locus-tag	class	description
BF0004	COG1215	transferase activity, transferring glycosyl groups
BF0015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BF0015	COG0731	radical SAM domain protein
BF0020	COG0659	secondary active sulfate transmembrane transporter activity
BF0021	COG1592	Rubrerythrin
BF0022	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BF0026	COG0427	acetyl-CoA hydrolase
BF0028	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BF0030	COG3250	beta-galactosidase activity
BF0054	COG2177	Part of the ABC transporter FtsEX involved in
BF0057	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BF0058	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BF0059	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BF0061	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BF0062	COG1611	Belongs to the LOG family
BF0065	COG0594	ribonuclease P activity
BF0066	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BF0069	COG1506	peptidase
BF0069	COG0823	Involved in the tonB-independent uptake of proteins
BF0069	COG4946	Tricorn protease homolog
BF0070	COG3119	arylsulfatase activity
BF0072	COG1028	Short-chain dehydrogenase reductase Sdr
BF0074	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BF0079	COG1121	(ABC) transporter
BF0081	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF0081	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BF0084	COG0151	Belongs to the GarS family
BF0085	COG0823	Involved in the tonB-independent uptake of proteins
BF0085	COG1506	peptidase
BF0086	COG0116	Belongs to the methyltransferase superfamily
BF0087	COG1045	serine acetyltransferase
BF0088	COG3275	phosphorelay sensor kinase activity
BF0089	COG3279	Response regulator of the LytR AlgR family
BF0091	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF0091	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF0095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BF0096	COG1694	Mazg nucleotide pyrophosphohydrolase
BF0098	COG0322	excinuclease ABC activity
BF0114	COG0358	DNA primase activity
BF0139	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF0139	COG0784	Response regulator, receiver
BF0139	COG2205	protein histidine kinase activity
BF0139	COG2198	Histidine kinase
BF0144	COG0551	DNA topoisomerase type I activity
BF0144	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF0152	COG4974	Belongs to the 'phage' integrase family
BF0156	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BF0161	COG2715	membrane protein required for spore maturation
BF0163	COG2255	four-way junction helicase activity
BF0166	COG3591	Belongs to the peptidase S1B family
BF0169	COG0513	Belongs to the DEAD box helicase family
BF0171	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BF0174	COG0612	Peptidase, M16
BF0178	COG1028	Short-chain dehydrogenase reductase Sdr
BF0180	COG0681	Belongs to the peptidase S26 family
BF0181	COG0681	Belongs to the peptidase S26 family
BF0182	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BF0188	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF0191	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF0192	COG3250	beta-galactosidase activity
BF0198	COG0561	phosphatase activity
BF0199	COG0745	RESPONSE REGULATOR receiver
BF0209	COG0745	RESPONSE REGULATOR receiver
BF0210	COG5002	protein histidine kinase activity
BF0211	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BF0214	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BF0217	COG0205	6-phosphofructokinase activity
BF0219	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BF0220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BF0221	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BF0225	COG1442	glycosyl transferase family 8
BF0227	COG1215	transferase activity, transferring glycosyl groups
BF0228	COG1442	glycosyl transferase family 8
BF0228	COG1216	Glycosyl transferase, family 2
BF0229	COG1132	(ABC) transporter
BF0231	COG3341	Caulimovirus viroplasmin
BF0231	COG0328	RNA-DNA hybrid ribonuclease activity
BF0235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BF0237	COG0326	Molecular chaperone. Has ATPase activity
BF0239	COG1166	arginine decarboxylase activity
BF0240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BF0254	COG1454	alcohol dehydrogenase
BF0255	COG0235	Class ii aldolase
BF0256	COG1070	Carbohydrate kinase
BF0257	COG0738	Major facilitator superfamily
BF0261	COG0779	Required for maturation of 30S ribosomal subunits
BF0262	COG0195	Participates in both transcription termination and antitermination
BF0263	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BF0265	COG0719	Fe-S assembly protein
BF0267	COG0396	ATPase activity
BF0268	COG0719	Fe-S assembly protein
BF0269	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BF0270	COG0393	Putative heavy-metal-binding
BF0271	COG3345	alpha-galactosidase
BF0273	COG1629	transport
BF0289	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BF0293	COG2205	protein histidine kinase activity
BF0293	COG2202	Pas domain
BF0297	COG0187	DNA topoisomerase II activity
BF0298	COG0268	Binds directly to 16S ribosomal RNA
BF0300	COG1381	Involved in DNA repair and RecF pathway recombination
BF0301	COG1610	YqeY-like protein
BF0302	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BF0305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BF0306	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BF0307	COG0772	Belongs to the SEDS family
BF0308	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BF0309	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF0314	COG2001	Belongs to the MraZ family
BF0318	COG4771	TonB-dependent receptor
BF0324	COG0756	dUTP diphosphatase activity
BF0327	COG4942	peptidase
BF0328	COG2205	protein histidine kinase activity
BF0328	COG0745	RESPONSE REGULATOR receiver
BF0328	COG3292	Two component regulator propeller
BF0329	COG3940	Belongs to the glycosyl hydrolase 43 family
BF0332	COG3250	beta-galactosidase activity
BF0335	COG3940	Belongs to the glycosyl hydrolase 43 family
BF0339	COG0383	alpha-mannosidase activity
BF0339	COG0383	alpha-mannosidase activity
BF0340	COG4206	TonB-dependent receptor
BF0340	COG1629	transport
BF0344	COG3507	Belongs to the glycosyl hydrolase 43 family
BF0350	COG3537	Alpha-1,2-mannosidase
BF0352	COG2017	converts alpha-aldose to the beta-anomer
BF0371	COG3408	Glycogen debranching enzyme
BF0372	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BF0373	COG1022	Amp-dependent synthetase and ligase
BF0376	COG2954	triphosphatase activity
BF0380	COG3250	beta-galactosidase activity
BF0381	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF0383	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BF0387	COG1629	transport
BF0387	COG4206	TonB-dependent receptor
BF0388	COG3292	Two component regulator propeller
BF0388	COG2205	protein histidine kinase activity
BF0388	COG0745	RESPONSE REGULATOR receiver
BF0389	COG0745	RESPONSE REGULATOR receiver
BF0389	COG3292	Two component regulator propeller
BF0389	COG2205	protein histidine kinase activity
BF0394	COG4771	TonB-dependent receptor
BF0407	COG4771	TonB-dependent receptor
BF0412	COG0423	glycine-tRNA ligase activity
BF0413	COG0545	Peptidyl-prolyl cis-trans isomerase
BF0422	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BF0430	COG3876	Protein conserved in bacteria
BF0437	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF0438	COG3876	Protein conserved in bacteria
BF0439	COG0702	epimerase
BF0440	COG1629	transport
BF0440	COG4206	TonB-dependent receptor
BF0444	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BF0445	COG0589	response to stress
BF0445	COG0475	glutathione-regulated potassium exporter activity
BF0446	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BF0449	COG0733	neurotransmitter:sodium symporter activity
BF0451	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BF0454	COG0076	glutamate decarboxylase activity
BF0456	COG2198	Histidine kinase
BF0456	COG5002	protein histidine kinase activity
BF0456	COG0784	Response regulator, receiver
BF0457	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BF0458	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BF0473	COG1346	cytolysis
BF0478	COG0280	phosphate acetyltransferase
BF0479	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BF0480	COG1785	Belongs to the alkaline phosphatase family
BF0481	COG2151	metal-sulfur cluster biosynthetic enzyme
BF0482	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF0483	COG2003	Belongs to the UPF0758 family
BF0484	COG1216	Glycosyl transferase, family 2
BF0484	COG0463	Glycosyl transferase, family 2
BF0487	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BF0488	COG2815	serine threonine protein kinase
BF0488	COG0515	serine threonine protein kinase
BF0489	COG0564	pseudouridine synthase activity
BF0498	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BF0499	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BF0501	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BF0505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BF0507	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BF0507	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BF0508	COG2890	protein-(glutamine-N5) methyltransferase activity
BF0509	COG2137	regulation of response to DNA damage stimulus
BF0510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BF0528	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BF0529	COG1917	Cupin 2, conserved barrel domain protein
BF0529	COG1396	sequence-specific DNA binding
BF0530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF0531	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BF0533	COG0137	argininosuccinate synthase activity
BF0538	COG4999	Histidine kinase
BF0538	COG3850	Histidine kinase
BF0538	COG3437	response regulator, receiver
BF0538	COG2205	protein histidine kinase activity
BF0539	COG0531	amino acid
BF0541	COG0039	L-malate dehydrogenase activity
BF0542	COG2996	Protein conserved in bacteria
BF0546	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF0548	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BF0553	COG1629	transport
BF0559	COG0577	efflux transmembrane transporter activity
BF0559	COG1136	(ABC) transporter
BF0560	COG1136	(ABC) transporter
BF0560	COG0577	efflux transmembrane transporter activity
BF0561	COG1136	(ABC) transporter
BF0562	COG1940	carbohydrate kinase activity
BF0563	COG0335	large ribosomal subunit rRNA binding
BF0564	COG0737	Belongs to the 5'-nucleotidase family
BF0565	COG0737	Belongs to the 5'-nucleotidase family
BF0566	COG1472	Belongs to the glycosyl hydrolase 3 family
BF0567	COG1472	Belongs to the glycosyl hydrolase 3 family
BF0568	COG4206	TonB-dependent receptor
BF0568	COG1629	transport
BF0570	COG3119	arylsulfatase activity
BF0575	COG0446	pyridine nucleotide-disulphide oxidoreductase
BF0577	COG2204	response regulator
BF0578	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BF0582	COG2205	protein histidine kinase activity
BF0583	COG5002	protein histidine kinase activity
BF0586	COG4771	TonB-dependent receptor
BF0594	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BF0594	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BF0595	COG0436	Aminotransferase
BF0596	COG3250	beta-galactosidase activity
BF0599	COG0826	peptidase U32
BF0601	COG4771	TonB-dependent receptor
BF0602	COG2197	response regulator
BF0603	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BF0605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BF0607	COG0252	asparaginase activity
BF0608	COG0527	aspartate kinase activity
BF0608	COG0460	homoserine dehydrogenase
BF0609	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BF0610	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BF0621	COG4206	TonB-dependent receptor
BF0621	COG1629	transport
BF0622	COG0702	epimerase
BF0623	COG3250	beta-galactosidase activity
BF0625	COG3507	Belongs to the glycosyl hydrolase 43 family
BF0628	COG4771	TonB-dependent receptor
BF0649	COG0546	phosphoglycolate phosphatase activity
BF0658	COG0628	permease
BF0661	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BF0664	COG2095	MarC family integral membrane protein
BF0666	COG1629	transport
BF0666	COG4206	TonB-dependent receptor
BF0667	COG4974	Belongs to the 'phage' integrase family
BF0668	COG4206	TonB-dependent receptor
BF0668	COG1629	transport
BF0670	COG4771	TonB-dependent receptor
BF0671	COG0702	epimerase
BF0672	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BF0676	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BF0676	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BF0679	COG0531	amino acid
BF0683	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF0684	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF0689	COG0233	cytoplasmic translational termination
BF0693	COG0443	Heat shock 70 kDa protein
BF0697	COG0528	UMP kinase activity
BF0698	COG0534	Mate efflux family protein
BF0706	COG0792	nuclease activity
BF0710	COG1183	phosphatidylcholine synthase activity
BF0711	COG0688	phosphatidylethanolamine metabolic process
BF0713	COG3118	belongs to the thioredoxin family
BF0721	COG0714	Associated with various cellular activities
BF0724	COG0802	atpase or kinase
BF0725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BF0727	COG2234	aminopeptidase activity
BF0732	COG1629	transport
BF0736	COG3250	beta-galactosidase activity
BF0739	COG0784	Response regulator, receiver
BF0739	COG2205	protein histidine kinase activity
BF0743	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BF0746	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF0747	COG0742	ribosomal rna small subunit methyltransferase
BF0752	COG4771	TonB-dependent receptor
BF0754	COG3537	Alpha-1,2-mannosidase
BF0757	COG3537	Alpha-1,2-mannosidase
BF0759	COG2814	Major facilitator Superfamily
BF0762	COG0739	heme binding
BF0764	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BF0765	COG3942	CHAP domain
BF0765	COG1388	LysM domain
BF0767	COG1475	DNA binding
BF0768	COG1192	Involved in chromosome partitioning
BF0770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BF0771	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF0773	COG4589	Belongs to the CDS family
BF0774	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BF0775	COG0799	negative regulation of ribosome biogenesis
BF0777	COG2239	Acts as a magnesium transporter
BF0778	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BF0780	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF0793	COG0668	transmembrane transport
BF0794	COG0662	Cupin 2, conserved barrel domain protein
BF0794	COG2207	Transcriptional regulator
BF0805	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BF0808	COG2244	polysaccharide biosynthetic process
BF0813	COG1216	Glycosyl transferase, family 2
BF0817	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF0820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF0822	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF0826	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF0827	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF0831	COG0667	Aldo Keto reductase
BF0832	COG1472	Belongs to the glycosyl hydrolase 3 family
BF0833	COG4771	TonB-dependent receptor
BF0834	COG0702	epimerase
BF0843	COG5012	cobalamin binding
BF0846	COG4124	Belongs to the glycosyl hydrolase 26 family
BF0847	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BF0848	COG2211	Major facilitator Superfamily
BF0849	COG2942	2-epimerase
BF0859	COG0784	Response regulator, receiver
BF0859	COG2205	protein histidine kinase activity
BF0859	COG5002	protein histidine kinase activity
BF0861	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF0862	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BF0863	COG0713	ATP synthesis coupled electron transport
BF0864	COG0839	Belongs to the complex I subunit 6 family
BF0866	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BF0867	COG0649	NAD binding
BF0867	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF0868	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF0869	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF0871	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF0872	COG0569	domain protein
BF0873	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BF0875	COG1073	alpha beta
BF0878	COG3119	arylsulfatase activity
BF0881	COG3119	arylsulfatase activity
BF0883	COG4771	TonB-dependent receptor
BF0884	COG0745	RESPONSE REGULATOR receiver
BF0884	COG2205	protein histidine kinase activity
BF0884	COG3292	Two component regulator propeller
BF0885	COG2271	Major facilitator Superfamily
BF0890	COG0805	protein transport
BF0891	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BF0892	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BF0905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF0906	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BF0906	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BF0907	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BF0908	COG1078	dGTPase activity
BF0910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BF0911	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BF0913	COG1704	LemA family
BF0916	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BF0917	COG2226	methyltransferase
BF0918	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BF0919	COG1702	phosphate starvation-inducible protein PhoH
BF0921	COG2268	Band 7 protein
BF0929	COG3250	beta-galactosidase activity
BF0930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF0937	COG0457	Tetratricopeptide repeat
BF0938	COG2814	Major facilitator Superfamily
BF0943	COG0561	phosphatase activity
BF0944	COG1629	transport
BF0944	COG4206	TonB-dependent receptor
BF0946	COG4771	TonB-dependent receptor
BF0948	COG1629	transport
BF0948	COG4206	TonB-dependent receptor
BF0952	COG1629	transport
BF0952	COG4206	TonB-dependent receptor
BF0953	COG0702	epimerase
BF0962	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BF0963	COG0793	Belongs to the peptidase S41A family
BF0964	COG2131	deaminase
BF0966	COG0339	signal peptide processing
BF0968	COG1970	mechanosensitive ion channel activity
BF0969	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BF0969	COG0519	Catalyzes the synthesis of GMP from XMP
BF0971	COG4206	TonB-dependent receptor
BF0971	COG1629	transport
BF0972	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BF0982	COG1242	4 iron, 4 sulfur cluster binding
BF0984	COG0363	glucosamine-6-phosphate deaminase activity
BF0986	COG0009	L-threonylcarbamoyladenylate synthase
BF0988	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BF0989	COG0561	phosphatase activity
BF0990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BF0991	COG2873	o-acetylhomoserine
BF1002	COG0297	glycogen (starch) synthase activity
BF1004	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BF1005	COG0543	2 iron, 2 sulfur cluster binding
BF1007	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BF1009	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BF1010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BF1014	COG0546	phosphoglycolate phosphatase activity
BF1015	COG0791	NLP P60 protein
BF1018	COG0612	Peptidase, M16
BF1019	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BF1020	COG1597	lipid kinase activity
BF1023	COG1136	(ABC) transporter
BF1027	COG2211	Major facilitator Superfamily
BF1030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BF1033	COG1674	ftsk spoiiie
BF1035	COG0492	ferredoxin-NADP+ reductase activity
BF1036	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF1045	COG1595	DNA-templated transcription, initiation
BF1048	COG3956	TIGRFAM MazG family protein
BF1050	COG0525	valine-tRNA ligase activity
BF1051	COG0784	Response regulator, receiver
BF1051	COG2205	protein histidine kinase activity
BF1051	COG2198	Histidine kinase
BF1056	COG4771	TonB-dependent receptor
BF1059	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BF1062	COG4771	TonB-dependent receptor
BF1063	COG0702	epimerase
BF1064	COG3119	arylsulfatase activity
BF1065	COG3119	arylsulfatase activity
BF1069	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
BF1076	COG1253	flavin adenine dinucleotide binding
BF1080	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BF1088	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BF1090	COG2226	methyltransferase
BF1099	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BF1108	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BF1110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF1112	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF1117	COG4771	TonB-dependent receptor
BF1119	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BF1120	COG0563	adenylate kinase activity
BF1121	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BF1122	COG1496	oxidoreductase activity
BF1126	COG2706	6-phosphogluconolactonase activity
BF1134	COG1288	antiporter activity
BF1141	COG0564	pseudouridine synthase activity
BF1144	COG1501	Belongs to the glycosyl hydrolase 31 family
BF1145	COG1028	Short-chain dehydrogenase reductase Sdr
BF1152	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BF1154	COG0419	ATPase involved in DNA repair
BF1168	COG4974	Belongs to the 'phage' integrase family
BF1172	COG0784	Response regulator, receiver
BF1172	COG5002	protein histidine kinase activity
BF1173	COG2910	NAD(P)H-binding
BF1174	COG2176	DNA-directed DNA polymerase activity
BF1176	COG4864	UPF0365 protein
BF1179	COG0037	tRNA processing
BF1182	COG1477	protein flavinylation
BF1183	COG1971	Probably functions as a manganese efflux pump
BF1186	COG0463	Glycosyl transferase, family 2
BF1188	COG0148	phosphopyruvate hydratase activity
BF1190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BF1191	COG1082	Xylose isomerase domain protein TIM barrel
BF1195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BF1196	COG0193	aminoacyl-tRNA hydrolase activity
BF1197	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BF1199	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BF1200	COG1862	Preprotein translocase
BF1205	COG0542	response to heat
BF1207	COG0583	DNA-binding transcription factor activity
BF1208	COG2855	membrane
BF1211	COG1595	DNA-templated transcription, initiation
BF1214	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BF1219	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF1225	COG0443	Heat shock 70 kDa protein
BF1228	COG4974	Belongs to the 'phage' integrase family
BF1231	COG1787	Restriction endonuclease
BF1231	COG1715	Restriction endonuclease
BF1234	COG0358	DNA primase activity
BF1237	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BF1241	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BF1242	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BF1243	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF1247	COG1501	Belongs to the glycosyl hydrolase 31 family
BF1253	COG1629	transport
BF1253	COG4206	TonB-dependent receptor
BF1255	COG1408	metallophosphoesterase
BF1256	COG1368	sulfuric ester hydrolase activity
BF1258	COG3634	alkyl hydroperoxide reductase activity
BF1265	COG1760	l-serine dehydratase
BF1266	COG0598	Magnesium transport protein CorA
BF1267	COG1193	negative regulation of DNA recombination
BF1279	COG0358	DNA primase activity
BF1290	COG1063	alcohol dehydrogenase
BF1293	COG3119	arylsulfatase activity
BF1294	COG0784	Response regulator, receiver
BF1294	COG5002	protein histidine kinase activity
BF1295	COG2855	membrane
BF1296	COG2217	Heavy metal translocating P-type atpase
BF1298	COG2885	chlorophyll binding
BF1300	COG3189	MarR family transcriptional regulator
BF1301	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BF1302	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF1303	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BF1307	COG4651	solute:proton antiporter activity
BF1307	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BF1308	COG1280	lysine exporter protein (LysE YggA)
BF1311	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BF1314	COG0561	phosphatase activity
BF1315	COG1169	isochorismate synthase
BF1316	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BF1319	COG4948	Mandelate Racemase Muconate Lactonizing
BF1323	COG1082	Xylose isomerase domain protein TIM barrel
BF1326	COG4771	TonB-dependent receptor
BF1332	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BF1333	COG0783	Belongs to the Dps family
BF1334	COG0583	DNA-binding transcription factor activity
BF1338	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BF1340	COG4974	Belongs to the 'phage' integrase family
BF1373	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF1373	COG0551	DNA topoisomerase type I activity
BF1385	COG0666	response to abiotic stimulus
BF1390	COG4974	Belongs to the 'phage' integrase family
BF1391	COG1309	transcriptional regulator
BF1399	COG1253	flavin adenine dinucleotide binding
BF1400	COG0501	Belongs to the peptidase M48B family
BF1406	COG2873	o-acetylhomoserine
BF1408	COG2197	response regulator
BF1410	COG1757	Na H antiporter
BF1413	COG2814	Major facilitator Superfamily
BF1414	COG4953	penicillin-binding protein 1C
BF1415	COG2373	Large extracellular alpha-helical protein
BF1417	COG1918	ferrous iron import across plasma membrane
BF1417	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BF1430	COG1086	Polysaccharide biosynthesis protein
BF1431	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF1434	COG1028	Short-chain dehydrogenase reductase Sdr
BF1436	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BF1441	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BF1442	COG0463	Glycosyl transferase, family 2
BF1442	COG1216	Glycosyl transferase, family 2
BF1444	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF1445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF1446	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF1447	COG0471	metal ion transport
BF1447	COG0490	domain, Protein
BF1450	COG0346	lactoylglutathione lyase activity
BF1453	COG0259	pyridoxamine-phosphate oxidase activity
BF1454	COG1741	Belongs to the pirin family
BF1459	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BF1465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BF1467	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BF1470	COG1595	DNA-templated transcription, initiation
BF1475	COG0686	Belongs to the AlaDH PNT family
BF1478	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BF1482	COG4771	TonB-dependent receptor
BF1485	COG3345	alpha-galactosidase
BF1490	COG0488	(ABC) transporter
BF1491	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BF1492	COG3059	membrane
BF1493	COG2207	Transcriptional regulator
BF1493	COG1917	Cupin 2, conserved barrel domain protein
BF1494	COG0295	cytidine deaminase activity
BF1495	COG1705	Flagellar rod assembly protein muramidase FlgJ
BF1495	COG1388	LysM domain
BF1498	COG0577	efflux transmembrane transporter activity
BF1500	COG0577	efflux transmembrane transporter activity
BF1502	COG1136	(ABC) transporter
BF1502	COG0577	efflux transmembrane transporter activity
BF1505	COG1136	(ABC) transporter
BF1506	COG1136	(ABC) transporter
BF1506	COG0577	efflux transmembrane transporter activity
BF1508	COG1136	(ABC) transporter
BF1512	COG2205	protein histidine kinase activity
BF1515	COG2204	response regulator
BF1537	COG1088	dTDP-glucose 4,6-dehydratase activity
BF1539	COG0656	L-ascorbic acid biosynthetic process
BF1541	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BF1543	COG1215	transferase activity, transferring glycosyl groups
BF1546	COG1216	Glycosyl transferase, family 2
BF1548	COG0438	transferase activity, transferring glycosyl groups
BF1550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF1551	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF1552	COG1530	ribonuclease E activity
BF1555	COG3119	arylsulfatase activity
BF1556	COG0629	single-stranded DNA binding
BF1569	COG4206	TonB-dependent receptor
BF1575	COG5002	protein histidine kinase activity
BF1576	COG0745	RESPONSE REGULATOR receiver
BF1582	COG0488	(ABC) transporter
BF1585	COG5492	domain, Protein
BF1588	COG0436	Aminotransferase
BF1589	COG4591	ABC-type transport system involved in lipoprotein release permease component
BF1590	COG1215	transferase activity, transferring glycosyl groups
BF1591	COG0628	permease
BF1592	COG3852	Histidine kinase
BF1595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF1597	COG1136	(ABC) transporter
BF1597	COG0577	efflux transmembrane transporter activity
BF1598	COG0577	efflux transmembrane transporter activity
BF1599	COG1252	NADH dehydrogenase
BF1605	COG4771	TonB-dependent receptor
BF1608	COG1620	l-lactate permease
BF1609	COG3047	cAMP biosynthetic process
BF1609	COG2885	chlorophyll binding
BF1611	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BF1612	COG0439	Biotin carboxylase
BF1613	COG0511	ligase activity, forming carbon-carbon bonds
BF1614	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BF1621	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF1622	COG0022	dehydrogenase e1 component
BF1623	COG0716	FMN binding
BF1624	COG2264	protein methyltransferase activity
BF1635	COG0590	tRNA wobble adenosine to inosine editing
BF1641	COG0673	inositol 2-dehydrogenase activity
BF1643	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BF1651	COG0698	ribose 5-phosphate isomerase
BF1652	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BF1653	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BF1656	COG1482	cell wall glycoprotein biosynthetic process
BF1660	COG0513	Belongs to the DEAD box helicase family
BF1661	COG4221	oxidoreductase activity
BF1664	COG3250	beta-galactosidase activity
BF1666	COG0471	metal ion transport
BF1666	COG3273	potassium ion transport
BF1668	COG0175	sulfate reduction
BF1677	COG4974	Belongs to the 'phage' integrase family
BF1683	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BF1684	COG0242	peptide deformylase activity
BF1687	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BF1688	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BF1689	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BF1690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BF1692	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BF1693	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BF1696	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BF1705	COG1940	carbohydrate kinase activity
BF1706	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BF1708	COG2271	Major facilitator Superfamily
BF1709	COG2731	YhcH YjgK YiaL family protein
BF1710	COG4771	TonB-dependent receptor
BF1711	COG0702	epimerase
BF1713	COG1629	transport
BF1714	COG0702	epimerase
BF1718	COG1629	transport
BF1719	COG0702	epimerase
BF1722	COG4771	TonB-dependent receptor
BF1723	COG0702	epimerase
BF1724	COG0702	epimerase
BF1725	COG4206	TonB-dependent receptor
BF1725	COG1629	transport
BF1726	COG1629	transport
BF1726	COG4206	TonB-dependent receptor
BF1730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF1734	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF1736	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF1737	COG3537	Alpha-1,2-mannosidase
BF1738	COG3250	beta-galactosidase activity
BF1739	COG1629	transport
BF1739	COG4206	TonB-dependent receptor
BF1740	COG0702	epimerase
BF1741	COG3250	beta-galactosidase activity
BF1743	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BF1744	COG0488	(ABC) transporter
BF1745	COG1595	DNA-templated transcription, initiation
BF1750	COG0823	Involved in the tonB-independent uptake of proteins
BF1752	COG4206	TonB-dependent receptor
BF1752	COG1629	transport
BF1754	COG3537	Alpha-1,2-mannosidase
BF1755	COG3568	Endonuclease Exonuclease Phosphatase
BF1756	COG1785	Belongs to the alkaline phosphatase family
BF1760	COG2207	Transcriptional regulator
BF1760	COG1609	Transcriptional regulator
BF1761	COG2183	response to ionizing radiation
BF1776	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BF1783	COG2885	chlorophyll binding
BF1806	COG2183	response to ionizing radiation
BF1807	COG2205	protein histidine kinase activity
BF1808	COG0737	Belongs to the 5'-nucleotidase family
BF1809	COG1956	GAF domain-containing protein
BF1811	COG4771	TonB-dependent receptor
BF1814	COG0534	Mate efflux family protein
BF1817	COG0534	Mate efflux family protein
BF1819	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BF1821	COG0318	PFAM AMP-dependent synthetase and ligase
BF1822	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF1823	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BF1831	COG4750	Nucleotidyl transferase
BF1834	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BF1840	COG1216	Glycosyl transferase, family 2
BF1841	COG1216	Glycosyl transferase, family 2
BF1844	COG1086	Polysaccharide biosynthesis protein
BF1845	COG1091	dTDP-4-dehydrorhamnose reductase activity
BF1847	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF1848	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF1852	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BF1853	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BF1854	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BF1855	COG0363	glucosamine-6-phosphate deaminase activity
BF1859	COG4413	Urea transporter
BF1868	COG3279	Response regulator of the LytR AlgR family
BF1870	COG1136	(ABC) transporter
BF1870	COG0577	efflux transmembrane transporter activity
BF1871	COG1136	(ABC) transporter
BF1872	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF1877	COG4884	unkown
BF1877	COG3831	ATPase activity
BF1880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF1882	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BF1883	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BF1884	COG3250	beta-galactosidase activity
BF1890	COG1704	LemA family
BF1891	COG1595	DNA-templated transcription, initiation
BF1894	COG1629	transport
BF1894	COG4206	TonB-dependent receptor
BF1896	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF1897	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BF1897	COG2885	chlorophyll binding
BF1899	COG0697	spore germination
BF1909	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF1913	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BF1914	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF1915	COG2814	Major facilitator Superfamily
BF1916	COG4771	TonB-dependent receptor
BF1924	COG4771	TonB-dependent receptor
BF1954	COG0542	response to heat
BF1960	COG0156	8-amino-7-oxononanoate synthase activity
BF1966	COG4974	Belongs to the 'phage' integrase family
BF1977	COG4804	nuclease activity
BF1979	COG1196	nuclear chromosome segregation
BF1987	COG0582	viral genome integration into host DNA
BF1988	COG4974	Belongs to the 'phage' integrase family
BF1990	COG0488	(ABC) transporter
BF1994	COG0784	Response regulator, receiver
BF1994	COG2205	protein histidine kinase activity
BF1994	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF1994	COG2198	Histidine kinase
BF1998	COG0438	transferase activity, transferring glycosyl groups
BF2001	COG2244	polysaccharide biosynthetic process
BF2002	COG0438	transferase activity, transferring glycosyl groups
BF2005	COG1215	transferase activity, transferring glycosyl groups
BF2011	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BF2012	COG1805	sodium ion transport
BF2013	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BF2018	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BF2019	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BF2021	COG0545	Peptidyl-prolyl cis-trans isomerase
BF2022	COG1739	Uncharacterized protein family UPF0029
BF2024	COG0778	Nitroreductase
BF2026	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF2032	COG2217	Heavy metal translocating P-type atpase
BF2040	COG3852	Histidine kinase
BF2041	COG2204	response regulator
BF2046	COG1136	(ABC) transporter
BF2049	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF2050	COG1755	Isoprenylcysteine carboxyl methyltransferase
BF2053	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BF2056	COG1678	Uncharacterized ACR, COG1678
BF2069	COG0667	Aldo Keto reductase
BF2073	COG0667	Aldo Keto reductase
BF2075	COG0656	L-ascorbic acid biosynthetic process
BF2077	COG0656	L-ascorbic acid biosynthetic process
BF2080	COG0534	Mate efflux family protein
BF2081	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BF2085	COG2311	Membrane
BF2086	COG0667	Aldo Keto reductase
BF2102	COG4771	TonB-dependent receptor
BF2109	COG1309	transcriptional regulator
BF2112	COG1132	(ABC) transporter
BF2114	COG2205	protein histidine kinase activity
BF2114	COG4999	Histidine kinase
BF2114	COG3850	Histidine kinase
BF2114	COG3437	response regulator, receiver
BF2117	COG1522	sequence-specific DNA binding
BF2121	COG3969	phosphoadenosine phosphosulfate
BF2122	COG1475	DNA binding
BF2132	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF2133	COG0745	RESPONSE REGULATOR receiver
BF2136	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF2138	COG1629	transport
BF2138	COG4206	TonB-dependent receptor
BF2140	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BF2144	COG1022	Amp-dependent synthetase and ligase
BF2145	COG3263	regulation of cellular component size
BF2154	COG1136	(ABC) transporter
BF2154	COG0577	efflux transmembrane transporter activity
BF2156	COG1136	(ABC) transporter
BF2156	COG0577	efflux transmembrane transporter activity
BF2159	COG0534	Mate efflux family protein
BF2160	COG1011	Hydrolase
BF2161	COG0167	dihydroorotate dehydrogenase activity
BF2163	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BF2166	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BF2172	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BF2174	COG0356	it plays a direct role in the translocation of protons across the membrane
BF2175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BF2176	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BF2177	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BF2178	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BF2180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BF2181	COG3118	belongs to the thioredoxin family
BF2185	COG0745	RESPONSE REGULATOR receiver
BF2186	COG5002	protein histidine kinase activity
BF2194	COG1120	ATPase activity
BF2195	COG1091	dTDP-4-dehydrorhamnose reductase activity
BF2201	COG2205	protein histidine kinase activity
BF2202	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BF2204	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BF2207	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BF2208	COG0540	Belongs to the ATCase OTCase family
BF2210	COG2431	L-lysine efflux transmembrane transporter activity
BF2216	COG2837	iron assimilation
BF2219	COG1629	transport
BF2219	COG4206	TonB-dependent receptor
BF2223	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BF2227	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BF2231	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BF2232	COG2205	protein histidine kinase activity
BF2239	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BF2240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF2243	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BF2245	COG0673	inositol 2-dehydrogenase activity
BF2248	COG2223	nitrite transmembrane transporter activity
BF2252	COG0671	phosphoesterase, PA-phosphatase related
BF2256	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BF2257	COG0045	succinate-CoA ligase (ADP-forming) activity
BF2258	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BF2259	COG0351	phosphomethylpyrimidine kinase
BF2261	COG1070	Carbohydrate kinase
BF2263	COG2814	Major facilitator Superfamily
BF2263	COG0477	Major facilitator Superfamily
BF2265	COG3153	acetyltransferase
BF2265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BF2266	COG0450	alkyl hydroperoxide reductase
BF2267	COG0724	RNA recognition motif
BF2268	COG1858	cytochrome C peroxidase
BF2269	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BF2277	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BF2280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BF2291	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BF2293	COG1904	glucuronate isomerase
BF2299	COG0513	Belongs to the DEAD box helicase family
BF2300	COG0560	Phosphoserine phosphatase
BF2300	COG3830	Belongs to the UPF0237 family
BF2303	COG0343	queuine tRNA-ribosyltransferase activity
BF2304	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BF2364	COG2205	protein histidine kinase activity
BF2365	COG2204	response regulator
BF2375	COG0577	efflux transmembrane transporter activity
BF2375	COG1136	(ABC) transporter
BF2377	COG0156	8-amino-7-oxononanoate synthase activity
BF2378	COG1597	lipid kinase activity
BF2384	COG1136	(ABC) transporter
BF2384	COG0577	efflux transmembrane transporter activity
BF2389	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BF2395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BF2399	COG0543	2 iron, 2 sulfur cluster binding
BF2400	COG0167	dihydroorotate dehydrogenase activity
BF2402	COG0336	Belongs to the RNA methyltransferase TrmD family
BF2404	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BF2406	COG2315	Protein conserved in bacteria
BF2410	COG0542	response to heat
BF2419	COG2304	oxidoreductase activity
BF2422	COG0714	Associated with various cellular activities
BF2423	COG1652	LysM domain
BF2425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BF2426	COG0552	protein localization to endoplasmic reticulum
BF2427.1	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BF2429	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BF2431	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BF2434	COG0442	prolyl-tRNA aminoacylation
BF2437	COG0793	Belongs to the peptidase S41A family
BF2437	COG4946	Tricorn protease homolog
BF2470	COG0863	Belongs to the N(4) N(6)-methyltransferase family
BF2487	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BF2489	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BF2491	COG1492	cobalamin metabolic process
BF2502	COG2096	Adenosyltransferase
BF2503	COG1797	cobyrinic acid a,c-diamide synthase activity
BF2506	COG2966	Psort location CytoplasmicMembrane, score
BF2510	COG4771	TonB-dependent receptor
BF2512	COG4774	siderophore transport
BF2514	COG1429	ligase activity, forming nitrogen-metal bonds
BF2521	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BF2530	COG2022	thiamine diphosphate biosynthetic process
BF2531	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BF2535	COG0352	thiamine-phosphate diphosphorylase activity
BF2538	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BF2538	COG0574	Belongs to the PEP-utilizing enzyme family
BF2539	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BF2540	COG0564	pseudouridine synthase activity
BF2543	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BF2544	COG1518	maintenance of DNA repeat elements
BF2551	COG0024	Methionine aminopeptidase
BF2556	COG0481	GTPase activity
BF2560	COG0708	Exodeoxyribonuclease III
BF2561	COG1914	H( )-stimulated, divalent metal cation uptake system
BF2564	COG0217	transcriptional regulatory protein
BF2566	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF2567	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF2569	COG1091	dTDP-4-dehydrorhamnose reductase activity
BF2570	COG1086	Polysaccharide biosynthesis protein
BF2571	COG1216	Glycosyl transferase, family 2
BF2571	COG1442	glycosyl transferase family 8
BF2572	COG1216	Glycosyl transferase, family 2
BF2572	COG0463	Glycosyl transferase, family 2
BF2576	COG1454	alcohol dehydrogenase
BF2579	COG3475	LICD family
BF2582	COG2244	polysaccharide biosynthetic process
BF2588	COG0305	Participates in initiation and elongation during chromosome replication
BF2592	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BF2593	COG4657	Part of a membrane complex involved in electron transport
BF2594	COG4660	Part of a membrane complex involved in electron transport
BF2595	COG4659	FMN binding
BF2596	COG4658	electron transport chain
BF2597	COG4656	Part of a membrane complex involved in electron transport
BF2602	COG0504	CTP synthase activity
BF2604	COG0534	Mate efflux family protein
BF2605	COG1506	peptidase
BF2605	COG0823	Involved in the tonB-independent uptake of proteins
BF2608	COG1695	Transcriptional regulator
BF2611	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BF2613	COG3942	CHAP domain
BF2613	COG1388	LysM domain
BF2619	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BF2622	COG2949	membrane
BF2624	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BF2626	COG4999	Histidine kinase
BF2626	COG3850	Histidine kinase
BF2626	COG3437	response regulator, receiver
BF2626	COG2205	protein histidine kinase activity
BF2628	COG0842	Transport permease protein
BF2629	COG1131	(ABC) transporter
BF2635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BF2636	COG0505	Belongs to the CarA family
BF2638	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BF2639	COG0367	asparagine synthase
BF2645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BF2647	COG1979	alcohol dehydrogenase
BF2650	COG0133	tryptophan synthase activity
BF2651	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BF2652	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BF2652	COG0512	Glutamine amidotransferase of anthranilate synthase
BF2654	COG0134	indole-3-glycerol-phosphate synthase activity
BF2655	COG0135	phosphoribosylanthranilate isomerase activity
BF2656	COG0159	tryptophan synthase activity
BF2658	COG0252	asparaginase activity
BF2661	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF2663	COG0110	maltose O-acetyltransferase activity
BF2664	COG2197	response regulator
BF2666	COG0138	bifunctional purine biosynthesis protein purh
BF2667	COG0716	FMN binding
BF2673	COG1858	cytochrome C peroxidase
BF2675	COG4771	TonB-dependent receptor
BF2678	COG2814	Major facilitator Superfamily
BF2679	COG1566	PFAM secretion protein HlyD family protein
BF2688	COG4771	TonB-dependent receptor
BF2693	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF2694	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF2697	COG2966	Psort location CytoplasmicMembrane, score
BF2698	COG3610	response to peptide
BF2701	COG1609	Transcriptional regulator
BF2703	COG1733	regulation of RNA biosynthetic process
BF2705	COG2205	protein histidine kinase activity
BF2705	COG2198	Histidine kinase
BF2705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF2705	COG0784	Response regulator, receiver
BF2710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BF2711	COG1690	Belongs to the RtcB family
BF2719	COG0724	RNA recognition motif
BF2721	COG1177	transmembrane transport
BF2722	COG1176	ABC-type spermidine putrescine transport system, permease component I
BF2724	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF2726	COG0058	SHG alpha-glucan phosphorylase activity
BF2728	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BF2732	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BF2736	COG0745	RESPONSE REGULATOR receiver
BF2737	COG5002	protein histidine kinase activity
BF2742	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BF2744	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF2746	COG4948	Mandelate Racemase Muconate Lactonizing
BF2749	COG1295	ribonuclease BN
BF2751	COG0778	Nitroreductase
BF2753	COG0704	Plays a role in the regulation of phosphate uptake
BF2754	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BF2755	COG0581	inorganic phosphate transmembrane transporter activity
BF2756	COG0573	inorganic phosphate transmembrane transporter activity
BF2758	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BF2763	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BF2770	COG3023	N-Acetylmuramoyl-L-alanine amidase
BF2779	COG1216	Glycosyl transferase, family 2
BF2779	COG0463	Glycosyl transferase, family 2
BF2788	COG4974	Belongs to the 'phage' integrase family
BF2822	COG1475	DNA binding
BF2826	COG1192	Involved in chromosome partitioning
BF2835	COG0542	response to heat
BF2847	COG3209	COG3209 Rhs family protein
BF2850	COG3209	COG3209 Rhs family protein
BF2852	COG3209	COG3209 Rhs family protein
BF2872	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BF2873	COG1196	nuclear chromosome segregation
BF2873	COG0739	heme binding
BF2873	COG0741	lytic transglycosylase activity
BF2885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BF2923	COG0438	transferase activity, transferring glycosyl groups
BF2926	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BF2936	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BF2949	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BF2950	COG0167	dihydroorotate dehydrogenase activity
BF2963	COG5002	protein histidine kinase activity
BF2966	COG2172	sigma factor antagonist activity
BF2968	COG2208	phosphoserine phosphatase activity
BF2973	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BF2977	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BF2978	COG0497	DNA recombination
BF2980	COG2176	DNA-directed DNA polymerase activity
BF2980	COG5002	protein histidine kinase activity
BF2981	COG0592	DNA-directed DNA polymerase activity
BF2984	COG0321	lipoyl(octanoyl) transferase activity
BF2984	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BF2987	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF2988	COG0156	8-amino-7-oxononanoate synthase activity
BF3003	COG4974	Belongs to the 'phage' integrase family
BF3004	COG4974	Belongs to the 'phage' integrase family
BF3019	COG1192	Involved in chromosome partitioning
BF3026	COG1120	ATPase activity
BF3027	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF3049	COG0019	diaminopimelate decarboxylase activity
BF3050	COG0527	aspartate kinase activity
BF3051	COG2884	Cell division ATP-binding protein ftsE
BF3052	COG0140	phosphoribosyl-ATP diphosphatase activity
BF3052	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BF3056	COG3586	endonuclease activity
BF3064	COG1472	Belongs to the glycosyl hydrolase 3 family
BF3065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BF3067	COG5012	cobalamin binding
BF3069	COG1472	Belongs to the glycosyl hydrolase 3 family
BF3070	COG0702	epimerase
BF3071	COG4771	TonB-dependent receptor
BF3075	COG0693	protein deglycase activity
BF3077	COG0494	nUDIX hydrolase
BF3091	COG4977	sequence-specific DNA binding
BF3091	COG1917	Cupin 2, conserved barrel domain protein
BF3092	COG2814	Major facilitator Superfamily
BF3093	COG1028	Short-chain dehydrogenase reductase Sdr
BF3094	COG2207	Transcriptional regulator
BF3097	COG1090	epimerase
BF3103	COG0561	phosphatase activity
BF3104	COG1629	transport
BF3104	COG4206	TonB-dependent receptor
BF3114	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BF3116	COG0363	glucosamine-6-phosphate deaminase activity
BF3126	COG1032	radical SAM domain protein
BF3127	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BF3128	COG0463	Glycosyl transferase, family 2
BF3129	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BF3131	COG0646	methionine synthase
BF3131	COG1410	methionine synthase
BF3143	COG1408	metallophosphoesterase
BF3144	COG1132	(ABC) transporter
BF3145	COG1132	(ABC) transporter
BF3147	COG0420	3'-5' exonuclease activity
BF3151	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF3152	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF3154	COG0681	Belongs to the peptidase S26 family
BF3170	COG0641	radical SAM
BF3171	COG3591	Belongs to the peptidase S1B family
BF3172	COG3591	Belongs to the peptidase S1B family
BF3178	COG1773	rubredoxin
BF3178	COG1592	Rubrerythrin
BF3180	COG3152	Membrane
BF3181	COG0339	signal peptide processing
BF3182	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BF3182	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BF3184	COG4206	TonB-dependent receptor
BF3184	COG1629	transport
BF3187	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BF3187	COG0131	Imidazoleglycerol-phosphate dehydratase
BF3190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BF3192	COG1741	Belongs to the pirin family
BF3193	COG4232	protein-disulfide reductase activity
BF3195	COG0572	uridine kinase
BF3197	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF3199	COG0646	methionine synthase
BF3199	COG1410	methionine synthase
BF3200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BF3208	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF3210	COG1295	ribonuclease BN
BF3215	COG2202	Pas domain
BF3215	COG2205	protein histidine kinase activity
BF3216	COG0534	Mate efflux family protein
BF3217	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BF3218	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF3219	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BF3220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF3231	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BF3239	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF3241	COG0668	transmembrane transport
BF3244	COG3250	beta-galactosidase activity
BF3246	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF3247	COG3119	arylsulfatase activity
BF3248	COG3119	arylsulfatase activity
BF3249	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF3250	COG2205	protein histidine kinase activity
BF3250	COG0745	RESPONSE REGULATOR receiver
BF3250	COG3292	Two component regulator propeller
BF3251	COG1830	Aldolase
BF3252	COG0588	phosphoglycerate mutase activity
BF3254	COG1119	ATPase activity
BF3255	COG3119	arylsulfatase activity
BF3256	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF3258	COG1629	transport
BF3258	COG4206	TonB-dependent receptor
BF3260	COG1595	DNA-templated transcription, initiation
BF3261	COG1523	belongs to the glycosyl hydrolase 13 family
BF3262	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BF3266	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BF3268	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BF3269	COG0126	phosphoglycerate kinase activity
BF3272	COG2311	Membrane
BF3282	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BF3285	COG0778	Nitroreductase
BF3286	COG0288	reversible hydration of carbon dioxide
BF3289	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BF3291	COG5016	pyruvate
BF3291	COG0511	ligase activity, forming carbon-carbon bonds
BF3292	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BF3295	COG0366	Alpha amylase catalytic
BF3299	COG0191	fructose-bisphosphate aldolase activity
BF3301	COG0254	rRNA binding
BF3306	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BF3307	COG4206	TonB-dependent receptor
BF3307	COG1629	transport
BF3308	COG1609	Transcriptional regulator
BF3310	COG1554	hydrolase, family 65, central catalytic
BF3311	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF3315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BF3315	COG0047	phosphoribosylformylglycinamidine synthase activity
BF3316	COG0745	RESPONSE REGULATOR receiver
BF3316	COG3292	Two component regulator propeller
BF3316	COG2205	protein histidine kinase activity
BF3319	COG1649	PFAM Uncharacterised BCR, COG1649
BF3323	COG1966	Carbon starvation protein
BF3325	COG1649	PFAM Uncharacterised BCR, COG1649
BF3326	COG2205	protein histidine kinase activity
BF3326	COG0784	Response regulator, receiver
BF3334	COG2113	Glycine betaine
BF3335	COG4176	ABC-type proline glycine betaine transport system permease component
BF3339	COG2205	protein histidine kinase activity
BF3339	COG3292	Two component regulator propeller
BF3339	COG0745	RESPONSE REGULATOR receiver
BF3340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BF3340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BF3342	COG1621	beta-fructofuranosidase activity
BF3350	COG0738	Major facilitator superfamily
BF3353	COG1752	Esterase of the alpha-beta hydrolase superfamily
BF3354	COG0475	glutathione-regulated potassium exporter activity
BF3359	COG3015	lipoprotein NlpE involved in copper resistance
BF3363	COG4977	sequence-specific DNA binding
BF3363	COG1917	Cupin 2, conserved barrel domain protein
BF3369	COG4771	TonB-dependent receptor
BF3370	COG0702	epimerase
BF3373	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BF3377	COG0484	heat shock protein binding
BF3379	COG2194	sulfuric ester hydrolase activity
BF3383	COG0492	ferredoxin-NADP+ reductase activity
BF3383	COG3118	belongs to the thioredoxin family
BF3389	COG0028	Belongs to the TPP enzyme family
BF3395	COG0459	protein refolding
BF3396	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BF3404	COG2326	polyphosphate kinase activity
BF3413	COG3537	Alpha-1,2-mannosidase
BF3415	COG1506	peptidase
BF3415	COG0823	Involved in the tonB-independent uptake of proteins
BF3421	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BF3430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF3432	COG0671	phosphoesterase, PA-phosphatase related
BF3436	COG0702	epimerase
BF3437	COG4771	TonB-dependent receptor
BF3443	COG0463	Glycosyl transferase, family 2
BF3446	COG0066	3-isopropylmalate dehydratase activity
BF3447	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BF3448	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BF3451	COG0616	signal peptide processing
BF3453	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BF3454	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BF3464	COG0582	viral genome integration into host DNA
BF3480	COG2207	Transcriptional regulator
BF3480	COG3708	Transcriptional regulator
BF3487	COG0546	phosphoglycolate phosphatase activity
BF3490	COG2207	Transcriptional regulator
BF3491	COG0745	RESPONSE REGULATOR receiver
BF3491	COG3292	Two component regulator propeller
BF3491	COG2205	protein histidine kinase activity
BF3492	COG4948	Mandelate Racemase Muconate Lactonizing
BF3496	COG0702	epimerase
BF3497	COG1629	transport
BF3497	COG4206	TonB-dependent receptor
BF3504	COG1917	Cupin 2, conserved barrel domain protein
BF3504	COG2207	Transcriptional regulator
BF3507	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BF3509	COG3011	Protein conserved in bacteria
BF3511	COG1028	Short-chain dehydrogenase reductase Sdr
BF3524	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BF3527	COG4651	solute:proton antiporter activity
BF3527	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BF3529	COG0439	Biotin carboxylase
BF3530	COG0511	ligase activity, forming carbon-carbon bonds
BF3530	COG5016	pyruvate
BF3531	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BF3532	COG1335	isochorismatase
BF3536	COG0516	GMP reductase activity
BF3536	COG0517	IMP dehydrogenase activity
BF3545	COG2873	o-acetylhomoserine
BF3561	COG2217	Heavy metal translocating P-type atpase
BF3563	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF3565	COG0741	lytic transglycosylase activity
BF3565	COG1388	LysM domain
BF3566	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BF3567	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BF3567	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BF3569	COG1285	pathogenesis
BF3573	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF3573	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF3576	COG1115	amino acid carrier protein
BF3578	COG1509	lysine 2,3-aminomutase activity
BF3579	COG2233	PERMEase
BF3583	COG1393	Belongs to the ArsC family
BF3584	COG4206	TonB-dependent receptor
BF3584	COG1629	transport
BF3587	COG4589	Belongs to the CDS family
BF3589	COG2304	oxidoreductase activity
BF3591	COG0351	phosphomethylpyrimidine kinase
BF3593	COG1139	Iron-sulfur cluster binding protein
BF3594	COG0247	lactate metabolic process
BF3595	COG0602	queuosine metabolic process
BF3597	COG2832	Protein of unknown function (DUF454)
BF3598	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BF3602	COG1418	mRNA catabolic process
BF3607	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BF3611	COG4771	TonB-dependent receptor
BF3640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BF3640	COG0517	IMP dehydrogenase activity
BF3640	COG0617	tRNA 3'-terminal CCA addition
BF3643	COG1278	Cold shock
BF3647	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF3648	COG1216	Glycosyl transferase, family 2
BF3649	COG0438	transferase activity, transferring glycosyl groups
BF3654	COG1216	Glycosyl transferase, family 2
BF3656	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BF3657	COG1216	Glycosyl transferase, family 2
BF3660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BF3665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF3676	COG0776	regulation of translation
BF3677	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BF3689	COG0632	four-way junction helicase activity
BF3690	COG0673	inositol 2-dehydrogenase activity
BF3691	COG1272	protein, Hemolysin III
BF3692	COG1328	CTP reductase activity
BF3693	COG0602	queuosine metabolic process
BF3694	COG2814	Major facilitator Superfamily
BF3696	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BF3698	COG0750	zinc metalloprotease
BF3701	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BF3702	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BF3704	COG1214	PFAM Peptidase M22, glycoprotease
BF3707	COG0194	GDP metabolic process
BF3708	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BF3709	COG1408	metallophosphoesterase
BF3710	COG1575	Belongs to the MenA family. Type 1 subfamily
BF3711	COG1088	dTDP-glucose 4,6-dehydratase activity
BF3712	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BF3714	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BF3716	COG2204	response regulator
BF3717	COG0488	(ABC) transporter
BF3736	COG1522	sequence-specific DNA binding
BF3742	COG0811	peptide transport
BF3743	COG0084	hydrolase, TatD family'
BF3746	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BF3747	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BF3748	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BF3749	COG0205	6-phosphofructokinase activity
BF3753	COG0372	Belongs to the citrate synthase family
BF3754	COG0538	isocitrate dehydrogenase activity
BF3756	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BF3758	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BF3768	COG2885	chlorophyll binding
BF3772	COG3681	Belongs to the UPF0597 family
BF3780	COG0702	epimerase
BF3781	COG4771	TonB-dependent receptor
BF3784	COG0702	epimerase
BF3785	COG1629	transport
BF3785	COG4206	TonB-dependent receptor
BF3787	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF3787	COG3291	Pkd domain containing protein
BF3789	COG4771	TonB-dependent receptor
BF3800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BF3800	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BF3801	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BF3807	COG1752	Esterase of the alpha-beta hydrolase superfamily
BF3809	COG0534	Mate efflux family protein
BF3811	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BF3812	COG0166	Belongs to the GPI family
BF3814	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BF3815	COG2502	aspartate--ammonia ligase
BF3816	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BF3819	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF3823	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF3825	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BF3828	COG1640	4-alpha-glucanotransferase
BF3830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BF3831	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF3851	COG2207	Transcriptional regulator
BF3856	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BF3857	COG1022	Amp-dependent synthetase and ligase
BF3861	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BF3862	COG0360	Binds together with S18 to 16S ribosomal RNA
BF3867	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BF3869	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF3873	COG4771	TonB-dependent receptor
BF3876	COG2431	L-lysine efflux transmembrane transporter activity
BF3884	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BF3885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BF3886	COG0386	Belongs to the glutathione peroxidase family
BF3890	COG3275	phosphorelay sensor kinase activity
BF3891	COG3279	Response regulator of the LytR AlgR family
BF3895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BF3898	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BF3900	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BF3901	COG0658	competence protein
BF3902	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BF3903	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BF3905	COG0009	L-threonylcarbamoyladenylate synthase
BF3911	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF3912	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF3923	COG2244	polysaccharide biosynthetic process
BF3930	COG2818	Glycosylase
BF3932	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BF3932	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BF3933	COG0514	ATP-dependent DNA helicase (RecQ)
BF3935	COG2271	Major facilitator Superfamily
BF3938	COG0702	epimerase
BF3939	COG4771	TonB-dependent receptor
BF3940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BF3941	COG2186	Transcriptional regulator
BF3943	COG0436	Aminotransferase
BF3944	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BF3947	COG0358	DNA primase activity
BF3948	COG3119	arylsulfatase activity
BF3951	COG4206	TonB-dependent receptor
BF3951	COG1629	transport
BF3954	COG0302	gtp cyclohydrolase
BF3956	COG0149	triose-phosphate isomerase activity
BF3959	COG0739	heme binding
BF3960	COG0105	UTP biosynthetic process
BF3961	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BF3966	COG0811	peptide transport
BF3971	COG1629	transport
BF3978	COG0039	L-malate dehydrogenase activity
BF3985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BF3988	COG4948	Mandelate Racemase Muconate Lactonizing
BF3992	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BF3993	COG3118	belongs to the thioredoxin family
BF3994	COG0489	protein tyrosine kinase activity
BF3997	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF3998	COG1722	exodeoxyribonuclease VII activity
BF3999	COG1570	exodeoxyribonuclease VII activity
BF4007	COG0179	Fumarylacetoacetate (FAA) hydrolase
BF4008	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BF4010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BF4011	COG0052	Belongs to the universal ribosomal protein uS2 family
BF4012	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BF4013	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BF4017	COG1187	pseudouridine synthase activity
BF4020	COG0110	maltose O-acetyltransferase activity
BF4022	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF4035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BF4042	COG1442	glycosyl transferase family 8
BF4042	COG1216	Glycosyl transferase, family 2
BF4047	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BF4053	COG0297	glycogen (starch) synthase activity
BF4067	COG4680	protein conserved in bacteria
BF4069	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BF4072	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BF4075	COG0517	IMP dehydrogenase activity
BF4075	COG0516	GMP reductase activity
BF4076	COG0514	ATP-dependent DNA helicase (RecQ)
BF4077	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BF4082	COG0724	RNA recognition motif
BF4084	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BF4085	COG1127	ABC transporter
BF4086	COG2197	response regulator
BF4087	COG1160	GTP binding
BF4088	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BF4089	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF4092	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BF4093	COG0470	DNA polymerase III
BF4094	COG1774	PSP1 C-terminal conserved region
BF4096	COG0772	Belongs to the SEDS family
BF4099	COG1792	Involved in formation and maintenance of cell shape
BF4101	COG0138	bifunctional purine biosynthesis protein purh
BF4102	COG3590	peptidase
BF4103	COG0488	(ABC) transporter
BF4110	COG0784	Response regulator, receiver
BF4110	COG2205	protein histidine kinase activity
BF4111	COG0534	Mate efflux family protein
BF4112	COG0612	Peptidase, M16
BF4117	COG0564	pseudouridine synthase activity
BF4124	COG2312	Erythromycin esterase
BF4128	COG1131	(ABC) transporter
BF4136	COG1696	Membrane protein involved in D-alanine export
BF4144	COG2986	histidine ammonia-lyase
BF4148	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BF4154	COG0203	ribosomal protein L17
BF4155	COG0202	RNA polymerase activity
BF4156	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BF4157	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BF4158	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BF4158.1	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BF4159	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BF4162	COG0200	Binds to the 23S rRNA
BF4163	COG1841	ribosomal large subunit assembly
BF4164	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BF4165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BF4166	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BF4167	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BF4168	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BF4169	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BF4170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BF4171	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BF4172	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BF4173	COG0255	Belongs to the universal ribosomal protein uL29 family
BF4174	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BF4175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BF4177	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BF4178	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BF4179	COG0089	rRNA binding
BF4180	COG0088	Forms part of the polypeptide exit tunnel
BF4181	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BF4182	COG0051	transcription antitermination factor activity, RNA binding
BF4183	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BF4184	COG0049	tRNA binding
BF4185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BF4192	COG0085	RNA polymerase activity
BF4193	COG0222	ribosome binding
BF4194	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BF4195	COG0081	regulation of translation
BF4196	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BF4200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BF4201	COG4974	Belongs to the 'phage' integrase family
BF4202	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BF4204	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BF4206	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BF4207	COG1480	7TM receptor with intracellular HD hydrolase
BF4208	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BF4210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BF4213	COG1027	Aspartate ammonia-lyase
BF4214	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BF4215	COG0252	asparaginase activity
BF4221	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BF4223	COG4804	nuclease activity
BF4228	COG0582	viral genome integration into host DNA
BF4234	COG2205	protein histidine kinase activity
BF4234	COG3292	Two component regulator propeller
BF4234	COG0745	RESPONSE REGULATOR receiver
BF4245	COG2271	Major facilitator Superfamily
BF4247	COG4771	TonB-dependent receptor
BF4248	COG0702	epimerase
BF4250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BF4254	COG4771	TonB-dependent receptor
BF4276	COG2096	Adenosyltransferase
BF4291	COG0657	acetylesterase activity
BF4291	COG2755	lipolytic protein G-D-S-L family
BF4293	COG3275	phosphorelay sensor kinase activity
BF4294	COG3279	Response regulator of the LytR AlgR family
BF4297	COG4206	TonB-dependent receptor
BF4301	COG2197	response regulator
BF4305	COG0662	Cupin 2, conserved barrel domain protein
BF4305	COG2207	Transcriptional regulator
BF4306	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BF4313	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF4324	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BF4326	COG1185	polyribonucleotide nucleotidyltransferase activity
BF4329	COG4771	TonB-dependent receptor
BF4336	COG3426	butyrate kinase activity
BF4337	COG0280	phosphate acetyltransferase
BF4339	COG1619	proteins homologs of microcin C7 resistance protein MccF
BF4340	COG2234	aminopeptidase activity
BF4341	COG2166	iron-sulfur cluster assembly
BF4342	COG3655	Transcriptional regulator
BF4344	COG1266	CAAX protease self-immunity
BF4346	COG0196	riboflavin kinase activity
BF4347	COG1011	Hydrolase
BF4348	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BF4350	COG1773	rubredoxin
BF4351	COG1283	sodium-dependent phosphate transmembrane transporter activity
BF4353	COG2205	protein histidine kinase activity
BF4360	COG0006	proline dipeptidase activity
BF4364	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BF4369	COG0702	epimerase
BF4370	COG4771	TonB-dependent receptor
BF4374	COG0793	Belongs to the peptidase S41A family
BF4375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BF4380	COG4771	TonB-dependent receptor
BF4382	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BF4383	COG1882	Formate acetyltransferase
BF4384	COG2814	Major facilitator Superfamily
BF4384	COG0477	Major facilitator Superfamily
BF4388	COG1040	competence protein
BF4389	COG0483	inositol monophosphate 1-phosphatase activity
BF4391	COG3345	alpha-galactosidase
BF4396	COG3475	LICD family
BF4397	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BF4399	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BF4403	COG1442	glycosyl transferase family 8
BF4428	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BF4429	COG0776	regulation of translation
BF4437	COG2207	Transcriptional regulator
BF4437	COG1609	Transcriptional regulator
BF4440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BF4440	COG0674	pyruvate-flavodoxin oxidoreductase activity
BF4441	COG1013	pyruvate-flavodoxin oxidoreductase activity
BF4444	COG0584	glycerophosphoryl diester phosphodiesterase
BF4445	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BF4446	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BF4448	COG1629	transport
BF4451	COG1629	transport
BF4460	COG1629	transport
BF4463	COG1217	gtp-binding protein TYPA
BF4464	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BF4466	COG0318	PFAM AMP-dependent synthetase and ligase
BF4467	COG0784	Response regulator, receiver
BF4467	COG2205	protein histidine kinase activity
BF4467	COG5002	protein histidine kinase activity
BF4472	COG3119	arylsulfatase activity
BF4474	COG1629	transport
BF4474	COG4206	TonB-dependent receptor
BF4478	COG4591	ABC-type transport system involved in lipoprotein release permease component
BF4479	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BF4483	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BF4484	COG4974	Belongs to the 'phage' integrase family
BF4486	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF4487	COG0606	chelatase, subunit chli
BF4491	COG2205	protein histidine kinase activity
BF4491	COG0745	RESPONSE REGULATOR receiver
BF4491	COG3292	Two component regulator propeller
BF4505	COG0438	transferase activity, transferring glycosyl groups
BF4510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BF4511	COG0438	transferase activity, transferring glycosyl groups
BF4513	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BF4514	COG0545	Peptidyl-prolyl cis-trans isomerase
BF4515	COG0545	Peptidyl-prolyl cis-trans isomerase
BF4516	COG1522	sequence-specific DNA binding
BF4519	COG3275	phosphorelay sensor kinase activity
BF4527	COG1629	transport
BF4527	COG4206	TonB-dependent receptor
BF4529	COG2814	Major facilitator Superfamily
BF4536	COG3292	Two component regulator propeller
BF4536	COG2205	protein histidine kinase activity
BF4536	COG0745	RESPONSE REGULATOR receiver
BF4537	COG1621	beta-fructofuranosidase activity
BF4546	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BF4547	COG0793	Belongs to the peptidase S41A family
BF4547	COG3409	Peptidoglycan-binding domain 1 protein
BF4552	COG1053	succinate dehydrogenase
BF4553	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BF4556	COG4771	TonB-dependent receptor
BF4562	COG0758	DNA mediated transformation
BF4562	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BF4564	COG0826	peptidase U32
BF4566	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BF4569	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BF4570	COG0557	exoribonuclease II activity
BF4576	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF4579	COG0012	GTP binding
BF4580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BF4581	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BF4583	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BF4587	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF4590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate