locus-tag	class	description
AE940_RS00070	COG4771	TonB-dependent receptor
AE940_RS00090	COG3250	beta-galactosidase activity
AE940_RS00095	COG3250	beta-galactosidase activity
AE940_RS00105	COG3250	beta-galactosidase activity
AE940_RS00115	COG4771	TonB-dependent receptor
AE940_RS00160	COG4771	TonB-dependent receptor
AE940_RS00175	COG0628	permease
AE940_RS00190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AE940_RS00205	COG2095	MarC family integral membrane protein
AE940_RS00215	COG1629	transport
AE940_RS00220	COG4974	Belongs to the 'phage' integrase family
AE940_RS00225	COG1629	transport
AE940_RS00235	COG1629	transport
AE940_RS00235	COG4206	TonB-dependent receptor
AE940_RS00245	COG4771	TonB-dependent receptor
AE940_RS00250	COG0702	epimerase
AE940_RS00255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AE940_RS00270	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AE940_RS00270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AE940_RS00285	COG0531	amino acid
AE940_RS00295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AE940_RS00300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AE940_RS00315	COG1162	GTPase activity
AE940_RS00320	COG0233	cytoplasmic translational termination
AE940_RS00340	COG0443	Heat shock 70 kDa protein
AE940_RS00355	COG0528	UMP kinase activity
AE940_RS00360	COG0534	Mate efflux family protein
AE940_RS00395	COG0792	nuclease activity
AE940_RS00415	COG1183	phosphatidylcholine synthase activity
AE940_RS00420	COG0688	phosphatidylethanolamine metabolic process
AE940_RS00430	COG3118	belongs to the thioredoxin family
AE940_RS00465	COG0714	Associated with various cellular activities
AE940_RS00480	COG0802	atpase or kinase
AE940_RS00485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AE940_RS00495	COG2234	aminopeptidase activity
AE940_RS00515	COG1629	transport
AE940_RS00535	COG3250	beta-galactosidase activity
AE940_RS00540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AE940_RS00550	COG2205	protein histidine kinase activity
AE940_RS00550	COG0784	Response regulator, receiver
AE940_RS00575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AE940_RS00590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AE940_RS00595	COG0742	ribosomal rna small subunit methyltransferase
AE940_RS00620	COG4771	TonB-dependent receptor
AE940_RS00630	COG3537	Alpha-1,2-mannosidase
AE940_RS00645	COG3537	Alpha-1,2-mannosidase
AE940_RS00650	COG2814	Major facilitator Superfamily
AE940_RS00660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AE940_RS00665	COG0739	heme binding
AE940_RS00675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AE940_RS00680	COG1388	LysM domain
AE940_RS00680	COG3942	CHAP domain
AE940_RS00690	COG1475	DNA binding
AE940_RS00695	COG1192	Involved in chromosome partitioning
AE940_RS00700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AE940_RS00705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AE940_RS00715	COG4589	Belongs to the CDS family
AE940_RS00720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AE940_RS00725	COG0799	negative regulation of ribosome biogenesis
AE940_RS00740	COG2239	Acts as a magnesium transporter
AE940_RS00745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AE940_RS00755	COG2195	Cleaves the N-terminal amino acid of tripeptides
AE940_RS00810	COG0668	transmembrane transport
AE940_RS00815	COG2207	Transcriptional regulator
AE940_RS00815	COG0662	Cupin 2, conserved barrel domain protein
AE940_RS00860	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AE940_RS00885	COG2244	polysaccharide biosynthetic process
AE940_RS00900	COG0438	transferase activity, transferring glycosyl groups
AE940_RS00900	COG4641	Protein conserved in bacteria
AE940_RS00925	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS00930	COG3475	LICD family
AE940_RS00940	COG0438	transferase activity, transferring glycosyl groups
AE940_RS00950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AE940_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS00970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AE940_RS00975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AE940_RS00990	COG0667	Aldo Keto reductase
AE940_RS00995	COG1472	Belongs to the glycosyl hydrolase 3 family
AE940_RS01000	COG4771	TonB-dependent receptor
AE940_RS01005	COG0702	epimerase
AE940_RS01045	COG5012	cobalamin binding
AE940_RS01060	COG4124	Belongs to the glycosyl hydrolase 26 family
AE940_RS01065	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AE940_RS01070	COG2211	Major facilitator Superfamily
AE940_RS01075	COG2942	2-epimerase
AE940_RS01115	COG2205	protein histidine kinase activity
AE940_RS01115	COG2202	Pas domain
AE940_RS01125	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AE940_RS01130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AE940_RS01135	COG0713	ATP synthesis coupled electron transport
AE940_RS01140	COG0839	Belongs to the complex I subunit 6 family
AE940_RS01150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AE940_RS01155	COG0649	NAD binding
AE940_RS01155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AE940_RS01160	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AE940_RS01165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AE940_RS01175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AE940_RS01180	COG0569	domain protein
AE940_RS01185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AE940_RS01190	COG1073	alpha beta
AE940_RS01205	COG3119	arylsulfatase activity
AE940_RS01220	COG3119	arylsulfatase activity
AE940_RS01230	COG4771	TonB-dependent receptor
AE940_RS01235	COG3292	Two component regulator propeller
AE940_RS01235	COG0745	RESPONSE REGULATOR receiver
AE940_RS01235	COG2205	protein histidine kinase activity
AE940_RS01240	COG2271	Major facilitator Superfamily
AE940_RS01265	COG0805	protein transport
AE940_RS01270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AE940_RS01275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AE940_RS01300	COG4585	Histidine kinase
AE940_RS01320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AE940_RS01325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AE940_RS01325	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AE940_RS01330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AE940_RS01335	COG1078	dGTPase activity
AE940_RS01340	COG0284	orotidine-5'-phosphate decarboxylase activity
AE940_RS01345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AE940_RS01350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AE940_RS01355	COG1704	LemA family
AE940_RS01370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AE940_RS01375	COG2226	methyltransferase
AE940_RS01380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AE940_RS01385	COG1702	phosphate starvation-inducible protein PhoH
AE940_RS01395	COG2268	Band 7 protein
AE940_RS01405	COG5434	Belongs to the glycosyl hydrolase 28 family
AE940_RS01435	COG3250	beta-galactosidase activity
AE940_RS01440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AE940_RS01460	COG0457	Tetratricopeptide repeat
AE940_RS01465	COG2814	Major facilitator Superfamily
AE940_RS01490	COG0561	phosphatase activity
AE940_RS01495	COG1629	transport
AE940_RS01495	COG4206	TonB-dependent receptor
AE940_RS01505	COG4771	TonB-dependent receptor
AE940_RS01515	COG4206	TonB-dependent receptor
AE940_RS01515	COG1629	transport
AE940_RS01530	COG4206	TonB-dependent receptor
AE940_RS01530	COG1629	transport
AE940_RS01535	COG0702	epimerase
AE940_RS01540	COG0673	inositol 2-dehydrogenase activity
AE940_RS01580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AE940_RS01585	COG0793	Belongs to the peptidase S41A family
AE940_RS01590	COG2131	deaminase
AE940_RS01600	COG0339	signal peptide processing
AE940_RS01610	COG1970	mechanosensitive ion channel activity
AE940_RS01615	COG0519	Catalyzes the synthesis of GMP from XMP
AE940_RS01615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AE940_RS01625	COG4206	TonB-dependent receptor
AE940_RS01625	COG1629	transport
AE940_RS01635	COG4206	TonB-dependent receptor
AE940_RS01635	COG1629	transport
AE940_RS01640	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AE940_RS01680	COG1242	4 iron, 4 sulfur cluster binding
AE940_RS01690	COG0363	glucosamine-6-phosphate deaminase activity
AE940_RS01700	COG0009	L-threonylcarbamoyladenylate synthase
AE940_RS01710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AE940_RS01715	COG0561	phosphatase activity
AE940_RS01720	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AE940_RS01725	COG2873	o-acetylhomoserine
AE940_RS01780	COG0297	glycogen (starch) synthase activity
AE940_RS01785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AE940_RS01790	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AE940_RS01795	COG0543	2 iron, 2 sulfur cluster binding
AE940_RS01805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AE940_RS01810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AE940_RS01815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AE940_RS01825	COG0546	phosphoglycolate phosphatase activity
AE940_RS01830	COG0791	NLP P60 protein
AE940_RS01845	COG0612	Peptidase, M16
AE940_RS01850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AE940_RS01855	COG1597	lipid kinase activity
AE940_RS01860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AE940_RS01870	COG1136	(ABC) transporter
AE940_RS01890	COG2211	Major facilitator Superfamily
AE940_RS01900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AE940_RS01915	COG1674	ftsk spoiiie
AE940_RS01925	COG0492	ferredoxin-NADP+ reductase activity
AE940_RS01930	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS01960	COG1234	tRNA 3'-trailer cleavage
AE940_RS01965	COG1595	DNA-templated transcription, initiation
AE940_RS01980	COG3956	TIGRFAM MazG family protein
AE940_RS01990	COG0525	valine-tRNA ligase activity
AE940_RS01995	COG0784	Response regulator, receiver
AE940_RS01995	COG2198	Histidine kinase
AE940_RS01995	COG2205	protein histidine kinase activity
AE940_RS02015	COG4771	TonB-dependent receptor
AE940_RS02030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AE940_RS02045	COG4771	TonB-dependent receptor
AE940_RS02050	COG0702	epimerase
AE940_RS02055	COG3119	arylsulfatase activity
AE940_RS02060	COG3119	arylsulfatase activity
AE940_RS02075	COG0653	protein targeting
AE940_RS02080	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
AE940_RS02090	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AE940_RS02110	COG1253	flavin adenine dinucleotide binding
AE940_RS02120	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AE940_RS02130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AE940_RS02170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AE940_RS02180	COG2226	methyltransferase
AE940_RS02205	COG1086	Polysaccharide biosynthesis protein
AE940_RS02210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AE940_RS02215	COG1083	cytidylyl-transferase
AE940_RS02220	COG3980	spore coat polysaccharide biosynthesis protein
AE940_RS02230	COG1181	Belongs to the D-alanine--D-alanine ligase family
AE940_RS02235	COG2089	acid synthase
AE940_RS02250	COG3475	LICD family
AE940_RS02255	COG0438	transferase activity, transferring glycosyl groups
AE940_RS02270	COG0463	Glycosyl transferase, family 2
AE940_RS02270	COG1216	Glycosyl transferase, family 2
AE940_RS02275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS02280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AE940_RS02295	COG4771	TonB-dependent receptor
AE940_RS02300	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AE940_RS02305	COG0563	adenylate kinase activity
AE940_RS02310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AE940_RS02315	COG1496	oxidoreductase activity
AE940_RS02335	COG2706	6-phosphogluconolactonase activity
AE940_RS02370	COG1288	antiporter activity
AE940_RS02390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AE940_RS02410	COG0564	pseudouridine synthase activity
AE940_RS02425	COG1501	Belongs to the glycosyl hydrolase 31 family
AE940_RS02430	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS02495	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AE940_RS02570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AE940_RS02590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AE940_RS02595	COG2205	protein histidine kinase activity
AE940_RS02595	COG0784	Response regulator, receiver
AE940_RS02605	COG2176	DNA-directed DNA polymerase activity
AE940_RS02615	COG4864	UPF0365 protein
AE940_RS02630	COG0037	tRNA processing
AE940_RS02640	COG1477	protein flavinylation
AE940_RS02645	COG1971	Probably functions as a manganese efflux pump
AE940_RS02660	COG0463	Glycosyl transferase, family 2
AE940_RS02675	COG0148	phosphopyruvate hydratase activity
AE940_RS02685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AE940_RS02690	COG1082	Xylose isomerase domain protein TIM barrel
AE940_RS02710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AE940_RS02715	COG0193	aminoacyl-tRNA hydrolase activity
AE940_RS02720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AE940_RS02730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AE940_RS02735	COG1862	Preprotein translocase
AE940_RS02760	COG0542	response to heat
AE940_RS02770	COG0583	DNA-binding transcription factor activity
AE940_RS02775	COG2855	membrane
AE940_RS02790	COG1595	DNA-templated transcription, initiation
AE940_RS02805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AE940_RS02825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AE940_RS02845	COG0443	Heat shock 70 kDa protein
AE940_RS02855	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AE940_RS02860	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AE940_RS02865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AE940_RS02880	COG1501	Belongs to the glycosyl hydrolase 31 family
AE940_RS02905	COG4206	TonB-dependent receptor
AE940_RS02905	COG1629	transport
AE940_RS02915	COG1408	metallophosphoesterase
AE940_RS02920	COG1368	sulfuric ester hydrolase activity
AE940_RS02930	COG3634	alkyl hydroperoxide reductase activity
AE940_RS02960	COG1760	l-serine dehydratase
AE940_RS02965	COG0598	Magnesium transport protein CorA
AE940_RS02970	COG1193	negative regulation of DNA recombination
AE940_RS02995	COG1063	alcohol dehydrogenase
AE940_RS03010	COG3119	arylsulfatase activity
AE940_RS03015	COG5002	protein histidine kinase activity
AE940_RS03020	COG2855	membrane
AE940_RS03025	COG2217	Heavy metal translocating P-type atpase
AE940_RS03035	COG2885	chlorophyll binding
AE940_RS03040	COG3189	MarR family transcriptional regulator
AE940_RS03045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AE940_RS03050	COG2195	Cleaves the N-terminal amino acid of tripeptides
AE940_RS03055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AE940_RS03075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AE940_RS03075	COG4651	solute:proton antiporter activity
AE940_RS03080	COG1280	lysine exporter protein (LysE YggA)
AE940_RS03095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AE940_RS03100	COG0561	phosphatase activity
AE940_RS03105	COG1169	isochorismate synthase
AE940_RS03110	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AE940_RS03120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AE940_RS03125	COG4948	Mandelate Racemase Muconate Lactonizing
AE940_RS03140	COG1082	Xylose isomerase domain protein TIM barrel
AE940_RS03155	COG4771	TonB-dependent receptor
AE940_RS03185	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AE940_RS03190	COG0783	Belongs to the Dps family
AE940_RS03195	COG0583	DNA-binding transcription factor activity
AE940_RS03215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AE940_RS03255	COG1253	flavin adenine dinucleotide binding
AE940_RS03260	COG0501	Belongs to the peptidase M48B family
AE940_RS03285	COG2873	o-acetylhomoserine
AE940_RS03290	COG0482	sulfurtransferase activity
AE940_RS03295	COG2197	response regulator
AE940_RS03305	COG1757	Na H antiporter
AE940_RS03320	COG2814	Major facilitator Superfamily
AE940_RS03325	COG4953	penicillin-binding protein 1C
AE940_RS03330	COG2373	Large extracellular alpha-helical protein
AE940_RS03340	COG1918	ferrous iron import across plasma membrane
AE940_RS03340	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AE940_RS03400	COG1086	Polysaccharide biosynthesis protein
AE940_RS03405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AE940_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS03430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AE940_RS03460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AE940_RS03465	COG0463	Glycosyl transferase, family 2
AE940_RS03465	COG1216	Glycosyl transferase, family 2
AE940_RS03475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AE940_RS03480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AE940_RS03490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AE940_RS03495	COG0471	metal ion transport
AE940_RS03495	COG0490	domain, Protein
AE940_RS03510	COG0346	lactoylglutathione lyase activity
AE940_RS03525	COG0259	pyridoxamine-phosphate oxidase activity
AE940_RS03530	COG1741	Belongs to the pirin family
AE940_RS03550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AE940_RS03580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AE940_RS03590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AE940_RS03605	COG1595	DNA-templated transcription, initiation
AE940_RS03630	COG0686	Belongs to the AlaDH PNT family
AE940_RS03645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AE940_RS03660	COG1629	transport
AE940_RS03675	COG3345	alpha-galactosidase
AE940_RS03690	COG0488	(ABC) transporter
AE940_RS03695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AE940_RS03700	COG3059	membrane
AE940_RS03705	COG2207	Transcriptional regulator
AE940_RS03705	COG1917	Cupin 2, conserved barrel domain protein
AE940_RS03710	COG0295	cytidine deaminase activity
AE940_RS03715	COG1388	LysM domain
AE940_RS03715	COG1705	Flagellar rod assembly protein muramidase FlgJ
AE940_RS03730	COG0577	efflux transmembrane transporter activity
AE940_RS03735	COG0577	efflux transmembrane transporter activity
AE940_RS03740	COG0577	efflux transmembrane transporter activity
AE940_RS03750	COG0577	efflux transmembrane transporter activity
AE940_RS03750	COG1136	(ABC) transporter
AE940_RS03765	COG1136	(ABC) transporter
AE940_RS03780	COG1136	(ABC) transporter
AE940_RS03800	COG0784	Response regulator, receiver
AE940_RS03800	COG2205	protein histidine kinase activity
AE940_RS03810	COG2204	response regulator
AE940_RS03865	COG0732	type I restriction modification DNA specificity domain
AE940_RS03870	COG0732	type I restriction modification DNA specificity domain
AE940_RS03875	COG4974	Belongs to the 'phage' integrase family
AE940_RS03940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS03945	COG2244	polysaccharide biosynthetic process
AE940_RS03955	COG1216	Glycosyl transferase, family 2
AE940_RS03955	COG1442	glycosyl transferase family 8
AE940_RS03980	COG0463	Glycosyl transferase, family 2
AE940_RS03990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS03995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AE940_RS04000	COG1530	ribonuclease E activity
AE940_RS04015	COG3119	arylsulfatase activity
AE940_RS04020	COG0629	single-stranded DNA binding
AE940_RS04080	COG4206	TonB-dependent receptor
AE940_RS04095	COG5002	protein histidine kinase activity
AE940_RS04100	COG0745	RESPONSE REGULATOR receiver
AE940_RS04125	COG0488	(ABC) transporter
AE940_RS04140	COG5492	domain, Protein
AE940_RS04150	COG0436	Aminotransferase
AE940_RS04155	COG4591	ABC-type transport system involved in lipoprotein release permease component
AE940_RS04160	COG1215	transferase activity, transferring glycosyl groups
AE940_RS04165	COG0628	permease
AE940_RS04170	COG3852	Histidine kinase
AE940_RS04185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AE940_RS04190	COG1136	(ABC) transporter
AE940_RS04190	COG0577	efflux transmembrane transporter activity
AE940_RS04195	COG0577	efflux transmembrane transporter activity
AE940_RS04200	COG1252	NADH dehydrogenase
AE940_RS04230	COG4771	TonB-dependent receptor
AE940_RS04240	COG1620	l-lactate permease
AE940_RS04245	COG2885	chlorophyll binding
AE940_RS04245	COG3047	cAMP biosynthetic process
AE940_RS04255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AE940_RS04260	COG0439	Biotin carboxylase
AE940_RS04265	COG0511	ligase activity, forming carbon-carbon bonds
AE940_RS04270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AE940_RS04300	COG0508	dehydrogenase complex catalyzes the overall conversion of
AE940_RS04305	COG0022	dehydrogenase e1 component
AE940_RS04310	COG0716	FMN binding
AE940_RS04315	COG2264	protein methyltransferase activity
AE940_RS04350	COG0590	tRNA wobble adenosine to inosine editing
AE940_RS04375	COG0673	inositol 2-dehydrogenase activity
AE940_RS04380	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AE940_RS04415	COG0698	ribose 5-phosphate isomerase
AE940_RS04420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AE940_RS04425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AE940_RS04440	COG1482	cell wall glycoprotein biosynthetic process
AE940_RS04460	COG0513	Belongs to the DEAD box helicase family
AE940_RS04465	COG4221	oxidoreductase activity
AE940_RS04480	COG3250	beta-galactosidase activity
AE940_RS04490	COG0471	metal ion transport
AE940_RS04490	COG3273	potassium ion transport
AE940_RS04495	COG0529	Catalyzes the synthesis of activated sulfate
AE940_RS04500	COG0175	sulfate reduction
AE940_RS04545	COG4974	Belongs to the 'phage' integrase family
AE940_RS04570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AE940_RS04575	COG0242	peptide deformylase activity
AE940_RS04590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AE940_RS04595	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AE940_RS04600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AE940_RS04605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AE940_RS04615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AE940_RS04620	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AE940_RS04635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AE940_RS04680	COG1940	carbohydrate kinase activity
AE940_RS04685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AE940_RS04695	COG2271	Major facilitator Superfamily
AE940_RS04700	COG2731	YhcH YjgK YiaL family protein
AE940_RS04705	COG4206	TonB-dependent receptor
AE940_RS04705	COG1629	transport
AE940_RS04710	COG0702	epimerase
AE940_RS04725	COG1629	transport
AE940_RS04730	COG0702	epimerase
AE940_RS04745	COG4771	TonB-dependent receptor
AE940_RS04750	COG0702	epimerase
AE940_RS04755	COG0702	epimerase
AE940_RS04760	COG4206	TonB-dependent receptor
AE940_RS04760	COG1629	transport
AE940_RS04765	COG1629	transport
AE940_RS04765	COG4206	TonB-dependent receptor
AE940_RS04780	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS04800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS04810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS04815	COG3537	Alpha-1,2-mannosidase
AE940_RS04820	COG3250	beta-galactosidase activity
AE940_RS04825	COG1629	transport
AE940_RS04825	COG4206	TonB-dependent receptor
AE940_RS04830	COG0702	epimerase
AE940_RS04835	COG3250	beta-galactosidase activity
AE940_RS04840	COG0484	heat shock protein binding
AE940_RS04845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AE940_RS04850	COG0488	(ABC) transporter
AE940_RS04855	COG1595	DNA-templated transcription, initiation
AE940_RS04970	COG2885	chlorophyll binding
AE940_RS05085	COG2183	response to ionizing radiation
AE940_RS05090	COG2205	protein histidine kinase activity
AE940_RS05095	COG0737	Belongs to the 5'-nucleotidase family
AE940_RS05100	COG1956	GAF domain-containing protein
AE940_RS05110	COG4771	TonB-dependent receptor
AE940_RS05325	COG0863	Belongs to the N(4) N(6)-methyltransferase family
AE940_RS05375	COG0534	Mate efflux family protein
AE940_RS05385	COG0534	Mate efflux family protein
AE940_RS05395	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AE940_RS05405	COG0318	PFAM AMP-dependent synthetase and ligase
AE940_RS05410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS05415	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AE940_RS05455	COG4750	Nucleotidyl transferase
AE940_RS05470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AE940_RS05475	COG3475	LICD family
AE940_RS05495	COG2244	polysaccharide biosynthetic process
AE940_RS05515	COG0438	transferase activity, transferring glycosyl groups
AE940_RS05525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS05530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AE940_RS05550	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AE940_RS05555	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AE940_RS05560	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AE940_RS05565	COG0363	glucosamine-6-phosphate deaminase activity
AE940_RS05585	COG4413	Urea transporter
AE940_RS05615	COG3279	Response regulator of the LytR AlgR family
AE940_RS05625	COG0577	efflux transmembrane transporter activity
AE940_RS05625	COG1136	(ABC) transporter
AE940_RS05630	COG1136	(ABC) transporter
AE940_RS05635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AE940_RS05660	COG4884	unkown
AE940_RS05660	COG3831	ATPase activity
AE940_RS05675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AE940_RS05685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AE940_RS05690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AE940_RS05695	COG3250	beta-galactosidase activity
AE940_RS05720	COG0501	Belongs to the peptidase M48B family
AE940_RS05725	COG1704	LemA family
AE940_RS05730	COG1595	DNA-templated transcription, initiation
AE940_RS05740	COG4206	TonB-dependent receptor
AE940_RS05740	COG1629	transport
AE940_RS05750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AE940_RS05755	COG2885	chlorophyll binding
AE940_RS05755	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AE940_RS05765	COG0697	spore germination
AE940_RS05795	COG0776	regulation of translation
AE940_RS05855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AE940_RS05870	COG1846	Transcriptional regulator
AE940_RS05870	COG0456	acetyltransferase
AE940_RS05875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AE940_RS05880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AE940_RS05885	COG2814	Major facilitator Superfamily
AE940_RS05890	COG4771	TonB-dependent receptor
AE940_RS05920	COG4771	TonB-dependent receptor
AE940_RS06075	COG0542	response to heat
AE940_RS06100	COG0156	8-amino-7-oxononanoate synthase activity
AE940_RS06125	COG0488	(ABC) transporter
AE940_RS06145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AE940_RS06145	COG2205	protein histidine kinase activity
AE940_RS06145	COG0784	Response regulator, receiver
AE940_RS06145	COG2198	Histidine kinase
AE940_RS06165	COG0438	transferase activity, transferring glycosyl groups
AE940_RS06180	COG2244	polysaccharide biosynthetic process
AE940_RS06185	COG0438	transferase activity, transferring glycosyl groups
AE940_RS06195	COG1215	transferase activity, transferring glycosyl groups
AE940_RS06225	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AE940_RS06230	COG1805	sodium ion transport
AE940_RS06235	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AE940_RS06260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AE940_RS06265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AE940_RS06275	COG0545	Peptidyl-prolyl cis-trans isomerase
AE940_RS06280	COG1739	Uncharacterized protein family UPF0029
AE940_RS06290	COG0778	Nitroreductase
AE940_RS06295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AE940_RS06295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AE940_RS06300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AE940_RS06330	COG2217	Heavy metal translocating P-type atpase
AE940_RS06340	COG0321	lipoyl(octanoyl) transferase activity
AE940_RS06370	COG3852	Histidine kinase
AE940_RS06375	COG2204	response regulator
AE940_RS06395	COG1136	(ABC) transporter
AE940_RS06410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AE940_RS06415	COG1755	Isoprenylcysteine carboxyl methyltransferase
AE940_RS06430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AE940_RS06445	COG1678	Uncharacterized ACR, COG1678
AE940_RS06460	COG0667	Aldo Keto reductase
AE940_RS06470	COG0656	L-ascorbic acid biosynthetic process
AE940_RS06480	COG0656	L-ascorbic acid biosynthetic process
AE940_RS06485	COG0656	L-ascorbic acid biosynthetic process
AE940_RS06500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AE940_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS06535	COG1979	alcohol dehydrogenase
AE940_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS06560	COG0667	Aldo Keto reductase
AE940_RS06575	COG2311	Membrane
AE940_RS06580	COG0667	Aldo Keto reductase
AE940_RS06645	COG4771	TonB-dependent receptor
AE940_RS06670	COG1309	transcriptional regulator
AE940_RS06685	COG1132	(ABC) transporter
AE940_RS06690	COG2205	protein histidine kinase activity
AE940_RS06705	COG1522	sequence-specific DNA binding
AE940_RS06725	COG3969	phosphoadenosine phosphosulfate
AE940_RS06730	COG1475	DNA binding
AE940_RS06770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS06775	COG0745	RESPONSE REGULATOR receiver
AE940_RS06790	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS06800	COG4206	TonB-dependent receptor
AE940_RS06800	COG1629	transport
AE940_RS06810	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AE940_RS06830	COG1022	Amp-dependent synthetase and ligase
AE940_RS06835	COG3263	regulation of cellular component size
AE940_RS06845	COG1151	hydroxylamine reductase activity
AE940_RS06880	COG1136	(ABC) transporter
AE940_RS06880	COG0577	efflux transmembrane transporter activity
AE940_RS06890	COG0577	efflux transmembrane transporter activity
AE940_RS06890	COG1136	(ABC) transporter
AE940_RS06905	COG0534	Mate efflux family protein
AE940_RS06910	COG1011	Hydrolase
AE940_RS06915	COG0167	dihydroorotate dehydrogenase activity
AE940_RS06925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AE940_RS06940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AE940_RS06955	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AE940_RS06965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AE940_RS06975	COG0356	it plays a direct role in the translocation of protons across the membrane
AE940_RS06980	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AE940_RS06985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AE940_RS06990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AE940_RS06995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AE940_RS07000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AE940_RS07005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AE940_RS07010	COG3118	belongs to the thioredoxin family
AE940_RS07030	COG0745	RESPONSE REGULATOR receiver
AE940_RS07035	COG5002	protein histidine kinase activity
AE940_RS07065	COG1120	ATPase activity
AE940_RS07070	COG1091	dTDP-4-dehydrorhamnose reductase activity
AE940_RS07100	COG2205	protein histidine kinase activity
AE940_RS07105	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AE940_RS07115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AE940_RS07130	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AE940_RS07135	COG0540	Belongs to the ATCase OTCase family
AE940_RS07145	COG2431	L-lysine efflux transmembrane transporter activity
AE940_RS07170	COG2837	iron assimilation
AE940_RS07180	COG1629	transport
AE940_RS07180	COG4206	TonB-dependent receptor
AE940_RS07200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AE940_RS07210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AE940_RS07230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AE940_RS07235	COG2205	protein histidine kinase activity
AE940_RS07445	COG0629	single-stranded DNA binding
AE940_RS07450	COG0358	DNA primase activity
AE940_RS07510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AE940_RS07515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AE940_RS07525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AE940_RS07535	COG0673	inositol 2-dehydrogenase activity
AE940_RS07545	COG2223	nitrite transmembrane transporter activity
AE940_RS07565	COG0671	phosphoesterase, PA-phosphatase related
AE940_RS07575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AE940_RS07580	COG0045	succinate-CoA ligase (ADP-forming) activity
AE940_RS07585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AE940_RS07590	COG0351	phosphomethylpyrimidine kinase
AE940_RS07600	COG1070	Carbohydrate kinase
AE940_RS07610	COG2814	Major facilitator Superfamily
AE940_RS07610	COG0477	Major facilitator Superfamily
AE940_RS07620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AE940_RS07620	COG3153	acetyltransferase
AE940_RS07625	COG0450	alkyl hydroperoxide reductase
AE940_RS07630	COG0724	RNA recognition motif
AE940_RS07635	COG1858	cytochrome C peroxidase
AE940_RS07640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AE940_RS07670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AE940_RS07685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AE940_RS07735	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AE940_RS07745	COG1904	glucuronate isomerase
AE940_RS07775	COG0513	Belongs to the DEAD box helicase family
AE940_RS07780	COG3830	Belongs to the UPF0237 family
AE940_RS07780	COG0560	Phosphoserine phosphatase
AE940_RS07795	COG0343	queuine tRNA-ribosyltransferase activity
AE940_RS07800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AE940_RS07805	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AE940_RS07830	COG2205	protein histidine kinase activity
AE940_RS07835	COG2204	response regulator
AE940_RS07880	COG0577	efflux transmembrane transporter activity
AE940_RS07880	COG1136	(ABC) transporter
AE940_RS07885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AE940_RS07960	COG0156	8-amino-7-oxononanoate synthase activity
AE940_RS07965	COG1597	lipid kinase activity
AE940_RS07970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AE940_RS07995	COG0577	efflux transmembrane transporter activity
AE940_RS07995	COG1136	(ABC) transporter
AE940_RS08020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AE940_RS08050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AE940_RS08065	COG0543	2 iron, 2 sulfur cluster binding
AE940_RS08070	COG0167	dihydroorotate dehydrogenase activity
AE940_RS08075	COG0336	Belongs to the RNA methyltransferase TrmD family
AE940_RS08080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AE940_RS08085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AE940_RS08095	COG2315	Protein conserved in bacteria
AE940_RS08130	COG0542	response to heat
AE940_RS08175	COG2304	oxidoreductase activity
AE940_RS08190	COG0714	Associated with various cellular activities
AE940_RS08195	COG1652	LysM domain
AE940_RS08205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AE940_RS08210	COG0552	protein localization to endoplasmic reticulum
AE940_RS08215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AE940_RS08220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AE940_RS08230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AE940_RS08245	COG0442	prolyl-tRNA aminoacylation
AE940_RS08255	COG4946	Tricorn protease homolog
AE940_RS08255	COG0793	Belongs to the peptidase S41A family
AE940_RS08270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AE940_RS08285	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AE940_RS08295	COG1492	cobalamin metabolic process
AE940_RS08335	COG0784	Response regulator, receiver
AE940_RS08335	COG5002	protein histidine kinase activity
AE940_RS08335	COG2198	Histidine kinase
AE940_RS08340	COG2096	Adenosyltransferase
AE940_RS08345	COG1797	cobyrinic acid a,c-diamide synthase activity
AE940_RS08360	COG2966	Psort location CytoplasmicMembrane, score
AE940_RS08370	COG4771	TonB-dependent receptor
AE940_RS08380	COG4774	siderophore transport
AE940_RS08390	COG1429	ligase activity, forming nitrogen-metal bonds
AE940_RS08425	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AE940_RS08495	COG0352	thiamine-phosphate diphosphorylase activity
AE940_RS08500	COG2022	thiamine diphosphate biosynthetic process
AE940_RS08505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AE940_RS08525	COG0352	thiamine-phosphate diphosphorylase activity
AE940_RS08585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AE940_RS08585	COG0574	Belongs to the PEP-utilizing enzyme family
AE940_RS08590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AE940_RS08595	COG0564	pseudouridine synthase activity
AE940_RS08610	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AE940_RS08630	COG0024	Methionine aminopeptidase
AE940_RS08655	COG0481	GTPase activity
AE940_RS08675	COG0708	Exodeoxyribonuclease III
AE940_RS08680	COG1914	H( )-stimulated, divalent metal cation uptake system
AE940_RS08695	COG0217	transcriptional regulatory protein
AE940_RS08700	COG0072	phenylalanine-tRNA ligase activity
AE940_RS08700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AE940_RS08705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AE940_RS08710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS08715	COG0297	glycogen (starch) synthase activity
AE940_RS08720	COG0438	transferase activity, transferring glycosyl groups
AE940_RS08725	COG0438	transferase activity, transferring glycosyl groups
AE940_RS08735	COG1216	Glycosyl transferase, family 2
AE940_RS08745	COG1215	transferase activity, transferring glycosyl groups
AE940_RS08750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS08795	COG0305	Participates in initiation and elongation during chromosome replication
AE940_RS08800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AE940_RS08815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AE940_RS08820	COG4657	Part of a membrane complex involved in electron transport
AE940_RS08825	COG4660	Part of a membrane complex involved in electron transport
AE940_RS08830	COG4659	FMN binding
AE940_RS08835	COG4658	electron transport chain
AE940_RS08840	COG4656	Part of a membrane complex involved in electron transport
AE940_RS08870	COG0504	CTP synthase activity
AE940_RS08880	COG0534	Mate efflux family protein
AE940_RS08885	COG1506	peptidase
AE940_RS08885	COG0823	Involved in the tonB-independent uptake of proteins
AE940_RS08900	COG1695	Transcriptional regulator
AE940_RS08915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AE940_RS08925	COG3942	CHAP domain
AE940_RS08925	COG1388	LysM domain
AE940_RS08955	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AE940_RS08960	COG0556	nucleotide-excision repair
AE940_RS08965	COG2949	membrane
AE940_RS08975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AE940_RS08985	COG0784	Response regulator, receiver
AE940_RS08985	COG2198	Histidine kinase
AE940_RS08985	COG2205	protein histidine kinase activity
AE940_RS08995	COG0842	Transport permease protein
AE940_RS09000	COG1131	(ABC) transporter
AE940_RS09030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AE940_RS09035	COG0505	Belongs to the CarA family
AE940_RS09045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AE940_RS09050	COG0367	asparagine synthase
AE940_RS09075	COG0436	Aminotransferase
AE940_RS09085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AE940_RS09095	COG1979	alcohol dehydrogenase
AE940_RS09105	COG0133	tryptophan synthase activity
AE940_RS09110	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AE940_RS09115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AE940_RS09115	COG0512	Glutamine amidotransferase of anthranilate synthase
AE940_RS09125	COG0134	indole-3-glycerol-phosphate synthase activity
AE940_RS09130	COG0135	phosphoribosylanthranilate isomerase activity
AE940_RS09135	COG0159	tryptophan synthase activity
AE940_RS09140	COG0252	asparaginase activity
AE940_RS09155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AE940_RS09165	COG0110	maltose O-acetyltransferase activity
AE940_RS09170	COG2197	response regulator
AE940_RS09180	COG0138	bifunctional purine biosynthesis protein purh
AE940_RS09185	COG0716	FMN binding
AE940_RS09210	COG1858	cytochrome C peroxidase
AE940_RS09220	COG4771	TonB-dependent receptor
AE940_RS09230	COG2814	Major facilitator Superfamily
AE940_RS09235	COG1566	PFAM secretion protein HlyD family protein
AE940_RS09265	COG4771	TonB-dependent receptor
AE940_RS09290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AE940_RS09295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AE940_RS09305	COG2966	Psort location CytoplasmicMembrane, score
AE940_RS09310	COG3610	response to peptide
AE940_RS09325	COG1609	Transcriptional regulator
AE940_RS09335	COG1733	regulation of RNA biosynthetic process
AE940_RS09340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AE940_RS09340	COG2198	Histidine kinase
AE940_RS09340	COG2205	protein histidine kinase activity
AE940_RS09340	COG0784	Response regulator, receiver
AE940_RS09360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AE940_RS09365	COG1690	Belongs to the RtcB family
AE940_RS09385	COG0228	four-way junction DNA binding
AE940_RS09400	COG0724	RNA recognition motif
AE940_RS09410	COG1177	transmembrane transport
AE940_RS09415	COG1176	ABC-type spermidine putrescine transport system, permease component I
AE940_RS09425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AE940_RS09435	COG0058	SHG alpha-glucan phosphorylase activity
AE940_RS09445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AE940_RS09465	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AE940_RS09520	COG0745	RESPONSE REGULATOR receiver
AE940_RS09525	COG5002	protein histidine kinase activity
AE940_RS09550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AE940_RS09560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AE940_RS09570	COG4948	Mandelate Racemase Muconate Lactonizing
AE940_RS09585	COG1295	ribonuclease BN
AE940_RS09590	COG0778	Nitroreductase
AE940_RS09600	COG0704	Plays a role in the regulation of phosphate uptake
AE940_RS09605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AE940_RS09610	COG0581	inorganic phosphate transmembrane transporter activity
AE940_RS09615	COG0573	inorganic phosphate transmembrane transporter activity
AE940_RS09625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AE940_RS09645	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AE940_RS09680	COG3023	N-Acetylmuramoyl-L-alanine amidase
AE940_RS09710	COG3594	Acyltransferase
AE940_RS09745	COG1216	Glycosyl transferase, family 2
AE940_RS09765	COG1216	Glycosyl transferase, family 2
AE940_RS09780	COG0438	transferase activity, transferring glycosyl groups
AE940_RS09785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AE940_RS09795	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AE940_RS09845	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AE940_RS09875	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AE940_RS09880	COG0167	dihydroorotate dehydrogenase activity
AE940_RS09945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AE940_RS09945	COG4191	Histidine kinase
AE940_RS09960	COG2172	sigma factor antagonist activity
AE940_RS09970	COG2208	phosphoserine phosphatase activity
AE940_RS09995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AE940_RS10015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AE940_RS10020	COG0497	DNA recombination
AE940_RS10030	COG2176	DNA-directed DNA polymerase activity
AE940_RS10030	COG5002	protein histidine kinase activity
AE940_RS10035	COG0592	DNA-directed DNA polymerase activity
AE940_RS10050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AE940_RS10050	COG0321	lipoyl(octanoyl) transferase activity
AE940_RS10065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS10070	COG0156	8-amino-7-oxononanoate synthase activity
AE940_RS10155	COG0019	diaminopimelate decarboxylase activity
AE940_RS10160	COG0527	aspartate kinase activity
AE940_RS10165	COG2884	Cell division ATP-binding protein ftsE
AE940_RS10170	COG0140	phosphoribosyl-ATP diphosphatase activity
AE940_RS10170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AE940_RS10180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AE940_RS10205	COG3586	endonuclease activity
AE940_RS10240	COG1472	Belongs to the glycosyl hydrolase 3 family
AE940_RS10245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AE940_RS10255	COG5012	cobalamin binding
AE940_RS10265	COG1472	Belongs to the glycosyl hydrolase 3 family
AE940_RS10270	COG0702	epimerase
AE940_RS10275	COG4771	TonB-dependent receptor
AE940_RS10295	COG0693	protein deglycase activity
AE940_RS10300	COG0494	nUDIX hydrolase
AE940_RS10305	COG1401	restriction endodeoxyribonuclease activity
AE940_RS10320	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AE940_RS10365	COG1917	Cupin 2, conserved barrel domain protein
AE940_RS10365	COG4977	sequence-specific DNA binding
AE940_RS10370	COG2814	Major facilitator Superfamily
AE940_RS10375	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS10380	COG2207	Transcriptional regulator
AE940_RS10395	COG1090	epimerase
AE940_RS10425	COG0561	phosphatase activity
AE940_RS10430	COG1629	transport
AE940_RS10430	COG4206	TonB-dependent receptor
AE940_RS10480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AE940_RS10490	COG0363	glucosamine-6-phosphate deaminase activity
AE940_RS10530	COG1032	radical SAM domain protein
AE940_RS10535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AE940_RS10540	COG0463	Glycosyl transferase, family 2
AE940_RS10545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AE940_RS10555	COG0646	methionine synthase
AE940_RS10555	COG1410	methionine synthase
AE940_RS10610	COG1408	metallophosphoesterase
AE940_RS10615	COG1132	(ABC) transporter
AE940_RS10620	COG1132	(ABC) transporter
AE940_RS10635	COG0420	3'-5' exonuclease activity
AE940_RS10655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AE940_RS10660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AE940_RS10670	COG0681	Belongs to the peptidase S26 family
AE940_RS10755	COG0641	radical SAM
AE940_RS10760	COG3591	Belongs to the peptidase S1B family
AE940_RS10765	COG3591	Belongs to the peptidase S1B family
AE940_RS10800	COG1773	rubredoxin
AE940_RS10800	COG1592	Rubrerythrin
AE940_RS10810	COG3152	Membrane
AE940_RS10815	COG0339	signal peptide processing
AE940_RS10820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AE940_RS10820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AE940_RS10830	COG1629	transport
AE940_RS10830	COG4206	TonB-dependent receptor
AE940_RS10845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AE940_RS10845	COG0131	Imidazoleglycerol-phosphate dehydratase
AE940_RS10850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AE940_RS10855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AE940_RS10860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AE940_RS10870	COG1741	Belongs to the pirin family
AE940_RS10875	COG4232	protein-disulfide reductase activity
AE940_RS10885	COG0572	uridine kinase
AE940_RS10895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AE940_RS10905	COG0646	methionine synthase
AE940_RS10905	COG1410	methionine synthase
AE940_RS10910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AE940_RS10945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AE940_RS10955	COG1295	ribonuclease BN
AE940_RS10980	COG2205	protein histidine kinase activity
AE940_RS10980	COG2202	Pas domain
AE940_RS10985	COG0534	Mate efflux family protein
AE940_RS10990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AE940_RS11000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AE940_RS11005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AE940_RS11070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AE940_RS11110	COG2195	Cleaves the N-terminal amino acid of tripeptides
AE940_RS11120	COG0668	transmembrane transport
AE940_RS11125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AE940_RS11135	COG3250	beta-galactosidase activity
AE940_RS11140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS11145	COG3119	arylsulfatase activity
AE940_RS11150	COG3119	arylsulfatase activity
AE940_RS11155	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS11160	COG3292	Two component regulator propeller
AE940_RS11160	COG2205	protein histidine kinase activity
AE940_RS11160	COG0745	RESPONSE REGULATOR receiver
AE940_RS11165	COG1830	Aldolase
AE940_RS11170	COG0588	phosphoglycerate mutase activity
AE940_RS11180	COG1119	ATPase activity
AE940_RS11185	COG3119	arylsulfatase activity
AE940_RS11190	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS11200	COG1629	transport
AE940_RS11200	COG4206	TonB-dependent receptor
AE940_RS11210	COG1595	DNA-templated transcription, initiation
AE940_RS11215	COG1523	belongs to the glycosyl hydrolase 13 family
AE940_RS11220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AE940_RS11240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AE940_RS11250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AE940_RS11255	COG0126	phosphoglycerate kinase activity
AE940_RS11270	COG2311	Membrane
AE940_RS11315	COG0424	maF-like protein
AE940_RS11320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AE940_RS11335	COG0778	Nitroreductase
AE940_RS11340	COG0288	reversible hydration of carbon dioxide
AE940_RS11355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AE940_RS11365	COG0511	ligase activity, forming carbon-carbon bonds
AE940_RS11365	COG5016	pyruvate
AE940_RS11370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AE940_RS11385	COG0366	Alpha amylase catalytic
AE940_RS11405	COG0191	fructose-bisphosphate aldolase activity
AE940_RS11415	COG0254	rRNA binding
AE940_RS11440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AE940_RS11445	COG1629	transport
AE940_RS11445	COG4206	TonB-dependent receptor
AE940_RS11450	COG1609	Transcriptional regulator
AE940_RS11460	COG1554	hydrolase, family 65, central catalytic
AE940_RS11465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AE940_RS11485	COG0047	phosphoribosylformylglycinamidine synthase activity
AE940_RS11485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AE940_RS11490	COG0745	RESPONSE REGULATOR receiver
AE940_RS11490	COG2205	protein histidine kinase activity
AE940_RS11490	COG3292	Two component regulator propeller
AE940_RS11505	COG1649	PFAM Uncharacterised BCR, COG1649
AE940_RS11525	COG1966	Carbon starvation protein
AE940_RS11530	COG1649	PFAM Uncharacterised BCR, COG1649
AE940_RS11535	COG0784	Response regulator, receiver
AE940_RS11535	COG2205	protein histidine kinase activity
AE940_RS11565	COG2113	Glycine betaine
AE940_RS11570	COG4176	ABC-type proline glycine betaine transport system permease component
AE940_RS11585	COG3292	Two component regulator propeller
AE940_RS11585	COG2205	protein histidine kinase activity
AE940_RS11585	COG0745	RESPONSE REGULATOR receiver
AE940_RS11590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AE940_RS11590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AE940_RS11600	COG1621	beta-fructofuranosidase activity
AE940_RS11625	COG0738	Major facilitator superfamily
AE940_RS11640	COG1752	Esterase of the alpha-beta hydrolase superfamily
AE940_RS11645	COG0475	glutathione-regulated potassium exporter activity
AE940_RS11670	COG3015	lipoprotein NlpE involved in copper resistance
AE940_RS11690	COG1917	Cupin 2, conserved barrel domain protein
AE940_RS11690	COG4977	sequence-specific DNA binding
AE940_RS11715	COG4771	TonB-dependent receptor
AE940_RS11720	COG0702	epimerase
AE940_RS11735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AE940_RS11755	COG0484	heat shock protein binding
AE940_RS11760	COG0784	Response regulator, receiver
AE940_RS11760	COG2205	protein histidine kinase activity
AE940_RS11765	COG2194	sulfuric ester hydrolase activity
AE940_RS11810	COG0028	Belongs to the TPP enzyme family
AE940_RS11835	COG0459	protein refolding
AE940_RS11840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AE940_RS11880	COG2326	polyphosphate kinase activity
AE940_RS11915	COG3537	Alpha-1,2-mannosidase
AE940_RS11920	COG0823	Involved in the tonB-independent uptake of proteins
AE940_RS11920	COG1506	peptidase
AE940_RS11925	COG0124	histidyl-tRNA synthetase
AE940_RS11950	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AE940_RS11990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AE940_RS12000	COG0671	phosphoesterase, PA-phosphatase related
AE940_RS12020	COG0702	epimerase
AE940_RS12025	COG4771	TonB-dependent receptor
AE940_RS12045	COG0463	Glycosyl transferase, family 2
AE940_RS12060	COG0066	3-isopropylmalate dehydratase activity
AE940_RS12065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AE940_RS12070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AE940_RS12120	COG0616	signal peptide processing
AE940_RS12125	COG1663	tetraacyldisaccharide 4'-kinase activity
AE940_RS12130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AE940_RS12135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AE940_RS12210	COG0667	Aldo Keto reductase
AE940_RS12250	COG0546	phosphoglycolate phosphatase activity
AE940_RS12265	COG2207	Transcriptional regulator
AE940_RS12270	COG3292	Two component regulator propeller
AE940_RS12270	COG2205	protein histidine kinase activity
AE940_RS12270	COG0745	RESPONSE REGULATOR receiver
AE940_RS12275	COG4948	Mandelate Racemase Muconate Lactonizing
AE940_RS12295	COG0702	epimerase
AE940_RS12300	COG1629	transport
AE940_RS12300	COG4206	TonB-dependent receptor
AE940_RS12330	COG1917	Cupin 2, conserved barrel domain protein
AE940_RS12330	COG2207	Transcriptional regulator
AE940_RS12360	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS12425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AE940_RS12435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AE940_RS12435	COG4651	solute:proton antiporter activity
AE940_RS12440	COG0439	Biotin carboxylase
AE940_RS12445	COG5016	pyruvate
AE940_RS12445	COG0511	ligase activity, forming carbon-carbon bonds
AE940_RS12450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AE940_RS12455	COG1335	isochorismatase
AE940_RS12465	COG0516	GMP reductase activity
AE940_RS12465	COG0517	IMP dehydrogenase activity
AE940_RS12480	COG2207	Transcriptional regulator
AE940_RS12485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AE940_RS12500	COG2873	o-acetylhomoserine
AE940_RS12565	COG2217	Heavy metal translocating P-type atpase
AE940_RS12575	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AE940_RS12585	COG1388	LysM domain
AE940_RS12585	COG0741	lytic transglycosylase activity
AE940_RS12590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AE940_RS12595	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AE940_RS12595	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AE940_RS12605	COG1285	pathogenesis
AE940_RS12625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AE940_RS12625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AE940_RS12640	COG1115	amino acid carrier protein
AE940_RS12650	COG1509	lysine 2,3-aminomutase activity
AE940_RS12655	COG2233	PERMEase
AE940_RS12670	COG1393	Belongs to the ArsC family
AE940_RS12680	COG4206	TonB-dependent receptor
AE940_RS12680	COG1629	transport
AE940_RS12690	COG2304	oxidoreductase activity
AE940_RS12700	COG0351	phosphomethylpyrimidine kinase
AE940_RS12710	COG1139	Iron-sulfur cluster binding protein
AE940_RS12715	COG0247	lactate metabolic process
AE940_RS12720	COG0602	queuosine metabolic process
AE940_RS12730	COG2832	Protein of unknown function (DUF454)
AE940_RS12735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AE940_RS12750	COG3142	Participates in the control of copper homeostasis
AE940_RS12755	COG1418	mRNA catabolic process
AE940_RS12775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AE940_RS12790	COG4771	TonB-dependent receptor
AE940_RS12820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AE940_RS12930	COG0517	IMP dehydrogenase activity
AE940_RS12930	COG0617	tRNA 3'-terminal CCA addition
AE940_RS12930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AE940_RS12955	COG0612	Peptidase, M16
AE940_RS12965	COG1278	Cold shock
AE940_RS12975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AE940_RS12980	COG1216	Glycosyl transferase, family 2
AE940_RS12985	COG0438	transferase activity, transferring glycosyl groups
AE940_RS12995	COG1442	glycosyl transferase family 8
AE940_RS12995	COG1216	Glycosyl transferase, family 2
AE940_RS13010	COG2244	polysaccharide biosynthetic process
AE940_RS13030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AE940_RS13040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AE940_RS13080	COG0776	regulation of translation
AE940_RS13085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AE940_RS13115	COG0632	four-way junction helicase activity
AE940_RS13120	COG0673	inositol 2-dehydrogenase activity
AE940_RS13125	COG1272	protein, Hemolysin III
AE940_RS13130	COG1328	CTP reductase activity
AE940_RS13140	COG2814	Major facilitator Superfamily
AE940_RS13150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AE940_RS13160	COG0750	zinc metalloprotease
AE940_RS13175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AE940_RS13180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AE940_RS13190	COG1214	PFAM Peptidase M22, glycoprotease
AE940_RS13205	COG0194	GDP metabolic process
AE940_RS13210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AE940_RS13215	COG1408	metallophosphoesterase
AE940_RS13220	COG1575	Belongs to the MenA family. Type 1 subfamily
AE940_RS13225	COG1088	dTDP-glucose 4,6-dehydratase activity
AE940_RS13230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AE940_RS13240	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AE940_RS13250	COG2204	response regulator
AE940_RS13255	COG0488	(ABC) transporter
AE940_RS13320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AE940_RS13330	COG1522	sequence-specific DNA binding
AE940_RS13355	COG0811	peptide transport
AE940_RS13365	COG0084	hydrolase, TatD family'
AE940_RS13380	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AE940_RS13385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AE940_RS13390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AE940_RS13395	COG0205	6-phosphofructokinase activity
AE940_RS13415	COG0372	Belongs to the citrate synthase family
AE940_RS13420	COG0538	isocitrate dehydrogenase activity
AE940_RS13430	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AE940_RS13440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AE940_RS13465	COG0129	dihydroxy-acid dehydratase activity
AE940_RS13490	COG2885	chlorophyll binding
AE940_RS13510	COG3681	Belongs to the UPF0597 family
AE940_RS13540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AE940_RS13550	COG0702	epimerase
AE940_RS13555	COG4771	TonB-dependent receptor
AE940_RS13570	COG0702	epimerase
AE940_RS13575	COG4206	TonB-dependent receptor
AE940_RS13575	COG1629	transport
AE940_RS13580	COG3291	Pkd domain containing protein
AE940_RS13580	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS13590	COG4771	TonB-dependent receptor
AE940_RS13645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AE940_RS13645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AE940_RS13650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AE940_RS13685	COG0534	Mate efflux family protein
AE940_RS13690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AE940_RS13695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AE940_RS13700	COG0166	Belongs to the GPI family
AE940_RS13710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AE940_RS13720	COG2502	aspartate--ammonia ligase
AE940_RS13725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AE940_RS13740	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS13755	COG0860	N-Acetylmuramoyl-L-alanine amidase
AE940_RS13765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AE940_RS13780	COG1640	4-alpha-glucanotransferase
AE940_RS13790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AE940_RS13795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AE940_RS13815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AE940_RS13820	COG1022	Amp-dependent synthetase and ligase
AE940_RS13830	COG0359	binds to the 23S rRNA
AE940_RS13835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AE940_RS13840	COG0360	Binds together with S18 to 16S ribosomal RNA
AE940_RS13860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AE940_RS13870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AE940_RS13890	COG4771	TonB-dependent receptor
AE940_RS13905	COG2431	L-lysine efflux transmembrane transporter activity
AE940_RS13930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AE940_RS13935	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AE940_RS13940	COG0386	Belongs to the glutathione peroxidase family
AE940_RS13960	COG3275	phosphorelay sensor kinase activity
AE940_RS13965	COG3279	Response regulator of the LytR AlgR family
AE940_RS13985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AE940_RS14000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AE940_RS14010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AE940_RS14015	COG0658	competence protein
AE940_RS14020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AE940_RS14025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AE940_RS14035	COG0009	L-threonylcarbamoyladenylate synthase
AE940_RS14060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AE940_RS14065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AE940_RS14120	COG2244	polysaccharide biosynthetic process
AE940_RS14145	COG2818	Glycosylase
AE940_RS14150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AE940_RS14150	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AE940_RS14155	COG0514	ATP-dependent DNA helicase (RecQ)
AE940_RS14165	COG2271	Major facilitator Superfamily
AE940_RS14180	COG0702	epimerase
AE940_RS14185	COG4771	TonB-dependent receptor
AE940_RS14190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AE940_RS14195	COG2186	Transcriptional regulator
AE940_RS14205	COG0436	Aminotransferase
AE940_RS14210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AE940_RS14225	COG0358	DNA primase activity
AE940_RS14230	COG3119	arylsulfatase activity
AE940_RS14245	COG1629	transport
AE940_RS14245	COG4206	TonB-dependent receptor
AE940_RS14260	COG0302	gtp cyclohydrolase
AE940_RS14270	COG0149	triose-phosphate isomerase activity
AE940_RS14285	COG0739	heme binding
AE940_RS14290	COG0105	UTP biosynthetic process
AE940_RS14295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AE940_RS14300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AE940_RS14320	COG0811	peptide transport
AE940_RS14330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AE940_RS14380	COG1629	transport
AE940_RS14415	COG0039	L-malate dehydrogenase activity
AE940_RS14445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AE940_RS14460	COG4948	Mandelate Racemase Muconate Lactonizing
AE940_RS14480	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AE940_RS14485	COG3118	belongs to the thioredoxin family
AE940_RS14490	COG0489	protein tyrosine kinase activity
AE940_RS14505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AE940_RS14510	COG1722	exodeoxyribonuclease VII activity
AE940_RS14515	COG1570	exodeoxyribonuclease VII activity
AE940_RS14545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AE940_RS14550	COG0179	Fumarylacetoacetate (FAA) hydrolase
AE940_RS14555	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AE940_RS14565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AE940_RS14570	COG0052	Belongs to the universal ribosomal protein uS2 family
AE940_RS14575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AE940_RS14580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AE940_RS14590	COG0017	Asparaginyl-tRNA synthetase
AE940_RS14595	COG1187	pseudouridine synthase activity
AE940_RS14625	COG0110	maltose O-acetyltransferase activity
AE940_RS14635	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS14690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AE940_RS14725	COG1442	glycosyl transferase family 8
AE940_RS14725	COG1216	Glycosyl transferase, family 2
AE940_RS14750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AE940_RS14780	COG0297	glycogen (starch) synthase activity
AE940_RS14875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AE940_RS14890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AE940_RS14905	COG0516	GMP reductase activity
AE940_RS14905	COG0517	IMP dehydrogenase activity
AE940_RS14910	COG0514	ATP-dependent DNA helicase (RecQ)
AE940_RS14915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AE940_RS14935	COG0724	RNA recognition motif
AE940_RS14945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AE940_RS14950	COG1127	ABC transporter
AE940_RS14955	COG2197	response regulator
AE940_RS14960	COG1160	GTP binding
AE940_RS14965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AE940_RS14970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AE940_RS15010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AE940_RS15015	COG0470	DNA polymerase III
AE940_RS15020	COG1774	PSP1 C-terminal conserved region
AE940_RS15030	COG0772	Belongs to the SEDS family
AE940_RS15045	COG1792	Involved in formation and maintenance of cell shape
AE940_RS15055	COG0138	bifunctional purine biosynthesis protein purh
AE940_RS15060	COG3590	peptidase
AE940_RS15065	COG0488	(ABC) transporter
AE940_RS15090	COG0784	Response regulator, receiver
AE940_RS15090	COG2205	protein histidine kinase activity
AE940_RS15095	COG0534	Mate efflux family protein
AE940_RS15100	COG0612	Peptidase, M16
AE940_RS15120	COG0564	pseudouridine synthase activity
AE940_RS15155	COG2312	Erythromycin esterase
AE940_RS15175	COG1131	(ABC) transporter
AE940_RS15255	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AE940_RS15275	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
AE940_RS15295	COG1696	Membrane protein involved in D-alanine export
AE940_RS15335	COG2986	histidine ammonia-lyase
AE940_RS15345	COG1228	amidohydrolase
AE940_RS15355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AE940_RS15380	COG0203	ribosomal protein L17
AE940_RS15385	COG0202	RNA polymerase activity
AE940_RS15390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AE940_RS15395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AE940_RS15400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AE940_RS15405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AE940_RS15420	COG0200	Binds to the 23S rRNA
AE940_RS15425	COG1841	ribosomal large subunit assembly
AE940_RS15430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AE940_RS15435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AE940_RS15440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AE940_RS15445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AE940_RS15450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AE940_RS15455	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AE940_RS15460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AE940_RS15465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AE940_RS15470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AE940_RS15475	COG0255	Belongs to the universal ribosomal protein uL29 family
AE940_RS15480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AE940_RS15485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AE940_RS15490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AE940_RS15495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AE940_RS15500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AE940_RS15505	COG0089	rRNA binding
AE940_RS15510	COG0088	Forms part of the polypeptide exit tunnel
AE940_RS15515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AE940_RS15520	COG0051	transcription antitermination factor activity, RNA binding
AE940_RS15525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AE940_RS15530	COG0049	tRNA binding
AE940_RS15535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AE940_RS15570	COG0085	RNA polymerase activity
AE940_RS15575	COG0222	ribosome binding
AE940_RS15580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AE940_RS15585	COG0081	regulation of translation
AE940_RS15590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AE940_RS15635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AE940_RS15640	COG4974	Belongs to the 'phage' integrase family
AE940_RS15645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AE940_RS15655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AE940_RS15665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AE940_RS15670	COG1480	7TM receptor with intracellular HD hydrolase
AE940_RS15675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AE940_RS15685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AE940_RS15700	COG1027	Aspartate ammonia-lyase
AE940_RS15705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AE940_RS15710	COG0252	asparaginase activity
AE940_RS15720	COG0535	radical SAM domain protein
AE940_RS15785	COG2096	Adenosyltransferase
AE940_RS15835	COG0657	acetylesterase activity
AE940_RS15835	COG2755	lipolytic protein G-D-S-L family
AE940_RS15845	COG3275	phosphorelay sensor kinase activity
AE940_RS15850	COG3279	Response regulator of the LytR AlgR family
AE940_RS15865	COG4206	TonB-dependent receptor
AE940_RS15885	COG2197	response regulator
AE940_RS15900	COG0662	Cupin 2, conserved barrel domain protein
AE940_RS15900	COG2207	Transcriptional regulator
AE940_RS15905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AE940_RS15930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AE940_RS15975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AE940_RS15985	COG1185	polyribonucleotide nucleotidyltransferase activity
AE940_RS16000	COG4771	TonB-dependent receptor
AE940_RS16025	COG3426	butyrate kinase activity
AE940_RS16030	COG0280	phosphate acetyltransferase
AE940_RS16040	COG1619	proteins homologs of microcin C7 resistance protein MccF
AE940_RS16045	COG2234	aminopeptidase activity
AE940_RS16050	COG2166	iron-sulfur cluster assembly
AE940_RS16055	COG3655	Transcriptional regulator
AE940_RS16065	COG1266	CAAX protease self-immunity
AE940_RS16070	COG0196	riboflavin kinase activity
AE940_RS16075	COG1011	Hydrolase
AE940_RS16080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AE940_RS16085	COG2205	protein histidine kinase activity
AE940_RS16085	COG0784	Response regulator, receiver
AE940_RS16090	COG1773	rubredoxin
AE940_RS16095	COG1283	sodium-dependent phosphate transmembrane transporter activity
AE940_RS16105	COG2205	protein histidine kinase activity
AE940_RS16130	COG0006	proline dipeptidase activity
AE940_RS16145	COG0509	glycine decarboxylation via glycine cleavage system
AE940_RS16150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AE940_RS16155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AE940_RS16175	COG0702	epimerase
AE940_RS16180	COG4771	TonB-dependent receptor
AE940_RS16195	COG0793	Belongs to the peptidase S41A family
AE940_RS16200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AE940_RS16235	COG4771	TonB-dependent receptor
AE940_RS16245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AE940_RS16250	COG1882	Formate acetyltransferase
AE940_RS16255	COG2814	Major facilitator Superfamily
AE940_RS16255	COG0477	Major facilitator Superfamily
AE940_RS16275	COG1040	competence protein
AE940_RS16280	COG0483	inositol monophosphate 1-phosphatase activity
AE940_RS16290	COG3345	alpha-galactosidase
AE940_RS16315	COG3475	LICD family
AE940_RS16320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AE940_RS16355	COG1442	glycosyl transferase family 8
AE940_RS16430	COG0018	arginyl-trna synthetase
AE940_RS16460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AE940_RS16465	COG0776	regulation of translation
AE940_RS16500	COG1609	Transcriptional regulator
AE940_RS16500	COG2207	Transcriptional regulator
AE940_RS16515	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AE940_RS16515	COG0674	pyruvate-flavodoxin oxidoreductase activity
AE940_RS16520	COG1013	pyruvate-flavodoxin oxidoreductase activity
AE940_RS16530	COG0584	glycerophosphoryl diester phosphodiesterase
AE940_RS16535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AE940_RS16540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AE940_RS16545	COG1629	transport
AE940_RS16560	COG5434	Belongs to the glycosyl hydrolase 28 family
AE940_RS16580	COG1629	transport
AE940_RS16590	COG1217	gtp-binding protein TYPA
AE940_RS16595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AE940_RS16605	COG0318	PFAM AMP-dependent synthetase and ligase
AE940_RS16610	COG4999	Histidine kinase
AE940_RS16610	COG2205	protein histidine kinase activity
AE940_RS16610	COG3437	response regulator, receiver
AE940_RS16610	COG3850	Histidine kinase
AE940_RS16630	COG3119	arylsulfatase activity
AE940_RS16640	COG1629	transport
AE940_RS16640	COG4206	TonB-dependent receptor
AE940_RS16655	COG4591	ABC-type transport system involved in lipoprotein release permease component
AE940_RS16660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AE940_RS16675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AE940_RS16680	COG4974	Belongs to the 'phage' integrase family
AE940_RS16690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AE940_RS16695	COG0606	chelatase, subunit chli
AE940_RS16715	COG0745	RESPONSE REGULATOR receiver
AE940_RS16715	COG2205	protein histidine kinase activity
AE940_RS16715	COG3292	Two component regulator propeller
AE940_RS16780	COG0438	transferase activity, transferring glycosyl groups
AE940_RS16805	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AE940_RS16810	COG0438	transferase activity, transferring glycosyl groups
AE940_RS16820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AE940_RS16825	COG0545	Peptidyl-prolyl cis-trans isomerase
AE940_RS16830	COG0545	Peptidyl-prolyl cis-trans isomerase
AE940_RS16835	COG1522	sequence-specific DNA binding
AE940_RS16855	COG3275	phosphorelay sensor kinase activity
AE940_RS16930	COG4206	TonB-dependent receptor
AE940_RS16930	COG1629	transport
AE940_RS16940	COG2814	Major facilitator Superfamily
AE940_RS16965	COG0745	RESPONSE REGULATOR receiver
AE940_RS16965	COG2205	protein histidine kinase activity
AE940_RS16965	COG3292	Two component regulator propeller
AE940_RS17005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AE940_RS17010	COG0793	Belongs to the peptidase S41A family
AE940_RS17010	COG3409	Peptidoglycan-binding domain 1 protein
AE940_RS17030	COG1053	succinate dehydrogenase
AE940_RS17035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AE940_RS17050	COG4771	TonB-dependent receptor
AE940_RS17075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AE940_RS17075	COG0758	DNA mediated transformation
AE940_RS17085	COG0826	peptidase U32
AE940_RS17095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AE940_RS17110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AE940_RS17115	COG0557	exoribonuclease II activity
AE940_RS17140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AE940_RS17155	COG0012	GTP binding
AE940_RS17160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AE940_RS17165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AE940_RS17175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AE940_RS17185	COG0495	leucyl-tRNA aminoacylation
AE940_RS17190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AE940_RS17200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AE940_RS17220	COG1215	transferase activity, transferring glycosyl groups
AE940_RS17270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AE940_RS17270	COG0731	radical SAM domain protein
AE940_RS17295	COG0659	secondary active sulfate transmembrane transporter activity
AE940_RS17300	COG1592	Rubrerythrin
AE940_RS17305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AE940_RS17325	COG0427	acetyl-CoA hydrolase
AE940_RS17335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AE940_RS17345	COG3250	beta-galactosidase activity
AE940_RS17495	COG2177	Part of the ABC transporter FtsEX involved in
AE940_RS17505	COG1968	undecaprenyl-diphosphatase activity
AE940_RS17510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AE940_RS17515	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AE940_RS17520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AE940_RS17525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AE940_RS17530	COG1611	Belongs to the LOG family
AE940_RS17545	COG0594	ribonuclease P activity
AE940_RS17560	COG0823	Involved in the tonB-independent uptake of proteins
AE940_RS17560	COG4946	Tricorn protease homolog
AE940_RS17560	COG1506	peptidase
AE940_RS17570	COG3119	arylsulfatase activity
AE940_RS17575	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AE940_RS17580	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS17590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AE940_RS17620	COG1121	(ABC) transporter
AE940_RS17630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AE940_RS17630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AE940_RS17645	COG0151	Belongs to the GarS family
AE940_RS17650	COG1506	peptidase
AE940_RS17650	COG0823	Involved in the tonB-independent uptake of proteins
AE940_RS17655	COG0116	Belongs to the methyltransferase superfamily
AE940_RS17660	COG1045	serine acetyltransferase
AE940_RS17665	COG3275	phosphorelay sensor kinase activity
AE940_RS17670	COG3279	Response regulator of the LytR AlgR family
AE940_RS17680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AE940_RS17680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AE940_RS17695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AE940_RS17700	COG1694	Mazg nucleotide pyrophosphohydrolase
AE940_RS17710	COG0322	excinuclease ABC activity
AE940_RS17720	COG0445	tRNA wobble uridine modification
AE940_RS17745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AE940_RS17765	COG2715	membrane protein required for spore maturation
AE940_RS17775	COG2255	four-way junction helicase activity
AE940_RS17790	COG3591	Belongs to the peptidase S1B family
AE940_RS17805	COG0513	Belongs to the DEAD box helicase family
AE940_RS17815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AE940_RS17830	COG0612	Peptidase, M16
AE940_RS17845	COG1312	Catalyzes the dehydration of D-mannonate
AE940_RS17850	COG1028	Short-chain dehydrogenase reductase Sdr
AE940_RS17860	COG0681	Belongs to the peptidase S26 family
AE940_RS17865	COG0681	Belongs to the peptidase S26 family
AE940_RS17870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AE940_RS17900	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AE940_RS17915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AE940_RS17920	COG3250	beta-galactosidase activity
AE940_RS17940	COG0215	cysteine-tRNA ligase activity
AE940_RS17945	COG0561	phosphatase activity
AE940_RS17950	COG0745	RESPONSE REGULATOR receiver
AE940_RS17965	COG0745	RESPONSE REGULATOR receiver
AE940_RS17970	COG5002	protein histidine kinase activity
AE940_RS17975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AE940_RS17990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AE940_RS17995	COG0482	sulfurtransferase activity
AE940_RS18005	COG0205	6-phosphofructokinase activity
AE940_RS18010	COG0571	ribonuclease III activity
AE940_RS18015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AE940_RS18020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AE940_RS18025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AE940_RS18030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AE940_RS18045	COG1442	glycosyl transferase family 8
AE940_RS18055	COG1215	transferase activity, transferring glycosyl groups
AE940_RS18060	COG1216	Glycosyl transferase, family 2
AE940_RS18060	COG1442	glycosyl transferase family 8
AE940_RS18065	COG1132	(ABC) transporter
AE940_RS18075	COG0328	RNA-DNA hybrid ribonuclease activity
AE940_RS18075	COG3341	Caulimovirus viroplasmin
AE940_RS18100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AE940_RS18110	COG0326	Molecular chaperone. Has ATPase activity
AE940_RS18120	COG1166	arginine decarboxylase activity
AE940_RS18125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AE940_RS18195	COG1454	alcohol dehydrogenase
AE940_RS18200	COG0235	Class ii aldolase
AE940_RS18205	COG1070	Carbohydrate kinase
AE940_RS18210	COG0738	Major facilitator superfamily
AE940_RS18215	COG0779	Required for maturation of 30S ribosomal subunits
AE940_RS18220	COG0195	Participates in both transcription termination and antitermination
AE940_RS18225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AE940_RS18235	COG0719	Fe-S assembly protein
AE940_RS18245	COG0396	ATPase activity
AE940_RS18250	COG0719	Fe-S assembly protein
AE940_RS18255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AE940_RS18260	COG0393	Putative heavy-metal-binding
AE940_RS18265	COG3345	alpha-galactosidase
AE940_RS18275	COG1629	transport
AE940_RS18300	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AE940_RS18310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AE940_RS18320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AE940_RS18325	COG2205	protein histidine kinase activity
AE940_RS18325	COG2202	Pas domain
AE940_RS18345	COG0187	DNA topoisomerase II activity
AE940_RS18350	COG0268	Binds directly to 16S ribosomal RNA
AE940_RS18360	COG1381	Involved in DNA repair and RecF pathway recombination
AE940_RS18365	COG1610	YqeY-like protein
AE940_RS18370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AE940_RS18385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AE940_RS18390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AE940_RS18395	COG0772	Belongs to the SEDS family
AE940_RS18400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AE940_RS18405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AE940_RS18410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AE940_RS18425	COG0275	rRNA processing
AE940_RS18430	COG2001	Belongs to the MraZ family
AE940_RS18445	COG4771	TonB-dependent receptor
AE940_RS18470	COG0756	dUTP diphosphatase activity
AE940_RS18485	COG4942	peptidase
AE940_RS18490	COG3292	Two component regulator propeller
AE940_RS18490	COG2205	protein histidine kinase activity
AE940_RS18490	COG0745	RESPONSE REGULATOR receiver
AE940_RS18495	COG3940	Belongs to the glycosyl hydrolase 43 family
AE940_RS18510	COG3250	beta-galactosidase activity
AE940_RS18525	COG3940	Belongs to the glycosyl hydrolase 43 family
AE940_RS18545	COG0383	alpha-mannosidase activity
AE940_RS18545	COG0383	alpha-mannosidase activity
AE940_RS18550	COG1629	transport
AE940_RS18550	COG4206	TonB-dependent receptor
AE940_RS18575	COG3507	Belongs to the glycosyl hydrolase 43 family
AE940_RS18600	COG3537	Alpha-1,2-mannosidase
AE940_RS18610	COG2017	converts alpha-aldose to the beta-anomer
AE940_RS18665	COG3408	Glycogen debranching enzyme
AE940_RS18670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AE940_RS18675	COG1022	Amp-dependent synthetase and ligase
AE940_RS18690	COG2954	triphosphatase activity
AE940_RS18710	COG3250	beta-galactosidase activity
AE940_RS18715	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AE940_RS18725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AE940_RS18740	COG1629	transport
AE940_RS18740	COG4206	TonB-dependent receptor
AE940_RS18745	COG2205	protein histidine kinase activity
AE940_RS18745	COG0745	RESPONSE REGULATOR receiver
AE940_RS18745	COG3292	Two component regulator propeller
AE940_RS18750	COG3292	Two component regulator propeller
AE940_RS18750	COG2205	protein histidine kinase activity
AE940_RS18750	COG0745	RESPONSE REGULATOR receiver
AE940_RS18775	COG4771	TonB-dependent receptor
AE940_RS18790	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
AE940_RS18810	COG4771	TonB-dependent receptor
AE940_RS18835	COG0423	glycine-tRNA ligase activity
AE940_RS18840	COG0545	Peptidyl-prolyl cis-trans isomerase
AE940_RS18870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AE940_RS18880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AE940_RS18900	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AE940_RS18920	COG3876	Protein conserved in bacteria
AE940_RS18955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AE940_RS18960	COG3876	Protein conserved in bacteria
AE940_RS18965	COG0702	epimerase
AE940_RS18970	COG1629	transport
AE940_RS18970	COG4206	TonB-dependent receptor
AE940_RS18985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AE940_RS18990	COG0475	glutathione-regulated potassium exporter activity
AE940_RS18990	COG0589	response to stress
AE940_RS18995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AE940_RS19000	COG1136	(ABC) transporter
AE940_RS19010	COG0733	neurotransmitter:sodium symporter activity
AE940_RS19020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AE940_RS19030	COG0076	glutamate decarboxylase activity
AE940_RS19035	COG2066	Belongs to the glutaminase family
AE940_RS19040	COG5002	protein histidine kinase activity
AE940_RS19040	COG2198	Histidine kinase
AE940_RS19040	COG0784	Response regulator, receiver
AE940_RS19045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AE940_RS19050	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AE940_RS19150	COG1346	cytolysis
AE940_RS19175	COG0280	phosphate acetyltransferase
AE940_RS19180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AE940_RS19185	COG1785	Belongs to the alkaline phosphatase family
AE940_RS19190	COG2151	metal-sulfur cluster biosynthetic enzyme
AE940_RS19195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AE940_RS19200	COG2003	Belongs to the UPF0758 family
AE940_RS19205	COG0463	Glycosyl transferase, family 2
AE940_RS19205	COG1216	Glycosyl transferase, family 2
AE940_RS19215	COG2815	serine threonine protein kinase
AE940_RS19215	COG0515	serine threonine protein kinase
AE940_RS19220	COG0564	pseudouridine synthase activity
AE940_RS19260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AE940_RS19265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AE940_RS19275	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AE940_RS19295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AE940_RS19305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AE940_RS19305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AE940_RS19310	COG2890	protein-(glutamine-N5) methyltransferase activity
AE940_RS19315	COG2137	regulation of response to DNA damage stimulus
AE940_RS19320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AE940_RS19355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AE940_RS19360	COG1917	Cupin 2, conserved barrel domain protein
AE940_RS19360	COG1396	sequence-specific DNA binding
AE940_RS19365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AE940_RS19370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AE940_RS19375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AE940_RS19380	COG0137	argininosuccinate synthase activity
AE940_RS19390	COG1438	arginine binding
AE940_RS19405	COG0784	Response regulator, receiver
AE940_RS19405	COG2205	protein histidine kinase activity
AE940_RS19410	COG0531	amino acid
AE940_RS19420	COG0039	L-malate dehydrogenase activity
AE940_RS19425	COG2996	Protein conserved in bacteria
AE940_RS19445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AE940_RS19450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AE940_RS19475	COG1629	transport
AE940_RS19500	COG1136	(ABC) transporter
AE940_RS19500	COG0577	efflux transmembrane transporter activity
AE940_RS19505	COG1136	(ABC) transporter
AE940_RS19505	COG0577	efflux transmembrane transporter activity
AE940_RS19510	COG1136	(ABC) transporter
AE940_RS19515	COG1940	carbohydrate kinase activity
AE940_RS19520	COG0335	large ribosomal subunit rRNA binding
AE940_RS19525	COG0737	Belongs to the 5'-nucleotidase family
AE940_RS19530	COG0737	Belongs to the 5'-nucleotidase family
AE940_RS19535	COG1472	Belongs to the glycosyl hydrolase 3 family
AE940_RS19540	COG1472	Belongs to the glycosyl hydrolase 3 family
AE940_RS19545	COG1629	transport
AE940_RS19545	COG4206	TonB-dependent receptor
AE940_RS19555	COG3119	arylsulfatase activity
AE940_RS19580	COG0446	pyridine nucleotide-disulphide oxidoreductase
AE940_RS19590	COG2204	response regulator
AE940_RS19595	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AE940_RS19615	COG2205	protein histidine kinase activity
AE940_RS19620	COG5002	protein histidine kinase activity
AE940_RS19635	COG4771	TonB-dependent receptor
AE940_RS19680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AE940_RS19680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AE940_RS19685	COG0436	Aminotransferase
AE940_RS19690	COG3250	beta-galactosidase activity
AE940_RS19705	COG0826	peptidase U32
AE940_RS19715	COG4771	TonB-dependent receptor
AE940_RS19720	COG2197	response regulator
AE940_RS19725	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AE940_RS19735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AE940_RS19745	COG0252	asparaginase activity
AE940_RS19750	COG0527	aspartate kinase activity
AE940_RS19750	COG0460	homoserine dehydrogenase
AE940_RS19755	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AE940_RS19760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine