locus-tag	class	description
INE81_RS00005	COG4771	TonB-dependent receptor
INE81_RS00025	COG4771	TonB-dependent receptor
INE81_RS00045	COG2095	MarC family integral membrane protein
INE81_RS00060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE81_RS00070	COG1435	thymidine kinase activity
INE81_RS00075	COG0628	permease
INE81_RS00085	COG4974	Belongs to the 'phage' integrase family
INE81_RS00205	COG3344	reverse transcriptase
INE81_RS00395	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
INE81_RS00405	COG0517	IMP dehydrogenase activity
INE81_RS00415	COG1309	transcriptional regulator
INE81_RS00425	COG0551	DNA topoisomerase type I activity
INE81_RS00425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE81_RS00465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INE81_RS00490	COG0456	acetyltransferase
INE81_RS00520	COG3973	AAA domain
INE81_RS00525	COG4977	sequence-specific DNA binding
INE81_RS00600	COG0534	Mate efflux family protein
INE81_RS00610	COG0668	transmembrane transport
INE81_RS00630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INE81_RS00635	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
INE81_RS00640	COG0460	homoserine dehydrogenase
INE81_RS00640	COG0527	aspartate kinase activity
INE81_RS00645	COG0252	asparaginase activity
INE81_RS00650	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INE81_RS00655	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
INE81_RS00665	COG0671	phosphoesterase, PA-phosphatase related
INE81_RS00670	COG4771	TonB-dependent receptor
INE81_RS00680	COG0826	peptidase U32
INE81_RS00710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE81_RS00710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE81_RS00765	COG0582	viral genome integration into host DNA
INE81_RS00790	COG4974	Belongs to the 'phage' integrase family
INE81_RS00825	COG2205	protein histidine kinase activity
INE81_RS00835	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
INE81_RS00840	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
INE81_RS00845	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
INE81_RS00855	COG2204	response regulator
INE81_RS00865	COG0446	pyridine nucleotide-disulphide oxidoreductase
INE81_RS00890	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS00895	COG0737	Belongs to the 5'-nucleotidase family
INE81_RS00900	COG0737	Belongs to the 5'-nucleotidase family
INE81_RS00905	COG0335	large ribosomal subunit rRNA binding
INE81_RS00920	COG1940	carbohydrate kinase activity
INE81_RS00925	COG1136	(ABC) transporter
INE81_RS00930	COG1136	(ABC) transporter
INE81_RS00930	COG0577	efflux transmembrane transporter activity
INE81_RS00940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE81_RS01005	COG2996	Protein conserved in bacteria
INE81_RS01010	COG0039	L-malate dehydrogenase activity
INE81_RS01015	COG0534	Mate efflux family protein
INE81_RS01030	COG0076	glutamate decarboxylase activity
INE81_RS01035	COG2066	Belongs to the glutaminase family
INE81_RS01045	COG0531	amino acid
INE81_RS01080	COG3250	beta-galactosidase activity
INE81_RS01085	COG3401	FG-GAP repeat protein
INE81_RS01095	COG4771	TonB-dependent receptor
INE81_RS01110	COG0702	epimerase
INE81_RS01160	COG0235	Class ii aldolase
INE81_RS01170	COG4806	L-rhamnose isomerase
INE81_RS01175	COG1070	Carbohydrate kinase
INE81_RS01185	COG3401	FG-GAP repeat protein
INE81_RS01195	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE81_RS01265	COG0137	argininosuccinate synthase activity
INE81_RS01275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INE81_RS01290	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS01295	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS01310	COG0445	tRNA wobble uridine modification
INE81_RS01320	COG1629	transport
INE81_RS01330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INE81_RS01335	COG1396	sequence-specific DNA binding
INE81_RS01335	COG1917	Cupin 2, conserved barrel domain protein
INE81_RS01340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
INE81_RS01350	COG1649	PFAM Uncharacterised BCR, COG1649
INE81_RS01370	COG1629	transport
INE81_RS01430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INE81_RS01440	COG2890	protein-(glutamine-N5) methyltransferase activity
INE81_RS01445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE81_RS01445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE81_RS01460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INE81_RS01465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
INE81_RS01480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INE81_RS01490	COG5002	protein histidine kinase activity
INE81_RS01490	COG2198	Histidine kinase
INE81_RS01490	COG0784	Response regulator, receiver
INE81_RS01500	COG0436	Aminotransferase
INE81_RS01505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
INE81_RS01510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INE81_RS01515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INE81_RS01540	COG0564	pseudouridine synthase activity
INE81_RS01550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
INE81_RS01555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INE81_RS01560	COG1785	Belongs to the alkaline phosphatase family
INE81_RS01590	COG2003	Belongs to the UPF0758 family
INE81_RS01600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INE81_RS01605	COG0280	phosphate acetyltransferase
INE81_RS01625	COG1380	Effector of murein hydrolase LrgA
INE81_RS01630	COG1346	cytolysis
INE81_RS01645	COG0312	modulator of DNA gyrase
INE81_RS01650	COG0312	modulator of DNA gyrase
INE81_RS01655	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
INE81_RS01660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INE81_RS01665	COG2205	protein histidine kinase activity
INE81_RS01670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INE81_RS01680	COG0733	neurotransmitter:sodium symporter activity
INE81_RS01690	COG1136	(ABC) transporter
INE81_RS01695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INE81_RS01700	COG0589	response to stress
INE81_RS01700	COG0475	glutathione-regulated potassium exporter activity
INE81_RS01705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INE81_RS01745	COG1649	PFAM Uncharacterised BCR, COG1649
INE81_RS01765	COG1629	transport
INE81_RS01785	COG3876	Protein conserved in bacteria
INE81_RS01790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE81_RS01795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
INE81_RS01800	COG1215	transferase activity, transferring glycosyl groups
INE81_RS01820	COG3876	Protein conserved in bacteria
INE81_RS01840	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
INE81_RS01845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
INE81_RS01855	COG0423	glycine-tRNA ligase activity
INE81_RS01890	COG4771	TonB-dependent receptor
INE81_RS01895	COG0702	epimerase
INE81_RS01900	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS01955	COG2954	triphosphatase activity
INE81_RS01970	COG0662	Cupin 2, conserved barrel domain protein
INE81_RS01970	COG2207	Transcriptional regulator
INE81_RS01980	COG0612	Peptidase, M16
INE81_RS01985	COG1022	Amp-dependent synthetase and ligase
INE81_RS01990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INE81_RS02015	COG3250	beta-galactosidase activity
INE81_RS02025	COG4942	peptidase
INE81_RS02040	COG0756	dUTP diphosphatase activity
INE81_RS02060	COG1595	DNA-templated transcription, initiation
INE81_RS02070	COG1414	Transcriptional regulator
INE81_RS02095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE81_RS02095	COG1333	cytochrome c biogenesis protein
INE81_RS02105	COG2376	Dihydroxyacetone kinase
INE81_RS02110	COG2376	Dihydroxyacetone kinase
INE81_RS02125	COG0657	acetylesterase activity
INE81_RS02125	COG2755	lipolytic protein G-D-S-L family
INE81_RS02150	COG1629	transport
INE81_RS02150	COG4206	TonB-dependent receptor
INE81_RS02235	COG0275	rRNA processing
INE81_RS02245	COG0768	penicillin binding
INE81_RS02250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INE81_RS02255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE81_RS02260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INE81_RS02265	COG0772	Belongs to the SEDS family
INE81_RS02270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INE81_RS02275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INE81_RS02285	COG0849	cell division
INE81_RS02290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INE81_RS02295	COG1610	YqeY-like protein
INE81_RS02300	COG1381	Involved in DNA repair and RecF pathway recombination
INE81_RS02310	COG0268	Binds directly to 16S ribosomal RNA
INE81_RS02315	COG0187	DNA topoisomerase II activity
INE81_RS02325	COG3594	Acyltransferase
INE81_RS02340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
INE81_RS02360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INE81_RS02370	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
INE81_RS02375	COG2217	Heavy metal translocating P-type atpase
INE81_RS02385	COG0393	Putative heavy-metal-binding
INE81_RS02395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INE81_RS02400	COG0719	Fe-S assembly protein
INE81_RS02405	COG0396	ATPase activity
INE81_RS02410	COG0719	Fe-S assembly protein
INE81_RS02420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INE81_RS02425	COG0195	Participates in both transcription termination and antitermination
INE81_RS02430	COG0779	Required for maturation of 30S ribosomal subunits
INE81_RS02445	COG3250	beta-galactosidase activity
INE81_RS02495	COG0745	RESPONSE REGULATOR receiver
INE81_RS02495	COG2205	protein histidine kinase activity
INE81_RS02495	COG3292	Two component regulator propeller
INE81_RS02565	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS02590	COG4771	TonB-dependent receptor
INE81_RS02605	COG0738	Major facilitator superfamily
INE81_RS02615	COG1070	Carbohydrate kinase
INE81_RS02620	COG0235	Class ii aldolase
INE81_RS02625	COG1454	alcohol dehydrogenase
INE81_RS02640	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS02680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INE81_RS02685	COG1166	arginine decarboxylase activity
INE81_RS02690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INE81_RS02700	COG3341	Caulimovirus viroplasmin
INE81_RS02700	COG0328	RNA-DNA hybrid ribonuclease activity
INE81_RS02710	COG1132	(ABC) transporter
INE81_RS02715	COG1215	transferase activity, transferring glycosyl groups
INE81_RS02735	COG1216	Glycosyl transferase, family 2
INE81_RS02740	COG3475	LICD family
INE81_RS02750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE81_RS02755	COG1215	transferase activity, transferring glycosyl groups
INE81_RS02780	COG0463	Glycosyl transferase, family 2
INE81_RS02800	COG0859	PFAM glycosyl transferase family 9
INE81_RS02810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE81_RS02820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INE81_RS02825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INE81_RS02830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INE81_RS02835	COG0571	ribonuclease III activity
INE81_RS02840	COG0205	6-phosphofructokinase activity
INE81_RS02855	COG0482	sulfurtransferase activity
INE81_RS02870	COG0561	phosphatase activity
INE81_RS02875	COG0215	cysteine-tRNA ligase activity
INE81_RS02880	COG3119	arylsulfatase activity
INE81_RS02885	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE81_RS02915	COG1538	Outer membrane efflux protein
INE81_RS02920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE81_RS02935	COG0745	RESPONSE REGULATOR receiver
INE81_RS02935	COG2205	protein histidine kinase activity
INE81_RS02935	COG3292	Two component regulator propeller
INE81_RS02940	COG3119	arylsulfatase activity
INE81_RS02970	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE81_RS02975	COG1917	Cupin 2, conserved barrel domain protein
INE81_RS02975	COG4977	sequence-specific DNA binding
INE81_RS02980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
INE81_RS02985	COG5012	cobalamin binding
INE81_RS03010	COG0745	RESPONSE REGULATOR receiver
INE81_RS03010	COG2205	protein histidine kinase activity
INE81_RS03010	COG3292	Two component regulator propeller
INE81_RS03015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE81_RS03070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INE81_RS03080	COG0681	Belongs to the peptidase S26 family
INE81_RS03095	COG3401	FG-GAP repeat protein
INE81_RS03125	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS03130	COG0612	Peptidase, M16
INE81_RS03165	COG3591	Belongs to the peptidase S1B family
INE81_RS03180	COG2255	four-way junction helicase activity
INE81_RS03190	COG0805	protein transport
INE81_RS03195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INE81_RS03235	COG2715	membrane protein required for spore maturation
INE81_RS03240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INE81_RS03255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE81_RS03260	COG0322	excinuclease ABC activity
INE81_RS03270	COG1694	Mazg nucleotide pyrophosphohydrolase
INE81_RS03275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INE81_RS03285	COG0142	geranyltranstransferase activity
INE81_RS03290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE81_RS03290	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE81_RS03310	COG1045	serine acetyltransferase
INE81_RS03315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE81_RS03315	COG0116	Belongs to the methyltransferase superfamily
INE81_RS03325	COG1506	peptidase
INE81_RS03325	COG0823	Involved in the tonB-independent uptake of proteins
INE81_RS03340	COG1238	metal cluster binding
INE81_RS03355	COG1121	(ABC) transporter
INE81_RS03365	COG0726	polysaccharide deacetylase
INE81_RS03370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INE81_RS03385	COG1028	Short-chain dehydrogenase reductase Sdr
INE81_RS03390	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
INE81_RS03400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INE81_RS03405	COG0084	hydrolase, TatD family'
INE81_RS03410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INE81_RS03430	COG1611	Belongs to the LOG family
INE81_RS03445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INE81_RS03455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INE81_RS03460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE81_RS03465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INE81_RS03470	COG1968	undecaprenyl-diphosphatase activity
INE81_RS03480	COG2177	Part of the ABC transporter FtsEX involved in
INE81_RS03485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
INE81_RS03500	COG4771	TonB-dependent receptor
INE81_RS03505	COG0702	epimerase
INE81_RS03535	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
INE81_RS03540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE81_RS03545	COG3458	cephalosporin-C deacetylase activity
INE81_RS03555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE81_RS03565	COG0427	acetyl-CoA hydrolase
INE81_RS03575	COG2814	Major facilitator Superfamily
INE81_RS03585	COG1595	DNA-templated transcription, initiation
INE81_RS03595	COG4771	TonB-dependent receptor
INE81_RS03600	COG0702	epimerase
INE81_RS03620	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS03665	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE81_RS03670	COG1629	transport
INE81_RS03675	COG0702	epimerase
INE81_RS03715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
INE81_RS03720	COG1501	Belongs to the glycosyl hydrolase 31 family
INE81_RS03735	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE81_RS03760	COG4771	TonB-dependent receptor
INE81_RS03770	COG1629	transport
INE81_RS03775	COG0702	epimerase
INE81_RS03780	COG0745	RESPONSE REGULATOR receiver
INE81_RS03780	COG3292	Two component regulator propeller
INE81_RS03780	COG2205	protein histidine kinase activity
INE81_RS03785	COG1592	Rubrerythrin
INE81_RS03790	COG0659	secondary active sulfate transmembrane transporter activity
INE81_RS03795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE81_RS03795	COG0731	radical SAM domain protein
INE81_RS03815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
INE81_RS03850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE81_RS03855	COG0495	leucyl-tRNA aminoacylation
INE81_RS03905	COG4771	TonB-dependent receptor
INE81_RS03955	COG5434	Belongs to the glycosyl hydrolase 28 family
INE81_RS03960	COG4771	TonB-dependent receptor
INE81_RS03965	COG0561	phosphatase activity
INE81_RS03975	COG3250	beta-galactosidase activity
INE81_RS03980	COG5434	Belongs to the glycosyl hydrolase 28 family
INE81_RS03985	COG3292	Two component regulator propeller
INE81_RS03985	COG2205	protein histidine kinase activity
INE81_RS03985	COG0745	RESPONSE REGULATOR receiver
INE81_RS04000	COG4452	Inner membrane protein CreD
INE81_RS04005	COG0582	viral genome integration into host DNA
INE81_RS04045	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE81_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
INE81_RS04060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INE81_RS04065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
INE81_RS04070	COG0012	GTP binding
INE81_RS04075	COG2814	Major facilitator Superfamily
INE81_RS04085	COG0738	Major facilitator superfamily
INE81_RS04095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INE81_RS04105	COG0557	exoribonuclease II activity
INE81_RS04125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE81_RS04130	COG0826	peptidase U32
INE81_RS04160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INE81_RS04165	COG1053	succinate dehydrogenase
INE81_RS04185	COG3409	Peptidoglycan-binding domain 1 protein
INE81_RS04185	COG0793	Belongs to the peptidase S41A family
INE81_RS04190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INE81_RS04240	COG1629	transport
INE81_RS04240	COG4206	TonB-dependent receptor
INE81_RS04305	COG0702	epimerase
INE81_RS04310	COG4771	TonB-dependent receptor
INE81_RS04320	COG4771	TonB-dependent receptor
INE81_RS04365	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
INE81_RS04385	COG0545	Peptidyl-prolyl cis-trans isomerase
INE81_RS04390	COG0545	Peptidyl-prolyl cis-trans isomerase
INE81_RS04395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INE81_RS04405	COG0438	transferase activity, transferring glycosyl groups
INE81_RS04410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INE81_RS04435	COG1216	Glycosyl transferase, family 2
INE81_RS04470	COG0606	chelatase, subunit chli
INE81_RS04485	COG4974	Belongs to the 'phage' integrase family
INE81_RS04505	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INE81_RS04510	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE81_RS04540	COG1629	transport
INE81_RS04540	COG4206	TonB-dependent receptor
INE81_RS04555	COG0745	RESPONSE REGULATOR receiver
INE81_RS04560	COG3437	response regulator, receiver
INE81_RS04560	COG4999	Histidine kinase
INE81_RS04560	COG2205	protein histidine kinase activity
INE81_RS04560	COG3850	Histidine kinase
INE81_RS04580	COG3292	Two component regulator propeller
INE81_RS04580	COG2205	protein histidine kinase activity
INE81_RS04580	COG0745	RESPONSE REGULATOR receiver
INE81_RS04595	COG1629	transport
INE81_RS04630	COG5012	cobalamin binding
INE81_RS04665	COG0318	PFAM AMP-dependent synthetase and ligase
INE81_RS04670	COG1396	sequence-specific DNA binding
INE81_RS04675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INE81_RS04705	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INE81_RS04710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INE81_RS04715	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE81_RS04720	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE81_RS04720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE81_RS04745	COG4206	TonB-dependent receptor
INE81_RS04745	COG1629	transport
INE81_RS04750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INE81_RS04755	COG0339	signal peptide processing
INE81_RS04780	COG0018	arginyl-trna synthetase
INE81_RS04820	COG3118	belongs to the thioredoxin family
INE81_RS04825	COG2816	NAD+ diphosphatase activity
INE81_RS04840	COG5492	domain, Protein
INE81_RS04845	COG0483	inositol monophosphate 1-phosphatase activity
INE81_RS04850	COG1040	competence protein
INE81_RS04885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE81_RS04900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INE81_RS04905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INE81_RS04910	COG0509	glycine decarboxylation via glycine cleavage system
INE81_RS04925	COG0006	proline dipeptidase activity
INE81_RS04930	COG2205	protein histidine kinase activity
INE81_RS04935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INE81_RS04940	COG1283	sodium-dependent phosphate transmembrane transporter activity
INE81_RS04945	COG1773	rubredoxin
INE81_RS04955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INE81_RS04960	COG1011	Hydrolase
INE81_RS04965	COG0196	riboflavin kinase activity
INE81_RS04990	COG3655	Transcriptional regulator
INE81_RS05015	COG2166	iron-sulfur cluster assembly
INE81_RS05020	COG2234	aminopeptidase activity
INE81_RS05025	COG1619	proteins homologs of microcin C7 resistance protein MccF
INE81_RS05030	COG0280	phosphate acetyltransferase
INE81_RS05035	COG3426	butyrate kinase activity
INE81_RS05040	COG2818	Glycosylase
INE81_RS05055	COG4206	TonB-dependent receptor
INE81_RS05055	COG1629	transport
INE81_RS05070	COG1185	polyribonucleotide nucleotidyltransferase activity
INE81_RS05080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INE81_RS05085	COG0537	adenosine 5'-monophosphoramidase activity
INE81_RS05160	COG4804	nuclease activity
INE81_RS05165	COG4974	Belongs to the 'phage' integrase family
INE81_RS05210	COG0463	Glycosyl transferase, family 2
INE81_RS05240	COG2096	Adenosyltransferase
INE81_RS05255	COG0252	asparaginase activity
INE81_RS05260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
INE81_RS05265	COG1027	Aspartate ammonia-lyase
INE81_RS05275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INE81_RS05300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INE81_RS05310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INE81_RS05325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE81_RS05335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
INE81_RS05340	COG0006	proline dipeptidase activity
INE81_RS05345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
INE81_RS05350	COG4974	Belongs to the 'phage' integrase family
INE81_RS05355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
INE81_RS05380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INE81_RS05400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INE81_RS05405	COG0081	regulation of translation
INE81_RS05410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INE81_RS05415	COG0222	ribosome binding
INE81_RS05420	COG0085	RNA polymerase activity
INE81_RS05425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INE81_RS05445	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INE81_RS05450	COG0049	tRNA binding
INE81_RS05455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE81_RS05460	COG0051	transcription antitermination factor activity, RNA binding
INE81_RS05465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INE81_RS05470	COG0088	Forms part of the polypeptide exit tunnel
INE81_RS05475	COG0089	rRNA binding
INE81_RS05480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INE81_RS05485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INE81_RS05495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INE81_RS05500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INE81_RS05505	COG0255	Belongs to the universal ribosomal protein uL29 family
INE81_RS05510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INE81_RS05515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INE81_RS05520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INE81_RS05525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INE81_RS05530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INE81_RS05535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INE81_RS05540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INE81_RS05545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INE81_RS05550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INE81_RS05555	COG1841	ribosomal large subunit assembly
INE81_RS05560	COG0200	Binds to the 23S rRNA
INE81_RS05575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INE81_RS05580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INE81_RS05585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INE81_RS05590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
INE81_RS05595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INE81_RS05600	COG0202	RNA polymerase activity
INE81_RS05605	COG0203	ribosomal protein L17
INE81_RS05620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE81_RS05630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
INE81_RS05640	COG1228	amidohydrolase
INE81_RS05650	COG2986	histidine ammonia-lyase
INE81_RS05665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE81_RS05690	COG1696	Membrane protein involved in D-alanine export
INE81_RS05695	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE81_RS05700	COG1595	DNA-templated transcription, initiation
INE81_RS05710	COG0366	Alpha amylase catalytic
INE81_RS05720	COG1301	dicarboxylic acid transport
INE81_RS05730	COG4948	Mandelate Racemase Muconate Lactonizing
INE81_RS05755	COG1629	transport
INE81_RS05865	COG0564	pseudouridine synthase activity
INE81_RS05880	COG2204	response regulator
INE81_RS05885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INE81_RS05890	COG0612	Peptidase, M16
INE81_RS05895	COG0534	Mate efflux family protein
INE81_RS05900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE81_RS05900	COG2205	protein histidine kinase activity
INE81_RS05920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INE81_RS05925	COG0488	(ABC) transporter
INE81_RS05930	COG3590	peptidase
INE81_RS05935	COG0138	bifunctional purine biosynthesis protein purh
INE81_RS05960	COG0772	Belongs to the SEDS family
INE81_RS05970	COG1774	PSP1 C-terminal conserved region
INE81_RS05975	COG0470	DNA polymerase III
INE81_RS05980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INE81_RS06015	COG4191	Histidine kinase
INE81_RS06030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE81_RS06035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INE81_RS06040	COG1160	GTP binding
INE81_RS06045	COG2197	response regulator
INE81_RS06050	COG1127	ABC transporter
INE81_RS06055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
INE81_RS06065	COG0456	acetyltransferase
INE81_RS06070	COG0724	RNA recognition motif
INE81_RS06075	COG0544	peptidyl-prolyl cis-trans isomerase activity
INE81_RS06080	COG0740	serine-type endopeptidase activity
INE81_RS06085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INE81_RS06090	COG0514	ATP-dependent DNA helicase (RecQ)
INE81_RS06095	COG0517	IMP dehydrogenase activity
INE81_RS06095	COG0516	GMP reductase activity
INE81_RS06100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE81_RS06125	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INE81_RS06145	COG3292	Two component regulator propeller
INE81_RS06145	COG2205	protein histidine kinase activity
INE81_RS06145	COG0745	RESPONSE REGULATOR receiver
INE81_RS06150	COG1082	Xylose isomerase domain protein TIM barrel
INE81_RS06165	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS06175	COG3250	beta-galactosidase activity
INE81_RS06180	COG0383	alpha-mannosidase activity
INE81_RS06185	COG3292	Two component regulator propeller
INE81_RS06185	COG0745	RESPONSE REGULATOR receiver
INE81_RS06185	COG2205	protein histidine kinase activity
INE81_RS06205	COG4771	TonB-dependent receptor
INE81_RS06215	COG3537	Alpha-1,2-mannosidase
INE81_RS06225	COG3250	beta-galactosidase activity
INE81_RS06250	COG0657	acetylesterase activity
INE81_RS06250	COG2755	lipolytic protein G-D-S-L family
INE81_RS06265	COG3015	lipoprotein NlpE involved in copper resistance
INE81_RS06270	COG3022	response to hydroperoxide
INE81_RS06275	COG0110	maltose O-acetyltransferase activity
INE81_RS06305	COG0489	protein tyrosine kinase activity
INE81_RS06305	COG3206	protein involved in exopolysaccharide biosynthesis
INE81_RS06310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
INE81_RS06320	COG1086	Polysaccharide biosynthesis protein
INE81_RS06350	COG4372	Transposase
INE81_RS06355	COG1086	Polysaccharide biosynthesis protein
INE81_RS06375	COG1216	Glycosyl transferase, family 2
INE81_RS06375	COG1442	glycosyl transferase family 8
INE81_RS06385	COG0438	transferase activity, transferring glycosyl groups
INE81_RS06405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
INE81_RS06410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE81_RS06425	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE81_RS06445	COG0592	DNA-directed DNA polymerase activity
INE81_RS06525	COG0602	queuosine metabolic process
INE81_RS06745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INE81_RS06835	COG1187	pseudouridine synthase activity
INE81_RS06840	COG0017	Asparaginyl-tRNA synthetase
INE81_RS06850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INE81_RS06855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INE81_RS06860	COG0052	Belongs to the universal ribosomal protein uS2 family
INE81_RS06865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INE81_RS06880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
INE81_RS06885	COG0179	Fumarylacetoacetate (FAA) hydrolase
INE81_RS06890	COG2957	Belongs to the agmatine deiminase family
INE81_RS06900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INE81_RS06920	COG0482	sulfurtransferase activity
INE81_RS06930	COG1570	exodeoxyribonuclease VII activity
INE81_RS06940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE81_RS06950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INE81_RS06955	COG0489	protein tyrosine kinase activity
INE81_RS06960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE81_RS06975	COG0745	RESPONSE REGULATOR receiver
INE81_RS06975	COG2205	protein histidine kinase activity
INE81_RS06975	COG3292	Two component regulator propeller
INE81_RS06985	COG3458	cephalosporin-C deacetylase activity
INE81_RS07005	COG0702	epimerase
INE81_RS07010	COG1629	transport
INE81_RS07020	COG4124	Belongs to the glycosyl hydrolase 26 family
INE81_RS07025	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE81_RS07030	COG1082	Xylose isomerase domain protein TIM barrel
INE81_RS07035	COG3250	beta-galactosidase activity
INE81_RS07040	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE81_RS07045	COG3119	arylsulfatase activity
INE81_RS07045	COG3408	Glycogen debranching enzyme
INE81_RS07060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE81_RS07075	COG0039	L-malate dehydrogenase activity
INE81_RS07095	COG3275	phosphorelay sensor kinase activity
INE81_RS07100	COG3279	Response regulator of the LytR AlgR family
INE81_RS07115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
INE81_RS07120	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
INE81_RS07130	COG0616	signal peptide processing
INE81_RS07170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INE81_RS07180	COG0811	peptide transport
INE81_RS07200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INE81_RS07205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INE81_RS07210	COG0105	UTP biosynthetic process
INE81_RS07215	COG0739	heme binding
INE81_RS07230	COG0149	triose-phosphate isomerase activity
INE81_RS07240	COG0302	gtp cyclohydrolase
INE81_RS07245	COG0358	DNA primase activity
INE81_RS07260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
INE81_RS07265	COG0436	Aminotransferase
INE81_RS07280	COG0514	ATP-dependent DNA helicase (RecQ)
INE81_RS07285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INE81_RS07285	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INE81_RS07295	COG0009	L-threonylcarbamoyladenylate synthase
INE81_RS07300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE81_RS07310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INE81_RS07325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INE81_RS07335	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INE81_RS07345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE81_RS07350	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
INE81_RS07355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE81_RS07370	COG2431	L-lysine efflux transmembrane transporter activity
INE81_RS07405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INE81_RS07410	COG3292	Two component regulator propeller
INE81_RS07410	COG0745	RESPONSE REGULATOR receiver
INE81_RS07410	COG2205	protein histidine kinase activity
INE81_RS07430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE81_RS07455	COG0360	Binds together with S18 to 16S ribosomal RNA
INE81_RS07460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INE81_RS07465	COG0359	binds to the 23S rRNA
INE81_RS07475	COG1022	Amp-dependent synthetase and ligase
INE81_RS07480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE81_RS07500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INE81_RS07510	COG1640	4-alpha-glucanotransferase
INE81_RS07520	COG0778	Nitroreductase
INE81_RS07525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INE81_RS07535	COG0860	N-Acetylmuramoyl-L-alanine amidase
INE81_RS07545	COG0673	inositol 2-dehydrogenase activity
INE81_RS07550	COG3876	Protein conserved in bacteria
INE81_RS07565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INE81_RS07570	COG2502	aspartate--ammonia ligase
INE81_RS07585	COG2431	L-lysine efflux transmembrane transporter activity
INE81_RS07590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE81_RS07600	COG0166	Belongs to the GPI family
INE81_RS07605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INE81_RS07610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INE81_RS07635	COG2985	domain, Protein
INE81_RS07635	COG0569	domain protein
INE81_RS07640	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE81_RS07645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE81_RS07645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE81_RS07660	COG2885	chlorophyll binding
INE81_RS07710	COG3681	Belongs to the UPF0597 family
INE81_RS07715	COG1047	Peptidyl-prolyl cis-trans
INE81_RS07720	COG0129	dihydroxy-acid dehydratase activity
INE81_RS07725	COG0028	Belongs to the TPP enzyme family
INE81_RS07740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INE81_RS07745	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE81_RS07750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INE81_RS07755	COG0538	isocitrate dehydrogenase activity
INE81_RS07760	COG0372	Belongs to the citrate synthase family
INE81_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
INE81_RS07780	COG0205	6-phosphofructokinase activity
INE81_RS07785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INE81_RS07790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INE81_RS07815	COG0084	hydrolase, TatD family'
INE81_RS07825	COG0811	peptide transport
INE81_RS07855	COG1522	sequence-specific DNA binding
INE81_RS07865	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INE81_RS07880	COG1595	DNA-templated transcription, initiation
INE81_RS07925	COG0488	(ABC) transporter
INE81_RS07930	COG2204	response regulator
INE81_RS07940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INE81_RS07960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INE81_RS07965	COG1088	dTDP-glucose 4,6-dehydratase activity
INE81_RS07970	COG1575	Belongs to the MenA family. Type 1 subfamily
INE81_RS07975	COG1408	metallophosphoesterase
INE81_RS07990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INE81_RS07995	COG0194	GDP metabolic process
INE81_RS08015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INE81_RS08020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INE81_RS08035	COG0750	zinc metalloprotease
INE81_RS08050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE81_RS08060	COG1011	Hydrolase
INE81_RS08070	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
INE81_RS08070	COG1328	CTP reductase activity
INE81_RS08075	COG1272	protein, Hemolysin III
INE81_RS08095	COG1011	Hydrolase
INE81_RS08100	COG0110	maltose O-acetyltransferase activity
INE81_RS08105	COG0673	inositol 2-dehydrogenase activity
INE81_RS08110	COG0632	four-way junction helicase activity
INE81_RS08125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
INE81_RS08130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE81_RS08140	COG0617	tRNA 3'-terminal CCA addition
INE81_RS08140	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INE81_RS08140	COG3620	sequence-specific DNA binding
INE81_RS08155	COG0006	proline dipeptidase activity
INE81_RS08165	COG1505	serine-type exopeptidase activity
INE81_RS08180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INE81_RS08190	COG0280	phosphate acetyltransferase
INE81_RS08190	COG0281	malic enzyme
INE81_RS08205	COG2814	Major facilitator Superfamily
INE81_RS08230	COG0534	Mate efflux family protein
INE81_RS08255	COG3385	transposase activity
INE81_RS08280	COG2873	o-acetylhomoserine
INE81_RS08295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE81_RS08300	COG0511	ligase activity, forming carbon-carbon bonds
INE81_RS08300	COG5016	pyruvate
INE81_RS08305	COG0439	Biotin carboxylase
INE81_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
INE81_RS08365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INE81_RS08370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INE81_RS08375	COG0066	3-isopropylmalate dehydratase activity
INE81_RS08390	COG0671	phosphoesterase, PA-phosphatase related
INE81_RS08435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INE81_RS08450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INE81_RS08460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE81_RS08490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INE81_RS08495	COG0459	protein refolding
INE81_RS08530	COG0784	Response regulator, receiver
INE81_RS08530	COG2205	protein histidine kinase activity
INE81_RS08530	COG5002	protein histidine kinase activity
INE81_RS08535	COG0484	heat shock protein binding
INE81_RS08550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INE81_RS08585	COG3275	phosphorelay sensor kinase activity
INE81_RS08590	COG3279	Response regulator of the LytR AlgR family
INE81_RS08620	COG1752	Esterase of the alpha-beta hydrolase superfamily
INE81_RS08630	COG4771	TonB-dependent receptor
INE81_RS08635	COG0702	epimerase
INE81_RS08660	COG1621	beta-fructofuranosidase activity
INE81_RS08670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INE81_RS08670	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
INE81_RS08690	COG0745	RESPONSE REGULATOR receiver
INE81_RS08690	COG2205	protein histidine kinase activity
INE81_RS08690	COG3292	Two component regulator propeller
INE81_RS08720	COG4176	ABC-type proline glycine betaine transport system permease component
INE81_RS08725	COG2113	Glycine betaine
INE81_RS08745	COG1649	PFAM Uncharacterised BCR, COG1649
INE81_RS08750	COG1966	Carbon starvation protein
INE81_RS08775	COG1649	PFAM Uncharacterised BCR, COG1649
INE81_RS08790	COG2205	protein histidine kinase activity
INE81_RS08790	COG0745	RESPONSE REGULATOR receiver
INE81_RS08790	COG3292	Two component regulator propeller
INE81_RS08795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INE81_RS08795	COG0047	phosphoribosylformylglycinamidine synthase activity
INE81_RS08800	COG1280	lysine exporter protein (LysE YggA)
INE81_RS08815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
INE81_RS08830	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
INE81_RS08845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE81_RS08850	COG1554	hydrolase, family 65, central catalytic
INE81_RS08860	COG1609	Transcriptional regulator
INE81_RS08865	COG1629	transport
INE81_RS08865	COG4206	TonB-dependent receptor
INE81_RS08870	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE81_RS08885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INE81_RS08890	COG0254	rRNA binding
INE81_RS08900	COG0191	fructose-bisphosphate aldolase activity
INE81_RS08910	COG0366	Alpha amylase catalytic
INE81_RS08915	COG0457	Tetratricopeptide repeat
INE81_RS08920	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
INE81_RS08925	COG5016	pyruvate
INE81_RS08925	COG0511	ligase activity, forming carbon-carbon bonds
INE81_RS08935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE81_RS08940	COG0346	lactoylglutathione lyase activity
INE81_RS08955	COG0288	reversible hydration of carbon dioxide
INE81_RS08960	COG0778	Nitroreductase
INE81_RS08980	COG0424	maF-like protein
INE81_RS09000	COG0126	phosphoglycerate kinase activity
INE81_RS09005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INE81_RS09015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INE81_RS09110	COG0297	glycogen (starch) synthase activity
INE81_RS09115	COG1045	serine acetyltransferase
INE81_RS09135	COG1216	Glycosyl transferase, family 2
INE81_RS09135	COG1442	glycosyl transferase family 8
INE81_RS09145	COG0438	transferase activity, transferring glycosyl groups
INE81_RS09190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INE81_RS09195	COG1523	belongs to the glycosyl hydrolase 13 family
INE81_RS09200	COG1119	ATPase activity
INE81_RS09210	COG2205	protein histidine kinase activity
INE81_RS09210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE81_RS09215	COG0588	phosphoglycerate mutase activity
INE81_RS09220	COG1830	Aldolase
INE81_RS09225	COG3119	arylsulfatase activity
INE81_RS09235	COG0668	transmembrane transport
INE81_RS09240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INE81_RS09245	COG3119	arylsulfatase activity
INE81_RS09285	COG1629	transport
INE81_RS09285	COG4206	TonB-dependent receptor
INE81_RS09295	COG3119	arylsulfatase activity
INE81_RS09300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE81_RS09305	COG3250	beta-galactosidase activity
INE81_RS09320	COG3250	beta-galactosidase activity
INE81_RS09330	COG3119	arylsulfatase activity
INE81_RS09345	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE81_RS09380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INE81_RS09485	COG1082	Xylose isomerase domain protein TIM barrel
INE81_RS09515	COG0457	Tetratricopeptide repeat
INE81_RS09520	COG2814	Major facilitator Superfamily
INE81_RS09560	COG3328	transposase activity
INE81_RS09585	COG3385	transposase activity
INE81_RS09660	COG3385	transposase activity
INE81_RS09680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INE81_RS09685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INE81_RS09695	COG2202	Pas domain
INE81_RS09695	COG2205	protein histidine kinase activity
INE81_RS09700	COG2205	protein histidine kinase activity
INE81_RS09700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE81_RS09715	COG0037	tRNA processing
INE81_RS09720	COG1918	ferrous iron import across plasma membrane
INE81_RS09720	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INE81_RS09750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INE81_RS09755	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS09760	COG0517	IMP dehydrogenase activity
INE81_RS09760	COG0516	GMP reductase activity
INE81_RS09780	COG0471	metal ion transport
INE81_RS09780	COG0490	domain, Protein
INE81_RS09795	COG0346	lactoylglutathione lyase activity
INE81_RS09810	COG0259	pyridoxamine-phosphate oxidase activity
INE81_RS09815	COG1741	Belongs to the pirin family
INE81_RS09820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE81_RS09845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
INE81_RS09850	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
INE81_RS09870	COG1629	transport
INE81_RS09870	COG4206	TonB-dependent receptor
INE81_RS09875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
INE81_RS09890	COG1595	DNA-templated transcription, initiation
INE81_RS09915	COG0686	Belongs to the AlaDH PNT family
INE81_RS09920	COG0739	heme binding
INE81_RS09930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE81_RS09950	COG0488	(ABC) transporter
INE81_RS09960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE81_RS09965	COG2207	Transcriptional regulator
INE81_RS09965	COG0662	Cupin 2, conserved barrel domain protein
INE81_RS09970	COG0295	cytidine deaminase activity
INE81_RS09975	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE81_RS10015	COG1181	Belongs to the D-alanine--D-alanine ligase family
INE81_RS10055	COG3385	transposase activity
INE81_RS10085	COG1629	transport
INE81_RS10105	COG1136	(ABC) transporter
INE81_RS10125	COG0577	efflux transmembrane transporter activity
INE81_RS10125	COG1136	(ABC) transporter
INE81_RS10135	COG5002	protein histidine kinase activity
INE81_RS10135	COG0784	Response regulator, receiver
INE81_RS10135	COG2205	protein histidine kinase activity
INE81_RS10145	COG2204	response regulator
INE81_RS10160	COG2985	domain, Protein
INE81_RS10195	COG1979	alcohol dehydrogenase
INE81_RS10215	COG2755	lipolytic protein G-D-S-L family
INE81_RS10220	COG1530	ribonuclease E activity
INE81_RS10235	COG0629	single-stranded DNA binding
INE81_RS10265	COG3507	Belongs to the glycosyl hydrolase 43 family
INE81_RS10265	COG3507	Belongs to the glycosyl hydrolase 43 family
INE81_RS10270	COG3033	Beta-eliminating lyase
INE81_RS10300	COG0745	RESPONSE REGULATOR receiver
INE81_RS10305	COG1408	metallophosphoesterase
INE81_RS10325	COG0488	(ABC) transporter
INE81_RS10345	COG0436	Aminotransferase
INE81_RS10360	COG1215	transferase activity, transferring glycosyl groups
INE81_RS10365	COG0628	permease
INE81_RS10375	COG2205	protein histidine kinase activity
INE81_RS10385	COG2205	protein histidine kinase activity
INE81_RS10385	COG0745	RESPONSE REGULATOR receiver
INE81_RS10385	COG3292	Two component regulator propeller
INE81_RS10385	COG2205	protein histidine kinase activity
INE81_RS10385	COG3292	Two component regulator propeller
INE81_RS10385	COG0745	RESPONSE REGULATOR receiver
INE81_RS10390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
INE81_RS10400	COG4771	TonB-dependent receptor
INE81_RS10405	COG0702	epimerase
INE81_RS10465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
INE81_RS10465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE81_RS10480	COG4753	response regulator
INE81_RS10480	COG2207	Transcriptional regulator
INE81_RS10500	COG4771	TonB-dependent receptor
INE81_RS10605	COG1120	ATPase activity
INE81_RS10610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INE81_RS10640	COG4932	domain protein
INE81_RS10640	COG4886	Leucine-rich repeat (LRR) protein
INE81_RS10685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE81_RS10745	COG1196	nuclear chromosome segregation
INE81_RS10745	COG0739	heme binding
INE81_RS10745	COG0741	lytic transglycosylase activity
INE81_RS10785	COG1192	Involved in chromosome partitioning
INE81_RS10795	COG1475	DNA binding
INE81_RS10930	COG4974	Belongs to the 'phage' integrase family
INE81_RS10985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
INE81_RS11000	COG0667	Aldo Keto reductase
INE81_RS11015	COG1028	Short-chain dehydrogenase reductase Sdr
INE81_RS11025	COG2171	N-acyltransferase activity
INE81_RS11030	COG1979	alcohol dehydrogenase
INE81_RS11050	COG1028	Short-chain dehydrogenase reductase Sdr
INE81_RS11065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE81_RS11080	COG0656	L-ascorbic acid biosynthetic process
INE81_RS11090	COG0656	L-ascorbic acid biosynthetic process
INE81_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
INE81_RS11110	COG0656	L-ascorbic acid biosynthetic process
INE81_RS11120	COG0667	Aldo Keto reductase
INE81_RS11145	COG1609	Transcriptional regulator
INE81_RS11150	COG1028	Short-chain dehydrogenase reductase Sdr
INE81_RS11155	COG1312	Catalyzes the dehydration of D-mannonate
INE81_RS11160	COG0662	Cupin 2, conserved barrel domain protein
INE81_RS11160	COG2207	Transcriptional regulator
INE81_RS11165	COG2140	Oxalate decarboxylase
INE81_RS11185	COG2814	Major facilitator Superfamily
INE81_RS11190	COG4771	TonB-dependent receptor
INE81_RS11195	COG0702	epimerase
INE81_RS11225	COG1484	DNA-dependent DNA replication
INE81_RS11230	COG4584	PFAM Integrase catalytic
INE81_RS11325	COG0438	transferase activity, transferring glycosyl groups
INE81_RS11330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INE81_RS11350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE81_RS11355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE81_RS11385	COG1620	l-lactate permease
INE81_RS11405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE81_RS11410	COG3059	membrane
INE81_RS11415	COG2819	hydrolase of the alpha beta superfamily
INE81_RS11430	COG0110	maltose O-acetyltransferase activity
INE81_RS11440	COG0586	Pfam SNARE associated Golgi protein
INE81_RS11450	COG0306	phosphate transporter
INE81_RS11470	COG0788	formyltetrahydrofolate deformylase activity
INE81_RS11475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INE81_RS11480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INE81_RS11485	COG0107	imidazoleglycerol-phosphate synthase activity
INE81_RS11490	COG0140	phosphoribosyl-ATP diphosphatase activity
INE81_RS11490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INE81_RS11495	COG2884	Cell division ATP-binding protein ftsE
INE81_RS11500	COG0527	aspartate kinase activity
INE81_RS11505	COG0019	diaminopimelate decarboxylase activity
INE81_RS11525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE81_RS11545	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE81_RS11545	COG0321	lipoyl(octanoyl) transferase activity
INE81_RS11580	COG0497	DNA recombination
INE81_RS11605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
INE81_RS11615	COG0167	dihydroorotate dehydrogenase activity
INE81_RS11620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INE81_RS11685	COG1216	Glycosyl transferase, family 2
INE81_RS11685	COG1442	glycosyl transferase family 8
INE81_RS11695	COG0438	transferase activity, transferring glycosyl groups
INE81_RS11720	COG0438	transferase activity, transferring glycosyl groups
INE81_RS11765	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE81_RS11780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE81_RS11800	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
INE81_RS11820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE81_RS11830	COG0573	inorganic phosphate transmembrane transporter activity
INE81_RS11835	COG0581	inorganic phosphate transmembrane transporter activity
INE81_RS11840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INE81_RS11845	COG0704	Plays a role in the regulation of phosphate uptake
INE81_RS11850	COG0307	riboflavin synthase, alpha
INE81_RS11855	COG0778	Nitroreductase
INE81_RS11860	COG1295	ribonuclease BN
INE81_RS11875	COG4948	Mandelate Racemase Muconate Lactonizing
INE81_RS11890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE81_RS11895	COG0363	glucosamine-6-phosphate deaminase activity
INE81_RS11900	COG2365	Tyrosine phosphatase family
INE81_RS11930	COG1032	radical SAM domain protein
INE81_RS11940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INE81_RS11945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INE81_RS11980	COG3328	transposase activity
INE81_RS12025	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
INE81_RS12045	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE81_RS12055	COG0058	SHG alpha-glucan phosphorylase activity
INE81_RS12060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE81_RS12070	COG1176	ABC-type spermidine putrescine transport system, permease component I
INE81_RS12075	COG1177	transmembrane transport
INE81_RS12090	COG0724	RNA recognition motif
INE81_RS12095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE81_RS12100	COG5002	protein histidine kinase activity
INE81_RS12100	COG3850	Histidine kinase
INE81_RS12105	COG0745	RESPONSE REGULATOR receiver
INE81_RS12160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE81_RS12165	COG1917	Cupin 2, conserved barrel domain protein
INE81_RS12165	COG4977	sequence-specific DNA binding
INE81_RS12180	COG0228	four-way junction DNA binding
INE81_RS12200	COG1131	(ABC) transporter
INE81_RS12205	COG0842	Transport permease protein
INE81_RS12210	COG0842	Transport permease protein
INE81_RS12220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INE81_RS12240	COG0556	nucleotide-excision repair
INE81_RS12245	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE81_RS12275	COG1388	LysM domain
INE81_RS12275	COG3942	CHAP domain
INE81_RS12295	COG2197	response regulator
INE81_RS12305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INE81_RS12325	COG1695	Transcriptional regulator
INE81_RS12345	COG0823	Involved in the tonB-independent uptake of proteins
INE81_RS12345	COG1506	peptidase
INE81_RS12350	COG0534	Mate efflux family protein
INE81_RS12360	COG0504	CTP synthase activity
INE81_RS12380	COG4656	Part of a membrane complex involved in electron transport
INE81_RS12385	COG4658	electron transport chain
INE81_RS12390	COG4659	FMN binding
INE81_RS12395	COG4660	Part of a membrane complex involved in electron transport
INE81_RS12400	COG4657	Part of a membrane complex involved in electron transport
INE81_RS12405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INE81_RS12415	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
INE81_RS12420	COG0305	Participates in initiation and elongation during chromosome replication
INE81_RS12425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE81_RS12425	COG0072	phenylalanine-tRNA ligase activity
INE81_RS12430	COG0217	transcriptional regulatory protein
INE81_RS12445	COG1914	H( )-stimulated, divalent metal cation uptake system
INE81_RS12455	COG0708	Exodeoxyribonuclease III
INE81_RS12475	COG0481	GTPase activity
INE81_RS12485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INE81_RS12515	COG0024	Methionine aminopeptidase
INE81_RS12550	COG0564	pseudouridine synthase activity
INE81_RS12555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INE81_RS12560	COG0574	Belongs to the PEP-utilizing enzyme family
INE81_RS12560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INE81_RS12575	COG0352	thiamine-phosphate diphosphorylase activity
INE81_RS12580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
INE81_RS12585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE81_RS12595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
INE81_RS12600	COG2022	thiamine diphosphate biosynthetic process
INE81_RS12605	COG0352	thiamine-phosphate diphosphorylase activity
INE81_RS12615	COG4999	Histidine kinase
INE81_RS12615	COG3850	Histidine kinase
INE81_RS12615	COG3437	response regulator, receiver
INE81_RS12615	COG2205	protein histidine kinase activity
INE81_RS12640	COG2249	NAD(P)H dehydrogenase (quinone) activity
INE81_RS12690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE81_RS12700	COG3275	phosphorelay sensor kinase activity
INE81_RS12715	COG0657	acetylesterase activity
INE81_RS12715	COG2755	lipolytic protein G-D-S-L family
INE81_RS12725	COG3969	phosphoadenosine phosphosulfate
INE81_RS12730	COG1475	DNA binding
INE81_RS12755	COG2205	protein histidine kinase activity
INE81_RS12765	COG0300	oxidoreductase activity
INE81_RS12780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE81_RS12860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INE81_RS12925	COG0175	sulfate reduction
INE81_RS13115	COG0442	prolyl-tRNA aminoacylation
INE81_RS13120	COG0745	RESPONSE REGULATOR receiver
INE81_RS13125	COG0642	Histidine kinase
INE81_RS13170	COG1733	regulation of RNA biosynthetic process
INE81_RS13185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INE81_RS13190	COG1546	Belongs to the CinA family
INE81_RS13190	COG1058	Belongs to the CinA family
INE81_RS13195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INE81_RS13200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INE81_RS13210	COG0552	protein localization to endoplasmic reticulum
INE81_RS13215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE81_RS13230	COG0714	Associated with various cellular activities
INE81_RS13245	COG2304	oxidoreductase activity
INE81_RS13290	COG0542	response to heat
INE81_RS13295	COG0326	Molecular chaperone. Has ATPase activity
INE81_RS13325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE81_RS13330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INE81_RS13335	COG0336	Belongs to the RNA methyltransferase TrmD family
INE81_RS13340	COG0167	dihydroorotate dehydrogenase activity
INE81_RS13345	COG0543	2 iron, 2 sulfur cluster binding
INE81_RS13360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE81_RS13380	COG1538	Outer membrane efflux protein
INE81_RS13390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INE81_RS13435	COG1132	(ABC) transporter
INE81_RS13455	COG2957	Belongs to the agmatine deiminase family
INE81_RS13470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INE81_RS13475	COG1597	lipid kinase activity
INE81_RS13480	COG0156	8-amino-7-oxononanoate synthase activity
INE81_RS13505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
INE81_RS13510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
INE81_RS13515	COG0343	queuine tRNA-ribosyltransferase activity
INE81_RS13530	COG0560	Phosphoserine phosphatase
INE81_RS13530	COG3830	Belongs to the UPF0237 family
INE81_RS13535	COG0513	Belongs to the DEAD box helicase family
INE81_RS13560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE81_RS13580	COG0438	transferase activity, transferring glycosyl groups
INE81_RS13620	COG0010	Belongs to the arginase family
INE81_RS13625	COG0058	SHG alpha-glucan phosphorylase activity
INE81_RS13630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE81_RS13630	COG4651	solute:proton antiporter activity
INE81_RS13635	COG0205	6-phosphofructokinase activity
INE81_RS13650	COG0588	phosphoglycerate mutase activity
INE81_RS13655	COG1830	Aldolase
INE81_RS13665	COG2095	MarC family integral membrane protein
INE81_RS13680	COG0655	NAD(P)H dehydrogenase (quinone) activity
INE81_RS13690	COG0667	Aldo Keto reductase
INE81_RS13705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE81_RS13710	COG4771	TonB-dependent receptor
INE81_RS13720	COG2706	6-phosphogluconolactonase activity
INE81_RS13725	COG2207	Transcriptional regulator
INE81_RS13770	COG0673	inositol 2-dehydrogenase activity
INE81_RS13785	COG1629	transport
INE81_RS13785	COG4206	TonB-dependent receptor
INE81_RS13820	COG4974	Belongs to the 'phage' integrase family
INE81_RS13835	COG1216	Glycosyl transferase, family 2
INE81_RS13880	COG0246	Mannitol dehydrogenase
INE81_RS13885	COG1609	Transcriptional regulator
INE81_RS13890	COG1904	glucuronate isomerase
INE81_RS13905	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE81_RS13915	COG2076	Multidrug Resistance protein
INE81_RS13940	COG1690	Belongs to the RtcB family
INE81_RS13955	COG1252	NADH dehydrogenase
INE81_RS13990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE81_RS14005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INE81_RS14015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INE81_RS14030	COG0724	RNA recognition motif
INE81_RS14035	COG0450	alkyl hydroperoxide reductase
INE81_RS14040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE81_RS14040	COG3153	acetyltransferase
INE81_RS14085	COG1733	regulation of RNA biosynthetic process
INE81_RS14105	COG0351	phosphomethylpyrimidine kinase
INE81_RS14175	COG0358	DNA primase activity
INE81_RS14300	COG0784	Response regulator, receiver
INE81_RS14300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE81_RS14300	COG2198	Histidine kinase
INE81_RS14300	COG2205	protein histidine kinase activity
INE81_RS14320	COG0551	DNA topoisomerase type I activity
INE81_RS14320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE81_RS14355	COG4974	Belongs to the 'phage' integrase family
INE81_RS14360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INE81_RS14370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE81_RS14380	COG0671	phosphoesterase, PA-phosphatase related
INE81_RS14395	COG2223	nitrite transmembrane transporter activity
INE81_RS14400	COG2949	membrane
INE81_RS14425	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
INE81_RS14430	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
INE81_RS14430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
INE81_RS14440	COG0673	inositol 2-dehydrogenase activity
INE81_RS14450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INE81_RS14455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE81_RS14470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INE81_RS14495	COG2205	protein histidine kinase activity
INE81_RS14500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INE81_RS14515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
INE81_RS14520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INE81_RS14525	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INE81_RS14535	COG0540	Belongs to the ATCase OTCase family
INE81_RS14540	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
INE81_RS14555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INE81_RS14560	COG2759	Belongs to the formate--tetrahydrofolate ligase family
INE81_RS14570	COG1091	dTDP-4-dehydrorhamnose reductase activity
INE81_RS14580	COG1924	4 iron, 4 sulfur cluster binding
INE81_RS14585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INE81_RS14590	COG4977	sequence-specific DNA binding
INE81_RS14595	COG4771	TonB-dependent receptor
INE81_RS14610	COG1678	Uncharacterized ACR, COG1678
INE81_RS14630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INE81_RS14665	COG3250	beta-galactosidase activity
INE81_RS14680	COG0321	lipoyl(octanoyl) transferase activity
INE81_RS14685	COG2217	Heavy metal translocating P-type atpase
INE81_RS14705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INE81_RS14725	COG0357	Ribosomal RNA small subunit methyltransferase G
INE81_RS14730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INE81_RS14735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE81_RS14735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE81_RS14740	COG0778	Nitroreductase
INE81_RS14760	COG1739	Uncharacterized protein family UPF0029
INE81_RS14775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE81_RS14780	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INE81_RS14790	COG2871	sodium ion transport
INE81_RS14805	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE81_RS14810	COG1805	sodium ion transport
INE81_RS14815	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE81_RS14860	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE81_RS14910	COG2244	polysaccharide biosynthetic process
INE81_RS14955	COG1629	transport
INE81_RS14960	COG0488	(ABC) transporter
INE81_RS14980	COG3437	response regulator, receiver
INE81_RS14980	COG3850	Histidine kinase
INE81_RS14980	COG4999	Histidine kinase
INE81_RS14980	COG2205	protein histidine kinase activity
INE81_RS15000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INE81_RS15015	COG1595	DNA-templated transcription, initiation
INE81_RS15020	COG1704	LemA family
INE81_RS15025	COG0501	Belongs to the peptidase M48B family
INE81_RS15035	COG0612	Peptidase, M16
INE81_RS15065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INE81_RS15075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE81_RS15100	COG1136	(ABC) transporter
INE81_RS15100	COG0577	efflux transmembrane transporter activity
INE81_RS15130	COG1151	hydroxylamine reductase activity
INE81_RS15135	COG3263	regulation of cellular component size
INE81_RS15145	COG0318	PFAM AMP-dependent synthetase and ligase
INE81_RS15175	COG0653	protein targeting
INE81_RS15340	COG0501	Belongs to the peptidase M48B family
INE81_RS15380	COG1073	alpha beta
INE81_RS15395	COG4771	TonB-dependent receptor
INE81_RS15405	COG1074	ATP-dependent DNA helicase activity
INE81_RS15415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE81_RS15420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INE81_RS15425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INE81_RS15430	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE81_RS15435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INE81_RS15440	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE81_RS15445	COG0356	it plays a direct role in the translocation of protons across the membrane
INE81_RS15455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
INE81_RS15460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INE81_RS15465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
INE81_RS15475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INE81_RS15490	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
INE81_RS15500	COG0534	Mate efflux family protein
INE81_RS15515	COG1136	(ABC) transporter
INE81_RS15520	COG1136	(ABC) transporter
INE81_RS15520	COG0577	efflux transmembrane transporter activity
INE81_RS15530	COG3279	Response regulator of the LytR AlgR family
INE81_RS15550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INE81_RS15555	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INE81_RS15560	COG1301	dicarboxylic acid transport
INE81_RS15580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE81_RS15590	COG1216	Glycosyl transferase, family 2
INE81_RS15590	COG1442	glycosyl transferase family 8
INE81_RS15690	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INE81_RS15695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE81_RS15705	COG3119	arylsulfatase activity
INE81_RS15715	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
INE81_RS15725	COG0534	Mate efflux family protein
INE81_RS15750	COG1917	Cupin 2, conserved barrel domain protein
INE81_RS15750	COG4977	sequence-specific DNA binding
INE81_RS15755	COG4771	TonB-dependent receptor
INE81_RS15770	COG0737	Belongs to the 5'-nucleotidase family
INE81_RS15775	COG2205	protein histidine kinase activity
INE81_RS15775	COG2202	Pas domain
INE81_RS15780	COG2183	response to ionizing radiation
INE81_RS15795	COG2197	response regulator
INE81_RS15805	COG0138	bifunctional purine biosynthesis protein purh
INE81_RS15810	COG0716	FMN binding
INE81_RS15820	COG1730	sister chromatid segregation
INE81_RS15845	COG0251	oxidation-reduction process
INE81_RS15850	COG1333	cytochrome c biogenesis protein
INE81_RS15850	COG1333	cytochrome c biogenesis protein
INE81_RS15850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE81_RS15850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE81_RS15905	COG4771	TonB-dependent receptor
INE81_RS15930	COG1132	(ABC) transporter
INE81_RS15945	COG2985	domain, Protein
INE81_RS15945	COG0490	domain, Protein
INE81_RS15980	COG1609	Transcriptional regulator
INE81_RS15985	COG2721	sulfolactate sulfo-lyase activity
INE81_RS16000	COG0784	Response regulator, receiver
INE81_RS16000	COG2198	Histidine kinase
INE81_RS16000	COG2205	protein histidine kinase activity
INE81_RS16005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE81_RS16010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE81_RS16025	COG0438	transferase activity, transferring glycosyl groups
INE81_RS16030	COG0110	maltose O-acetyltransferase activity
INE81_RS16035	COG1215	transferase activity, transferring glycosyl groups
INE81_RS16070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INE81_RS16075	COG0489	protein tyrosine kinase activity
INE81_RS16075	COG3206	protein involved in exopolysaccharide biosynthesis
INE81_RS16075	COG0489	protein tyrosine kinase activity
INE81_RS16075	COG3206	protein involved in exopolysaccharide biosynthesis
INE81_RS16095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE81_RS16100	COG0505	Belongs to the CarA family
INE81_RS16110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INE81_RS16115	COG0067	glutamate synthase
INE81_RS16115	COG0069	glutamate synthase activity
INE81_RS16115	COG0070	glutamate synthase
INE81_RS16125	COG0367	asparagine synthase
INE81_RS16155	COG0347	Belongs to the P(II) protein family
INE81_RS16160	COG0004	ammonium transporteR
INE81_RS16175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INE81_RS16185	COG1979	alcohol dehydrogenase
INE81_RS16190	COG0133	tryptophan synthase activity
INE81_RS16195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INE81_RS16200	COG0512	Glutamine amidotransferase of anthranilate synthase
INE81_RS16200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INE81_RS16210	COG0134	indole-3-glycerol-phosphate synthase activity
INE81_RS16215	COG0135	phosphoribosylanthranilate isomerase activity
INE81_RS16220	COG0159	tryptophan synthase activity
INE81_RS16225	COG0252	asparaginase activity
INE81_RS16235	COG0745	RESPONSE REGULATOR receiver
INE81_RS16235	COG2205	protein histidine kinase activity
INE81_RS16235	COG3292	Two component regulator propeller
INE81_RS16240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE81_RS16265	COG1595	DNA-templated transcription, initiation
INE81_RS16280	COG0488	(ABC) transporter
INE81_RS16285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INE81_RS16290	COG0484	heat shock protein binding
INE81_RS16295	COG4413	Urea transporter
INE81_RS16315	COG0702	epimerase
INE81_RS16320	COG4771	TonB-dependent receptor
INE81_RS16335	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
INE81_RS16345	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE81_RS16355	COG2271	Major facilitator Superfamily
INE81_RS16365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE81_RS16370	COG1940	carbohydrate kinase activity
INE81_RS16560	COG4680	protein conserved in bacteria
INE81_RS16655	COG0175	sulfate reduction
INE81_RS16740	COG1061	Type III restriction enzyme res subunit
INE81_RS16765	COG0085	RNA polymerase activity
INE81_RS16850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INE81_RS16860	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
INE81_RS16860	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE81_RS16860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE81_RS16860	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE81_RS16865	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE81_RS16870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE81_RS16880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INE81_RS16885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INE81_RS16890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INE81_RS16895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INE81_RS16910	COG0242	peptide deformylase activity
INE81_RS16915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INE81_RS16940	COG4974	Belongs to the 'phage' integrase family
INE81_RS16980	COG0175	sulfate reduction
INE81_RS16985	COG0529	Catalyzes the synthesis of activated sulfate
INE81_RS16990	COG0471	metal ion transport
INE81_RS16990	COG3273	potassium ion transport
INE81_RS16995	COG1218	3'(2'),5'-bisphosphate nucleotidase
INE81_RS17010	COG4221	oxidoreductase activity
INE81_RS17015	COG0513	Belongs to the DEAD box helicase family
INE81_RS17040	COG4585	Histidine kinase
INE81_RS17055	COG1482	cell wall glycoprotein biosynthetic process
INE81_RS17070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INE81_RS17095	COG2160	L-arabinose isomerase activity
INE81_RS17105	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
INE81_RS17110	COG0698	ribose 5-phosphate isomerase
INE81_RS17160	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE81_RS17165	COG3940	Belongs to the glycosyl hydrolase 43 family
INE81_RS17170	COG0673	inositol 2-dehydrogenase activity
INE81_RS17180	COG1595	DNA-templated transcription, initiation
INE81_RS17200	COG0590	tRNA wobble adenosine to inosine editing
INE81_RS17215	COG2264	protein methyltransferase activity
INE81_RS17245	COG1752	Esterase of the alpha-beta hydrolase superfamily
INE81_RS17250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INE81_RS17255	COG0463	Glycosyl transferase, family 2
INE81_RS17265	COG1410	methionine synthase
INE81_RS17265	COG0646	methionine synthase
INE81_RS17305	COG0420	3'-5' exonuclease activity
INE81_RS17310	COG2205	protein histidine kinase activity
INE81_RS17345	COG0641	radical SAM
INE81_RS17350	COG3591	Belongs to the peptidase S1B family
INE81_RS17355	COG3591	Belongs to the peptidase S1B family
INE81_RS17375	COG3118	belongs to the thioredoxin family
INE81_RS17390	COG1773	rubredoxin
INE81_RS17390	COG1592	Rubrerythrin
INE81_RS17395	COG0735	belongs to the Fur family
INE81_RS17400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INE81_RS17400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE81_RS17405	COG0131	Imidazoleglycerol-phosphate dehydratase
INE81_RS17410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE81_RS17415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INE81_RS17420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INE81_RS17450	COG4771	TonB-dependent receptor
INE81_RS17470	COG1404	Belongs to the peptidase S8 family
INE81_RS17475	COG1741	Belongs to the pirin family
INE81_RS17480	COG4232	protein-disulfide reductase activity
INE81_RS17490	COG0572	uridine kinase
INE81_RS17520	COG0778	Nitroreductase
INE81_RS17525	COG0646	methionine synthase
INE81_RS17525	COG1410	methionine synthase
INE81_RS17530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INE81_RS17585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INE81_RS17630	COG2204	response regulator
INE81_RS17635	COG0784	Response regulator, receiver
INE81_RS17635	COG2205	protein histidine kinase activity
INE81_RS17650	COG0667	Aldo Keto reductase
INE81_RS17660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INE81_RS17665	COG2207	Transcriptional regulator
INE81_RS17690	COG4974	Belongs to the 'phage' integrase family
INE81_RS17720	COG2003	Belongs to the UPF0758 family
INE81_RS17755	COG2373	Large extracellular alpha-helical protein
INE81_RS17760	COG4953	penicillin-binding protein 1C
INE81_RS17765	COG2814	Major facilitator Superfamily
INE81_RS17790	COG2197	response regulator
INE81_RS17795	COG0482	sulfurtransferase activity
INE81_RS17825	COG1253	flavin adenine dinucleotide binding
INE81_RS17845	COG1629	transport
INE81_RS17845	COG4206	TonB-dependent receptor
INE81_RS17875	COG1929	Belongs to the glycerate kinase type-1 family
INE81_RS17880	COG2610	gluconate transmembrane transporter activity
INE81_RS17905	COG1309	transcriptional regulator
INE81_RS17910	COG4974	Belongs to the 'phage' integrase family
INE81_RS17915	COG0517	IMP dehydrogenase activity
INE81_RS17990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE81_RS17990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE81_RS17995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE81_RS17995	COG0551	DNA topoisomerase type I activity
INE81_RS18150	COG4974	Belongs to the 'phage' integrase family
INE81_RS18160	COG4804	nuclease activity
INE81_RS18205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INE81_RS18230	COG0783	Belongs to the Dps family
INE81_RS18235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE81_RS18240	COG3537	Alpha-1,2-mannosidase
INE81_RS18245	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE81_RS18260	COG3250	beta-galactosidase activity
INE81_RS18265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE81_RS18285	COG4948	Mandelate Racemase Muconate Lactonizing
INE81_RS18290	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
INE81_RS18295	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INE81_RS18300	COG1169	isochorismate synthase
INE81_RS18305	COG0561	phosphatase activity
INE81_RS18310	COG3537	Alpha-1,2-mannosidase
INE81_RS18355	COG0702	epimerase
INE81_RS18360	COG1629	transport
INE81_RS18360	COG4206	TonB-dependent receptor
INE81_RS18390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE81_RS18390	COG2755	lipolytic protein G-D-S-L family
INE81_RS18400	COG1063	alcohol dehydrogenase
INE81_RS18690	COG4974	Belongs to the 'phage' integrase family
INE81_RS18700	COG1193	negative regulation of DNA recombination
INE81_RS18705	COG0598	Magnesium transport protein CorA
INE81_RS18710	COG1760	l-serine dehydratase
INE81_RS18750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE81_RS18755	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
INE81_RS18760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
INE81_RS18805	COG0514	ATP-dependent DNA helicase (RecQ)
INE81_RS18855	COG0629	single-stranded DNA binding
INE81_RS18860	COG1192	Involved in chromosome partitioning
INE81_RS18915	COG3118	belongs to the thioredoxin family
INE81_RS18970	COG1373	ATPase (AAA superfamily
INE81_RS19000	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE81_RS19005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE81_RS19065	COG0739	heme binding
INE81_RS19085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INE81_RS19120	COG0500	methyltransferase
INE81_RS19135	COG0456	acetyltransferase
INE81_RS19135	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
INE81_RS19140	COG0488	(ABC) transporter
INE81_RS19170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INE81_RS19180	COG1538	Outer membrane efflux protein
INE81_RS19195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE81_RS19380	COG0443	Heat shock 70 kDa protein
INE81_RS19405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
INE81_RS19415	COG1595	DNA-templated transcription, initiation
INE81_RS19430	COG2855	membrane
INE81_RS19435	COG0583	DNA-binding transcription factor activity
INE81_RS19445	COG0542	response to heat
INE81_RS19460	COG0237	dephospho-CoA kinase activity
INE81_RS19470	COG1862	Preprotein translocase
INE81_RS19475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INE81_RS19485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INE81_RS19490	COG0193	aminoacyl-tRNA hydrolase activity
INE81_RS19495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INE81_RS19505	COG4651	solute:proton antiporter activity
INE81_RS19505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE81_RS19510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
INE81_RS19515	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE81_RS19520	COG5002	protein histidine kinase activity
INE81_RS19525	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
INE81_RS19530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INE81_RS19535	COG1082	Xylose isomerase domain protein TIM barrel
INE81_RS19545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INE81_RS19555	COG0148	phosphopyruvate hydratase activity
INE81_RS19580	COG0463	Glycosyl transferase, family 2
INE81_RS19595	COG1971	Probably functions as a manganese efflux pump
INE81_RS19600	COG1477	protein flavinylation
INE81_RS19610	COG0037	tRNA processing
INE81_RS19625	COG4864	UPF0365 protein
INE81_RS19650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INE81_RS19660	COG4974	Belongs to the 'phage' integrase family
INE81_RS19685	COG0582	viral genome integration into host DNA
INE81_RS19690	COG0732	type I restriction modification DNA specificity domain
INE81_RS19710	COG3645	SOS response
INE81_RS19720	COG3586	endonuclease activity
INE81_RS19725	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
INE81_RS19740	COG3385	transposase activity
INE81_RS19795	COG1538	Outer membrane efflux protein
INE81_RS19805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE81_RS19810	COG3275	phosphorelay sensor kinase activity
INE81_RS19820	COG3387	PFAM Glycoside hydrolase 15-related
INE81_RS19825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
INE81_RS19830	COG0693	protein deglycase activity
INE81_RS19865	COG0564	pseudouridine synthase activity
INE81_RS19870	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
INE81_RS19885	COG0545	Peptidyl-prolyl cis-trans isomerase
INE81_RS19905	COG1090	epimerase
INE81_RS19915	COG0741	lytic transglycosylase activity
INE81_RS19915	COG1388	LysM domain
INE81_RS19920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INE81_RS19970	COG1509	lysine 2,3-aminomutase activity
INE81_RS19980	COG4771	TonB-dependent receptor
INE81_RS19990	COG1393	Belongs to the ArsC family
INE81_RS20000	COG4771	TonB-dependent receptor
INE81_RS20010	COG2304	oxidoreductase activity
INE81_RS20015	COG0351	phosphomethylpyrimidine kinase
INE81_RS20025	COG1139	Iron-sulfur cluster binding protein
INE81_RS20030	COG0247	lactate metabolic process
INE81_RS20035	COG0602	queuosine metabolic process
INE81_RS20045	COG2832	Protein of unknown function (DUF454)
INE81_RS20050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE81_RS20085	COG1418	mRNA catabolic process
INE81_RS20090	COG3142	Participates in the control of copper homeostasis
INE81_RS20100	COG1288	antiporter activity
INE81_RS20135	COG0745	RESPONSE REGULATOR receiver
INE81_RS20135	COG2205	protein histidine kinase activity
INE81_RS20135	COG3292	Two component regulator propeller
INE81_RS20155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INE81_RS20165	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS20170	COG2706	6-phosphogluconolactonase activity
INE81_RS20180	COG1496	oxidoreductase activity
INE81_RS20185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE81_RS20195	COG0563	adenylate kinase activity
INE81_RS20200	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INE81_RS20210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
INE81_RS20210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INE81_RS20255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
INE81_RS20270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE81_RS20275	COG1253	flavin adenine dinucleotide binding
INE81_RS20295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
INE81_RS20315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE81_RS20330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE81_RS20345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE81_RS20375	COG0438	transferase activity, transferring glycosyl groups
INE81_RS20405	COG0438	transferase activity, transferring glycosyl groups
INE81_RS20415	COG1144	Oxidoreductase
INE81_RS20420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INE81_RS20425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
INE81_RS20435	COG3206	protein involved in exopolysaccharide biosynthesis
INE81_RS20435	COG0489	protein tyrosine kinase activity
INE81_RS20435	COG0489	protein tyrosine kinase activity
INE81_RS20435	COG3206	protein involved in exopolysaccharide biosynthesis
INE81_RS20480	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
INE81_RS20500	COG0525	valine-tRNA ligase activity
INE81_RS20520	COG3956	TIGRFAM MazG family protein
INE81_RS20535	COG1595	DNA-templated transcription, initiation
INE81_RS20540	COG2989	Protein conserved in bacteria
INE81_RS20550	COG1234	tRNA 3'-trailer cleavage
INE81_RS20580	COG4206	TonB-dependent receptor
INE81_RS20580	COG1629	transport
INE81_RS20610	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE81_RS20615	COG0492	ferredoxin-NADP+ reductase activity
INE81_RS20625	COG1674	ftsk spoiiie
INE81_RS20640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE81_RS20645	COG2211	Major facilitator Superfamily
INE81_RS20665	COG1136	(ABC) transporter
INE81_RS20675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE81_RS20680	COG1597	lipid kinase activity
INE81_RS20685	COG2877	3-deoxy-8-phosphooctulonate synthase activity
INE81_RS20690	COG0612	Peptidase, M16
INE81_RS20705	COG0791	NLP P60 protein
INE81_RS20715	COG0546	phosphoglycolate phosphatase activity
INE81_RS20720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INE81_RS20725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INE81_RS20730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INE81_RS20735	COG0543	2 iron, 2 sulfur cluster binding
INE81_RS20740	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INE81_RS20745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INE81_RS20750	COG0297	glycogen (starch) synthase activity
INE81_RS20780	COG0745	RESPONSE REGULATOR receiver
INE81_RS20780	COG2205	protein histidine kinase activity
INE81_RS20780	COG3292	Two component regulator propeller
INE81_RS20780	COG2205	protein histidine kinase activity
INE81_RS20780	COG3292	Two component regulator propeller
INE81_RS20780	COG0745	RESPONSE REGULATOR receiver
INE81_RS20790	COG2755	lipolytic protein G-D-S-L family
INE81_RS20805	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS20820	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS20830	COG0561	phosphatase activity
INE81_RS20835	COG4771	TonB-dependent receptor
INE81_RS20845	COG3537	Alpha-1,2-mannosidase
INE81_RS20870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INE81_RS20870	COG0519	Catalyzes the synthesis of GMP from XMP
INE81_RS20875	COG1970	mechanosensitive ion channel activity
INE81_RS20885	COG0339	signal peptide processing
INE81_RS20895	COG2131	deaminase
INE81_RS20900	COG0793	Belongs to the peptidase S41A family
INE81_RS20905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INE81_RS20925	COG4206	TonB-dependent receptor
INE81_RS20925	COG1629	transport
INE81_RS20950	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE81_RS20985	COG3250	beta-galactosidase activity
INE81_RS21005	COG0101	tRNA pseudouridine synthase activity
INE81_RS21025	COG2268	Band 7 protein
INE81_RS21035	COG1702	phosphate starvation-inducible protein PhoH
INE81_RS21040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INE81_RS21045	COG2226	methyltransferase
INE81_RS21050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INE81_RS21065	COG1704	LemA family
INE81_RS21070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INE81_RS21075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INE81_RS21085	COG1078	dGTPase activity
INE81_RS21090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE81_RS21095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
INE81_RS21095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INE81_RS21100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE81_RS21110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE81_RS21115	COG4585	Histidine kinase
INE81_RS21120	COG4206	TonB-dependent receptor
INE81_RS21120	COG1629	transport
INE81_RS21135	COG1073	alpha beta
INE81_RS21140	COG2205	protein histidine kinase activity
INE81_RS21140	COG5002	protein histidine kinase activity
INE81_RS21140	COG0784	Response regulator, receiver
INE81_RS21145	COG2873	o-acetylhomoserine
INE81_RS21150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE81_RS21155	COG0561	phosphatase activity
INE81_RS21160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE81_RS21170	COG0009	L-threonylcarbamoyladenylate synthase
INE81_RS21175	COG0363	glucosamine-6-phosphate deaminase activity
INE81_RS21185	COG1242	4 iron, 4 sulfur cluster binding
INE81_RS21190	COG3279	Response regulator of the LytR AlgR family
INE81_RS21205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INE81_RS21225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
INE81_RS21250	COG0546	phosphoglycolate phosphatase activity
INE81_RS21255	COG2755	lipolytic protein G-D-S-L family
INE81_RS21255	COG0657	acetylesterase activity
INE81_RS21260	COG3458	cephalosporin-C deacetylase activity
INE81_RS21265	COG4206	TonB-dependent receptor
INE81_RS21265	COG1629	transport
INE81_RS21285	COG0326	Molecular chaperone. Has ATPase activity
INE81_RS21300	COG0745	RESPONSE REGULATOR receiver
INE81_RS21300	COG3292	Two component regulator propeller
INE81_RS21300	COG2205	protein histidine kinase activity
INE81_RS21305	COG1472	Belongs to the glycosyl hydrolase 3 family
INE81_RS21335	COG4677	pectinesterase activity
INE81_RS21355	COG4771	TonB-dependent receptor
INE81_RS21360	COG1063	alcohol dehydrogenase
INE81_RS21390	COG3408	Glycogen debranching enzyme
INE81_RS21400	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE81_RS21410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
INE81_RS21425	COG5012	cobalamin binding
INE81_RS21430	COG1501	Belongs to the glycosyl hydrolase 31 family
INE81_RS21475	COG3408	Glycogen debranching enzyme
INE81_RS21520	COG4677	pectinesterase activity
INE81_RS21525	COG0702	epimerase
INE81_RS21530	COG1629	transport
INE81_RS21530	COG4206	TonB-dependent receptor
INE81_RS21555	COG2205	protein histidine kinase activity
INE81_RS21555	COG3292	Two component regulator propeller
INE81_RS21555	COG0745	RESPONSE REGULATOR receiver
INE81_RS21560	COG3250	beta-galactosidase activity
INE81_RS21585	COG3250	beta-galactosidase activity
INE81_RS21590	COG3250	beta-galactosidase activity
INE81_RS21605	COG3292	Two component regulator propeller
INE81_RS21605	COG0745	RESPONSE REGULATOR receiver
INE81_RS21605	COG2205	protein histidine kinase activity
INE81_RS21610	COG1073	alpha beta
INE81_RS21615	COG2755	lipolytic protein G-D-S-L family
INE81_RS21620	COG1917	Cupin 2, conserved barrel domain protein
INE81_RS21630	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE81_RS21635	COG2271	Major facilitator Superfamily
INE81_RS21645	COG4977	sequence-specific DNA binding
INE81_RS21645	COG1917	Cupin 2, conserved barrel domain protein
INE81_RS21655	COG0805	protein transport
INE81_RS21660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INE81_RS21665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INE81_RS21675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INE81_RS21680	COG0569	domain protein
INE81_RS21685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE81_RS21695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE81_RS21700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE81_RS21705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE81_RS21705	COG0649	NAD binding
INE81_RS21710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INE81_RS21720	COG0839	Belongs to the complex I subunit 6 family
INE81_RS21725	COG0713	ATP synthesis coupled electron transport
INE81_RS21730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INE81_RS21735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE81_RS21760	COG2942	2-epimerase
INE81_RS21765	COG2211	Major facilitator Superfamily
INE81_RS21770	COG0667	Aldo Keto reductase
INE81_RS21775	COG2207	Transcriptional regulator
INE81_RS21775	COG0662	Cupin 2, conserved barrel domain protein
INE81_RS21780	COG0668	transmembrane transport
INE81_RS21840	COG3275	phosphorelay sensor kinase activity
INE81_RS21845	COG3279	Response regulator of the LytR AlgR family
INE81_RS21865	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE81_RS21875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INE81_RS21880	COG2239	Acts as a magnesium transporter
INE81_RS21895	COG0799	negative regulation of ribosome biogenesis
INE81_RS21900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INE81_RS21905	COG4589	Belongs to the CDS family
INE81_RS21915	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE81_RS21920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
INE81_RS21925	COG1192	Involved in chromosome partitioning
INE81_RS21930	COG1475	DNA binding
INE81_RS21945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INE81_RS21955	COG0739	heme binding
INE81_RS21980	COG3537	Alpha-1,2-mannosidase
INE81_RS22000	COG1082	Xylose isomerase domain protein TIM barrel
INE81_RS22020	COG0742	ribosomal rna small subunit methyltransferase
INE81_RS22025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INE81_RS22040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INE81_RS22065	COG4771	TonB-dependent receptor
INE81_RS22075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INE81_RS22085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INE81_RS22095	COG0745	RESPONSE REGULATOR receiver
INE81_RS22100	COG0802	atpase or kinase
INE81_RS22115	COG0714	Associated with various cellular activities
INE81_RS22160	COG0688	phosphatidylethanolamine metabolic process
INE81_RS22165	COG1183	phosphatidylcholine synthase activity
INE81_RS22185	COG0792	nuclease activity
INE81_RS22205	COG0534	Mate efflux family protein
INE81_RS22215	COG0528	UMP kinase activity
INE81_RS22220	COG0233	cytoplasmic translational termination
INE81_RS22225	COG1162	GTPase activity
INE81_RS22230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE81_RS22235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE81_RS22275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INE81_RS22275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INE81_RS22285	COG3250	beta-galactosidase activity
INE81_RS22305	COG4771	TonB-dependent receptor
INE81_RS22325	COG2205	protein histidine kinase activity
INE81_RS22325	COG0745	RESPONSE REGULATOR receiver
INE81_RS22325	COG2205	protein histidine kinase activity
INE81_RS22325	COG3292	Two component regulator propeller
INE81_RS22325	COG0745	RESPONSE REGULATOR receiver
INE81_RS22325	COG3292	Two component regulator propeller
INE81_RS22335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INE81_RS22350	COG4771	TonB-dependent receptor
INE81_RS22380	COG4771	TonB-dependent receptor
INE81_RS22385	COG4974	Belongs to the 'phage' integrase family