locus-tag	class	description
K0E66_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K0E66_RS00020	COG1640	4-alpha-glucanotransferase
K0E66_RS00030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K0E66_RS00035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K0E66_RS00060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K0E66_RS00065	COG1022	Amp-dependent synthetase and ligase
K0E66_RS00075	COG0359	binds to the 23S rRNA
K0E66_RS00080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K0E66_RS00085	COG0360	Binds together with S18 to 16S ribosomal RNA
K0E66_RS00110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K0E66_RS00135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K0E66_RS00155	COG4771	TonB-dependent receptor
K0E66_RS00170	COG2431	L-lysine efflux transmembrane transporter activity
K0E66_RS00210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K0E66_RS00215	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K0E66_RS00220	COG0386	Belongs to the glutathione peroxidase family
K0E66_RS00240	COG3275	phosphorelay sensor kinase activity
K0E66_RS00245	COG3279	Response regulator of the LytR AlgR family
K0E66_RS00255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K0E66_RS00265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K0E66_RS00280	COG3250	beta-galactosidase activity
K0E66_RS00285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K0E66_RS00295	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K0E66_RS00300	COG0658	competence protein
K0E66_RS00305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K0E66_RS00310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K0E66_RS00320	COG0009	L-threonylcarbamoyladenylate synthase
K0E66_RS00350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K0E66_RS00355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS00370	COG0438	transferase activity, transferring glycosyl groups
K0E66_RS00420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS00430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K0E66_RS00435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K0E66_RS00485	COG0519	Catalyzes the synthesis of GMP from XMP
K0E66_RS00495	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K0E66_RS00495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K0E66_RS00500	COG0514	ATP-dependent DNA helicase (RecQ)
K0E66_RS00525	COG0436	Aminotransferase
K0E66_RS00530	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K0E66_RS00540	COG0358	DNA primase activity
K0E66_RS00545	COG3119	arylsulfatase activity
K0E66_RS00550	COG0702	epimerase
K0E66_RS00555	COG1629	transport
K0E66_RS00555	COG4206	TonB-dependent receptor
K0E66_RS00570	COG0302	gtp cyclohydrolase
K0E66_RS00580	COG0149	triose-phosphate isomerase activity
K0E66_RS00595	COG0739	heme binding
K0E66_RS00600	COG0105	UTP biosynthetic process
K0E66_RS00605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K0E66_RS00630	COG0811	peptide transport
K0E66_RS00640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K0E66_RS00680	COG1629	transport
K0E66_RS00710	COG4946	Tricorn protease homolog
K0E66_RS00710	COG0823	Involved in the tonB-independent uptake of proteins
K0E66_RS00710	COG1506	peptidase
K0E66_RS00715	COG0039	L-malate dehydrogenase activity
K0E66_RS00755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K0E66_RS00770	COG4948	Mandelate Racemase Muconate Lactonizing
K0E66_RS00795	COG3118	belongs to the thioredoxin family
K0E66_RS00800	COG0489	protein tyrosine kinase activity
K0E66_RS00815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K0E66_RS00825	COG1570	exodeoxyribonuclease VII activity
K0E66_RS00835	COG0482	sulfurtransferase activity
K0E66_RS00850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K0E66_RS00855	COG0179	Fumarylacetoacetate (FAA) hydrolase
K0E66_RS00860	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K0E66_RS00870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K0E66_RS00875	COG0052	Belongs to the universal ribosomal protein uS2 family
K0E66_RS00880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K0E66_RS00885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K0E66_RS00900	COG0017	Asparaginyl-tRNA synthetase
K0E66_RS00905	COG1187	pseudouridine synthase activity
K0E66_RS00935	COG0110	maltose O-acetyltransferase activity
K0E66_RS00940	COG3022	response to hydroperoxide
K0E66_RS00945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS01000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K0E66_RS01040	COG1216	Glycosyl transferase, family 2
K0E66_RS01065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K0E66_RS01100	COG0297	glycogen (starch) synthase activity
K0E66_RS01125	COG0745	RESPONSE REGULATOR receiver
K0E66_RS01190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K0E66_RS01205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K0E66_RS01220	COG0516	GMP reductase activity
K0E66_RS01220	COG0517	IMP dehydrogenase activity
K0E66_RS01225	COG0514	ATP-dependent DNA helicase (RecQ)
K0E66_RS01230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K0E66_RS01240	COG0544	peptidyl-prolyl cis-trans isomerase activity
K0E66_RS01245	COG0724	RNA recognition motif
K0E66_RS01255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K0E66_RS01260	COG1127	ABC transporter
K0E66_RS01265	COG0745	RESPONSE REGULATOR receiver
K0E66_RS01270	COG1160	GTP binding
K0E66_RS01275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K0E66_RS01280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K0E66_RS01320	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K0E66_RS01325	COG0470	DNA polymerase III
K0E66_RS01330	COG1774	PSP1 C-terminal conserved region
K0E66_RS01340	COG0772	Belongs to the SEDS family
K0E66_RS01355	COG1792	Involved in formation and maintenance of cell shape
K0E66_RS01365	COG0138	bifunctional purine biosynthesis protein purh
K0E66_RS01370	COG3590	peptidase
K0E66_RS01375	COG0488	(ABC) transporter
K0E66_RS01400	COG0784	Response regulator, receiver
K0E66_RS01400	COG2205	protein histidine kinase activity
K0E66_RS01405	COG0534	Mate efflux family protein
K0E66_RS01410	COG0612	Peptidase, M16
K0E66_RS01415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K0E66_RS01430	COG0564	pseudouridine synthase activity
K0E66_RS01470	COG1131	(ABC) transporter
K0E66_RS01590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K0E66_RS01595	COG1120	ATPase activity
K0E66_RS01620	COG1192	Involved in chromosome partitioning
K0E66_RS01630	COG1629	transport
K0E66_RS01695	COG4974	Belongs to the 'phage' integrase family
K0E66_RS01720	COG1696	Membrane protein involved in D-alanine export
K0E66_RS01755	COG1309	transcriptional regulator
K0E66_RS01760	COG2986	histidine ammonia-lyase
K0E66_RS01770	COG1228	amidohydrolase
K0E66_RS01780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K0E66_RS01795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K0E66_RS01810	COG0203	ribosomal protein L17
K0E66_RS01815	COG0202	RNA polymerase activity
K0E66_RS01820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K0E66_RS01825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K0E66_RS01830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K0E66_RS01835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K0E66_RS01840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K0E66_RS01855	COG0200	Binds to the 23S rRNA
K0E66_RS01860	COG1841	ribosomal large subunit assembly
K0E66_RS01865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K0E66_RS01870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K0E66_RS01875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K0E66_RS01880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K0E66_RS01885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K0E66_RS01890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K0E66_RS01895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K0E66_RS01900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K0E66_RS01905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K0E66_RS01910	COG0255	Belongs to the universal ribosomal protein uL29 family
K0E66_RS01915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K0E66_RS01920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K0E66_RS01925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K0E66_RS01930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K0E66_RS01935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K0E66_RS01940	COG0089	rRNA binding
K0E66_RS01945	COG0088	Forms part of the polypeptide exit tunnel
K0E66_RS01950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K0E66_RS01955	COG0051	transcription antitermination factor activity, RNA binding
K0E66_RS01960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K0E66_RS01965	COG0049	tRNA binding
K0E66_RS01970	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K0E66_RS02000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K0E66_RS02005	COG0085	RNA polymerase activity
K0E66_RS02010	COG0222	ribosome binding
K0E66_RS02015	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K0E66_RS02020	COG0081	regulation of translation
K0E66_RS02025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K0E66_RS02070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K0E66_RS02075	COG4974	Belongs to the 'phage' integrase family
K0E66_RS02080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K0E66_RS02085	COG0006	proline dipeptidase activity
K0E66_RS02090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K0E66_RS02100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K0E66_RS02105	COG1480	7TM receptor with intracellular HD hydrolase
K0E66_RS02110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K0E66_RS02120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K0E66_RS02140	COG1027	Aspartate ammonia-lyase
K0E66_RS02145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K0E66_RS02150	COG0252	asparaginase activity
K0E66_RS02165	COG2096	Adenosyltransferase
K0E66_RS02200	COG0657	acetylesterase activity
K0E66_RS02200	COG2755	lipolytic protein G-D-S-L family
K0E66_RS02215	COG3279	Response regulator of the LytR AlgR family
K0E66_RS02230	COG4771	TonB-dependent receptor
K0E66_RS02270	COG0702	epimerase
K0E66_RS02275	COG1629	transport
K0E66_RS02280	COG4977	sequence-specific DNA binding
K0E66_RS02280	COG1917	Cupin 2, conserved barrel domain protein
K0E66_RS02295	COG2197	response regulator
K0E66_RS02300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K0E66_RS02305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K0E66_RS02330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K0E66_RS02340	COG1185	polyribonucleotide nucleotidyltransferase activity
K0E66_RS02355	COG4771	TonB-dependent receptor
K0E66_RS02375	COG3426	butyrate kinase activity
K0E66_RS02380	COG0280	phosphate acetyltransferase
K0E66_RS02390	COG1619	proteins homologs of microcin C7 resistance protein MccF
K0E66_RS02395	COG2234	aminopeptidase activity
K0E66_RS02400	COG2166	iron-sulfur cluster assembly
K0E66_RS02405	COG3655	Transcriptional regulator
K0E66_RS02415	COG1266	CAAX protease self-immunity
K0E66_RS02420	COG0196	riboflavin kinase activity
K0E66_RS02425	COG1011	Hydrolase
K0E66_RS02430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K0E66_RS02435	COG0784	Response regulator, receiver
K0E66_RS02435	COG2205	protein histidine kinase activity
K0E66_RS02440	COG1773	rubredoxin
K0E66_RS02445	COG1283	sodium-dependent phosphate transmembrane transporter activity
K0E66_RS02455	COG2205	protein histidine kinase activity
K0E66_RS02480	COG0006	proline dipeptidase activity
K0E66_RS02495	COG0509	glycine decarboxylation via glycine cleavage system
K0E66_RS02500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K0E66_RS02525	COG0702	epimerase
K0E66_RS02530	COG4771	TonB-dependent receptor
K0E66_RS02545	COG0793	Belongs to the peptidase S41A family
K0E66_RS02550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K0E66_RS02590	COG4771	TonB-dependent receptor
K0E66_RS02595	COG3292	Two component regulator propeller
K0E66_RS02595	COG0745	RESPONSE REGULATOR receiver
K0E66_RS02595	COG2205	protein histidine kinase activity
K0E66_RS02600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K0E66_RS02610	COG0477	Major facilitator Superfamily
K0E66_RS02610	COG2814	Major facilitator Superfamily
K0E66_RS02635	COG0483	inositol monophosphate 1-phosphatase activity
K0E66_RS02645	COG3345	alpha-galactosidase
K0E66_RS02670	COG3475	LICD family
K0E66_RS02675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K0E66_RS02705	COG0438	transferase activity, transferring glycosyl groups
K0E66_RS02715	COG1442	glycosyl transferase family 8
K0E66_RS02750	COG0776	regulation of translation
K0E66_RS02755	COG1970	mechanosensitive ion channel activity
K0E66_RS02775	COG4771	TonB-dependent receptor
K0E66_RS02800	COG3292	Two component regulator propeller
K0E66_RS02800	COG2205	protein histidine kinase activity
K0E66_RS02800	COG0745	RESPONSE REGULATOR receiver
K0E66_RS02825	COG2816	NAD+ diphosphatase activity
K0E66_RS02875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K0E66_RS02880	COG0776	regulation of translation
K0E66_RS02915	COG1609	Transcriptional regulator
K0E66_RS02915	COG2207	Transcriptional regulator
K0E66_RS02930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K0E66_RS02930	COG0674	pyruvate-flavodoxin oxidoreductase activity
K0E66_RS02935	COG1013	pyruvate-flavodoxin oxidoreductase activity
K0E66_RS02940	COG0584	glycerophosphoryl diester phosphodiesterase
K0E66_RS02945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K0E66_RS02950	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K0E66_RS02955	COG1629	transport
K0E66_RS02955	COG4206	TonB-dependent receptor
K0E66_RS02970	COG1629	transport
K0E66_RS03005	COG1629	transport
K0E66_RS03015	COG1217	gtp-binding protein TYPA
K0E66_RS03020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K0E66_RS03030	COG0318	PFAM AMP-dependent synthetase and ligase
K0E66_RS03050	COG3119	arylsulfatase activity
K0E66_RS03060	COG1629	transport
K0E66_RS03060	COG4206	TonB-dependent receptor
K0E66_RS03075	COG4591	ABC-type transport system involved in lipoprotein release permease component
K0E66_RS03080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K0E66_RS03095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K0E66_RS03100	COG4974	Belongs to the 'phage' integrase family
K0E66_RS03115	COG0606	chelatase, subunit chli
K0E66_RS03205	COG0438	transferase activity, transferring glycosyl groups
K0E66_RS03230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K0E66_RS03235	COG0438	transferase activity, transferring glycosyl groups
K0E66_RS03245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K0E66_RS03250	COG0545	Peptidyl-prolyl cis-trans isomerase
K0E66_RS03255	COG0545	Peptidyl-prolyl cis-trans isomerase
K0E66_RS03260	COG1522	sequence-specific DNA binding
K0E66_RS03280	COG3275	phosphorelay sensor kinase activity
K0E66_RS03295	COG1566	PFAM secretion protein HlyD family protein
K0E66_RS03350	COG4206	TonB-dependent receptor
K0E66_RS03350	COG1629	transport
K0E66_RS03360	COG2814	Major facilitator Superfamily
K0E66_RS03380	COG2205	protein histidine kinase activity
K0E66_RS03380	COG0745	RESPONSE REGULATOR receiver
K0E66_RS03380	COG3292	Two component regulator propeller
K0E66_RS03385	COG1621	beta-fructofuranosidase activity
K0E66_RS03435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K0E66_RS03440	COG0793	Belongs to the peptidase S41A family
K0E66_RS03440	COG3409	Peptidoglycan-binding domain 1 protein
K0E66_RS03465	COG1053	succinate dehydrogenase
K0E66_RS03470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K0E66_RS03485	COG4771	TonB-dependent receptor
K0E66_RS03510	COG0758	DNA mediated transformation
K0E66_RS03510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K0E66_RS03520	COG0826	peptidase U32
K0E66_RS03530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K0E66_RS03545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K0E66_RS03550	COG0557	exoribonuclease II activity
K0E66_RS03570	COG1595	DNA-templated transcription, initiation
K0E66_RS03590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K0E66_RS03605	COG0012	GTP binding
K0E66_RS03610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K0E66_RS03615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K0E66_RS03625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K0E66_RS03630	COG0495	leucyl-tRNA aminoacylation
K0E66_RS03635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K0E66_RS03655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K0E66_RS03680	COG0731	radical SAM domain protein
K0E66_RS03680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K0E66_RS03705	COG0659	secondary active sulfate transmembrane transporter activity
K0E66_RS03710	COG1592	Rubrerythrin
K0E66_RS03715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K0E66_RS03735	COG0427	acetyl-CoA hydrolase
K0E66_RS03745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K0E66_RS03755	COG3250	beta-galactosidase activity
K0E66_RS03840	COG2177	Part of the ABC transporter FtsEX involved in
K0E66_RS03850	COG1968	undecaprenyl-diphosphatase activity
K0E66_RS03855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K0E66_RS03860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K0E66_RS03865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K0E66_RS03875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K0E66_RS03880	COG1611	Belongs to the LOG family
K0E66_RS03895	COG0594	ribonuclease P activity
K0E66_RS03900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K0E66_RS03915	COG4946	Tricorn protease homolog
K0E66_RS03915	COG1506	peptidase
K0E66_RS03915	COG0823	Involved in the tonB-independent uptake of proteins
K0E66_RS03925	COG3119	arylsulfatase activity
K0E66_RS03930	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K0E66_RS03935	COG1028	Short-chain dehydrogenase reductase Sdr
K0E66_RS03940	COG4677	pectinesterase activity
K0E66_RS03945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K0E66_RS03975	COG1121	(ABC) transporter
K0E66_RS03985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K0E66_RS03985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K0E66_RS04005	COG1506	peptidase
K0E66_RS04005	COG0823	Involved in the tonB-independent uptake of proteins
K0E66_RS04010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K0E66_RS04010	COG0116	Belongs to the methyltransferase superfamily
K0E66_RS04015	COG1045	serine acetyltransferase
K0E66_RS04020	COG3275	phosphorelay sensor kinase activity
K0E66_RS04025	COG3279	Response regulator of the LytR AlgR family
K0E66_RS04035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K0E66_RS04035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K0E66_RS04050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K0E66_RS04055	COG1694	Mazg nucleotide pyrophosphohydrolase
K0E66_RS04065	COG0322	excinuclease ABC activity
K0E66_RS04070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K0E66_RS04120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K0E66_RS04125	COG2715	membrane protein required for spore maturation
K0E66_RS04140	COG2255	four-way junction helicase activity
K0E66_RS04155	COG3591	Belongs to the peptidase S1B family
K0E66_RS04165	COG0513	Belongs to the DEAD box helicase family
K0E66_RS04175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K0E66_RS04190	COG0612	Peptidase, M16
K0E66_RS04210	COG1312	Catalyzes the dehydration of D-mannonate
K0E66_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
K0E66_RS04225	COG0681	Belongs to the peptidase S26 family
K0E66_RS04235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K0E66_RS04265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K0E66_RS04280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K0E66_RS04285	COG3250	beta-galactosidase activity
K0E66_RS04305	COG0215	cysteine-tRNA ligase activity
K0E66_RS04310	COG0561	phosphatase activity
K0E66_RS04370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K0E66_RS04385	COG0205	6-phosphofructokinase activity
K0E66_RS04395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K0E66_RS04400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K0E66_RS04405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K0E66_RS04410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K0E66_RS04420	COG1216	Glycosyl transferase, family 2
K0E66_RS04440	COG1442	glycosyl transferase family 8
K0E66_RS04445	COG1216	Glycosyl transferase, family 2
K0E66_RS04445	COG1442	glycosyl transferase family 8
K0E66_RS04455	COG1442	glycosyl transferase family 8
K0E66_RS04455	COG1216	Glycosyl transferase, family 2
K0E66_RS04460	COG1132	(ABC) transporter
K0E66_RS04465	COG0328	RNA-DNA hybrid ribonuclease activity
K0E66_RS04465	COG3341	Caulimovirus viroplasmin
K0E66_RS04475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K0E66_RS04485	COG0326	Molecular chaperone. Has ATPase activity
K0E66_RS04495	COG1166	arginine decarboxylase activity
K0E66_RS04500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K0E66_RS04505	COG1595	DNA-templated transcription, initiation
K0E66_RS04550	COG1454	alcohol dehydrogenase
K0E66_RS04555	COG0235	Class ii aldolase
K0E66_RS04560	COG1070	Carbohydrate kinase
K0E66_RS04565	COG0738	Major facilitator superfamily
K0E66_RS04585	COG0779	Required for maturation of 30S ribosomal subunits
K0E66_RS04590	COG0195	Participates in both transcription termination and antitermination
K0E66_RS04595	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K0E66_RS04605	COG0719	Fe-S assembly protein
K0E66_RS04615	COG0396	ATPase activity
K0E66_RS04620	COG0719	Fe-S assembly protein
K0E66_RS04625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K0E66_RS04630	COG0393	Putative heavy-metal-binding
K0E66_RS04635	COG3345	alpha-galactosidase
K0E66_RS04645	COG4771	TonB-dependent receptor
K0E66_RS04670	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K0E66_RS04675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K0E66_RS04700	COG0187	DNA topoisomerase II activity
K0E66_RS04705	COG0268	Binds directly to 16S ribosomal RNA
K0E66_RS04715	COG1381	Involved in DNA repair and RecF pathway recombination
K0E66_RS04720	COG1610	YqeY-like protein
K0E66_RS04725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K0E66_RS04740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K0E66_RS04745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K0E66_RS04750	COG0772	Belongs to the SEDS family
K0E66_RS04755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K0E66_RS04760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K0E66_RS04765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K0E66_RS04780	COG0275	rRNA processing
K0E66_RS04785	COG2001	Belongs to the MraZ family
K0E66_RS04800	COG4771	TonB-dependent receptor
K0E66_RS04825	COG0756	dUTP diphosphatase activity
K0E66_RS04840	COG4942	peptidase
K0E66_RS04845	COG0745	RESPONSE REGULATOR receiver
K0E66_RS04845	COG3292	Two component regulator propeller
K0E66_RS04845	COG2205	protein histidine kinase activity
K0E66_RS04850	COG3940	Belongs to the glycosyl hydrolase 43 family
K0E66_RS04860	COG3250	beta-galactosidase activity
K0E66_RS04890	COG0383	alpha-mannosidase activity
K0E66_RS04895	COG1629	transport
K0E66_RS04895	COG4206	TonB-dependent receptor
K0E66_RS04915	COG3507	Belongs to the glycosyl hydrolase 43 family
K0E66_RS04935	COG3537	Alpha-1,2-mannosidase
K0E66_RS04945	COG2017	converts alpha-aldose to the beta-anomer
K0E66_RS05000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K0E66_RS05005	COG1022	Amp-dependent synthetase and ligase
K0E66_RS05020	COG2954	triphosphatase activity
K0E66_RS05040	COG3250	beta-galactosidase activity
K0E66_RS05045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS05050	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K0E66_RS05055	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K0E66_RS05070	COG4206	TonB-dependent receptor
K0E66_RS05070	COG1629	transport
K0E66_RS05075	COG2205	protein histidine kinase activity
K0E66_RS05075	COG0745	RESPONSE REGULATOR receiver
K0E66_RS05075	COG3292	Two component regulator propeller
K0E66_RS05080	COG2205	protein histidine kinase activity
K0E66_RS05080	COG3292	Two component regulator propeller
K0E66_RS05080	COG0745	RESPONSE REGULATOR receiver
K0E66_RS05105	COG4771	TonB-dependent receptor
K0E66_RS05155	COG0673	inositol 2-dehydrogenase activity
K0E66_RS05165	COG4771	TonB-dependent receptor
K0E66_RS05190	COG0423	glycine-tRNA ligase activity
K0E66_RS05195	COG0545	Peptidyl-prolyl cis-trans isomerase
K0E66_RS05205	COG3005	denitrification pathway
K0E66_RS05210	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K0E66_RS05220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K0E66_RS05240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K0E66_RS05260	COG3876	Protein conserved in bacteria
K0E66_RS05280	COG1216	Glycosyl transferase, family 2
K0E66_RS05280	COG0463	Glycosyl transferase, family 2
K0E66_RS05295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K0E66_RS05300	COG3876	Protein conserved in bacteria
K0E66_RS05310	COG4206	TonB-dependent receptor
K0E66_RS05310	COG1629	transport
K0E66_RS05330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K0E66_RS05335	COG0475	glutathione-regulated potassium exporter activity
K0E66_RS05335	COG0589	response to stress
K0E66_RS05340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K0E66_RS05355	COG0733	neurotransmitter:sodium symporter activity
K0E66_RS05365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K0E66_RS05375	COG0076	glutamate decarboxylase activity
K0E66_RS05380	COG2066	Belongs to the glutaminase family
K0E66_RS05390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K0E66_RS05395	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K0E66_RS05505	COG1346	cytolysis
K0E66_RS05530	COG0280	phosphate acetyltransferase
K0E66_RS05535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K0E66_RS05540	COG1785	Belongs to the alkaline phosphatase family
K0E66_RS05550	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K0E66_RS05555	COG2003	Belongs to the UPF0758 family
K0E66_RS05560	COG0463	Glycosyl transferase, family 2
K0E66_RS05560	COG1216	Glycosyl transferase, family 2
K0E66_RS05565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K0E66_RS05570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K0E66_RS05575	COG2815	serine threonine protein kinase
K0E66_RS05575	COG0515	serine threonine protein kinase
K0E66_RS05580	COG0564	pseudouridine synthase activity
K0E66_RS05640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K0E66_RS05645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K0E66_RS05655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K0E66_RS05675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K0E66_RS05685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K0E66_RS05685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K0E66_RS05690	COG2890	protein-(glutamine-N5) methyltransferase activity
K0E66_RS05695	COG2137	regulation of response to DNA damage stimulus
K0E66_RS05700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K0E66_RS05725	COG1929	Belongs to the glycerate kinase type-1 family
K0E66_RS05735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K0E66_RS05740	COG1396	sequence-specific DNA binding
K0E66_RS05740	COG1917	Cupin 2, conserved barrel domain protein
K0E66_RS05745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K0E66_RS05750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K0E66_RS05755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K0E66_RS05760	COG0137	argininosuccinate synthase activity
K0E66_RS05785	COG0531	amino acid
K0E66_RS05795	COG0039	L-malate dehydrogenase activity
K0E66_RS05800	COG2996	Protein conserved in bacteria
K0E66_RS05825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K0E66_RS05830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K0E66_RS05850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K0E66_RS05855	COG0577	efflux transmembrane transporter activity
K0E66_RS05855	COG1136	(ABC) transporter
K0E66_RS05860	COG0577	efflux transmembrane transporter activity
K0E66_RS05860	COG1136	(ABC) transporter
K0E66_RS05865	COG1136	(ABC) transporter
K0E66_RS05870	COG1940	carbohydrate kinase activity
K0E66_RS05875	COG0335	large ribosomal subunit rRNA binding
K0E66_RS05880	COG0737	Belongs to the 5'-nucleotidase family
K0E66_RS05885	COG0737	Belongs to the 5'-nucleotidase family
K0E66_RS05890	COG1472	Belongs to the glycosyl hydrolase 3 family
K0E66_RS05895	COG1472	Belongs to the glycosyl hydrolase 3 family
K0E66_RS05900	COG4206	TonB-dependent receptor
K0E66_RS05900	COG1629	transport
K0E66_RS05910	COG3119	arylsulfatase activity
K0E66_RS05935	COG0446	pyridine nucleotide-disulphide oxidoreductase
K0E66_RS05945	COG2204	response regulator
K0E66_RS05950	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K0E66_RS05970	COG2205	protein histidine kinase activity
K0E66_RS05975	COG5002	protein histidine kinase activity
K0E66_RS05990	COG4771	TonB-dependent receptor
K0E66_RS06025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K0E66_RS06025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K0E66_RS06030	COG0436	Aminotransferase
K0E66_RS06045	COG0826	peptidase U32
K0E66_RS06055	COG4771	TonB-dependent receptor
K0E66_RS06065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K0E66_RS06075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K0E66_RS06090	COG3206	protein involved in exopolysaccharide biosynthesis
K0E66_RS06090	COG0489	protein tyrosine kinase activity
K0E66_RS06100	COG0527	aspartate kinase activity
K0E66_RS06100	COG0460	homoserine dehydrogenase
K0E66_RS06105	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
K0E66_RS06160	COG4771	TonB-dependent receptor
K0E66_RS06165	COG0702	epimerase
K0E66_RS06175	COG3250	beta-galactosidase activity
K0E66_RS06185	COG3250	beta-galactosidase activity
K0E66_RS06190	COG3507	Belongs to the glycosyl hydrolase 43 family
K0E66_RS06205	COG4771	TonB-dependent receptor
K0E66_RS06220	COG2226	methyltransferase
K0E66_RS06265	COG0546	phosphoglycolate phosphatase activity
K0E66_RS06310	COG0628	permease
K0E66_RS06315	COG1435	thymidine kinase activity
K0E66_RS06325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K0E66_RS06340	COG2095	MarC family integral membrane protein
K0E66_RS06365	COG4974	Belongs to the 'phage' integrase family
K0E66_RS06370	COG4771	TonB-dependent receptor
K0E66_RS06380	COG4771	TonB-dependent receptor
K0E66_RS06385	COG0702	epimerase
K0E66_RS06390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K0E66_RS06405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K0E66_RS06405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K0E66_RS06420	COG0531	amino acid
K0E66_RS06430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K0E66_RS06435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K0E66_RS06440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K0E66_RS06475	COG1162	GTPase activity
K0E66_RS06480	COG0233	cytoplasmic translational termination
K0E66_RS06500	COG0443	Heat shock 70 kDa protein
K0E66_RS06520	COG0528	UMP kinase activity
K0E66_RS06525	COG0534	Mate efflux family protein
K0E66_RS06550	COG0792	nuclease activity
K0E66_RS06570	COG1183	phosphatidylcholine synthase activity
K0E66_RS06575	COG0688	phosphatidylethanolamine metabolic process
K0E66_RS06585	COG3118	belongs to the thioredoxin family
K0E66_RS06620	COG0714	Associated with various cellular activities
K0E66_RS06635	COG0802	atpase or kinase
K0E66_RS06640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K0E66_RS06650	COG2234	aminopeptidase activity
K0E66_RS06675	COG1629	transport
K0E66_RS06695	COG3250	beta-galactosidase activity
K0E66_RS06710	COG0784	Response regulator, receiver
K0E66_RS06710	COG2205	protein histidine kinase activity
K0E66_RS06725	COG1566	PFAM secretion protein HlyD family protein
K0E66_RS06745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K0E66_RS06760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K0E66_RS06765	COG0742	ribosomal rna small subunit methyltransferase
K0E66_RS06790	COG4771	TonB-dependent receptor
K0E66_RS06800	COG3537	Alpha-1,2-mannosidase
K0E66_RS06815	COG3537	Alpha-1,2-mannosidase
K0E66_RS06820	COG2814	Major facilitator Superfamily
K0E66_RS06840	COG0739	heme binding
K0E66_RS06850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K0E66_RS06855	COG1388	LysM domain
K0E66_RS06855	COG3942	CHAP domain
K0E66_RS06865	COG1475	DNA binding
K0E66_RS06870	COG1192	Involved in chromosome partitioning
K0E66_RS06875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K0E66_RS06880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K0E66_RS06895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K0E66_RS06900	COG0799	negative regulation of ribosome biogenesis
K0E66_RS06915	COG2239	Acts as a magnesium transporter
K0E66_RS06920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K0E66_RS06930	COG2195	Cleaves the N-terminal amino acid of tripeptides
K0E66_RS06985	COG0668	transmembrane transport
K0E66_RS06990	COG0662	Cupin 2, conserved barrel domain protein
K0E66_RS06990	COG2207	Transcriptional regulator
K0E66_RS07025	COG1215	transferase activity, transferring glycosyl groups
K0E66_RS07080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K0E66_RS07090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K0E66_RS07105	COG1028	Short-chain dehydrogenase reductase Sdr
K0E66_RS07110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K0E66_RS07115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K0E66_RS07130	COG1373	ATPase (AAA superfamily
K0E66_RS07135	COG0667	Aldo Keto reductase
K0E66_RS07140	COG1472	Belongs to the glycosyl hydrolase 3 family
K0E66_RS07145	COG4771	TonB-dependent receptor
K0E66_RS07155	COG0702	epimerase
K0E66_RS07195	COG5012	cobalamin binding
K0E66_RS07205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K0E66_RS07220	COG4124	Belongs to the glycosyl hydrolase 26 family
K0E66_RS07225	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K0E66_RS07230	COG2211	Major facilitator Superfamily
K0E66_RS07235	COG2942	2-epimerase
K0E66_RS07265	COG1404	Belongs to the peptidase S8 family
K0E66_RS07265	COG4412	M6 family metalloprotease domain protein
K0E66_RS07270	COG0784	Response regulator, receiver
K0E66_RS07270	COG2205	protein histidine kinase activity
K0E66_RS07270	COG5002	protein histidine kinase activity
K0E66_RS07280	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K0E66_RS07285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K0E66_RS07290	COG0713	ATP synthesis coupled electron transport
K0E66_RS07295	COG0839	Belongs to the complex I subunit 6 family
K0E66_RS07305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K0E66_RS07310	COG0649	NAD binding
K0E66_RS07310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K0E66_RS07315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K0E66_RS07320	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K0E66_RS07330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K0E66_RS07335	COG0569	domain protein
K0E66_RS07340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K0E66_RS07345	COG1073	alpha beta
K0E66_RS07360	COG0546	phosphoglycolate phosphatase activity
K0E66_RS07365	COG3119	arylsulfatase activity
K0E66_RS07380	COG3119	arylsulfatase activity
K0E66_RS07390	COG1629	transport
K0E66_RS07395	COG2205	protein histidine kinase activity
K0E66_RS07395	COG3292	Two component regulator propeller
K0E66_RS07395	COG0745	RESPONSE REGULATOR receiver
K0E66_RS07400	COG2271	Major facilitator Superfamily
K0E66_RS07420	COG0805	protein transport
K0E66_RS07425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K0E66_RS07430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K0E66_RS07460	COG4585	Histidine kinase
K0E66_RS07475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K0E66_RS07485	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K0E66_RS07490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K0E66_RS07490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K0E66_RS07495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K0E66_RS07500	COG1078	dGTPase activity
K0E66_RS07505	COG0284	orotidine-5'-phosphate decarboxylase activity
K0E66_RS07510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K0E66_RS07515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K0E66_RS07520	COG1704	LemA family
K0E66_RS07535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K0E66_RS07540	COG2226	methyltransferase
K0E66_RS07545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K0E66_RS07550	COG1702	phosphate starvation-inducible protein PhoH
K0E66_RS07560	COG2268	Band 7 protein
K0E66_RS07570	COG5434	Belongs to the glycosyl hydrolase 28 family
K0E66_RS07580	COG0101	tRNA pseudouridine synthase activity
K0E66_RS07600	COG3250	beta-galactosidase activity
K0E66_RS07605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K0E66_RS07625	COG0457	Tetratricopeptide repeat
K0E66_RS07630	COG2814	Major facilitator Superfamily
K0E66_RS07705	COG0358	DNA primase activity
K0E66_RS07840	COG2205	protein histidine kinase activity
K0E66_RS07840	COG2198	Histidine kinase
K0E66_RS07840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K0E66_RS07840	COG0784	Response regulator, receiver
K0E66_RS07870	COG3344	reverse transcriptase
K0E66_RS07885	COG0551	DNA topoisomerase type I activity
K0E66_RS07885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K0E66_RS07920	COG4974	Belongs to the 'phage' integrase family
K0E66_RS07950	COG0702	epimerase
K0E66_RS07955	COG4206	TonB-dependent receptor
K0E66_RS07955	COG1629	transport
K0E66_RS07970	COG1629	transport
K0E66_RS07970	COG4206	TonB-dependent receptor
K0E66_RS07980	COG4771	TonB-dependent receptor
K0E66_RS08000	COG4206	TonB-dependent receptor
K0E66_RS08000	COG1629	transport
K0E66_RS08010	COG0673	inositol 2-dehydrogenase activity
K0E66_RS08060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K0E66_RS08065	COG0793	Belongs to the peptidase S41A family
K0E66_RS08070	COG2131	deaminase
K0E66_RS08080	COG0339	signal peptide processing
K0E66_RS08105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K0E66_RS08105	COG0519	Catalyzes the synthesis of GMP from XMP
K0E66_RS08115	COG4206	TonB-dependent receptor
K0E66_RS08115	COG1629	transport
K0E66_RS08125	COG4771	TonB-dependent receptor
K0E66_RS08130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K0E66_RS08140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K0E66_RS08150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K0E66_RS08155	COG0823	Involved in the tonB-independent uptake of proteins
K0E66_RS08155	COG1506	peptidase
K0E66_RS08170	COG1242	4 iron, 4 sulfur cluster binding
K0E66_RS08180	COG0363	glucosamine-6-phosphate deaminase activity
K0E66_RS08190	COG0009	L-threonylcarbamoyladenylate synthase
K0E66_RS08200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K0E66_RS08205	COG0561	phosphatase activity
K0E66_RS08210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K0E66_RS08215	COG0626	cystathionine gamma-synthase activity
K0E66_RS08255	COG0438	transferase activity, transferring glycosyl groups
K0E66_RS08270	COG0297	glycogen (starch) synthase activity
K0E66_RS08275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K0E66_RS08280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K0E66_RS08285	COG0543	2 iron, 2 sulfur cluster binding
K0E66_RS08295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K0E66_RS08300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K0E66_RS08305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K0E66_RS08310	COG0546	phosphoglycolate phosphatase activity
K0E66_RS08315	COG0791	NLP P60 protein
K0E66_RS08320	COG1131	(ABC) transporter
K0E66_RS08330	COG0612	Peptidase, M16
K0E66_RS08335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K0E66_RS08340	COG1597	lipid kinase activity
K0E66_RS08345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K0E66_RS08355	COG1136	(ABC) transporter
K0E66_RS08375	COG2211	Major facilitator Superfamily
K0E66_RS08380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K0E66_RS08395	COG1674	ftsk spoiiie
K0E66_RS08405	COG0492	ferredoxin-NADP+ reductase activity
K0E66_RS08410	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS08445	COG1595	DNA-templated transcription, initiation
K0E66_RS08460	COG3956	TIGRFAM MazG family protein
K0E66_RS08470	COG0525	valine-tRNA ligase activity
K0E66_RS08490	COG4771	TonB-dependent receptor
K0E66_RS08505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K0E66_RS08520	COG4771	TonB-dependent receptor
K0E66_RS08525	COG0702	epimerase
K0E66_RS08530	COG3119	arylsulfatase activity
K0E66_RS08535	COG3119	arylsulfatase activity
K0E66_RS08555	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
K0E66_RS08565	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K0E66_RS08585	COG1253	flavin adenine dinucleotide binding
K0E66_RS08595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K0E66_RS08605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K0E66_RS08645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K0E66_RS08670	COG1086	Polysaccharide biosynthesis protein
K0E66_RS08675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K0E66_RS08680	COG1083	cytidylyl-transferase
K0E66_RS08690	COG1181	Belongs to the D-alanine--D-alanine ligase family
K0E66_RS08695	COG2089	acid synthase
K0E66_RS08720	COG0438	transferase activity, transferring glycosyl groups
K0E66_RS08745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K0E66_RS08760	COG4771	TonB-dependent receptor
K0E66_RS08765	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K0E66_RS08770	COG0563	adenylate kinase activity
K0E66_RS08775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K0E66_RS08780	COG1496	oxidoreductase activity
K0E66_RS08800	COG2706	6-phosphogluconolactonase activity
K0E66_RS08820	COG2207	Transcriptional regulator
K0E66_RS08840	COG1288	antiporter activity
K0E66_RS08875	COG0454	-acetyltransferase
K0E66_RS08880	COG0564	pseudouridine synthase activity
K0E66_RS08895	COG1501	Belongs to the glycosyl hydrolase 31 family
K0E66_RS08925	COG3011	Protein conserved in bacteria
K0E66_RS08940	COG0148	phosphopyruvate hydratase activity
K0E66_RS08950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K0E66_RS08955	COG1082	Xylose isomerase domain protein TIM barrel
K0E66_RS08975	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K0E66_RS08980	COG0193	aminoacyl-tRNA hydrolase activity
K0E66_RS08985	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K0E66_RS08995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K0E66_RS09000	COG1862	Preprotein translocase
K0E66_RS09010	COG0237	dephospho-CoA kinase activity
K0E66_RS09025	COG0542	response to heat
K0E66_RS09035	COG0583	DNA-binding transcription factor activity
K0E66_RS09040	COG2855	membrane
K0E66_RS09055	COG1595	DNA-templated transcription, initiation
K0E66_RS09070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K0E66_RS09090	COG4139	cobalamin transport
K0E66_RS09095	COG4974	Belongs to the 'phage' integrase family
K0E66_RS09160	COG4974	Belongs to the 'phage' integrase family
K0E66_RS09200	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K0E66_RS09210	COG0500	methyltransferase
K0E66_RS09225	COG0202	RNA polymerase activity
K0E66_RS09325	COG4974	Belongs to the 'phage' integrase family
K0E66_RS09445	COG1475	DNA binding
K0E66_RS09460	COG1192	Involved in chromosome partitioning
K0E66_RS09480	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K0E66_RS09495	COG0629	single-stranded DNA binding
K0E66_RS09530	COG3344	reverse transcriptase
K0E66_RS09560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K0E66_RS09570	COG2197	response regulator
K0E66_RS09575	COG0739	heme binding
K0E66_RS09575	COG0741	lytic transglycosylase activity
K0E66_RS09575	COG1196	nuclear chromosome segregation
K0E66_RS09640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K0E66_RS09645	COG1705	Flagellar rod assembly protein muramidase FlgJ
K0E66_RS09645	COG1388	LysM domain
K0E66_RS09760	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS09820	COG2755	lipolytic protein G-D-S-L family
K0E66_RS09820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K0E66_RS09960	COG0443	Heat shock 70 kDa protein
K0E66_RS09980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K0E66_RS10030	COG1917	Cupin 2, conserved barrel domain protein
K0E66_RS10030	COG4977	sequence-specific DNA binding
K0E66_RS10035	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K0E66_RS10110	COG0110	maltose O-acetyltransferase activity
K0E66_RS10115	COG1028	Short-chain dehydrogenase reductase Sdr
K0E66_RS10120	COG1917	Cupin 2, conserved barrel domain protein
K0E66_RS10120	COG2207	Transcriptional regulator
K0E66_RS10150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K0E66_RS10155	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K0E66_RS10160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K0E66_RS10175	COG1501	Belongs to the glycosyl hydrolase 31 family
K0E66_RS10215	COG1408	metallophosphoesterase
K0E66_RS10230	COG3634	alkyl hydroperoxide reductase activity
K0E66_RS10260	COG1760	l-serine dehydratase
K0E66_RS10265	COG0598	Magnesium transport protein CorA
K0E66_RS10270	COG1193	negative regulation of DNA recombination
K0E66_RS10285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K0E66_RS10290	COG2195	Cleaves the N-terminal amino acid of tripeptides
K0E66_RS10295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K0E66_RS10300	COG3189	MarR family transcriptional regulator
K0E66_RS10305	COG2885	chlorophyll binding
K0E66_RS10315	COG2217	Heavy metal translocating P-type atpase
K0E66_RS10320	COG2855	membrane
K0E66_RS10330	COG4206	TonB-dependent receptor
K0E66_RS10330	COG1629	transport
K0E66_RS10340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K0E66_RS10340	COG2207	Transcriptional regulator
K0E66_RS10360	COG4651	solute:proton antiporter activity
K0E66_RS10360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K0E66_RS10365	COG1280	lysine exporter protein (LysE YggA)
K0E66_RS10380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K0E66_RS10385	COG0561	phosphatase activity
K0E66_RS10390	COG1169	isochorismate synthase
K0E66_RS10395	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K0E66_RS10405	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K0E66_RS10410	COG4948	Mandelate Racemase Muconate Lactonizing
K0E66_RS10425	COG1082	Xylose isomerase domain protein TIM barrel
K0E66_RS10440	COG4771	TonB-dependent receptor
K0E66_RS10470	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K0E66_RS10475	COG0783	Belongs to the Dps family
K0E66_RS10500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K0E66_RS10565	COG0358	DNA primase activity
K0E66_RS10600	COG0156	8-amino-7-oxononanoate synthase activity
K0E66_RS10625	COG0542	response to heat
K0E66_RS10755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K0E66_RS10755	COG2755	lipolytic protein G-D-S-L family
K0E66_RS10780	COG1253	flavin adenine dinucleotide binding
K0E66_RS10785	COG0501	Belongs to the peptidase M48B family
K0E66_RS10810	COG2873	o-acetylhomoserine
K0E66_RS10830	COG1757	Na H antiporter
K0E66_RS10845	COG2814	Major facilitator Superfamily
K0E66_RS10850	COG4953	penicillin-binding protein 1C
K0E66_RS10855	COG2373	Large extracellular alpha-helical protein
K0E66_RS10865	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K0E66_RS10865	COG1918	ferrous iron import across plasma membrane
K0E66_RS10925	COG1086	Polysaccharide biosynthesis protein
K0E66_RS10930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K0E66_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
K0E66_RS10955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K0E66_RS10985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K0E66_RS10990	COG1216	Glycosyl transferase, family 2
K0E66_RS10990	COG0463	Glycosyl transferase, family 2
K0E66_RS11000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K0E66_RS11020	COG0471	metal ion transport
K0E66_RS11020	COG0490	domain, Protein
K0E66_RS11035	COG0346	lactoylglutathione lyase activity
K0E66_RS11050	COG0259	pyridoxamine-phosphate oxidase activity
K0E66_RS11055	COG1741	Belongs to the pirin family
K0E66_RS11070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K0E66_RS11100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K0E66_RS11110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K0E66_RS11125	COG1595	DNA-templated transcription, initiation
K0E66_RS11150	COG0686	Belongs to the AlaDH PNT family
K0E66_RS11165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K0E66_RS11200	COG0488	(ABC) transporter
K0E66_RS11205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K0E66_RS11210	COG3059	membrane
K0E66_RS11215	COG2207	Transcriptional regulator
K0E66_RS11215	COG0662	Cupin 2, conserved barrel domain protein
K0E66_RS11220	COG0295	cytidine deaminase activity
K0E66_RS11225	COG1388	LysM domain
K0E66_RS11225	COG1705	Flagellar rod assembly protein muramidase FlgJ
K0E66_RS11235	COG0577	efflux transmembrane transporter activity
K0E66_RS11245	COG0577	efflux transmembrane transporter activity
K0E66_RS11255	COG0577	efflux transmembrane transporter activity
K0E66_RS11265	COG0577	efflux transmembrane transporter activity
K0E66_RS11265	COG1136	(ABC) transporter
K0E66_RS11275	COG2207	Transcriptional regulator
K0E66_RS11275	COG0662	Cupin 2, conserved barrel domain protein
K0E66_RS11290	COG1136	(ABC) transporter
K0E66_RS11295	COG1136	(ABC) transporter
K0E66_RS11315	COG0784	Response regulator, receiver
K0E66_RS11315	COG2205	protein histidine kinase activity
K0E66_RS11325	COG2204	response regulator
K0E66_RS11330	COG4191	Histidine kinase
K0E66_RS11380	COG0732	type I restriction modification DNA specificity domain
K0E66_RS11390	COG4974	Belongs to the 'phage' integrase family
K0E66_RS11415	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K0E66_RS11440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K0E66_RS11460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K0E66_RS11465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K0E66_RS11475	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K0E66_RS11480	COG1216	Glycosyl transferase, family 2
K0E66_RS11480	COG1442	glycosyl transferase family 8
K0E66_RS11490	COG1086	Polysaccharide biosynthesis protein
K0E66_RS11500	COG1091	dTDP-4-dehydrorhamnose reductase activity
K0E66_RS11510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS11515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K0E66_RS11520	COG1530	ribonuclease E activity
K0E66_RS11535	COG3119	arylsulfatase activity
K0E66_RS11540	COG0629	single-stranded DNA binding
K0E66_RS11605	COG4206	TonB-dependent receptor
K0E66_RS11625	COG0745	RESPONSE REGULATOR receiver
K0E66_RS11650	COG0488	(ABC) transporter
K0E66_RS11665	COG5492	domain, Protein
K0E66_RS11675	COG0436	Aminotransferase
K0E66_RS11680	COG4591	ABC-type transport system involved in lipoprotein release permease component
K0E66_RS11685	COG1215	transferase activity, transferring glycosyl groups
K0E66_RS11690	COG0628	permease
K0E66_RS11695	COG3852	Histidine kinase
K0E66_RS11710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K0E66_RS11720	COG0577	efflux transmembrane transporter activity
K0E66_RS11720	COG1136	(ABC) transporter
K0E66_RS11725	COG1136	(ABC) transporter
K0E66_RS11725	COG0577	efflux transmembrane transporter activity
K0E66_RS11730	COG1252	NADH dehydrogenase
K0E66_RS11760	COG4771	TonB-dependent receptor
K0E66_RS11770	COG1620	l-lactate permease
K0E66_RS11790	COG2885	chlorophyll binding
K0E66_RS11790	COG3047	cAMP biosynthetic process
K0E66_RS11800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K0E66_RS11805	COG0439	Biotin carboxylase
K0E66_RS11810	COG0511	ligase activity, forming carbon-carbon bonds
K0E66_RS11820	COG2226	methyltransferase
K0E66_RS11825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K0E66_RS11860	COG0784	Response regulator, receiver
K0E66_RS11860	COG2205	protein histidine kinase activity
K0E66_RS11865	COG0508	dehydrogenase complex catalyzes the overall conversion of
K0E66_RS11870	COG0022	dehydrogenase e1 component
K0E66_RS11875	COG0716	FMN binding
K0E66_RS11880	COG2264	protein methyltransferase activity
K0E66_RS11895	COG0590	tRNA wobble adenosine to inosine editing
K0E66_RS11925	COG0673	inositol 2-dehydrogenase activity
K0E66_RS11930	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K0E66_RS11970	COG0698	ribose 5-phosphate isomerase
K0E66_RS11975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K0E66_RS11980	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K0E66_RS11995	COG1482	cell wall glycoprotein biosynthetic process
K0E66_RS12015	COG0513	Belongs to the DEAD box helicase family
K0E66_RS12020	COG4221	oxidoreductase activity
K0E66_RS12030	COG3250	beta-galactosidase activity
K0E66_RS12040	COG0471	metal ion transport
K0E66_RS12040	COG3273	potassium ion transport
K0E66_RS12045	COG0529	Catalyzes the synthesis of activated sulfate
K0E66_RS12050	COG0175	sulfate reduction
K0E66_RS12070	COG2885	chlorophyll binding
K0E66_RS12140	COG2204	response regulator
K0E66_RS12145	COG0784	Response regulator, receiver
K0E66_RS12145	COG2205	protein histidine kinase activity
K0E66_RS12155	COG1538	Outer membrane efflux protein
K0E66_RS12165	COG1566	PFAM secretion protein HlyD family protein
K0E66_RS12170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K0E66_RS12215	COG4974	Belongs to the 'phage' integrase family
K0E66_RS12250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K0E66_RS12255	COG0242	peptide deformylase activity
K0E66_RS12270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K0E66_RS12275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K0E66_RS12280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K0E66_RS12285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K0E66_RS12295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K0E66_RS12300	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K0E66_RS12305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K0E66_RS12305	COG0674	pyruvate-flavodoxin oxidoreductase activity
K0E66_RS12305	COG1013	pyruvate-flavodoxin oxidoreductase activity
K0E66_RS12305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K0E66_RS12315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K0E66_RS12355	COG1940	carbohydrate kinase activity
K0E66_RS12360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K0E66_RS12370	COG2271	Major facilitator Superfamily
K0E66_RS12375	COG2731	YhcH YjgK YiaL family protein
K0E66_RS12380	COG1629	transport
K0E66_RS12385	COG0702	epimerase
K0E66_RS12400	COG1629	transport
K0E66_RS12405	COG0702	epimerase
K0E66_RS12415	COG4771	TonB-dependent receptor
K0E66_RS12420	COG0702	epimerase
K0E66_RS12425	COG0702	epimerase
K0E66_RS12430	COG4206	TonB-dependent receptor
K0E66_RS12430	COG1629	transport
K0E66_RS12435	COG4206	TonB-dependent receptor
K0E66_RS12435	COG1629	transport
K0E66_RS12450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS12470	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS12480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS12485	COG3537	Alpha-1,2-mannosidase
K0E66_RS12490	COG3250	beta-galactosidase activity
K0E66_RS12495	COG4771	TonB-dependent receptor
K0E66_RS12500	COG0702	epimerase
K0E66_RS12505	COG0484	heat shock protein binding
K0E66_RS12510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K0E66_RS12515	COG0488	(ABC) transporter
K0E66_RS12520	COG1595	DNA-templated transcription, initiation
K0E66_RS12615	COG2885	chlorophyll binding
K0E66_RS12720	COG2183	response to ionizing radiation
K0E66_RS12725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K0E66_RS12725	COG2205	protein histidine kinase activity
K0E66_RS12730	COG0737	Belongs to the 5'-nucleotidase family
K0E66_RS12735	COG1956	GAF domain-containing protein
K0E66_RS12745	COG4771	TonB-dependent receptor
K0E66_RS12770	COG0534	Mate efflux family protein
K0E66_RS12815	COG0534	Mate efflux family protein
K0E66_RS12825	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K0E66_RS12835	COG0318	PFAM AMP-dependent synthetase and ligase
K0E66_RS12840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS12845	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K0E66_RS12910	COG1086	Polysaccharide biosynthesis protein
K0E66_RS12920	COG1091	dTDP-4-dehydrorhamnose reductase activity
K0E66_RS12930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS12955	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K0E66_RS12960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K0E66_RS12965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K0E66_RS12970	COG0363	glucosamine-6-phosphate deaminase activity
K0E66_RS13095	COG3279	Response regulator of the LytR AlgR family
K0E66_RS13105	COG0577	efflux transmembrane transporter activity
K0E66_RS13105	COG1136	(ABC) transporter
K0E66_RS13110	COG1136	(ABC) transporter
K0E66_RS13115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K0E66_RS13150	COG4884	unkown
K0E66_RS13150	COG3831	ATPase activity
K0E66_RS13165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K0E66_RS13175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K0E66_RS13180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K0E66_RS13185	COG3250	beta-galactosidase activity
K0E66_RS13210	COG0501	Belongs to the peptidase M48B family
K0E66_RS13215	COG1704	LemA family
K0E66_RS13240	COG4206	TonB-dependent receptor
K0E66_RS13240	COG1629	transport
K0E66_RS13250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K0E66_RS13255	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K0E66_RS13255	COG2885	chlorophyll binding
K0E66_RS13265	COG0697	spore germination
K0E66_RS13295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K0E66_RS13300	COG0656	L-ascorbic acid biosynthetic process
K0E66_RS13310	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K0E66_RS13315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K0E66_RS13320	COG2814	Major facilitator Superfamily
K0E66_RS13325	COG4771	TonB-dependent receptor
K0E66_RS13350	COG4771	TonB-dependent receptor
K0E66_RS13395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K0E66_RS13400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K0E66_RS13470	COG0488	(ABC) transporter
K0E66_RS13490	COG2205	protein histidine kinase activity
K0E66_RS13490	COG0784	Response regulator, receiver
K0E66_RS13505	COG0438	transferase activity, transferring glycosyl groups
K0E66_RS13515	COG0438	transferase activity, transferring glycosyl groups
K0E66_RS13525	COG2244	polysaccharide biosynthetic process
K0E66_RS13535	COG1216	Glycosyl transferase, family 2
K0E66_RS13535	COG1442	glycosyl transferase family 8
K0E66_RS13550	COG1215	transferase activity, transferring glycosyl groups
K0E66_RS13580	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K0E66_RS13585	COG1805	sodium ion transport
K0E66_RS13590	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K0E66_RS13615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K0E66_RS13620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K0E66_RS13630	COG0545	Peptidyl-prolyl cis-trans isomerase
K0E66_RS13635	COG1739	Uncharacterized protein family UPF0029
K0E66_RS13645	COG0778	Nitroreductase
K0E66_RS13650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K0E66_RS13650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K0E66_RS13655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K0E66_RS13685	COG2217	Heavy metal translocating P-type atpase
K0E66_RS13695	COG0321	lipoyl(octanoyl) transferase activity
K0E66_RS13715	COG3852	Histidine kinase
K0E66_RS13720	COG2204	response regulator
K0E66_RS13735	COG1136	(ABC) transporter
K0E66_RS13750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K0E66_RS13760	COG1755	Isoprenylcysteine carboxyl methyltransferase
K0E66_RS13770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K0E66_RS13785	COG1678	Uncharacterized ACR, COG1678
K0E66_RS13825	COG4771	TonB-dependent receptor
K0E66_RS13835	COG3119	arylsulfatase activity
K0E66_RS13840	COG3250	beta-galactosidase activity
K0E66_RS13850	COG0681	Belongs to the peptidase S26 family
K0E66_RS13880	COG3969	phosphoadenosine phosphosulfate
K0E66_RS13885	COG1475	DNA binding
K0E66_RS13925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS13930	COG0745	RESPONSE REGULATOR receiver
K0E66_RS13945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS13955	COG4206	TonB-dependent receptor
K0E66_RS13955	COG1629	transport
K0E66_RS13965	COG4974	Belongs to the 'phage' integrase family
K0E66_RS14060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K0E66_RS14080	COG1022	Amp-dependent synthetase and ligase
K0E66_RS14085	COG3263	regulation of cellular component size
K0E66_RS14095	COG1151	hydroxylamine reductase activity
K0E66_RS14110	COG2204	response regulator
K0E66_RS14130	COG1136	(ABC) transporter
K0E66_RS14130	COG0577	efflux transmembrane transporter activity
K0E66_RS14140	COG1136	(ABC) transporter
K0E66_RS14140	COG0577	efflux transmembrane transporter activity
K0E66_RS14150	COG0534	Mate efflux family protein
K0E66_RS14160	COG0167	dihydroorotate dehydrogenase activity
K0E66_RS14165	COG2755	lipolytic protein G-D-S-L family
K0E66_RS14165	COG0657	acetylesterase activity
K0E66_RS14170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K0E66_RS14185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K0E66_RS14200	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K0E66_RS14210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K0E66_RS14220	COG0356	it plays a direct role in the translocation of protons across the membrane
K0E66_RS14225	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K0E66_RS14230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K0E66_RS14235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K0E66_RS14240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K0E66_RS14245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K0E66_RS14250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K0E66_RS14255	COG3118	belongs to the thioredoxin family
K0E66_RS14275	COG0745	RESPONSE REGULATOR receiver
K0E66_RS14280	COG5002	protein histidine kinase activity
K0E66_RS14310	COG1120	ATPase activity
K0E66_RS14315	COG1091	dTDP-4-dehydrorhamnose reductase activity
K0E66_RS14365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K0E66_RS14370	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K0E66_RS14390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K0E66_RS14395	COG1064	alcohol dehydrogenase
K0E66_RS14410	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K0E66_RS14420	COG2205	protein histidine kinase activity
K0E66_RS14420	COG2202	Pas domain
K0E66_RS14425	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K0E66_RS14435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K0E66_RS14450	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K0E66_RS14455	COG0540	Belongs to the ATCase OTCase family
K0E66_RS14465	COG2431	L-lysine efflux transmembrane transporter activity
K0E66_RS14490	COG2837	iron assimilation
K0E66_RS14500	COG4206	TonB-dependent receptor
K0E66_RS14500	COG1629	transport
K0E66_RS14520	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K0E66_RS14530	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K0E66_RS14545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K0E66_RS14550	COG2205	protein histidine kinase activity
K0E66_RS14570	COG2135	peptidase activity
K0E66_RS14580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K0E66_RS14585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K0E66_RS14605	COG0673	inositol 2-dehydrogenase activity
K0E66_RS14615	COG2223	nitrite transmembrane transporter activity
K0E66_RS14635	COG0671	phosphoesterase, PA-phosphatase related
K0E66_RS14650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K0E66_RS14655	COG0045	succinate-CoA ligase (ADP-forming) activity
K0E66_RS14660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K0E66_RS14665	COG0351	phosphomethylpyrimidine kinase
K0E66_RS14690	COG0477	Major facilitator Superfamily
K0E66_RS14690	COG2814	Major facilitator Superfamily
K0E66_RS14700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K0E66_RS14700	COG3153	acetyltransferase
K0E66_RS14705	COG0450	alkyl hydroperoxide reductase
K0E66_RS14710	COG0724	RNA recognition motif
K0E66_RS14715	COG1858	cytochrome C peroxidase
K0E66_RS14720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K0E66_RS14740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K0E66_RS14750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K0E66_RS14765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K0E66_RS14845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K0E66_RS14855	COG1904	glucuronate isomerase
K0E66_RS14885	COG0513	Belongs to the DEAD box helicase family
K0E66_RS14890	COG0560	Phosphoserine phosphatase
K0E66_RS14890	COG3830	Belongs to the UPF0237 family
K0E66_RS14910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K0E66_RS14915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K0E66_RS14960	COG2204	response regulator
K0E66_RS15005	COG1136	(ABC) transporter
K0E66_RS15005	COG0577	efflux transmembrane transporter activity
K0E66_RS15015	COG0156	8-amino-7-oxononanoate synthase activity
K0E66_RS15020	COG1597	lipid kinase activity
K0E66_RS15025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K0E66_RS15050	COG0577	efflux transmembrane transporter activity
K0E66_RS15050	COG1136	(ABC) transporter
K0E66_RS15075	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K0E66_RS15105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K0E66_RS15120	COG0543	2 iron, 2 sulfur cluster binding
K0E66_RS15125	COG0167	dihydroorotate dehydrogenase activity
K0E66_RS15130	COG0336	Belongs to the RNA methyltransferase TrmD family
K0E66_RS15135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K0E66_RS15140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K0E66_RS15165	COG0326	Molecular chaperone. Has ATPase activity
K0E66_RS15170	COG0542	response to heat
K0E66_RS15215	COG2304	oxidoreductase activity
K0E66_RS15230	COG0714	Associated with various cellular activities
K0E66_RS15235	COG1652	LysM domain
K0E66_RS15245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K0E66_RS15250	COG0552	protein localization to endoplasmic reticulum
K0E66_RS15260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K0E66_RS15265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K0E66_RS15270	COG1058	Belongs to the CinA family
K0E66_RS15270	COG1546	Belongs to the CinA family
K0E66_RS15275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K0E66_RS15290	COG0442	prolyl-tRNA aminoacylation
K0E66_RS15305	COG0793	Belongs to the peptidase S41A family
K0E66_RS15305	COG4946	Tricorn protease homolog
K0E66_RS15320	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K0E66_RS15335	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K0E66_RS15345	COG1492	cobalamin metabolic process
K0E66_RS15370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K0E66_RS15390	COG2096	Adenosyltransferase
K0E66_RS15395	COG1797	cobyrinic acid a,c-diamide synthase activity
K0E66_RS15410	COG2966	Psort location CytoplasmicMembrane, score
K0E66_RS15415	COG4771	TonB-dependent receptor
K0E66_RS15425	COG4774	siderophore transport
K0E66_RS15450	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K0E66_RS15520	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K0E66_RS15525	COG4974	Belongs to the 'phage' integrase family
K0E66_RS15590	COG4771	TonB-dependent receptor
K0E66_RS15605	COG2885	chlorophyll binding
K0E66_RS15675	COG0305	Participates in initiation and elongation during chromosome replication
K0E66_RS15685	COG3023	N-Acetylmuramoyl-L-alanine amidase
K0E66_RS15740	COG0352	thiamine-phosphate diphosphorylase activity
K0E66_RS15745	COG2022	thiamine diphosphate biosynthetic process
K0E66_RS15750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K0E66_RS15765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K0E66_RS15770	COG0352	thiamine-phosphate diphosphorylase activity
K0E66_RS15805	COG0358	DNA primase activity
K0E66_RS15875	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K0E66_RS15925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K0E66_RS16050	COG1192	Involved in chromosome partitioning
K0E66_RS16060	COG1401	restriction endodeoxyribonuclease activity
K0E66_RS16085	COG0574	Belongs to the PEP-utilizing enzyme family
K0E66_RS16085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K0E66_RS16090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K0E66_RS16095	COG0564	pseudouridine synthase activity
K0E66_RS16110	COG0024	Methionine aminopeptidase
K0E66_RS16135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K0E66_RS16145	COG0481	GTPase activity
K0E66_RS16165	COG0708	Exodeoxyribonuclease III
K0E66_RS16170	COG1914	H( )-stimulated, divalent metal cation uptake system
K0E66_RS16185	COG0217	transcriptional regulatory protein
K0E66_RS16190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K0E66_RS16190	COG0072	phenylalanine-tRNA ligase activity
K0E66_RS16195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K0E66_RS16200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS16220	COG1216	Glycosyl transferase, family 2
K0E66_RS16225	COG1216	Glycosyl transferase, family 2
K0E66_RS16245	COG0028	Belongs to the TPP enzyme family
K0E66_RS16250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS16260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K0E66_RS16300	COG0305	Participates in initiation and elongation during chromosome replication
K0E66_RS16305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K0E66_RS16320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K0E66_RS16325	COG4657	Part of a membrane complex involved in electron transport
K0E66_RS16330	COG4660	Part of a membrane complex involved in electron transport
K0E66_RS16335	COG4659	FMN binding
K0E66_RS16340	COG4658	electron transport chain
K0E66_RS16345	COG4656	Part of a membrane complex involved in electron transport
K0E66_RS16370	COG0504	CTP synthase activity
K0E66_RS16380	COG0534	Mate efflux family protein
K0E66_RS16385	COG1506	peptidase
K0E66_RS16385	COG0823	Involved in the tonB-independent uptake of proteins
K0E66_RS16400	COG0110	maltose O-acetyltransferase activity
K0E66_RS16410	COG1695	Transcriptional regulator
K0E66_RS16425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K0E66_RS16435	COG3942	CHAP domain
K0E66_RS16435	COG1388	LysM domain
K0E66_RS16465	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K0E66_RS16485	COG0556	nucleotide-excision repair
K0E66_RS16490	COG2949	membrane
K0E66_RS16510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K0E66_RS16525	COG2205	protein histidine kinase activity
K0E66_RS16525	COG0784	Response regulator, receiver
K0E66_RS16530	COG0842	Transport permease protein
K0E66_RS16535	COG0842	Transport permease protein
K0E66_RS16540	COG1131	(ABC) transporter
K0E66_RS16575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K0E66_RS16580	COG0505	Belongs to the CarA family
K0E66_RS16590	COG0067	glutamate synthase
K0E66_RS16590	COG0069	glutamate synthase activity
K0E66_RS16590	COG0070	glutamate synthase
K0E66_RS16600	COG0367	asparagine synthase
K0E66_RS16615	COG3275	phosphorelay sensor kinase activity
K0E66_RS16645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K0E66_RS16655	COG1979	alcohol dehydrogenase
K0E66_RS16660	COG0133	tryptophan synthase activity
K0E66_RS16665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K0E66_RS16680	COG0134	indole-3-glycerol-phosphate synthase activity
K0E66_RS16685	COG0135	phosphoribosylanthranilate isomerase activity
K0E66_RS16690	COG0159	tryptophan synthase activity
K0E66_RS16695	COG0252	asparaginase activity
K0E66_RS16705	COG2205	protein histidine kinase activity
K0E66_RS16705	COG0745	RESPONSE REGULATOR receiver
K0E66_RS16705	COG3292	Two component regulator propeller
K0E66_RS16710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K0E66_RS16720	COG0110	maltose O-acetyltransferase activity
K0E66_RS16725	COG2197	response regulator
K0E66_RS16735	COG0138	bifunctional purine biosynthesis protein purh
K0E66_RS16740	COG0716	FMN binding
K0E66_RS16765	COG1858	cytochrome C peroxidase
K0E66_RS16775	COG4771	TonB-dependent receptor
K0E66_RS16790	COG2814	Major facilitator Superfamily
K0E66_RS16795	COG1566	PFAM secretion protein HlyD family protein
K0E66_RS16805	COG1230	cation diffusion facilitator family transporter
K0E66_RS16825	COG4771	TonB-dependent receptor
K0E66_RS16855	COG3610	response to peptide
K0E66_RS16870	COG1609	Transcriptional regulator
K0E66_RS16880	COG1733	regulation of RNA biosynthetic process
K0E66_RS16890	COG2205	protein histidine kinase activity
K0E66_RS16890	COG2198	Histidine kinase
K0E66_RS16890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K0E66_RS16890	COG0784	Response regulator, receiver
K0E66_RS16900	COG5002	protein histidine kinase activity
K0E66_RS16905	COG0745	RESPONSE REGULATOR receiver
K0E66_RS16925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K0E66_RS16930	COG1690	Belongs to the RtcB family
K0E66_RS16945	COG0228	four-way junction DNA binding
K0E66_RS16960	COG0724	RNA recognition motif
K0E66_RS16970	COG1177	transmembrane transport
K0E66_RS16975	COG1176	ABC-type spermidine putrescine transport system, permease component I
K0E66_RS16985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K0E66_RS16995	COG0058	SHG alpha-glucan phosphorylase activity
K0E66_RS17005	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K0E66_RS17025	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K0E66_RS17075	COG0745	RESPONSE REGULATOR receiver
K0E66_RS17080	COG5002	protein histidine kinase activity
K0E66_RS17105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K0E66_RS17110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K0E66_RS17125	COG4948	Mandelate Racemase Muconate Lactonizing
K0E66_RS17140	COG1295	ribonuclease BN
K0E66_RS17145	COG0778	Nitroreductase
K0E66_RS17155	COG0704	Plays a role in the regulation of phosphate uptake
K0E66_RS17160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K0E66_RS17165	COG0581	inorganic phosphate transmembrane transporter activity
K0E66_RS17170	COG0573	inorganic phosphate transmembrane transporter activity
K0E66_RS17180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K0E66_RS17200	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K0E66_RS17235	COG3023	N-Acetylmuramoyl-L-alanine amidase
K0E66_RS17285	COG1216	Glycosyl transferase, family 2
K0E66_RS17290	COG1216	Glycosyl transferase, family 2
K0E66_RS17295	COG1216	Glycosyl transferase, family 2
K0E66_RS17325	COG1216	Glycosyl transferase, family 2
K0E66_RS17335	COG1045	serine acetyltransferase
K0E66_RS17355	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K0E66_RS17400	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K0E66_RS17400	COG0662	Cupin 2, conserved barrel domain protein
K0E66_RS17405	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K0E66_RS17425	COG1363	Peptidase, m42
K0E66_RS17465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K0E66_RS17470	COG0167	dihydroorotate dehydrogenase activity
K0E66_RS17535	COG5002	protein histidine kinase activity
K0E66_RS17550	COG2172	sigma factor antagonist activity
K0E66_RS17575	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K0E66_RS17595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K0E66_RS17600	COG0497	DNA recombination
K0E66_RS17610	COG2176	DNA-directed DNA polymerase activity
K0E66_RS17610	COG5002	protein histidine kinase activity
K0E66_RS17615	COG0592	DNA-directed DNA polymerase activity
K0E66_RS17630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K0E66_RS17630	COG0321	lipoyl(octanoyl) transferase activity
K0E66_RS17645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS17650	COG0156	8-amino-7-oxononanoate synthase activity
K0E66_RS17755	COG0019	diaminopimelate decarboxylase activity
K0E66_RS17760	COG0527	aspartate kinase activity
K0E66_RS17765	COG2884	Cell division ATP-binding protein ftsE
K0E66_RS17770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K0E66_RS17770	COG0140	phosphoribosyl-ATP diphosphatase activity
K0E66_RS17775	COG0107	imidazoleglycerol-phosphate synthase activity
K0E66_RS17780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K0E66_RS17805	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K0E66_RS17855	COG2197	response regulator
K0E66_RS17875	COG3586	endonuclease activity
K0E66_RS17900	COG4977	sequence-specific DNA binding
K0E66_RS17900	COG1917	Cupin 2, conserved barrel domain protein
K0E66_RS17910	COG0693	protein deglycase activity
K0E66_RS17925	COG0494	nUDIX hydrolase
K0E66_RS17935	COG3326	Membrane
K0E66_RS18035	COG0561	phosphatase activity
K0E66_RS18040	COG1629	transport
K0E66_RS18040	COG4206	TonB-dependent receptor
K0E66_RS18100	COG0363	glucosamine-6-phosphate deaminase activity
K0E66_RS18105	COG2365	Tyrosine phosphatase family
K0E66_RS18140	COG1032	radical SAM domain protein
K0E66_RS18145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K0E66_RS18150	COG0463	Glycosyl transferase, family 2
K0E66_RS18155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K0E66_RS18160	COG0646	methionine synthase
K0E66_RS18160	COG1410	methionine synthase
K0E66_RS18200	COG1408	metallophosphoesterase
K0E66_RS18205	COG1132	(ABC) transporter
K0E66_RS18210	COG1132	(ABC) transporter
K0E66_RS18220	COG0420	3'-5' exonuclease activity
K0E66_RS18255	COG0681	Belongs to the peptidase S26 family
K0E66_RS18345	COG0641	radical SAM
K0E66_RS18350	COG3591	Belongs to the peptidase S1B family
K0E66_RS18355	COG3591	Belongs to the peptidase S1B family
K0E66_RS18390	COG1773	rubredoxin
K0E66_RS18390	COG1592	Rubrerythrin
K0E66_RS18400	COG3152	Membrane
K0E66_RS18405	COG0339	signal peptide processing
K0E66_RS18410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K0E66_RS18410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K0E66_RS18420	COG1629	transport
K0E66_RS18420	COG4206	TonB-dependent receptor
K0E66_RS18435	COG0131	Imidazoleglycerol-phosphate dehydratase
K0E66_RS18435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K0E66_RS18445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K0E66_RS18450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K0E66_RS18460	COG1741	Belongs to the pirin family
K0E66_RS18465	COG4232	protein-disulfide reductase activity
K0E66_RS18475	COG0572	uridine kinase
K0E66_RS18480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K0E66_RS18485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K0E66_RS18495	COG1410	methionine synthase
K0E66_RS18495	COG0646	methionine synthase
K0E66_RS18500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K0E66_RS18535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K0E66_RS18545	COG1295	ribonuclease BN
K0E66_RS18555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K0E66_RS18560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K0E66_RS18565	COG0247	lactate metabolic process
K0E66_RS18565	COG0277	FAD linked oxidase domain protein
K0E66_RS18675	COG2205	protein histidine kinase activity
K0E66_RS18675	COG3437	response regulator, receiver
K0E66_RS18675	COG3850	Histidine kinase
K0E66_RS18675	COG4999	Histidine kinase
K0E66_RS18680	COG2205	protein histidine kinase activity
K0E66_RS18680	COG2202	Pas domain
K0E66_RS18685	COG0534	Mate efflux family protein
K0E66_RS18690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K0E66_RS18695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K0E66_RS18700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K0E66_RS18760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K0E66_RS18800	COG2195	Cleaves the N-terminal amino acid of tripeptides
K0E66_RS18810	COG0668	transmembrane transport
K0E66_RS18815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K0E66_RS18825	COG3250	beta-galactosidase activity
K0E66_RS18830	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS18835	COG3119	arylsulfatase activity
K0E66_RS18840	COG3119	arylsulfatase activity
K0E66_RS18845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS18850	COG2205	protein histidine kinase activity
K0E66_RS18850	COG0745	RESPONSE REGULATOR receiver
K0E66_RS18850	COG3292	Two component regulator propeller
K0E66_RS18855	COG1830	Aldolase
K0E66_RS18860	COG0588	phosphoglycerate mutase activity
K0E66_RS18865	COG1119	ATPase activity
K0E66_RS18870	COG3119	arylsulfatase activity
K0E66_RS18875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS18885	COG4206	TonB-dependent receptor
K0E66_RS18885	COG1629	transport
K0E66_RS18900	COG1523	belongs to the glycosyl hydrolase 13 family
K0E66_RS18905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K0E66_RS18925	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K0E66_RS18940	COG0126	phosphoglycerate kinase activity
K0E66_RS18955	COG2311	Membrane
K0E66_RS19005	COG0424	maF-like protein
K0E66_RS19010	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K0E66_RS19025	COG0778	Nitroreductase
K0E66_RS19030	COG0288	reversible hydration of carbon dioxide
K0E66_RS19045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K0E66_RS19055	COG0511	ligase activity, forming carbon-carbon bonds
K0E66_RS19055	COG5016	pyruvate
K0E66_RS19060	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K0E66_RS19075	COG0366	Alpha amylase catalytic
K0E66_RS19095	COG0191	fructose-bisphosphate aldolase activity
K0E66_RS19105	COG0254	rRNA binding
K0E66_RS19110	COG5002	protein histidine kinase activity
K0E66_RS19130	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K0E66_RS19135	COG4206	TonB-dependent receptor
K0E66_RS19135	COG1629	transport
K0E66_RS19140	COG1609	Transcriptional regulator
K0E66_RS19195	COG1554	hydrolase, family 65, central catalytic
K0E66_RS19200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K0E66_RS19225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K0E66_RS19225	COG0047	phosphoribosylformylglycinamidine synthase activity
K0E66_RS19230	COG0745	RESPONSE REGULATOR receiver
K0E66_RS19230	COG3292	Two component regulator propeller
K0E66_RS19230	COG2205	protein histidine kinase activity
K0E66_RS19245	COG1649	PFAM Uncharacterised BCR, COG1649
K0E66_RS19265	COG1966	Carbon starvation protein
K0E66_RS19270	COG1649	PFAM Uncharacterised BCR, COG1649
K0E66_RS19275	COG2205	protein histidine kinase activity
K0E66_RS19275	COG3437	response regulator, receiver
K0E66_RS19275	COG3850	Histidine kinase
K0E66_RS19275	COG4999	Histidine kinase
K0E66_RS19315	COG2113	Glycine betaine
K0E66_RS19320	COG4176	ABC-type proline glycine betaine transport system permease component
K0E66_RS19335	COG3292	Two component regulator propeller
K0E66_RS19335	COG0745	RESPONSE REGULATOR receiver
K0E66_RS19335	COG2205	protein histidine kinase activity
K0E66_RS19340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K0E66_RS19340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K0E66_RS19350	COG1621	beta-fructofuranosidase activity
K0E66_RS19395	COG0738	Major facilitator superfamily
K0E66_RS19410	COG1752	Esterase of the alpha-beta hydrolase superfamily
K0E66_RS19415	COG0475	glutathione-regulated potassium exporter activity
K0E66_RS19440	COG3015	lipoprotein NlpE involved in copper resistance
K0E66_RS19450	COG3279	Response regulator of the LytR AlgR family
K0E66_RS19475	COG4771	TonB-dependent receptor
K0E66_RS19480	COG0702	epimerase
K0E66_RS19495	COG4948	Mandelate Racemase Muconate Lactonizing
K0E66_RS19500	COG4206	TonB-dependent receptor
K0E66_RS19500	COG1629	transport
K0E66_RS19505	COG0702	epimerase
K0E66_RS19525	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K0E66_RS19545	COG0484	heat shock protein binding
K0E66_RS19550	COG0784	Response regulator, receiver
K0E66_RS19550	COG2205	protein histidine kinase activity
K0E66_RS19555	COG2194	sulfuric ester hydrolase activity
K0E66_RS19605	COG0028	Belongs to the TPP enzyme family
K0E66_RS19625	COG0459	protein refolding
K0E66_RS19630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K0E66_RS19670	COG2326	polyphosphate kinase activity
K0E66_RS19710	COG3537	Alpha-1,2-mannosidase
K0E66_RS19715	COG1506	peptidase
K0E66_RS19715	COG0823	Involved in the tonB-independent uptake of proteins
K0E66_RS19745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K0E66_RS19775	COG0514	ATP-dependent DNA helicase (RecQ)
K0E66_RS19785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K0E66_RS19795	COG0671	phosphoesterase, PA-phosphatase related
K0E66_RS19800	COG0702	epimerase
K0E66_RS19810	COG4974	Belongs to the 'phage' integrase family
K0E66_RS19860	COG0202	RNA polymerase activity
K0E66_RS19980	COG0697	spore germination
K0E66_RS19990	COG0667	Aldo Keto reductase
K0E66_RS20000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K0E66_RS20005	COG0805	protein transport
K0E66_RS20060	COG1475	DNA binding
K0E66_RS20075	COG1192	Involved in chromosome partitioning
K0E66_RS20080	COG0629	single-stranded DNA binding
K0E66_RS20110	COG3344	reverse transcriptase
K0E66_RS20130	COG3275	phosphorelay sensor kinase activity
K0E66_RS20150	COG1538	Outer membrane efflux protein
K0E66_RS20155	COG1733	regulation of RNA biosynthetic process
K0E66_RS20160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K0E66_RS20205	COG4771	TonB-dependent receptor
K0E66_RS20240	COG1196	nuclear chromosome segregation
K0E66_RS20240	COG0741	lytic transglycosylase activity
K0E66_RS20240	COG0739	heme binding
K0E66_RS20310	COG0741	lytic transglycosylase activity
K0E66_RS20310	COG0739	heme binding
K0E66_RS20310	COG1196	nuclear chromosome segregation
K0E66_RS20405	COG1132	(ABC) transporter
K0E66_RS20490	COG2755	lipolytic protein G-D-S-L family
K0E66_RS20490	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K0E66_RS20600	COG0463	Glycosyl transferase, family 2
K0E66_RS20615	COG0066	3-isopropylmalate dehydratase activity
K0E66_RS20620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K0E66_RS20625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K0E66_RS20665	COG0616	signal peptide processing
K0E66_RS20670	COG1663	tetraacyldisaccharide 4'-kinase activity
K0E66_RS20675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K0E66_RS20680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K0E66_RS20745	COG1196	nuclear chromosome segregation
K0E66_RS20755	COG1431	PFAM Stem cell self-renewal protein Piwi
K0E66_RS20770	COG4974	Belongs to the 'phage' integrase family
K0E66_RS20775	COG4974	Belongs to the 'phage' integrase family
K0E66_RS20825	COG0776	regulation of translation
K0E66_RS20890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K0E66_RS20905	COG1917	Cupin 2, conserved barrel domain protein
K0E66_RS20905	COG2207	Transcriptional regulator
K0E66_RS20910	COG1028	Short-chain dehydrogenase reductase Sdr
K0E66_RS20930	COG0463	Glycosyl transferase, family 2
K0E66_RS20945	COG1971	Probably functions as a manganese efflux pump
K0E66_RS20950	COG1477	protein flavinylation
K0E66_RS20960	COG0037	tRNA processing
K0E66_RS20975	COG4864	UPF0365 protein
K0E66_RS20985	COG2176	DNA-directed DNA polymerase activity
K0E66_RS20990	COG2910	NAD(P)H-binding
K0E66_RS20995	COG2198	Histidine kinase
K0E66_RS20995	COG5002	protein histidine kinase activity
K0E66_RS20995	COG0784	Response regulator, receiver
K0E66_RS21000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K0E66_RS21010	COG4974	Belongs to the 'phage' integrase family
K0E66_RS21035	COG1910	domain protein
K0E66_RS21090	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K0E66_RS21145	COG1028	Short-chain dehydrogenase reductase Sdr
K0E66_RS21160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K0E66_RS21165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K0E66_RS21170	COG4651	solute:proton antiporter activity
K0E66_RS21170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K0E66_RS21175	COG0439	Biotin carboxylase
K0E66_RS21180	COG0511	ligase activity, forming carbon-carbon bonds
K0E66_RS21185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K0E66_RS21190	COG1917	Cupin 2, conserved barrel domain protein
K0E66_RS21190	COG4977	sequence-specific DNA binding
K0E66_RS21200	COG1335	isochorismatase
K0E66_RS21210	COG0784	Response regulator, receiver
K0E66_RS21210	COG2205	protein histidine kinase activity
K0E66_RS21210	COG5002	protein histidine kinase activity
K0E66_RS21215	COG2207	Transcriptional regulator
K0E66_RS21220	COG0516	GMP reductase activity
K0E66_RS21220	COG0517	IMP dehydrogenase activity
K0E66_RS21250	COG2873	o-acetylhomoserine
K0E66_RS21285	COG0110	maltose O-acetyltransferase activity
K0E66_RS21300	COG2076	Multidrug Resistance protein
K0E66_RS21340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K0E66_RS21350	COG0741	lytic transglycosylase activity
K0E66_RS21350	COG1388	LysM domain
K0E66_RS21355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K0E66_RS21360	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K0E66_RS21360	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K0E66_RS21370	COG1285	pathogenesis
K0E66_RS21390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K0E66_RS21390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K0E66_RS21405	COG1115	amino acid carrier protein
K0E66_RS21415	COG1509	lysine 2,3-aminomutase activity
K0E66_RS21420	COG2233	PERMEase
K0E66_RS21435	COG1393	Belongs to the ArsC family
K0E66_RS21445	COG1629	transport
K0E66_RS21455	COG2304	oxidoreductase activity
K0E66_RS21465	COG0351	phosphomethylpyrimidine kinase
K0E66_RS21475	COG1139	Iron-sulfur cluster binding protein
K0E66_RS21480	COG0247	lactate metabolic process
K0E66_RS21485	COG0602	queuosine metabolic process
K0E66_RS21495	COG2832	Protein of unknown function (DUF454)
K0E66_RS21500	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K0E66_RS21515	COG3142	Participates in the control of copper homeostasis
K0E66_RS21520	COG1418	mRNA catabolic process
K0E66_RS21545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K0E66_RS21560	COG4771	TonB-dependent receptor
K0E66_RS21595	COG3340	Belongs to the peptidase S51 family
K0E66_RS21600	COG2378	regulation of single-species biofilm formation
K0E66_RS21650	COG1505	serine-type exopeptidase activity
K0E66_RS21675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K0E66_RS21675	COG0617	tRNA 3'-terminal CCA addition
K0E66_RS21675	COG0517	IMP dehydrogenase activity
K0E66_RS21685	COG1126	abc transporter atp-binding protein
K0E66_RS21695	COG1278	Cold shock
K0E66_RS21710	COG0438	transferase activity, transferring glycosyl groups
K0E66_RS21720	COG1215	transferase activity, transferring glycosyl groups
K0E66_RS21725	COG1216	Glycosyl transferase, family 2
K0E66_RS21745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K0E66_RS21760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K0E66_RS21770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K0E66_RS21800	COG0776	regulation of translation
K0E66_RS21810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K0E66_RS21845	COG0632	four-way junction helicase activity
K0E66_RS21850	COG0673	inositol 2-dehydrogenase activity
K0E66_RS21855	COG1272	protein, Hemolysin III
K0E66_RS21860	COG1328	CTP reductase activity
K0E66_RS21870	COG2814	Major facilitator Superfamily
K0E66_RS21880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K0E66_RS21890	COG0750	zinc metalloprotease
K0E66_RS21895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K0E66_RS21905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K0E66_RS21910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K0E66_RS21920	COG1214	PFAM Peptidase M22, glycoprotease
K0E66_RS21925	COG0784	Response regulator, receiver
K0E66_RS21925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K0E66_RS21925	COG2198	Histidine kinase
K0E66_RS21925	COG2205	protein histidine kinase activity
K0E66_RS21940	COG0194	GDP metabolic process
K0E66_RS21945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K0E66_RS21950	COG1408	metallophosphoesterase
K0E66_RS21955	COG1575	Belongs to the MenA family. Type 1 subfamily
K0E66_RS21960	COG1088	dTDP-glucose 4,6-dehydratase activity
K0E66_RS21965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K0E66_RS21975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K0E66_RS21985	COG2204	response regulator
K0E66_RS21990	COG0488	(ABC) transporter
K0E66_RS22050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K0E66_RS22055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K0E66_RS22065	COG1522	sequence-specific DNA binding
K0E66_RS22090	COG0811	peptide transport
K0E66_RS22100	COG0084	hydrolase, TatD family'
K0E66_RS22115	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K0E66_RS22120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K0E66_RS22125	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K0E66_RS22130	COG0205	6-phosphofructokinase activity
K0E66_RS22150	COG0372	Belongs to the citrate synthase family
K0E66_RS22155	COG0538	isocitrate dehydrogenase activity
K0E66_RS22165	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K0E66_RS22175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K0E66_RS22200	COG0129	dihydroxy-acid dehydratase activity
K0E66_RS22220	COG2885	chlorophyll binding
K0E66_RS22240	COG3681	Belongs to the UPF0597 family
K0E66_RS22275	COG3119	arylsulfatase activity
K0E66_RS22285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K0E66_RS22295	COG0702	epimerase
K0E66_RS22300	COG4771	TonB-dependent receptor
K0E66_RS22315	COG0702	epimerase
K0E66_RS22320	COG1629	transport
K0E66_RS22320	COG4206	TonB-dependent receptor
K0E66_RS22335	COG4771	TonB-dependent receptor
K0E66_RS22365	COG1012	belongs to the aldehyde dehydrogenase family
K0E66_RS22385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K0E66_RS22385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K0E66_RS22390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K0E66_RS22420	COG1752	Esterase of the alpha-beta hydrolase superfamily
K0E66_RS22430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K0E66_RS22435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K0E66_RS22440	COG0166	Belongs to the GPI family
K0E66_RS22640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K0E66_RS22640	COG2198	Histidine kinase
K0E66_RS22640	COG2205	protein histidine kinase activity
K0E66_RS22640	COG0784	Response regulator, receiver
K0E66_RS22655	COG3344	reverse transcriptase
K0E66_RS22670	COG0551	DNA topoisomerase type I activity
K0E66_RS22670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K0E66_RS22705	COG4974	Belongs to the 'phage' integrase family
K0E66_RS22710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K0E66_RS22875	COG0863	Belongs to the N(4) N(6)-methyltransferase family
K0E66_RS22975	COG2502	aspartate--ammonia ligase
K0E66_RS22980	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K0E66_RS22995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K0E66_RS23020	COG0860	N-Acetylmuramoyl-L-alanine amidase