07600	COG1162	GTPase activity
IB64_RS07605	COG0233	cytoplasmic translational termination
IB64_RS07625	COG0443	Heat shock 70 kDa protein
IB64_RS07635	COG0528	UMP kinase activity
IB64_RS07640	COG0534	Mate efflux family protein
IB64_RS07665	COG0792	nuclease activity
IB64_RS07685	COG1183	phosphatidylcholine synthase activity
IB64_RS07690	COG0688	phosphatidylethanolamine metabolic process
IB64_RS07700	COG3118	belongs to the thioredoxin family
IB64_RS07735	COG0714	Associated with various cellular activities
IB64_RS07750	COG0802	atpase or kinase
IB64_RS07755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IB64_RS07765	COG2234	aminopeptidase activity
IB64_RS07790	COG1629	transport
IB64_RS07810	COG3250	beta-galactosidase activity
IB64_RS07825	COG0784	Response regulator, receiver
IB64_RS07825	COG2205	protein histidine kinase activity
IB64_RS07840	COG1566	PFAM secretion protein HlyD family protein
IB64_RS07860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IB64_RS07875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IB64_RS07880	COG0742	ribosomal rna small subunit methyltransferase
IB64_RS07905	COG4771	TonB-dependent receptor
IB64_RS07915	COG3537	Alpha-1,2-mannosidase
IB64_RS07930	COG3537	Alpha-1,2-mannosidase
IB64_RS07935	COG2814	Major facilitator Superfamily
IB64_RS07960	COG0739	heme binding
IB64_RS07970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IB64_RS07975	COG1388	LysM domain
IB64_RS07975	COG3942	CHAP domain
IB64_RS07985	COG1475	DNA binding
IB64_RS07990	COG1192	Involved in chromosome partitioning
IB64_RS08000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IB64_RS08005	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IB64_RS08020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IB64_RS08025	COG0799	negative regulation of ribosome biogenesis
IB64_RS08040	COG2239	Acts as a magnesium transporter
IB64_RS08045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IB64_RS08055	COG2195	Cleaves the N-terminal amino acid of tripeptides
IB64_RS08120	COG0668	transmembrane transport
IB64_RS08125	COG0662	Cupin 2, conserved barrel domain protein
IB64_RS08125	COG2207	Transcriptional regulator
IB64_RS08170	COG1215	transferase activity, transferring glycosyl groups
IB64_RS08225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IB64_RS08235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IB64_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
IB64_RS08255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IB64_RS08260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IB64_RS08270	COG1373	ATPase (AAA superfamily
IB64_RS08275	COG0667	Aldo Keto reductase
IB64_RS08280	COG1472	Belongs to the glycosyl hydrolase 3 family
IB64_RS08285	COG4771	TonB-dependent receptor
IB64_RS08290	COG0702	epimerase
IB64_RS08330	COG5012	cobalamin binding
IB64_RS08340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IB64_RS08345	COG4124	Belongs to the glycosyl hydrolase 26 family
IB64_RS08350	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IB64_RS08355	COG2211	Major facilitator Superfamily
IB64_RS08360	COG2942	2-epimerase
IB64_RS08400	COG4412	M6 family metalloprotease domain protein
IB64_RS08400	COG1404	Belongs to the peptidase S8 family
IB64_RS08410	COG5002	protein histidine kinase activity
IB64_RS08410	COG0784	Response regulator, receiver
IB64_RS08410	COG2205	protein histidine kinase activity
IB64_RS08420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IB64_RS08425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IB64_RS08430	COG0713	ATP synthesis coupled electron transport
IB64_RS08435	COG0839	Belongs to the complex I subunit 6 family
IB64_RS08445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IB64_RS08450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IB64_RS08450	COG0649	NAD binding
IB64_RS08455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IB64_RS08460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IB64_RS08470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IB64_RS08475	COG0569	domain protein
IB64_RS08480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IB64_RS08485	COG1073	alpha beta
IB64_RS08500	COG0546	phosphoglycolate phosphatase activity
IB64_RS08505	COG3119	arylsulfatase activity
IB64_RS08520	COG3119	arylsulfatase activity
IB64_RS08530	COG1629	transport
IB64_RS08535	COG2205	protein histidine kinase activity
IB64_RS08535	COG0745	RESPONSE REGULATOR receiver
IB64_RS08535	COG3292	Two component regulator propeller
IB64_RS08540	COG2271	Major facilitator Superfamily
IB64_RS08560	COG0805	protein transport
IB64_RS08565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IB64_RS08570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IB64_RS08590	COG4585	Histidine kinase
IB64_RS08605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IB64_RS08615	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IB64_RS08620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IB64_RS08620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IB64_RS08625	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IB64_RS08630	COG1078	dGTPase activity
IB64_RS08635	COG0284	orotidine-5'-phosphate decarboxylase activity
IB64_RS08640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IB64_RS08645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IB64_RS08655	COG1704	LemA family
IB64_RS08670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IB64_RS08675	COG2226	methyltransferase
IB64_RS08680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IB64_RS08685	COG1702	phosphate starvation-inducible protein PhoH
IB64_RS08695	COG2268	Band 7 protein
IB64_RS08705	COG5434	Belongs to the glycosyl hydrolase 28 family
IB64_RS08715	COG0101	tRNA pseudouridine synthase activity
IB64_RS08735	COG3250	beta-galactosidase activity
IB64_RS08740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IB64_RS08765	COG0457	Tetratricopeptide repeat
IB64_RS08770	COG2814	Major facilitator Superfamily
IB64_RS08850	COG0358	DNA primase activity
IB64_RS08975	COG2205	protein histidine kinase activity
IB64_RS08975	COG0784	Response regulator, receiver
IB64_RS08975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IB64_RS08975	COG2198	Histidine kinase
IB64_RS09010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IB64_RS09010	COG0551	DNA topoisomerase type I activity
IB64_RS09045	COG4974	Belongs to the 'phage' integrase family
IB64_RS09070	COG0702	epimerase
IB64_RS09075	COG4206	TonB-dependent receptor
IB64_RS09075	COG1629	transport
IB64_RS09085	COG4771	TonB-dependent receptor
IB64_RS09095	COG4206	TonB-dependent receptor
IB64_RS09095	COG1629	transport
IB64_RS09110	COG4206	TonB-dependent receptor
IB64_RS09110	COG1629	transport
IB64_RS09120	COG0673	inositol 2-dehydrogenase activity
IB64_RS09160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IB64_RS09165	COG0793	Belongs to the peptidase S41A family
IB64_RS09170	COG2131	deaminase
IB64_RS09180	COG0339	signal peptide processing
IB64_RS09190	COG1970	mechanosensitive ion channel activity
IB64_RS09195	COG0519	Catalyzes the synthesis of GMP from XMP
IB64_RS09195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IB64_RS09205	COG4206	TonB-dependent receptor
IB64_RS09205	COG1629	transport
IB64_RS09215	COG4771	TonB-dependent receptor
IB64_RS09220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IB64_RS09230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IB64_RS09240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IB64_RS09245	COG1506	peptidase
IB64_RS09245	COG0823	Involved in the tonB-independent uptake of proteins
IB64_RS09265	COG1242	4 iron, 4 sulfur cluster binding
IB64_RS09275	COG0363	glucosamine-6-phosphate deaminase activity
IB64_RS09285	COG0009	L-threonylcarbamoyladenylate synthase
IB64_RS09295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IB64_RS09300	COG0561	phosphatase activity
IB64_RS09305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IB64_RS09310	COG0626	cystathionine gamma-synthase activity
IB64_RS09350	COG0438	transferase activity, transferring glycosyl groups
IB64_RS09365	COG0297	glycogen (starch) synthase activity
IB64_RS09370	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IB64_RS09375	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IB64_RS09380	COG0543	2 iron, 2 sulfur cluster binding
IB64_RS09390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IB64_RS09400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IB64_RS09405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IB64_RS09420	COG0546	phosphoglycolate phosphatase activity
IB64_RS09425	COG0791	NLP P60 protein
IB64_RS09430	COG1131	(ABC) transporter
IB64_RS09440	COG0612	Peptidase, M16
IB64_RS09445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IB64_RS09450	COG1597	lipid kinase activity
IB64_RS09465	COG1136	(ABC) transporter
IB64_RS09485	COG2211	Major facilitator Superfamily
IB64_RS09495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IB64_RS09510	COG1674	ftsk spoiiie
IB64_RS09520	COG0492	ferredoxin-NADP+ reductase activity
IB64_RS09525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS09565	COG1595	DNA-templated transcription, initiation
IB64_RS09580	COG3956	TIGRFAM MazG family protein
IB64_RS09590	COG0525	valine-tRNA ligase activity
IB64_RS09595	COG0784	Response regulator, receiver
IB64_RS09595	COG2198	Histidine kinase
IB64_RS09595	COG2205	protein histidine kinase activity
IB64_RS09615	COG4771	TonB-dependent receptor
IB64_RS09630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IB64_RS09645	COG4771	TonB-dependent receptor
IB64_RS09650	COG0702	epimerase
IB64_RS09655	COG3119	arylsulfatase activity
IB64_RS09660	COG3119	arylsulfatase activity
IB64_RS09680	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
IB64_RS09690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IB64_RS09710	COG1253	flavin adenine dinucleotide binding
IB64_RS09720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IB64_RS09730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IB64_RS09770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IB64_RS09800	COG1086	Polysaccharide biosynthesis protein
IB64_RS09805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IB64_RS09810	COG1083	cytidylyl-transferase
IB64_RS09820	COG1181	Belongs to the D-alanine--D-alanine ligase family
IB64_RS09825	COG2089	acid synthase
IB64_RS09850	COG0438	transferase activity, transferring glycosyl groups
IB64_RS09875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IB64_RS09890	COG4771	TonB-dependent receptor
IB64_RS09900	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IB64_RS09905	COG0563	adenylate kinase activity
IB64_RS09910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IB64_RS09915	COG1496	oxidoreductase activity
IB64_RS09935	COG2706	6-phosphogluconolactonase activity
IB64_RS09955	COG2207	Transcriptional regulator
IB64_RS09975	COG1288	antiporter activity
IB64_RS10010	COG0454	-acetyltransferase
IB64_RS10015	COG0564	pseudouridine synthase activity
IB64_RS10030	COG1501	Belongs to the glycosyl hydrolase 31 family
IB64_RS10060	COG3011	Protein conserved in bacteria
IB64_RS10075	COG0148	phosphopyruvate hydratase activity
IB64_RS10085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IB64_RS10090	COG1082	Xylose isomerase domain protein TIM barrel
IB64_RS10115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IB64_RS10120	COG0193	aminoacyl-tRNA hydrolase activity
IB64_RS10125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IB64_RS10135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IB64_RS10140	COG1862	Preprotein translocase
IB64_RS10150	COG0237	dephospho-CoA kinase activity
IB64_RS10165	COG0542	response to heat
IB64_RS10175	COG0583	DNA-binding transcription factor activity
IB64_RS10180	COG2855	membrane
IB64_RS10195	COG1595	DNA-templated transcription, initiation
IB64_RS10210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IB64_RS10230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IB64_RS10250	COG0443	Heat shock 70 kDa protein
IB64_RS10265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IB64_RS10315	COG1917	Cupin 2, conserved barrel domain protein
IB64_RS10315	COG4977	sequence-specific DNA binding
IB64_RS10385	COG0110	maltose O-acetyltransferase activity
IB64_RS10390	COG1028	Short-chain dehydrogenase reductase Sdr
IB64_RS10395	COG1917	Cupin 2, conserved barrel domain protein
IB64_RS10395	COG2207	Transcriptional regulator
IB64_RS10425	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IB64_RS10430	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
IB64_RS10435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IB64_RS10455	COG1501	Belongs to the glycosyl hydrolase 31 family
IB64_RS10475	COG1629	transport
IB64_RS10475	COG4206	TonB-dependent receptor
IB64_RS10485	COG1408	metallophosphoesterase
IB64_RS10495	COG3634	alkyl hydroperoxide reductase activity
IB64_RS10530	COG1760	l-serine dehydratase
IB64_RS10535	COG0598	Magnesium transport protein CorA
IB64_RS10540	COG1193	negative regulation of DNA recombination
IB64_RS10550	COG0784	Response regulator, receiver
IB64_RS10550	COG5002	protein histidine kinase activity
IB64_RS10555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IB64_RS10560	COG2195	Cleaves the N-terminal amino acid of tripeptides
IB64_RS10565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IB64_RS10570	COG3189	MarR family transcriptional regulator
IB64_RS10575	COG2885	chlorophyll binding
IB64_RS10585	COG2217	Heavy metal translocating P-type atpase
IB64_RS10590	COG2855	membrane
IB64_RS10600	COG4206	TonB-dependent receptor
IB64_RS10600	COG1629	transport
IB64_RS10610	COG2207	Transcriptional regulator
IB64_RS10610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IB64_RS10635	COG4651	solute:proton antiporter activity
IB64_RS10635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IB64_RS10640	COG1280	lysine exporter protein (LysE YggA)
IB64_RS10655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IB64_RS10660	COG0561	phosphatase activity
IB64_RS10665	COG1169	isochorismate synthase
IB64_RS10670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IB64_RS10680	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IB64_RS10685	COG4948	Mandelate Racemase Muconate Lactonizing
IB64_RS10700	COG1082	Xylose isomerase domain protein TIM barrel
IB64_RS10715	COG4771	TonB-dependent receptor
IB64_RS10745	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IB64_RS10750	COG0783	Belongs to the Dps family
IB64_RS10775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IB64_RS10845	COG0358	DNA primase activity
IB64_RS10885	COG0156	8-amino-7-oxononanoate synthase activity
IB64_RS10915	COG0542	response to heat
IB64_RS11045	COG2755	lipolytic protein G-D-S-L family
IB64_RS11045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IB64_RS11070	COG1253	flavin adenine dinucleotide binding
IB64_RS11075	COG0501	Belongs to the peptidase M48B family
IB64_RS11105	COG2873	o-acetylhomoserine
IB64_RS11125	COG1757	Na H antiporter
IB64_RS11140	COG2814	Major facilitator Superfamily
IB64_RS11145	COG4953	penicillin-binding protein 1C
IB64_RS11150	COG2373	Large extracellular alpha-helical protein
IB64_RS11160	COG1918	ferrous iron import across plasma membrane
IB64_RS11160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IB64_RS11225	COG1086	Polysaccharide biosynthesis protein
IB64_RS11230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IB64_RS11245	COG1028	Short-chain dehydrogenase reductase Sdr
IB64_RS11255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IB64_RS11285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IB64_RS11290	COG0463	Glycosyl transferase, family 2
IB64_RS11290	COG1216	Glycosyl transferase, family 2
IB64_RS11300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IB64_RS11320	COG0490	domain, Protein
IB64_RS11320	COG0471	metal ion transport
IB64_RS11335	COG0346	lactoylglutathione lyase activity
IB64_RS11350	COG0259	pyridoxamine-phosphate oxidase activity
IB64_RS11355	COG1741	Belongs to the pirin family
IB64_RS11370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IB64_RS11400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IB64_RS11410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IB64_RS11425	COG1595	DNA-templated transcription, initiation
IB64_RS11450	COG0686	Belongs to the AlaDH PNT family
IB64_RS11470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IB64_RS11515	COG0488	(ABC) transporter
IB64_RS11520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IB64_RS11525	COG3059	membrane
IB64_RS11530	COG0662	Cupin 2, conserved barrel domain protein
IB64_RS11530	COG2207	Transcriptional regulator
IB64_RS11535	COG0295	cytidine deaminase activity
IB64_RS11540	COG1388	LysM domain
IB64_RS11540	COG1705	Flagellar rod assembly protein muramidase FlgJ
IB64_RS11555	COG0577	efflux transmembrane transporter activity
IB64_RS11565	COG0577	efflux transmembrane transporter activity
IB64_RS11575	COG0577	efflux transmembrane transporter activity
IB64_RS11585	COG1136	(ABC) transporter
IB64_RS11585	COG0577	efflux transmembrane transporter activity
IB64_RS11595	COG0662	Cupin 2, conserved barrel domain protein
IB64_RS11595	COG2207	Transcriptional regulator
IB64_RS11610	COG1136	(ABC) transporter
IB64_RS11615	COG1136	(ABC) transporter
IB64_RS11635	COG0784	Response regulator, receiver
IB64_RS11635	COG2205	protein histidine kinase activity
IB64_RS11645	COG2204	response regulator
IB64_RS11650	COG4191	Histidine kinase
IB64_RS11710	COG4974	Belongs to the 'phage' integrase family
IB64_RS11740	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IB64_RS11765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IB64_RS11785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IB64_RS11790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IB64_RS11800	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IB64_RS11805	COG1216	Glycosyl transferase, family 2
IB64_RS11805	COG1442	glycosyl transferase family 8
IB64_RS11815	COG1086	Polysaccharide biosynthesis protein
IB64_RS11825	COG1091	dTDP-4-dehydrorhamnose reductase activity
IB64_RS11835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS11840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IB64_RS11845	COG1530	ribonuclease E activity
IB64_RS11860	COG3119	arylsulfatase activity
IB64_RS11865	COG0629	single-stranded DNA binding
IB64_RS11935	COG4206	TonB-dependent receptor
IB64_RS11960	COG0745	RESPONSE REGULATOR receiver
IB64_RS11985	COG0488	(ABC) transporter
IB64_RS12000	COG5492	domain, Protein
IB64_RS12010	COG0436	Aminotransferase
IB64_RS12015	COG4591	ABC-type transport system involved in lipoprotein release permease component
IB64_RS12020	COG1215	transferase activity, transferring glycosyl groups
IB64_RS12025	COG0628	permease
IB64_RS12030	COG3852	Histidine kinase
IB64_RS12045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IB64_RS12055	COG0577	efflux transmembrane transporter activity
IB64_RS12055	COG1136	(ABC) transporter
IB64_RS12060	COG1136	(ABC) transporter
IB64_RS12060	COG0577	efflux transmembrane transporter activity
IB64_RS12065	COG1252	NADH dehydrogenase
IB64_RS12095	COG4771	TonB-dependent receptor
IB64_RS12105	COG1620	l-lactate permease
IB64_RS12125	COG3047	cAMP biosynthetic process
IB64_RS12125	COG2885	chlorophyll binding
IB64_RS12135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IB64_RS12140	COG0439	Biotin carboxylase
IB64_RS12145	COG0511	ligase activity, forming carbon-carbon bonds
IB64_RS12155	COG2226	methyltransferase
IB64_RS12160	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IB64_RS12195	COG0784	Response regulator, receiver
IB64_RS12195	COG2205	protein histidine kinase activity
IB64_RS12195	COG2198	Histidine kinase
IB64_RS12200	COG0508	dehydrogenase complex catalyzes the overall conversion of
IB64_RS12205	COG0022	dehydrogenase e1 component
IB64_RS12210	COG0716	FMN binding
IB64_RS12215	COG2264	protein methyltransferase activity
IB64_RS12230	COG0590	tRNA wobble adenosine to inosine editing
IB64_RS12255	COG0673	inositol 2-dehydrogenase activity
IB64_RS12260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IB64_RS12310	COG0698	ribose 5-phosphate isomerase
IB64_RS12315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IB64_RS12320	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IB64_RS12335	COG1482	cell wall glycoprotein biosynthetic process
IB64_RS12355	COG0513	Belongs to the DEAD box helicase family
IB64_RS12360	COG4221	oxidoreductase activity
IB64_RS12370	COG3250	beta-galactosidase activity
IB64_RS12380	COG3273	potassium ion transport
IB64_RS12380	COG0471	metal ion transport
IB64_RS12385	COG0529	Catalyzes the synthesis of activated sulfate
IB64_RS12390	COG0175	sulfate reduction
IB64_RS12410	COG2885	chlorophyll binding
IB64_RS12475	COG2204	response regulator
IB64_RS12480	COG2205	protein histidine kinase activity
IB64_RS12480	COG0784	Response regulator, receiver
IB64_RS12500	COG1538	Outer membrane efflux protein
IB64_RS12510	COG1566	PFAM secretion protein HlyD family protein
IB64_RS12515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IB64_RS12565	COG4974	Belongs to the 'phage' integrase family
IB64_RS12705	COG0358	DNA primase activity
IB64_RS12820	COG0519	Catalyzes the synthesis of GMP from XMP
IB64_RS12845	COG2198	Histidine kinase
IB64_RS12845	COG2205	protein histidine kinase activity
IB64_RS12845	COG0784	Response regulator, receiver
IB64_RS12845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IB64_RS12915	COG2226	methyltransferase
IB64_RS12925	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IB64_RS12945	COG0813	purine-nucleoside phosphorylase activity
IB64_RS12985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IB64_RS12985	COG0551	DNA topoisomerase type I activity
IB64_RS13025	COG4974	Belongs to the 'phage' integrase family
IB64_RS13055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IB64_RS13060	COG0242	peptide deformylase activity
IB64_RS13075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IB64_RS13080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IB64_RS13085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IB64_RS13090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IB64_RS13100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IB64_RS13105	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IB64_RS13110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IB64_RS13110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IB64_RS13110	COG1013	pyruvate-flavodoxin oxidoreductase activity
IB64_RS13110	COG0674	pyruvate-flavodoxin oxidoreductase activity
IB64_RS13120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IB64_RS13160	COG1940	carbohydrate kinase activity
IB64_RS13165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IB64_RS13175	COG2271	Major facilitator Superfamily
IB64_RS13180	COG2731	YhcH YjgK YiaL family protein
IB64_RS13185	COG1629	transport
IB64_RS13190	COG0702	epimerase
IB64_RS13200	COG1629	transport
IB64_RS13205	COG0702	epimerase
IB64_RS13225	COG4771	TonB-dependent receptor
IB64_RS13230	COG0702	epimerase
IB64_RS13235	COG0702	epimerase
IB64_RS13240	COG1629	transport
IB64_RS13240	COG4206	TonB-dependent receptor
IB64_RS13245	COG4206	TonB-dependent receptor
IB64_RS13245	COG1629	transport
IB64_RS13260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS13280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS13290	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS13295	COG3537	Alpha-1,2-mannosidase
IB64_RS13300	COG3250	beta-galactosidase activity
IB64_RS13305	COG4771	TonB-dependent receptor
IB64_RS13310	COG0702	epimerase
IB64_RS13315	COG0484	heat shock protein binding
IB64_RS13320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IB64_RS13325	COG0488	(ABC) transporter
IB64_RS13330	COG1595	DNA-templated transcription, initiation
IB64_RS13435	COG2885	chlorophyll binding
IB64_RS13540	COG2183	response to ionizing radiation
IB64_RS13550	COG0737	Belongs to the 5'-nucleotidase family
IB64_RS13555	COG1956	GAF domain-containing protein
IB64_RS13565	COG4771	TonB-dependent receptor
IB64_RS13590	COG0534	Mate efflux family protein
IB64_RS13635	COG0534	Mate efflux family protein
IB64_RS13645	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
IB64_RS13655	COG0318	PFAM AMP-dependent synthetase and ligase
IB64_RS13660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS13665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IB64_RS13730	COG1086	Polysaccharide biosynthesis protein
IB64_RS13740	COG1091	dTDP-4-dehydrorhamnose reductase activity
IB64_RS13750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS13775	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IB64_RS13780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IB64_RS13785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IB64_RS13790	COG0363	glucosamine-6-phosphate deaminase activity
IB64_RS13830	COG1742	UPF0060 membrane protein
IB64_RS13915	COG3279	Response regulator of the LytR AlgR family
IB64_RS13925	COG1136	(ABC) transporter
IB64_RS13925	COG0577	efflux transmembrane transporter activity
IB64_RS13930	COG1136	(ABC) transporter
IB64_RS13935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IB64_RS13970	COG3831	ATPase activity
IB64_RS13970	COG4884	unkown
IB64_RS13985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IB64_RS13995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IB64_RS14000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IB64_RS14005	COG3250	beta-galactosidase activity
IB64_RS14030	COG0501	Belongs to the peptidase M48B family
IB64_RS14035	COG1704	LemA family
IB64_RS14040	COG1595	DNA-templated transcription, initiation
IB64_RS14050	COG4206	TonB-dependent receptor
IB64_RS14050	COG1629	transport
IB64_RS14060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IB64_RS14065	COG2885	chlorophyll binding
IB64_RS14065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IB64_RS14075	COG0697	spore germination
IB64_RS14105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IB64_RS14110	COG0656	L-ascorbic acid biosynthetic process
IB64_RS14120	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IB64_RS14125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IB64_RS14130	COG2814	Major facilitator Superfamily
IB64_RS14135	COG4771	TonB-dependent receptor
IB64_RS14165	COG4771	TonB-dependent receptor
IB64_RS14210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IB64_RS14215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IB64_RS14295	COG0488	(ABC) transporter
IB64_RS14315	COG4999	Histidine kinase
IB64_RS14315	COG2205	protein histidine kinase activity
IB64_RS14315	COG3850	Histidine kinase
IB64_RS14315	COG3437	response regulator, receiver
IB64_RS14330	COG0438	transferase activity, transferring glycosyl groups
IB64_RS14340	COG0438	transferase activity, transferring glycosyl groups
IB64_RS14350	COG2244	polysaccharide biosynthetic process
IB64_RS14355	COG1442	glycosyl transferase family 8
IB64_RS14355	COG1216	Glycosyl transferase, family 2
IB64_RS14370	COG1215	transferase activity, transferring glycosyl groups
IB64_RS14400	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IB64_RS14405	COG1805	sodium ion transport
IB64_RS14410	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IB64_RS14435	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IB64_RS14440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IB64_RS14450	COG0545	Peptidyl-prolyl cis-trans isomerase
IB64_RS14455	COG1739	Uncharacterized protein family UPF0029
IB64_RS14465	COG0778	Nitroreductase
IB64_RS14470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IB64_RS14470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IB64_RS14475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IB64_RS14505	COG2217	Heavy metal translocating P-type atpase
IB64_RS14515	COG0321	lipoyl(octanoyl) transferase activity
IB64_RS14535	COG3852	Histidine kinase
IB64_RS14540	COG2204	response regulator
IB64_RS14555	COG1136	(ABC) transporter
IB64_RS14570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IB64_RS14580	COG1755	Isoprenylcysteine carboxyl methyltransferase
IB64_RS14590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IB64_RS14605	COG1678	Uncharacterized ACR, COG1678
IB64_RS14650	COG4771	TonB-dependent receptor
IB64_RS14660	COG3119	arylsulfatase activity
IB64_RS14665	COG3250	beta-galactosidase activity
IB64_RS14680	COG0681	Belongs to the peptidase S26 family
IB64_RS14715	COG3969	phosphoadenosine phosphosulfate
IB64_RS14720	COG1475	DNA binding
IB64_RS14765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS14770	COG0745	RESPONSE REGULATOR receiver
IB64_RS14785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS14795	COG1629	transport
IB64_RS14795	COG4206	TonB-dependent receptor
IB64_RS14805	COG4974	Belongs to the 'phage' integrase family
IB64_RS14900	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IB64_RS14920	COG1022	Amp-dependent synthetase and ligase
IB64_RS14925	COG3263	regulation of cellular component size
IB64_RS14935	COG1151	hydroxylamine reductase activity
IB64_RS14950	COG2204	response regulator
IB64_RS14970	COG1136	(ABC) transporter
IB64_RS14970	COG0577	efflux transmembrane transporter activity
IB64_RS14980	COG1136	(ABC) transporter
IB64_RS14980	COG0577	efflux transmembrane transporter activity
IB64_RS14990	COG0534	Mate efflux family protein
IB64_RS15000	COG0167	dihydroorotate dehydrogenase activity
IB64_RS15005	COG0657	acetylesterase activity
IB64_RS15005	COG2755	lipolytic protein G-D-S-L family
IB64_RS15010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IB64_RS15025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IB64_RS15045	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IB64_RS15055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IB64_RS15065	COG0356	it plays a direct role in the translocation of protons across the membrane
IB64_RS15070	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IB64_RS15075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IB64_RS15080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IB64_RS15085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IB64_RS15090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IB64_RS15095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IB64_RS15100	COG3118	belongs to the thioredoxin family
IB64_RS15120	COG0745	RESPONSE REGULATOR receiver
IB64_RS15125	COG5002	protein histidine kinase activity
IB64_RS15160	COG1120	ATPase activity
IB64_RS15165	COG1091	dTDP-4-dehydrorhamnose reductase activity
IB64_RS15205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IB64_RS15210	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IB64_RS15225	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IB64_RS15230	COG1064	alcohol dehydrogenase
IB64_RS15245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IB64_RS15255	COG2205	protein histidine kinase activity
IB64_RS15255	COG2202	Pas domain
IB64_RS15260	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IB64_RS15270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IB64_RS15285	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IB64_RS15290	COG0540	Belongs to the ATCase OTCase family
IB64_RS15305	COG2431	L-lysine efflux transmembrane transporter activity
IB64_RS15335	COG2837	iron assimilation
IB64_RS15345	COG1629	transport
IB64_RS15345	COG4206	TonB-dependent receptor
IB64_RS15365	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IB64_RS15375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IB64_RS15390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IB64_RS15395	COG2205	protein histidine kinase activity
IB64_RS15415	COG2135	peptidase activity
IB64_RS15425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IB64_RS15430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IB64_RS15455	COG0673	inositol 2-dehydrogenase activity
IB64_RS15470	COG2223	nitrite transmembrane transporter activity
IB64_RS15490	COG0671	phosphoesterase, PA-phosphatase related
IB64_RS15505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IB64_RS15510	COG0045	succinate-CoA ligase (ADP-forming) activity
IB64_RS15515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IB64_RS15520	COG0351	phosphomethylpyrimidine kinase
IB64_RS15540	COG0477	Major facilitator Superfamily
IB64_RS15540	COG2814	Major facilitator Superfamily
IB64_RS15550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IB64_RS15550	COG3153	acetyltransferase
IB64_RS15555	COG0450	alkyl hydroperoxide reductase
IB64_RS15560	COG0724	RNA recognition motif
IB64_RS15565	COG1858	cytochrome C peroxidase
IB64_RS15570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IB64_RS15595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IB64_RS15605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IB64_RS15620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IB64_RS15700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IB64_RS15710	COG1904	glucuronate isomerase
IB64_RS15740	COG0513	Belongs to the DEAD box helicase family
IB64_RS15745	COG0560	Phosphoserine phosphatase
IB64_RS15745	COG3830	Belongs to the UPF0237 family
IB64_RS15770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IB64_RS15775	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IB64_RS15835	COG2204	response regulator
IB64_RS15885	COG0577	efflux transmembrane transporter activity
IB64_RS15885	COG1136	(ABC) transporter
IB64_RS15895	COG0156	8-amino-7-oxononanoate synthase activity
IB64_RS15900	COG1597	lipid kinase activity
IB64_RS15905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IB64_RS15930	COG1136	(ABC) transporter
IB64_RS15930	COG0577	efflux transmembrane transporter activity
IB64_RS15955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IB64_RS15985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IB64_RS16005	COG0543	2 iron, 2 sulfur cluster binding
IB64_RS16010	COG0167	dihydroorotate dehydrogenase activity
IB64_RS16015	COG0336	Belongs to the RNA methyltransferase TrmD family
IB64_RS16020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IB64_RS16025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IB64_RS16050	COG0326	Molecular chaperone. Has ATPase activity
IB64_RS16055	COG0542	response to heat
IB64_RS16100	COG2304	oxidoreductase activity
IB64_RS16115	COG0714	Associated with various cellular activities
IB64_RS16120	COG1652	LysM domain
IB64_RS16130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IB64_RS16135	COG0552	protein localization to endoplasmic reticulum
IB64_RS16145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IB64_RS16150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IB64_RS16155	COG1058	Belongs to the CinA family
IB64_RS16155	COG1546	Belongs to the CinA family
IB64_RS16160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IB64_RS16175	COG0442	prolyl-tRNA aminoacylation
IB64_RS16190	COG4946	Tricorn protease homolog
IB64_RS16190	COG0793	Belongs to the peptidase S41A family
IB64_RS16210	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IB64_RS16225	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IB64_RS16235	COG1492	cobalamin metabolic process
IB64_RS16270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IB64_RS16290	COG2096	Adenosyltransferase
IB64_RS16295	COG1797	cobyrinic acid a,c-diamide synthase activity
IB64_RS16310	COG2966	Psort location CytoplasmicMembrane, score
IB64_RS16320	COG4771	TonB-dependent receptor
IB64_RS16330	COG4774	siderophore transport
IB64_RS16355	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IB64_RS16470	COG0305	Participates in initiation and elongation during chromosome replication
IB64_RS16480	COG3023	N-Acetylmuramoyl-L-alanine amidase
IB64_RS16535	COG0352	thiamine-phosphate diphosphorylase activity
IB64_RS16540	COG2022	thiamine diphosphate biosynthetic process
IB64_RS16545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IB64_RS16560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IB64_RS16565	COG0352	thiamine-phosphate diphosphorylase activity
IB64_RS16600	COG0358	DNA primase activity
IB64_RS16670	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IB64_RS16720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IB64_RS16825	COG0500	methyltransferase
IB64_RS16835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IB64_RS16875	COG4974	Belongs to the 'phage' integrase family
IB64_RS16915	COG1192	Involved in chromosome partitioning
IB64_RS16925	COG1401	restriction endodeoxyribonuclease activity
IB64_RS16950	COG0574	Belongs to the PEP-utilizing enzyme family
IB64_RS16950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IB64_RS16955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IB64_RS16960	COG0564	pseudouridine synthase activity
IB64_RS16975	COG0024	Methionine aminopeptidase
IB64_RS17000	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IB64_RS17010	COG0481	GTPase activity
IB64_RS17030	COG0708	Exodeoxyribonuclease III
IB64_RS17035	COG1914	H( )-stimulated, divalent metal cation uptake system
IB64_RS17050	COG0217	transcriptional regulatory protein
IB64_RS17055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IB64_RS17055	COG0072	phenylalanine-tRNA ligase activity
IB64_RS17060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IB64_RS17065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS17085	COG1216	Glycosyl transferase, family 2
IB64_RS17090	COG1216	Glycosyl transferase, family 2
IB64_RS17110	COG0028	Belongs to the TPP enzyme family
IB64_RS17115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS17125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IB64_RS17165	COG0305	Participates in initiation and elongation during chromosome replication
IB64_RS17170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IB64_RS17185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IB64_RS17190	COG4657	Part of a membrane complex involved in electron transport
IB64_RS17195	COG4660	Part of a membrane complex involved in electron transport
IB64_RS17200	COG4659	FMN binding
IB64_RS17205	COG4658	electron transport chain
IB64_RS17210	COG4656	Part of a membrane complex involved in electron transport
IB64_RS17235	COG0504	CTP synthase activity
IB64_RS17245	COG0534	Mate efflux family protein
IB64_RS17250	COG1506	peptidase
IB64_RS17250	COG0823	Involved in the tonB-independent uptake of proteins
IB64_RS17265	COG0110	maltose O-acetyltransferase activity
IB64_RS17275	COG1695	Transcriptional regulator
IB64_RS17290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IB64_RS17300	COG1388	LysM domain
IB64_RS17300	COG3942	CHAP domain
IB64_RS17330	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IB64_RS17350	COG0556	nucleotide-excision repair
IB64_RS17360	COG2949	membrane
IB64_RS17385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IB64_RS17405	COG0842	Transport permease protein
IB64_RS17410	COG0842	Transport permease protein
IB64_RS17415	COG1131	(ABC) transporter
IB64_RS17450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IB64_RS17455	COG0505	Belongs to the CarA family
IB64_RS17470	COG0069	glutamate synthase activity
IB64_RS17470	COG0070	glutamate synthase
IB64_RS17470	COG0067	glutamate synthase
IB64_RS17480	COG0367	asparagine synthase
IB64_RS17495	COG3275	phosphorelay sensor kinase activity
IB64_RS17525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IB64_RS17535	COG1979	alcohol dehydrogenase
IB64_RS17550	COG0133	tryptophan synthase activity
IB64_RS17555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IB64_RS17570	COG0134	indole-3-glycerol-phosphate synthase activity
IB64_RS17575	COG0135	phosphoribosylanthranilate isomerase activity
IB64_RS17580	COG0159	tryptophan synthase activity
IB64_RS17585	COG0252	asparaginase activity
IB64_RS17595	COG0745	RESPONSE REGULATOR receiver
IB64_RS17595	COG3292	Two component regulator propeller
IB64_RS17595	COG2205	protein histidine kinase activity
IB64_RS17600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IB64_RS17610	COG0110	maltose O-acetyltransferase activity
IB64_RS17615	COG2197	response regulator
IB64_RS17625	COG0138	bifunctional purine biosynthesis protein purh
IB64_RS17630	COG0716	FMN binding
IB64_RS17655	COG1858	cytochrome C peroxidase
IB64_RS17665	COG4771	TonB-dependent receptor
IB64_RS17680	COG2814	Major facilitator Superfamily
IB64_RS17685	COG1566	PFAM secretion protein HlyD family protein
IB64_RS17695	COG1230	cation diffusion facilitator family transporter
IB64_RS17715	COG4771	TonB-dependent receptor
IB64_RS17745	COG3610	response to peptide
IB64_RS17760	COG1609	Transcriptional regulator
IB64_RS17770	COG1733	regulation of RNA biosynthetic process
IB64_RS17780	COG0784	Response regulator, receiver
IB64_RS17780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IB64_RS17780	COG2198	Histidine kinase
IB64_RS17780	COG2205	protein histidine kinase activity
IB64_RS17790	COG5002	protein histidine kinase activity
IB64_RS17795	COG0745	RESPONSE REGULATOR receiver
IB64_RS17815	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IB64_RS17820	COG1690	Belongs to the RtcB family
IB64_RS17840	COG0228	four-way junction DNA binding
IB64_RS17855	COG0724	RNA recognition motif
IB64_RS17865	COG1177	transmembrane transport
IB64_RS17870	COG1176	ABC-type spermidine putrescine transport system, permease component I
IB64_RS17880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IB64_RS17895	COG0058	SHG alpha-glucan phosphorylase activity
IB64_RS17905	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IB64_RS17925	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IB64_RS17985	COG0745	RESPONSE REGULATOR receiver
IB64_RS17990	COG5002	protein histidine kinase activity
IB64_RS18020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IB64_RS18030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IB64_RS18045	COG4948	Mandelate Racemase Muconate Lactonizing
IB64_RS18060	COG1295	ribonuclease BN
IB64_RS18065	COG0778	Nitroreductase
IB64_RS18075	COG0704	Plays a role in the regulation of phosphate uptake
IB64_RS18080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IB64_RS18085	COG0581	inorganic phosphate transmembrane transporter activity
IB64_RS18090	COG0573	inorganic phosphate transmembrane transporter activity
IB64_RS18100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IB64_RS18125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IB64_RS18160	COG3023	N-Acetylmuramoyl-L-alanine amidase
IB64_RS18210	COG1216	Glycosyl transferase, family 2
IB64_RS18220	COG1216	Glycosyl transferase, family 2
IB64_RS18245	COG1216	Glycosyl transferase, family 2
IB64_RS18255	COG1045	serine acetyltransferase
IB64_RS18275	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IB64_RS18320	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IB64_RS18320	COG0662	Cupin 2, conserved barrel domain protein
IB64_RS18325	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IB64_RS18345	COG1363	Peptidase, m42
IB64_RS18385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IB64_RS18390	COG0167	dihydroorotate dehydrogenase activity
IB64_RS18455	COG5002	protein histidine kinase activity
IB64_RS18470	COG2172	sigma factor antagonist activity
IB64_RS18495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IB64_RS18515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IB64_RS18520	COG0497	DNA recombination
IB64_RS18530	COG5002	protein histidine kinase activity
IB64_RS18530	COG2176	DNA-directed DNA polymerase activity
IB64_RS18535	COG0592	DNA-directed DNA polymerase activity
IB64_RS18550	COG0321	lipoyl(octanoyl) transferase activity
IB64_RS18550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IB64_RS18565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS18575	COG0156	8-amino-7-oxononanoate synthase activity
IB64_RS18685	COG0019	diaminopimelate decarboxylase activity
IB64_RS18690	COG0527	aspartate kinase activity
IB64_RS18695	COG2884	Cell division ATP-binding protein ftsE
IB64_RS18700	COG0140	phosphoribosyl-ATP diphosphatase activity
IB64_RS18700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IB64_RS18705	COG0107	imidazoleglycerol-phosphate synthase activity
IB64_RS18710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IB64_RS18735	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IB64_RS18785	COG2197	response regulator
IB64_RS18805	COG3586	endonuclease activity
IB64_RS18850	COG1917	Cupin 2, conserved barrel domain protein
IB64_RS18850	COG4977	sequence-specific DNA binding
IB64_RS18860	COG0693	protein deglycase activity
IB64_RS18875	COG0494	nUDIX hydrolase
IB64_RS18890	COG3326	Membrane
IB64_RS18990	COG0561	phosphatase activity
IB64_RS19065	COG0363	glucosamine-6-phosphate deaminase activity
IB64_RS19070	COG2365	Tyrosine phosphatase family
IB64_RS19105	COG1032	radical SAM domain protein
IB64_RS19110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IB64_RS19115	COG0463	Glycosyl transferase, family 2
IB64_RS19120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IB64_RS19125	COG1410	methionine synthase
IB64_RS19125	COG0646	methionine synthase
IB64_RS19165	COG1408	metallophosphoesterase
IB64_RS19170	COG1132	(ABC) transporter
IB64_RS19175	COG1132	(ABC) transporter
IB64_RS19185	COG0420	3'-5' exonuclease activity
IB64_RS19220	COG0681	Belongs to the peptidase S26 family
IB64_RS19325	COG0641	radical SAM
IB64_RS19330	COG3591	Belongs to the peptidase S1B family
IB64_RS19335	COG3591	Belongs to the peptidase S1B family
IB64_RS19370	COG1592	Rubrerythrin
IB64_RS19370	COG1773	rubredoxin
IB64_RS19380	COG3152	Membrane
IB64_RS19385	COG0339	signal peptide processing
IB64_RS19390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IB64_RS19390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IB64_RS19400	COG4206	TonB-dependent receptor
IB64_RS19400	COG1629	transport
IB64_RS19415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IB64_RS19415	COG0131	Imidazoleglycerol-phosphate dehydratase
IB64_RS19425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IB64_RS19430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IB64_RS19440	COG1741	Belongs to the pirin family
IB64_RS19445	COG4232	protein-disulfide reductase activity
IB64_RS19455	COG0572	uridine kinase
IB64_RS19460	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IB64_RS19465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IB64_RS19475	COG1410	methionine synthase
IB64_RS19475	COG0646	methionine synthase
IB64_RS19480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IB64_RS19515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IB64_RS19525	COG1295	ribonuclease BN
IB64_RS19535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IB64_RS19540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IB64_RS19545	COG0277	FAD linked oxidase domain protein
IB64_RS19545	COG0247	lactate metabolic process
IB64_RS19645	COG5002	protein histidine kinase activity
IB64_RS19650	COG2202	Pas domain
IB64_RS19650	COG2205	protein histidine kinase activity
IB64_RS19655	COG0534	Mate efflux family protein
IB64_RS19660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IB64_RS19665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IB64_RS19670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IB64_RS19735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IB64_RS19775	COG2195	Cleaves the N-terminal amino acid of tripeptides
IB64_RS19785	COG0668	transmembrane transport
IB64_RS19790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IB64_RS19800	COG3250	beta-galactosidase activity
IB64_RS19805	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS19810	COG3119	arylsulfatase activity
IB64_RS19815	COG3119	arylsulfatase activity
IB64_RS19820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS19825	COG0745	RESPONSE REGULATOR receiver
IB64_RS19825	COG2205	protein histidine kinase activity
IB64_RS19825	COG3292	Two component regulator propeller
IB64_RS19830	COG1830	Aldolase
IB64_RS19835	COG0588	phosphoglycerate mutase activity
IB64_RS19840	COG1119	ATPase activity
IB64_RS19845	COG3119	arylsulfatase activity
IB64_RS19850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS19860	COG1629	transport
IB64_RS19860	COG4206	TonB-dependent receptor
IB64_RS19875	COG1523	belongs to the glycosyl hydrolase 13 family
IB64_RS19880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IB64_RS19970	COG3179	chitinase
IB64_RS20010	COG0175	sulfate reduction
IB64_RS20105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IB64_RS20120	COG0126	phosphoglycerate kinase activity
IB64_RS20135	COG2311	Membrane
IB64_RS20185	COG0424	maF-like protein
IB64_RS20190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IB64_RS20205	COG0778	Nitroreductase
IB64_RS20210	COG0288	reversible hydration of carbon dioxide
IB64_RS20225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IB64_RS20235	COG5016	pyruvate
IB64_RS20235	COG0511	ligase activity, forming carbon-carbon bonds
IB64_RS20240	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IB64_RS20255	COG0366	Alpha amylase catalytic
IB64_RS20275	COG0191	fructose-bisphosphate aldolase activity
IB64_RS20285	COG0254	rRNA binding
IB64_RS20310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IB64_RS20315	COG1629	transport
IB64_RS20315	COG4206	TonB-dependent receptor
IB64_RS20320	COG1609	Transcriptional regulator
IB64_RS20365	COG1554	hydrolase, family 65, central catalytic
IB64_RS20370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IB64_RS20395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IB64_RS20395	COG0047	phosphoribosylformylglycinamidine synthase activity
IB64_RS20400	COG3292	Two component regulator propeller
IB64_RS20400	COG2205	protein histidine kinase activity
IB64_RS20400	COG0745	RESPONSE REGULATOR receiver
IB64_RS20415	COG1649	PFAM Uncharacterised BCR, COG1649
IB64_RS20435	COG1966	Carbon starvation protein
IB64_RS20445	COG1649	PFAM Uncharacterised BCR, COG1649
IB64_RS20450	COG2205	protein histidine kinase activity
IB64_RS20500	COG2113	Glycine betaine
IB64_RS20505	COG4176	ABC-type proline glycine betaine transport system permease component
IB64_RS20520	COG0745	RESPONSE REGULATOR receiver
IB64_RS20520	COG2205	protein histidine kinase activity
IB64_RS20520	COG3292	Two component regulator propeller
IB64_RS20525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IB64_RS20525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IB64_RS20535	COG1621	beta-fructofuranosidase activity
IB64_RS20590	COG0738	Major facilitator superfamily
IB64_RS20605	COG1752	Esterase of the alpha-beta hydrolase superfamily
IB64_RS20610	COG0475	glutathione-regulated potassium exporter activity
IB64_RS20635	COG3015	lipoprotein NlpE involved in copper resistance
IB64_RS20645	COG3279	Response regulator of the LytR AlgR family
IB64_RS20670	COG4771	TonB-dependent receptor
IB64_RS20675	COG0702	epimerase
IB64_RS20690	COG4948	Mandelate Racemase Muconate Lactonizing
IB64_RS20700	COG4206	TonB-dependent receptor
IB64_RS20700	COG1629	transport
IB64_RS20705	COG0702	epimerase
IB64_RS20725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IB64_RS20745	COG0484	heat shock protein binding
IB64_RS20755	COG2194	sulfuric ester hydrolase activity
IB64_RS20805	COG0028	Belongs to the TPP enzyme family
IB64_RS20830	COG0459	protein refolding
IB64_RS20835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IB64_RS20875	COG2326	polyphosphate kinase activity
IB64_RS20925	COG3537	Alpha-1,2-mannosidase
IB64_RS20930	COG1506	peptidase
IB64_RS20930	COG0823	Involved in the tonB-independent uptake of proteins
IB64_RS20965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IB64_RS21000	COG0514	ATP-dependent DNA helicase (RecQ)
IB64_RS21015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IB64_RS21025	COG0671	phosphoesterase, PA-phosphatase related
IB64_RS21030	COG0702	epimerase
IB64_RS21035	COG1629	transport
IB64_RS21035	COG4206	TonB-dependent receptor
IB64_RS21065	COG0463	Glycosyl transferase, family 2
IB64_RS21080	COG0066	3-isopropylmalate dehydratase activity
IB64_RS21085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IB64_RS21090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IB64_RS21135	COG0616	signal peptide processing
IB64_RS21140	COG1663	tetraacyldisaccharide 4'-kinase activity
IB64_RS21145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IB64_RS21150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IB64_RS21215	COG1196	nuclear chromosome segregation
IB64_RS21225	COG1431	PFAM Stem cell self-renewal protein Piwi
IB64_RS21240	COG4974	Belongs to the 'phage' integrase family
IB64_RS21245	COG4974	Belongs to the 'phage' integrase family
IB64_RS21295	COG0776	regulation of translation
IB64_RS21370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IB64_RS21390	COG2207	Transcriptional regulator
IB64_RS21390	COG1917	Cupin 2, conserved barrel domain protein
IB64_RS21400	COG1028	Short-chain dehydrogenase reductase Sdr
IB64_RS21420	COG0463	Glycosyl transferase, family 2
IB64_RS21435	COG1971	Probably functions as a manganese efflux pump
IB64_RS21440	COG1477	protein flavinylation
IB64_RS21450	COG0037	tRNA processing
IB64_RS21465	COG4864	UPF0365 protein
IB64_RS21475	COG2176	DNA-directed DNA polymerase activity
IB64_RS21480	COG2910	NAD(P)H-binding
IB64_RS21490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IB64_RS21500	COG4974	Belongs to the 'phage' integrase family
IB64_RS21610	COG4974	Belongs to the 'phage' integrase family
IB64_RS21635	COG1910	domain protein
IB64_RS21670	COG4974	Belongs to the 'phage' integrase family
IB64_RS21700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IB64_RS21750	COG1028	Short-chain dehydrogenase reductase Sdr
IB64_RS21765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IB64_RS21770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IB64_RS21775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IB64_RS21775	COG4651	solute:proton antiporter activity
IB64_RS21780	COG0439	Biotin carboxylase
IB64_RS21785	COG0511	ligase activity, forming carbon-carbon bonds
IB64_RS21790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IB64_RS21795	COG4977	sequence-specific DNA binding
IB64_RS21795	COG1917	Cupin 2, conserved barrel domain protein
IB64_RS21805	COG1335	isochorismatase
IB64_RS21815	COG2205	protein histidine kinase activity
IB64_RS21815	COG0784	Response regulator, receiver
IB64_RS21815	COG5002	protein histidine kinase activity
IB64_RS21820	COG2207	Transcriptional regulator
IB64_RS21825	COG0517	IMP dehydrogenase activity
IB64_RS21825	COG0516	GMP reductase activity
IB64_RS21860	COG2873	o-acetylhomoserine
IB64_RS21895	COG0110	maltose O-acetyltransferase activity
IB64_RS21905	COG2076	Multidrug Resistance protein
IB64_RS21945	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IB64_RS21955	COG1388	LysM domain
IB64_RS21955	COG0741	lytic transglycosylase activity
IB64_RS21960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IB64_RS21965	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IB64_RS21965	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IB64_RS21975	COG1285	pathogenesis
IB64_RS21995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IB64_RS21995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IB64_RS22010	COG1115	amino acid carrier protein
IB64_RS22020	COG1509	lysine 2,3-aminomutase activity
IB64_RS22030	COG2233	PERMEase
IB64_RS22045	COG1393	Belongs to the ArsC family
IB64_RS22055	COG1629	transport
IB64_RS22065	COG2304	oxidoreductase activity
IB64_RS22075	COG0351	phosphomethylpyrimidine kinase
IB64_RS22085	COG1139	Iron-sulfur cluster binding protein
IB64_RS22090	COG0247	lactate metabolic process
IB64_RS22095	COG0602	queuosine metabolic process
IB64_RS22105	COG2832	Protein of unknown function (DUF454)
IB64_RS22110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IB64_RS22125	COG3142	Participates in the control of copper homeostasis
IB64_RS22130	COG1418	mRNA catabolic process
IB64_RS22155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IB64_RS22170	COG4771	TonB-dependent receptor
IB64_RS22210	COG3340	Belongs to the peptidase S51 family
IB64_RS22215	COG2378	regulation of single-species biofilm formation
IB64_RS22270	COG1505	serine-type exopeptidase activity
IB64_RS22300	COG0617	tRNA 3'-terminal CCA addition
IB64_RS22300	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IB64_RS22300	COG0517	IMP dehydrogenase activity
IB64_RS22310	COG1126	abc transporter atp-binding protein
IB64_RS22320	COG1278	Cold shock
IB64_RS22350	COG0582	viral genome integration into host DNA
IB64_RS22405	COG1215	transferase activity, transferring glycosyl groups
IB64_RS22415	COG1216	Glycosyl transferase, family 2
IB64_RS22435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IB64_RS22450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IB64_RS22460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IB64_RS22495	COG0776	regulation of translation
IB64_RS22505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IB64_RS22540	COG0632	four-way junction helicase activity
IB64_RS22545	COG0673	inositol 2-dehydrogenase activity
IB64_RS22550	COG1272	protein, Hemolysin III
IB64_RS22555	COG1328	CTP reductase activity
IB64_RS22565	COG2814	Major facilitator Superfamily
IB64_RS22575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IB64_RS22585	COG0750	zinc metalloprotease
IB64_RS22590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IB64_RS22600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IB64_RS22605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IB64_RS22615	COG1214	PFAM Peptidase M22, glycoprotease
IB64_RS22620	COG2205	protein histidine kinase activity
IB64_RS22620	COG2198	Histidine kinase
IB64_RS22620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IB64_RS22620	COG0784	Response regulator, receiver
IB64_RS22635	COG0194	GDP metabolic process
IB64_RS22640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IB64_RS22645	COG1408	metallophosphoesterase
IB64_RS22650	COG1575	Belongs to the MenA family. Type 1 subfamily
IB64_RS22655	COG1088	dTDP-glucose 4,6-dehydratase activity
IB64_RS22660	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IB64_RS22670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IB64_RS22680	COG2204	response regulator
IB64_RS22685	COG0488	(ABC) transporter
IB64_RS22745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IB64_RS22750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IB64_RS22760	COG1522	sequence-specific DNA binding
IB64_RS22785	COG0811	peptide transport
IB64_RS22795	COG0084	hydrolase, TatD family'
IB64_RS22810	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IB64_RS22815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IB64_RS22820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IB64_RS22825	COG0205	6-phosphofructokinase activity
IB64_RS22845	COG0372	Belongs to the citrate synthase family
IB64_RS22850	COG0538	isocitrate dehydrogenase activity
IB64_RS22860	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IB64_RS22870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IB64_RS22895	COG0129	dihydroxy-acid dehydratase activity
IB64_RS22915	COG2885	chlorophyll binding
IB64_RS22935	COG3681	Belongs to the UPF0597 family
IB64_RS22970	COG3119	arylsulfatase activity
IB64_RS22980	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IB64_RS22990	COG0702	epimerase
IB64_RS22995	COG4771	TonB-dependent receptor
IB64_RS23010	COG0702	epimerase
IB64_RS23015	COG1629	transport
IB64_RS23015	COG4206	TonB-dependent receptor
IB64_RS23035	COG4771	TonB-dependent receptor
IB64_RS23065	COG1012	belongs to the aldehyde dehydrogenase family
IB64_RS23090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IB64_RS23090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IB64_RS23095	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IB64_RS23140	COG1752	Esterase of the alpha-beta hydrolase superfamily
IB64_RS23150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IB64_RS23155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IB64_RS23160	COG0166	Belongs to the GPI family
IB64_RS23380	COG2205	protein histidine kinase activity
IB64_RS23380	COG0784	Response regulator, receiver
IB64_RS23380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IB64_RS23380	COG2198	Histidine kinase
IB64_RS23400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IB64_RS23400	COG0551	DNA topoisomerase type I activity
IB64_RS23440	COG4974	Belongs to the 'phage' integrase family
IB64_RS23450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IB64_RS23620	COG0863	Belongs to the N(4) N(6)-methyltransferase family
IB64_RS23720	COG2502	aspartate--ammonia ligase
IB64_RS23725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IB64_RS23740	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IB64_RS23765	COG0860	N-Acetylmuramoyl-L-alanine amidase