locus-tag	class	description
F0R78_RS00005	COG0739	heme binding
F0R78_RS00005	COG0741	lytic transglycosylase activity
F0R78_RS00005	COG1196	nuclear chromosome segregation
F0R78_RS00130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F0R78_RS00145	COG4771	TonB-dependent receptor
F0R78_RS00155	COG3119	arylsulfatase activity
F0R78_RS00165	COG5002	protein histidine kinase activity
F0R78_RS00190	COG4206	TonB-dependent receptor
F0R78_RS00190	COG1629	transport
F0R78_RS00255	COG1192	Involved in chromosome partitioning
F0R78_RS00260	COG3177	Filamentation induced by cAMP protein fic
F0R78_RS00275	COG4974	Belongs to the 'phage' integrase family
F0R78_RS00375	COG0443	Heat shock 70 kDa protein
F0R78_RS00395	COG0528	UMP kinase activity
F0R78_RS00400	COG0534	Mate efflux family protein
F0R78_RS00435	COG0792	nuclease activity
F0R78_RS00460	COG1183	phosphatidylcholine synthase activity
F0R78_RS00465	COG0688	phosphatidylethanolamine metabolic process
F0R78_RS00475	COG3118	belongs to the thioredoxin family
F0R78_RS00495	COG1136	(ABC) transporter
F0R78_RS00495	COG0577	efflux transmembrane transporter activity
F0R78_RS00540	COG2205	protein histidine kinase activity
F0R78_RS00570	COG0714	Associated with various cellular activities
F0R78_RS00585	COG0802	atpase or kinase
F0R78_RS00590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0R78_RS00600	COG2234	aminopeptidase activity
F0R78_RS00625	COG1629	transport
F0R78_RS00645	COG3250	beta-galactosidase activity
F0R78_RS00650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F0R78_RS00660	COG2205	protein histidine kinase activity
F0R78_RS00660	COG0784	Response regulator, receiver
F0R78_RS00685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F0R78_RS00700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0R78_RS00705	COG0742	ribosomal rna small subunit methyltransferase
F0R78_RS00730	COG4771	TonB-dependent receptor
F0R78_RS00740	COG3537	Alpha-1,2-mannosidase
F0R78_RS00755	COG3537	Alpha-1,2-mannosidase
F0R78_RS00765	COG2814	Major facilitator Superfamily
F0R78_RS00780	COG0739	heme binding
F0R78_RS00790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0R78_RS00795	COG3942	CHAP domain
F0R78_RS00795	COG1388	LysM domain
F0R78_RS00805	COG1475	DNA binding
F0R78_RS00810	COG1192	Involved in chromosome partitioning
F0R78_RS00820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F0R78_RS00825	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0R78_RS00835	COG4589	Belongs to the CDS family
F0R78_RS00840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F0R78_RS00845	COG0799	negative regulation of ribosome biogenesis
F0R78_RS00860	COG2239	Acts as a magnesium transporter
F0R78_RS00865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F0R78_RS00875	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0R78_RS00955	COG0668	transmembrane transport
F0R78_RS00960	COG0662	Cupin 2, conserved barrel domain protein
F0R78_RS00960	COG2207	Transcriptional regulator
F0R78_RS01045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F0R78_RS01050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS01060	COG1086	Polysaccharide biosynthesis protein
F0R78_RS01075	COG0297	glycogen (starch) synthase activity
F0R78_RS01080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0R78_RS01090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0R78_RS01130	COG0667	Aldo Keto reductase
F0R78_RS01135	COG1472	Belongs to the glycosyl hydrolase 3 family
F0R78_RS01140	COG4771	TonB-dependent receptor
F0R78_RS01145	COG0702	epimerase
F0R78_RS01190	COG5012	cobalamin binding
F0R78_RS01205	COG4124	Belongs to the glycosyl hydrolase 26 family
F0R78_RS01210	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
F0R78_RS01215	COG2211	Major facilitator Superfamily
F0R78_RS01220	COG2942	2-epimerase
F0R78_RS01270	COG0784	Response regulator, receiver
F0R78_RS01270	COG2205	protein histidine kinase activity
F0R78_RS01270	COG5002	protein histidine kinase activity
F0R78_RS01280	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0R78_RS01285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0R78_RS01290	COG0713	ATP synthesis coupled electron transport
F0R78_RS01295	COG0839	Belongs to the complex I subunit 6 family
F0R78_RS01305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F0R78_RS01310	COG0649	NAD binding
F0R78_RS01310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0R78_RS01315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0R78_RS01320	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0R78_RS01330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0R78_RS01335	COG0569	domain protein
F0R78_RS01340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0R78_RS01350	COG1073	alpha beta
F0R78_RS01360	COG0546	phosphoglycolate phosphatase activity
F0R78_RS01365	COG3119	arylsulfatase activity
F0R78_RS01380	COG3119	arylsulfatase activity
F0R78_RS01390	COG4771	TonB-dependent receptor
F0R78_RS01395	COG2205	protein histidine kinase activity
F0R78_RS01395	COG3292	Two component regulator propeller
F0R78_RS01395	COG0745	RESPONSE REGULATOR receiver
F0R78_RS01400	COG2271	Major facilitator Superfamily
F0R78_RS01425	COG0805	protein transport
F0R78_RS01430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0R78_RS01435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0R78_RS01475	COG4585	Histidine kinase
F0R78_RS01490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0R78_RS01500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0R78_RS01505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F0R78_RS01505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0R78_RS01510	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0R78_RS01515	COG1078	dGTPase activity
F0R78_RS01520	COG0284	orotidine-5'-phosphate decarboxylase activity
F0R78_RS01525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F0R78_RS01530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0R78_RS01545	COG1704	LemA family
F0R78_RS01560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0R78_RS01565	COG2226	methyltransferase
F0R78_RS01570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0R78_RS01575	COG1702	phosphate starvation-inducible protein PhoH
F0R78_RS01585	COG2268	Band 7 protein
F0R78_RS01595	COG5434	Belongs to the glycosyl hydrolase 28 family
F0R78_RS01605	COG0101	tRNA pseudouridine synthase activity
F0R78_RS01625	COG3250	beta-galactosidase activity
F0R78_RS01630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F0R78_RS01655	COG0457	Tetratricopeptide repeat
F0R78_RS01660	COG2814	Major facilitator Superfamily
F0R78_RS01690	COG4206	TonB-dependent receptor
F0R78_RS01690	COG1629	transport
F0R78_RS01710	COG4206	TonB-dependent receptor
F0R78_RS01710	COG1629	transport
F0R78_RS01720	COG4771	TonB-dependent receptor
F0R78_RS01730	COG4206	TonB-dependent receptor
F0R78_RS01730	COG1629	transport
F0R78_RS01735	COG0702	epimerase
F0R78_RS01740	COG0673	inositol 2-dehydrogenase activity
F0R78_RS01785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0R78_RS01790	COG0793	Belongs to the peptidase S41A family
F0R78_RS01795	COG2131	deaminase
F0R78_RS01805	COG0339	signal peptide processing
F0R78_RS01815	COG1970	mechanosensitive ion channel activity
F0R78_RS01820	COG0519	Catalyzes the synthesis of GMP from XMP
F0R78_RS01820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0R78_RS01830	COG4206	TonB-dependent receptor
F0R78_RS01830	COG1629	transport
F0R78_RS01840	COG1629	transport
F0R78_RS01840	COG4206	TonB-dependent receptor
F0R78_RS01845	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0R78_RS01865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F0R78_RS01895	COG1242	4 iron, 4 sulfur cluster binding
F0R78_RS01905	COG0363	glucosamine-6-phosphate deaminase activity
F0R78_RS01915	COG0009	L-threonylcarbamoyladenylate synthase
F0R78_RS01925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0R78_RS01930	COG0561	phosphatase activity
F0R78_RS01935	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F0R78_RS01940	COG2873	o-acetylhomoserine
F0R78_RS01995	COG0297	glycogen (starch) synthase activity
F0R78_RS02000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F0R78_RS02005	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F0R78_RS02010	COG0543	2 iron, 2 sulfur cluster binding
F0R78_RS02020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0R78_RS02030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F0R78_RS02035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F0R78_RS02055	COG0546	phosphoglycolate phosphatase activity
F0R78_RS02060	COG0791	NLP P60 protein
F0R78_RS02075	COG0612	Peptidase, M16
F0R78_RS02080	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F0R78_RS02085	COG1597	lipid kinase activity
F0R78_RS02090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0R78_RS02100	COG1136	(ABC) transporter
F0R78_RS02120	COG2211	Major facilitator Superfamily
F0R78_RS02135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0R78_RS02150	COG1674	ftsk spoiiie
F0R78_RS02160	COG0492	ferredoxin-NADP+ reductase activity
F0R78_RS02165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS02210	COG1595	DNA-templated transcription, initiation
F0R78_RS02225	COG3956	TIGRFAM MazG family protein
F0R78_RS02235	COG0525	valine-tRNA ligase activity
F0R78_RS02240	COG2198	Histidine kinase
F0R78_RS02240	COG0784	Response regulator, receiver
F0R78_RS02240	COG2205	protein histidine kinase activity
F0R78_RS02265	COG4771	TonB-dependent receptor
F0R78_RS02280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F0R78_RS02295	COG1629	transport
F0R78_RS02295	COG4206	TonB-dependent receptor
F0R78_RS02300	COG0702	epimerase
F0R78_RS02305	COG3119	arylsulfatase activity
F0R78_RS02310	COG3119	arylsulfatase activity
F0R78_RS02330	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
F0R78_RS02345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F0R78_RS02365	COG1253	flavin adenine dinucleotide binding
F0R78_RS02375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F0R78_RS02385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F0R78_RS02425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F0R78_RS02435	COG2226	methyltransferase
F0R78_RS02480	COG1086	Polysaccharide biosynthesis protein
F0R78_RS02520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS02525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0R78_RS02540	COG4771	TonB-dependent receptor
F0R78_RS02550	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F0R78_RS02555	COG0563	adenylate kinase activity
F0R78_RS02560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0R78_RS02565	COG1496	oxidoreductase activity
F0R78_RS02585	COG2706	6-phosphogluconolactonase activity
F0R78_RS02625	COG1288	antiporter activity
F0R78_RS02645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0R78_RS02665	COG0564	pseudouridine synthase activity
F0R78_RS02680	COG1501	Belongs to the glycosyl hydrolase 31 family
F0R78_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
F0R78_RS02755	COG4942	peptidase
F0R78_RS02800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F0R78_RS02805	COG5002	protein histidine kinase activity
F0R78_RS02805	COG0784	Response regulator, receiver
F0R78_RS02810	COG2910	NAD(P)H-binding
F0R78_RS02815	COG2176	DNA-directed DNA polymerase activity
F0R78_RS02825	COG4864	UPF0365 protein
F0R78_RS02840	COG0037	tRNA processing
F0R78_RS02860	COG1477	protein flavinylation
F0R78_RS02865	COG1971	Probably functions as a manganese efflux pump
F0R78_RS02880	COG0463	Glycosyl transferase, family 2
F0R78_RS02895	COG0148	phosphopyruvate hydratase activity
F0R78_RS02905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0R78_RS02910	COG1082	Xylose isomerase domain protein TIM barrel
F0R78_RS02935	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F0R78_RS02940	COG0193	aminoacyl-tRNA hydrolase activity
F0R78_RS02945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F0R78_RS02955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0R78_RS02960	COG1862	Preprotein translocase
F0R78_RS02985	COG0542	response to heat
F0R78_RS02995	COG0583	DNA-binding transcription factor activity
F0R78_RS03000	COG2855	membrane
F0R78_RS03015	COG1595	DNA-templated transcription, initiation
F0R78_RS03030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F0R78_RS03050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0R78_RS03075	COG0443	Heat shock 70 kDa protein
F0R78_RS03085	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F0R78_RS03090	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
F0R78_RS03095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0R78_RS03115	COG1501	Belongs to the glycosyl hydrolase 31 family
F0R78_RS03145	COG4206	TonB-dependent receptor
F0R78_RS03145	COG1629	transport
F0R78_RS03155	COG1408	metallophosphoesterase
F0R78_RS03160	COG1368	sulfuric ester hydrolase activity
F0R78_RS03170	COG3634	alkyl hydroperoxide reductase activity
F0R78_RS03210	COG1760	l-serine dehydratase
F0R78_RS03215	COG0598	Magnesium transport protein CorA
F0R78_RS03220	COG1193	negative regulation of DNA recombination
F0R78_RS03315	COG1063	alcohol dehydrogenase
F0R78_RS03330	COG3119	arylsulfatase activity
F0R78_RS03335	COG0784	Response regulator, receiver
F0R78_RS03335	COG5002	protein histidine kinase activity
F0R78_RS03340	COG2855	membrane
F0R78_RS03345	COG2217	Heavy metal translocating P-type atpase
F0R78_RS03355	COG2885	chlorophyll binding
F0R78_RS03365	COG3189	MarR family transcriptional regulator
F0R78_RS03370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F0R78_RS03375	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0R78_RS03380	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0R78_RS03400	COG4651	solute:proton antiporter activity
F0R78_RS03400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0R78_RS03405	COG1280	lysine exporter protein (LysE YggA)
F0R78_RS03420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F0R78_RS03435	COG0561	phosphatase activity
F0R78_RS03440	COG1169	isochorismate synthase
F0R78_RS03445	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F0R78_RS03460	COG4948	Mandelate Racemase Muconate Lactonizing
F0R78_RS03475	COG1082	Xylose isomerase domain protein TIM barrel
F0R78_RS03490	COG4771	TonB-dependent receptor
F0R78_RS03520	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
F0R78_RS03525	COG0783	Belongs to the Dps family
F0R78_RS03530	COG0583	DNA-binding transcription factor activity
F0R78_RS03550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0R78_RS03600	COG1253	flavin adenine dinucleotide binding
F0R78_RS03605	COG0501	Belongs to the peptidase M48B family
F0R78_RS03635	COG2873	o-acetylhomoserine
F0R78_RS03640	COG0482	sulfurtransferase activity
F0R78_RS03645	COG2197	response regulator
F0R78_RS03655	COG1757	Na H antiporter
F0R78_RS03670	COG2814	Major facilitator Superfamily
F0R78_RS03675	COG4953	penicillin-binding protein 1C
F0R78_RS03680	COG2373	Large extracellular alpha-helical protein
F0R78_RS03690	COG1918	ferrous iron import across plasma membrane
F0R78_RS03690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F0R78_RS03810	COG1086	Polysaccharide biosynthesis protein
F0R78_RS03815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0R78_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
F0R78_RS03845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F0R78_RS03875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F0R78_RS03880	COG0463	Glycosyl transferase, family 2
F0R78_RS03880	COG1216	Glycosyl transferase, family 2
F0R78_RS03890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0R78_RS03895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0R78_RS03905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0R78_RS03910	COG0490	domain, Protein
F0R78_RS03910	COG0471	metal ion transport
F0R78_RS03925	COG0346	lactoylglutathione lyase activity
F0R78_RS03940	COG0259	pyridoxamine-phosphate oxidase activity
F0R78_RS03945	COG1741	Belongs to the pirin family
F0R78_RS03965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0R78_RS03995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F0R78_RS04005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F0R78_RS04020	COG1595	DNA-templated transcription, initiation
F0R78_RS04045	COG0686	Belongs to the AlaDH PNT family
F0R78_RS04060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0R78_RS04080	COG1629	transport
F0R78_RS04095	COG3345	alpha-galactosidase
F0R78_RS04125	COG0488	(ABC) transporter
F0R78_RS04130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0R78_RS04135	COG3059	membrane
F0R78_RS04140	COG2207	Transcriptional regulator
F0R78_RS04140	COG1917	Cupin 2, conserved barrel domain protein
F0R78_RS04145	COG0295	cytidine deaminase activity
F0R78_RS04150	COG1705	Flagellar rod assembly protein muramidase FlgJ
F0R78_RS04150	COG1388	LysM domain
F0R78_RS04165	COG0577	efflux transmembrane transporter activity
F0R78_RS04170	COG0577	efflux transmembrane transporter activity
F0R78_RS04175	COG0577	efflux transmembrane transporter activity
F0R78_RS04185	COG0577	efflux transmembrane transporter activity
F0R78_RS04185	COG1136	(ABC) transporter
F0R78_RS04200	COG1136	(ABC) transporter
F0R78_RS04215	COG1136	(ABC) transporter
F0R78_RS04235	COG2205	protein histidine kinase activity
F0R78_RS04250	COG2204	response regulator
F0R78_RS04275	COG0732	type I restriction modification DNA specificity domain
F0R78_RS04280	COG4974	Belongs to the 'phage' integrase family
F0R78_RS04290	COG0732	type I restriction modification DNA specificity domain
F0R78_RS04305	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F0R78_RS04420	COG1088	dTDP-glucose 4,6-dehydratase activity
F0R78_RS04430	COG0656	L-ascorbic acid biosynthetic process
F0R78_RS04450	COG1215	transferase activity, transferring glycosyl groups
F0R78_RS04470	COG1216	Glycosyl transferase, family 2
F0R78_RS04480	COG0438	transferase activity, transferring glycosyl groups
F0R78_RS04490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS04495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0R78_RS04500	COG1530	ribonuclease E activity
F0R78_RS04515	COG3119	arylsulfatase activity
F0R78_RS04520	COG0629	single-stranded DNA binding
F0R78_RS04580	COG4206	TonB-dependent receptor
F0R78_RS04605	COG5002	protein histidine kinase activity
F0R78_RS04610	COG0745	RESPONSE REGULATOR receiver
F0R78_RS04640	COG0488	(ABC) transporter
F0R78_RS04655	COG5492	domain, Protein
F0R78_RS04665	COG0436	Aminotransferase
F0R78_RS04670	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0R78_RS04675	COG1215	transferase activity, transferring glycosyl groups
F0R78_RS04680	COG0628	permease
F0R78_RS04685	COG3852	Histidine kinase
F0R78_RS04700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS04705	COG1136	(ABC) transporter
F0R78_RS04705	COG0577	efflux transmembrane transporter activity
F0R78_RS04710	COG0577	efflux transmembrane transporter activity
F0R78_RS04715	COG1252	NADH dehydrogenase
F0R78_RS04745	COG4771	TonB-dependent receptor
F0R78_RS04755	COG1620	l-lactate permease
F0R78_RS04760	COG2885	chlorophyll binding
F0R78_RS04760	COG3047	cAMP biosynthetic process
F0R78_RS04770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0R78_RS04775	COG0439	Biotin carboxylase
F0R78_RS04780	COG0511	ligase activity, forming carbon-carbon bonds
F0R78_RS04785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0R78_RS04830	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0R78_RS04835	COG0022	dehydrogenase e1 component
F0R78_RS04840	COG0716	FMN binding
F0R78_RS04845	COG2264	protein methyltransferase activity
F0R78_RS04900	COG0590	tRNA wobble adenosine to inosine editing
F0R78_RS04930	COG0673	inositol 2-dehydrogenase activity
F0R78_RS04940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F0R78_RS04980	COG0698	ribose 5-phosphate isomerase
F0R78_RS04985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0R78_RS04990	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0R78_RS05005	COG1482	cell wall glycoprotein biosynthetic process
F0R78_RS05025	COG0513	Belongs to the DEAD box helicase family
F0R78_RS05030	COG4221	oxidoreductase activity
F0R78_RS05045	COG3250	beta-galactosidase activity
F0R78_RS05055	COG0471	metal ion transport
F0R78_RS05055	COG3273	potassium ion transport
F0R78_RS05060	COG0529	Catalyzes the synthesis of activated sulfate
F0R78_RS05065	COG0175	sulfate reduction
F0R78_RS05070	COG2895	sulfate adenylyltransferase (ATP) activity
F0R78_RS05110	COG4974	Belongs to the 'phage' integrase family
F0R78_RS05135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0R78_RS05140	COG0242	peptide deformylase activity
F0R78_RS05155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F0R78_RS05160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F0R78_RS05165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0R78_RS05170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0R78_RS05180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0R78_RS05185	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
F0R78_RS05200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0R78_RS05250	COG1940	carbohydrate kinase activity
F0R78_RS05255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0R78_RS05265	COG2271	Major facilitator Superfamily
F0R78_RS05270	COG2731	YhcH YjgK YiaL family protein
F0R78_RS05275	COG1629	transport
F0R78_RS05280	COG0702	epimerase
F0R78_RS05300	COG1629	transport
F0R78_RS05305	COG0702	epimerase
F0R78_RS05320	COG4771	TonB-dependent receptor
F0R78_RS05325	COG0702	epimerase
F0R78_RS05330	COG0702	epimerase
F0R78_RS05335	COG1629	transport
F0R78_RS05335	COG4206	TonB-dependent receptor
F0R78_RS05340	COG1629	transport
F0R78_RS05340	COG4206	TonB-dependent receptor
F0R78_RS05360	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS05380	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS05390	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS05395	COG3537	Alpha-1,2-mannosidase
F0R78_RS05400	COG3250	beta-galactosidase activity
F0R78_RS05405	COG1629	transport
F0R78_RS05405	COG4206	TonB-dependent receptor
F0R78_RS05410	COG0702	epimerase
F0R78_RS05420	COG0484	heat shock protein binding
F0R78_RS05425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0R78_RS05430	COG0488	(ABC) transporter
F0R78_RS05435	COG1595	DNA-templated transcription, initiation
F0R78_RS05460	COG0823	Involved in the tonB-independent uptake of proteins
F0R78_RS05470	COG4206	TonB-dependent receptor
F0R78_RS05470	COG1629	transport
F0R78_RS05480	COG3537	Alpha-1,2-mannosidase
F0R78_RS05485	COG3568	Endonuclease Exonuclease Phosphatase
F0R78_RS05490	COG1785	Belongs to the alkaline phosphatase family
F0R78_RS05510	COG2207	Transcriptional regulator
F0R78_RS05510	COG1609	Transcriptional regulator
F0R78_RS05515	COG2183	response to ionizing radiation
F0R78_RS05590	COG2885	chlorophyll binding
F0R78_RS05705	COG2183	response to ionizing radiation
F0R78_RS05715	COG0737	Belongs to the 5'-nucleotidase family
F0R78_RS05720	COG1956	GAF domain-containing protein
F0R78_RS05730	COG4771	TonB-dependent receptor
F0R78_RS05755	COG0534	Mate efflux family protein
F0R78_RS05770	COG0534	Mate efflux family protein
F0R78_RS05780	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
F0R78_RS05790	COG0318	PFAM AMP-dependent synthetase and ligase
F0R78_RS05795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS05800	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F0R78_RS05840	COG2076	Multidrug Resistance protein
F0R78_RS05845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0R78_RS05850	COG0463	Glycosyl transferase, family 2
F0R78_RS05855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS05860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0R78_RS05870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0R78_RS05880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0R78_RS05885	COG3475	LICD family
F0R78_RS05890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS05895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0R78_RS05900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0R78_RS05915	COG2089	acid synthase
F0R78_RS05920	COG1083	cytidylyl-transferase
F0R78_RS05925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F0R78_RS05945	COG0438	transferase activity, transferring glycosyl groups
F0R78_RS05950	COG1215	transferase activity, transferring glycosyl groups
F0R78_RS05955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS05960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0R78_RS06005	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
F0R78_RS06010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F0R78_RS06015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F0R78_RS06020	COG0363	glucosamine-6-phosphate deaminase activity
F0R78_RS06040	COG4413	Urea transporter
F0R78_RS06165	COG0629	single-stranded DNA binding
F0R78_RS06210	COG1475	DNA binding
F0R78_RS06365	COG1595	DNA-templated transcription, initiation
F0R78_RS06445	COG3279	Response regulator of the LytR AlgR family
F0R78_RS06455	COG1136	(ABC) transporter
F0R78_RS06455	COG0577	efflux transmembrane transporter activity
F0R78_RS06460	COG1136	(ABC) transporter
F0R78_RS06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS06490	COG4884	unkown
F0R78_RS06490	COG3831	ATPase activity
F0R78_RS06505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0R78_RS06515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0R78_RS06520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F0R78_RS06525	COG3250	beta-galactosidase activity
F0R78_RS06560	COG1704	LemA family
F0R78_RS06565	COG1595	DNA-templated transcription, initiation
F0R78_RS06580	COG4206	TonB-dependent receptor
F0R78_RS06580	COG1629	transport
F0R78_RS06590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0R78_RS06595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F0R78_RS06595	COG2885	chlorophyll binding
F0R78_RS06605	COG0697	spore germination
F0R78_RS06655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0R78_RS06680	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F0R78_RS06685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0R78_RS06690	COG2814	Major facilitator Superfamily
F0R78_RS06695	COG4771	TonB-dependent receptor
F0R78_RS06735	COG4771	TonB-dependent receptor
F0R78_RS06900	COG0542	response to heat
F0R78_RS06930	COG0156	8-amino-7-oxononanoate synthase activity
F0R78_RS06965	COG4974	Belongs to the 'phage' integrase family
F0R78_RS07035	COG0488	(ABC) transporter
F0R78_RS07055	COG2198	Histidine kinase
F0R78_RS07055	COG2205	protein histidine kinase activity
F0R78_RS07055	COG0784	Response regulator, receiver
F0R78_RS07055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0R78_RS07075	COG0438	transferase activity, transferring glycosyl groups
F0R78_RS07090	COG2244	polysaccharide biosynthetic process
F0R78_RS07095	COG0438	transferase activity, transferring glycosyl groups
F0R78_RS07105	COG1215	transferase activity, transferring glycosyl groups
F0R78_RS07135	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0R78_RS07140	COG1805	sodium ion transport
F0R78_RS07145	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0R78_RS07170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0R78_RS07175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0R78_RS07185	COG0545	Peptidyl-prolyl cis-trans isomerase
F0R78_RS07190	COG1739	Uncharacterized protein family UPF0029
F0R78_RS07200	COG0778	Nitroreductase
F0R78_RS07205	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0R78_RS07205	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0R78_RS07210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0R78_RS07240	COG2217	Heavy metal translocating P-type atpase
F0R78_RS07305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0R78_RS07310	COG1755	Isoprenylcysteine carboxyl methyltransferase
F0R78_RS07325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F0R78_RS07340	COG1678	Uncharacterized ACR, COG1678
F0R78_RS07365	COG0667	Aldo Keto reductase
F0R78_RS07375	COG0656	L-ascorbic acid biosynthetic process
F0R78_RS07385	COG0656	L-ascorbic acid biosynthetic process
F0R78_RS07400	COG0534	Mate efflux family protein
F0R78_RS07405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F0R78_RS07425	COG2311	Membrane
F0R78_RS07430	COG0667	Aldo Keto reductase
F0R78_RS07515	COG4771	TonB-dependent receptor
F0R78_RS07550	COG1309	transcriptional regulator
F0R78_RS07565	COG1132	(ABC) transporter
F0R78_RS07575	COG2205	protein histidine kinase activity
F0R78_RS07575	COG3850	Histidine kinase
F0R78_RS07575	COG4999	Histidine kinase
F0R78_RS07575	COG3437	response regulator, receiver
F0R78_RS07590	COG1522	sequence-specific DNA binding
F0R78_RS07610	COG3969	phosphoadenosine phosphosulfate
F0R78_RS07615	COG1475	DNA binding
F0R78_RS07665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS07670	COG0745	RESPONSE REGULATOR receiver
F0R78_RS07685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS07695	COG4206	TonB-dependent receptor
F0R78_RS07695	COG1629	transport
F0R78_RS07705	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F0R78_RS07725	COG1022	Amp-dependent synthetase and ligase
F0R78_RS07730	COG3263	regulation of cellular component size
F0R78_RS07740	COG1151	hydroxylamine reductase activity
F0R78_RS07775	COG1136	(ABC) transporter
F0R78_RS07775	COG0577	efflux transmembrane transporter activity
F0R78_RS07790	COG0534	Mate efflux family protein
F0R78_RS07795	COG1011	Hydrolase
F0R78_RS07800	COG0167	dihydroorotate dehydrogenase activity
F0R78_RS07810	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F0R78_RS07825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0R78_RS07855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0R78_RS07865	COG0356	it plays a direct role in the translocation of protons across the membrane
F0R78_RS07870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0R78_RS07875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0R78_RS07880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0R78_RS07885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0R78_RS07890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F0R78_RS07895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0R78_RS07900	COG3118	belongs to the thioredoxin family
F0R78_RS07920	COG0745	RESPONSE REGULATOR receiver
F0R78_RS07925	COG5002	protein histidine kinase activity
F0R78_RS07960	COG1120	ATPase activity
F0R78_RS07965	COG1091	dTDP-4-dehydrorhamnose reductase activity
F0R78_RS07995	COG2205	protein histidine kinase activity
F0R78_RS08000	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F0R78_RS08010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0R78_RS08025	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
F0R78_RS08030	COG0540	Belongs to the ATCase OTCase family
F0R78_RS08040	COG2431	L-lysine efflux transmembrane transporter activity
F0R78_RS08070	COG2837	iron assimilation
F0R78_RS08085	COG1629	transport
F0R78_RS08085	COG4206	TonB-dependent receptor
F0R78_RS08105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F0R78_RS08125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F0R78_RS08145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0R78_RS08150	COG2205	protein histidine kinase activity
F0R78_RS08380	COG0629	single-stranded DNA binding
F0R78_RS08385	COG0358	DNA primase activity
F0R78_RS08480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F0R78_RS08490	COG0656	L-ascorbic acid biosynthetic process
F0R78_RS08525	COG0582	viral genome integration into host DNA
F0R78_RS08530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0R78_RS08535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0R78_RS08550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F0R78_RS08560	COG0673	inositol 2-dehydrogenase activity
F0R78_RS08575	COG2223	nitrite transmembrane transporter activity
F0R78_RS08595	COG0671	phosphoesterase, PA-phosphatase related
F0R78_RS08615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F0R78_RS08620	COG0045	succinate-CoA ligase (ADP-forming) activity
F0R78_RS08625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F0R78_RS08630	COG0351	phosphomethylpyrimidine kinase
F0R78_RS08640	COG1070	Carbohydrate kinase
F0R78_RS08650	COG0477	Major facilitator Superfamily
F0R78_RS08650	COG2814	Major facilitator Superfamily
F0R78_RS08660	COG3153	acetyltransferase
F0R78_RS08660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0R78_RS08665	COG0450	alkyl hydroperoxide reductase
F0R78_RS08670	COG0724	RNA recognition motif
F0R78_RS08675	COG1858	cytochrome C peroxidase
F0R78_RS08680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0R78_RS08710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F0R78_RS08720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F0R78_RS08735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0R78_RS08800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F0R78_RS08810	COG1904	glucuronate isomerase
F0R78_RS08840	COG0513	Belongs to the DEAD box helicase family
F0R78_RS08845	COG0560	Phosphoserine phosphatase
F0R78_RS08845	COG3830	Belongs to the UPF0237 family
F0R78_RS08865	COG0343	queuine tRNA-ribosyltransferase activity
F0R78_RS08870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F0R78_RS08875	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F0R78_RS08995	COG0653	protein targeting
F0R78_RS09000	COG3935	DnaD domain protein
F0R78_RS09175	COG2205	protein histidine kinase activity
F0R78_RS09180	COG2204	response regulator
F0R78_RS09230	COG1136	(ABC) transporter
F0R78_RS09230	COG0577	efflux transmembrane transporter activity
F0R78_RS09240	COG0156	8-amino-7-oxononanoate synthase activity
F0R78_RS09245	COG1597	lipid kinase activity
F0R78_RS09250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0R78_RS09275	COG0577	efflux transmembrane transporter activity
F0R78_RS09275	COG1136	(ABC) transporter
F0R78_RS09300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F0R78_RS09330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0R78_RS09350	COG0543	2 iron, 2 sulfur cluster binding
F0R78_RS09355	COG0167	dihydroorotate dehydrogenase activity
F0R78_RS09365	COG0336	Belongs to the RNA methyltransferase TrmD family
F0R78_RS09375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0R78_RS09385	COG2315	Protein conserved in bacteria
F0R78_RS09415	COG0326	Molecular chaperone. Has ATPase activity
F0R78_RS09420	COG0542	response to heat
F0R78_RS09465	COG2304	oxidoreductase activity
F0R78_RS09480	COG0714	Associated with various cellular activities
F0R78_RS09485	COG1652	LysM domain
F0R78_RS09495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0R78_RS09500	COG0552	protein localization to endoplasmic reticulum
F0R78_RS09510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0R78_RS09515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0R78_RS09525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0R78_RS09540	COG0442	prolyl-tRNA aminoacylation
F0R78_RS09555	COG0793	Belongs to the peptidase S41A family
F0R78_RS09555	COG4946	Tricorn protease homolog
F0R78_RS09575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F0R78_RS09580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F0R78_RS09590	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F0R78_RS09600	COG1492	cobalamin metabolic process
F0R78_RS09660	COG1629	transport
F0R78_RS09660	COG4206	TonB-dependent receptor
F0R78_RS09665	COG0702	epimerase
F0R78_RS09680	COG2096	Adenosyltransferase
F0R78_RS09685	COG1797	cobyrinic acid a,c-diamide synthase activity
F0R78_RS09700	COG2966	Psort location CytoplasmicMembrane, score
F0R78_RS09715	COG4771	TonB-dependent receptor
F0R78_RS09725	COG4774	siderophore transport
F0R78_RS09735	COG1429	ligase activity, forming nitrogen-metal bonds
F0R78_RS09770	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F0R78_RS09840	COG0352	thiamine-phosphate diphosphorylase activity
F0R78_RS09845	COG2022	thiamine diphosphate biosynthetic process
F0R78_RS09850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F0R78_RS09870	COG0352	thiamine-phosphate diphosphorylase activity
F0R78_RS09885	COG0574	Belongs to the PEP-utilizing enzyme family
F0R78_RS09885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0R78_RS09890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0R78_RS09895	COG0564	pseudouridine synthase activity
F0R78_RS09910	COG0024	Methionine aminopeptidase
F0R78_RS09925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0R78_RS09935	COG0481	GTPase activity
F0R78_RS09955	COG0708	Exodeoxyribonuclease III
F0R78_RS09960	COG1914	H( )-stimulated, divalent metal cation uptake system
F0R78_RS09975	COG0217	transcriptional regulatory protein
F0R78_RS09980	COG0072	phenylalanine-tRNA ligase activity
F0R78_RS09980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0R78_RS09985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0R78_RS09990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS10015	COG1216	Glycosyl transferase, family 2
F0R78_RS10040	COG2089	acid synthase
F0R78_RS10050	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F0R78_RS10075	COG0305	Participates in initiation and elongation during chromosome replication
F0R78_RS10095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F0R78_RS10100	COG4657	Part of a membrane complex involved in electron transport
F0R78_RS10105	COG4660	Part of a membrane complex involved in electron transport
F0R78_RS10110	COG4659	FMN binding
F0R78_RS10115	COG4658	electron transport chain
F0R78_RS10120	COG4656	Part of a membrane complex involved in electron transport
F0R78_RS10150	COG0504	CTP synthase activity
F0R78_RS10160	COG0534	Mate efflux family protein
F0R78_RS10165	COG1506	peptidase
F0R78_RS10165	COG0823	Involved in the tonB-independent uptake of proteins
F0R78_RS10180	COG1695	Transcriptional regulator
F0R78_RS10195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0R78_RS10205	COG3942	CHAP domain
F0R78_RS10205	COG1388	LysM domain
F0R78_RS10235	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
F0R78_RS10245	COG0556	nucleotide-excision repair
F0R78_RS10255	COG2949	membrane
F0R78_RS10265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0R78_RS10275	COG3850	Histidine kinase
F0R78_RS10275	COG4999	Histidine kinase
F0R78_RS10275	COG2205	protein histidine kinase activity
F0R78_RS10275	COG3437	response regulator, receiver
F0R78_RS10285	COG0842	Transport permease protein
F0R78_RS10290	COG1131	(ABC) transporter
F0R78_RS10320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0R78_RS10325	COG0505	Belongs to the CarA family
F0R78_RS10335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0R78_RS10340	COG0367	asparagine synthase
F0R78_RS10365	COG0436	Aminotransferase
F0R78_RS10375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F0R78_RS10385	COG1979	alcohol dehydrogenase
F0R78_RS10405	COG0133	tryptophan synthase activity
F0R78_RS10410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0R78_RS10415	COG0512	Glutamine amidotransferase of anthranilate synthase
F0R78_RS10415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0R78_RS10425	COG0134	indole-3-glycerol-phosphate synthase activity
F0R78_RS10430	COG0135	phosphoribosylanthranilate isomerase activity
F0R78_RS10435	COG0159	tryptophan synthase activity
F0R78_RS10445	COG0252	asparaginase activity
F0R78_RS10460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0R78_RS10470	COG0110	maltose O-acetyltransferase activity
F0R78_RS10475	COG2197	response regulator
F0R78_RS10485	COG0138	bifunctional purine biosynthesis protein purh
F0R78_RS10490	COG0716	FMN binding
F0R78_RS10520	COG1858	cytochrome C peroxidase
F0R78_RS10530	COG4771	TonB-dependent receptor
F0R78_RS10545	COG2814	Major facilitator Superfamily
F0R78_RS10550	COG1566	PFAM secretion protein HlyD family protein
F0R78_RS10595	COG4771	TonB-dependent receptor
F0R78_RS10620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0R78_RS10625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0R78_RS10640	COG2966	Psort location CytoplasmicMembrane, score
F0R78_RS10645	COG3610	response to peptide
F0R78_RS10660	COG1609	Transcriptional regulator
F0R78_RS10670	COG1733	regulation of RNA biosynthetic process
F0R78_RS10680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0R78_RS10680	COG2198	Histidine kinase
F0R78_RS10680	COG2205	protein histidine kinase activity
F0R78_RS10680	COG0784	Response regulator, receiver
F0R78_RS10705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F0R78_RS10745	COG0228	four-way junction DNA binding
F0R78_RS10760	COG0724	RNA recognition motif
F0R78_RS10770	COG1177	transmembrane transport
F0R78_RS10775	COG1176	ABC-type spermidine putrescine transport system, permease component I
F0R78_RS10785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0R78_RS10795	COG0058	SHG alpha-glucan phosphorylase activity
F0R78_RS10805	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0R78_RS10825	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
F0R78_RS10880	COG0745	RESPONSE REGULATOR receiver
F0R78_RS10885	COG5002	protein histidine kinase activity
F0R78_RS10910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0R78_RS10920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0R78_RS10930	COG4948	Mandelate Racemase Muconate Lactonizing
F0R78_RS10945	COG1295	ribonuclease BN
F0R78_RS10955	COG0778	Nitroreductase
F0R78_RS10965	COG0704	Plays a role in the regulation of phosphate uptake
F0R78_RS10970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F0R78_RS10975	COG0581	inorganic phosphate transmembrane transporter activity
F0R78_RS10980	COG0573	inorganic phosphate transmembrane transporter activity
F0R78_RS10990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0R78_RS11015	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F0R78_RS11055	COG3023	N-Acetylmuramoyl-L-alanine amidase
F0R78_RS11085	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F0R78_RS11110	COG1216	Glycosyl transferase, family 2
F0R78_RS11125	COG1215	transferase activity, transferring glycosyl groups
F0R78_RS11130	COG1442	glycosyl transferase family 8
F0R78_RS11130	COG1216	Glycosyl transferase, family 2
F0R78_RS11150	COG1216	Glycosyl transferase, family 2
F0R78_RS11170	COG1216	Glycosyl transferase, family 2
F0R78_RS11170	COG1442	glycosyl transferase family 8
F0R78_RS11180	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F0R78_RS11230	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F0R78_RS11300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F0R78_RS11305	COG0167	dihydroorotate dehydrogenase activity
F0R78_RS11370	COG4191	Histidine kinase
F0R78_RS11370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0R78_RS11385	COG2172	sigma factor antagonist activity
F0R78_RS11395	COG2208	phosphoserine phosphatase activity
F0R78_RS11415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F0R78_RS11435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0R78_RS11440	COG0497	DNA recombination
F0R78_RS11450	COG2176	DNA-directed DNA polymerase activity
F0R78_RS11450	COG5002	protein histidine kinase activity
F0R78_RS11455	COG0592	DNA-directed DNA polymerase activity
F0R78_RS11470	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F0R78_RS11470	COG0321	lipoyl(octanoyl) transferase activity
F0R78_RS11485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS11495	COG0156	8-amino-7-oxononanoate synthase activity
F0R78_RS11595	COG0019	diaminopimelate decarboxylase activity
F0R78_RS11600	COG0527	aspartate kinase activity
F0R78_RS11605	COG2884	Cell division ATP-binding protein ftsE
F0R78_RS11610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F0R78_RS11610	COG0140	phosphoribosyl-ATP diphosphatase activity
F0R78_RS11615	COG0107	imidazoleglycerol-phosphate synthase activity
F0R78_RS11620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0R78_RS11815	COG4771	TonB-dependent receptor
F0R78_RS11820	COG0702	epimerase
F0R78_RS11840	COG3392	D12 class N6 adenine-specific DNA methyltransferase
F0R78_RS11850	COG1192	Involved in chromosome partitioning
F0R78_RS11880	COG1196	nuclear chromosome segregation
F0R78_RS11880	COG0741	lytic transglycosylase activity
F0R78_RS11880	COG0739	heme binding
F0R78_RS12065	COG3586	endonuclease activity
F0R78_RS12115	COG1472	Belongs to the glycosyl hydrolase 3 family
F0R78_RS12120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F0R78_RS12130	COG5012	cobalamin binding
F0R78_RS12140	COG1472	Belongs to the glycosyl hydrolase 3 family
F0R78_RS12145	COG0702	epimerase
F0R78_RS12150	COG4771	TonB-dependent receptor
F0R78_RS12165	COG0693	protein deglycase activity
F0R78_RS12180	COG0494	nUDIX hydrolase
F0R78_RS12185	COG1401	restriction endodeoxyribonuclease activity
F0R78_RS12205	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
F0R78_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
F0R78_RS12260	COG2207	Transcriptional regulator
F0R78_RS12275	COG1090	epimerase
F0R78_RS12305	COG0561	phosphatase activity
F0R78_RS12310	COG4206	TonB-dependent receptor
F0R78_RS12310	COG1629	transport
F0R78_RS12360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0R78_RS12370	COG0363	glucosamine-6-phosphate deaminase activity
F0R78_RS12420	COG1032	radical SAM domain protein
F0R78_RS12425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F0R78_RS12430	COG0463	Glycosyl transferase, family 2
F0R78_RS12435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0R78_RS12450	COG1410	methionine synthase
F0R78_RS12450	COG0646	methionine synthase
F0R78_RS12510	COG1408	metallophosphoesterase
F0R78_RS12515	COG1132	(ABC) transporter
F0R78_RS12520	COG1132	(ABC) transporter
F0R78_RS12535	COG0420	3'-5' exonuclease activity
F0R78_RS12555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0R78_RS12560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS12570	COG0681	Belongs to the peptidase S26 family
F0R78_RS12650	COG0641	radical SAM
F0R78_RS12655	COG3591	Belongs to the peptidase S1B family
F0R78_RS12660	COG3591	Belongs to the peptidase S1B family
F0R78_RS12695	COG1592	Rubrerythrin
F0R78_RS12695	COG1773	rubredoxin
F0R78_RS12705	COG3152	Membrane
F0R78_RS12710	COG0339	signal peptide processing
F0R78_RS12715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0R78_RS12715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0R78_RS12725	COG1629	transport
F0R78_RS12725	COG4206	TonB-dependent receptor
F0R78_RS12740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0R78_RS12740	COG0131	Imidazoleglycerol-phosphate dehydratase
F0R78_RS12745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0R78_RS12750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F0R78_RS12755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0R78_RS12765	COG1741	Belongs to the pirin family
F0R78_RS12770	COG4232	protein-disulfide reductase activity
F0R78_RS12780	COG0572	uridine kinase
F0R78_RS12790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0R78_RS12800	COG1410	methionine synthase
F0R78_RS12800	COG0646	methionine synthase
F0R78_RS12805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F0R78_RS12840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0R78_RS12850	COG1295	ribonuclease BN
F0R78_RS12880	COG2202	Pas domain
F0R78_RS12880	COG2205	protein histidine kinase activity
F0R78_RS12885	COG0534	Mate efflux family protein
F0R78_RS12890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F0R78_RS12900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0R78_RS12905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F0R78_RS12910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0R78_RS12970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F0R78_RS13010	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0R78_RS13020	COG0668	transmembrane transport
F0R78_RS13025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0R78_RS13035	COG3250	beta-galactosidase activity
F0R78_RS13040	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS13045	COG3119	arylsulfatase activity
F0R78_RS13050	COG3119	arylsulfatase activity
F0R78_RS13055	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS13065	COG1830	Aldolase
F0R78_RS13070	COG0588	phosphoglycerate mutase activity
F0R78_RS13080	COG1119	ATPase activity
F0R78_RS13085	COG3119	arylsulfatase activity
F0R78_RS13090	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS13100	COG1629	transport
F0R78_RS13100	COG4206	TonB-dependent receptor
F0R78_RS13110	COG1595	DNA-templated transcription, initiation
F0R78_RS13115	COG1523	belongs to the glycosyl hydrolase 13 family
F0R78_RS13120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F0R78_RS13145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F0R78_RS13155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F0R78_RS13160	COG0126	phosphoglycerate kinase activity
F0R78_RS13175	COG2311	Membrane
F0R78_RS13220	COG0424	maF-like protein
F0R78_RS13225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F0R78_RS13240	COG0778	Nitroreductase
F0R78_RS13245	COG0288	reversible hydration of carbon dioxide
F0R78_RS13260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0R78_RS13270	COG5016	pyruvate
F0R78_RS13270	COG0511	ligase activity, forming carbon-carbon bonds
F0R78_RS13275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F0R78_RS13290	COG0366	Alpha amylase catalytic
F0R78_RS13310	COG0191	fructose-bisphosphate aldolase activity
F0R78_RS13320	COG0254	rRNA binding
F0R78_RS13345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F0R78_RS13350	COG1629	transport
F0R78_RS13350	COG4206	TonB-dependent receptor
F0R78_RS13355	COG1609	Transcriptional regulator
F0R78_RS13365	COG1554	hydrolase, family 65, central catalytic
F0R78_RS13370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS13390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0R78_RS13390	COG0047	phosphoribosylformylglycinamidine synthase activity
F0R78_RS13395	COG0745	RESPONSE REGULATOR receiver
F0R78_RS13395	COG2205	protein histidine kinase activity
F0R78_RS13395	COG3292	Two component regulator propeller
F0R78_RS13410	COG1649	PFAM Uncharacterised BCR, COG1649
F0R78_RS13430	COG1966	Carbon starvation protein
F0R78_RS13440	COG1649	PFAM Uncharacterised BCR, COG1649
F0R78_RS13445	COG0784	Response regulator, receiver
F0R78_RS13445	COG2205	protein histidine kinase activity
F0R78_RS13485	COG2113	Glycine betaine
F0R78_RS13490	COG4176	ABC-type proline glycine betaine transport system permease component
F0R78_RS13510	COG3292	Two component regulator propeller
F0R78_RS13510	COG2205	protein histidine kinase activity
F0R78_RS13510	COG0745	RESPONSE REGULATOR receiver
F0R78_RS13515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F0R78_RS13515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F0R78_RS13525	COG1621	beta-fructofuranosidase activity
F0R78_RS13555	COG0738	Major facilitator superfamily
F0R78_RS13570	COG1752	Esterase of the alpha-beta hydrolase superfamily
F0R78_RS13575	COG0475	glutathione-regulated potassium exporter activity
F0R78_RS13600	COG3015	lipoprotein NlpE involved in copper resistance
F0R78_RS13620	COG4977	sequence-specific DNA binding
F0R78_RS13620	COG1917	Cupin 2, conserved barrel domain protein
F0R78_RS13650	COG4771	TonB-dependent receptor
F0R78_RS13655	COG0702	epimerase
F0R78_RS13670	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F0R78_RS13690	COG0484	heat shock protein binding
F0R78_RS13700	COG2194	sulfuric ester hydrolase activity
F0R78_RS13750	COG0028	Belongs to the TPP enzyme family
F0R78_RS13775	COG0459	protein refolding
F0R78_RS13780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0R78_RS13820	COG2326	polyphosphate kinase activity
F0R78_RS13865	COG3537	Alpha-1,2-mannosidase
F0R78_RS13870	COG1506	peptidase
F0R78_RS13870	COG0823	Involved in the tonB-independent uptake of proteins
F0R78_RS13905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0R78_RS13950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0R78_RS13960	COG0671	phosphoesterase, PA-phosphatase related
F0R78_RS13980	COG0702	epimerase
F0R78_RS13985	COG4771	TonB-dependent receptor
F0R78_RS14015	COG0463	Glycosyl transferase, family 2
F0R78_RS14030	COG0066	3-isopropylmalate dehydratase activity
F0R78_RS14040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F0R78_RS14045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0R78_RS14095	COG0616	signal peptide processing
F0R78_RS14105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F0R78_RS14110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F0R78_RS14125	COG4974	Belongs to the 'phage' integrase family
F0R78_RS14190	COG1373	ATPase (AAA superfamily
F0R78_RS14250	COG0546	phosphoglycolate phosphatase activity
F0R78_RS14265	COG2207	Transcriptional regulator
F0R78_RS14270	COG0745	RESPONSE REGULATOR receiver
F0R78_RS14270	COG2205	protein histidine kinase activity
F0R78_RS14270	COG3292	Two component regulator propeller
F0R78_RS14275	COG4948	Mandelate Racemase Muconate Lactonizing
F0R78_RS14295	COG0702	epimerase
F0R78_RS14300	COG4206	TonB-dependent receptor
F0R78_RS14300	COG1629	transport
F0R78_RS14330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0R78_RS14335	COG2207	Transcriptional regulator
F0R78_RS14335	COG1917	Cupin 2, conserved barrel domain protein
F0R78_RS14350	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
F0R78_RS14360	COG3011	Protein conserved in bacteria
F0R78_RS14370	COG1028	Short-chain dehydrogenase reductase Sdr
F0R78_RS14435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F0R78_RS14450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0R78_RS14450	COG4651	solute:proton antiporter activity
F0R78_RS14455	COG0439	Biotin carboxylase
F0R78_RS14460	COG5016	pyruvate
F0R78_RS14460	COG0511	ligase activity, forming carbon-carbon bonds
F0R78_RS14465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0R78_RS14470	COG1335	isochorismatase
F0R78_RS14490	COG0517	IMP dehydrogenase activity
F0R78_RS14490	COG0516	GMP reductase activity
F0R78_RS14505	COG2207	Transcriptional regulator
F0R78_RS14515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS14530	COG2873	o-acetylhomoserine
F0R78_RS14620	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0R78_RS14630	COG1388	LysM domain
F0R78_RS14630	COG0741	lytic transglycosylase activity
F0R78_RS14635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0R78_RS14640	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F0R78_RS14640	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F0R78_RS14650	COG1285	pathogenesis
F0R78_RS14670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0R78_RS14670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0R78_RS14685	COG1115	amino acid carrier protein
F0R78_RS14695	COG1509	lysine 2,3-aminomutase activity
F0R78_RS14700	COG2233	PERMEase
F0R78_RS14720	COG1393	Belongs to the ArsC family
F0R78_RS14730	COG4206	TonB-dependent receptor
F0R78_RS14730	COG1629	transport
F0R78_RS14745	COG4589	Belongs to the CDS family
F0R78_RS14755	COG2304	oxidoreductase activity
F0R78_RS14765	COG0351	phosphomethylpyrimidine kinase
F0R78_RS14775	COG1139	Iron-sulfur cluster binding protein
F0R78_RS14780	COG0247	lactate metabolic process
F0R78_RS14785	COG0602	queuosine metabolic process
F0R78_RS14795	COG2832	Protein of unknown function (DUF454)
F0R78_RS14800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0R78_RS14815	COG3142	Participates in the control of copper homeostasis
F0R78_RS14820	COG1418	mRNA catabolic process
F0R78_RS14845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F0R78_RS14865	COG4771	TonB-dependent receptor
F0R78_RS14895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0R78_RS14900	COG1061	Type III restriction enzyme res subunit
F0R78_RS14905	COG1002	Type II restriction enzyme, methylase subunits
F0R78_RS15055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F0R78_RS15055	COG0617	tRNA 3'-terminal CCA addition
F0R78_RS15055	COG0517	IMP dehydrogenase activity
F0R78_RS15080	COG0612	Peptidase, M16
F0R78_RS15090	COG1278	Cold shock
F0R78_RS15115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS15120	COG1216	Glycosyl transferase, family 2
F0R78_RS15145	COG1215	transferase activity, transferring glycosyl groups
F0R78_RS15160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS15175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F0R78_RS15185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0R78_RS15240	COG0776	regulation of translation
F0R78_RS15250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F0R78_RS15285	COG0632	four-way junction helicase activity
F0R78_RS15290	COG0673	inositol 2-dehydrogenase activity
F0R78_RS15295	COG1272	protein, Hemolysin III
F0R78_RS15300	COG1328	CTP reductase activity
F0R78_RS15310	COG2814	Major facilitator Superfamily
F0R78_RS15320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0R78_RS15330	COG0750	zinc metalloprotease
F0R78_RS15345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F0R78_RS15350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0R78_RS15360	COG1214	PFAM Peptidase M22, glycoprotease
F0R78_RS15385	COG0194	GDP metabolic process
F0R78_RS15390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0R78_RS15395	COG1408	metallophosphoesterase
F0R78_RS15400	COG1575	Belongs to the MenA family. Type 1 subfamily
F0R78_RS15405	COG1088	dTDP-glucose 4,6-dehydratase activity
F0R78_RS15410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F0R78_RS15420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F0R78_RS15430	COG2204	response regulator
F0R78_RS15435	COG0488	(ABC) transporter
F0R78_RS15505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0R78_RS15510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F0R78_RS15520	COG1522	sequence-specific DNA binding
F0R78_RS15550	COG0811	peptide transport
F0R78_RS15560	COG0084	hydrolase, TatD family'
F0R78_RS15575	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F0R78_RS15580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0R78_RS15585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F0R78_RS15590	COG0205	6-phosphofructokinase activity
F0R78_RS15610	COG0372	Belongs to the citrate synthase family
F0R78_RS15615	COG0538	isocitrate dehydrogenase activity
F0R78_RS15625	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F0R78_RS15635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F0R78_RS15660	COG0129	dihydroxy-acid dehydratase activity
F0R78_RS15685	COG2885	chlorophyll binding
F0R78_RS15705	COG3681	Belongs to the UPF0597 family
F0R78_RS15745	COG0702	epimerase
F0R78_RS15765	COG0702	epimerase
F0R78_RS15770	COG4206	TonB-dependent receptor
F0R78_RS15770	COG1629	transport
F0R78_RS15780	COG3291	Pkd domain containing protein
F0R78_RS15780	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS15790	COG4771	TonB-dependent receptor
F0R78_RS15805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0R78_RS15845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0R78_RS15845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0R78_RS15850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0R78_RS15890	COG0534	Mate efflux family protein
F0R78_RS15895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F0R78_RS15900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F0R78_RS15905	COG0166	Belongs to the GPI family
F0R78_RS15915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0R78_RS16160	COG2502	aspartate--ammonia ligase
F0R78_RS16165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0R78_RS16180	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS16190	COG1472	Belongs to the glycosyl hydrolase 3 family
F0R78_RS16205	COG0860	N-Acetylmuramoyl-L-alanine amidase
F0R78_RS16215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0R78_RS16230	COG1640	4-alpha-glucanotransferase
F0R78_RS16240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0R78_RS16245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0R78_RS16270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0R78_RS16275	COG1022	Amp-dependent synthetase and ligase
F0R78_RS16300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0R78_RS16305	COG0360	Binds together with S18 to 16S ribosomal RNA
F0R78_RS16330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0R78_RS16340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0R78_RS16360	COG4771	TonB-dependent receptor
F0R78_RS16375	COG2431	L-lysine efflux transmembrane transporter activity
F0R78_RS16400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0R78_RS16410	COG1063	alcohol dehydrogenase
F0R78_RS16450	COG0438	transferase activity, transferring glycosyl groups
F0R78_RS16555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F0R78_RS16560	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F0R78_RS16565	COG0386	Belongs to the glutathione peroxidase family
F0R78_RS16590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F0R78_RS16605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0R78_RS16615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F0R78_RS16620	COG0658	competence protein
F0R78_RS16625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F0R78_RS16630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0R78_RS16640	COG0009	L-threonylcarbamoyladenylate synthase
F0R78_RS16675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0R78_RS16680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0R78_RS16715	COG0110	maltose O-acetyltransferase activity
F0R78_RS16765	COG2089	acid synthase
F0R78_RS16770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0R78_RS16775	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
F0R78_RS16780	COG1086	Polysaccharide biosynthesis protein
F0R78_RS16815	COG2818	Glycosylase
F0R78_RS16825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F0R78_RS16825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F0R78_RS16830	COG0514	ATP-dependent DNA helicase (RecQ)
F0R78_RS16840	COG2271	Major facilitator Superfamily
F0R78_RS16855	COG0702	epimerase
F0R78_RS16860	COG4771	TonB-dependent receptor
F0R78_RS16865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0R78_RS16870	COG2186	Transcriptional regulator
F0R78_RS16885	COG0436	Aminotransferase
F0R78_RS16890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F0R78_RS16905	COG0358	DNA primase activity
F0R78_RS16910	COG3119	arylsulfatase activity
F0R78_RS16925	COG4206	TonB-dependent receptor
F0R78_RS16925	COG1629	transport
F0R78_RS16940	COG0302	gtp cyclohydrolase
F0R78_RS16950	COG0149	triose-phosphate isomerase activity
F0R78_RS16965	COG0739	heme binding
F0R78_RS16970	COG0105	UTP biosynthetic process
F0R78_RS16975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0R78_RS16980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F0R78_RS17000	COG0811	peptide transport
F0R78_RS17010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F0R78_RS17080	COG1629	transport
F0R78_RS17115	COG0039	L-malate dehydrogenase activity
F0R78_RS17150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS17165	COG4948	Mandelate Racemase Muconate Lactonizing
F0R78_RS17185	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F0R78_RS17190	COG3118	belongs to the thioredoxin family
F0R78_RS17195	COG0489	protein tyrosine kinase activity
F0R78_RS17210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0R78_RS17215	COG1722	exodeoxyribonuclease VII activity
F0R78_RS17220	COG1570	exodeoxyribonuclease VII activity
F0R78_RS17230	COG0482	sulfurtransferase activity
F0R78_RS17260	COG0179	Fumarylacetoacetate (FAA) hydrolase
F0R78_RS17265	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F0R78_RS17275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F0R78_RS17280	COG0052	Belongs to the universal ribosomal protein uS2 family
F0R78_RS17285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0R78_RS17290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0R78_RS17305	COG0017	Asparaginyl-tRNA synthetase
F0R78_RS17310	COG1187	pseudouridine synthase activity
F0R78_RS17340	COG0110	maltose O-acetyltransferase activity
F0R78_RS17350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS17410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0R78_RS17450	COG1442	glycosyl transferase family 8
F0R78_RS17450	COG1216	Glycosyl transferase, family 2
F0R78_RS17485	COG0438	transferase activity, transferring glycosyl groups
F0R78_RS17575	COG4680	protein conserved in bacteria
F0R78_RS17585	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F0R78_RS17600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0R78_RS17615	COG0517	IMP dehydrogenase activity
F0R78_RS17615	COG0516	GMP reductase activity
F0R78_RS17620	COG0514	ATP-dependent DNA helicase (RecQ)
F0R78_RS17625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0R78_RS17650	COG0724	RNA recognition motif
F0R78_RS17660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0R78_RS17665	COG1127	ABC transporter
F0R78_RS17670	COG2197	response regulator
F0R78_RS17675	COG1160	GTP binding
F0R78_RS17680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0R78_RS17685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0R78_RS17740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F0R78_RS17745	COG0470	DNA polymerase III
F0R78_RS17750	COG1774	PSP1 C-terminal conserved region
F0R78_RS17760	COG0772	Belongs to the SEDS family
F0R78_RS17775	COG1792	Involved in formation and maintenance of cell shape
F0R78_RS17785	COG0138	bifunctional purine biosynthesis protein purh
F0R78_RS17790	COG3590	peptidase
F0R78_RS17795	COG0488	(ABC) transporter
F0R78_RS17830	COG2205	protein histidine kinase activity
F0R78_RS17830	COG0784	Response regulator, receiver
F0R78_RS17835	COG0534	Mate efflux family protein
F0R78_RS17840	COG0612	Peptidase, M16
F0R78_RS17865	COG0564	pseudouridine synthase activity
F0R78_RS17910	COG2312	Erythromycin esterase
F0R78_RS17930	COG1131	(ABC) transporter
F0R78_RS18015	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F0R78_RS18030	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
F0R78_RS18050	COG1696	Membrane protein involved in D-alanine export
F0R78_RS18090	COG2986	histidine ammonia-lyase
F0R78_RS18100	COG1228	amidohydrolase
F0R78_RS18110	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F0R78_RS18140	COG0203	ribosomal protein L17
F0R78_RS18145	COG0202	RNA polymerase activity
F0R78_RS18150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0R78_RS18155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0R78_RS18160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0R78_RS18165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0R78_RS18170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F0R78_RS18185	COG0200	Binds to the 23S rRNA
F0R78_RS18190	COG1841	ribosomal large subunit assembly
F0R78_RS18195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0R78_RS18200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0R78_RS18205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F0R78_RS18210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F0R78_RS18215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0R78_RS18220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F0R78_RS18225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F0R78_RS18230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F0R78_RS18235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F0R78_RS18240	COG0255	Belongs to the universal ribosomal protein uL29 family
F0R78_RS18245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0R78_RS18250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0R78_RS18255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F0R78_RS18260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0R78_RS18265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F0R78_RS18270	COG0089	rRNA binding
F0R78_RS18275	COG0088	Forms part of the polypeptide exit tunnel
F0R78_RS18280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0R78_RS18285	COG0051	transcription antitermination factor activity, RNA binding
F0R78_RS18290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0R78_RS18295	COG0049	tRNA binding
F0R78_RS18300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F0R78_RS18335	COG0085	RNA polymerase activity
F0R78_RS18340	COG0222	ribosome binding
F0R78_RS18345	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0R78_RS18350	COG0081	regulation of translation
F0R78_RS18355	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F0R78_RS18400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0R78_RS18405	COG4974	Belongs to the 'phage' integrase family
F0R78_RS18410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F0R78_RS18420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F0R78_RS18435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0R78_RS18440	COG1480	7TM receptor with intracellular HD hydrolase
F0R78_RS18445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0R78_RS18455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F0R78_RS18475	COG1027	Aspartate ammonia-lyase
F0R78_RS18480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0R78_RS18485	COG0252	asparaginase activity
F0R78_RS18525	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F0R78_RS18535	COG4804	nuclease activity
F0R78_RS18570	COG0582	viral genome integration into host DNA
F0R78_RS18625	COG2271	Major facilitator Superfamily
F0R78_RS18635	COG4771	TonB-dependent receptor
F0R78_RS18650	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS18670	COG4771	TonB-dependent receptor
F0R78_RS18740	COG1484	DNA-dependent DNA replication
F0R78_RS18795	COG2096	Adenosyltransferase
F0R78_RS18855	COG0657	acetylesterase activity
F0R78_RS18855	COG2755	lipolytic protein G-D-S-L family
F0R78_RS18870	COG3275	phosphorelay sensor kinase activity
F0R78_RS18875	COG3279	Response regulator of the LytR AlgR family
F0R78_RS18890	COG4206	TonB-dependent receptor
F0R78_RS18910	COG2197	response regulator
F0R78_RS18930	COG2207	Transcriptional regulator
F0R78_RS18930	COG0662	Cupin 2, conserved barrel domain protein
F0R78_RS18935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0R78_RS18980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0R78_RS19025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0R78_RS19035	COG1185	polyribonucleotide nucleotidyltransferase activity
F0R78_RS19050	COG4771	TonB-dependent receptor
F0R78_RS19090	COG3426	butyrate kinase activity
F0R78_RS19095	COG0280	phosphate acetyltransferase
F0R78_RS19105	COG1619	proteins homologs of microcin C7 resistance protein MccF
F0R78_RS19110	COG2234	aminopeptidase activity
F0R78_RS19115	COG2166	iron-sulfur cluster assembly
F0R78_RS19120	COG3655	Transcriptional regulator
F0R78_RS19130	COG1266	CAAX protease self-immunity
F0R78_RS19140	COG0196	riboflavin kinase activity
F0R78_RS19145	COG1011	Hydrolase
F0R78_RS19150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0R78_RS19160	COG1773	rubredoxin
F0R78_RS19165	COG1283	sodium-dependent phosphate transmembrane transporter activity
F0R78_RS19175	COG2205	protein histidine kinase activity
F0R78_RS19205	COG0006	proline dipeptidase activity
F0R78_RS19220	COG0509	glycine decarboxylation via glycine cleavage system
F0R78_RS19225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F0R78_RS19230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F0R78_RS19250	COG0702	epimerase
F0R78_RS19255	COG4771	TonB-dependent receptor
F0R78_RS19275	COG0793	Belongs to the peptidase S41A family
F0R78_RS19280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0R78_RS19315	COG4771	TonB-dependent receptor
F0R78_RS19325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0R78_RS19330	COG1882	Formate acetyltransferase
F0R78_RS19335	COG0477	Major facilitator Superfamily
F0R78_RS19335	COG2814	Major facilitator Superfamily
F0R78_RS19355	COG1040	competence protein
F0R78_RS19360	COG0483	inositol monophosphate 1-phosphatase activity
F0R78_RS19370	COG3345	alpha-galactosidase
F0R78_RS19395	COG3475	LICD family
F0R78_RS19400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0R78_RS19410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0R78_RS19435	COG1442	glycosyl transferase family 8
F0R78_RS19560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0R78_RS19565	COG0776	regulation of translation
F0R78_RS19605	COG2207	Transcriptional regulator
F0R78_RS19605	COG1609	Transcriptional regulator
F0R78_RS19660	COG1396	sequence-specific DNA binding
F0R78_RS19680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F0R78_RS19680	COG0674	pyruvate-flavodoxin oxidoreductase activity
F0R78_RS19685	COG1013	pyruvate-flavodoxin oxidoreductase activity
F0R78_RS19700	COG0584	glycerophosphoryl diester phosphodiesterase
F0R78_RS19705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F0R78_RS19710	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F0R78_RS19715	COG1629	transport
F0R78_RS19730	COG1629	transport
F0R78_RS19745	COG5434	Belongs to the glycosyl hydrolase 28 family
F0R78_RS19770	COG1629	transport
F0R78_RS19785	COG1217	gtp-binding protein TYPA
F0R78_RS19790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F0R78_RS19800	COG0318	PFAM AMP-dependent synthetase and ligase
F0R78_RS19805	COG5002	protein histidine kinase activity
F0R78_RS19805	COG2205	protein histidine kinase activity
F0R78_RS19805	COG0784	Response regulator, receiver
F0R78_RS19830	COG3119	arylsulfatase activity
F0R78_RS19840	COG1629	transport
F0R78_RS19840	COG4206	TonB-dependent receptor
F0R78_RS19860	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0R78_RS19865	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0R78_RS19885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F0R78_RS19890	COG4974	Belongs to the 'phage' integrase family
F0R78_RS19900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0R78_RS19905	COG0606	chelatase, subunit chli
F0R78_RS19925	COG0745	RESPONSE REGULATOR receiver
F0R78_RS19925	COG2205	protein histidine kinase activity
F0R78_RS19925	COG3292	Two component regulator propeller
F0R78_RS19980	COG4974	Belongs to the 'phage' integrase family
F0R78_RS20020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0R78_RS20020	COG0551	DNA topoisomerase type I activity
F0R78_RS20040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS20060	COG0577	efflux transmembrane transporter activity
F0R78_RS20190	COG0358	DNA primase activity
F0R78_RS20210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0R78_RS20285	COG0438	transferase activity, transferring glycosyl groups
F0R78_RS20310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F0R78_RS20315	COG0438	transferase activity, transferring glycosyl groups
F0R78_RS20325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F0R78_RS20330	COG0545	Peptidyl-prolyl cis-trans isomerase
F0R78_RS20335	COG0545	Peptidyl-prolyl cis-trans isomerase
F0R78_RS20340	COG1522	sequence-specific DNA binding
F0R78_RS20360	COG3275	phosphorelay sensor kinase activity
F0R78_RS20440	COG1629	transport
F0R78_RS20440	COG4206	TonB-dependent receptor
F0R78_RS20450	COG2814	Major facilitator Superfamily
F0R78_RS20455	COG0745	RESPONSE REGULATOR receiver
F0R78_RS20455	COG3292	Two component regulator propeller
F0R78_RS20455	COG2205	protein histidine kinase activity
F0R78_RS20460	COG1621	beta-fructofuranosidase activity
F0R78_RS20505	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F0R78_RS20510	COG0793	Belongs to the peptidase S41A family
F0R78_RS20510	COG3409	Peptidoglycan-binding domain 1 protein
F0R78_RS20530	COG1053	succinate dehydrogenase
F0R78_RS20535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0R78_RS20550	COG4771	TonB-dependent receptor
F0R78_RS20580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0R78_RS20580	COG0758	DNA mediated transformation
F0R78_RS20590	COG0826	peptidase U32
F0R78_RS20600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0R78_RS20615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F0R78_RS20620	COG0557	exoribonuclease II activity
F0R78_RS20650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0R78_RS20665	COG0012	GTP binding
F0R78_RS20670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F0R78_RS20675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0R78_RS20685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F0R78_RS20695	COG0495	leucyl-tRNA aminoacylation
F0R78_RS20700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F0R78_RS20715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F0R78_RS20735	COG1215	transferase activity, transferring glycosyl groups
F0R78_RS20790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0R78_RS20790	COG0731	radical SAM domain protein
F0R78_RS20815	COG0659	secondary active sulfate transmembrane transporter activity
F0R78_RS20820	COG1592	Rubrerythrin
F0R78_RS20825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F0R78_RS20845	COG0427	acetyl-CoA hydrolase
F0R78_RS20855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0R78_RS20865	COG3250	beta-galactosidase activity
F0R78_RS20990	COG2177	Part of the ABC transporter FtsEX involved in
F0R78_RS21000	COG1968	undecaprenyl-diphosphatase activity
F0R78_RS21005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F0R78_RS21010	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F0R78_RS21015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0R78_RS21025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0R78_RS21030	COG1611	Belongs to the LOG family
F0R78_RS21045	COG0594	ribonuclease P activity
F0R78_RS21050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F0R78_RS21060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0R78_RS21065	COG1506	peptidase
F0R78_RS21065	COG4946	Tricorn protease homolog
F0R78_RS21065	COG0823	Involved in the tonB-independent uptake of proteins
F0R78_RS21075	COG3119	arylsulfatase activity
F0R78_RS21080	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
F0R78_RS21085	COG1028	Short-chain dehydrogenase reductase Sdr
F0R78_RS21095	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0R78_RS21125	COG1121	(ABC) transporter
F0R78_RS21135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F0R78_RS21135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0R78_RS21150	COG0151	Belongs to the GarS family
F0R78_RS21155	COG0823	Involved in the tonB-independent uptake of proteins
F0R78_RS21155	COG1506	peptidase
F0R78_RS21160	COG0116	Belongs to the methyltransferase superfamily
F0R78_RS21165	COG1045	serine acetyltransferase
F0R78_RS21225	COG4474	Belongs to the UPF0398 family
F0R78_RS21230	COG1475	DNA binding
F0R78_RS21250	COG2003	Belongs to the UPF0758 family
F0R78_RS21395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0R78_RS21400	COG1970	mechanosensitive ion channel activity
F0R78_RS21405	COG0776	regulation of translation
F0R78_RS21435	COG0551	DNA topoisomerase type I activity
F0R78_RS21435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0R78_RS21440	COG4804	nuclease activity
F0R78_RS21525	COG1475	DNA binding
F0R78_RS21530	COG3969	phosphoadenosine phosphosulfate
F0R78_RS21550	COG4771	TonB-dependent receptor
F0R78_RS21565	COG3279	Response regulator of the LytR AlgR family
F0R78_RS21575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0R78_RS21575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0R78_RS21595	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0R78_RS21600	COG1694	Mazg nucleotide pyrophosphohydrolase
F0R78_RS21610	COG0322	excinuclease ABC activity
F0R78_RS21615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0R78_RS21650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0R78_RS21685	COG2715	membrane protein required for spore maturation
F0R78_RS21695	COG2255	four-way junction helicase activity
F0R78_RS21710	COG3591	Belongs to the peptidase S1B family
F0R78_RS21725	COG0513	Belongs to the DEAD box helicase family
F0R78_RS21735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0R78_RS21750	COG0612	Peptidase, M16
F0R78_RS21765	COG1312	Catalyzes the dehydration of D-mannonate
F0R78_RS21770	COG1028	Short-chain dehydrogenase reductase Sdr
F0R78_RS21780	COG0681	Belongs to the peptidase S26 family
F0R78_RS21785	COG0681	Belongs to the peptidase S26 family
F0R78_RS21790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0R78_RS21820	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0R78_RS21835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS21840	COG3250	beta-galactosidase activity
F0R78_RS21870	COG0561	phosphatase activity
F0R78_RS21915	COG0745	RESPONSE REGULATOR receiver
F0R78_RS21920	COG5002	protein histidine kinase activity
F0R78_RS21925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0R78_RS21940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0R78_RS21955	COG0205	6-phosphofructokinase activity
F0R78_RS21965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0R78_RS21970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0R78_RS21975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F0R78_RS21980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0R78_RS21995	COG1442	glycosyl transferase family 8
F0R78_RS22005	COG1215	transferase activity, transferring glycosyl groups
F0R78_RS22010	COG1442	glycosyl transferase family 8
F0R78_RS22010	COG1216	Glycosyl transferase, family 2
F0R78_RS22015	COG1132	(ABC) transporter
F0R78_RS22025	COG3341	Caulimovirus viroplasmin
F0R78_RS22025	COG0328	RNA-DNA hybrid ribonuclease activity
F0R78_RS22050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0R78_RS22060	COG0326	Molecular chaperone. Has ATPase activity
F0R78_RS22070	COG1166	arginine decarboxylase activity
F0R78_RS22075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0R78_RS22145	COG1454	alcohol dehydrogenase
F0R78_RS22150	COG0235	Class ii aldolase
F0R78_RS22155	COG1070	Carbohydrate kinase
F0R78_RS22160	COG0738	Major facilitator superfamily
F0R78_RS22165	COG0779	Required for maturation of 30S ribosomal subunits
F0R78_RS22170	COG0195	Participates in both transcription termination and antitermination
F0R78_RS22175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0R78_RS22185	COG0719	Fe-S assembly protein
F0R78_RS22195	COG0396	ATPase activity
F0R78_RS22200	COG0719	Fe-S assembly protein
F0R78_RS22205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0R78_RS22210	COG0393	Putative heavy-metal-binding
F0R78_RS22215	COG3345	alpha-galactosidase
F0R78_RS22225	COG1629	transport
F0R78_RS22250	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F0R78_RS22260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0R78_RS22275	COG2205	protein histidine kinase activity
F0R78_RS22275	COG2202	Pas domain
F0R78_RS22295	COG0187	DNA topoisomerase II activity
F0R78_RS22300	COG0268	Binds directly to 16S ribosomal RNA
F0R78_RS22315	COG1381	Involved in DNA repair and RecF pathway recombination
F0R78_RS22320	COG1610	YqeY-like protein
F0R78_RS22325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F0R78_RS22340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0R78_RS22345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F0R78_RS22350	COG0772	Belongs to the SEDS family
F0R78_RS22355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F0R78_RS22360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0R78_RS22365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0R78_RS22385	COG2001	Belongs to the MraZ family
F0R78_RS22405	COG4771	TonB-dependent receptor
F0R78_RS22435	COG0756	dUTP diphosphatase activity
F0R78_RS22450	COG4942	peptidase
F0R78_RS22455	COG3292	Two component regulator propeller
F0R78_RS22455	COG0745	RESPONSE REGULATOR receiver
F0R78_RS22455	COG2205	protein histidine kinase activity
F0R78_RS22460	COG3940	Belongs to the glycosyl hydrolase 43 family
F0R78_RS22475	COG3250	beta-galactosidase activity
F0R78_RS22490	COG3940	Belongs to the glycosyl hydrolase 43 family
F0R78_RS22510	COG0383	alpha-mannosidase activity
F0R78_RS22515	COG1629	transport
F0R78_RS22515	COG4206	TonB-dependent receptor
F0R78_RS22535	COG3507	Belongs to the glycosyl hydrolase 43 family
F0R78_RS22570	COG3537	Alpha-1,2-mannosidase
F0R78_RS22580	COG2017	converts alpha-aldose to the beta-anomer
F0R78_RS22675	COG3408	Glycogen debranching enzyme
F0R78_RS22680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0R78_RS22685	COG1022	Amp-dependent synthetase and ligase
F0R78_RS22700	COG2954	triphosphatase activity
F0R78_RS22720	COG3250	beta-galactosidase activity
F0R78_RS22725	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0R78_RS22735	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F0R78_RS22755	COG1629	transport
F0R78_RS22755	COG4206	TonB-dependent receptor
F0R78_RS22760	COG0745	RESPONSE REGULATOR receiver
F0R78_RS22760	COG2205	protein histidine kinase activity
F0R78_RS22760	COG3292	Two component regulator propeller
F0R78_RS22765	COG3292	Two component regulator propeller
F0R78_RS22765	COG0745	RESPONSE REGULATOR receiver
F0R78_RS22765	COG2205	protein histidine kinase activity
F0R78_RS22790	COG4771	TonB-dependent receptor
F0R78_RS22860	COG4771	TonB-dependent receptor
F0R78_RS22885	COG0423	glycine-tRNA ligase activity
F0R78_RS22890	COG0545	Peptidyl-prolyl cis-trans isomerase
F0R78_RS22920	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F0R78_RS22950	COG4771	TonB-dependent receptor
F0R78_RS22955	COG3292	Two component regulator propeller
F0R78_RS22955	COG3292	Two component regulator propeller
F0R78_RS22955	COG0745	RESPONSE REGULATOR receiver
F0R78_RS22955	COG2205	protein histidine kinase activity
F0R78_RS22955	COG0745	RESPONSE REGULATOR receiver
F0R78_RS22955	COG2205	protein histidine kinase activity
F0R78_RS22965	COG3005	denitrification pathway
F0R78_RS22970	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F0R78_RS22980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0R78_RS23000	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0R78_RS23020	COG3876	Protein conserved in bacteria
F0R78_RS23040	COG1216	Glycosyl transferase, family 2
F0R78_RS23040	COG0463	Glycosyl transferase, family 2
F0R78_RS23055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0R78_RS23060	COG3876	Protein conserved in bacteria
F0R78_RS23065	COG0702	epimerase
F0R78_RS23070	COG4206	TonB-dependent receptor
F0R78_RS23070	COG1629	transport
F0R78_RS23090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0R78_RS23095	COG0589	response to stress
F0R78_RS23095	COG0475	glutathione-regulated potassium exporter activity
F0R78_RS23100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F0R78_RS23105	COG1136	(ABC) transporter
F0R78_RS23115	COG0733	neurotransmitter:sodium symporter activity
F0R78_RS23125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F0R78_RS23140	COG0076	glutamate decarboxylase activity
F0R78_RS23145	COG2066	Belongs to the glutaminase family
F0R78_RS23150	COG5002	protein histidine kinase activity
F0R78_RS23150	COG0784	Response regulator, receiver
F0R78_RS23150	COG2198	Histidine kinase
F0R78_RS23155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F0R78_RS23160	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F0R78_RS23265	COG1346	cytolysis
F0R78_RS23290	COG0280	phosphate acetyltransferase
F0R78_RS23295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0R78_RS23300	COG1785	Belongs to the alkaline phosphatase family
F0R78_RS23305	COG2151	metal-sulfur cluster biosynthetic enzyme
F0R78_RS23310	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0R78_RS23315	COG2003	Belongs to the UPF0758 family
F0R78_RS23320	COG1216	Glycosyl transferase, family 2
F0R78_RS23320	COG0463	Glycosyl transferase, family 2
F0R78_RS23335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F0R78_RS23340	COG2815	serine threonine protein kinase
F0R78_RS23340	COG0515	serine threonine protein kinase
F0R78_RS23345	COG0564	pseudouridine synthase activity
F0R78_RS23390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F0R78_RS23395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F0R78_RS23405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F0R78_RS23425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0R78_RS23435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0R78_RS23435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0R78_RS23440	COG2890	protein-(glutamine-N5) methyltransferase activity
F0R78_RS23445	COG2137	regulation of response to DNA damage stimulus
F0R78_RS23450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0R78_RS23485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0R78_RS23490	COG1917	Cupin 2, conserved barrel domain protein
F0R78_RS23490	COG1396	sequence-specific DNA binding
F0R78_RS23495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F0R78_RS23500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0R78_RS23510	COG0137	argininosuccinate synthase activity
F0R78_RS23535	COG2205	protein histidine kinase activity
F0R78_RS23535	COG3437	response regulator, receiver
F0R78_RS23535	COG3850	Histidine kinase
F0R78_RS23535	COG4999	Histidine kinase
F0R78_RS23540	COG0531	amino acid
F0R78_RS23550	COG0039	L-malate dehydrogenase activity
F0R78_RS23555	COG2996	Protein conserved in bacteria
F0R78_RS23575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0R78_RS23580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F0R78_RS23605	COG1629	transport
F0R78_RS23635	COG1136	(ABC) transporter
F0R78_RS23635	COG0577	efflux transmembrane transporter activity
F0R78_RS23640	COG0577	efflux transmembrane transporter activity
F0R78_RS23640	COG1136	(ABC) transporter
F0R78_RS23645	COG1136	(ABC) transporter
F0R78_RS23650	COG1940	carbohydrate kinase activity
F0R78_RS23655	COG0335	large ribosomal subunit rRNA binding
F0R78_RS23660	COG0737	Belongs to the 5'-nucleotidase family
F0R78_RS23665	COG0737	Belongs to the 5'-nucleotidase family
F0R78_RS23670	COG1472	Belongs to the glycosyl hydrolase 3 family
F0R78_RS23675	COG1472	Belongs to the glycosyl hydrolase 3 family
F0R78_RS23680	COG4206	TonB-dependent receptor
F0R78_RS23680	COG1629	transport
F0R78_RS23690	COG3119	arylsulfatase activity
F0R78_RS23715	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0R78_RS23725	COG2204	response regulator
F0R78_RS23735	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F0R78_RS23755	COG2205	protein histidine kinase activity
F0R78_RS23760	COG5002	protein histidine kinase activity
F0R78_RS23775	COG4771	TonB-dependent receptor
F0R78_RS23820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0R78_RS23820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0R78_RS23825	COG0436	Aminotransferase
F0R78_RS23830	COG3250	beta-galactosidase activity
F0R78_RS23845	COG0826	peptidase U32
F0R78_RS23855	COG4771	TonB-dependent receptor
F0R78_RS23860	COG2197	response regulator
F0R78_RS23865	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
F0R78_RS23875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F0R78_RS23885	COG0252	asparaginase activity
F0R78_RS23890	COG0460	homoserine dehydrogenase
F0R78_RS23890	COG0527	aspartate kinase activity
F0R78_RS23895	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
F0R78_RS23900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F0R78_RS23960	COG1629	transport
F0R78_RS23960	COG4206	TonB-dependent receptor
F0R78_RS23965	COG0702	epimerase
F0R78_RS23970	COG3250	beta-galactosidase activity
F0R78_RS23995	COG4771	TonB-dependent receptor
F0R78_RS24020	COG0628	permease
F0R78_RS24035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F0R78_RS24050	COG2095	MarC family integral membrane protein
F0R78_RS24060	COG4206	TonB-dependent receptor
F0R78_RS24060	COG1629	transport
F0R78_RS24070	COG4974	Belongs to the 'phage' integrase family
F0R78_RS24075	COG4206	TonB-dependent receptor
F0R78_RS24075	COG1629	transport
F0R78_RS24085	COG1629	transport
F0R78_RS24095	COG4771	TonB-dependent receptor
F0R78_RS24100	COG0702	epimerase
F0R78_RS24105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0R78_RS24125	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F0R78_RS24125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F0R78_RS24140	COG0531	amino acid
F0R78_RS24155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0R78_RS24160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS24165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0R78_RS24205	COG1162	GTPase activity
F0R78_RS24210	COG0233	cytoplasmic translational termination