locus-tag	class	description
K6V19_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6V19_RS00010	COG0778	Nitroreductase
K6V19_RS00020	COG1640	4-alpha-glucanotransferase
K6V19_RS00030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6V19_RS00050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V19_RS00055	COG1022	Amp-dependent synthetase and ligase
K6V19_RS00065	COG0359	binds to the 23S rRNA
K6V19_RS00070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6V19_RS00075	COG0360	Binds together with S18 to 16S ribosomal RNA
K6V19_RS00100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V19_RS00125	COG0745	RESPONSE REGULATOR receiver
K6V19_RS00125	COG2205	protein histidine kinase activity
K6V19_RS00125	COG3292	Two component regulator propeller
K6V19_RS00130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6V19_RS00165	COG2431	L-lysine efflux transmembrane transporter activity
K6V19_RS00180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V19_RS00185	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K6V19_RS00190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V19_RS00200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6V19_RS00210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6V19_RS00225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6V19_RS00235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V19_RS00240	COG0009	L-threonylcarbamoyladenylate synthase
K6V19_RS00250	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K6V19_RS00250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6V19_RS00255	COG0514	ATP-dependent DNA helicase (RecQ)
K6V19_RS00270	COG0436	Aminotransferase
K6V19_RS00275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K6V19_RS00290	COG0358	DNA primase activity
K6V19_RS00295	COG0302	gtp cyclohydrolase
K6V19_RS00305	COG0149	triose-phosphate isomerase activity
K6V19_RS00320	COG0739	heme binding
K6V19_RS00325	COG0105	UTP biosynthetic process
K6V19_RS00330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6V19_RS00335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6V19_RS00355	COG0811	peptide transport
K6V19_RS00365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6V19_RS00405	COG0616	signal peptide processing
K6V19_RS00415	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6V19_RS00420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6V19_RS00440	COG4983	Phage plasmid primase, P4 family domain protein
K6V19_RS00500	COG3328	transposase activity
K6V19_RS00570	COG0546	phosphoglycolate phosphatase activity
K6V19_RS00575	COG0110	maltose O-acetyltransferase activity
K6V19_RS00600	COG3275	phosphorelay sensor kinase activity
K6V19_RS00620	COG0039	L-malate dehydrogenase activity
K6V19_RS00635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V19_RS00650	COG3119	arylsulfatase activity
K6V19_RS00650	COG3408	Glycogen debranching enzyme
K6V19_RS00655	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V19_RS00660	COG3250	beta-galactosidase activity
K6V19_RS00665	COG1082	Xylose isomerase domain protein TIM barrel
K6V19_RS00670	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V19_RS00675	COG4124	Belongs to the glycosyl hydrolase 26 family
K6V19_RS00685	COG1629	transport
K6V19_RS00690	COG0702	epimerase
K6V19_RS00710	COG3458	cephalosporin-C deacetylase activity
K6V19_RS00735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V19_RS00740	COG0489	protein tyrosine kinase activity
K6V19_RS00745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6V19_RS00755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6V19_RS00765	COG1570	exodeoxyribonuclease VII activity
K6V19_RS00775	COG0482	sulfurtransferase activity
K6V19_RS00795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6V19_RS00805	COG2957	Belongs to the agmatine deiminase family
K6V19_RS00810	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6V19_RS00815	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K6V19_RS00830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6V19_RS00835	COG0052	Belongs to the universal ribosomal protein uS2 family
K6V19_RS00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6V19_RS00845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6V19_RS00855	COG0017	Asparaginyl-tRNA synthetase
K6V19_RS00860	COG1187	pseudouridine synthase activity
K6V19_RS00880	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V19_RS00895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V19_RS00905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V19_RS00920	COG0110	maltose O-acetyltransferase activity
K6V19_RS00940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K6V19_RS00945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V19_RS00970	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6V19_RS00975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V19_RS00980	COG0489	protein tyrosine kinase activity
K6V19_RS00980	COG3206	protein involved in exopolysaccharide biosynthesis
K6V19_RS01010	COG0110	maltose O-acetyltransferase activity
K6V19_RS01015	COG3022	response to hydroperoxide
K6V19_RS01020	COG3015	lipoprotein NlpE involved in copper resistance
K6V19_RS01035	COG2755	lipolytic protein G-D-S-L family
K6V19_RS01035	COG0657	acetylesterase activity
K6V19_RS01060	COG3250	beta-galactosidase activity
K6V19_RS01070	COG3537	Alpha-1,2-mannosidase
K6V19_RS01080	COG4771	TonB-dependent receptor
K6V19_RS01100	COG2205	protein histidine kinase activity
K6V19_RS01100	COG3292	Two component regulator propeller
K6V19_RS01100	COG0745	RESPONSE REGULATOR receiver
K6V19_RS01105	COG0383	alpha-mannosidase activity
K6V19_RS01110	COG3250	beta-galactosidase activity
K6V19_RS01120	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS01135	COG1082	Xylose isomerase domain protein TIM barrel
K6V19_RS01140	COG0745	RESPONSE REGULATOR receiver
K6V19_RS01140	COG3292	Two component regulator propeller
K6V19_RS01140	COG2205	protein histidine kinase activity
K6V19_RS01140	COG0745	RESPONSE REGULATOR receiver
K6V19_RS01140	COG3292	Two component regulator propeller
K6V19_RS01140	COG2205	protein histidine kinase activity
K6V19_RS01165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6V19_RS01190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6V19_RS01195	COG0516	GMP reductase activity
K6V19_RS01195	COG0517	IMP dehydrogenase activity
K6V19_RS01200	COG0514	ATP-dependent DNA helicase (RecQ)
K6V19_RS01205	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6V19_RS01210	COG0740	serine-type endopeptidase activity
K6V19_RS01215	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6V19_RS01220	COG0724	RNA recognition motif
K6V19_RS01225	COG0456	acetyltransferase
K6V19_RS01235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6V19_RS01240	COG1127	ABC transporter
K6V19_RS01245	COG2197	response regulator
K6V19_RS01250	COG1160	GTP binding
K6V19_RS01255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6V19_RS01260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V19_RS01275	COG4191	Histidine kinase
K6V19_RS01310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6V19_RS01315	COG0470	DNA polymerase III
K6V19_RS01320	COG1774	PSP1 C-terminal conserved region
K6V19_RS01330	COG0772	Belongs to the SEDS family
K6V19_RS01355	COG0138	bifunctional purine biosynthesis protein purh
K6V19_RS01360	COG3590	peptidase
K6V19_RS01365	COG0488	(ABC) transporter
K6V19_RS01370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V19_RS01390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V19_RS01390	COG2205	protein histidine kinase activity
K6V19_RS01395	COG0534	Mate efflux family protein
K6V19_RS01400	COG0612	Peptidase, M16
K6V19_RS01410	COG2204	response regulator
K6V19_RS01425	COG0564	pseudouridine synthase activity
K6V19_RS01545	COG1629	transport
K6V19_RS01570	COG4948	Mandelate Racemase Muconate Lactonizing
K6V19_RS01580	COG1301	dicarboxylic acid transport
K6V19_RS01590	COG0366	Alpha amylase catalytic
K6V19_RS01605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS01610	COG1696	Membrane protein involved in D-alanine export
K6V19_RS01635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V19_RS01650	COG2986	histidine ammonia-lyase
K6V19_RS01660	COG1228	amidohydrolase
K6V19_RS01670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6V19_RS01680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V19_RS01695	COG0203	ribosomal protein L17
K6V19_RS01700	COG0202	RNA polymerase activity
K6V19_RS01705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6V19_RS01710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6V19_RS01715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6V19_RS01720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6V19_RS01725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6V19_RS01740	COG0200	Binds to the 23S rRNA
K6V19_RS01745	COG1841	ribosomal large subunit assembly
K6V19_RS01750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6V19_RS01755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6V19_RS01760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6V19_RS01765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6V19_RS01770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6V19_RS01775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6V19_RS01780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6V19_RS01785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6V19_RS01790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6V19_RS01795	COG0255	Belongs to the universal ribosomal protein uL29 family
K6V19_RS01800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6V19_RS01805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6V19_RS01815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6V19_RS01820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6V19_RS01825	COG0089	rRNA binding
K6V19_RS01830	COG0088	Forms part of the polypeptide exit tunnel
K6V19_RS01835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6V19_RS01840	COG0051	transcription antitermination factor activity, RNA binding
K6V19_RS01845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V19_RS01850	COG0049	tRNA binding
K6V19_RS01855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K6V19_RS01880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6V19_RS01885	COG0085	RNA polymerase activity
K6V19_RS01890	COG0222	ribosome binding
K6V19_RS01895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6V19_RS01900	COG0081	regulation of translation
K6V19_RS01905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6V19_RS01925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6V19_RS01950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6V19_RS01955	COG4974	Belongs to the 'phage' integrase family
K6V19_RS01960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6V19_RS01965	COG0006	proline dipeptidase activity
K6V19_RS01970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6V19_RS01980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V19_RS01995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6V19_RS02005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6V19_RS02030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6V19_RS02040	COG1027	Aspartate ammonia-lyase
K6V19_RS02045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6V19_RS02050	COG0252	asparaginase activity
K6V19_RS02065	COG2096	Adenosyltransferase
K6V19_RS02095	COG0463	Glycosyl transferase, family 2
K6V19_RS02150	COG0537	adenosine 5'-monophosphoramidase activity
K6V19_RS02155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6V19_RS02165	COG1185	polyribonucleotide nucleotidyltransferase activity
K6V19_RS02180	COG4206	TonB-dependent receptor
K6V19_RS02180	COG1629	transport
K6V19_RS02195	COG2818	Glycosylase
K6V19_RS02200	COG3426	butyrate kinase activity
K6V19_RS02205	COG0280	phosphate acetyltransferase
K6V19_RS02210	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6V19_RS02215	COG2234	aminopeptidase activity
K6V19_RS02220	COG2166	iron-sulfur cluster assembly
K6V19_RS02255	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS02270	COG0702	epimerase
K6V19_RS02275	COG4206	TonB-dependent receptor
K6V19_RS02275	COG1629	transport
K6V19_RS02285	COG2017	converts alpha-aldose to the beta-anomer
K6V19_RS02290	COG0457	Tetratricopeptide repeat
K6V19_RS02295	COG2814	Major facilitator Superfamily
K6V19_RS02300	COG0745	RESPONSE REGULATOR receiver
K6V19_RS02300	COG3292	Two component regulator propeller
K6V19_RS02300	COG2205	protein histidine kinase activity
K6V19_RS02325	COG4948	Mandelate Racemase Muconate Lactonizing
K6V19_RS02345	COG3655	Transcriptional regulator
K6V19_RS02370	COG0196	riboflavin kinase activity
K6V19_RS02375	COG1011	Hydrolase
K6V19_RS02380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6V19_RS02390	COG1773	rubredoxin
K6V19_RS02395	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6V19_RS02400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6V19_RS02405	COG2205	protein histidine kinase activity
K6V19_RS02410	COG0006	proline dipeptidase activity
K6V19_RS02425	COG0509	glycine decarboxylation via glycine cleavage system
K6V19_RS02430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6V19_RS02435	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6V19_RS02450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6V19_RS02485	COG1040	competence protein
K6V19_RS02490	COG0483	inositol monophosphate 1-phosphatase activity
K6V19_RS02495	COG5492	domain, Protein
K6V19_RS02510	COG2816	NAD+ diphosphatase activity
K6V19_RS02515	COG3118	belongs to the thioredoxin family
K6V19_RS02555	COG0018	arginyl-trna synthetase
K6V19_RS02580	COG0339	signal peptide processing
K6V19_RS02585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6V19_RS02590	COG1629	transport
K6V19_RS02590	COG4206	TonB-dependent receptor
K6V19_RS02610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6V19_RS02610	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6V19_RS02615	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6V19_RS02620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6V19_RS02625	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6V19_RS02665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6V19_RS02670	COG1396	sequence-specific DNA binding
K6V19_RS02675	COG0318	PFAM AMP-dependent synthetase and ligase
K6V19_RS02680	COG3850	Histidine kinase
K6V19_RS02680	COG4999	Histidine kinase
K6V19_RS02680	COG2205	protein histidine kinase activity
K6V19_RS02680	COG3437	response regulator, receiver
K6V19_RS02715	COG2205	protein histidine kinase activity
K6V19_RS02715	COG3437	response regulator, receiver
K6V19_RS02715	COG4999	Histidine kinase
K6V19_RS02715	COG3850	Histidine kinase
K6V19_RS02720	COG0745	RESPONSE REGULATOR receiver
K6V19_RS02765	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6V19_RS02770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6V19_RS02790	COG4974	Belongs to the 'phage' integrase family
K6V19_RS02805	COG0606	chelatase, subunit chli
K6V19_RS02850	COG1216	Glycosyl transferase, family 2
K6V19_RS02875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6V19_RS02880	COG0438	transferase activity, transferring glycosyl groups
K6V19_RS02890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6V19_RS02895	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V19_RS02900	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V19_RS02920	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K6V19_RS02940	COG0745	RESPONSE REGULATOR receiver
K6V19_RS02940	COG2205	protein histidine kinase activity
K6V19_RS02940	COG3292	Two component regulator propeller
K6V19_RS02960	COG4771	TonB-dependent receptor
K6V19_RS02970	COG4771	TonB-dependent receptor
K6V19_RS02975	COG0702	epimerase
K6V19_RS03005	COG3250	beta-galactosidase activity
K6V19_RS03015	COG1940	carbohydrate kinase activity
K6V19_RS03035	COG1629	transport
K6V19_RS03035	COG4206	TonB-dependent receptor
K6V19_RS03060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6V19_RS03060	COG1328	CTP reductase activity
K6V19_RS03080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6V19_RS03085	COG0793	Belongs to the peptidase S41A family
K6V19_RS03085	COG3409	Peptidoglycan-binding domain 1 protein
K6V19_RS03105	COG1053	succinate dehydrogenase
K6V19_RS03110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6V19_RS03140	COG0826	peptidase U32
K6V19_RS03145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6V19_RS03165	COG0557	exoribonuclease II activity
K6V19_RS03175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6V19_RS03185	COG0738	Major facilitator superfamily
K6V19_RS03195	COG2814	Major facilitator Superfamily
K6V19_RS03200	COG0012	GTP binding
K6V19_RS03205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6V19_RS03210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6V19_RS03220	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS03225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V19_RS03240	COG4452	Inner membrane protein CreD
K6V19_RS03255	COG0495	leucyl-tRNA aminoacylation
K6V19_RS03260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6V19_RS03265	COG3328	transposase activity
K6V19_RS03290	COG2755	lipolytic protein G-D-S-L family
K6V19_RS03290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6V19_RS03305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6V19_RS03325	COG0731	radical SAM domain protein
K6V19_RS03325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V19_RS03330	COG0659	secondary active sulfate transmembrane transporter activity
K6V19_RS03335	COG1592	Rubrerythrin
K6V19_RS03340	COG2205	protein histidine kinase activity
K6V19_RS03340	COG3292	Two component regulator propeller
K6V19_RS03340	COG0745	RESPONSE REGULATOR receiver
K6V19_RS03345	COG0702	epimerase
K6V19_RS03350	COG1629	transport
K6V19_RS03360	COG4771	TonB-dependent receptor
K6V19_RS03385	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V19_RS03400	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V19_RS03405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6V19_RS03445	COG0702	epimerase
K6V19_RS03450	COG1629	transport
K6V19_RS03455	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS03500	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS03520	COG0702	epimerase
K6V19_RS03525	COG4771	TonB-dependent receptor
K6V19_RS03545	COG2814	Major facilitator Superfamily
K6V19_RS03555	COG0427	acetyl-CoA hydrolase
K6V19_RS03565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V19_RS03575	COG3458	cephalosporin-C deacetylase activity
K6V19_RS03580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V19_RS03585	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K6V19_RS03600	COG2271	Major facilitator Superfamily
K6V19_RS03615	COG0702	epimerase
K6V19_RS03620	COG4771	TonB-dependent receptor
K6V19_RS03640	COG2177	Part of the ABC transporter FtsEX involved in
K6V19_RS03650	COG1968	undecaprenyl-diphosphatase activity
K6V19_RS03655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6V19_RS03660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V19_RS03665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6V19_RS03710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6V19_RS03715	COG1611	Belongs to the LOG family
K6V19_RS03730	COG0594	ribonuclease P activity
K6V19_RS03735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K6V19_RS03740	COG0084	hydrolase, TatD family'
K6V19_RS03745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6V19_RS03765	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K6V19_RS03770	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS03785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6V19_RS03790	COG0726	polysaccharide deacetylase
K6V19_RS03800	COG1121	(ABC) transporter
K6V19_RS03815	COG1238	metal cluster binding
K6V19_RS03830	COG0823	Involved in the tonB-independent uptake of proteins
K6V19_RS03830	COG1506	peptidase
K6V19_RS03840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6V19_RS03840	COG0116	Belongs to the methyltransferase superfamily
K6V19_RS03845	COG1045	serine acetyltransferase
K6V19_RS03865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V19_RS03865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V19_RS03870	COG0142	geranyltranstransferase activity
K6V19_RS03880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6V19_RS03885	COG1694	Mazg nucleotide pyrophosphohydrolase
K6V19_RS03895	COG0322	excinuclease ABC activity
K6V19_RS03900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V19_RS03915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6V19_RS03920	COG2715	membrane protein required for spore maturation
K6V19_RS03960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6V19_RS03965	COG0805	protein transport
K6V19_RS03975	COG2255	four-way junction helicase activity
K6V19_RS03990	COG3591	Belongs to the peptidase S1B family
K6V19_RS04025	COG0612	Peptidase, M16
K6V19_RS04030	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS04035	COG3401	FG-GAP repeat protein
K6V19_RS04050	COG0681	Belongs to the peptidase S26 family
K6V19_RS04060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6V19_RS04110	COG5492	domain, Protein
K6V19_RS04115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6V19_RS04120	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6V19_RS04130	COG4771	TonB-dependent receptor
K6V19_RS04135	COG0702	epimerase
K6V19_RS04140	COG5492	domain, Protein
K6V19_RS04170	COG3119	arylsulfatase activity
K6V19_RS04175	COG0745	RESPONSE REGULATOR receiver
K6V19_RS04175	COG2205	protein histidine kinase activity
K6V19_RS04175	COG3292	Two component regulator propeller
K6V19_RS04190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V19_RS04195	COG1538	Outer membrane efflux protein
K6V19_RS04225	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V19_RS04230	COG3119	arylsulfatase activity
K6V19_RS04235	COG0215	cysteine-tRNA ligase activity
K6V19_RS04240	COG0561	phosphatase activity
K6V19_RS04255	COG0482	sulfurtransferase activity
K6V19_RS04270	COG0205	6-phosphofructokinase activity
K6V19_RS04275	COG0571	ribonuclease III activity
K6V19_RS04280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6V19_RS04285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6V19_RS04290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6V19_RS04300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6V19_RS04310	COG0859	PFAM glycosyl transferase family 9
K6V19_RS04330	COG0463	Glycosyl transferase, family 2
K6V19_RS04355	COG1215	transferase activity, transferring glycosyl groups
K6V19_RS04360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6V19_RS04370	COG3475	LICD family
K6V19_RS04375	COG1216	Glycosyl transferase, family 2
K6V19_RS04395	COG1215	transferase activity, transferring glycosyl groups
K6V19_RS04400	COG1132	(ABC) transporter
K6V19_RS04410	COG0328	RNA-DNA hybrid ribonuclease activity
K6V19_RS04410	COG3341	Caulimovirus viroplasmin
K6V19_RS04420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6V19_RS04425	COG1166	arginine decarboxylase activity
K6V19_RS04430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6V19_RS04470	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS04485	COG1454	alcohol dehydrogenase
K6V19_RS04495	COG1070	Carbohydrate kinase
K6V19_RS04505	COG0738	Major facilitator superfamily
K6V19_RS04520	COG4771	TonB-dependent receptor
K6V19_RS04545	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS04550	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS04610	COG0745	RESPONSE REGULATOR receiver
K6V19_RS04610	COG2205	protein histidine kinase activity
K6V19_RS04610	COG3292	Two component regulator propeller
K6V19_RS04660	COG3250	beta-galactosidase activity
K6V19_RS04665	COG0779	Required for maturation of 30S ribosomal subunits
K6V19_RS04670	COG0195	Participates in both transcription termination and antitermination
K6V19_RS04675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6V19_RS04685	COG0719	Fe-S assembly protein
K6V19_RS04690	COG0396	ATPase activity
K6V19_RS04695	COG0719	Fe-S assembly protein
K6V19_RS04700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6V19_RS04710	COG0393	Putative heavy-metal-binding
K6V19_RS04720	COG2217	Heavy metal translocating P-type atpase
K6V19_RS04725	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K6V19_RS04735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6V19_RS04755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6V19_RS04770	COG3594	Acyltransferase
K6V19_RS04780	COG0187	DNA topoisomerase II activity
K6V19_RS04785	COG0268	Binds directly to 16S ribosomal RNA
K6V19_RS04795	COG1381	Involved in DNA repair and RecF pathway recombination
K6V19_RS04800	COG1610	YqeY-like protein
K6V19_RS04805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6V19_RS04810	COG0849	cell division
K6V19_RS04820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6V19_RS04825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6V19_RS04830	COG0772	Belongs to the SEDS family
K6V19_RS04835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6V19_RS04840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V19_RS04845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6V19_RS04850	COG0768	penicillin binding
K6V19_RS04860	COG0275	rRNA processing
K6V19_RS04950	COG1629	transport
K6V19_RS04950	COG4206	TonB-dependent receptor
K6V19_RS04975	COG0657	acetylesterase activity
K6V19_RS04975	COG2755	lipolytic protein G-D-S-L family
K6V19_RS04980	COG0657	acetylesterase activity
K6V19_RS04980	COG2755	lipolytic protein G-D-S-L family
K6V19_RS04995	COG2376	Dihydroxyacetone kinase
K6V19_RS05000	COG2376	Dihydroxyacetone kinase
K6V19_RS05010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V19_RS05010	COG1333	cytochrome c biogenesis protein
K6V19_RS05035	COG1414	Transcriptional regulator
K6V19_RS05040	COG1595	DNA-templated transcription, initiation
K6V19_RS05060	COG0756	dUTP diphosphatase activity
K6V19_RS05075	COG4942	peptidase
K6V19_RS05085	COG3250	beta-galactosidase activity
K6V19_RS05110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6V19_RS05115	COG1022	Amp-dependent synthetase and ligase
K6V19_RS05120	COG0612	Peptidase, M16
K6V19_RS05130	COG2207	Transcriptional regulator
K6V19_RS05130	COG0662	Cupin 2, conserved barrel domain protein
K6V19_RS05145	COG2954	triphosphatase activity
K6V19_RS05200	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS05205	COG0702	epimerase
K6V19_RS05210	COG4771	TonB-dependent receptor
K6V19_RS05250	COG0423	glycine-tRNA ligase activity
K6V19_RS05260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6V19_RS05265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6V19_RS05285	COG3876	Protein conserved in bacteria
K6V19_RS05305	COG1215	transferase activity, transferring glycosyl groups
K6V19_RS05310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6V19_RS05315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6V19_RS05320	COG3876	Protein conserved in bacteria
K6V19_RS05340	COG1629	transport
K6V19_RS05360	COG1649	PFAM Uncharacterised BCR, COG1649
K6V19_RS05400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6V19_RS05405	COG0475	glutathione-regulated potassium exporter activity
K6V19_RS05405	COG0589	response to stress
K6V19_RS05410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6V19_RS05415	COG1136	(ABC) transporter
K6V19_RS05425	COG0733	neurotransmitter:sodium symporter activity
K6V19_RS05435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6V19_RS05440	COG4974	Belongs to the 'phage' integrase family
K6V19_RS05475	COG2205	protein histidine kinase activity
K6V19_RS05480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6V19_RS05485	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K6V19_RS05490	COG0312	modulator of DNA gyrase
K6V19_RS05495	COG0312	modulator of DNA gyrase
K6V19_RS05510	COG1346	cytolysis
K6V19_RS05515	COG1380	Effector of murein hydrolase LrgA
K6V19_RS05535	COG0280	phosphate acetyltransferase
K6V19_RS05540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6V19_RS05545	COG1216	Glycosyl transferase, family 2
K6V19_RS05545	COG0463	Glycosyl transferase, family 2
K6V19_RS05550	COG2003	Belongs to the UPF0758 family
K6V19_RS05585	COG1785	Belongs to the alkaline phosphatase family
K6V19_RS05590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6V19_RS05595	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K6V19_RS05605	COG0564	pseudouridine synthase activity
K6V19_RS05630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K6V19_RS05635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6V19_RS05640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6V19_RS05645	COG0436	Aminotransferase
K6V19_RS05655	COG2198	Histidine kinase
K6V19_RS05655	COG0784	Response regulator, receiver
K6V19_RS05655	COG5002	protein histidine kinase activity
K6V19_RS05665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6V19_RS05680	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6V19_RS05685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6V19_RS05700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V19_RS05700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V19_RS05705	COG2890	protein-(glutamine-N5) methyltransferase activity
K6V19_RS05715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6V19_RS05745	COG1629	transport
K6V19_RS05745	COG4206	TonB-dependent receptor
K6V19_RS05785	COG1629	transport
K6V19_RS05805	COG1649	PFAM Uncharacterised BCR, COG1649
K6V19_RS05815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6V19_RS05820	COG1396	sequence-specific DNA binding
K6V19_RS05820	COG1917	Cupin 2, conserved barrel domain protein
K6V19_RS05825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6V19_RS05830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6V19_RS05840	COG0137	argininosuccinate synthase activity
K6V19_RS05925	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V19_RS05935	COG3401	FG-GAP repeat protein
K6V19_RS05945	COG1070	Carbohydrate kinase
K6V19_RS05950	COG4806	L-rhamnose isomerase
K6V19_RS05960	COG0235	Class ii aldolase
K6V19_RS06005	COG4771	TonB-dependent receptor
K6V19_RS06010	COG0702	epimerase
K6V19_RS06025	COG4771	TonB-dependent receptor
K6V19_RS06035	COG3401	FG-GAP repeat protein
K6V19_RS06040	COG3250	beta-galactosidase activity
K6V19_RS06065	COG2755	lipolytic protein G-D-S-L family
K6V19_RS06080	COG0531	amino acid
K6V19_RS06095	COG0076	glutamate decarboxylase activity
K6V19_RS06110	COG0534	Mate efflux family protein
K6V19_RS06115	COG0039	L-malate dehydrogenase activity
K6V19_RS06120	COG2996	Protein conserved in bacteria
K6V19_RS06195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V19_RS06205	COG0577	efflux transmembrane transporter activity
K6V19_RS06205	COG1136	(ABC) transporter
K6V19_RS06210	COG1136	(ABC) transporter
K6V19_RS06215	COG1940	carbohydrate kinase activity
K6V19_RS06235	COG0335	large ribosomal subunit rRNA binding
K6V19_RS06240	COG0737	Belongs to the 5'-nucleotidase family
K6V19_RS06245	COG0737	Belongs to the 5'-nucleotidase family
K6V19_RS06250	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS06275	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6V19_RS06285	COG2204	response regulator
K6V19_RS06295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K6V19_RS06305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K6V19_RS06315	COG2205	protein histidine kinase activity
K6V19_RS06365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6V19_RS06365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6V19_RS06395	COG0826	peptidase U32
K6V19_RS06405	COG4771	TonB-dependent receptor
K6V19_RS06410	COG0671	phosphoesterase, PA-phosphatase related
K6V19_RS06420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K6V19_RS06425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6V19_RS06430	COG0252	asparaginase activity
K6V19_RS06435	COG0527	aspartate kinase activity
K6V19_RS06435	COG0460	homoserine dehydrogenase
K6V19_RS06440	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
K6V19_RS06445	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6V19_RS06465	COG0668	transmembrane transport
K6V19_RS06475	COG0534	Mate efflux family protein
K6V19_RS06490	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS06510	COG0628	permease
K6V19_RS06515	COG1435	thymidine kinase activity
K6V19_RS06525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6V19_RS06540	COG2095	MarC family integral membrane protein
K6V19_RS06560	COG4206	TonB-dependent receptor
K6V19_RS06560	COG1629	transport
K6V19_RS06590	COG4771	TonB-dependent receptor
K6V19_RS06595	COG4974	Belongs to the 'phage' integrase family
K6V19_RS06600	COG4771	TonB-dependent receptor
K6V19_RS06620	COG4771	TonB-dependent receptor
K6V19_RS06635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6V19_RS06645	COG2205	protein histidine kinase activity
K6V19_RS06645	COG0745	RESPONSE REGULATOR receiver
K6V19_RS06645	COG3292	Two component regulator propeller
K6V19_RS06645	COG2205	protein histidine kinase activity
K6V19_RS06645	COG0745	RESPONSE REGULATOR receiver
K6V19_RS06645	COG3292	Two component regulator propeller
K6V19_RS06660	COG4771	TonB-dependent receptor
K6V19_RS06680	COG3250	beta-galactosidase activity
K6V19_RS06690	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V19_RS06690	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V19_RS06760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6V19_RS06765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V19_RS06770	COG1162	GTPase activity
K6V19_RS06775	COG0233	cytoplasmic translational termination
K6V19_RS06780	COG0528	UMP kinase activity
K6V19_RS06790	COG0534	Mate efflux family protein
K6V19_RS06810	COG0792	nuclease activity
K6V19_RS06830	COG1183	phosphatidylcholine synthase activity
K6V19_RS06835	COG0688	phosphatidylethanolamine metabolic process
K6V19_RS06880	COG0714	Associated with various cellular activities
K6V19_RS06895	COG0802	atpase or kinase
K6V19_RS06900	COG0745	RESPONSE REGULATOR receiver
K6V19_RS06910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6V19_RS06920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K6V19_RS06930	COG4771	TonB-dependent receptor
K6V19_RS06950	COG2198	Histidine kinase
K6V19_RS06950	COG0784	Response regulator, receiver
K6V19_RS06950	COG2205	protein histidine kinase activity
K6V19_RS06955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6V19_RS06970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6V19_RS06975	COG0742	ribosomal rna small subunit methyltransferase
K6V19_RS06995	COG1082	Xylose isomerase domain protein TIM barrel
K6V19_RS07010	COG4771	TonB-dependent receptor
K6V19_RS07015	COG3537	Alpha-1,2-mannosidase
K6V19_RS07040	COG0739	heme binding
K6V19_RS07050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V19_RS07065	COG1475	DNA binding
K6V19_RS07070	COG1192	Involved in chromosome partitioning
K6V19_RS07075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6V19_RS07080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V19_RS07090	COG4589	Belongs to the CDS family
K6V19_RS07095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6V19_RS07100	COG0799	negative regulation of ribosome biogenesis
K6V19_RS07115	COG2239	Acts as a magnesium transporter
K6V19_RS07120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6V19_RS07130	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V19_RS07150	COG3279	Response regulator of the LytR AlgR family
K6V19_RS07155	COG3275	phosphorelay sensor kinase activity
K6V19_RS07215	COG0668	transmembrane transport
K6V19_RS07220	COG2207	Transcriptional regulator
K6V19_RS07220	COG0662	Cupin 2, conserved barrel domain protein
K6V19_RS07225	COG0667	Aldo Keto reductase
K6V19_RS07235	COG2211	Major facilitator Superfamily
K6V19_RS07240	COG2942	2-epimerase
K6V19_RS07265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V19_RS07270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6V19_RS07275	COG0713	ATP synthesis coupled electron transport
K6V19_RS07280	COG0839	Belongs to the complex I subunit 6 family
K6V19_RS07290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K6V19_RS07295	COG0649	NAD binding
K6V19_RS07295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V19_RS07300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V19_RS07305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V19_RS07315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V19_RS07320	COG0569	domain protein
K6V19_RS07325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6V19_RS07335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6V19_RS07340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6V19_RS07345	COG0805	protein transport
K6V19_RS07355	COG1917	Cupin 2, conserved barrel domain protein
K6V19_RS07355	COG4977	sequence-specific DNA binding
K6V19_RS07365	COG2271	Major facilitator Superfamily
K6V19_RS07370	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V19_RS07380	COG1917	Cupin 2, conserved barrel domain protein
K6V19_RS07385	COG2755	lipolytic protein G-D-S-L family
K6V19_RS07390	COG1073	alpha beta
K6V19_RS07395	COG3292	Two component regulator propeller
K6V19_RS07395	COG2205	protein histidine kinase activity
K6V19_RS07395	COG0745	RESPONSE REGULATOR receiver
K6V19_RS07410	COG3250	beta-galactosidase activity
K6V19_RS07415	COG3250	beta-galactosidase activity
K6V19_RS07440	COG3250	beta-galactosidase activity
K6V19_RS07445	COG3292	Two component regulator propeller
K6V19_RS07445	COG2205	protein histidine kinase activity
K6V19_RS07445	COG0745	RESPONSE REGULATOR receiver
K6V19_RS07470	COG4206	TonB-dependent receptor
K6V19_RS07470	COG1629	transport
K6V19_RS07475	COG0702	epimerase
K6V19_RS07480	COG4677	pectinesterase activity
K6V19_RS07525	COG3408	Glycogen debranching enzyme
K6V19_RS07575	COG1501	Belongs to the glycosyl hydrolase 31 family
K6V19_RS07580	COG5012	cobalamin binding
K6V19_RS07595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6V19_RS07605	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V19_RS07615	COG3408	Glycogen debranching enzyme
K6V19_RS07645	COG1063	alcohol dehydrogenase
K6V19_RS07650	COG4771	TonB-dependent receptor
K6V19_RS07670	COG4677	pectinesterase activity
K6V19_RS07725	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS07730	COG3292	Two component regulator propeller
K6V19_RS07730	COG0745	RESPONSE REGULATOR receiver
K6V19_RS07730	COG2205	protein histidine kinase activity
K6V19_RS07745	COG0326	Molecular chaperone. Has ATPase activity
K6V19_RS07765	COG4206	TonB-dependent receptor
K6V19_RS07765	COG1629	transport
K6V19_RS07770	COG3458	cephalosporin-C deacetylase activity
K6V19_RS07775	COG2755	lipolytic protein G-D-S-L family
K6V19_RS07775	COG0657	acetylesterase activity
K6V19_RS07780	COG0546	phosphoglycolate phosphatase activity
K6V19_RS07805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6V19_RS07825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6V19_RS07840	COG3279	Response regulator of the LytR AlgR family
K6V19_RS07845	COG1242	4 iron, 4 sulfur cluster binding
K6V19_RS07855	COG0363	glucosamine-6-phosphate deaminase activity
K6V19_RS07860	COG0009	L-threonylcarbamoyladenylate synthase
K6V19_RS07870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V19_RS07875	COG0561	phosphatase activity
K6V19_RS07880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6V19_RS07885	COG2873	o-acetylhomoserine
K6V19_RS07890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V19_RS07890	COG2198	Histidine kinase
K6V19_RS07890	COG0784	Response regulator, receiver
K6V19_RS07890	COG2205	protein histidine kinase activity
K6V19_RS07895	COG1073	alpha beta
K6V19_RS07910	COG1629	transport
K6V19_RS07910	COG4206	TonB-dependent receptor
K6V19_RS07915	COG4585	Histidine kinase
K6V19_RS07920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6V19_RS07930	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V19_RS07935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6V19_RS07935	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6V19_RS07940	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V19_RS07945	COG1078	dGTPase activity
K6V19_RS07955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6V19_RS07960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6V19_RS07965	COG1704	LemA family
K6V19_RS07980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6V19_RS07985	COG2226	methyltransferase
K6V19_RS07990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6V19_RS07995	COG1702	phosphate starvation-inducible protein PhoH
K6V19_RS08005	COG2268	Band 7 protein
K6V19_RS08025	COG0101	tRNA pseudouridine synthase activity
K6V19_RS08045	COG3250	beta-galactosidase activity
K6V19_RS08070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K6V19_RS08080	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS08105	COG4206	TonB-dependent receptor
K6V19_RS08105	COG1629	transport
K6V19_RS08130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6V19_RS08135	COG0793	Belongs to the peptidase S41A family
K6V19_RS08140	COG2131	deaminase
K6V19_RS08150	COG0339	signal peptide processing
K6V19_RS08160	COG1970	mechanosensitive ion channel activity
K6V19_RS08170	COG0519	Catalyzes the synthesis of GMP from XMP
K6V19_RS08170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6V19_RS08200	COG3537	Alpha-1,2-mannosidase
K6V19_RS08215	COG1629	transport
K6V19_RS08215	COG4206	TonB-dependent receptor
K6V19_RS08245	COG3408	Glycogen debranching enzyme
K6V19_RS08250	COG3408	Glycogen debranching enzyme
K6V19_RS08275	COG4771	TonB-dependent receptor
K6V19_RS08280	COG0561	phosphatase activity
K6V19_RS08290	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS08305	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS08320	COG2755	lipolytic protein G-D-S-L family
K6V19_RS08330	COG2205	protein histidine kinase activity
K6V19_RS08330	COG3292	Two component regulator propeller
K6V19_RS08330	COG2205	protein histidine kinase activity
K6V19_RS08330	COG0745	RESPONSE REGULATOR receiver
K6V19_RS08330	COG0745	RESPONSE REGULATOR receiver
K6V19_RS08330	COG3292	Two component regulator propeller
K6V19_RS08360	COG0297	glycogen (starch) synthase activity
K6V19_RS08365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6V19_RS08370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K6V19_RS08375	COG0543	2 iron, 2 sulfur cluster binding
K6V19_RS08380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6V19_RS08385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6V19_RS08390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6V19_RS08395	COG0546	phosphoglycolate phosphatase activity
K6V19_RS08405	COG0791	NLP P60 protein
K6V19_RS08420	COG0612	Peptidase, M16
K6V19_RS08425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6V19_RS08430	COG1597	lipid kinase activity
K6V19_RS08435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6V19_RS08445	COG1136	(ABC) transporter
K6V19_RS08465	COG2211	Major facilitator Superfamily
K6V19_RS08470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6V19_RS08485	COG1674	ftsk spoiiie
K6V19_RS08495	COG0492	ferredoxin-NADP+ reductase activity
K6V19_RS08500	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS08530	COG1629	transport
K6V19_RS08530	COG4206	TonB-dependent receptor
K6V19_RS08560	COG1234	tRNA 3'-trailer cleavage
K6V19_RS08570	COG2989	Protein conserved in bacteria
K6V19_RS08575	COG1595	DNA-templated transcription, initiation
K6V19_RS08590	COG3956	TIGRFAM MazG family protein
K6V19_RS08610	COG0525	valine-tRNA ligase activity
K6V19_RS08630	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
K6V19_RS08645	COG2226	methyltransferase
K6V19_RS08650	COG0784	Response regulator, receiver
K6V19_RS08650	COG2205	protein histidine kinase activity
K6V19_RS08685	COG1086	Polysaccharide biosynthesis protein
K6V19_RS08690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V19_RS08695	COG1083	cytidylyl-transferase
K6V19_RS08705	COG2089	acid synthase
K6V19_RS08710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6V19_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS08720	COG3959	Transketolase, thiamine diphosphate binding domain
K6V19_RS08725	COG3958	Transketolase
K6V19_RS08755	COG0438	transferase activity, transferring glycosyl groups
K6V19_RS08760	COG0318	PFAM AMP-dependent synthetase and ligase
K6V19_RS08780	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS08800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V19_RS08805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6V19_RS08810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6V19_RS08830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K6V19_RS08850	COG1253	flavin adenine dinucleotide binding
K6V19_RS08855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6V19_RS08870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6V19_RS08915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6V19_RS08915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6V19_RS08925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6V19_RS08930	COG0563	adenylate kinase activity
K6V19_RS08940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V19_RS08945	COG1496	oxidoreductase activity
K6V19_RS08965	COG2706	6-phosphogluconolactonase activity
K6V19_RS08970	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS08980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6V19_RS09000	COG0745	RESPONSE REGULATOR receiver
K6V19_RS09000	COG3292	Two component regulator propeller
K6V19_RS09000	COG2205	protein histidine kinase activity
K6V19_RS09035	COG1288	antiporter activity
K6V19_RS09045	COG3142	Participates in the control of copper homeostasis
K6V19_RS09050	COG1418	mRNA catabolic process
K6V19_RS09090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V19_RS09095	COG2832	Protein of unknown function (DUF454)
K6V19_RS09105	COG0602	queuosine metabolic process
K6V19_RS09110	COG0247	lactate metabolic process
K6V19_RS09115	COG1139	Iron-sulfur cluster binding protein
K6V19_RS09125	COG0351	phosphomethylpyrimidine kinase
K6V19_RS09130	COG2304	oxidoreductase activity
K6V19_RS09135	COG4771	TonB-dependent receptor
K6V19_RS09145	COG4948	Mandelate Racemase Muconate Lactonizing
K6V19_RS09160	COG4771	TonB-dependent receptor
K6V19_RS09170	COG1393	Belongs to the ArsC family
K6V19_RS09180	COG4771	TonB-dependent receptor
K6V19_RS09190	COG1509	lysine 2,3-aminomutase activity
K6V19_RS09240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6V19_RS09245	COG0741	lytic transglycosylase activity
K6V19_RS09245	COG1388	LysM domain
K6V19_RS09255	COG1090	epimerase
K6V19_RS09275	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V19_RS09290	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K6V19_RS09295	COG0564	pseudouridine synthase activity
K6V19_RS09330	COG0693	protein deglycase activity
K6V19_RS09335	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
K6V19_RS09340	COG3387	PFAM Glycoside hydrolase 15-related
K6V19_RS09350	COG3275	phosphorelay sensor kinase activity
K6V19_RS09355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V19_RS09365	COG1538	Outer membrane efflux protein
K6V19_RS09395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6V19_RS09410	COG3645	SOS response
K6V19_RS09435	COG0582	viral genome integration into host DNA
K6V19_RS09470	COG4974	Belongs to the 'phage' integrase family
K6V19_RS09490	COG3550	peptidyl-serine autophosphorylation
K6V19_RS09545	COG0732	type I restriction modification DNA specificity domain
K6V19_RS09550	COG4974	Belongs to the 'phage' integrase family
K6V19_RS09590	COG1910	domain protein
K6V19_RS09610	COG4974	Belongs to the 'phage' integrase family
K6V19_RS09620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6V19_RS09625	COG0784	Response regulator, receiver
K6V19_RS09625	COG2205	protein histidine kinase activity
K6V19_RS09645	COG4864	UPF0365 protein
K6V19_RS09660	COG0037	tRNA processing
K6V19_RS09670	COG1477	protein flavinylation
K6V19_RS09675	COG1971	Probably functions as a manganese efflux pump
K6V19_RS09690	COG0463	Glycosyl transferase, family 2
K6V19_RS09710	COG0148	phosphopyruvate hydratase activity
K6V19_RS09720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6V19_RS09730	COG1082	Xylose isomerase domain protein TIM barrel
K6V19_RS09735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6V19_RS09740	COG3328	transposase activity
K6V19_RS09745	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K6V19_RS09755	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V19_RS09760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6V19_RS09765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6V19_RS09765	COG4651	solute:proton antiporter activity
K6V19_RS09775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6V19_RS09780	COG0193	aminoacyl-tRNA hydrolase activity
K6V19_RS09785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6V19_RS09795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6V19_RS09800	COG1862	Preprotein translocase
K6V19_RS09810	COG0237	dephospho-CoA kinase activity
K6V19_RS09825	COG3328	transposase activity
K6V19_RS09830	COG0542	response to heat
K6V19_RS09840	COG0583	DNA-binding transcription factor activity
K6V19_RS09845	COG2855	membrane
K6V19_RS09860	COG1595	DNA-templated transcription, initiation
K6V19_RS09870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6V19_RS09895	COG0443	Heat shock 70 kDa protein
K6V19_RS09905	COG4974	Belongs to the 'phage' integrase family
K6V19_RS09940	COG4974	Belongs to the 'phage' integrase family
K6V19_RS09945	COG0732	type I restriction modification DNA specificity domain
K6V19_RS10080	COG0514	ATP-dependent DNA helicase (RecQ)
K6V19_RS10125	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6V19_RS10135	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K6V19_RS10140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V19_RS10170	COG1082	Xylose isomerase domain protein TIM barrel
K6V19_RS10285	COG0745	RESPONSE REGULATOR receiver
K6V19_RS10285	COG3292	Two component regulator propeller
K6V19_RS10285	COG2205	protein histidine kinase activity
K6V19_RS10290	COG4206	TonB-dependent receptor
K6V19_RS10290	COG1629	transport
K6V19_RS10330	COG1760	l-serine dehydratase
K6V19_RS10335	COG0598	Magnesium transport protein CorA
K6V19_RS10340	COG1193	negative regulation of DNA recombination
K6V19_RS10395	COG4804	nuclease activity
K6V19_RS10405	COG1063	alcohol dehydrogenase
K6V19_RS10415	COG2755	lipolytic protein G-D-S-L family
K6V19_RS10415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6V19_RS10450	COG0702	epimerase
K6V19_RS10495	COG3537	Alpha-1,2-mannosidase
K6V19_RS10500	COG0561	phosphatase activity
K6V19_RS10505	COG1169	isochorismate synthase
K6V19_RS10510	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6V19_RS10515	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6V19_RS10520	COG4948	Mandelate Racemase Muconate Lactonizing
K6V19_RS10540	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS10545	COG3250	beta-galactosidase activity
K6V19_RS10560	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V19_RS10565	COG3537	Alpha-1,2-mannosidase
K6V19_RS10570	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS10575	COG0783	Belongs to the Dps family
K6V19_RS10605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6V19_RS10665	COG4804	nuclease activity
K6V19_RS10675	COG2205	protein histidine kinase activity
K6V19_RS10675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V19_RS10675	COG0784	Response regulator, receiver
K6V19_RS10675	COG2198	Histidine kinase
K6V19_RS10695	COG2610	gluconate transmembrane transporter activity
K6V19_RS10700	COG1929	Belongs to the glycerate kinase type-1 family
K6V19_RS10730	COG4206	TonB-dependent receptor
K6V19_RS10730	COG1629	transport
K6V19_RS10750	COG1253	flavin adenine dinucleotide binding
K6V19_RS10780	COG0482	sulfurtransferase activity
K6V19_RS10785	COG2197	response regulator
K6V19_RS10810	COG2814	Major facilitator Superfamily
K6V19_RS10815	COG4953	penicillin-binding protein 1C
K6V19_RS10820	COG2373	Large extracellular alpha-helical protein
K6V19_RS10880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6V19_RS10885	COG0646	methionine synthase
K6V19_RS10885	COG1410	methionine synthase
K6V19_RS10910	COG0572	uridine kinase
K6V19_RS10920	COG4232	protein-disulfide reductase activity
K6V19_RS10925	COG1741	Belongs to the pirin family
K6V19_RS10945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6V19_RS10950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6V19_RS10955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6V19_RS10960	COG0131	Imidazoleglycerol-phosphate dehydratase
K6V19_RS10965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V19_RS10965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6V19_RS10970	COG0735	belongs to the Fur family
K6V19_RS10975	COG1773	rubredoxin
K6V19_RS10975	COG1592	Rubrerythrin
K6V19_RS11010	COG3118	belongs to the thioredoxin family
K6V19_RS11030	COG3591	Belongs to the peptidase S1B family
K6V19_RS11035	COG3591	Belongs to the peptidase S1B family
K6V19_RS11040	COG0641	radical SAM
K6V19_RS11070	COG5002	protein histidine kinase activity
K6V19_RS11075	COG2205	protein histidine kinase activity
K6V19_RS11080	COG0420	3'-5' exonuclease activity
K6V19_RS11115	COG5492	domain, Protein
K6V19_RS11130	COG0646	methionine synthase
K6V19_RS11130	COG1410	methionine synthase
K6V19_RS11135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6V19_RS11140	COG0463	Glycosyl transferase, family 2
K6V19_RS11145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6V19_RS11150	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6V19_RS11180	COG2264	protein methyltransferase activity
K6V19_RS11195	COG0590	tRNA wobble adenosine to inosine editing
K6V19_RS11215	COG1595	DNA-templated transcription, initiation
K6V19_RS11225	COG0673	inositol 2-dehydrogenase activity
K6V19_RS11230	COG3940	Belongs to the glycosyl hydrolase 43 family
K6V19_RS11235	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6V19_RS11285	COG0698	ribose 5-phosphate isomerase
K6V19_RS11290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6V19_RS11300	COG2160	L-arabinose isomerase activity
K6V19_RS11325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6V19_RS11340	COG1482	cell wall glycoprotein biosynthetic process
K6V19_RS11355	COG4585	Histidine kinase
K6V19_RS11380	COG0513	Belongs to the DEAD box helicase family
K6V19_RS11385	COG4221	oxidoreductase activity
K6V19_RS11400	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6V19_RS11405	COG0471	metal ion transport
K6V19_RS11405	COG3273	potassium ion transport
K6V19_RS11415	COG0529	Catalyzes the synthesis of activated sulfate
K6V19_RS11420	COG0175	sulfate reduction
K6V19_RS11440	COG3328	transposase activity
K6V19_RS11465	COG4974	Belongs to the 'phage' integrase family
K6V19_RS11490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6V19_RS11495	COG0242	peptide deformylase activity
K6V19_RS11510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6V19_RS11515	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K6V19_RS11520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6V19_RS11525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K6V19_RS11535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V19_RS11540	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V19_RS11545	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6V19_RS11545	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6V19_RS11545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6V19_RS11545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K6V19_RS11555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6V19_RS11580	COG1940	carbohydrate kinase activity
K6V19_RS11585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6V19_RS11595	COG2271	Major facilitator Superfamily
K6V19_RS11605	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS11615	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
K6V19_RS11630	COG4771	TonB-dependent receptor
K6V19_RS11635	COG0702	epimerase
K6V19_RS11710	COG4413	Urea transporter
K6V19_RS11715	COG0484	heat shock protein binding
K6V19_RS11720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6V19_RS11725	COG0488	(ABC) transporter
K6V19_RS11740	COG1595	DNA-templated transcription, initiation
K6V19_RS11765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V19_RS11770	COG2205	protein histidine kinase activity
K6V19_RS11770	COG0745	RESPONSE REGULATOR receiver
K6V19_RS11770	COG3292	Two component regulator propeller
K6V19_RS11780	COG0252	asparaginase activity
K6V19_RS11785	COG0159	tryptophan synthase activity
K6V19_RS11790	COG0135	phosphoribosylanthranilate isomerase activity
K6V19_RS11795	COG0134	indole-3-glycerol-phosphate synthase activity
K6V19_RS11805	COG0512	Glutamine amidotransferase of anthranilate synthase
K6V19_RS11805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6V19_RS11810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6V19_RS11815	COG0133	tryptophan synthase activity
K6V19_RS11820	COG1979	alcohol dehydrogenase
K6V19_RS11830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6V19_RS11845	COG0004	ammonium transporteR
K6V19_RS11850	COG0347	Belongs to the P(II) protein family
K6V19_RS11880	COG0367	asparagine synthase
K6V19_RS11890	COG0070	glutamate synthase
K6V19_RS11890	COG0069	glutamate synthase activity
K6V19_RS11890	COG0067	glutamate synthase
K6V19_RS11895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6V19_RS11905	COG0505	Belongs to the CarA family
K6V19_RS11930	COG0489	protein tyrosine kinase activity
K6V19_RS11930	COG3206	protein involved in exopolysaccharide biosynthesis
K6V19_RS11955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6V19_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS11985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6V19_RS12005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V19_RS12010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V19_RS12015	COG0784	Response regulator, receiver
K6V19_RS12015	COG5002	protein histidine kinase activity
K6V19_RS12020	COG5002	protein histidine kinase activity
K6V19_RS12030	COG2721	sulfolactate sulfo-lyase activity
K6V19_RS12035	COG1609	Transcriptional regulator
K6V19_RS12075	COG0490	domain, Protein
K6V19_RS12075	COG2985	domain, Protein
K6V19_RS12090	COG1132	(ABC) transporter
K6V19_RS12115	COG4771	TonB-dependent receptor
K6V19_RS12175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V19_RS12175	COG1333	cytochrome c biogenesis protein
K6V19_RS12175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6V19_RS12175	COG1333	cytochrome c biogenesis protein
K6V19_RS12180	COG0251	oxidation-reduction process
K6V19_RS12205	COG1730	sister chromatid segregation
K6V19_RS12215	COG0716	FMN binding
K6V19_RS12220	COG0138	bifunctional purine biosynthesis protein purh
K6V19_RS12230	COG2197	response regulator
K6V19_RS12245	COG2183	response to ionizing radiation
K6V19_RS12250	COG2205	protein histidine kinase activity
K6V19_RS12250	COG2202	Pas domain
K6V19_RS12255	COG0737	Belongs to the 5'-nucleotidase family
K6V19_RS12270	COG4771	TonB-dependent receptor
K6V19_RS12275	COG1917	Cupin 2, conserved barrel domain protein
K6V19_RS12275	COG4977	sequence-specific DNA binding
K6V19_RS12300	COG0534	Mate efflux family protein
K6V19_RS12310	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K6V19_RS12320	COG3119	arylsulfatase activity
K6V19_RS12330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V19_RS12335	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K6V19_RS12440	COG1216	Glycosyl transferase, family 2
K6V19_RS12440	COG1442	glycosyl transferase family 8
K6V19_RS12450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V19_RS12470	COG1301	dicarboxylic acid transport
K6V19_RS12475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6V19_RS12480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6V19_RS12510	COG4206	TonB-dependent receptor
K6V19_RS12510	COG1629	transport
K6V19_RS12615	COG0629	single-stranded DNA binding
K6V19_RS12650	COG1475	DNA binding
K6V19_RS12735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V19_RS12740	COG3728	DNA packaging
K6V19_RS12870	COG3279	Response regulator of the LytR AlgR family
K6V19_RS12880	COG0577	efflux transmembrane transporter activity
K6V19_RS12880	COG1136	(ABC) transporter
K6V19_RS12885	COG1136	(ABC) transporter
K6V19_RS12900	COG0534	Mate efflux family protein
K6V19_RS12910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6V19_RS12925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V19_RS12935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6V19_RS12940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6V19_RS12945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6V19_RS12955	COG0356	it plays a direct role in the translocation of protons across the membrane
K6V19_RS12960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V19_RS12965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6V19_RS12970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V19_RS12975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6V19_RS12980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6V19_RS12985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V19_RS13000	COG4206	TonB-dependent receptor
K6V19_RS13000	COG1629	transport
K6V19_RS13050	COG1074	ATP-dependent DNA helicase activity
K6V19_RS13060	COG4771	TonB-dependent receptor
K6V19_RS13075	COG1073	alpha beta
K6V19_RS13115	COG0501	Belongs to the peptidase M48B family
K6V19_RS13235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6V19_RS13285	COG0653	protein targeting
K6V19_RS13315	COG0318	PFAM AMP-dependent synthetase and ligase
K6V19_RS13325	COG3263	regulation of cellular component size
K6V19_RS13330	COG1151	hydroxylamine reductase activity
K6V19_RS13360	COG1136	(ABC) transporter
K6V19_RS13360	COG0577	efflux transmembrane transporter activity
K6V19_RS13385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V19_RS13395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6V19_RS13425	COG0612	Peptidase, M16
K6V19_RS13435	COG0501	Belongs to the peptidase M48B family
K6V19_RS13440	COG1704	LemA family
K6V19_RS13445	COG1595	DNA-templated transcription, initiation
K6V19_RS13460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6V19_RS13500	COG0488	(ABC) transporter
K6V19_RS13505	COG1629	transport
K6V19_RS13505	COG4206	TonB-dependent receptor
K6V19_RS13520	COG5002	protein histidine kinase activity
K6V19_RS13520	COG2198	Histidine kinase
K6V19_RS13520	COG0784	Response regulator, receiver
K6V19_RS13555	COG2244	polysaccharide biosynthetic process
K6V19_RS13610	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V19_RS13655	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V19_RS13660	COG1805	sodium ion transport
K6V19_RS13665	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V19_RS13680	COG2871	sodium ion transport
K6V19_RS13690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6V19_RS13695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6V19_RS13710	COG1739	Uncharacterized protein family UPF0029
K6V19_RS13730	COG0778	Nitroreductase
K6V19_RS13735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V19_RS13735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V19_RS13740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6V19_RS13745	COG0357	Ribosomal RNA small subunit methyltransferase G
K6V19_RS13770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6V19_RS13790	COG2217	Heavy metal translocating P-type atpase
K6V19_RS13795	COG0321	lipoyl(octanoyl) transferase activity
K6V19_RS13810	COG3250	beta-galactosidase activity
K6V19_RS13845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6V19_RS13865	COG1678	Uncharacterized ACR, COG1678
K6V19_RS13880	COG4771	TonB-dependent receptor
K6V19_RS13890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6V19_RS13895	COG1924	4 iron, 4 sulfur cluster binding
K6V19_RS13905	COG1091	dTDP-4-dehydrorhamnose reductase activity
K6V19_RS13915	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6V19_RS13920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6V19_RS13935	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6V19_RS13940	COG0540	Belongs to the ATCase OTCase family
K6V19_RS13950	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6V19_RS13955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6V19_RS13960	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K6V19_RS13975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6V19_RS13980	COG2205	protein histidine kinase activity
K6V19_RS14040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6V19_RS14060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6V19_RS14070	COG0673	inositol 2-dehydrogenase activity
K6V19_RS14080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6V19_RS14080	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6V19_RS14085	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6V19_RS14105	COG5002	protein histidine kinase activity
K6V19_RS14105	COG0784	Response regulator, receiver
K6V19_RS14110	COG2949	membrane
K6V19_RS14115	COG2223	nitrite transmembrane transporter activity
K6V19_RS14130	COG0671	phosphoesterase, PA-phosphatase related
K6V19_RS14140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V19_RS14150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6V19_RS14155	COG0351	phosphomethylpyrimidine kinase
K6V19_RS14175	COG1733	regulation of RNA biosynthetic process
K6V19_RS14215	COG2814	Major facilitator Superfamily
K6V19_RS14215	COG0477	Major facilitator Superfamily
K6V19_RS14220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V19_RS14220	COG3153	acetyltransferase
K6V19_RS14225	COG0450	alkyl hydroperoxide reductase
K6V19_RS14230	COG0724	RNA recognition motif
K6V19_RS14235	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K6V19_RS14245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6V19_RS14255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K6V19_RS14270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6V19_RS14305	COG1252	NADH dehydrogenase
K6V19_RS14320	COG1690	Belongs to the RtcB family
K6V19_RS14345	COG2076	Multidrug Resistance protein
K6V19_RS14355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V19_RS14370	COG1904	glucuronate isomerase
K6V19_RS14375	COG1609	Transcriptional regulator
K6V19_RS14380	COG0246	Mannitol dehydrogenase
K6V19_RS14440	COG1216	Glycosyl transferase, family 2
K6V19_RS14445	COG0438	transferase activity, transferring glycosyl groups
K6V19_RS14450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6V19_RS14455	COG0297	glycogen (starch) synthase activity
K6V19_RS14455	COG0438	transferase activity, transferring glycosyl groups
K6V19_RS14460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V19_RS14485	COG0513	Belongs to the DEAD box helicase family
K6V19_RS14490	COG0560	Phosphoserine phosphatase
K6V19_RS14490	COG3830	Belongs to the UPF0237 family
K6V19_RS14505	COG0343	queuine tRNA-ribosyltransferase activity
K6V19_RS14510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6V19_RS14515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6V19_RS14540	COG0156	8-amino-7-oxononanoate synthase activity
K6V19_RS14545	COG1597	lipid kinase activity
K6V19_RS14550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6V19_RS14565	COG2957	Belongs to the agmatine deiminase family
K6V19_RS14585	COG1132	(ABC) transporter
K6V19_RS14630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6V19_RS14640	COG1538	Outer membrane efflux protein
K6V19_RS14660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V19_RS14675	COG0543	2 iron, 2 sulfur cluster binding
K6V19_RS14680	COG0167	dihydroorotate dehydrogenase activity
K6V19_RS14685	COG0336	Belongs to the RNA methyltransferase TrmD family
K6V19_RS14690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6V19_RS14695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6V19_RS14735	COG0326	Molecular chaperone. Has ATPase activity
K6V19_RS14740	COG0542	response to heat
K6V19_RS14785	COG2304	oxidoreductase activity
K6V19_RS14800	COG0714	Associated with various cellular activities
K6V19_RS14815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V19_RS14820	COG0552	protein localization to endoplasmic reticulum
K6V19_RS14830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6V19_RS14835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6V19_RS14840	COG1058	Belongs to the CinA family
K6V19_RS14840	COG1546	Belongs to the CinA family
K6V19_RS14845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6V19_RS14860	COG1733	regulation of RNA biosynthetic process
K6V19_RS14910	COG2204	response regulator
K6V19_RS14935	COG3961	Belongs to the TPP enzyme family
K6V19_RS14945	COG2814	Major facilitator Superfamily
K6V19_RS14965	COG3408	Glycogen debranching enzyme
K6V19_RS14980	COG1475	DNA binding
K6V19_RS15045	COG5002	protein histidine kinase activity
K6V19_RS15050	COG0745	RESPONSE REGULATOR receiver
K6V19_RS15055	COG0442	prolyl-tRNA aminoacylation
K6V19_RS15065	COG3291	Pkd domain containing protein
K6V19_RS15155	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS15165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V19_RS15175	COG1538	Outer membrane efflux protein
K6V19_RS15195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V19_RS15210	COG0300	oxidoreductase activity
K6V19_RS15220	COG2205	protein histidine kinase activity
K6V19_RS15245	COG1475	DNA binding
K6V19_RS15250	COG3969	phosphoadenosine phosphosulfate
K6V19_RS15275	COG3275	phosphorelay sensor kinase activity
K6V19_RS15285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6V19_RS15335	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6V19_RS15360	COG4999	Histidine kinase
K6V19_RS15360	COG3850	Histidine kinase
K6V19_RS15360	COG3437	response regulator, receiver
K6V19_RS15360	COG2205	protein histidine kinase activity
K6V19_RS15370	COG0352	thiamine-phosphate diphosphorylase activity
K6V19_RS15375	COG2022	thiamine diphosphate biosynthetic process
K6V19_RS15380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6V19_RS15390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6V19_RS15395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6V19_RS15400	COG0352	thiamine-phosphate diphosphorylase activity
K6V19_RS15415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6V19_RS15415	COG0574	Belongs to the PEP-utilizing enzyme family
K6V19_RS15420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6V19_RS15425	COG0564	pseudouridine synthase activity
K6V19_RS15460	COG0024	Methionine aminopeptidase
K6V19_RS15490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6V19_RS15500	COG0481	GTPase activity
K6V19_RS15520	COG0708	Exodeoxyribonuclease III
K6V19_RS15530	COG1914	H( )-stimulated, divalent metal cation uptake system
K6V19_RS15545	COG0217	transcriptional regulatory protein
K6V19_RS15550	COG0072	phenylalanine-tRNA ligase activity
K6V19_RS15550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6V19_RS15555	COG0305	Participates in initiation and elongation during chromosome replication
K6V19_RS15560	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6V19_RS15580	COG2059	Chromate
K6V19_RS15585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6V19_RS15590	COG4657	Part of a membrane complex involved in electron transport
K6V19_RS15595	COG4660	Part of a membrane complex involved in electron transport
K6V19_RS15600	COG4659	FMN binding
K6V19_RS15605	COG4658	electron transport chain
K6V19_RS15610	COG4656	Part of a membrane complex involved in electron transport
K6V19_RS15630	COG0504	CTP synthase activity
K6V19_RS15640	COG0534	Mate efflux family protein
K6V19_RS15645	COG0823	Involved in the tonB-independent uptake of proteins
K6V19_RS15645	COG1506	peptidase
K6V19_RS15665	COG1695	Transcriptional regulator
K6V19_RS15685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6V19_RS15695	COG2197	response regulator
K6V19_RS15700	COG4585	Histidine kinase
K6V19_RS15715	COG1388	LysM domain
K6V19_RS15715	COG3942	CHAP domain
K6V19_RS15745	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V19_RS15750	COG0556	nucleotide-excision repair
K6V19_RS15770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6V19_RS15780	COG0842	Transport permease protein
K6V19_RS15785	COG0842	Transport permease protein
K6V19_RS15790	COG1131	(ABC) transporter
K6V19_RS15810	COG0228	four-way junction DNA binding
K6V19_RS15825	COG4977	sequence-specific DNA binding
K6V19_RS15825	COG1917	Cupin 2, conserved barrel domain protein
K6V19_RS15830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V19_RS15885	COG0745	RESPONSE REGULATOR receiver
K6V19_RS15890	COG3850	Histidine kinase
K6V19_RS15890	COG5002	protein histidine kinase activity
K6V19_RS15895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V19_RS15900	COG0724	RNA recognition motif
K6V19_RS15915	COG1177	transmembrane transport
K6V19_RS15920	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6V19_RS15930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V19_RS15935	COG0058	SHG alpha-glucan phosphorylase activity
K6V19_RS15945	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V19_RS15965	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K6V19_RS16005	COG3328	transposase activity
K6V19_RS16040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6V19_RS16045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V19_RS16055	COG1032	radical SAM domain protein
K6V19_RS16085	COG2365	Tyrosine phosphatase family
K6V19_RS16090	COG0363	glucosamine-6-phosphate deaminase activity
K6V19_RS16095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V19_RS16110	COG4948	Mandelate Racemase Muconate Lactonizing
K6V19_RS16125	COG1295	ribonuclease BN
K6V19_RS16130	COG0778	Nitroreductase
K6V19_RS16135	COG0307	riboflavin synthase, alpha
K6V19_RS16140	COG0704	Plays a role in the regulation of phosphate uptake
K6V19_RS16145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6V19_RS16150	COG0581	inorganic phosphate transmembrane transporter activity
K6V19_RS16155	COG0573	inorganic phosphate transmembrane transporter activity
K6V19_RS16165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V19_RS16185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6V19_RS16205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V19_RS16220	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V19_RS16265	COG0438	transferase activity, transferring glycosyl groups
K6V19_RS16290	COG0438	transferase activity, transferring glycosyl groups
K6V19_RS16300	COG1216	Glycosyl transferase, family 2
K6V19_RS16300	COG1442	glycosyl transferase family 8
K6V19_RS16335	COG3392	D12 class N6 adenine-specific DNA methyltransferase
K6V19_RS16605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6V19_RS16610	COG0167	dihydroorotate dehydrogenase activity
K6V19_RS16620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6V19_RS16645	COG0497	DNA recombination
K6V19_RS16680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V19_RS16680	COG0321	lipoyl(octanoyl) transferase activity
K6V19_RS16700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V19_RS16720	COG0019	diaminopimelate decarboxylase activity
K6V19_RS16725	COG0527	aspartate kinase activity
K6V19_RS16730	COG2884	Cell division ATP-binding protein ftsE
K6V19_RS16735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6V19_RS16735	COG0140	phosphoribosyl-ATP diphosphatase activity
K6V19_RS16740	COG0107	imidazoleglycerol-phosphate synthase activity
K6V19_RS16745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6V19_RS16750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6V19_RS16755	COG0788	formyltetrahydrofolate deformylase activity
K6V19_RS16770	COG0306	phosphate transporter
K6V19_RS16780	COG0586	Pfam SNARE associated Golgi protein
K6V19_RS16790	COG0110	maltose O-acetyltransferase activity
K6V19_RS16810	COG2819	hydrolase of the alpha beta superfamily
K6V19_RS16815	COG3059	membrane
K6V19_RS16820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V19_RS16840	COG1620	l-lactate permease
K6V19_RS16870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V19_RS16875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V19_RS16935	COG1216	Glycosyl transferase, family 2
K6V19_RS16940	COG5039	Polysaccharide pyruvyl transferase
K6V19_RS17020	COG0702	epimerase
K6V19_RS17025	COG4771	TonB-dependent receptor
K6V19_RS17030	COG2814	Major facilitator Superfamily
K6V19_RS17050	COG2140	Oxalate decarboxylase
K6V19_RS17055	COG0662	Cupin 2, conserved barrel domain protein
K6V19_RS17055	COG2207	Transcriptional regulator
K6V19_RS17060	COG1312	Catalyzes the dehydration of D-mannonate
K6V19_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS17070	COG1609	Transcriptional regulator
K6V19_RS17095	COG0667	Aldo Keto reductase
K6V19_RS17105	COG0656	L-ascorbic acid biosynthetic process
K6V19_RS17130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6V19_RS17145	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS17165	COG1979	alcohol dehydrogenase
K6V19_RS17170	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS17175	COG0667	Aldo Keto reductase
K6V19_RS17190	COG0667	Aldo Keto reductase
K6V19_RS17215	COG4771	TonB-dependent receptor
K6V19_RS17240	COG2207	Transcriptional regulator
K6V19_RS17240	COG4753	response regulator
K6V19_RS17255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6V19_RS17255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6V19_RS17355	COG0656	L-ascorbic acid biosynthetic process
K6V19_RS17360	COG1064	alcohol dehydrogenase
K6V19_RS17385	COG0456	acetyltransferase
K6V19_RS17415	COG0776	regulation of translation
K6V19_RS17420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6V19_RS17435	COG0702	epimerase
K6V19_RS17440	COG4771	TonB-dependent receptor
K6V19_RS17450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6V19_RS17455	COG0745	RESPONSE REGULATOR receiver
K6V19_RS17455	COG0745	RESPONSE REGULATOR receiver
K6V19_RS17455	COG3292	Two component regulator propeller
K6V19_RS17455	COG2205	protein histidine kinase activity
K6V19_RS17455	COG2205	protein histidine kinase activity
K6V19_RS17455	COG3292	Two component regulator propeller
K6V19_RS17480	COG0628	permease
K6V19_RS17485	COG1215	transferase activity, transferring glycosyl groups
K6V19_RS17500	COG0436	Aminotransferase
K6V19_RS17520	COG0488	(ABC) transporter
K6V19_RS17540	COG1408	metallophosphoesterase
K6V19_RS17545	COG0745	RESPONSE REGULATOR receiver
K6V19_RS17575	COG3033	Beta-eliminating lyase
K6V19_RS17580	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V19_RS17650	COG0629	single-stranded DNA binding
K6V19_RS17665	COG1530	ribonuclease E activity
K6V19_RS17670	COG2755	lipolytic protein G-D-S-L family
K6V19_RS17690	COG1979	alcohol dehydrogenase
K6V19_RS17725	COG2985	domain, Protein
K6V19_RS17740	COG2204	response regulator
K6V19_RS17750	COG0784	Response regulator, receiver
K6V19_RS17750	COG2205	protein histidine kinase activity
K6V19_RS17750	COG5002	protein histidine kinase activity
K6V19_RS17760	COG0577	efflux transmembrane transporter activity
K6V19_RS17760	COG1136	(ABC) transporter
K6V19_RS17780	COG1136	(ABC) transporter
K6V19_RS17805	COG1629	transport
K6V19_RS17825	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6V19_RS17830	COG0295	cytidine deaminase activity
K6V19_RS17835	COG0662	Cupin 2, conserved barrel domain protein
K6V19_RS17835	COG2207	Transcriptional regulator
K6V19_RS17840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V19_RS17850	COG0488	(ABC) transporter
K6V19_RS17870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V19_RS17885	COG0686	Belongs to the AlaDH PNT family
K6V19_RS17910	COG1595	DNA-templated transcription, initiation
K6V19_RS17925	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6V19_RS17930	COG4206	TonB-dependent receptor
K6V19_RS17930	COG1629	transport
K6V19_RS17950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6V19_RS17955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6V19_RS17980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V19_RS17985	COG1741	Belongs to the pirin family
K6V19_RS17990	COG0259	pyridoxamine-phosphate oxidase activity
K6V19_RS18005	COG0346	lactoylglutathione lyase activity
K6V19_RS18020	COG0471	metal ion transport
K6V19_RS18020	COG0490	domain, Protein
K6V19_RS18040	COG0516	GMP reductase activity
K6V19_RS18040	COG0517	IMP dehydrogenase activity
K6V19_RS18045	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS18050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6V19_RS18085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6V19_RS18085	COG1918	ferrous iron import across plasma membrane
K6V19_RS18090	COG0037	tRNA processing
K6V19_RS18105	COG0784	Response regulator, receiver
K6V19_RS18105	COG5002	protein histidine kinase activity
K6V19_RS18105	COG2198	Histidine kinase
K6V19_RS18110	COG2205	protein histidine kinase activity
K6V19_RS18110	COG2202	Pas domain
K6V19_RS18115	COG0534	Mate efflux family protein
K6V19_RS18120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6V19_RS18125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6V19_RS18165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6V19_RS18200	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V19_RS18215	COG3119	arylsulfatase activity
K6V19_RS18225	COG3250	beta-galactosidase activity
K6V19_RS18265	COG3250	beta-galactosidase activity
K6V19_RS18270	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS18275	COG3119	arylsulfatase activity
K6V19_RS18280	COG0702	epimerase
K6V19_RS18285	COG4771	TonB-dependent receptor
K6V19_RS18320	COG3119	arylsulfatase activity
K6V19_RS18325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6V19_RS18330	COG0668	transmembrane transport
K6V19_RS18335	COG0745	RESPONSE REGULATOR receiver
K6V19_RS18335	COG2205	protein histidine kinase activity
K6V19_RS18335	COG0745	RESPONSE REGULATOR receiver
K6V19_RS18335	COG2205	protein histidine kinase activity
K6V19_RS18335	COG3292	Two component regulator propeller
K6V19_RS18335	COG3292	Two component regulator propeller
K6V19_RS18340	COG3119	arylsulfatase activity
K6V19_RS18345	COG1830	Aldolase
K6V19_RS18350	COG0588	phosphoglycerate mutase activity
K6V19_RS18355	COG2205	protein histidine kinase activity
K6V19_RS18355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V19_RS18365	COG1119	ATPase activity
K6V19_RS18370	COG1523	belongs to the glycosyl hydrolase 13 family
K6V19_RS18375	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6V19_RS18415	COG0438	transferase activity, transferring glycosyl groups
K6V19_RS18420	COG1216	Glycosyl transferase, family 2
K6V19_RS18420	COG1442	glycosyl transferase family 8
K6V19_RS18430	COG0438	transferase activity, transferring glycosyl groups
K6V19_RS18500	COG1132	(ABC) transporter
K6V19_RS18560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6V19_RS18570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6V19_RS18575	COG0126	phosphoglycerate kinase activity
K6V19_RS18595	COG0424	maF-like protein
K6V19_RS18615	COG0778	Nitroreductase
K6V19_RS18625	COG0288	reversible hydration of carbon dioxide
K6V19_RS18645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V19_RS18655	COG0511	ligase activity, forming carbon-carbon bonds
K6V19_RS18655	COG5016	pyruvate
K6V19_RS18660	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6V19_RS18665	COG0457	Tetratricopeptide repeat
K6V19_RS18670	COG0366	Alpha amylase catalytic
K6V19_RS18680	COG0191	fructose-bisphosphate aldolase activity
K6V19_RS18690	COG0254	rRNA binding
K6V19_RS18695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6V19_RS18710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V19_RS18715	COG1629	transport
K6V19_RS18715	COG4206	TonB-dependent receptor
K6V19_RS18720	COG1609	Transcriptional regulator
K6V19_RS18730	COG1554	hydrolase, family 65, central catalytic
K6V19_RS18735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V19_RS18775	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6V19_RS18790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K6V19_RS18805	COG1280	lysine exporter protein (LysE YggA)
K6V19_RS18810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6V19_RS18810	COG0047	phosphoribosylformylglycinamidine synthase activity
K6V19_RS18815	COG2205	protein histidine kinase activity
K6V19_RS18815	COG0745	RESPONSE REGULATOR receiver
K6V19_RS18815	COG3292	Two component regulator propeller
K6V19_RS18830	COG1649	PFAM Uncharacterised BCR, COG1649
K6V19_RS18835	COG2198	Histidine kinase
K6V19_RS18835	COG0784	Response regulator, receiver
K6V19_RS18835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V19_RS18835	COG2205	protein histidine kinase activity
K6V19_RS18855	COG1966	Carbon starvation protein
K6V19_RS18860	COG1649	PFAM Uncharacterised BCR, COG1649
K6V19_RS18880	COG2113	Glycine betaine
K6V19_RS18885	COG4176	ABC-type proline glycine betaine transport system permease component
K6V19_RS18915	COG2205	protein histidine kinase activity
K6V19_RS18915	COG0745	RESPONSE REGULATOR receiver
K6V19_RS18915	COG3292	Two component regulator propeller
K6V19_RS18925	COG3119	arylsulfatase activity
K6V19_RS18935	COG3119	arylsulfatase activity
K6V19_RS18955	COG3119	arylsulfatase activity
K6V19_RS18975	COG4771	TonB-dependent receptor
K6V19_RS18980	COG3292	Two component regulator propeller
K6V19_RS18980	COG2205	protein histidine kinase activity
K6V19_RS18980	COG0745	RESPONSE REGULATOR receiver
K6V19_RS19010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6V19_RS19010	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K6V19_RS19020	COG1621	beta-fructofuranosidase activity
K6V19_RS19045	COG0702	epimerase
K6V19_RS19050	COG4771	TonB-dependent receptor
K6V19_RS19060	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6V19_RS19090	COG3279	Response regulator of the LytR AlgR family
K6V19_RS19095	COG3275	phosphorelay sensor kinase activity
K6V19_RS19130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6V19_RS19145	COG0484	heat shock protein binding
K6V19_RS19150	COG2202	Pas domain
K6V19_RS19150	COG2205	protein histidine kinase activity
K6V19_RS19160	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V19_RS19165	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V19_RS19195	COG4206	TonB-dependent receptor
K6V19_RS19195	COG1629	transport
K6V19_RS19245	COG0459	protein refolding
K6V19_RS19250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6V19_RS19280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6V19_RS19290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6V19_RS19305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6V19_RS19350	COG0671	phosphoesterase, PA-phosphatase related
K6V19_RS19365	COG0066	3-isopropylmalate dehydratase activity
K6V19_RS19370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6V19_RS19375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6V19_RS19430	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS19435	COG0439	Biotin carboxylase
K6V19_RS19440	COG5016	pyruvate
K6V19_RS19440	COG0511	ligase activity, forming carbon-carbon bonds
K6V19_RS19445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V19_RS19460	COG2873	o-acetylhomoserine
K6V19_RS19490	COG0534	Mate efflux family protein
K6V19_RS19515	COG2814	Major facilitator Superfamily
K6V19_RS19530	COG0281	malic enzyme
K6V19_RS19530	COG0280	phosphate acetyltransferase
K6V19_RS19540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6V19_RS19555	COG1505	serine-type exopeptidase activity
K6V19_RS19565	COG0006	proline dipeptidase activity
K6V19_RS19580	COG0617	tRNA 3'-terminal CCA addition
K6V19_RS19580	COG3620	sequence-specific DNA binding
K6V19_RS19580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6V19_RS19635	COG4974	Belongs to the 'phage' integrase family
K6V19_RS19670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6V19_RS19670	COG0551	DNA topoisomerase type I activity
K6V19_RS19690	COG0784	Response regulator, receiver
K6V19_RS19690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6V19_RS19690	COG2198	Histidine kinase
K6V19_RS19690	COG2205	protein histidine kinase activity
K6V19_RS19815	COG0358	DNA primase activity
K6V19_RS19885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V19_RS19890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6V19_RS19905	COG0632	four-way junction helicase activity
K6V19_RS19910	COG0673	inositol 2-dehydrogenase activity
K6V19_RS19925	COG1272	protein, Hemolysin III
K6V19_RS19930	COG1328	CTP reductase activity
K6V19_RS19930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6V19_RS19940	COG1011	Hydrolase
K6V19_RS19950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V19_RS19965	COG0750	zinc metalloprotease
K6V19_RS19980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6V19_RS19985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6V19_RS20005	COG0194	GDP metabolic process
K6V19_RS20010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6V19_RS20025	COG1408	metallophosphoesterase
K6V19_RS20030	COG1575	Belongs to the MenA family. Type 1 subfamily
K6V19_RS20035	COG1088	dTDP-glucose 4,6-dehydratase activity
K6V19_RS20040	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6V19_RS20055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6V19_RS20065	COG2204	response regulator
K6V19_RS20070	COG0488	(ABC) transporter
K6V19_RS20115	COG1595	DNA-templated transcription, initiation
K6V19_RS20125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6V19_RS20130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6V19_RS20140	COG1522	sequence-specific DNA binding
K6V19_RS20170	COG0811	peptide transport
K6V19_RS20180	COG0084	hydrolase, TatD family'
K6V19_RS20205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6V19_RS20210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6V19_RS20215	COG0205	6-phosphofructokinase activity
K6V19_RS20220	COG1028	Short-chain dehydrogenase reductase Sdr
K6V19_RS20235	COG0372	Belongs to the citrate synthase family
K6V19_RS20240	COG0538	isocitrate dehydrogenase activity
K6V19_RS20245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6V19_RS20250	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K6V19_RS20255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6V19_RS20270	COG0028	Belongs to the TPP enzyme family
K6V19_RS20275	COG0129	dihydroxy-acid dehydratase activity
K6V19_RS20280	COG1047	Peptidyl-prolyl cis-trans
K6V19_RS20285	COG3681	Belongs to the UPF0597 family
K6V19_RS20335	COG2885	chlorophyll binding
K6V19_RS20350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V19_RS20350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V19_RS20355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V19_RS20360	COG2985	domain, Protein
K6V19_RS20360	COG0569	domain protein
K6V19_RS20385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6V19_RS20390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6V19_RS20395	COG0166	Belongs to the GPI family
K6V19_RS20405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V19_RS20410	COG2431	L-lysine efflux transmembrane transporter activity
K6V19_RS20425	COG2502	aspartate--ammonia ligase
K6V19_RS20430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6V19_RS20445	COG3876	Protein conserved in bacteria
K6V19_RS20450	COG0673	inositol 2-dehydrogenase activity
K6V19_RS20460	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6V19_RS20535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6V19_RS20540	COG1968	undecaprenyl-diphosphatase activity
K6V19_RS20600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner