locus-tag	class	description
C3V43_RS00010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3V43_RS00055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3V43_RS00090	COG0166	Belongs to the GPI family
C3V43_RS00095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3V43_RS00100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3V43_RS00105	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3V43_RS00115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3V43_RS00120	COG0778	Nitroreductase
C3V43_RS00135	COG1640	4-alpha-glucanotransferase
C3V43_RS00140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3V43_RS00155	COG3385	transposase activity
C3V43_RS00190	COG1803	Methylglyoxal synthase
C3V43_RS00205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3V43_RS00210	COG0318	PFAM AMP-dependent synthetase and ligase
C3V43_RS00220	COG0359	binds to the 23S rRNA
C3V43_RS00225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3V43_RS00230	COG0360	Binds together with S18 to 16S ribosomal RNA
C3V43_RS00255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3V43_RS00260	COG1312	Catalyzes the dehydration of D-mannonate
C3V43_RS00275	COG1629	transport
C3V43_RS00275	COG4206	TonB-dependent receptor
C3V43_RS00310	COG3119	arylsulfatase activity
C3V43_RS00320	COG3292	Two component regulator propeller
C3V43_RS00320	COG0745	RESPONSE REGULATOR receiver
C3V43_RS00320	COG3292	Two component regulator propeller
C3V43_RS00320	COG2205	protein histidine kinase activity
C3V43_RS00320	COG0745	RESPONSE REGULATOR receiver
C3V43_RS00320	COG2205	protein histidine kinase activity
C3V43_RS00335	COG1629	transport
C3V43_RS00340	COG0702	epimerase
C3V43_RS00345	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C3V43_RS00355	COG4771	TonB-dependent receptor
C3V43_RS00365	COG3119	arylsulfatase activity
C3V43_RS00375	COG1940	carbohydrate kinase activity
C3V43_RS00395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3V43_RS00410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3V43_RS00415	COG0742	ribosomal rna small subunit methyltransferase
C3V43_RS00445	COG0739	heme binding
C3V43_RS00495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3V43_RS00500	COG1388	LysM domain
C3V43_RS00500	COG1705	Flagellar rod assembly protein muramidase FlgJ
C3V43_RS00510	COG1475	DNA binding
C3V43_RS00515	COG1192	Involved in chromosome partitioning
C3V43_RS00525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C3V43_RS00530	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3V43_RS00545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3V43_RS00550	COG0799	negative regulation of ribosome biogenesis
C3V43_RS00565	COG2271	Major facilitator Superfamily
C3V43_RS00570	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C3V43_RS00575	COG3775	system Galactitol-specific IIC component
C3V43_RS00580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C3V43_RS00590	COG2755	lipolytic protein G-D-S-L family
C3V43_RS00595	COG3458	cephalosporin-C deacetylase activity
C3V43_RS00600	COG0673	inositol 2-dehydrogenase activity
C3V43_RS00630	COG2205	protein histidine kinase activity
C3V43_RS00630	COG3292	Two component regulator propeller
C3V43_RS00630	COG0745	RESPONSE REGULATOR receiver
C3V43_RS00640	COG1629	transport
C3V43_RS00640	COG4206	TonB-dependent receptor
C3V43_RS00645	COG3292	Two component regulator propeller
C3V43_RS00645	COG2205	protein histidine kinase activity
C3V43_RS00645	COG0745	RESPONSE REGULATOR receiver
C3V43_RS00655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3V43_RS00660	COG2239	Acts as a magnesium transporter
C3V43_RS00665	COG1196	nuclear chromosome segregation
C3V43_RS00670	COG0009	L-threonylcarbamoyladenylate synthase
C3V43_RS00675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3V43_RS00680	COG0561	phosphatase activity
C3V43_RS00695	COG1073	alpha beta
C3V43_RS00710	COG1674	ftsk spoiiie
C3V43_RS00720	COG0492	ferredoxin-NADP+ reductase activity
C3V43_RS00750	COG3547	Transposase (IS116 IS110 IS902 family)
C3V43_RS00765	COG3385	transposase activity
C3V43_RS00780	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C3V43_RS00825	COG1234	tRNA 3'-trailer cleavage
C3V43_RS00830	COG1595	DNA-templated transcription, initiation
C3V43_RS00845	COG3956	TIGRFAM MazG family protein
C3V43_RS00855	COG0525	valine-tRNA ligase activity
C3V43_RS00870	COG0653	protein targeting
C3V43_RS00900	COG4771	TonB-dependent receptor
C3V43_RS00940	COG1253	flavin adenine dinucleotide binding
C3V43_RS00945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3V43_RS00950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3V43_RS00960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C3V43_RS01005	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C3V43_RS01010	COG3437	response regulator, receiver
C3V43_RS01015	COG2205	protein histidine kinase activity
C3V43_RS01015	COG0745	RESPONSE REGULATOR receiver
C3V43_RS01015	COG3292	Two component regulator propeller
C3V43_RS01050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3V43_RS01090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3V43_RS01105	COG2217	Heavy metal translocating P-type atpase
C3V43_RS01165	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C3V43_RS01210	COG1554	hydrolase, family 65, central catalytic
C3V43_RS01230	COG1629	transport
C3V43_RS01230	COG4206	TonB-dependent receptor
C3V43_RS01235	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C3V43_RS01255	COG0534	Mate efflux family protein
C3V43_RS01285	COG0346	lactoylglutathione lyase activity
C3V43_RS01295	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C3V43_RS01300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3V43_RS01310	COG3385	transposase activity
C3V43_RS01335	COG1918	ferrous iron import across plasma membrane
C3V43_RS01335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C3V43_RS01345	COG0254	rRNA binding
C3V43_RS01350	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C3V43_RS01360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3V43_RS01365	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3V43_RS01370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C3V43_RS01375	COG1082	Xylose isomerase domain protein TIM barrel
C3V43_RS01380	COG0295	cytidine deaminase activity
C3V43_RS01385	COG3951	Flagellar rod assembly protein muramidase FlgJ
C3V43_RS01385	COG1705	Flagellar rod assembly protein muramidase FlgJ
C3V43_RS01390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3V43_RS01395	COG1136	(ABC) transporter
C3V43_RS01395	COG0577	efflux transmembrane transporter activity
C3V43_RS01405	COG1136	(ABC) transporter
C3V43_RS01410	COG1136	(ABC) transporter
C3V43_RS01410	COG0577	efflux transmembrane transporter activity
C3V43_RS01430	COG0784	Response regulator, receiver
C3V43_RS01430	COG5002	protein histidine kinase activity
C3V43_RS01440	COG0436	Aminotransferase
C3V43_RS01445	COG4591	ABC-type transport system involved in lipoprotein release permease component
C3V43_RS01450	COG1215	transferase activity, transferring glycosyl groups
C3V43_RS01455	COG0191	fructose-bisphosphate aldolase activity
C3V43_RS01460	COG0366	Alpha amylase catalytic
C3V43_RS01470	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C3V43_RS01475	COG0511	ligase activity, forming carbon-carbon bonds
C3V43_RS01485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3V43_RS01500	COG2204	response regulator
C3V43_RS01505	COG4191	Histidine kinase
C3V43_RS01510	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C3V43_RS01525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3V43_RS01550	COG0484	heat shock protein binding
C3V43_RS01555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3V43_RS01560	COG0488	(ABC) transporter
C3V43_RS01575	COG2183	response to ionizing radiation
C3V43_RS01580	COG0366	Alpha amylase catalytic
C3V43_RS01590	COG0778	Nitroreductase
C3V43_RS01605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C3V43_RS01610	COG0424	maF-like protein
C3V43_RS01625	COG0126	phosphoglycerate kinase activity
C3V43_RS01640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3V43_RS01660	COG1373	ATPase (AAA superfamily
C3V43_RS01670	COG3328	transposase activity
C3V43_RS01715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3V43_RS01720	COG1523	belongs to the glycosyl hydrolase 13 family
C3V43_RS01725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3V43_RS01735	COG0671	phosphoesterase, PA-phosphatase related
C3V43_RS01755	COG0745	RESPONSE REGULATOR receiver
C3V43_RS01765	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3V43_RS01780	COG3142	Participates in the control of copper homeostasis
C3V43_RS01785	COG1418	mRNA catabolic process
C3V43_RS01820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C3V43_RS01825	COG2832	Protein of unknown function (DUF454)
C3V43_RS01830	COG0351	phosphomethylpyrimidine kinase
C3V43_RS01840	COG0247	lactate metabolic process
C3V43_RS01845	COG1139	Iron-sulfur cluster binding protein
C3V43_RS01915	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C3V43_RS01920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3V43_RS01920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3V43_RS01940	COG0564	pseudouridine synthase activity
C3V43_RS01960	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C3V43_RS01975	COG1482	cell wall glycoprotein biosynthetic process
C3V43_RS01985	COG1215	transferase activity, transferring glycosyl groups
C3V43_RS01995	COG1805	sodium ion transport
C3V43_RS02000	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C3V43_RS02010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C3V43_RS02020	COG1979	alcohol dehydrogenase
C3V43_RS02025	COG0513	Belongs to the DEAD box helicase family
C3V43_RS02030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C3V43_RS02035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3V43_RS02050	COG1739	Uncharacterized protein family UPF0029
C3V43_RS02075	COG0513	Belongs to the DEAD box helicase family
C3V43_RS02105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3V43_RS02110	COG0242	peptide deformylase activity
C3V43_RS02120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3V43_RS02125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3V43_RS02130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3V43_RS02135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3V43_RS02145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C3V43_RS02155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3V43_RS02165	COG4771	TonB-dependent receptor
C3V43_RS02175	COG1530	ribonuclease E activity
C3V43_RS02180	COG0776	regulation of translation
C3V43_RS02185	COG1194	a g-specific adenine glycosylase
C3V43_RS02190	COG0629	single-stranded DNA binding
C3V43_RS02205	COG3033	Beta-eliminating lyase
C3V43_RS02225	COG1629	transport
C3V43_RS02225	COG4206	TonB-dependent receptor
C3V43_RS02235	COG1629	transport
C3V43_RS02235	COG4206	TonB-dependent receptor
C3V43_RS02250	COG0488	(ABC) transporter
C3V43_RS02275	COG1862	Preprotein translocase
C3V43_RS02280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3V43_RS02290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3V43_RS02300	COG0193	aminoacyl-tRNA hydrolase activity
C3V43_RS02305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C3V43_RS02310	COG0673	inositol 2-dehydrogenase activity
C3V43_RS02315	COG1760	l-serine dehydratase
C3V43_RS02320	COG1193	negative regulation of DNA recombination
C3V43_RS02340	COG4771	TonB-dependent receptor
C3V43_RS02360	COG1472	Belongs to the glycosyl hydrolase 3 family
C3V43_RS02365	COG0148	phosphopyruvate hydratase activity
C3V43_RS02370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3V43_RS02380	COG1074	ATP-dependent DNA helicase activity
C3V43_RS02390	COG0352	thiamine-phosphate diphosphorylase activity
C3V43_RS02450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3V43_RS02455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3V43_RS02465	COG0037	tRNA processing
C3V43_RS02475	COG2226	methyltransferase
C3V43_RS02490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3V43_RS02490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3V43_RS02535	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C3V43_RS02565	COG0058	SHG alpha-glucan phosphorylase activity
C3V43_RS02575	COG0716	FMN binding
C3V43_RS02585	COG1328	CTP reductase activity
C3V43_RS02590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3V43_RS02595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3V43_RS02600	COG0228	four-way junction DNA binding
C3V43_RS02605	COG2721	sulfolactate sulfo-lyase activity
C3V43_RS02610	COG1609	Transcriptional regulator
C3V43_RS02635	COG2244	polysaccharide biosynthetic process
C3V43_RS02640	COG0438	transferase activity, transferring glycosyl groups
C3V43_RS02645	COG1216	Glycosyl transferase, family 2
C3V43_RS02740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3V43_RS02745	COG0745	RESPONSE REGULATOR receiver
C3V43_RS02760	COG0159	tryptophan synthase activity
C3V43_RS02765	COG0135	phosphoribosylanthranilate isomerase activity
C3V43_RS02770	COG0134	indole-3-glycerol-phosphate synthase activity
C3V43_RS02775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3V43_RS02780	COG0512	Glutamine amidotransferase of anthranilate synthase
C3V43_RS02780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3V43_RS02785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3V43_RS02790	COG0133	tryptophan synthase activity
C3V43_RS02805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3V43_RS02810	COG0505	Belongs to the CarA family
C3V43_RS02815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C3V43_RS02830	COG4948	Mandelate Racemase Muconate Lactonizing
C3V43_RS02835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C3V43_RS02840	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C3V43_RS02845	COG1169	isochorismate synthase
C3V43_RS02855	COG0318	PFAM AMP-dependent synthetase and ligase
C3V43_RS02860	COG3263	regulation of cellular component size
C3V43_RS02865	COG3852	Histidine kinase
C3V43_RS02890	COG3385	transposase activity
C3V43_RS02895	COG0779	Required for maturation of 30S ribosomal subunits
C3V43_RS02900	COG0195	Participates in both transcription termination and antitermination
C3V43_RS02905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3V43_RS02915	COG0719	Fe-S assembly protein
C3V43_RS02920	COG0396	ATPase activity
C3V43_RS02925	COG0719	Fe-S assembly protein
C3V43_RS02930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3V43_RS02940	COG0738	Major facilitator superfamily
C3V43_RS02945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3V43_RS02975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3V43_RS02985	COG2205	protein histidine kinase activity
C3V43_RS03005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3V43_RS03010	COG2731	YhcH YjgK YiaL family protein
C3V43_RS03040	COG0351	phosphomethylpyrimidine kinase
C3V43_RS03060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C3V43_RS03065	COG2022	thiamine diphosphate biosynthetic process
C3V43_RS03070	COG0352	thiamine-phosphate diphosphorylase activity
C3V43_RS03080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C3V43_RS03095	COG1070	Carbohydrate kinase
C3V43_RS03100	COG2115	Belongs to the xylose isomerase family
C3V43_RS03105	COG2814	Major facilitator Superfamily
C3V43_RS03105	COG0477	Major facilitator Superfamily
C3V43_RS03110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3V43_RS03120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3V43_RS03135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3V43_RS03145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C3V43_RS03150	COG2096	Adenosyltransferase
C3V43_RS03155	COG1797	cobyrinic acid a,c-diamide synthase activity
C3V43_RS03160	COG1660	Displays ATPase and GTPase activities
C3V43_RS03165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3V43_RS03195	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
C3V43_RS03200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C3V43_RS03205	COG3547	Transposase (IS116 IS110 IS902 family)
C3V43_RS03215	COG0542	response to heat
C3V43_RS03225	COG0583	DNA-binding transcription factor activity
C3V43_RS03230	COG2855	membrane
C3V43_RS03255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C3V43_RS03270	COG0543	2 iron, 2 sulfur cluster binding
C3V43_RS03275	COG0167	dihydroorotate dehydrogenase activity
C3V43_RS03280	COG0336	Belongs to the RNA methyltransferase TrmD family
C3V43_RS03285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3V43_RS03290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3V43_RS03315	COG0542	response to heat
C3V43_RS03330	COG0823	Involved in the tonB-independent uptake of proteins
C3V43_RS03330	COG1506	peptidase
C3V43_RS03335	COG0534	Mate efflux family protein
C3V43_RS03345	COG0504	CTP synthase activity
C3V43_RS03365	COG4656	Part of a membrane complex involved in electron transport
C3V43_RS03370	COG4658	electron transport chain
C3V43_RS03375	COG4659	FMN binding
C3V43_RS03380	COG4660	Part of a membrane complex involved in electron transport
C3V43_RS03385	COG4657	Part of a membrane complex involved in electron transport
C3V43_RS03390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3V43_RS03410	COG3385	transposase activity
C3V43_RS03415	COG3292	Two component regulator propeller
C3V43_RS03415	COG2205	protein histidine kinase activity
C3V43_RS03415	COG0745	RESPONSE REGULATOR receiver
C3V43_RS03440	COG3279	Response regulator of the LytR AlgR family
C3V43_RS03455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C3V43_RS03465	COG1904	glucuronate isomerase
C3V43_RS03470	COG1609	Transcriptional regulator
C3V43_RS03475	COG0246	Mannitol dehydrogenase
C3V43_RS03525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3V43_RS03535	COG4864	UPF0365 protein
C3V43_RS03550	COG0037	tRNA processing
C3V43_RS03560	COG1477	protein flavinylation
C3V43_RS03565	COG1971	Probably functions as a manganese efflux pump
C3V43_RS03580	COG0463	Glycosyl transferase, family 2
C3V43_RS03605	COG0156	8-amino-7-oxononanoate synthase activity
C3V43_RS03615	COG1597	lipid kinase activity
C3V43_RS03620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3V43_RS03630	COG2957	Belongs to the agmatine deiminase family
C3V43_RS03640	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C3V43_RS03645	COG0390	transport system, permease component
C3V43_RS03650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3V43_RS03660	COG0406	alpha-ribazole phosphatase activity
C3V43_RS03670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C3V43_RS03710	COG1678	Uncharacterized ACR, COG1678
C3V43_RS03725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3V43_RS03740	COG3385	transposase activity
C3V43_RS03770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3V43_RS03775	COG0646	methionine synthase
C3V43_RS03775	COG1410	methionine synthase
C3V43_RS03780	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C3V43_RS03785	COG0572	uridine kinase
C3V43_RS03795	COG4232	protein-disulfide reductase activity
C3V43_RS03810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3V43_RS03810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3V43_RS03815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3V43_RS03820	COG0357	Ribosomal RNA small subunit methyltransferase G
C3V43_RS03845	COG4771	TonB-dependent receptor
C3V43_RS03850	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C3V43_RS03855	COG0321	lipoyl(octanoyl) transferase activity
C3V43_RS03865	COG0556	nucleotide-excision repair
C3V43_RS03875	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C3V43_RS03905	COG3942	CHAP domain
C3V43_RS03905	COG1388	LysM domain
C3V43_RS03910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3V43_RS03915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3V43_RS03935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3V43_RS03945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3V43_RS03980	COG3250	beta-galactosidase activity
C3V43_RS04000	COG3059	membrane
C3V43_RS04010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V43_RS04015	COG1120	ATPase activity
C3V43_RS04065	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C3V43_RS04160	COG4771	TonB-dependent receptor
C3V43_RS04170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C3V43_RS04180	COG1492	cobalamin metabolic process
C3V43_RS04185	COG0442	prolyl-tRNA aminoacylation
C3V43_RS04195	COG0343	queuine tRNA-ribosyltransferase activity
C3V43_RS04200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3V43_RS04205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C3V43_RS04220	COG1136	(ABC) transporter
C3V43_RS04220	COG0577	efflux transmembrane transporter activity
C3V43_RS04230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3V43_RS04235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3V43_RS04245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C3V43_RS04250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3V43_RS04265	COG1484	DNA-dependent DNA replication
C3V43_RS04295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3V43_RS04300	COG0356	it plays a direct role in the translocation of protons across the membrane
C3V43_RS04305	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3V43_RS04310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3V43_RS04315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3V43_RS04320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3V43_RS04325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3V43_RS04330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3V43_RS04335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3V43_RS04335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3V43_RS04350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3V43_RS04365	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C3V43_RS04370	COG0540	Belongs to the ATCase OTCase family
C3V43_RS04375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C3V43_RS04380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C3V43_RS04385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C3V43_RS04400	COG0513	Belongs to the DEAD box helicase family
C3V43_RS04405	COG0560	Phosphoserine phosphatase
C3V43_RS04405	COG3830	Belongs to the UPF0237 family
C3V43_RS04455	COG2304	oxidoreductase activity
C3V43_RS04470	COG0714	Associated with various cellular activities
C3V43_RS04475	COG0776	regulation of translation
C3V43_RS04485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3V43_RS04490	COG0552	protein localization to endoplasmic reticulum
C3V43_RS04500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3V43_RS04505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3V43_RS04510	COG1058	Belongs to the CinA family
C3V43_RS04510	COG1546	Belongs to the CinA family
C3V43_RS04515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3V43_RS04525	COG0305	Participates in initiation and elongation during chromosome replication
C3V43_RS04530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3V43_RS04535	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C3V43_RS04545	COG1484	DNA-dependent DNA replication
C3V43_RS04570	COG1132	(ABC) transporter
C3V43_RS04575	COG1132	(ABC) transporter
C3V43_RS04625	COG1484	DNA-dependent DNA replication
C3V43_RS04635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3V43_RS04635	COG0574	Belongs to the PEP-utilizing enzyme family
C3V43_RS04645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3V43_RS04650	COG0564	pseudouridine synthase activity
C3V43_RS04665	COG0024	Methionine aminopeptidase
C3V43_RS04675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C3V43_RS04680	COG0481	GTPase activity
C3V43_RS04695	COG0708	Exodeoxyribonuclease III
C3V43_RS04700	COG1914	H( )-stimulated, divalent metal cation uptake system
C3V43_RS04710	COG0217	transcriptional regulatory protein
C3V43_RS04715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V43_RS04715	COG0072	phenylalanine-tRNA ligase activity
C3V43_RS04725	COG0842	Transport permease protein
C3V43_RS04730	COG1131	(ABC) transporter
C3V43_RS04745	COG1917	Cupin 2, conserved barrel domain protein
C3V43_RS04745	COG2207	Transcriptional regulator
C3V43_RS04750	COG2197	response regulator
C3V43_RS04755	COG0482	sulfurtransferase activity
C3V43_RS04780	COG3507	Belongs to the glycosyl hydrolase 43 family
C3V43_RS04790	COG3507	Belongs to the glycosyl hydrolase 43 family
C3V43_RS04795	COG0745	RESPONSE REGULATOR receiver
C3V43_RS04795	COG3292	Two component regulator propeller
C3V43_RS04795	COG2205	protein histidine kinase activity
C3V43_RS04805	COG4771	TonB-dependent receptor
C3V43_RS04810	COG0702	epimerase
C3V43_RS04815	COG1629	transport
C3V43_RS04820	COG0702	epimerase
C3V43_RS04825	COG3507	Belongs to the glycosyl hydrolase 43 family
C3V43_RS04840	COG2816	NAD+ diphosphatase activity
C3V43_RS04850	COG2160	L-arabinose isomerase activity
C3V43_RS04865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C3V43_RS04870	COG0698	ribose 5-phosphate isomerase
C3V43_RS04910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C3V43_RS04910	COG0457	Tetratricopeptide repeat
C3V43_RS04945	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C3V43_RS04950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3V43_RS04950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3V43_RS04970	COG1773	rubredoxin
C3V43_RS04970	COG1592	Rubrerythrin
C3V43_RS04975	COG1595	DNA-templated transcription, initiation
C3V43_RS05010	COG2264	protein methyltransferase activity
C3V43_RS05015	COG3757	hydrolase, family 25
C3V43_RS05035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3V43_RS05040	COG2373	Large extracellular alpha-helical protein
C3V43_RS05045	COG4953	penicillin-binding protein 1C
C3V43_RS05050	COG0363	glucosamine-6-phosphate deaminase activity
C3V43_RS05065	COG1032	radical SAM domain protein
C3V43_RS05080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C3V43_RS05085	COG0463	Glycosyl transferase, family 2
C3V43_RS05090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3V43_RS05095	COG0646	methionine synthase
C3V43_RS05095	COG1410	methionine synthase
C3V43_RS05110	COG1408	metallophosphoesterase
C3V43_RS05130	COG0641	radical SAM
C3V43_RS05135	COG3591	Belongs to the peptidase S1B family
C3V43_RS05140	COG3591	Belongs to the peptidase S1B family
C3V43_RS05155	COG0131	Imidazoleglycerol-phosphate dehydratase
C3V43_RS05160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3V43_RS05165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3V43_RS05170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3V43_RS05175	COG5434	Belongs to the glycosyl hydrolase 28 family
C3V43_RS05195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3V43_RS05200	COG0793	Belongs to the peptidase S41A family
C3V43_RS05205	COG2131	deaminase
C3V43_RS05215	COG0339	signal peptide processing
C3V43_RS05225	COG1970	mechanosensitive ion channel activity
C3V43_RS05230	COG0519	Catalyzes the synthesis of GMP from XMP
C3V43_RS05230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3V43_RS05255	COG0438	transferase activity, transferring glycosyl groups
C3V43_RS05270	COG0297	glycogen (starch) synthase activity
C3V43_RS05275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3V43_RS05280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C3V43_RS05285	COG0543	2 iron, 2 sulfur cluster binding
C3V43_RS05295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3V43_RS05300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3V43_RS05305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3V43_RS05315	COG0546	phosphoglycolate phosphatase activity
C3V43_RS05320	COG3547	Transposase (IS116 IS110 IS902 family)
C3V43_RS05335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C3V43_RS05350	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C3V43_RS05355	COG3537	Alpha-1,2-mannosidase
C3V43_RS05415	COG0612	Peptidase, M16
C3V43_RS05420	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C3V43_RS05430	COG1597	lipid kinase activity
C3V43_RS05435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3V43_RS05450	COG3385	transposase activity
C3V43_RS05455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3V43_RS05465	COG2873	o-acetylhomoserine
C3V43_RS05480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3V43_RS05500	COG0523	cobalamin synthesis protein
C3V43_RS05505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C3V43_RS05510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3V43_RS05515	COG0194	GDP metabolic process
C3V43_RS05525	COG1214	PFAM Peptidase M22, glycoprotease
C3V43_RS05535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3V43_RS05540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3V43_RS05550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3V43_RS05555	COG0750	zinc metalloprotease
C3V43_RS05600	COG0673	inositol 2-dehydrogenase activity
C3V43_RS05605	COG0632	four-way junction helicase activity
C3V43_RS05610	COG0006	proline dipeptidase activity
C3V43_RS05615	COG0702	epimerase
C3V43_RS05620	COG1629	transport
C3V43_RS05630	COG4771	TonB-dependent receptor
C3V43_RS05640	COG2233	PERMEase
C3V43_RS05650	COG1575	Belongs to the MenA family. Type 1 subfamily
C3V43_RS05660	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C3V43_RS05670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3V43_RS05675	COG0617	tRNA 3'-terminal CCA addition
C3V43_RS05685	COG2204	response regulator
C3V43_RS05690	COG0488	(ABC) transporter
C3V43_RS05730	COG4771	TonB-dependent receptor
C3V43_RS05745	COG1595	DNA-templated transcription, initiation
C3V43_RS05760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C3V43_RS05770	COG1522	sequence-specific DNA binding
C3V43_RS05800	COG0811	peptide transport
C3V43_RS05810	COG0084	hydrolase, TatD family'
C3V43_RS05830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3V43_RS05835	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3V43_RS05840	COG0205	6-phosphofructokinase activity
C3V43_RS05845	COG0372	Belongs to the citrate synthase family
C3V43_RS05860	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C3V43_RS05865	COG0569	domain protein
C3V43_RS05865	COG2985	domain, Protein
C3V43_RS05870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3V43_RS05875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3V43_RS05875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3V43_RS05900	COG3681	Belongs to the UPF0597 family
C3V43_RS05905	COG1047	Peptidyl-prolyl cis-trans
C3V43_RS05910	COG0129	dihydroxy-acid dehydratase activity
C3V43_RS05930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3V43_RS05935	COG1940	carbohydrate kinase activity
C3V43_RS05940	COG0577	efflux transmembrane transporter activity
C3V43_RS05940	COG1136	(ABC) transporter
C3V43_RS05945	COG0577	efflux transmembrane transporter activity
C3V43_RS05945	COG1136	(ABC) transporter
C3V43_RS05950	COG0577	efflux transmembrane transporter activity
C3V43_RS05950	COG1136	(ABC) transporter
C3V43_RS05965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3V43_RS05970	COG2996	Protein conserved in bacteria
C3V43_RS06000	COG1506	peptidase
C3V43_RS06000	COG4946	Tricorn protease homolog
C3V43_RS06000	COG0823	Involved in the tonB-independent uptake of proteins
C3V43_RS06025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3V43_RS06030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3V43_RS06040	COG0009	L-threonylcarbamoyladenylate synthase
C3V43_RS06050	COG1609	Transcriptional regulator
C3V43_RS06050	COG2207	Transcriptional regulator
C3V43_RS06055	COG5183	chlorophyll binding
C3V43_RS06055	COG2133	pyrroloquinoline quinone binding
C3V43_RS06070	COG1785	Belongs to the alkaline phosphatase family
C3V43_RS06080	COG3537	Alpha-1,2-mannosidase
C3V43_RS06090	COG1629	transport
C3V43_RS06090	COG4206	TonB-dependent receptor
C3V43_RS06100	COG0823	Involved in the tonB-independent uptake of proteins
C3V43_RS06105	COG3022	response to hydroperoxide
C3V43_RS06110	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C3V43_RS06110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C3V43_RS06115	COG0514	ATP-dependent DNA helicase (RecQ)
C3V43_RS06135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C3V43_RS06145	COG0358	DNA primase activity
C3V43_RS06150	COG0302	gtp cyclohydrolase
C3V43_RS06160	COG0149	triose-phosphate isomerase activity
C3V43_RS06175	COG0739	heme binding
C3V43_RS06185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3V43_RS06190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3V43_RS06205	COG0848	biopolymer transport protein
C3V43_RS06210	COG0811	peptide transport
C3V43_RS06215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C3V43_RS06220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3V43_RS06225	COG0039	L-malate dehydrogenase activity
C3V43_RS06230	COG0203	ribosomal protein L17
C3V43_RS06235	COG0202	RNA polymerase activity
C3V43_RS06240	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3V43_RS06245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3V43_RS06250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3V43_RS06255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3V43_RS06260	COG3547	Transposase (IS116 IS110 IS902 family)
C3V43_RS06265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3V43_RS06280	COG0200	Binds to the 23S rRNA
C3V43_RS06285	COG1841	ribosomal large subunit assembly
C3V43_RS06290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3V43_RS06295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3V43_RS06300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3V43_RS06305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3V43_RS06310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3V43_RS06315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3V43_RS06320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3V43_RS06325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3V43_RS06330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3V43_RS06335	COG0255	Belongs to the universal ribosomal protein uL29 family
C3V43_RS06340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3V43_RS06345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3V43_RS06350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3V43_RS06355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3V43_RS06360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3V43_RS06365	COG0089	rRNA binding
C3V43_RS06370	COG0088	Forms part of the polypeptide exit tunnel
C3V43_RS06375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3V43_RS06380	COG0051	transcription antitermination factor activity, RNA binding
C3V43_RS06385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3V43_RS06390	COG0049	tRNA binding
C3V43_RS06395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3V43_RS06405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3V43_RS06410	COG0085	RNA polymerase activity
C3V43_RS06415	COG0222	ribosome binding
C3V43_RS06420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3V43_RS06425	COG0081	regulation of translation
C3V43_RS06430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3V43_RS06475	COG4974	Belongs to the 'phage' integrase family
C3V43_RS06480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C3V43_RS06485	COG0006	proline dipeptidase activity
C3V43_RS06490	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C3V43_RS06500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3V43_RS06505	COG1480	7TM receptor with intracellular HD hydrolase
C3V43_RS06515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3V43_RS06520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3V43_RS06545	COG0514	ATP-dependent DNA helicase (RecQ)
C3V43_RS06555	COG2096	Adenosyltransferase
C3V43_RS06570	COG3547	Transposase (IS116 IS110 IS902 family)
C3V43_RS06605	COG0363	glucosamine-6-phosphate deaminase activity
C3V43_RS06615	COG1242	4 iron, 4 sulfur cluster binding
C3V43_RS06650	COG1506	peptidase
C3V43_RS06650	COG0823	Involved in the tonB-independent uptake of proteins
C3V43_RS06655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3V43_RS06665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3V43_RS06670	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C3V43_RS06690	COG0546	phosphoglycolate phosphatase activity
C3V43_RS06700	COG4771	TonB-dependent receptor
C3V43_RS06715	COG1629	transport
C3V43_RS06715	COG4206	TonB-dependent receptor
C3V43_RS06725	COG3119	arylsulfatase activity
C3V43_RS06730	COG1629	transport
C3V43_RS06730	COG4206	TonB-dependent receptor
C3V43_RS06735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3V43_RS06765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C3V43_RS06770	COG2211	Major facilitator Superfamily
C3V43_RS06790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3V43_RS06800	COG0471	metal ion transport
C3V43_RS06800	COG0490	domain, Protein
C3V43_RS06835	COG0066	3-isopropylmalate dehydratase activity
C3V43_RS06840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3V43_RS06845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3V43_RS06900	COG1472	Belongs to the glycosyl hydrolase 3 family
C3V43_RS06915	COG4206	TonB-dependent receptor
C3V43_RS06915	COG1629	transport
C3V43_RS06930	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C3V43_RS06930	COG5297	Belongs to the glycosyl hydrolase family 6
C3V43_RS06935	COG1696	Membrane protein involved in D-alanine export
C3V43_RS06960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3V43_RS06970	COG1309	transcriptional regulator
C3V43_RS06975	COG2986	histidine ammonia-lyase
C3V43_RS06985	COG1228	amidohydrolase
C3V43_RS06995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C3V43_RS07010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3V43_RS07020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3V43_RS07025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C3V43_RS07030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3V43_RS07040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C3V43_RS07045	COG2333	competence protein COMEC
C3V43_RS07045	COG0658	competence protein
C3V43_RS07050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3V43_RS07075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3V43_RS07105	COG0688	phosphatidylethanolamine metabolic process
C3V43_RS07110	COG1183	phosphatidylcholine synthase activity
C3V43_RS07145	COG0590	tRNA wobble adenosine to inosine editing
C3V43_RS07165	COG0792	nuclease activity
C3V43_RS07185	COG0534	Mate efflux family protein
C3V43_RS07190	COG1132	(ABC) transporter
C3V43_RS07205	COG2217	Heavy metal translocating P-type atpase
C3V43_RS07230	COG0528	UMP kinase activity
C3V43_RS07235	COG0233	cytoplasmic translational termination
C3V43_RS07240	COG1162	GTPase activity
C3V43_RS07250	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C3V43_RS07250	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C3V43_RS07260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3V43_RS07280	COG0702	epimerase
C3V43_RS07285	COG1629	transport
C3V43_RS07290	COG4974	Belongs to the 'phage' integrase family
C3V43_RS07295	COG1629	transport
C3V43_RS07295	COG4206	TonB-dependent receptor
C3V43_RS07315	COG2003	Belongs to the UPF0758 family
C3V43_RS07320	COG0463	Glycosyl transferase, family 2
C3V43_RS07320	COG1216	Glycosyl transferase, family 2
C3V43_RS07325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3V43_RS07330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3V43_RS07345	COG0165	Argininosuccinate lyase
C3V43_RS07355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3V43_RS07360	COG2137	regulation of response to DNA damage stimulus
C3V43_RS07365	COG2890	protein-(glutamine-N5) methyltransferase activity
C3V43_RS07370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3V43_RS07370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3V43_RS07405	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C3V43_RS07425	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C3V43_RS07430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3V43_RS07435	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
C3V43_RS07440	COG0460	homoserine dehydrogenase
C3V43_RS07440	COG0527	aspartate kinase activity
C3V43_RS07450	COG0252	asparaginase activity
C3V43_RS07470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C3V43_RS07485	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C3V43_RS07535	COG4771	TonB-dependent receptor
C3V43_RS07545	COG0826	peptidase U32
C3V43_RS07560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C3V43_RS07565	COG0470	DNA polymerase III
C3V43_RS07570	COG1774	PSP1 C-terminal conserved region
C3V43_RS07585	COG0772	Belongs to the SEDS family
C3V43_RS07610	COG0138	bifunctional purine biosynthesis protein purh
C3V43_RS07620	COG3590	peptidase
C3V43_RS07625	COG0488	(ABC) transporter
C3V43_RS07635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3V43_RS07650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C3V43_RS07665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3V43_RS07680	COG1131	(ABC) transporter
C3V43_RS07715	COG0564	pseudouridine synthase activity
C3V43_RS07720	COG0823	Involved in the tonB-independent uptake of proteins
C3V43_RS07720	COG1506	peptidase
C3V43_RS07805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3V43_RS07810	COG0612	Peptidase, M16
C3V43_RS07815	COG0534	Mate efflux family protein
C3V43_RS07820	COG0784	Response regulator, receiver
C3V43_RS07820	COG2205	protein histidine kinase activity
C3V43_RS07845	COG4206	TonB-dependent receptor
C3V43_RS07845	COG1629	transport
C3V43_RS07855	COG1595	DNA-templated transcription, initiation
C3V43_RS07885	COG4206	TonB-dependent receptor
C3V43_RS07885	COG1629	transport
C3V43_RS07890	COG0702	epimerase
C3V43_RS07895	COG3119	arylsulfatase activity
C3V43_RS07910	COG0137	argininosuccinate synthase activity
C3V43_RS07915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3V43_RS07920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3V43_RS07935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3V43_RS07940	COG5002	protein histidine kinase activity
C3V43_RS07940	COG2205	protein histidine kinase activity
C3V43_RS07940	COG0784	Response regulator, receiver
C3V43_RS07945	COG1396	sequence-specific DNA binding
C3V43_RS07945	COG1917	Cupin 2, conserved barrel domain protein
C3V43_RS07950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3V43_RS07965	COG0564	pseudouridine synthase activity
C3V43_RS07995	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3V43_RS08000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3V43_RS08010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3V43_RS08025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3V43_RS08030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3V43_RS08080	COG2271	Major facilitator Superfamily
C3V43_RS08090	COG0702	epimerase
C3V43_RS08095	COG1629	transport
C3V43_RS08110	COG3385	transposase activity
C3V43_RS08120	COG0006	proline dipeptidase activity
C3V43_RS08145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C3V43_RS08150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3V43_RS08155	COG0793	Belongs to the peptidase S41A family
C3V43_RS08160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3V43_RS08190	COG2176	DNA-directed DNA polymerase activity
C3V43_RS08195	COG2816	NAD+ diphosphatase activity
C3V43_RS08215	COG0018	arginyl-trna synthetase
C3V43_RS08235	COG0708	Exodeoxyribonuclease III
C3V43_RS08240	COG0339	signal peptide processing
C3V43_RS08245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3V43_RS08255	COG4771	TonB-dependent receptor
C3V43_RS08265	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C3V43_RS08270	COG1028	Short-chain dehydrogenase reductase Sdr
C3V43_RS08320	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C3V43_RS08325	COG3250	beta-galactosidase activity
C3V43_RS08355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V43_RS08355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3V43_RS08370	COG1442	glycosyl transferase family 8
C3V43_RS08380	COG0438	transferase activity, transferring glycosyl groups
C3V43_RS08390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C3V43_RS08405	COG0545	Peptidyl-prolyl cis-trans isomerase
C3V43_RS08410	COG0545	Peptidyl-prolyl cis-trans isomerase
C3V43_RS08415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3V43_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
C3V43_RS08440	COG5002	protein histidine kinase activity
C3V43_RS08445	COG3385	transposase activity
C3V43_RS08460	COG2910	NAD(P)H-binding
C3V43_RS08465	COG1733	regulation of RNA biosynthetic process
C3V43_RS08480	COG2274	protein secretion by the type I secretion system
C3V43_RS08510	COG1215	transferase activity, transferring glycosyl groups
C3V43_RS08525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3V43_RS08530	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C3V43_RS08535	COG0612	Peptidase, M16
C3V43_RS08540	COG0681	Belongs to the peptidase S26 family
C3V43_RS08550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3V43_RS08565	COG2255	four-way junction helicase activity
C3V43_RS08580	COG3591	Belongs to the peptidase S1B family
C3V43_RS08605	COG3634	alkyl hydroperoxide reductase activity
C3V43_RS08620	COG0783	Belongs to the Dps family
C3V43_RS08625	COG5492	domain, Protein
C3V43_RS08630	COG0513	Belongs to the DEAD box helicase family
C3V43_RS08655	COG0557	exoribonuclease II activity
C3V43_RS08685	COG0674	pyruvate-flavodoxin oxidoreductase activity
C3V43_RS08685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C3V43_RS08690	COG1013	pyruvate-flavodoxin oxidoreductase activity
C3V43_RS08695	COG1012	belongs to the aldehyde dehydrogenase family
C3V43_RS08700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3V43_RS08710	COG0427	acetyl-CoA hydrolase
C3V43_RS08715	COG3250	beta-galactosidase activity
C3V43_RS08720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C3V43_RS08740	COG4206	TonB-dependent receptor
C3V43_RS08740	COG1629	transport
C3V43_RS08750	COG2252	PERMEase
C3V43_RS08765	COG0659	secondary active sulfate transmembrane transporter activity
C3V43_RS08770	COG1592	Rubrerythrin
C3V43_RS08775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C3V43_RS08780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3V43_RS08790	COG0826	peptidase U32
C3V43_RS08800	COG0758	DNA mediated transformation
C3V43_RS08805	COG0584	glycerophosphoryl diester phosphodiesterase
C3V43_RS08810	COG0671	phosphoesterase, PA-phosphatase related
C3V43_RS08815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3V43_RS08820	COG1053	succinate dehydrogenase
C3V43_RS08835	COG0671	phosphoesterase, PA-phosphatase related
C3V43_RS08840	COG3409	Peptidoglycan-binding domain 1 protein
C3V43_RS08840	COG0793	Belongs to the peptidase S41A family
C3V43_RS08845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3V43_RS08905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3V43_RS08920	COG3292	Two component regulator propeller
C3V43_RS08920	COG2205	protein histidine kinase activity
C3V43_RS08920	COG0745	RESPONSE REGULATOR receiver
C3V43_RS08930	COG2211	Major facilitator Superfamily
C3V43_RS08940	COG3661	Belongs to the glycosyl hydrolase 67 family
C3V43_RS08950	COG4771	TonB-dependent receptor
C3V43_RS08970	COG3507	Belongs to the glycosyl hydrolase 43 family
C3V43_RS08975	COG2382	esterase
C3V43_RS08985	COG1472	Belongs to the glycosyl hydrolase 3 family
C3V43_RS09015	COG0702	epimerase
C3V43_RS09020	COG1629	transport
C3V43_RS09020	COG4206	TonB-dependent receptor
C3V43_RS09025	COG0561	phosphatase activity
C3V43_RS09030	COG4771	TonB-dependent receptor
C3V43_RS09035	COG3507	Belongs to the glycosyl hydrolase 43 family
C3V43_RS09050	COG5434	Belongs to the glycosyl hydrolase 28 family
C3V43_RS09070	COG1629	transport
C3V43_RS09070	COG4206	TonB-dependent receptor
C3V43_RS09100	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C3V43_RS09105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3V43_RS09110	COG1755	Isoprenylcysteine carboxyl methyltransferase
C3V43_RS09120	COG1476	TRANSCRIPTIONal
C3V43_RS09140	COG2177	Part of the ABC transporter FtsEX involved in
C3V43_RS09150	COG1968	undecaprenyl-diphosphatase activity
C3V43_RS09155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3V43_RS09160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3V43_RS09165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C3V43_RS09225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3V43_RS09285	COG1045	serine acetyltransferase
C3V43_RS09290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C3V43_RS09290	COG0116	Belongs to the methyltransferase superfamily
C3V43_RS09300	COG1506	peptidase
C3V43_RS09300	COG0823	Involved in the tonB-independent uptake of proteins
C3V43_RS09305	COG0151	Belongs to the GarS family
C3V43_RS09320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3V43_RS09320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C3V43_RS09330	COG1121	(ABC) transporter
C3V43_RS09335	COG0606	chelatase, subunit chli
C3V43_RS09355	COG4974	Belongs to the 'phage' integrase family
C3V43_RS09360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3V43_RS09375	COG4591	ABC-type transport system involved in lipoprotein release permease component
C3V43_RS09380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3V43_RS09390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C3V43_RS09395	COG1854	S-ribosylhomocysteine lyase activity
C3V43_RS09410	COG0318	PFAM AMP-dependent synthetase and ligase
C3V43_RS09420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3V43_RS09425	COG1217	gtp-binding protein TYPA
C3V43_RS09430	COG1611	Belongs to the LOG family
C3V43_RS09445	COG0594	ribonuclease P activity
C3V43_RS09450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3V43_RS09460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3V43_RS09505	COG1522	sequence-specific DNA binding
C3V43_RS09510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3V43_RS09510	COG0731	radical SAM domain protein
C3V43_RS09525	COG0784	Response regulator, receiver
C3V43_RS09525	COG2205	protein histidine kinase activity
C3V43_RS09530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3V43_RS09535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3V43_RS09540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C3V43_RS09545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3V43_RS09555	COG0495	leucyl-tRNA aminoacylation
C3V43_RS09560	COG0697	spore germination
C3V43_RS09570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C3V43_RS09570	COG2755	lipolytic protein G-D-S-L family
C3V43_RS09590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3V43_RS09600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3V43_RS09605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3V43_RS09620	COG0012	GTP binding
C3V43_RS09630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3V43_RS09630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3V43_RS09635	COG0142	geranyltranstransferase activity
C3V43_RS09645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C3V43_RS09650	COG1694	Mazg nucleotide pyrophosphohydrolase
C3V43_RS09655	COG1490	D-aminoacyl-tRNA deacylase activity
C3V43_RS09660	COG0322	excinuclease ABC activity
C3V43_RS09665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3V43_RS09685	COG3291	Pkd domain containing protein
C3V43_RS09715	COG3292	Two component regulator propeller
C3V43_RS09715	COG2205	protein histidine kinase activity
C3V43_RS09715	COG0745	RESPONSE REGULATOR receiver
C3V43_RS09720	COG1629	transport
C3V43_RS09720	COG4206	TonB-dependent receptor
C3V43_RS09740	COG3507	Belongs to the glycosyl hydrolase 43 family
C3V43_RS09760	COG1629	transport
C3V43_RS09775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3V43_RS09780	COG2715	membrane protein required for spore maturation
C3V43_RS09785	COG2234	aminopeptidase activity
C3V43_RS09800	COG4771	TonB-dependent receptor
C3V43_RS09810	COG3119	arylsulfatase activity
C3V43_RS09810	COG3408	Glycogen debranching enzyme
C3V43_RS09820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3V43_RS09825	COG0702	epimerase
C3V43_RS09830	COG4771	TonB-dependent receptor
C3V43_RS09835	COG3119	arylsulfatase activity
C3V43_RS09840	COG2205	protein histidine kinase activity
C3V43_RS09840	COG3292	Two component regulator propeller
C3V43_RS09840	COG0745	RESPONSE REGULATOR receiver
C3V43_RS09840	COG2205	protein histidine kinase activity
C3V43_RS09840	COG0745	RESPONSE REGULATOR receiver
C3V43_RS09840	COG3292	Two component regulator propeller
C3V43_RS09880	COG1629	transport
C3V43_RS09885	COG0702	epimerase
C3V43_RS09915	COG0501	Belongs to the peptidase M48B family
C3V43_RS09920	COG1704	LemA family
C3V43_RS09970	COG3023	N-Acetylmuramoyl-L-alanine amidase
C3V43_RS10000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3V43_RS10010	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C3V43_RS10015	COG3119	arylsulfatase activity
C3V43_RS10045	COG0205	6-phosphofructokinase activity
C3V43_RS10055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3V43_RS10060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3V43_RS10065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C3V43_RS10070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3V43_RS10110	COG0562	UDP-galactopyranose mutase
C3V43_RS10115	COG0438	transferase activity, transferring glycosyl groups
C3V43_RS10125	COG1368	sulfuric ester hydrolase activity
C3V43_RS10130	COG1132	(ABC) transporter
C3V43_RS10140	COG3119	arylsulfatase activity
C3V43_RS10145	COG3341	Caulimovirus viroplasmin
C3V43_RS10145	COG0328	RNA-DNA hybrid ribonuclease activity
C3V43_RS10155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3V43_RS10160	COG1166	arginine decarboxylase activity
C3V43_RS10165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3V43_RS10170	COG1595	DNA-templated transcription, initiation
C3V43_RS10200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3V43_RS10205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3V43_RS10210	COG0745	RESPONSE REGULATOR receiver
C3V43_RS10210	COG2205	protein histidine kinase activity
C3V43_RS10210	COG3292	Two component regulator propeller
C3V43_RS10220	COG4771	TonB-dependent receptor
C3V43_RS10225	COG0702	epimerase
C3V43_RS10230	COG3693	PFAM glycoside hydrolase, family 10
C3V43_RS10230	COG3507	Belongs to the glycosyl hydrolase 43 family
C3V43_RS10230	COG2382	esterase
C3V43_RS10235	COG2382	esterase
C3V43_RS10235	COG3693	PFAM glycoside hydrolase, family 10
C3V43_RS10240	COG1472	Belongs to the glycosyl hydrolase 3 family
C3V43_RS10245	COG1472	Belongs to the glycosyl hydrolase 3 family
C3V43_RS10270	COG4771	TonB-dependent receptor
C3V43_RS10280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C3V43_RS10285	COG0445	tRNA wobble uridine modification
C3V43_RS10300	COG1940	carbohydrate kinase activity
C3V43_RS10310	COG2271	Major facilitator Superfamily
C3V43_RS10315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3V43_RS10340	COG1629	transport
C3V43_RS10340	COG4206	TonB-dependent receptor
C3V43_RS10345	COG0702	epimerase
C3V43_RS10355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C3V43_RS10370	COG0393	Putative heavy-metal-binding
C3V43_RS10375	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C3V43_RS10380	COG3119	arylsulfatase activity
C3V43_RS10390	COG1629	transport
C3V43_RS10390	COG4206	TonB-dependent receptor
C3V43_RS10395	COG3250	beta-galactosidase activity
C3V43_RS10410	COG3408	Glycogen debranching enzyme
C3V43_RS10410	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C3V43_RS10415	COG3250	beta-galactosidase activity
C3V43_RS10420	COG2431	L-lysine efflux transmembrane transporter activity
C3V43_RS10430	COG0702	epimerase
C3V43_RS10435	COG1629	transport
C3V43_RS10435	COG4206	TonB-dependent receptor
C3V43_RS10450	COG0656	L-ascorbic acid biosynthetic process
C3V43_RS10480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3V43_RS10525	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C3V43_RS10540	COG0187	DNA topoisomerase II activity
C3V43_RS10545	COG0268	Binds directly to 16S ribosomal RNA
C3V43_RS10555	COG1381	Involved in DNA repair and RecF pathway recombination
C3V43_RS10570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3V43_RS10585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3V43_RS10590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3V43_RS10595	COG0772	Belongs to the SEDS family
C3V43_RS10600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3V43_RS10605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3V43_RS10610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3V43_RS10615	COG0768	penicillin binding
C3V43_RS10630	COG2001	Belongs to the MraZ family
C3V43_RS10645	COG1595	DNA-templated transcription, initiation
C3V43_RS10665	COG0756	dUTP diphosphatase activity
C3V43_RS10680	COG4942	peptidase
C3V43_RS10685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3V43_RS10695	COG1022	Amp-dependent synthetase and ligase
C3V43_RS10700	COG0612	Peptidase, M16
C3V43_RS10705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C3V43_RS10730	COG2954	triphosphatase activity
C3V43_RS10780	COG1349	DNA-binding transcription factor activity
C3V43_RS10785	COG3547	Transposase (IS116 IS110 IS902 family)
C3V43_RS10790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3V43_RS10790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3V43_RS10795	COG3959	Transketolase, thiamine diphosphate binding domain
C3V43_RS10800	COG3958	Transketolase
C3V43_RS10805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3V43_RS10820	COG4771	TonB-dependent receptor
C3V43_RS10825	COG0702	epimerase
C3V43_RS10835	COG2382	esterase
C3V43_RS10840	COG1472	Belongs to the glycosyl hydrolase 3 family
C3V43_RS10855	COG0423	glycine-tRNA ligase activity
C3V43_RS10870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C3V43_RS10885	COG0277	FAD linked oxidase domain protein
C3V43_RS10890	COG3876	Protein conserved in bacteria
C3V43_RS10910	COG1216	Glycosyl transferase, family 2
C3V43_RS10910	COG0463	Glycosyl transferase, family 2
C3V43_RS10915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3V43_RS10925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3V43_RS10930	COG3876	Protein conserved in bacteria
C3V43_RS10945	COG1629	transport
C3V43_RS10945	COG4206	TonB-dependent receptor
C3V43_RS10965	COG1151	hydroxylamine reductase activity
C3V43_RS10975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C3V43_RS10980	COG0589	response to stress
C3V43_RS10980	COG0475	glutathione-regulated potassium exporter activity
C3V43_RS10985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C3V43_RS10990	COG1136	(ABC) transporter
C3V43_RS11000	COG0733	neurotransmitter:sodium symporter activity
C3V43_RS11010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3V43_RS11025	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3V43_RS11030	COG1785	Belongs to the alkaline phosphatase family
C3V43_RS11035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3V43_RS11040	COG0280	phosphate acetyltransferase
C3V43_RS11045	COG1380	Effector of murein hydrolase LrgA
C3V43_RS11050	COG1346	cytolysis
C3V43_RS11070	COG0312	modulator of DNA gyrase
C3V43_RS11075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C3V43_RS11080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3V43_RS11140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3V43_RS11145	COG1283	sodium-dependent phosphate transmembrane transporter activity
C3V43_RS11150	COG1773	rubredoxin
C3V43_RS11155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3V43_RS11160	COG1011	Hydrolase
C3V43_RS11165	COG0196	riboflavin kinase activity
C3V43_RS11175	COG4771	TonB-dependent receptor
C3V43_RS11180	COG1266	CAAX protease self-immunity
C3V43_RS11190	COG3655	Transcriptional regulator
C3V43_RS11195	COG2166	iron-sulfur cluster assembly
C3V43_RS11210	COG0280	phosphate acetyltransferase
C3V43_RS11215	COG3426	butyrate kinase activity
C3V43_RS11225	COG1353	crispr-associated protein
C3V43_RS11235	COG1337	RAMP superfamily
C3V43_RS11290	COG2801	Transposase and inactivated derivatives
C3V43_RS11300	COG1185	polyribonucleotide nucleotidyltransferase activity
C3V43_RS11310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3V43_RS11315	COG0537	adenosine 5'-monophosphoramidase activity
C3V43_RS11370	COG3392	D12 class N6 adenine-specific DNA methyltransferase
C3V43_RS11385	COG0628	permease
C3V43_RS11400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3V43_RS11415	COG2095	MarC family integral membrane protein
C3V43_RS11455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3V43_RS11475	COG4948	Mandelate Racemase Muconate Lactonizing
C3V43_RS11490	COG3250	beta-galactosidase activity
C3V43_RS11495	COG2205	protein histidine kinase activity
C3V43_RS11495	COG0745	RESPONSE REGULATOR receiver
C3V43_RS11495	COG3292	Two component regulator propeller
C3V43_RS11500	COG4206	TonB-dependent receptor
C3V43_RS11500	COG1629	transport
C3V43_RS11505	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C3V43_RS11545	COG4206	TonB-dependent receptor
C3V43_RS11565	COG0482	sulfurtransferase activity
C3V43_RS11575	COG1570	exodeoxyribonuclease VII activity
C3V43_RS11580	COG1722	exodeoxyribonuclease VII activity
C3V43_RS11585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3V43_RS11590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3V43_RS11595	COG0489	protein tyrosine kinase activity
C3V43_RS11610	COG3118	belongs to the thioredoxin family
C3V43_RS11645	COG3292	Two component regulator propeller
C3V43_RS11645	COG2205	protein histidine kinase activity
C3V43_RS11645	COG0745	RESPONSE REGULATOR receiver
C3V43_RS11650	COG1501	Belongs to the glycosyl hydrolase 31 family
C3V43_RS11660	COG1629	transport
C3V43_RS11660	COG4206	TonB-dependent receptor
C3V43_RS11670	COG3547	Transposase (IS116 IS110 IS902 family)
C3V43_RS11705	COG0681	Belongs to the peptidase S26 family
C3V43_RS11735	COG0673	inositol 2-dehydrogenase activity
C3V43_RS11740	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3V43_RS11775	COG1119	ATPase activity
C3V43_RS11785	COG0668	transmembrane transport
C3V43_RS11790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3V43_RS11795	COG0569	domain protein
C3V43_RS11800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3V43_RS11825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3V43_RS11830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3V43_RS11835	COG0805	protein transport
C3V43_RS11850	COG1979	alcohol dehydrogenase
C3V43_RS11860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3V43_RS11870	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3V43_RS11875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C3V43_RS11875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3V43_RS11880	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3V43_RS11885	COG1078	dGTPase activity
C3V43_RS11925	COG0459	protein refolding
C3V43_RS11930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3V43_RS11935	COG0124	histidyl-tRNA synthetase
C3V43_RS11950	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3V43_RS11975	COG0514	ATP-dependent DNA helicase (RecQ)
C3V43_RS11990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3V43_RS12005	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3V43_RS12010	COG2086	electron transfer activity
C3V43_RS12025	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3V43_RS12030	COG3385	transposase activity
C3V43_RS12045	COG1621	beta-fructofuranosidase activity
C3V43_RS12050	COG1621	beta-fructofuranosidase activity
C3V43_RS12065	COG3292	Two component regulator propeller
C3V43_RS12065	COG2205	protein histidine kinase activity
C3V43_RS12065	COG0745	RESPONSE REGULATOR receiver
C3V43_RS12070	COG4771	TonB-dependent receptor
C3V43_RS12145	COG1309	transcriptional regulator
C3V43_RS12205	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C3V43_RS12210	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C3V43_RS12230	COG1373	ATPase (AAA superfamily
C3V43_RS12265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3V43_RS12275	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C3V43_RS12290	COG0148	phosphopyruvate hydratase activity
C3V43_RS12350	COG2885	chlorophyll binding
C3V43_RS12405	COG4771	TonB-dependent receptor
C3V43_RS12415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C3V43_RS12430	COG1280	lysine exporter protein (LysE YggA)
C3V43_RS12435	COG0047	phosphoribosylformylglycinamidine synthase activity
C3V43_RS12435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3V43_RS12440	COG0745	RESPONSE REGULATOR receiver
C3V43_RS12440	COG2205	protein histidine kinase activity
C3V43_RS12440	COG3292	Two component regulator propeller
C3V43_RS12455	COG1649	PFAM Uncharacterised BCR, COG1649
C3V43_RS12480	COG1966	Carbon starvation protein
C3V43_RS12485	COG1649	PFAM Uncharacterised BCR, COG1649
C3V43_RS12495	COG4974	Belongs to the 'phage' integrase family
C3V43_RS12500	COG4974	Belongs to the 'phage' integrase family
C3V43_RS12545	COG3385	transposase activity
C3V43_RS12590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3V43_RS12595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3V43_RS12595	COG0551	DNA topoisomerase type I activity
C3V43_RS12790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C3V43_RS12800	COG0788	formyltetrahydrofolate deformylase activity
C3V43_RS12810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3V43_RS12815	COG0107	imidazoleglycerol-phosphate synthase activity
C3V43_RS12820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3V43_RS12820	COG0140	phosphoribosyl-ATP diphosphatase activity
C3V43_RS12825	COG2884	Cell division ATP-binding protein ftsE
C3V43_RS12830	COG0527	aspartate kinase activity
C3V43_RS12835	COG0019	diaminopimelate decarboxylase activity
C3V43_RS12850	COG0534	Mate efflux family protein
C3V43_RS12860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3V43_RS12865	COG0156	8-amino-7-oxononanoate synthase activity
C3V43_RS12880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3V43_RS12885	COG0321	lipoyl(octanoyl) transferase activity
C3V43_RS12885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C3V43_RS12900	COG0592	DNA-directed DNA polymerase activity
C3V43_RS12915	COG0497	DNA recombination
C3V43_RS12920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3V43_RS12935	COG0285	dihydrofolate synthase activity
C3V43_RS12940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3V43_RS12955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C3V43_RS12965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C3V43_RS13005	COG0556	nucleotide-excision repair
C3V43_RS13030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3V43_RS13045	COG4974	Belongs to the 'phage' integrase family
C3V43_RS13075	COG2972	Histidine kinase
C3V43_RS13080	COG3279	Response regulator of the LytR AlgR family
C3V43_RS13140	COG0586	Pfam SNARE associated Golgi protein
C3V43_RS13150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3V43_RS13165	COG0307	riboflavin synthase, alpha
C3V43_RS13170	COG0778	Nitroreductase
C3V43_RS13175	COG1295	ribonuclease BN
C3V43_RS13190	COG4948	Mandelate Racemase Muconate Lactonizing
C3V43_RS13200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3V43_RS13205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3V43_RS13230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C3V43_RS13245	COG1595	DNA-templated transcription, initiation
C3V43_RS13270	COG0686	Belongs to the AlaDH PNT family
C3V43_RS13275	COG0739	heme binding
C3V43_RS13285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3V43_RS13300	COG3119	arylsulfatase activity
C3V43_RS13305	COG0318	PFAM AMP-dependent synthetase and ligase
C3V43_RS13310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3V43_RS13315	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C3V43_RS13360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3V43_RS13365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C3V43_RS13370	COG0363	glucosamine-6-phosphate deaminase activity
C3V43_RS13375	COG3279	Response regulator of the LytR AlgR family
C3V43_RS13385	COG1136	(ABC) transporter
C3V43_RS13385	COG0577	efflux transmembrane transporter activity
C3V43_RS13390	COG1136	(ABC) transporter
C3V43_RS13395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3V43_RS13420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3V43_RS13430	COG4221	oxidoreductase activity
C3V43_RS13445	COG0488	(ABC) transporter
C3V43_RS13450	COG4206	TonB-dependent receptor
C3V43_RS13450	COG1629	transport
C3V43_RS13460	COG1864	DNA RNA non-specific endonuclease
C3V43_RS13460	COG3591	Belongs to the peptidase S1B family
C3V43_RS13470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3V43_RS13475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3V43_RS13495	COG0612	Peptidase, M16
C3V43_RS13535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C3V43_RS13545	COG1086	Polysaccharide biosynthesis protein
C3V43_RS13550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3V43_RS13555	COG1083	cytidylyl-transferase
C3V43_RS13575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3V43_RS13580	COG1028	Short-chain dehydrogenase reductase Sdr
C3V43_RS13585	COG2089	acid synthase
C3V43_RS13590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3V43_RS13600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3V43_RS13605	COG3959	Transketolase, thiamine diphosphate binding domain
C3V43_RS13610	COG3958	Transketolase
C3V43_RS13655	COG0110	maltose O-acetyltransferase activity
C3V43_RS13660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3V43_RS13705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3V43_RS13715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3V43_RS13720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3V43_RS13735	COG0443	Heat shock 70 kDa protein
C3V43_RS13755	COG3385	transposase activity
C3V43_RS13810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3V43_RS13830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3V43_RS13840	COG1956	GAF domain-containing protein
C3V43_RS13850	COG0101	tRNA pseudouridine synthase activity
C3V43_RS13860	COG2205	protein histidine kinase activity
C3V43_RS13860	COG0745	RESPONSE REGULATOR receiver
C3V43_RS13860	COG3292	Two component regulator propeller
C3V43_RS13865	COG3250	beta-galactosidase activity
C3V43_RS13870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C3V43_RS13890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C3V43_RS13890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3V43_RS13940	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C3V43_RS13945	COG0563	adenylate kinase activity
C3V43_RS13950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3V43_RS13955	COG1496	oxidoreductase activity
C3V43_RS13970	COG1702	phosphate starvation-inducible protein PhoH
C3V43_RS13975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3V43_RS13980	COG2226	methyltransferase
C3V43_RS13985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3V43_RS14000	COG1704	LemA family
C3V43_RS14010	COG1733	regulation of RNA biosynthetic process
C3V43_RS14015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3V43_RS14025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3V43_RS14030	COG0284	orotidine-5'-phosphate decarboxylase activity
C3V43_RS14035	COG3385	transposase activity
C3V43_RS14050	COG0582	viral genome integration into host DNA
C3V43_RS14055	COG4974	Belongs to the 'phage' integrase family
C3V43_RS14170	COG3385	transposase activity
C3V43_RS14175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C3V43_RS14180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C3V43_RS14185	COG1663	tetraacyldisaccharide 4'-kinase activity
C3V43_RS14190	COG0616	signal peptide processing
C3V43_RS14235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3V43_RS14240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3V43_RS14245	COG1160	GTP binding
C3V43_RS14250	COG1127	ABC transporter
C3V43_RS14255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3V43_RS14275	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3V43_RS14280	COG0740	serine-type endopeptidase activity
C3V43_RS14285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3V43_RS14290	COG0514	ATP-dependent DNA helicase (RecQ)
C3V43_RS14295	COG0517	IMP dehydrogenase activity
C3V43_RS14295	COG0516	GMP reductase activity
C3V43_RS14300	COG0110	maltose O-acetyltransferase activity
C3V43_RS14320	COG1187	pseudouridine synthase activity
C3V43_RS14325	COG0017	Asparaginyl-tRNA synthetase
C3V43_RS14335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3V43_RS14340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3V43_RS14345	COG0052	Belongs to the universal ribosomal protein uS2 family
C3V43_RS14350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3V43_RS14365	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C3V43_RS14370	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3V43_RS14375	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3V43_RS14395	COG1051	belongs to the nudix hydrolase family
C3V43_RS14420	COG0463	Glycosyl transferase, family 2
C3V43_RS14440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3V43_RS14445	COG2502	aspartate--ammonia ligase
C3V43_RS14455	COG0335	large ribosomal subunit rRNA binding
C3V43_RS14460	COG0737	Belongs to the 5'-nucleotidase family
C3V43_RS14465	COG0737	Belongs to the 5'-nucleotidase family
C3V43_RS14470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C3V43_RS14475	COG1472	Belongs to the glycosyl hydrolase 3 family
C3V43_RS14515	COG3459	Glycosyltransferase 36 associated
C3V43_RS14520	COG3250	beta-galactosidase activity
C3V43_RS14525	COG2207	Transcriptional regulator
C3V43_RS14525	COG1917	Cupin 2, conserved barrel domain protein
C3V43_RS14530	COG3458	cephalosporin-C deacetylase activity
C3V43_RS14545	COG1629	transport
C3V43_RS14545	COG4206	TonB-dependent receptor
C3V43_RS14580	COG4124	Belongs to the glycosyl hydrolase 26 family
C3V43_RS14585	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C3V43_RS14590	COG2211	Major facilitator Superfamily
C3V43_RS14595	COG2942	2-epimerase
C3V43_RS14600	COG4206	TonB-dependent receptor
C3V43_RS14600	COG1629	transport
C3V43_RS14605	COG0702	epimerase
C3V43_RS14615	COG0745	RESPONSE REGULATOR receiver
C3V43_RS14615	COG2205	protein histidine kinase activity
C3V43_RS14615	COG3292	Two component regulator propeller
C3V43_RS14635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3V43_RS14640	COG0436	Aminotransferase
C3V43_RS14650	COG2205	protein histidine kinase activity
C3V43_RS14650	COG2202	Pas domain