locus-tag	class	description
K8P02_RS00025	COG4771	TonB-dependent receptor
K8P02_RS00030	COG4974	Belongs to the 'phage' integrase family
K8P02_RS00035	COG1629	transport
K8P02_RS00035	COG4206	TonB-dependent receptor
K8P02_RS00055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K8P02_RS00065	COG2205	protein histidine kinase activity
K8P02_RS00065	COG0745	RESPONSE REGULATOR receiver
K8P02_RS00065	COG3292	Two component regulator propeller
K8P02_RS00065	COG2205	protein histidine kinase activity
K8P02_RS00065	COG0745	RESPONSE REGULATOR receiver
K8P02_RS00065	COG3292	Two component regulator propeller
K8P02_RS00080	COG1629	transport
K8P02_RS00095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K8P02_RS00095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K8P02_RS00120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8P02_RS00125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8P02_RS00130	COG1162	GTPase activity
K8P02_RS00135	COG0233	cytoplasmic translational termination
K8P02_RS00140	COG0528	UMP kinase activity
K8P02_RS00145	COG5433	transposase activity
K8P02_RS00155	COG0534	Mate efflux family protein
K8P02_RS00175	COG0792	nuclease activity
K8P02_RS00195	COG1183	phosphatidylcholine synthase activity
K8P02_RS00200	COG0688	phosphatidylethanolamine metabolic process
K8P02_RS00245	COG0714	Associated with various cellular activities
K8P02_RS00265	COG0802	atpase or kinase
K8P02_RS00270	COG0745	RESPONSE REGULATOR receiver
K8P02_RS00280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K8P02_RS00290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K8P02_RS00300	COG4771	TonB-dependent receptor
K8P02_RS00325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K8P02_RS00340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8P02_RS00345	COG0742	ribosomal rna small subunit methyltransferase
K8P02_RS00390	COG1629	transport
K8P02_RS00390	COG4206	TonB-dependent receptor
K8P02_RS00395	COG3537	Alpha-1,2-mannosidase
K8P02_RS00415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K8P02_RS00420	COG0739	heme binding
K8P02_RS00430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K8P02_RS00435	COG1388	LysM domain
K8P02_RS00435	COG3942	CHAP domain
K8P02_RS00445	COG1475	DNA binding
K8P02_RS00450	COG1192	Involved in chromosome partitioning
K8P02_RS00455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K8P02_RS00460	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8P02_RS00475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K8P02_RS00490	COG4974	Belongs to the 'phage' integrase family
K8P02_RS00535	COG3023	N-Acetylmuramoyl-L-alanine amidase
K8P02_RS00560	COG1196	nuclear chromosome segregation
K8P02_RS00565	COG2239	Acts as a magnesium transporter
K8P02_RS00570	COG2194	sulfuric ester hydrolase activity
K8P02_RS00575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K8P02_RS00585	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8P02_RS00605	COG3279	Response regulator of the LytR AlgR family
K8P02_RS00610	COG3275	phosphorelay sensor kinase activity
K8P02_RS00710	COG0668	transmembrane transport
K8P02_RS00715	COG0662	Cupin 2, conserved barrel domain protein
K8P02_RS00715	COG2207	Transcriptional regulator
K8P02_RS00720	COG0667	Aldo Keto reductase
K8P02_RS00725	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K8P02_RS00730	COG2211	Major facilitator Superfamily
K8P02_RS00735	COG2942	2-epimerase
K8P02_RS00760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8P02_RS00765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K8P02_RS00770	COG0713	ATP synthesis coupled electron transport
K8P02_RS00775	COG0839	Belongs to the complex I subunit 6 family
K8P02_RS00785	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K8P02_RS00790	COG0649	NAD binding
K8P02_RS00790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8P02_RS00800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8P02_RS00805	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8P02_RS00815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8P02_RS00820	COG0569	domain protein
K8P02_RS00830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K8P02_RS00845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K8P02_RS00850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K8P02_RS00855	COG0805	protein transport
K8P02_RS00865	COG1917	Cupin 2, conserved barrel domain protein
K8P02_RS00865	COG4977	sequence-specific DNA binding
K8P02_RS00875	COG2271	Major facilitator Superfamily
K8P02_RS00880	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS00890	COG1917	Cupin 2, conserved barrel domain protein
K8P02_RS00895	COG2755	lipolytic protein G-D-S-L family
K8P02_RS00905	COG3292	Two component regulator propeller
K8P02_RS00905	COG0745	RESPONSE REGULATOR receiver
K8P02_RS00905	COG2205	protein histidine kinase activity
K8P02_RS00930	COG0326	Molecular chaperone. Has ATPase activity
K8P02_RS00945	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS00955	COG0702	epimerase
K8P02_RS00960	COG4771	TonB-dependent receptor
K8P02_RS00965	COG3458	cephalosporin-C deacetylase activity
K8P02_RS00970	COG0657	acetylesterase activity
K8P02_RS00970	COG2755	lipolytic protein G-D-S-L family
K8P02_RS00975	COG0546	phosphoglycolate phosphatase activity
K8P02_RS01000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K8P02_RS01020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K8P02_RS01030	COG5433	transposase activity
K8P02_RS01040	COG3279	Response regulator of the LytR AlgR family
K8P02_RS01045	COG1242	4 iron, 4 sulfur cluster binding
K8P02_RS01055	COG0363	glucosamine-6-phosphate deaminase activity
K8P02_RS01060	COG0009	L-threonylcarbamoyladenylate synthase
K8P02_RS01070	COG4585	Histidine kinase
K8P02_RS01075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K8P02_RS01085	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8P02_RS01090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K8P02_RS01090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8P02_RS01095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8P02_RS01100	COG1078	dGTPase activity
K8P02_RS01105	COG0284	orotidine-5'-phosphate decarboxylase activity
K8P02_RS01110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K8P02_RS01115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K8P02_RS01120	COG1704	LemA family
K8P02_RS01135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K8P02_RS01140	COG2226	methyltransferase
K8P02_RS01145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K8P02_RS01150	COG1702	phosphate starvation-inducible protein PhoH
K8P02_RS01160	COG2268	Band 7 protein
K8P02_RS01215	COG2205	protein histidine kinase activity
K8P02_RS01215	COG0745	RESPONSE REGULATOR receiver
K8P02_RS01215	COG3292	Two component regulator propeller
K8P02_RS01220	COG0101	tRNA pseudouridine synthase activity
K8P02_RS01240	COG3250	beta-galactosidase activity
K8P02_RS01290	COG2885	chlorophyll binding
K8P02_RS01305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K8P02_RS01345	COG3681	Belongs to the UPF0597 family
K8P02_RS01355	COG0129	dihydroxy-acid dehydratase activity
K8P02_RS01360	COG0028	Belongs to the TPP enzyme family
K8P02_RS01375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K8P02_RS01380	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K8P02_RS01390	COG0538	isocitrate dehydrogenase activity
K8P02_RS01395	COG0372	Belongs to the citrate synthase family
K8P02_RS01400	COG0205	6-phosphofructokinase activity
K8P02_RS01405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K8P02_RS01410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K8P02_RS01435	COG0084	hydrolase, TatD family'
K8P02_RS01445	COG0811	peptide transport
K8P02_RS01475	COG1522	sequence-specific DNA binding
K8P02_RS01485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K8P02_RS01500	COG1595	DNA-templated transcription, initiation
K8P02_RS01545	COG0488	(ABC) transporter
K8P02_RS01550	COG2204	response regulator
K8P02_RS01560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K8P02_RS01565	COG0793	Belongs to the peptidase S41A family
K8P02_RS01570	COG2131	deaminase
K8P02_RS01580	COG0339	signal peptide processing
K8P02_RS01590	COG1970	mechanosensitive ion channel activity
K8P02_RS01595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K8P02_RS01595	COG0519	Catalyzes the synthesis of GMP from XMP
K8P02_RS01620	COG3537	Alpha-1,2-mannosidase
K8P02_RS01630	COG4771	TonB-dependent receptor
K8P02_RS01635	COG0561	phosphatase activity
K8P02_RS01645	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS01660	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS01670	COG2755	lipolytic protein G-D-S-L family
K8P02_RS01685	COG2205	protein histidine kinase activity
K8P02_RS01685	COG3292	Two component regulator propeller
K8P02_RS01685	COG0745	RESPONSE REGULATOR receiver
K8P02_RS01715	COG0297	glycogen (starch) synthase activity
K8P02_RS01720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K8P02_RS01725	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K8P02_RS01730	COG0543	2 iron, 2 sulfur cluster binding
K8P02_RS01735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K8P02_RS01740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K8P02_RS01745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K8P02_RS01750	COG0546	phosphoglycolate phosphatase activity
K8P02_RS01760	COG0791	NLP P60 protein
K8P02_RS01775	COG0612	Peptidase, M16
K8P02_RS01780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K8P02_RS01785	COG1597	lipid kinase activity
K8P02_RS01790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K8P02_RS01805	COG3448	diguanylate cyclase activity
K8P02_RS01805	COG4175	Glycine betaine
K8P02_RS01815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K8P02_RS01825	COG2211	Major facilitator Superfamily
K8P02_RS01855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K8P02_RS01870	COG1674	ftsk spoiiie
K8P02_RS01880	COG0492	ferredoxin-NADP+ reductase activity
K8P02_RS01885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS01920	COG4206	TonB-dependent receptor
K8P02_RS01920	COG1629	transport
K8P02_RS01935	COG4733	cellulase activity
K8P02_RS01935	COG5297	Belongs to the glycosyl hydrolase family 6
K8P02_RS01945	COG0539	negative regulation of cytoplasmic translation
K8P02_RS01950	COG1234	tRNA 3'-trailer cleavage
K8P02_RS01960	COG2989	Protein conserved in bacteria
K8P02_RS01965	COG1595	DNA-templated transcription, initiation
K8P02_RS01980	COG3956	TIGRFAM MazG family protein
K8P02_RS01990	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
K8P02_RS02005	COG0525	valine-tRNA ligase activity
K8P02_RS02010	COG5002	protein histidine kinase activity
K8P02_RS02010	COG0784	Response regulator, receiver
K8P02_RS02010	COG2205	protein histidine kinase activity
K8P02_RS02030	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
K8P02_RS02075	COG1086	Polysaccharide biosynthesis protein
K8P02_RS02090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K8P02_RS02095	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K8P02_RS02170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8P02_RS02180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K8P02_RS02195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K8P02_RS02215	COG1253	flavin adenine dinucleotide binding
K8P02_RS02220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8P02_RS02225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K8P02_RS02235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K8P02_RS02280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K8P02_RS02280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K8P02_RS02290	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K8P02_RS02295	COG0563	adenylate kinase activity
K8P02_RS02305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K8P02_RS02310	COG1496	oxidoreductase activity
K8P02_RS02325	COG2706	6-phosphogluconolactonase activity
K8P02_RS02330	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS02345	COG1629	transport
K8P02_RS02345	COG4206	TonB-dependent receptor
K8P02_RS02360	COG0366	Alpha amylase catalytic
K8P02_RS02370	COG1082	Xylose isomerase domain protein TIM barrel
K8P02_RS02380	COG0516	GMP reductase activity
K8P02_RS02380	COG0517	IMP dehydrogenase activity
K8P02_RS02405	COG1162	GTPase activity
K8P02_RS02435	COG3142	Participates in the control of copper homeostasis
K8P02_RS02440	COG1418	mRNA catabolic process
K8P02_RS02490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K8P02_RS02495	COG2832	Protein of unknown function (DUF454)
K8P02_RS02500	COG0720	synthase
K8P02_RS02510	COG0247	lactate metabolic process
K8P02_RS02515	COG1139	Iron-sulfur cluster binding protein
K8P02_RS02525	COG0351	phosphomethylpyrimidine kinase
K8P02_RS02530	COG2304	oxidoreductase activity
K8P02_RS02535	COG1629	transport
K8P02_RS02545	COG4948	Mandelate Racemase Muconate Lactonizing
K8P02_RS02560	COG4206	TonB-dependent receptor
K8P02_RS02560	COG1629	transport
K8P02_RS02580	COG1393	Belongs to the ArsC family
K8P02_RS02590	COG4771	TonB-dependent receptor
K8P02_RS02630	COG0728	peptidoglycan biosynthetic process
K8P02_RS02645	COG0463	Glycosyl transferase, family 2
K8P02_RS02660	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS02665	COG0367	asparagine synthase
K8P02_RS02670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8P02_RS02675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K8P02_RS02680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8P02_RS02685	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS02700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K8P02_RS02710	COG1509	lysine 2,3-aminomutase activity
K8P02_RS02720	COG1115	amino acid carrier protein
K8P02_RS02735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K8P02_RS02735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K8P02_RS02755	COG1285	pathogenesis
K8P02_RS02770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8P02_RS02775	COG0741	lytic transglycosylase activity
K8P02_RS02775	COG1388	LysM domain
K8P02_RS02785	COG1090	epimerase
K8P02_RS02815	COG0545	Peptidyl-prolyl cis-trans isomerase
K8P02_RS02835	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K8P02_RS02840	COG0456	acetyltransferase
K8P02_RS02855	COG1401	restriction endodeoxyribonuclease activity
K8P02_RS02880	COG0564	pseudouridine synthase activity
K8P02_RS02900	COG2837	iron assimilation
K8P02_RS02915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8P02_RS02920	COG1063	alcohol dehydrogenase
K8P02_RS02945	COG3550	peptidyl-serine autophosphorylation
K8P02_RS02975	COG0556	nucleotide-excision repair
K8P02_RS03060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K8P02_RS03080	COG0813	purine-nucleoside phosphorylase activity
K8P02_RS03085	COG4864	UPF0365 protein
K8P02_RS03100	COG0037	tRNA processing
K8P02_RS03110	COG1477	protein flavinylation
K8P02_RS03115	COG1971	Probably functions as a manganese efflux pump
K8P02_RS03130	COG0463	Glycosyl transferase, family 2
K8P02_RS03150	COG4771	TonB-dependent receptor
K8P02_RS03155	COG0702	epimerase
K8P02_RS03175	COG0148	phosphopyruvate hydratase activity
K8P02_RS03180	COG5433	transposase activity
K8P02_RS03190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K8P02_RS03200	COG1082	Xylose isomerase domain protein TIM barrel
K8P02_RS03205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K8P02_RS03210	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8P02_RS03215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K8P02_RS03220	COG4651	solute:proton antiporter activity
K8P02_RS03220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K8P02_RS03230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K8P02_RS03235	COG0193	aminoacyl-tRNA hydrolase activity
K8P02_RS03240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K8P02_RS03250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8P02_RS03255	COG1862	Preprotein translocase
K8P02_RS03265	COG0237	dephospho-CoA kinase activity
K8P02_RS03285	COG0542	response to heat
K8P02_RS03295	COG0583	DNA-binding transcription factor activity
K8P02_RS03335	COG3345	alpha-galactosidase
K8P02_RS03350	COG1629	transport
K8P02_RS03350	COG4206	TonB-dependent receptor
K8P02_RS03360	COG4771	TonB-dependent receptor
K8P02_RS03375	COG3940	Belongs to the glycosyl hydrolase 43 family
K8P02_RS03385	COG2855	membrane
K8P02_RS03395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K8P02_RS03415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8P02_RS03425	COG0443	Heat shock 70 kDa protein
K8P02_RS03445	COG0514	ATP-dependent DNA helicase (RecQ)
K8P02_RS03480	COG0667	Aldo Keto reductase
K8P02_RS03495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K8P02_RS03510	COG1940	carbohydrate kinase activity
K8P02_RS03520	COG3119	arylsulfatase activity
K8P02_RS03530	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS03535	COG0702	epimerase
K8P02_RS03540	COG4771	TonB-dependent receptor
K8P02_RS03550	COG0745	RESPONSE REGULATOR receiver
K8P02_RS03550	COG2205	protein histidine kinase activity
K8P02_RS03550	COG3292	Two component regulator propeller
K8P02_RS03555	COG0702	epimerase
K8P02_RS03560	COG1629	transport
K8P02_RS03560	COG4206	TonB-dependent receptor
K8P02_RS03565	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K8P02_RS03570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8P02_RS03595	COG3119	arylsulfatase activity
K8P02_RS03615	COG1760	l-serine dehydratase
K8P02_RS03620	COG0598	Magnesium transport protein CorA
K8P02_RS03625	COG1193	negative regulation of DNA recombination
K8P02_RS03680	COG4804	nuclease activity
K8P02_RS03690	COG0798	PFAM Bile acid sodium symporter
K8P02_RS03695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K8P02_RS03730	COG0745	RESPONSE REGULATOR receiver
K8P02_RS03730	COG3292	Two component regulator propeller
K8P02_RS03730	COG2205	protein histidine kinase activity
K8P02_RS03730	COG0745	RESPONSE REGULATOR receiver
K8P02_RS03730	COG2205	protein histidine kinase activity
K8P02_RS03730	COG3292	Two component regulator propeller
K8P02_RS03745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS03765	COG3189	MarR family transcriptional regulator
K8P02_RS03770	COG3537	Alpha-1,2-mannosidase
K8P02_RS03775	COG0561	phosphatase activity
K8P02_RS03780	COG1169	isochorismate synthase
K8P02_RS03785	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K8P02_RS03790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K8P02_RS03795	COG4948	Mandelate Racemase Muconate Lactonizing
K8P02_RS03815	COG1629	transport
K8P02_RS03815	COG4206	TonB-dependent receptor
K8P02_RS03835	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS03840	COG3250	beta-galactosidase activity
K8P02_RS03850	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K8P02_RS03855	COG3537	Alpha-1,2-mannosidase
K8P02_RS03860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS03865	COG0783	Belongs to the Dps family
K8P02_RS03890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K8P02_RS03900	COG1882	Formate acetyltransferase
K8P02_RS03915	COG3292	Two component regulator propeller
K8P02_RS03915	COG0745	RESPONSE REGULATOR receiver
K8P02_RS03915	COG2205	protein histidine kinase activity
K8P02_RS03930	COG4771	TonB-dependent receptor
K8P02_RS03935	COG0702	epimerase
K8P02_RS03985	COG3119	arylsulfatase activity
K8P02_RS04005	COG2205	protein histidine kinase activity
K8P02_RS04010	COG0745	RESPONSE REGULATOR receiver
K8P02_RS04020	COG1253	flavin adenine dinucleotide binding
K8P02_RS04025	COG0501	Belongs to the peptidase M48B family
K8P02_RS04055	COG0482	sulfurtransferase activity
K8P02_RS04060	COG2197	response regulator
K8P02_RS04090	COG2814	Major facilitator Superfamily
K8P02_RS04095	COG4953	penicillin-binding protein 1C
K8P02_RS04100	COG2373	Large extracellular alpha-helical protein
K8P02_RS04160	COG3385	transposase activity
K8P02_RS04180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K8P02_RS04185	COG1410	methionine synthase
K8P02_RS04185	COG0646	methionine synthase
K8P02_RS04190	COG0778	Nitroreductase
K8P02_RS04220	COG0572	uridine kinase
K8P02_RS04230	COG4232	protein-disulfide reductase activity
K8P02_RS04235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8P02_RS04245	COG4206	TonB-dependent receptor
K8P02_RS04245	COG1629	transport
K8P02_RS04265	COG4948	Mandelate Racemase Muconate Lactonizing
K8P02_RS04275	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS04285	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS04315	COG2755	lipolytic protein G-D-S-L family
K8P02_RS04315	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K8P02_RS04320	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS04330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8P02_RS04340	COG1404	Belongs to the peptidase S8 family
K8P02_RS04360	COG4771	TonB-dependent receptor
K8P02_RS04395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K8P02_RS04400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K8P02_RS04405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K8P02_RS04410	COG0131	Imidazoleglycerol-phosphate dehydratase
K8P02_RS04415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K8P02_RS04415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K8P02_RS04425	COG1773	rubredoxin
K8P02_RS04425	COG1592	Rubrerythrin
K8P02_RS04460	COG3591	Belongs to the peptidase S1B family
K8P02_RS04465	COG3591	Belongs to the peptidase S1B family
K8P02_RS04470	COG0641	radical SAM
K8P02_RS04510	COG5002	protein histidine kinase activity
K8P02_RS04515	COG2205	protein histidine kinase activity
K8P02_RS04520	COG0420	3'-5' exonuclease activity
K8P02_RS04530	COG1408	metallophosphoesterase
K8P02_RS04545	COG1410	methionine synthase
K8P02_RS04545	COG0646	methionine synthase
K8P02_RS04550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K8P02_RS04555	COG0463	Glycosyl transferase, family 2
K8P02_RS04560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K8P02_RS04565	COG1032	radical SAM domain protein
K8P02_RS04600	COG2365	Tyrosine phosphatase family
K8P02_RS04605	COG0363	glucosamine-6-phosphate deaminase activity
K8P02_RS04625	COG1752	Esterase of the alpha-beta hydrolase superfamily
K8P02_RS04660	COG2264	protein methyltransferase activity
K8P02_RS04680	COG0590	tRNA wobble adenosine to inosine editing
K8P02_RS04695	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8P02_RS04700	COG0022	dehydrogenase e1 component
K8P02_RS04725	COG1595	DNA-templated transcription, initiation
K8P02_RS04735	COG0673	inositol 2-dehydrogenase activity
K8P02_RS04740	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K8P02_RS04780	COG0698	ribose 5-phosphate isomerase
K8P02_RS04785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K8P02_RS04790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K8P02_RS04805	COG1482	cell wall glycoprotein biosynthetic process
K8P02_RS04825	COG0513	Belongs to the DEAD box helicase family
K8P02_RS04830	COG4221	oxidoreductase activity
K8P02_RS04845	COG1218	3'(2'),5'-bisphosphate nucleotidase
K8P02_RS04850	COG0471	metal ion transport
K8P02_RS04850	COG3273	potassium ion transport
K8P02_RS04855	COG0529	Catalyzes the synthesis of activated sulfate
K8P02_RS04860	COG0175	sulfate reduction
K8P02_RS04865	COG2895	sulfate adenylyltransferase (ATP) activity
K8P02_RS04910	COG4974	Belongs to the 'phage' integrase family
K8P02_RS05130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8P02_RS05130	COG2205	protein histidine kinase activity
K8P02_RS05130	COG2198	Histidine kinase
K8P02_RS05130	COG0784	Response regulator, receiver
K8P02_RS05150	COG0551	DNA topoisomerase type I activity
K8P02_RS05150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K8P02_RS05185	COG4974	Belongs to the 'phage' integrase family
K8P02_RS05190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K8P02_RS05195	COG0242	peptide deformylase activity
K8P02_RS05205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K8P02_RS05210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K8P02_RS05215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K8P02_RS05220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K8P02_RS05230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K8P02_RS05235	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K8P02_RS05250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K8P02_RS05285	COG1940	carbohydrate kinase activity
K8P02_RS05290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K8P02_RS05300	COG2271	Major facilitator Superfamily
K8P02_RS05310	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS05320	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
K8P02_RS05330	COG0657	acetylesterase activity
K8P02_RS05330	COG2755	lipolytic protein G-D-S-L family
K8P02_RS05335	COG1629	transport
K8P02_RS05335	COG4206	TonB-dependent receptor
K8P02_RS05340	COG0702	epimerase
K8P02_RS05370	COG0484	heat shock protein binding
K8P02_RS05375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K8P02_RS05380	COG0488	(ABC) transporter
K8P02_RS05405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8P02_RS05410	COG0745	RESPONSE REGULATOR receiver
K8P02_RS05410	COG2205	protein histidine kinase activity
K8P02_RS05410	COG3292	Two component regulator propeller
K8P02_RS05420	COG0252	asparaginase activity
K8P02_RS05425	COG0159	tryptophan synthase activity
K8P02_RS05430	COG0135	phosphoribosylanthranilate isomerase activity
K8P02_RS05435	COG0134	indole-3-glycerol-phosphate synthase activity
K8P02_RS05440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K8P02_RS05450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K8P02_RS05455	COG0133	tryptophan synthase activity
K8P02_RS05460	COG1979	alcohol dehydrogenase
K8P02_RS05475	COG0004	ammonium transporteR
K8P02_RS05480	COG0347	Belongs to the P(II) protein family
K8P02_RS05495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K8P02_RS05505	COG0584	glycerophosphoryl diester phosphodiesterase
K8P02_RS05515	COG0367	asparagine synthase
K8P02_RS05525	COG0070	glutamate synthase
K8P02_RS05525	COG0069	glutamate synthase activity
K8P02_RS05525	COG0067	glutamate synthase
K8P02_RS05530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K8P02_RS05540	COG0505	Belongs to the CarA family
K8P02_RS05545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K8P02_RS05550	COG3093	addiction module antidote protein HigA
K8P02_RS05610	COG1216	Glycosyl transferase, family 2
K8P02_RS05625	COG1216	Glycosyl transferase, family 2
K8P02_RS05635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8P02_RS05650	COG1295	ribonuclease BN
K8P02_RS05665	COG4948	Mandelate Racemase Muconate Lactonizing
K8P02_RS05670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8P02_RS05675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8P02_RS05700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8P02_RS05700	COG2207	Transcriptional regulator
K8P02_RS05745	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K8P02_RS05765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K8P02_RS05775	COG0058	SHG alpha-glucan phosphorylase activity
K8P02_RS05780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8P02_RS05790	COG1176	ABC-type spermidine putrescine transport system, permease component I
K8P02_RS05795	COG1177	transmembrane transport
K8P02_RS05810	COG0724	RNA recognition motif
K8P02_RS05815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K8P02_RS05820	COG2205	protein histidine kinase activity
K8P02_RS05825	COG0745	RESPONSE REGULATOR receiver
K8P02_RS05845	COG0463	Glycosyl transferase, family 2
K8P02_RS05870	COG0228	four-way junction DNA binding
K8P02_RS05890	COG1131	(ABC) transporter
K8P02_RS05895	COG0842	Transport permease protein
K8P02_RS05900	COG0842	Transport permease protein
K8P02_RS05910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K8P02_RS05915	COG0556	nucleotide-excision repair
K8P02_RS05920	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K8P02_RS05950	COG1388	LysM domain
K8P02_RS05950	COG3942	CHAP domain
K8P02_RS05965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K8P02_RS05970	COG3104	oligopeptide transport
K8P02_RS05975	COG2909	trisaccharide binding
K8P02_RS05985	COG4206	TonB-dependent receptor
K8P02_RS05985	COG1629	transport
K8P02_RS06030	COG1695	Transcriptional regulator
K8P02_RS06060	COG0823	Involved in the tonB-independent uptake of proteins
K8P02_RS06060	COG1506	peptidase
K8P02_RS06065	COG0534	Mate efflux family protein
K8P02_RS06075	COG0504	CTP synthase activity
K8P02_RS06095	COG4656	Part of a membrane complex involved in electron transport
K8P02_RS06100	COG4658	electron transport chain
K8P02_RS06105	COG4659	FMN binding
K8P02_RS06110	COG4660	Part of a membrane complex involved in electron transport
K8P02_RS06115	COG4657	Part of a membrane complex involved in electron transport
K8P02_RS06120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K8P02_RS06125	COG2059	Chromate
K8P02_RS06130	COG2059	Chromate
K8P02_RS06135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K8P02_RS06150	COG2721	sulfolactate sulfo-lyase activity
K8P02_RS06155	COG1609	Transcriptional regulator
K8P02_RS06175	COG3610	response to peptide
K8P02_RS06195	COG2985	domain, Protein
K8P02_RS06195	COG0490	domain, Protein
K8P02_RS06215	COG4771	TonB-dependent receptor
K8P02_RS06220	COG1858	cytochrome C peroxidase
K8P02_RS06280	COG0716	FMN binding
K8P02_RS06285	COG0138	bifunctional purine biosynthesis protein purh
K8P02_RS06295	COG2197	response regulator
K8P02_RS06310	COG0305	Participates in initiation and elongation during chromosome replication
K8P02_RS06325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K8P02_RS06345	COG4771	TonB-dependent receptor
K8P02_RS06350	COG0702	epimerase
K8P02_RS06380	COG0745	RESPONSE REGULATOR receiver
K8P02_RS06380	COG2205	protein histidine kinase activity
K8P02_RS06380	COG3292	Two component regulator propeller
K8P02_RS06385	COG0072	phenylalanine-tRNA ligase activity
K8P02_RS06385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8P02_RS06390	COG0217	transcriptional regulatory protein
K8P02_RS06415	COG0708	Exodeoxyribonuclease III
K8P02_RS06420	COG0432	Pfam Uncharacterised protein family UPF0047
K8P02_RS06440	COG0481	GTPase activity
K8P02_RS06450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K8P02_RS06460	COG0024	Methionine aminopeptidase
K8P02_RS06465	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS06485	COG0564	pseudouridine synthase activity
K8P02_RS06490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K8P02_RS06495	COG0574	Belongs to the PEP-utilizing enzyme family
K8P02_RS06495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K8P02_RS06510	COG0352	thiamine-phosphate diphosphorylase activity
K8P02_RS06515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8P02_RS06530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K8P02_RS06535	COG2022	thiamine diphosphate biosynthetic process
K8P02_RS06540	COG0352	thiamine-phosphate diphosphorylase activity
K8P02_RS06570	COG2249	NAD(P)H dehydrogenase (quinone) activity
K8P02_RS06640	COG1082	Xylose isomerase domain protein TIM barrel
K8P02_RS06660	COG2205	protein histidine kinase activity
K8P02_RS06660	COG3292	Two component regulator propeller
K8P02_RS06660	COG0745	RESPONSE REGULATOR receiver
K8P02_RS06715	COG3250	beta-galactosidase activity
K8P02_RS06740	COG0702	epimerase
K8P02_RS06745	COG4206	TonB-dependent receptor
K8P02_RS06745	COG1629	transport
K8P02_RS06770	COG2376	Dihydroxyacetone kinase
K8P02_RS06790	COG0515	serine threonine protein kinase
K8P02_RS06790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K8P02_RS06795	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K8P02_RS06800	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS06805	COG3250	beta-galactosidase activity
K8P02_RS06840	COG4974	Belongs to the 'phage' integrase family
K8P02_RS06930	COG4974	Belongs to the 'phage' integrase family
K8P02_RS06945	COG3292	Two component regulator propeller
K8P02_RS06945	COG0745	RESPONSE REGULATOR receiver
K8P02_RS06945	COG2205	protein histidine kinase activity
K8P02_RS06980	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS06990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS06995	COG4771	TonB-dependent receptor
K8P02_RS07005	COG4771	TonB-dependent receptor
K8P02_RS07010	COG0702	epimerase
K8P02_RS07025	COG4771	TonB-dependent receptor
K8P02_RS07040	COG4948	Mandelate Racemase Muconate Lactonizing
K8P02_RS07050	COG0657	acetylesterase activity
K8P02_RS07050	COG2755	lipolytic protein G-D-S-L family
K8P02_RS07060	COG3969	phosphoadenosine phosphosulfate
K8P02_RS07065	COG1475	DNA binding
K8P02_RS07080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8P02_RS07090	COG2205	protein histidine kinase activity
K8P02_RS07105	COG0300	oxidoreductase activity
K8P02_RS07170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8P02_RS07190	COG0442	prolyl-tRNA aminoacylation
K8P02_RS07195	COG0745	RESPONSE REGULATOR receiver
K8P02_RS07200	COG5002	protein histidine kinase activity
K8P02_RS07240	COG1733	regulation of RNA biosynthetic process
K8P02_RS07265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K8P02_RS07270	COG1058	Belongs to the CinA family
K8P02_RS07270	COG1546	Belongs to the CinA family
K8P02_RS07275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K8P02_RS07280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K8P02_RS07290	COG0552	protein localization to endoplasmic reticulum
K8P02_RS07295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8P02_RS07305	COG2823	Periplasmic or secreted lipoprotein
K8P02_RS07305	COG1652	LysM domain
K8P02_RS07310	COG0714	Associated with various cellular activities
K8P02_RS07325	COG2304	oxidoreductase activity
K8P02_RS07330	COG2304	oxidoreductase activity
K8P02_RS07370	COG0542	response to heat
K8P02_RS07375	COG0326	Molecular chaperone. Has ATPase activity
K8P02_RS07400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K8P02_RS07410	COG0336	Belongs to the RNA methyltransferase TrmD family
K8P02_RS07415	COG0167	dihydroorotate dehydrogenase activity
K8P02_RS07420	COG0543	2 iron, 2 sulfur cluster binding
K8P02_RS07435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K8P02_RS07455	COG1538	Outer membrane efflux protein
K8P02_RS07465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K8P02_RS07475	COG0346	lactoylglutathione lyase activity
K8P02_RS07515	COG1136	(ABC) transporter
K8P02_RS07515	COG0577	efflux transmembrane transporter activity
K8P02_RS07525	COG2957	Belongs to the agmatine deiminase family
K8P02_RS07540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K8P02_RS07545	COG1597	lipid kinase activity
K8P02_RS07550	COG0156	8-amino-7-oxononanoate synthase activity
K8P02_RS07555	COG1136	(ABC) transporter
K8P02_RS07555	COG0577	efflux transmembrane transporter activity
K8P02_RS07585	COG5000	phosphorelay sensor kinase activity
K8P02_RS07610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K8P02_RS07615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K8P02_RS07620	COG0343	queuine tRNA-ribosyltransferase activity
K8P02_RS07635	COG3830	Belongs to the UPF0237 family
K8P02_RS07635	COG0560	Phosphoserine phosphatase
K8P02_RS07640	COG0513	Belongs to the DEAD box helicase family
K8P02_RS07665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8P02_RS07670	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS07675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K8P02_RS07690	COG1696	Membrane protein involved in D-alanine export
K8P02_RS07720	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS07755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8P02_RS07760	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K8P02_RS07765	COG0657	acetylesterase activity
K8P02_RS07765	COG2755	lipolytic protein G-D-S-L family
K8P02_RS07790	COG0246	Mannitol dehydrogenase
K8P02_RS07795	COG1609	Transcriptional regulator
K8P02_RS07800	COG1904	glucuronate isomerase
K8P02_RS07825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K8P02_RS07850	COG3385	transposase activity
K8P02_RS07860	COG1690	Belongs to the RtcB family
K8P02_RS07875	COG1252	NADH dehydrogenase
K8P02_RS07910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8P02_RS07925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K8P02_RS07935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K8P02_RS07945	COG1858	cytochrome C peroxidase
K8P02_RS07950	COG0724	RNA recognition motif
K8P02_RS07955	COG0450	alkyl hydroperoxide reductase
K8P02_RS07960	COG2814	Major facilitator Superfamily
K8P02_RS07960	COG0477	Major facilitator Superfamily
K8P02_RS07965	COG2115	Belongs to the xylose isomerase family
K8P02_RS07995	COG0351	phosphomethylpyrimidine kinase
K8P02_RS08000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K8P02_RS08005	COG0724	RNA recognition motif
K8P02_RS08030	COG0671	phosphoesterase, PA-phosphatase related
K8P02_RS08070	COG2223	nitrite transmembrane transporter activity
K8P02_RS08075	COG2949	membrane
K8P02_RS08100	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K8P02_RS08105	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
K8P02_RS08120	COG0673	inositol 2-dehydrogenase activity
K8P02_RS08150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K8P02_RS08185	COG2205	protein histidine kinase activity
K8P02_RS08190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K8P02_RS08205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K8P02_RS08215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K8P02_RS08220	COG0540	Belongs to the ATCase OTCase family
K8P02_RS08225	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K8P02_RS08240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K8P02_RS08250	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K8P02_RS08265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K8P02_RS08305	COG1091	dTDP-4-dehydrorhamnose reductase activity
K8P02_RS08330	COG0464	growth
K8P02_RS08340	COG4977	sequence-specific DNA binding
K8P02_RS08360	COG1064	alcohol dehydrogenase
K8P02_RS08380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K8P02_RS08385	COG0784	Response regulator, receiver
K8P02_RS08385	COG2205	protein histidine kinase activity
K8P02_RS08385	COG2198	Histidine kinase
K8P02_RS08405	COG0667	Aldo Keto reductase
K8P02_RS08470	COG1678	Uncharacterized ACR, COG1678
K8P02_RS08480	COG1215	transferase activity, transferring glycosyl groups
K8P02_RS08490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K8P02_RS08525	COG3250	beta-galactosidase activity
K8P02_RS08540	COG0321	lipoyl(octanoyl) transferase activity
K8P02_RS08545	COG2217	Heavy metal translocating P-type atpase
K8P02_RS08575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8P02_RS08585	COG0778	Nitroreductase
K8P02_RS08605	COG1739	Uncharacterized protein family UPF0029
K8P02_RS08615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K8P02_RS08620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K8P02_RS08625	COG0513	Belongs to the DEAD box helicase family
K8P02_RS08645	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K8P02_RS08650	COG1805	sodium ion transport
K8P02_RS08655	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K8P02_RS08705	COG1216	Glycosyl transferase, family 2
K8P02_RS08710	COG2244	polysaccharide biosynthetic process
K8P02_RS08720	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS08725	COG1215	transferase activity, transferring glycosyl groups
K8P02_RS08740	COG2198	Histidine kinase
K8P02_RS08740	COG0784	Response regulator, receiver
K8P02_RS08740	COG5002	protein histidine kinase activity
K8P02_RS08760	COG0488	(ABC) transporter
K8P02_RS08805	COG0428	transporter
K8P02_RS08810	COG2226	methyltransferase
K8P02_RS08825	COG4771	TonB-dependent receptor
K8P02_RS08840	COG1132	(ABC) transporter
K8P02_RS08845	COG2375	cellular response to nickel ion
K8P02_RS08845	COG1132	(ABC) transporter
K8P02_RS09040	COG0697	spore germination
K8P02_RS09055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8P02_RS09075	COG1704	LemA family
K8P02_RS09080	COG0501	Belongs to the peptidase M48B family
K8P02_RS09085	COG0612	Peptidase, M16
K8P02_RS09115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K8P02_RS09120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K8P02_RS09150	COG1136	(ABC) transporter
K8P02_RS09160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K8P02_RS09185	COG1151	hydroxylamine reductase activity
K8P02_RS09190	COG3263	regulation of cellular component size
K8P02_RS09200	COG1022	Amp-dependent synthetase and ligase
K8P02_RS09305	COG0443	Heat shock 70 kDa protein
K8P02_RS09315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K8P02_RS09350	COG1073	alpha beta
K8P02_RS09365	COG4206	TonB-dependent receptor
K8P02_RS09365	COG1629	transport
K8P02_RS09380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K8P02_RS09395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K8P02_RS09400	COG0586	Pfam SNARE associated Golgi protein
K8P02_RS09405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K8P02_RS09410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K8P02_RS09415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K8P02_RS09420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K8P02_RS09425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K8P02_RS09430	COG0356	it plays a direct role in the translocation of protons across the membrane
K8P02_RS09445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K8P02_RS09450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K8P02_RS09460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8P02_RS09475	COG0673	inositol 2-dehydrogenase activity
K8P02_RS09505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K8P02_RS09510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K8P02_RS09525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K8P02_RS09545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K8P02_RS09550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K8P02_RS09560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K8P02_RS09570	COG0534	Mate efflux family protein
K8P02_RS09585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8P02_RS09590	COG1136	(ABC) transporter
K8P02_RS09595	COG0577	efflux transmembrane transporter activity
K8P02_RS09595	COG1136	(ABC) transporter
K8P02_RS09605	COG3279	Response regulator of the LytR AlgR family
K8P02_RS09635	COG0363	glucosamine-6-phosphate deaminase activity
K8P02_RS09640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K8P02_RS09645	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K8P02_RS09650	COG1301	dicarboxylic acid transport
K8P02_RS09660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K8P02_RS09665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8P02_RS09675	COG3119	arylsulfatase activity
K8P02_RS09685	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K8P02_RS09695	COG0534	Mate efflux family protein
K8P02_RS09735	COG0673	inositol 2-dehydrogenase activity
K8P02_RS09755	COG0702	epimerase
K8P02_RS09760	COG4771	TonB-dependent receptor
K8P02_RS09775	COG1917	Cupin 2, conserved barrel domain protein
K8P02_RS09775	COG4977	sequence-specific DNA binding
K8P02_RS09780	COG4771	TonB-dependent receptor
K8P02_RS09795	COG0737	Belongs to the 5'-nucleotidase family
K8P02_RS09805	COG2183	response to ionizing radiation
K8P02_RS09825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8P02_RS09830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8P02_RS09920	COG0358	DNA primase activity
K8P02_RS10055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8P02_RS10055	COG2198	Histidine kinase
K8P02_RS10055	COG2205	protein histidine kinase activity
K8P02_RS10055	COG0784	Response regulator, receiver
K8P02_RS10135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K8P02_RS10135	COG0551	DNA topoisomerase type I activity
K8P02_RS10170	COG4974	Belongs to the 'phage' integrase family
K8P02_RS10195	COG1442	glycosyl transferase family 8
K8P02_RS10195	COG1216	Glycosyl transferase, family 2
K8P02_RS10205	COG5039	Polysaccharide pyruvyl transferase
K8P02_RS10235	COG0778	Nitroreductase
K8P02_RS10245	COG0704	Plays a role in the regulation of phosphate uptake
K8P02_RS10250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K8P02_RS10255	COG0581	inorganic phosphate transmembrane transporter activity
K8P02_RS10260	COG0573	inorganic phosphate transmembrane transporter activity
K8P02_RS10270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K8P02_RS10290	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K8P02_RS10310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8P02_RS10360	COG0463	Glycosyl transferase, family 2
K8P02_RS10360	COG1216	Glycosyl transferase, family 2
K8P02_RS10385	COG3206	protein involved in exopolysaccharide biosynthesis
K8P02_RS10385	COG0489	protein tyrosine kinase activity
K8P02_RS10390	COG4464	protein tyrosine phosphatase activity
K8P02_RS10405	COG4948	Mandelate Racemase Muconate Lactonizing
K8P02_RS10410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K8P02_RS10435	COG0497	DNA recombination
K8P02_RS10470	COG0321	lipoyl(octanoyl) transferase activity
K8P02_RS10470	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K8P02_RS10475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K8P02_RS10485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8P02_RS10490	COG0156	8-amino-7-oxononanoate synthase activity
K8P02_RS10500	COG5002	protein histidine kinase activity
K8P02_RS10500	COG2205	protein histidine kinase activity
K8P02_RS10500	COG0784	Response regulator, receiver
K8P02_RS10515	COG0019	diaminopimelate decarboxylase activity
K8P02_RS10520	COG0527	aspartate kinase activity
K8P02_RS10525	COG2884	Cell division ATP-binding protein ftsE
K8P02_RS10530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K8P02_RS10530	COG0140	phosphoribosyl-ATP diphosphatase activity
K8P02_RS10540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K8P02_RS10545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K8P02_RS10550	COG0788	formyltetrahydrofolate deformylase activity
K8P02_RS10575	COG2818	Glycosylase
K8P02_RS10580	COG0693	protein deglycase activity
K8P02_RS10610	COG2819	hydrolase of the alpha beta superfamily
K8P02_RS10645	COG1620	l-lactate permease
K8P02_RS10665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8P02_RS10680	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS10680	COG0297	glycogen (starch) synthase activity
K8P02_RS10705	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS10710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K8P02_RS10715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8P02_RS10785	COG0702	epimerase
K8P02_RS10790	COG4771	TonB-dependent receptor
K8P02_RS10795	COG2814	Major facilitator Superfamily
K8P02_RS10815	COG2140	Oxalate decarboxylase
K8P02_RS10820	COG0662	Cupin 2, conserved barrel domain protein
K8P02_RS10820	COG2207	Transcriptional regulator
K8P02_RS10825	COG1312	Catalyzes the dehydration of D-mannonate
K8P02_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
K8P02_RS10835	COG1609	Transcriptional regulator
K8P02_RS10865	COG4771	TonB-dependent receptor
K8P02_RS10880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K8P02_RS10880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K8P02_RS10895	COG2226	methyltransferase
K8P02_RS10945	COG0577	efflux transmembrane transporter activity
K8P02_RS10945	COG1136	(ABC) transporter
K8P02_RS10950	COG1136	(ABC) transporter
K8P02_RS10950	COG0577	efflux transmembrane transporter activity
K8P02_RS10965	COG2204	response regulator
K8P02_RS10970	COG4191	Histidine kinase
K8P02_RS10975	COG0628	permease
K8P02_RS10980	COG1215	transferase activity, transferring glycosyl groups
K8P02_RS10995	COG0436	Aminotransferase
K8P02_RS11010	COG0488	(ABC) transporter
K8P02_RS11030	COG0745	RESPONSE REGULATOR receiver
K8P02_RS11045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8P02_RS11075	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS11080	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS11110	COG3594	Acyltransferase
K8P02_RS11140	COG4206	TonB-dependent receptor
K8P02_RS11155	COG3033	Beta-eliminating lyase
K8P02_RS11185	COG0629	single-stranded DNA binding
K8P02_RS11200	COG1530	ribonuclease E activity
K8P02_RS11210	COG2315	Protein conserved in bacteria
K8P02_RS11215	COG1979	alcohol dehydrogenase
K8P02_RS11240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K8P02_RS11250	COG2985	domain, Protein
K8P02_RS11265	COG2204	response regulator
K8P02_RS11275	COG0784	Response regulator, receiver
K8P02_RS11275	COG2205	protein histidine kinase activity
K8P02_RS11280	COG1136	(ABC) transporter
K8P02_RS11280	COG0577	efflux transmembrane transporter activity
K8P02_RS11285	COG0577	efflux transmembrane transporter activity
K8P02_RS11295	COG0577	efflux transmembrane transporter activity
K8P02_RS11295	COG1136	(ABC) transporter
K8P02_RS11305	COG1136	(ABC) transporter
K8P02_RS11335	COG1705	Flagellar rod assembly protein muramidase FlgJ
K8P02_RS11345	COG0662	Cupin 2, conserved barrel domain protein
K8P02_RS11345	COG2207	Transcriptional regulator
K8P02_RS11350	COG3059	membrane
K8P02_RS11355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8P02_RS11365	COG0488	(ABC) transporter
K8P02_RS11385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8P02_RS11390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K8P02_RS11405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K8P02_RS11435	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K8P02_RS11440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8P02_RS11455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K8P02_RS11470	COG0686	Belongs to the AlaDH PNT family
K8P02_RS11495	COG1595	DNA-templated transcription, initiation
K8P02_RS11510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K8P02_RS11520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K8P02_RS11545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K8P02_RS11550	COG1741	Belongs to the pirin family
K8P02_RS11555	COG0259	pyridoxamine-phosphate oxidase activity
K8P02_RS11570	COG0346	lactoylglutathione lyase activity
K8P02_RS11585	COG0471	metal ion transport
K8P02_RS11585	COG0490	domain, Protein
K8P02_RS11630	COG1396	sequence-specific DNA binding
K8P02_RS11670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K8P02_RS11670	COG1918	ferrous iron import across plasma membrane
K8P02_RS11675	COG0037	tRNA processing
K8P02_RS11705	COG2198	Histidine kinase
K8P02_RS11705	COG0784	Response regulator, receiver
K8P02_RS11705	COG5002	protein histidine kinase activity
K8P02_RS11710	COG2205	protein histidine kinase activity
K8P02_RS11710	COG2202	Pas domain
K8P02_RS11715	COG0534	Mate efflux family protein
K8P02_RS11720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K8P02_RS11725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K8P02_RS11760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K8P02_RS11785	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8P02_RS11800	COG3119	arylsulfatase activity
K8P02_RS11810	COG3250	beta-galactosidase activity
K8P02_RS11825	COG3250	beta-galactosidase activity
K8P02_RS11830	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS11835	COG3119	arylsulfatase activity
K8P02_RS11840	COG0702	epimerase
K8P02_RS11845	COG4771	TonB-dependent receptor
K8P02_RS11870	COG4771	TonB-dependent receptor
K8P02_RS11890	COG2205	protein histidine kinase activity
K8P02_RS11890	COG3292	Two component regulator propeller
K8P02_RS11890	COG0745	RESPONSE REGULATOR receiver
K8P02_RS11890	COG3292	Two component regulator propeller
K8P02_RS11890	COG2205	protein histidine kinase activity
K8P02_RS11890	COG0745	RESPONSE REGULATOR receiver
K8P02_RS11935	COG3119	arylsulfatase activity
K8P02_RS11940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K8P02_RS11945	COG0668	transmembrane transport
K8P02_RS11950	COG2205	protein histidine kinase activity
K8P02_RS11950	COG3292	Two component regulator propeller
K8P02_RS11950	COG3292	Two component regulator propeller
K8P02_RS11950	COG0745	RESPONSE REGULATOR receiver
K8P02_RS11950	COG2205	protein histidine kinase activity
K8P02_RS11950	COG0745	RESPONSE REGULATOR receiver
K8P02_RS11955	COG3119	arylsulfatase activity
K8P02_RS11965	COG1830	Aldolase
K8P02_RS11970	COG0588	phosphoglycerate mutase activity
K8P02_RS11980	COG1119	ATPase activity
K8P02_RS11985	COG1523	belongs to the glycosyl hydrolase 13 family
K8P02_RS11990	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K8P02_RS12025	COG3023	N-Acetylmuramoyl-L-alanine amidase
K8P02_RS12200	COG0358	DNA primase activity
K8P02_RS12275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K8P02_RS12285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K8P02_RS12290	COG0126	phosphoglycerate kinase activity
K8P02_RS12295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K8P02_RS12295	COG1116	anion transmembrane transporter activity
K8P02_RS12310	COG0424	maF-like protein
K8P02_RS12330	COG0778	Nitroreductase
K8P02_RS12345	COG0288	reversible hydration of carbon dioxide
K8P02_RS12365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K8P02_RS12375	COG0511	ligase activity, forming carbon-carbon bonds
K8P02_RS12375	COG5016	pyruvate
K8P02_RS12380	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K8P02_RS12385	COG0366	Alpha amylase catalytic
K8P02_RS12395	COG0191	fructose-bisphosphate aldolase activity
K8P02_RS12405	COG0254	rRNA binding
K8P02_RS12410	COG5002	protein histidine kinase activity
K8P02_RS12420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K8P02_RS12430	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K8P02_RS12435	COG4206	TonB-dependent receptor
K8P02_RS12435	COG1629	transport
K8P02_RS12445	COG1609	Transcriptional regulator
K8P02_RS12455	COG1554	hydrolase, family 65, central catalytic
K8P02_RS12460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8P02_RS12505	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K8P02_RS12510	COG0511	ligase activity, forming carbon-carbon bonds
K8P02_RS12520	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K8P02_RS12535	COG1280	lysine exporter protein (LysE YggA)
K8P02_RS12545	COG2205	protein histidine kinase activity
K8P02_RS12545	COG0745	RESPONSE REGULATOR receiver
K8P02_RS12545	COG3292	Two component regulator propeller
K8P02_RS12545	COG2205	protein histidine kinase activity
K8P02_RS12545	COG0745	RESPONSE REGULATOR receiver
K8P02_RS12545	COG3292	Two component regulator propeller
K8P02_RS12560	COG1649	PFAM Uncharacterised BCR, COG1649
K8P02_RS12565	COG2198	Histidine kinase
K8P02_RS12565	COG0784	Response regulator, receiver
K8P02_RS12565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8P02_RS12565	COG2205	protein histidine kinase activity
K8P02_RS12605	COG1966	Carbon starvation protein
K8P02_RS12610	COG1649	PFAM Uncharacterised BCR, COG1649
K8P02_RS12630	COG2113	Glycine betaine
K8P02_RS12635	COG4176	ABC-type proline glycine betaine transport system permease component
K8P02_RS12675	COG3292	Two component regulator propeller
K8P02_RS12675	COG2205	protein histidine kinase activity
K8P02_RS12675	COG0745	RESPONSE REGULATOR receiver
K8P02_RS12685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K8P02_RS12685	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K8P02_RS12695	COG1621	beta-fructofuranosidase activity
K8P02_RS12720	COG0702	epimerase
K8P02_RS12725	COG4771	TonB-dependent receptor
K8P02_RS12770	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K8P02_RS12795	COG0484	heat shock protein binding
K8P02_RS12825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS12830	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS12860	COG0702	epimerase
K8P02_RS12865	COG1629	transport
K8P02_RS12915	COG0028	Belongs to the TPP enzyme family
K8P02_RS12920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8P02_RS12925	COG4771	TonB-dependent receptor
K8P02_RS12935	COG0459	protein refolding
K8P02_RS12940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K8P02_RS12945	COG5433	transposase activity
K8P02_RS12970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K8P02_RS12980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K8P02_RS12995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K8P02_RS13020	COG0514	ATP-dependent DNA helicase (RecQ)
K8P02_RS13030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8P02_RS13040	COG0671	phosphoesterase, PA-phosphatase related
K8P02_RS13055	COG0066	3-isopropylmalate dehydratase activity
K8P02_RS13060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K8P02_RS13065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K8P02_RS13105	COG1028	Short-chain dehydrogenase reductase Sdr
K8P02_RS13115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K8P02_RS13120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K8P02_RS13120	COG4651	solute:proton antiporter activity
K8P02_RS13125	COG0439	Biotin carboxylase
K8P02_RS13135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K8P02_RS13170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8P02_RS13175	COG4977	sequence-specific DNA binding
K8P02_RS13195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K8P02_RS13210	COG4804	nuclease activity
K8P02_RS13225	COG1505	serine-type exopeptidase activity
K8P02_RS13235	COG0006	proline dipeptidase activity
K8P02_RS13250	COG0617	tRNA 3'-terminal CCA addition
K8P02_RS13250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K8P02_RS13250	COG0517	IMP dehydrogenase activity
K8P02_RS13260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8P02_RS13265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K8P02_RS13270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K8P02_RS13275	COG0561	phosphatase activity
K8P02_RS13285	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K8P02_RS13290	COG2873	o-acetylhomoserine
K8P02_RS13310	COG4206	TonB-dependent receptor
K8P02_RS13310	COG1629	transport
K8P02_RS13325	COG0632	four-way junction helicase activity
K8P02_RS13330	COG0673	inositol 2-dehydrogenase activity
K8P02_RS13350	COG1272	protein, Hemolysin III
K8P02_RS13355	COG1328	CTP reductase activity
K8P02_RS13355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K8P02_RS13360	COG0602	queuosine metabolic process
K8P02_RS13365	COG2814	Major facilitator Superfamily
K8P02_RS13370	COG1011	Hydrolase
K8P02_RS13375	COG0750	zinc metalloprotease
K8P02_RS13380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K8P02_RS13385	COG0739	heme binding
K8P02_RS13385	COG0741	lytic transglycosylase activity
K8P02_RS13385	COG1196	nuclear chromosome segregation
K8P02_RS13390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K8P02_RS13395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K8P02_RS13405	COG1214	PFAM Peptidase M22, glycoprotease
K8P02_RS13410	COG2205	protein histidine kinase activity
K8P02_RS13425	COG0194	GDP metabolic process
K8P02_RS13430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K8P02_RS13435	COG1408	metallophosphoesterase
K8P02_RS13440	COG1575	Belongs to the MenA family. Type 1 subfamily
K8P02_RS13445	COG1088	dTDP-glucose 4,6-dehydratase activity
K8P02_RS13450	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K8P02_RS13460	COG4771	TonB-dependent receptor
K8P02_RS13475	COG0702	epimerase
K8P02_RS13480	COG4771	TonB-dependent receptor
K8P02_RS13490	COG0745	RESPONSE REGULATOR receiver
K8P02_RS13490	COG2205	protein histidine kinase activity
K8P02_RS13490	COG3292	Two component regulator propeller
K8P02_RS13490	COG0745	RESPONSE REGULATOR receiver
K8P02_RS13490	COG2205	protein histidine kinase activity
K8P02_RS13490	COG3292	Two component regulator propeller
K8P02_RS13525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K8P02_RS13555	COG0702	epimerase
K8P02_RS13560	COG1629	transport
K8P02_RS13565	COG2205	protein histidine kinase activity
K8P02_RS13565	COG0745	RESPONSE REGULATOR receiver
K8P02_RS13565	COG3292	Two component regulator propeller
K8P02_RS13575	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K8P02_RS13575	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K8P02_RS13580	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K8P02_RS13585	COG2985	domain, Protein
K8P02_RS13585	COG0569	domain protein
K8P02_RS13615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K8P02_RS13620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K8P02_RS13625	COG0166	Belongs to the GPI family
K8P02_RS13635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8P02_RS13645	COG2502	aspartate--ammonia ligase
K8P02_RS13650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K8P02_RS13655	COG4771	TonB-dependent receptor
K8P02_RS13685	COG3876	Protein conserved in bacteria
K8P02_RS13690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K8P02_RS13695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K8P02_RS13705	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8P02_RS13715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K8P02_RS13730	COG1640	4-alpha-glucanotransferase
K8P02_RS13755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8P02_RS13760	COG1022	Amp-dependent synthetase and ligase
K8P02_RS13770	COG0359	binds to the 23S rRNA
K8P02_RS13775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K8P02_RS13780	COG0360	Binds together with S18 to 16S ribosomal RNA
K8P02_RS13800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K8P02_RS13805	COG5433	transposase activity
K8P02_RS13810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8P02_RS13850	COG2431	L-lysine efflux transmembrane transporter activity
K8P02_RS13865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K8P02_RS13870	COG1051	belongs to the nudix hydrolase family
K8P02_RS13875	COG0386	Belongs to the glutathione peroxidase family
K8P02_RS13900	COG1396	sequence-specific DNA binding
K8P02_RS13945	COG3023	N-Acetylmuramoyl-L-alanine amidase
K8P02_RS13955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K8P02_RS13965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K8P02_RS13970	COG0658	competence protein
K8P02_RS13975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K8P02_RS13990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K8P02_RS14000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8P02_RS14005	COG0009	L-threonylcarbamoyladenylate synthase
K8P02_RS14015	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K8P02_RS14015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K8P02_RS14020	COG0514	ATP-dependent DNA helicase (RecQ)
K8P02_RS14035	COG0436	Aminotransferase
K8P02_RS14040	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K8P02_RS14050	COG0358	DNA primase activity
K8P02_RS14055	COG0302	gtp cyclohydrolase
K8P02_RS14065	COG0149	triose-phosphate isomerase activity
K8P02_RS14080	COG0739	heme binding
K8P02_RS14085	COG0105	UTP biosynthetic process
K8P02_RS14090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K8P02_RS14095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K8P02_RS14115	COG0811	peptide transport
K8P02_RS14125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K8P02_RS14160	COG0616	signal peptide processing
K8P02_RS14170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K8P02_RS14175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K8P02_RS14190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8P02_RS14210	COG1979	alcohol dehydrogenase
K8P02_RS14225	COG4974	Belongs to the 'phage' integrase family
K8P02_RS14285	COG1082	Xylose isomerase domain protein TIM barrel
K8P02_RS14290	COG1501	Belongs to the glycosyl hydrolase 31 family
K8P02_RS14295	COG1082	Xylose isomerase domain protein TIM barrel
K8P02_RS14315	COG4771	TonB-dependent receptor
K8P02_RS14340	COG1475	DNA binding
K8P02_RS14370	COG0501	Belongs to the peptidase M48B family
K8P02_RS14595	COG2197	response regulator
K8P02_RS14605	COG3973	AAA domain
K8P02_RS14610	COG0039	L-malate dehydrogenase activity
K8P02_RS14640	COG1629	transport
K8P02_RS14640	COG4206	TonB-dependent receptor
K8P02_RS14650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8P02_RS14675	COG1484	DNA-dependent DNA replication
K8P02_RS14680	COG4584	PFAM Integrase catalytic
K8P02_RS14700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8P02_RS14705	COG0489	protein tyrosine kinase activity
K8P02_RS14710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K8P02_RS14720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8P02_RS14730	COG1570	exodeoxyribonuclease VII activity
K8P02_RS14740	COG0482	sulfurtransferase activity
K8P02_RS14760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K8P02_RS14775	COG0179	Fumarylacetoacetate (FAA) hydrolase
K8P02_RS14780	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K8P02_RS14795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K8P02_RS14800	COG0052	Belongs to the universal ribosomal protein uS2 family
K8P02_RS14805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K8P02_RS14810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K8P02_RS14825	COG0017	Asparaginyl-tRNA synthetase
K8P02_RS14830	COG1187	pseudouridine synthase activity
K8P02_RS14850	COG3023	N-Acetylmuramoyl-L-alanine amidase
K8P02_RS14875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K8P02_RS14925	COG0728	peptidoglycan biosynthetic process
K8P02_RS14955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K8P02_RS14960	COG1083	cytidylyl-transferase
K8P02_RS14965	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K8P02_RS14970	COG2089	acid synthase
K8P02_RS14980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K8P02_RS14985	COG1086	Polysaccharide biosynthesis protein
K8P02_RS15020	COG5002	protein histidine kinase activity
K8P02_RS15020	COG3850	Histidine kinase
K8P02_RS15035	COG3022	response to hydroperoxide
K8P02_RS15040	COG3015	lipoprotein NlpE involved in copper resistance
K8P02_RS15055	COG3292	Two component regulator propeller
K8P02_RS15055	COG2205	protein histidine kinase activity
K8P02_RS15055	COG0745	RESPONSE REGULATOR receiver
K8P02_RS15065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K8P02_RS15085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K8P02_RS15110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8P02_RS15115	COG0516	GMP reductase activity
K8P02_RS15115	COG0517	IMP dehydrogenase activity
K8P02_RS15160	COG1629	transport
K8P02_RS15160	COG4206	TonB-dependent receptor
K8P02_RS15165	COG3385	transposase activity
K8P02_RS15170	COG0514	ATP-dependent DNA helicase (RecQ)
K8P02_RS15175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K8P02_RS15180	COG0740	serine-type endopeptidase activity
K8P02_RS15185	COG0544	peptidyl-prolyl cis-trans isomerase activity
K8P02_RS15230	COG0724	RNA recognition motif
K8P02_RS15235	COG0456	acetyltransferase
K8P02_RS15245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K8P02_RS15250	COG1127	ABC transporter
K8P02_RS15255	COG2197	response regulator
K8P02_RS15260	COG1160	GTP binding
K8P02_RS15265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K8P02_RS15270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8P02_RS15285	COG4191	Histidine kinase
K8P02_RS15315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K8P02_RS15320	COG0470	DNA polymerase III
K8P02_RS15325	COG1774	PSP1 C-terminal conserved region
K8P02_RS15335	COG0772	Belongs to the SEDS family
K8P02_RS15360	COG0138	bifunctional purine biosynthesis protein purh
K8P02_RS15365	COG3590	peptidase
K8P02_RS15370	COG0488	(ABC) transporter
K8P02_RS15395	COG2205	protein histidine kinase activity
K8P02_RS15395	COG0784	Response regulator, receiver
K8P02_RS15400	COG0534	Mate efflux family protein
K8P02_RS15405	COG0612	Peptidase, M16
K8P02_RS15430	COG0564	pseudouridine synthase activity
K8P02_RS15465	COG1131	(ABC) transporter
K8P02_RS15545	COG1629	transport
K8P02_RS15570	COG4948	Mandelate Racemase Muconate Lactonizing
K8P02_RS15580	COG1301	dicarboxylic acid transport
K8P02_RS15605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS15610	COG1696	Membrane protein involved in D-alanine export
K8P02_RS15635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8P02_RS15650	COG2986	histidine ammonia-lyase
K8P02_RS15660	COG1228	amidohydrolase
K8P02_RS15670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K8P02_RS15680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K8P02_RS15685	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS15690	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS15715	COG4771	TonB-dependent receptor
K8P02_RS15740	COG3292	Two component regulator propeller
K8P02_RS15740	COG2205	protein histidine kinase activity
K8P02_RS15740	COG0745	RESPONSE REGULATOR receiver
K8P02_RS15755	COG3250	beta-galactosidase activity
K8P02_RS15825	COG3250	beta-galactosidase activity
K8P02_RS15840	COG0203	ribosomal protein L17
K8P02_RS15845	COG0202	RNA polymerase activity
K8P02_RS15850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K8P02_RS15855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K8P02_RS15860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K8P02_RS15865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K8P02_RS15870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K8P02_RS15885	COG0200	Binds to the 23S rRNA
K8P02_RS15890	COG1841	ribosomal large subunit assembly
K8P02_RS15895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K8P02_RS15900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K8P02_RS15905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K8P02_RS15910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K8P02_RS15915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K8P02_RS15920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K8P02_RS15925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K8P02_RS15930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K8P02_RS15935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K8P02_RS15940	COG0255	Belongs to the universal ribosomal protein uL29 family
K8P02_RS15945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K8P02_RS15950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K8P02_RS15960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K8P02_RS15965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K8P02_RS15970	COG0089	rRNA binding
K8P02_RS15975	COG0088	Forms part of the polypeptide exit tunnel
K8P02_RS15980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K8P02_RS15985	COG0051	transcription antitermination factor activity, RNA binding
K8P02_RS15990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K8P02_RS15995	COG0049	tRNA binding
K8P02_RS16000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K8P02_RS16010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K8P02_RS16015	COG0085	RNA polymerase activity
K8P02_RS16020	COG0222	ribosome binding
K8P02_RS16025	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K8P02_RS16030	COG0081	regulation of translation
K8P02_RS16035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K8P02_RS16055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K8P02_RS16080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K8P02_RS16085	COG4974	Belongs to the 'phage' integrase family
K8P02_RS16090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K8P02_RS16095	COG0006	proline dipeptidase activity
K8P02_RS16100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K8P02_RS16110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K8P02_RS16160	COG4206	TonB-dependent receptor
K8P02_RS16160	COG1629	transport
K8P02_RS16170	COG5492	domain, Protein
K8P02_RS16175	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS16185	COG3250	beta-galactosidase activity
K8P02_RS16190	COG0673	inositol 2-dehydrogenase activity
K8P02_RS16195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K8P02_RS16205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K8P02_RS16230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K8P02_RS16245	COG1785	Belongs to the alkaline phosphatase family
K8P02_RS16250	COG3420	alginic acid biosynthetic process
K8P02_RS16270	COG4206	TonB-dependent receptor
K8P02_RS16270	COG1629	transport
K8P02_RS16280	COG1027	Aspartate ammonia-lyase
K8P02_RS16285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K8P02_RS16290	COG0252	asparaginase activity
K8P02_RS16305	COG2096	Adenosyltransferase
K8P02_RS16345	COG3345	alpha-galactosidase
K8P02_RS16355	COG4974	Belongs to the 'phage' integrase family
K8P02_RS16360	COG4804	nuclease activity
K8P02_RS16380	COG0546	phosphoglycolate phosphatase activity
K8P02_RS16480	COG1629	transport
K8P02_RS16480	COG4206	TonB-dependent receptor
K8P02_RS16495	COG4974	Belongs to the 'phage' integrase family
K8P02_RS16515	COG1082	Xylose isomerase domain protein TIM barrel
K8P02_RS16520	COG1082	Xylose isomerase domain protein TIM barrel
K8P02_RS16540	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K8P02_RS16545	COG4771	TonB-dependent receptor
K8P02_RS16645	COG3385	transposase activity
K8P02_RS16660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K8P02_RS16670	COG1185	polyribonucleotide nucleotidyltransferase activity
K8P02_RS16685	COG4206	TonB-dependent receptor
K8P02_RS16685	COG1629	transport
K8P02_RS16695	COG3426	butyrate kinase activity
K8P02_RS16700	COG0280	phosphate acetyltransferase
K8P02_RS16705	COG1619	proteins homologs of microcin C7 resistance protein MccF
K8P02_RS16710	COG2234	aminopeptidase activity
K8P02_RS16715	COG2166	iron-sulfur cluster assembly
K8P02_RS16750	COG3537	Alpha-1,2-mannosidase
K8P02_RS16770	COG3655	Transcriptional regulator
K8P02_RS16790	COG1266	CAAX protease self-immunity
K8P02_RS16810	COG0196	riboflavin kinase activity
K8P02_RS16815	COG1011	Hydrolase
K8P02_RS16820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K8P02_RS16835	COG1283	sodium-dependent phosphate transmembrane transporter activity
K8P02_RS16845	COG2205	protein histidine kinase activity
K8P02_RS16850	COG0006	proline dipeptidase activity
K8P02_RS16865	COG0509	glycine decarboxylation via glycine cleavage system
K8P02_RS16870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K8P02_RS16875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K8P02_RS16890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8P02_RS16905	COG1040	competence protein
K8P02_RS16915	COG5492	domain, Protein
K8P02_RS16955	COG3634	alkyl hydroperoxide reductase activity
K8P02_RS17000	COG0018	arginyl-trna synthetase
K8P02_RS17025	COG0339	signal peptide processing
K8P02_RS17030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8P02_RS17045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K8P02_RS17045	COG0674	pyruvate-flavodoxin oxidoreductase activity
K8P02_RS17050	COG1013	pyruvate-flavodoxin oxidoreductase activity
K8P02_RS17055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K8P02_RS17060	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K8P02_RS17085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K8P02_RS17090	COG1396	sequence-specific DNA binding
K8P02_RS17095	COG0318	PFAM AMP-dependent synthetase and ligase
K8P02_RS17105	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
K8P02_RS17105	COG3408	Glycogen debranching enzyme
K8P02_RS17110	COG3250	beta-galactosidase activity
K8P02_RS17115	COG2431	L-lysine efflux transmembrane transporter activity
K8P02_RS17125	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
K8P02_RS17125	COG3408	Glycogen debranching enzyme
K8P02_RS17145	COG1629	transport
K8P02_RS17145	COG4206	TonB-dependent receptor
K8P02_RS17155	COG4999	Histidine kinase
K8P02_RS17155	COG2205	protein histidine kinase activity
K8P02_RS17155	COG3850	Histidine kinase
K8P02_RS17155	COG3437	response regulator, receiver
K8P02_RS17170	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS17190	COG4771	TonB-dependent receptor
K8P02_RS17230	COG4974	Belongs to the 'phage' integrase family
K8P02_RS17245	COG0457	Tetratricopeptide repeat
K8P02_RS17250	COG2814	Major facilitator Superfamily
K8P02_RS17255	COG2205	protein histidine kinase activity
K8P02_RS17255	COG0745	RESPONSE REGULATOR receiver
K8P02_RS17255	COG2205	protein histidine kinase activity
K8P02_RS17255	COG3292	Two component regulator propeller
K8P02_RS17255	COG3292	Two component regulator propeller
K8P02_RS17255	COG0745	RESPONSE REGULATOR receiver
K8P02_RS17305	COG4948	Mandelate Racemase Muconate Lactonizing
K8P02_RS17315	COG5002	protein histidine kinase activity
K8P02_RS17315	COG2198	Histidine kinase
K8P02_RS17315	COG0784	Response regulator, receiver
K8P02_RS17325	COG4999	Histidine kinase
K8P02_RS17325	COG3850	Histidine kinase
K8P02_RS17325	COG3437	response regulator, receiver
K8P02_RS17325	COG2205	protein histidine kinase activity
K8P02_RS17330	COG0745	RESPONSE REGULATOR receiver
K8P02_RS17375	COG4591	ABC-type transport system involved in lipoprotein release permease component
K8P02_RS17380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K8P02_RS17400	COG4974	Belongs to the 'phage' integrase family
K8P02_RS17420	COG3459	Glycosyltransferase 36 associated
K8P02_RS17445	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS17465	COG1629	transport
K8P02_RS17480	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K8P02_RS17485	COG0745	RESPONSE REGULATOR receiver
K8P02_RS17485	COG3292	Two component regulator propeller
K8P02_RS17485	COG2205	protein histidine kinase activity
K8P02_RS17490	COG0606	chelatase, subunit chli
K8P02_RS17560	COG2244	polysaccharide biosynthetic process
K8P02_RS17565	COG1215	transferase activity, transferring glycosyl groups
K8P02_RS17580	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS17590	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K8P02_RS17595	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS17610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K8P02_RS17615	COG0545	Peptidyl-prolyl cis-trans isomerase
K8P02_RS17620	COG0545	Peptidyl-prolyl cis-trans isomerase
K8P02_RS17680	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS17685	COG4948	Mandelate Racemase Muconate Lactonizing
K8P02_RS17690	COG3661	Belongs to the glycosyl hydrolase 67 family
K8P02_RS17700	COG3250	beta-galactosidase activity
K8P02_RS17705	COG1053	succinate dehydrogenase
K8P02_RS17725	COG0745	RESPONSE REGULATOR receiver
K8P02_RS17725	COG2205	protein histidine kinase activity
K8P02_RS17725	COG3292	Two component regulator propeller
K8P02_RS17745	COG0702	epimerase
K8P02_RS17750	COG1629	transport
K8P02_RS17765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K8P02_RS17770	COG3409	Peptidoglycan-binding domain 1 protein
K8P02_RS17770	COG0793	Belongs to the peptidase S41A family
K8P02_RS17775	COG0671	phosphoesterase, PA-phosphatase related
K8P02_RS17790	COG1053	succinate dehydrogenase
K8P02_RS17795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K8P02_RS17820	COG1629	transport
K8P02_RS17820	COG4206	TonB-dependent receptor
K8P02_RS17870	COG0826	peptidase U32
K8P02_RS17875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8P02_RS17925	COG1940	carbohydrate kinase activity
K8P02_RS17945	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K8P02_RS17950	COG0557	exoribonuclease II activity
K8P02_RS17960	COG1595	DNA-templated transcription, initiation
K8P02_RS17970	COG1629	transport
K8P02_RS17970	COG4206	TonB-dependent receptor
K8P02_RS18015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8P02_RS18020	COG0738	Major facilitator superfamily
K8P02_RS18040	COG2610	gluconate transmembrane transporter activity
K8P02_RS18055	COG1785	Belongs to the alkaline phosphatase family
K8P02_RS18075	COG0702	epimerase
K8P02_RS18080	COG1629	transport
K8P02_RS18100	COG0012	GTP binding
K8P02_RS18105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K8P02_RS18110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K8P02_RS18120	COG1028	Short-chain dehydrogenase reductase Sdr
K8P02_RS18125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K8P02_RS18140	COG4452	Inner membrane protein CreD
K8P02_RS18175	COG0495	leucyl-tRNA aminoacylation
K8P02_RS18180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8P02_RS18190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K8P02_RS18205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K8P02_RS18225	COG0731	radical SAM domain protein
K8P02_RS18225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K8P02_RS18230	COG0659	secondary active sulfate transmembrane transporter activity
K8P02_RS18235	COG1592	Rubrerythrin
K8P02_RS18240	COG3292	Two component regulator propeller
K8P02_RS18240	COG2205	protein histidine kinase activity
K8P02_RS18240	COG0745	RESPONSE REGULATOR receiver
K8P02_RS18245	COG0702	epimerase
K8P02_RS18250	COG1629	transport
K8P02_RS18260	COG4771	TonB-dependent receptor
K8P02_RS18285	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS18295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K8P02_RS18330	COG0702	epimerase
K8P02_RS18335	COG1629	transport
K8P02_RS18340	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS18460	COG1629	transport
K8P02_RS18495	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS18520	COG0702	epimerase
K8P02_RS18525	COG4771	TonB-dependent receptor
K8P02_RS18545	COG2814	Major facilitator Superfamily
K8P02_RS18555	COG0427	acetyl-CoA hydrolase
K8P02_RS18565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8P02_RS18575	COG3458	cephalosporin-C deacetylase activity
K8P02_RS18580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K8P02_RS18585	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K8P02_RS18600	COG2271	Major facilitator Superfamily
K8P02_RS18615	COG0702	epimerase
K8P02_RS18620	COG4771	TonB-dependent receptor
K8P02_RS18640	COG2177	Part of the ABC transporter FtsEX involved in
K8P02_RS18650	COG1968	undecaprenyl-diphosphatase activity
K8P02_RS18655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K8P02_RS18660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K8P02_RS18665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K8P02_RS18675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K8P02_RS18720	COG1611	Belongs to the LOG family
K8P02_RS18735	COG0594	ribonuclease P activity
K8P02_RS18740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K8P02_RS18750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K8P02_RS18770	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K8P02_RS18775	COG1028	Short-chain dehydrogenase reductase Sdr
K8P02_RS18780	COG4677	pectinesterase activity
K8P02_RS18785	COG3119	arylsulfatase activity
K8P02_RS18790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K8P02_RS18815	COG1121	(ABC) transporter
K8P02_RS18825	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K8P02_RS18825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8P02_RS18845	COG1506	peptidase
K8P02_RS18845	COG0823	Involved in the tonB-independent uptake of proteins
K8P02_RS18850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K8P02_RS18850	COG0116	Belongs to the methyltransferase superfamily
K8P02_RS18855	COG1045	serine acetyltransferase
K8P02_RS18860	COG3275	phosphorelay sensor kinase activity
K8P02_RS18865	COG3279	Response regulator of the LytR AlgR family
K8P02_RS18880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8P02_RS18880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8P02_RS18885	COG0142	geranyltranstransferase activity
K8P02_RS18895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K8P02_RS18900	COG1694	Mazg nucleotide pyrophosphohydrolase
K8P02_RS18905	COG1490	D-aminoacyl-tRNA deacylase activity
K8P02_RS18910	COG0322	excinuclease ABC activity
K8P02_RS18915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K8P02_RS19005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K8P02_RS19010	COG2715	membrane protein required for spore maturation
K8P02_RS19020	COG2255	four-way junction helicase activity
K8P02_RS19040	COG3591	Belongs to the peptidase S1B family
K8P02_RS19085	COG0612	Peptidase, M16
K8P02_RS19090	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS19095	COG3401	FG-GAP repeat protein
K8P02_RS19110	COG0681	Belongs to the peptidase S26 family
K8P02_RS19120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K8P02_RS19145	COG2755	lipolytic protein G-D-S-L family
K8P02_RS19145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K8P02_RS19155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8P02_RS19160	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K8P02_RS19170	COG4771	TonB-dependent receptor
K8P02_RS19180	COG5492	domain, Protein
K8P02_RS19250	COG3119	arylsulfatase activity
K8P02_RS19255	COG3292	Two component regulator propeller
K8P02_RS19255	COG2205	protein histidine kinase activity
K8P02_RS19255	COG0745	RESPONSE REGULATOR receiver
K8P02_RS19270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8P02_RS19285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8P02_RS19305	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS19310	COG3119	arylsulfatase activity
K8P02_RS19315	COG0215	cysteine-tRNA ligase activity
K8P02_RS19320	COG0561	phosphatase activity
K8P02_RS19345	COG0205	6-phosphofructokinase activity
K8P02_RS19355	COG0571	ribonuclease III activity
K8P02_RS19360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K8P02_RS19365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8P02_RS19370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K8P02_RS19380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K8P02_RS19385	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS19395	COG0859	PFAM glycosyl transferase family 9
K8P02_RS19400	COG0463	Glycosyl transferase, family 2
K8P02_RS19415	COG0438	transferase activity, transferring glycosyl groups
K8P02_RS19440	COG1442	glycosyl transferase family 8
K8P02_RS19445	COG1216	Glycosyl transferase, family 2
K8P02_RS19465	COG1132	(ABC) transporter
K8P02_RS19475	COG3341	Caulimovirus viroplasmin
K8P02_RS19475	COG0328	RNA-DNA hybrid ribonuclease activity
K8P02_RS19485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K8P02_RS19490	COG1166	arginine decarboxylase activity
K8P02_RS19495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K8P02_RS19500	COG1595	DNA-templated transcription, initiation
K8P02_RS19540	COG0235	Class ii aldolase
K8P02_RS19545	COG1070	Carbohydrate kinase
K8P02_RS19555	COG0738	Major facilitator superfamily
K8P02_RS19590	COG2205	protein histidine kinase activity
K8P02_RS19590	COG0745	RESPONSE REGULATOR receiver
K8P02_RS19590	COG3292	Two component regulator propeller
K8P02_RS19590	COG0745	RESPONSE REGULATOR receiver
K8P02_RS19590	COG3292	Two component regulator propeller
K8P02_RS19590	COG2205	protein histidine kinase activity
K8P02_RS19600	COG1629	transport
K8P02_RS19605	COG0702	epimerase
K8P02_RS19610	COG5492	domain, Protein
K8P02_RS19630	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS19635	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K8P02_RS19640	COG0779	Required for maturation of 30S ribosomal subunits
K8P02_RS19645	COG0195	Participates in both transcription termination and antitermination
K8P02_RS19650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K8P02_RS19660	COG0719	Fe-S assembly protein
K8P02_RS19665	COG0396	ATPase activity
K8P02_RS19670	COG0719	Fe-S assembly protein
K8P02_RS19675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K8P02_RS19685	COG0393	Putative heavy-metal-binding
K8P02_RS19695	COG4804	nuclease activity
K8P02_RS19705	COG2217	Heavy metal translocating P-type atpase
K8P02_RS19710	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K8P02_RS19715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K8P02_RS19735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K8P02_RS19745	COG0187	DNA topoisomerase II activity
K8P02_RS19750	COG0268	Binds directly to 16S ribosomal RNA
K8P02_RS19760	COG1381	Involved in DNA repair and RecF pathway recombination
K8P02_RS19775	COG0702	epimerase
K8P02_RS19780	COG4771	TonB-dependent receptor
K8P02_RS19790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K8P02_RS19805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K8P02_RS19810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K8P02_RS19815	COG0772	Belongs to the SEDS family
K8P02_RS19820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K8P02_RS19825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8P02_RS19830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K8P02_RS19855	COG5433	transposase activity
K8P02_RS19920	COG2376	Dihydroxyacetone kinase
K8P02_RS19925	COG2376	Dihydroxyacetone kinase
K8P02_RS19935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8P02_RS19935	COG1333	cytochrome c biogenesis protein
K8P02_RS19960	COG1414	Transcriptional regulator
K8P02_RS19965	COG1595	DNA-templated transcription, initiation
K8P02_RS19980	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K8P02_RS19985	COG0756	dUTP diphosphatase activity
K8P02_RS20000	COG4942	peptidase
K8P02_RS20015	COG2017	converts alpha-aldose to the beta-anomer
K8P02_RS20025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8P02_RS20030	COG1022	Amp-dependent synthetase and ligase
K8P02_RS20045	COG3292	Two component regulator propeller
K8P02_RS20045	COG2205	protein histidine kinase activity
K8P02_RS20045	COG0745	RESPONSE REGULATOR receiver
K8P02_RS20050	COG3537	Alpha-1,2-mannosidase
K8P02_RS20065	COG1629	transport
K8P02_RS20070	COG0702	epimerase
K8P02_RS20090	COG0612	Peptidase, M16
K8P02_RS20105	COG2954	triphosphatase activity
K8P02_RS20175	COG0702	epimerase
K8P02_RS20180	COG4771	TonB-dependent receptor
K8P02_RS20210	COG0423	glycine-tRNA ligase activity
K8P02_RS20230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K8P02_RS20235	COG0439	Biotin carboxylase
K8P02_RS20240	COG0511	ligase activity, forming carbon-carbon bonds
K8P02_RS20250	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K8P02_RS20260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8P02_RS20355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K8P02_RS20370	COG0277	FAD linked oxidase domain protein
K8P02_RS20375	COG3876	Protein conserved in bacteria
K8P02_RS20395	COG1215	transferase activity, transferring glycosyl groups
K8P02_RS20405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8P02_RS20410	COG3876	Protein conserved in bacteria
K8P02_RS20430	COG1629	transport
K8P02_RS20450	COG1649	PFAM Uncharacterised BCR, COG1649
K8P02_RS20460	COG1629	transport
K8P02_RS20460	COG4206	TonB-dependent receptor
K8P02_RS20480	COG1649	PFAM Uncharacterised BCR, COG1649
K8P02_RS20530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K8P02_RS20535	COG0475	glutathione-regulated potassium exporter activity
K8P02_RS20535	COG0589	response to stress
K8P02_RS20540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K8P02_RS20545	COG1136	(ABC) transporter
K8P02_RS20555	COG0733	neurotransmitter:sodium symporter activity
K8P02_RS20565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K8P02_RS20570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K8P02_RS20575	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K8P02_RS20580	COG0312	modulator of DNA gyrase
K8P02_RS20585	COG0312	modulator of DNA gyrase
K8P02_RS20600	COG1346	cytolysis
K8P02_RS20605	COG1380	Effector of murein hydrolase LrgA
K8P02_RS20625	COG0280	phosphate acetyltransferase
K8P02_RS20630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K8P02_RS20635	COG1216	Glycosyl transferase, family 2
K8P02_RS20635	COG0463	Glycosyl transferase, family 2
K8P02_RS20640	COG2003	Belongs to the UPF0758 family
K8P02_RS20665	COG2151	metal-sulfur cluster biosynthetic enzyme
K8P02_RS20670	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8P02_RS20680	COG1785	Belongs to the alkaline phosphatase family
K8P02_RS20685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K8P02_RS20690	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K8P02_RS20700	COG0564	pseudouridine synthase activity
K8P02_RS20715	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K8P02_RS20730	COG2205	protein histidine kinase activity
K8P02_RS20745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K8P02_RS20750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K8P02_RS20755	COG0436	Aminotransferase
K8P02_RS20765	COG0784	Response regulator, receiver
K8P02_RS20765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8P02_RS20765	COG2198	Histidine kinase
K8P02_RS20765	COG2205	protein histidine kinase activity
K8P02_RS20775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K8P02_RS20795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K8P02_RS20810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8P02_RS20810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8P02_RS20815	COG2890	protein-(glutamine-N5) methyltransferase activity
K8P02_RS20825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K8P02_RS20835	COG0165	Argininosuccinate lyase
K8P02_RS20855	COG1704	LemA family
K8P02_RS20880	COG3594	Acyltransferase
K8P02_RS20890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K8P02_RS20895	COG1396	sequence-specific DNA binding
K8P02_RS20895	COG1917	Cupin 2, conserved barrel domain protein
K8P02_RS20900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8P02_RS20910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K8P02_RS20920	COG1983	PspC domain protein
K8P02_RS20925	COG0137	argininosuccinate synthase activity
K8P02_RS20970	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8P02_RS20980	COG3401	FG-GAP repeat protein
K8P02_RS20985	COG2382	esterase
K8P02_RS20985	COG3507	Belongs to the glycosyl hydrolase 43 family
K8P02_RS20985	COG3693	PFAM glycoside hydrolase, family 10
K8P02_RS21000	COG1070	Carbohydrate kinase
K8P02_RS21005	COG4806	L-rhamnose isomerase
K8P02_RS21015	COG0235	Class ii aldolase
K8P02_RS21045	COG4771	TonB-dependent receptor
K8P02_RS21050	COG0702	epimerase
K8P02_RS21065	COG4771	TonB-dependent receptor
K8P02_RS21075	COG3401	FG-GAP repeat protein
K8P02_RS21080	COG3250	beta-galactosidase activity
K8P02_RS21090	COG1629	transport
K8P02_RS21095	COG0702	epimerase
K8P02_RS21110	COG1454	alcohol dehydrogenase
K8P02_RS21120	COG3340	Belongs to the peptidase S51 family
K8P02_RS21125	COG2378	regulation of single-species biofilm formation
K8P02_RS21195	COG4974	Belongs to the 'phage' integrase family
K8P02_RS21210	COG0531	amino acid
K8P02_RS21220	COG2066	Belongs to the glutaminase family
K8P02_RS21225	COG0076	glutamate decarboxylase activity
K8P02_RS21255	COG0039	L-malate dehydrogenase activity
K8P02_RS21260	COG2996	Protein conserved in bacteria
K8P02_RS21305	COG1216	Glycosyl transferase, family 2
K8P02_RS21330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8P02_RS21335	COG0577	efflux transmembrane transporter activity
K8P02_RS21335	COG1136	(ABC) transporter
K8P02_RS21345	COG1136	(ABC) transporter
K8P02_RS21350	COG1940	carbohydrate kinase activity
K8P02_RS21375	COG4206	TonB-dependent receptor
K8P02_RS21375	COG1629	transport
K8P02_RS21385	COG1595	DNA-templated transcription, initiation
K8P02_RS21390	COG0335	large ribosomal subunit rRNA binding
K8P02_RS21395	COG0737	Belongs to the 5'-nucleotidase family
K8P02_RS21400	COG0737	Belongs to the 5'-nucleotidase family
K8P02_RS21405	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS21410	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS21435	COG0446	pyridine nucleotide-disulphide oxidoreductase
K8P02_RS21440	COG2204	response regulator
K8P02_RS21450	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K8P02_RS21460	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K8P02_RS21470	COG2205	protein histidine kinase activity
K8P02_RS21475	COG5002	protein histidine kinase activity
K8P02_RS21540	COG4771	TonB-dependent receptor
K8P02_RS21545	COG0519	Catalyzes the synthesis of GMP from XMP
K8P02_RS21565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8P02_RS21565	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8P02_RS21570	COG0436	Aminotransferase
K8P02_RS21595	COG0826	peptidase U32
K8P02_RS21610	COG4771	TonB-dependent receptor
K8P02_RS21620	COG0671	phosphoesterase, PA-phosphatase related
K8P02_RS21635	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K8P02_RS21645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K8P02_RS21650	COG0252	asparaginase activity
K8P02_RS21660	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
K8P02_RS21665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K8P02_RS21685	COG0668	transmembrane transport
K8P02_RS21690	COG1472	Belongs to the glycosyl hydrolase 3 family
K8P02_RS21700	COG0534	Mate efflux family protein
K8P02_RS21730	COG0628	permease
K8P02_RS21735	COG1435	thymidine kinase activity
K8P02_RS21745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K8P02_RS21760	COG2095	MarC family integral membrane protein