locus-tag	class	description
H1A11_RS00025	COG1629	transport
H1A11_RS00025	COG4206	TonB-dependent receptor
H1A11_RS00040	COG1373	ATPase (AAA superfamily
H1A11_RS00045	COG4206	TonB-dependent receptor
H1A11_RS00045	COG1629	transport
H1A11_RS00055	COG2095	MarC family integral membrane protein
H1A11_RS00070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H1A11_RS00080	COG1435	thymidine kinase activity
H1A11_RS00085	COG0628	permease
H1A11_RS00145	COG4206	TonB-dependent receptor
H1A11_RS00145	COG1629	transport
H1A11_RS00150	COG4974	Belongs to the 'phage' integrase family
H1A11_RS00225	COG0628	permease
H1A11_RS00230	COG1435	thymidine kinase activity
H1A11_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H1A11_RS00255	COG2095	MarC family integral membrane protein
H1A11_RS00265	COG4206	TonB-dependent receptor
H1A11_RS00265	COG1629	transport
H1A11_RS00275	COG1629	transport
H1A11_RS00275	COG4206	TonB-dependent receptor
H1A11_RS00280	COG1373	ATPase (AAA superfamily
H1A11_RS00295	COG4206	TonB-dependent receptor
H1A11_RS00295	COG1629	transport
H1A11_RS00310	COG1629	transport
H1A11_RS00315	COG4974	Belongs to the 'phage' integrase family
H1A11_RS00320	COG1629	transport
H1A11_RS00320	COG4206	TonB-dependent receptor
H1A11_RS00335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1A11_RS00345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1A11_RS00345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1A11_RS00350	COG0531	amino acid
H1A11_RS00360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1A11_RS00365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1A11_RS00370	COG1162	GTPase activity
H1A11_RS00375	COG0233	cytoplasmic translational termination
H1A11_RS00380	COG0528	UMP kinase activity
H1A11_RS00390	COG0697	spore germination
H1A11_RS00395	COG2217	Heavy metal translocating P-type atpase
H1A11_RS00400	COG0534	Mate efflux family protein
H1A11_RS00455	COG0792	nuclease activity
H1A11_RS00480	COG1183	phosphatidylcholine synthase activity
H1A11_RS00485	COG0688	phosphatidylethanolamine metabolic process
H1A11_RS00515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1A11_RS00525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H1A11_RS00535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1A11_RS00545	COG2985	domain, Protein
H1A11_RS00545	COG0490	domain, Protein
H1A11_RS00550	COG2801	Transposase and inactivated derivatives
H1A11_RS00560	COG1506	peptidase
H1A11_RS00560	COG4946	Tricorn protease homolog
H1A11_RS00560	COG0823	Involved in the tonB-independent uptake of proteins
H1A11_RS00585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H1A11_RS00600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1A11_RS00605	COG0742	ribosomal rna small subunit methyltransferase
H1A11_RS00635	COG0739	heme binding
H1A11_RS00645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1A11_RS00650	COG1705	Flagellar rod assembly protein muramidase FlgJ
H1A11_RS00650	COG1388	LysM domain
H1A11_RS00660	COG1475	DNA binding
H1A11_RS00665	COG1192	Involved in chromosome partitioning
H1A11_RS00680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H1A11_RS00685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1A11_RS00700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1A11_RS00715	COG0138	bifunctional purine biosynthesis protein purh
H1A11_RS00725	COG2239	Acts as a magnesium transporter
H1A11_RS00730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1A11_RS00740	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1A11_RS00770	COG1119	ATPase activity
H1A11_RS00780	COG0668	transmembrane transport
H1A11_RS00795	COG1404	Belongs to the peptidase S8 family
H1A11_RS00795	COG4412	M6 family metalloprotease domain protein
H1A11_RS00800	COG0784	Response regulator, receiver
H1A11_RS00800	COG2205	protein histidine kinase activity
H1A11_RS00800	COG5002	protein histidine kinase activity
H1A11_RS00810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1A11_RS00815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1A11_RS00820	COG0713	ATP synthesis coupled electron transport
H1A11_RS00825	COG0839	Belongs to the complex I subunit 6 family
H1A11_RS00830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1A11_RS00835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H1A11_RS00840	COG0649	NAD binding
H1A11_RS00840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1A11_RS00845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1A11_RS00850	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1A11_RS00860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1A11_RS00865	COG0569	domain protein
H1A11_RS00870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H1A11_RS00885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1A11_RS00890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H1A11_RS00895	COG0805	protein transport
H1A11_RS00915	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H1A11_RS00920	COG3775	system Galactitol-specific IIC component
H1A11_RS00925	COG0546	phosphoglycolate phosphatase activity
H1A11_RS00930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H1A11_RS00935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H1A11_RS00945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H1A11_RS00950	COG1506	peptidase
H1A11_RS00950	COG0823	Involved in the tonB-independent uptake of proteins
H1A11_RS00955	COG4821	SIS domain
H1A11_RS00970	COG1242	4 iron, 4 sulfur cluster binding
H1A11_RS00980	COG0363	glucosamine-6-phosphate deaminase activity
H1A11_RS01035	COG0628	permease
H1A11_RS01040	COG0009	L-threonylcarbamoyladenylate synthase
H1A11_RS01045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1A11_RS01050	COG0561	phosphatase activity
H1A11_RS01065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H1A11_RS01080	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS01090	COG1073	alpha beta
H1A11_RS01110	COG3487	Iron-regulated protein
H1A11_RS01135	COG1333	cytochrome c biogenesis protein
H1A11_RS01135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H1A11_RS01160	COG1629	transport
H1A11_RS01160	COG4206	TonB-dependent receptor
H1A11_RS01175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H1A11_RS01185	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1A11_RS01190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H1A11_RS01190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H1A11_RS01195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1A11_RS01200	COG1078	dGTPase activity
H1A11_RS01205	COG0284	orotidine-5'-phosphate decarboxylase activity
H1A11_RS01210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H1A11_RS01215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H1A11_RS01220	COG1704	LemA family
H1A11_RS01235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H1A11_RS01240	COG2226	methyltransferase
H1A11_RS01245	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H1A11_RS01250	COG1702	phosphate starvation-inducible protein PhoH
H1A11_RS01270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H1A11_RS01275	COG0563	adenylate kinase activity
H1A11_RS01285	COG3104	oligopeptide transport
H1A11_RS01290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1A11_RS01290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1A11_RS01300	COG0101	tRNA pseudouridine synthase activity
H1A11_RS01310	COG1956	GAF domain-containing protein
H1A11_RS01320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H1A11_RS01330	COG2755	lipolytic protein G-D-S-L family
H1A11_RS01330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H1A11_RS01355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H1A11_RS01380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1A11_RS01385	COG0793	Belongs to the peptidase S41A family
H1A11_RS01390	COG2131	deaminase
H1A11_RS01400	COG0339	signal peptide processing
H1A11_RS01410	COG1970	mechanosensitive ion channel activity
H1A11_RS01415	COG0519	Catalyzes the synthesis of GMP from XMP
H1A11_RS01415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1A11_RS01420	COG0519	Catalyzes the synthesis of GMP from XMP
H1A11_RS01445	COG0438	transferase activity, transferring glycosyl groups
H1A11_RS01460	COG0297	glycogen (starch) synthase activity
H1A11_RS01465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H1A11_RS01470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H1A11_RS01480	COG0543	2 iron, 2 sulfur cluster binding
H1A11_RS01495	COG3279	Response regulator of the LytR AlgR family
H1A11_RS01500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H1A11_RS01505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H1A11_RS01510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H1A11_RS01525	COG1191	sigma factor activity
H1A11_RS01535	COG3537	Alpha-1,2-mannosidase
H1A11_RS01540	COG4771	TonB-dependent receptor
H1A11_RS01565	COG3537	Alpha-1,2-mannosidase
H1A11_RS01580	COG4206	TonB-dependent receptor
H1A11_RS01580	COG1629	transport
H1A11_RS01600	COG3537	Alpha-1,2-mannosidase
H1A11_RS01610	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H1A11_RS01615	COG3537	Alpha-1,2-mannosidase
H1A11_RS01630	COG0791	NLP P60 protein
H1A11_RS01645	COG0612	Peptidase, M16
H1A11_RS01650	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H1A11_RS01655	COG1597	lipid kinase activity
H1A11_RS01660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H1A11_RS01665	COG0534	Mate efflux family protein
H1A11_RS01675	COG3973	AAA domain
H1A11_RS01700	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H1A11_RS01705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H1A11_RS01710	COG1663	tetraacyldisaccharide 4'-kinase activity
H1A11_RS01715	COG0616	signal peptide processing
H1A11_RS01755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1A11_RS01760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H1A11_RS01765	COG0066	3-isopropylmalate dehydratase activity
H1A11_RS01770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1A11_RS01785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1A11_RS01795	COG0514	ATP-dependent DNA helicase (RecQ)
H1A11_RS01815	COG0735	belongs to the Fur family
H1A11_RS01820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H1A11_RS01835	COG0124	histidyl-tRNA synthetase
H1A11_RS01855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H1A11_RS01860	COG0459	protein refolding
H1A11_RS01885	COG0484	heat shock protein binding
H1A11_RS01905	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H1A11_RS01910	COG2086	electron transfer activity
H1A11_RS01930	COG4667	esterase of the alpha-beta hydrolase superfamily
H1A11_RS01935	COG4771	TonB-dependent receptor
H1A11_RS01945	COG1621	beta-fructofuranosidase activity
H1A11_RS01950	COG1621	beta-fructofuranosidase activity
H1A11_RS01960	COG1621	beta-fructofuranosidase activity
H1A11_RS01975	COG0745	RESPONSE REGULATOR receiver
H1A11_RS01975	COG2205	protein histidine kinase activity
H1A11_RS01975	COG3292	Two component regulator propeller
H1A11_RS02005	COG1966	Carbon starvation protein
H1A11_RS02030	COG1649	PFAM Uncharacterised BCR, COG1649
H1A11_RS02045	COG2205	protein histidine kinase activity
H1A11_RS02045	COG3292	Two component regulator propeller
H1A11_RS02045	COG0745	RESPONSE REGULATOR receiver
H1A11_RS02055	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H1A11_RS02060	COG1280	lysine exporter protein (LysE YggA)
H1A11_RS02075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H1A11_RS02120	COG0511	ligase activity, forming carbon-carbon bonds
H1A11_RS02135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1A11_RS02140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1A11_RS02150	COG1554	hydrolase, family 65, central catalytic
H1A11_RS02160	COG1609	Transcriptional regulator
H1A11_RS02170	COG3250	beta-galactosidase activity
H1A11_RS02175	COG4206	TonB-dependent receptor
H1A11_RS02175	COG1629	transport
H1A11_RS02180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1A11_RS02190	COG2819	hydrolase of the alpha beta superfamily
H1A11_RS02200	COG0366	Alpha amylase catalytic
H1A11_RS02215	COG0778	Nitroreductase
H1A11_RS02230	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H1A11_RS02235	COG0424	maF-like protein
H1A11_RS02250	COG0126	phosphoglycerate kinase activity
H1A11_RS02255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1A11_RS02265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H1A11_RS02275	COG1629	transport
H1A11_RS02285	COG2223	nitrite transmembrane transporter activity
H1A11_RS02295	COG4974	Belongs to the 'phage' integrase family
H1A11_RS02330	COG0551	DNA topoisomerase type I activity
H1A11_RS02330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H1A11_RS02350	COG2198	Histidine kinase
H1A11_RS02350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1A11_RS02350	COG0784	Response regulator, receiver
H1A11_RS02350	COG2205	protein histidine kinase activity
H1A11_RS02470	COG0358	DNA primase activity
H1A11_RS02585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H1A11_RS02590	COG1523	belongs to the glycosyl hydrolase 13 family
H1A11_RS02595	COG1119	ATPase activity
H1A11_RS02610	COG0671	phosphoesterase, PA-phosphatase related
H1A11_RS02625	COG5002	protein histidine kinase activity
H1A11_RS02630	COG0745	RESPONSE REGULATOR receiver
H1A11_RS02635	COG0668	transmembrane transport
H1A11_RS02645	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1A11_RS02660	COG3142	Participates in the control of copper homeostasis
H1A11_RS02665	COG1418	mRNA catabolic process
H1A11_RS02695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1A11_RS02700	COG2832	Protein of unknown function (DUF454)
H1A11_RS02705	COG0351	phosphomethylpyrimidine kinase
H1A11_RS02720	COG0602	queuosine metabolic process
H1A11_RS02735	COG1509	lysine 2,3-aminomutase activity
H1A11_RS02775	COG0741	lytic transglycosylase activity
H1A11_RS02775	COG1388	LysM domain
H1A11_RS02790	COG5002	protein histidine kinase activity
H1A11_RS02790	COG0784	Response regulator, receiver
H1A11_RS02790	COG2205	protein histidine kinase activity
H1A11_RS02830	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H1A11_RS02835	COG0346	lactoylglutathione lyase activity
H1A11_RS02840	COG0564	pseudouridine synthase activity
H1A11_RS02845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H1A11_RS02850	COG0542	response to heat
H1A11_RS02855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H1A11_RS02865	COG1028	Short-chain dehydrogenase reductase Sdr
H1A11_RS02880	COG1253	flavin adenine dinucleotide binding
H1A11_RS02905	COG0482	sulfurtransferase activity
H1A11_RS02925	COG2814	Major facilitator Superfamily
H1A11_RS02970	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H1A11_RS02975	COG3586	endonuclease activity
H1A11_RS02985	COG3645	SOS response
H1A11_RS03005	COG0732	type I restriction modification DNA specificity domain
H1A11_RS03010	COG0582	viral genome integration into host DNA
H1A11_RS03035	COG4974	Belongs to the 'phage' integrase family
H1A11_RS03050	COG0813	purine-nucleoside phosphorylase activity
H1A11_RS03055	COG4864	UPF0365 protein
H1A11_RS03070	COG0037	tRNA processing
H1A11_RS03080	COG1477	protein flavinylation
H1A11_RS03085	COG1971	Probably functions as a manganese efflux pump
H1A11_RS03100	COG0463	Glycosyl transferase, family 2
H1A11_RS03120	COG1629	transport
H1A11_RS03120	COG4206	TonB-dependent receptor
H1A11_RS03125	COG0561	phosphatase activity
H1A11_RS03150	COG0148	phosphopyruvate hydratase activity
H1A11_RS03155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H1A11_RS03160	COG1082	Xylose isomerase domain protein TIM barrel
H1A11_RS03175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H1A11_RS03180	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1A11_RS03185	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H1A11_RS03195	COG0254	rRNA binding
H1A11_RS03205	COG0191	fructose-bisphosphate aldolase activity
H1A11_RS03210	COG0366	Alpha amylase catalytic
H1A11_RS03225	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H1A11_RS03230	COG0511	ligase activity, forming carbon-carbon bonds
H1A11_RS03240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1A11_RS03255	COG2204	response regulator
H1A11_RS03260	COG4191	Histidine kinase
H1A11_RS03295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1A11_RS03305	COG1979	alcohol dehydrogenase
H1A11_RS03310	COG1530	ribonuclease E activity
H1A11_RS03315	COG0776	regulation of translation
H1A11_RS03320	COG1194	a g-specific adenine glycosylase
H1A11_RS03325	COG0629	single-stranded DNA binding
H1A11_RS03340	COG3033	Beta-eliminating lyase
H1A11_RS03345	COG5002	protein histidine kinase activity
H1A11_RS03350	COG0745	RESPONSE REGULATOR receiver
H1A11_RS03360	COG4771	TonB-dependent receptor
H1A11_RS03375	COG0488	(ABC) transporter
H1A11_RS03395	COG3591	Belongs to the peptidase S1B family
H1A11_RS03400	COG3591	Belongs to the peptidase S1B family
H1A11_RS03405	COG0641	radical SAM
H1A11_RS03420	COG1408	metallophosphoesterase
H1A11_RS03435	COG1410	methionine synthase
H1A11_RS03435	COG0646	methionine synthase
H1A11_RS03440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H1A11_RS03445	COG0463	Glycosyl transferase, family 2
H1A11_RS03450	COG1940	carbohydrate kinase activity
H1A11_RS03465	COG2814	Major facilitator Superfamily
H1A11_RS03475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1A11_RS03510	COG4771	TonB-dependent receptor
H1A11_RS03515	COG0702	epimerase
H1A11_RS03525	COG3345	alpha-galactosidase
H1A11_RS03540	COG3345	alpha-galactosidase
H1A11_RS03550	COG1082	Xylose isomerase domain protein TIM barrel
H1A11_RS03590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1A11_RS03600	COG1032	radical SAM domain protein
H1A11_RS03625	COG0363	glucosamine-6-phosphate deaminase activity
H1A11_RS03635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1A11_RS03680	COG3757	hydrolase, family 25
H1A11_RS03685	COG2264	protein methyltransferase activity
H1A11_RS03720	COG1592	Rubrerythrin
H1A11_RS03720	COG1773	rubredoxin
H1A11_RS03730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H1A11_RS03730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1A11_RS03735	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H1A11_RS03775	COG0698	ribose 5-phosphate isomerase
H1A11_RS03790	COG1070	Carbohydrate kinase
H1A11_RS03795	COG2160	L-arabinose isomerase activity
H1A11_RS03820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H1A11_RS03835	COG1482	cell wall glycoprotein biosynthetic process
H1A11_RS03855	COG0513	Belongs to the DEAD box helicase family
H1A11_RS03870	COG1218	3'(2'),5'-bisphosphate nucleotidase
H1A11_RS03875	COG3273	potassium ion transport
H1A11_RS03875	COG0471	metal ion transport
H1A11_RS03880	COG0529	Catalyzes the synthesis of activated sulfate
H1A11_RS03885	COG0175	sulfate reduction
H1A11_RS03890	COG2895	sulfate adenylyltransferase (ATP) activity
H1A11_RS03925	COG4974	Belongs to the 'phage' integrase family
H1A11_RS03950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H1A11_RS03955	COG0242	peptide deformylase activity
H1A11_RS03965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H1A11_RS03970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H1A11_RS03975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H1A11_RS03980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H1A11_RS03985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1A11_RS03990	COG1013	pyruvate-flavodoxin oxidoreductase activity
H1A11_RS03990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H1A11_RS03990	COG0674	pyruvate-flavodoxin oxidoreductase activity
H1A11_RS03990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H1A11_RS04000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1A11_RS04005	COG0823	Involved in the tonB-independent uptake of proteins
H1A11_RS04010	COG3507	Belongs to the glycosyl hydrolase 43 family
H1A11_RS04045	COG0484	heat shock protein binding
H1A11_RS04050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H1A11_RS04055	COG0488	(ABC) transporter
H1A11_RS04075	COG2183	response to ionizing radiation
H1A11_RS04080	COG2202	Pas domain
H1A11_RS04080	COG2205	protein histidine kinase activity
H1A11_RS04095	COG4771	TonB-dependent receptor
H1A11_RS04100	COG1917	Cupin 2, conserved barrel domain protein
H1A11_RS04100	COG4977	sequence-specific DNA binding
H1A11_RS04125	COG0534	Mate efflux family protein
H1A11_RS04150	COG0306	phosphate transporter
H1A11_RS04160	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H1A11_RS04170	COG0318	PFAM AMP-dependent synthetase and ligase
H1A11_RS04180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1A11_RS04190	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H1A11_RS04195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H1A11_RS04200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H1A11_RS04205	COG0363	glucosamine-6-phosphate deaminase activity
H1A11_RS04215	COG0259	pyridoxamine-phosphate oxidase activity
H1A11_RS04280	COG3279	Response regulator of the LytR AlgR family
H1A11_RS04290	COG1136	(ABC) transporter
H1A11_RS04290	COG0577	efflux transmembrane transporter activity
H1A11_RS04295	COG1136	(ABC) transporter
H1A11_RS04325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1A11_RS04335	COG0534	Mate efflux family protein
H1A11_RS04345	COG1177	transmembrane transport
H1A11_RS04350	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1A11_RS04355	COG3842	ATPase activity
H1A11_RS04380	COG4221	oxidoreductase activity
H1A11_RS04395	COG0488	(ABC) transporter
H1A11_RS04415	COG0513	Belongs to the DEAD box helicase family
H1A11_RS04420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H1A11_RS04425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1A11_RS04440	COG0545	Peptidyl-prolyl cis-trans isomerase
H1A11_RS04450	COG0534	Mate efflux family protein
H1A11_RS04455	COG1929	Belongs to the glycerate kinase type-1 family
H1A11_RS04460	COG0110	maltose O-acetyltransferase activity
H1A11_RS04465	COG1917	Cupin 2, conserved barrel domain protein
H1A11_RS04465	COG2207	Transcriptional regulator
H1A11_RS04470	COG1739	Uncharacterized protein family UPF0029
H1A11_RS04480	COG0778	Nitroreductase
H1A11_RS04490	COG1725	Transcriptional regulator
H1A11_RS04500	COG1122	ATPase activity
H1A11_RS04510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H1A11_RS04510	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H1A11_RS04515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1A11_RS04520	COG0357	Ribosomal RNA small subunit methyltransferase G
H1A11_RS04545	COG2217	Heavy metal translocating P-type atpase
H1A11_RS04555	COG0321	lipoyl(octanoyl) transferase activity
H1A11_RS04600	COG0562	UDP-galactopyranose mutase
H1A11_RS04615	COG3385	transposase activity
H1A11_RS04625	COG0438	transferase activity, transferring glycosyl groups
H1A11_RS04625	COG0297	glycogen (starch) synthase activity
H1A11_RS04635	COG0463	Glycosyl transferase, family 2
H1A11_RS04650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H1A11_RS04675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H1A11_RS04690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1A11_RS04690	COG0072	phenylalanine-tRNA ligase activity
H1A11_RS04695	COG0217	transcriptional regulatory protein
H1A11_RS04705	COG1914	H( )-stimulated, divalent metal cation uptake system
H1A11_RS04710	COG0708	Exodeoxyribonuclease III
H1A11_RS04725	COG0481	GTPase activity
H1A11_RS04730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H1A11_RS04735	COG5002	protein histidine kinase activity
H1A11_RS04750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1A11_RS04755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1A11_RS04775	COG0612	Peptidase, M16
H1A11_RS04790	COG2205	protein histidine kinase activity
H1A11_RS04790	COG0784	Response regulator, receiver
H1A11_RS04795	COG0463	Glycosyl transferase, family 2
H1A11_RS04810	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H1A11_RS04815	COG1805	sodium ion transport
H1A11_RS04820	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H1A11_RS04830	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H1A11_RS04840	COG2233	PERMEase
H1A11_RS04845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H1A11_RS04855	COG0024	Methionine aminopeptidase
H1A11_RS04865	COG0420	3'-5' exonuclease activity
H1A11_RS04890	COG2814	Major facilitator Superfamily
H1A11_RS04905	COG0564	pseudouridine synthase activity
H1A11_RS04910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H1A11_RS04915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1A11_RS04915	COG0574	Belongs to the PEP-utilizing enzyme family
H1A11_RS05045	COG0784	Response regulator, receiver
H1A11_RS05045	COG5002	protein histidine kinase activity
H1A11_RS05045	COG2205	protein histidine kinase activity
H1A11_RS05110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H1A11_RS05125	COG1678	Uncharacterized ACR, COG1678
H1A11_RS05130	COG4771	TonB-dependent receptor
H1A11_RS05345	COG1086	Polysaccharide biosynthesis protein
H1A11_RS05360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H1A11_RS05365	COG0438	transferase activity, transferring glycosyl groups
H1A11_RS05390	COG1028	Short-chain dehydrogenase reductase Sdr
H1A11_RS05395	COG0318	PFAM AMP-dependent synthetase and ligase
H1A11_RS05410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1A11_RS05415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1A11_RS05420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1A11_RS05495	COG0110	maltose O-acetyltransferase activity
H1A11_RS05505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H1A11_RS05520	COG0738	Major facilitator superfamily
H1A11_RS05530	COG2059	Chromate
H1A11_RS05540	COG3969	phosphoadenosine phosphosulfate
H1A11_RS05545	COG1475	DNA binding
H1A11_RS05550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1A11_RS05565	COG1074	ATP-dependent DNA helicase activity
H1A11_RS05575	COG0556	nucleotide-excision repair
H1A11_RS05580	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1A11_RS05610	COG1388	LysM domain
H1A11_RS05610	COG3942	CHAP domain
H1A11_RS05615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H1A11_RS05620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1A11_RS05625	COG3104	oligopeptide transport
H1A11_RS05640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H1A11_RS05650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H1A11_RS05655	COG1695	Transcriptional regulator
H1A11_RS05675	COG1086	Polysaccharide biosynthesis protein
H1A11_RS05680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1A11_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
H1A11_RS05725	COG2089	acid synthase
H1A11_RS05800	COG1216	Glycosyl transferase, family 2
H1A11_RS05855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1A11_RS05860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H1A11_RS05875	COG3250	beta-galactosidase activity
H1A11_RS05880	COG0657	acetylesterase activity
H1A11_RS05880	COG2755	lipolytic protein G-D-S-L family
H1A11_RS05905	COG3059	membrane
H1A11_RS05920	COG1120	ATPase activity
H1A11_RS05925	COG0534	Mate efflux family protein
H1A11_RS05935	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H1A11_RS05965	COG4771	TonB-dependent receptor
H1A11_RS05985	COG1429	ligase activity, forming nitrogen-metal bonds
H1A11_RS06010	COG0439	Biotin carboxylase
H1A11_RS06020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H1A11_RS06030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H1A11_RS06040	COG1797	cobyrinic acid a,c-diamide synthase activity
H1A11_RS06045	COG2096	Adenosyltransferase
H1A11_RS06050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H1A11_RS06070	COG1492	cobalamin metabolic process
H1A11_RS06080	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H1A11_RS06085	COG2205	protein histidine kinase activity
H1A11_RS06085	COG2202	Pas domain
H1A11_RS06090	COG2205	protein histidine kinase activity
H1A11_RS06090	COG2202	Pas domain
H1A11_RS06100	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H1A11_RS06105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H1A11_RS06120	COG0442	prolyl-tRNA aminoacylation
H1A11_RS06190	COG0438	transferase activity, transferring glycosyl groups
H1A11_RS06205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1A11_RS06210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H1A11_RS06215	COG0438	transferase activity, transferring glycosyl groups
H1A11_RS06230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1A11_RS06235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H1A11_RS06245	COG1506	peptidase
H1A11_RS06245	COG0823	Involved in the tonB-independent uptake of proteins
H1A11_RS06250	COG0534	Mate efflux family protein
H1A11_RS06260	COG0504	CTP synthase activity
H1A11_RS06280	COG4656	Part of a membrane complex involved in electron transport
H1A11_RS06285	COG4658	electron transport chain
H1A11_RS06290	COG4659	FMN binding
H1A11_RS06295	COG4660	Part of a membrane complex involved in electron transport
H1A11_RS06300	COG4657	Part of a membrane complex involved in electron transport
H1A11_RS06305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H1A11_RS06325	COG0356	it plays a direct role in the translocation of protons across the membrane
H1A11_RS06330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H1A11_RS06335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H1A11_RS06340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H1A11_RS06345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H1A11_RS06350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H1A11_RS06355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1A11_RS06390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H1A11_RS06400	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H1A11_RS06405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H1A11_RS06420	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H1A11_RS06425	COG0540	Belongs to the ATCase OTCase family
H1A11_RS06430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1A11_RS06440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H1A11_RS06455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H1A11_RS06460	COG2205	protein histidine kinase activity
H1A11_RS06530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H1A11_RS06570	COG0351	phosphomethylpyrimidine kinase
H1A11_RS06575	COG0352	thiamine-phosphate diphosphorylase activity
H1A11_RS06590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H1A11_RS06595	COG2022	thiamine diphosphate biosynthetic process
H1A11_RS06600	COG0352	thiamine-phosphate diphosphorylase activity
H1A11_RS06610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1A11_RS06625	COG2115	Belongs to the xylose isomerase family
H1A11_RS06630	COG0477	Major facilitator Superfamily
H1A11_RS06630	COG2814	Major facilitator Superfamily
H1A11_RS06635	COG3153	acetyltransferase
H1A11_RS06635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1A11_RS06645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H1A11_RS06655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H1A11_RS06670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1A11_RS06695	COG4974	Belongs to the 'phage' integrase family
H1A11_RS06735	COG2194	sulfuric ester hydrolase activity
H1A11_RS06755	COG3387	PFAM Glycoside hydrolase 15-related
H1A11_RS06765	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1A11_RS06770	COG4974	Belongs to the 'phage' integrase family
H1A11_RS06775	COG4974	Belongs to the 'phage' integrase family
H1A11_RS06820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H1A11_RS06870	COG1132	(ABC) transporter
H1A11_RS06930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H1A11_RS06945	COG1904	glucuronate isomerase
H1A11_RS06955	COG0246	Mannitol dehydrogenase
H1A11_RS06990	COG0513	Belongs to the DEAD box helicase family
H1A11_RS06995	COG0560	Phosphoserine phosphatase
H1A11_RS06995	COG3830	Belongs to the UPF0237 family
H1A11_RS07010	COG0343	queuine tRNA-ribosyltransferase activity
H1A11_RS07015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H1A11_RS07020	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H1A11_RS07075	COG2003	Belongs to the UPF0758 family
H1A11_RS07085	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H1A11_RS07135	COG1136	(ABC) transporter
H1A11_RS07155	COG2801	Transposase and inactivated derivatives
H1A11_RS07170	COG2204	response regulator
H1A11_RS07175	COG2205	protein histidine kinase activity
H1A11_RS07175	COG0784	Response regulator, receiver
H1A11_RS07175	COG2198	Histidine kinase
H1A11_RS07250	COG1475	DNA binding
H1A11_RS07275	COG0501	Belongs to the peptidase M48B family
H1A11_RS07280	COG0156	8-amino-7-oxononanoate synthase activity
H1A11_RS07285	COG1597	lipid kinase activity
H1A11_RS07290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H1A11_RS07305	COG2957	Belongs to the agmatine deiminase family
H1A11_RS07315	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H1A11_RS07320	COG0390	transport system, permease component
H1A11_RS07325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H1A11_RS07370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1A11_RS07385	COG0543	2 iron, 2 sulfur cluster binding
H1A11_RS07390	COG0167	dihydroorotate dehydrogenase activity
H1A11_RS07395	COG0336	Belongs to the RNA methyltransferase TrmD family
H1A11_RS07400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H1A11_RS07405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1A11_RS07430	COG0542	response to heat
H1A11_RS07435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H1A11_RS07485	COG2304	oxidoreductase activity
H1A11_RS07500	COG0714	Associated with various cellular activities
H1A11_RS07510	COG0776	regulation of translation
H1A11_RS07515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H1A11_RS07520	COG0552	protein localization to endoplasmic reticulum
H1A11_RS07530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H1A11_RS07535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H1A11_RS07540	COG1546	Belongs to the CinA family
H1A11_RS07540	COG1058	Belongs to the CinA family
H1A11_RS07545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H1A11_RS07555	COG0305	Participates in initiation and elongation during chromosome replication
H1A11_RS07560	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H1A11_RS07570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H1A11_RS07580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1A11_RS07585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H1A11_RS07595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H1A11_RS07600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1A11_RS07605	COG0534	Mate efflux family protein
H1A11_RS07615	COG0577	efflux transmembrane transporter activity
H1A11_RS07615	COG1136	(ABC) transporter
H1A11_RS07620	COG1136	(ABC) transporter
H1A11_RS07645	COG2205	protein histidine kinase activity
H1A11_RS07650	COG3263	regulation of cellular component size
H1A11_RS07655	COG0318	PFAM AMP-dependent synthetase and ligase
H1A11_RS07665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H1A11_RS07675	COG2755	lipolytic protein G-D-S-L family
H1A11_RS07675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H1A11_RS07685	COG0842	Transport permease protein
H1A11_RS07690	COG1131	(ABC) transporter
H1A11_RS07705	COG1917	Cupin 2, conserved barrel domain protein
H1A11_RS07705	COG2207	Transcriptional regulator
H1A11_RS07710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1A11_RS07715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1A11_RS07720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1A11_RS07725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H1A11_RS07730	COG0505	Belongs to the CarA family
H1A11_RS07740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1A11_RS07745	COG0069	glutamate synthase activity
H1A11_RS07745	COG0070	glutamate synthase
H1A11_RS07745	COG0067	glutamate synthase
H1A11_RS07755	COG0367	asparagine synthase
H1A11_RS07775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1A11_RS07780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1A11_RS07800	COG3594	Acyltransferase
H1A11_RS07805	COG0438	transferase activity, transferring glycosyl groups
H1A11_RS07845	COG1216	Glycosyl transferase, family 2
H1A11_RS07925	COG0436	Aminotransferase
H1A11_RS07955	COG0133	tryptophan synthase activity
H1A11_RS07960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1A11_RS07965	COG0512	Glutamine amidotransferase of anthranilate synthase
H1A11_RS07965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1A11_RS07970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1A11_RS07975	COG0134	indole-3-glycerol-phosphate synthase activity
H1A11_RS07980	COG0135	phosphoribosylanthranilate isomerase activity
H1A11_RS07985	COG0159	tryptophan synthase activity
H1A11_RS07990	COG0252	asparaginase activity
H1A11_RS08000	COG0745	RESPONSE REGULATOR receiver
H1A11_RS08080	COG1442	glycosyl transferase family 8
H1A11_RS08080	COG1216	Glycosyl transferase, family 2
H1A11_RS08085	COG1216	Glycosyl transferase, family 2
H1A11_RS08090	COG1216	Glycosyl transferase, family 2
H1A11_RS08120	COG1609	Transcriptional regulator
H1A11_RS08135	COG0228	four-way junction DNA binding
H1A11_RS08140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H1A11_RS08170	COG0588	phosphoglycerate mutase activity
H1A11_RS08180	COG0716	FMN binding
H1A11_RS08185	COG0058	SHG alpha-glucan phosphorylase activity
H1A11_RS08215	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
H1A11_RS08255	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1A11_RS08270	COG0305	Participates in initiation and elongation during chromosome replication
H1A11_RS08295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H1A11_RS08295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H1A11_RS08310	COG2226	methyltransferase
H1A11_RS08320	COG1215	transferase activity, transferring glycosyl groups
H1A11_RS08325	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1A11_RS08330	COG0436	Aminotransferase
H1A11_RS08340	COG2205	protein histidine kinase activity
H1A11_RS08340	COG0784	Response regulator, receiver
H1A11_RS08370	COG0577	efflux transmembrane transporter activity
H1A11_RS08385	COG0577	efflux transmembrane transporter activity
H1A11_RS08390	COG1136	(ABC) transporter
H1A11_RS08395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1A11_RS08400	COG3942	CHAP domain
H1A11_RS08400	COG1705	Flagellar rod assembly protein muramidase FlgJ
H1A11_RS08405	COG0295	cytidine deaminase activity
H1A11_RS08415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H1A11_RS08495	COG0484	heat shock protein binding
H1A11_RS08535	COG0358	DNA primase activity
H1A11_RS08625	COG1192	Involved in chromosome partitioning
H1A11_RS08765	COG2205	protein histidine kinase activity
H1A11_RS08765	COG0784	Response regulator, receiver
H1A11_RS08770	COG2204	response regulator
H1A11_RS08795	COG4974	Belongs to the 'phage' integrase family
H1A11_RS08800	COG4974	Belongs to the 'phage' integrase family
H1A11_RS08805	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H1A11_RS08835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1A11_RS08845	COG0739	heme binding
H1A11_RS08850	COG0686	Belongs to the AlaDH PNT family
H1A11_RS08860	COG0076	glutamate decarboxylase activity
H1A11_RS08865	COG2066	Belongs to the glutaminase family
H1A11_RS08875	COG0531	amino acid
H1A11_RS08900	COG1595	DNA-templated transcription, initiation
H1A11_RS08925	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H1A11_RS08950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H1A11_RS08955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1A11_RS08965	COG4948	Mandelate Racemase Muconate Lactonizing
H1A11_RS09015	COG4974	Belongs to the 'phage' integrase family
H1A11_RS09025	COG0778	Nitroreductase
H1A11_RS09035	COG0704	Plays a role in the regulation of phosphate uptake
H1A11_RS09040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1A11_RS09045	COG0581	inorganic phosphate transmembrane transporter activity
H1A11_RS09050	COG0573	inorganic phosphate transmembrane transporter activity
H1A11_RS09055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1A11_RS09060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1A11_RS09070	COG0586	Pfam SNARE associated Golgi protein
H1A11_RS09075	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H1A11_RS09090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1A11_RS09095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1A11_RS09100	COG0656	L-ascorbic acid biosynthetic process
H1A11_RS09110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H1A11_RS09115	COG0318	PFAM AMP-dependent synthetase and ligase
H1A11_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
H1A11_RS09130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H1A11_RS09145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H1A11_RS09155	COG1216	Glycosyl transferase, family 2
H1A11_RS09195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H1A11_RS09200	COG0167	dihydroorotate dehydrogenase activity
H1A11_RS09210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H1A11_RS09230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1A11_RS09235	COG0497	DNA recombination
H1A11_RS09250	COG0592	DNA-directed DNA polymerase activity
H1A11_RS09265	COG0321	lipoyl(octanoyl) transferase activity
H1A11_RS09265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H1A11_RS09270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H1A11_RS09285	COG0156	8-amino-7-oxononanoate synthase activity
H1A11_RS09295	COG0019	diaminopimelate decarboxylase activity
H1A11_RS09300	COG0527	aspartate kinase activity
H1A11_RS09305	COG2884	Cell division ATP-binding protein ftsE
H1A11_RS09310	COG0140	phosphoribosyl-ATP diphosphatase activity
H1A11_RS09310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H1A11_RS09315	COG0107	imidazoleglycerol-phosphate synthase activity
H1A11_RS09320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H1A11_RS09325	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1A11_RS09330	COG0788	formyltetrahydrofolate deformylase activity
H1A11_RS09350	COG0561	phosphatase activity
H1A11_RS09355	COG2207	Transcriptional regulator
H1A11_RS09355	COG1609	Transcriptional regulator
H1A11_RS09365	COG0714	Associated with various cellular activities
H1A11_RS09400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H1A11_RS09415	COG1151	hydroxylamine reductase activity
H1A11_RS09440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H1A11_RS09445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H1A11_RS09455	COG4206	TonB-dependent receptor
H1A11_RS09455	COG1629	transport
H1A11_RS09460	COG0702	epimerase
H1A11_RS09485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1A11_RS09490	COG1741	Belongs to the pirin family
H1A11_RS09505	COG0346	lactoylglutathione lyase activity
H1A11_RS09530	COG1918	ferrous iron import across plasma membrane
H1A11_RS09530	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H1A11_RS09535	COG0037	tRNA processing
H1A11_RS09550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1A11_RS09555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H1A11_RS09570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H1A11_RS09580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H1A11_RS09635	COG2204	response regulator
H1A11_RS09640	COG2205	protein histidine kinase activity
H1A11_RS09640	COG2198	Histidine kinase
H1A11_RS09640	COG0784	Response regulator, receiver
H1A11_RS09660	COG2217	Heavy metal translocating P-type atpase
H1A11_RS09710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1A11_RS09715	COG1120	ATPase activity
H1A11_RS09740	COG1475	DNA binding
H1A11_RS09770	COG4206	TonB-dependent receptor
H1A11_RS09780	COG1741	Belongs to the pirin family
H1A11_RS09785	COG2353	YceI-like domain
H1A11_RS09790	COG1335	isochorismatase
H1A11_RS09795	COG1917	Cupin 2, conserved barrel domain protein
H1A11_RS09795	COG4977	sequence-specific DNA binding
H1A11_RS09800	COG0697	spore germination
H1A11_RS09935	COG1196	nuclear chromosome segregation
H1A11_RS09975	COG4974	Belongs to the 'phage' integrase family
H1A11_RS09985	COG4804	nuclease activity
H1A11_RS10045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H1A11_RS10135	COG0358	DNA primase activity
H1A11_RS10165	COG1193	negative regulation of DNA recombination
H1A11_RS10170	COG1760	l-serine dehydratase
H1A11_RS10185	COG3850	Histidine kinase
H1A11_RS10185	COG5002	protein histidine kinase activity
H1A11_RS10190	COG0745	RESPONSE REGULATOR receiver
H1A11_RS10240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H1A11_RS10245	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
H1A11_RS10280	COG4139	cobalamin transport
H1A11_RS10300	COG0561	phosphatase activity
H1A11_RS10305	COG0514	ATP-dependent DNA helicase (RecQ)
H1A11_RS10320	COG0443	Heat shock 70 kDa protein
H1A11_RS10345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1A11_RS10350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H1A11_RS10365	COG1595	DNA-templated transcription, initiation
H1A11_RS10380	COG2855	membrane
H1A11_RS10385	COG0583	DNA-binding transcription factor activity
H1A11_RS10395	COG0542	response to heat
H1A11_RS10405	COG0237	dephospho-CoA kinase activity
H1A11_RS10415	COG1862	Preprotein translocase
H1A11_RS10420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H1A11_RS10430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H1A11_RS10435	COG0193	aminoacyl-tRNA hydrolase activity
H1A11_RS10440	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H1A11_RS10445	COG0673	inositol 2-dehydrogenase activity
H1A11_RS10450	COG4651	solute:proton antiporter activity
H1A11_RS10450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1A11_RS10455	COG0131	Imidazoleglycerol-phosphate dehydratase
H1A11_RS10460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1A11_RS10465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H1A11_RS10470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H1A11_RS10495	COG4232	protein-disulfide reductase activity
H1A11_RS10505	COG0572	uridine kinase
H1A11_RS10510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H1A11_RS10515	COG1410	methionine synthase
H1A11_RS10515	COG0646	methionine synthase
H1A11_RS10520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H1A11_RS10585	COG2003	Belongs to the UPF0758 family
H1A11_RS10645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1A11_RS10720	COG0534	Mate efflux family protein
H1A11_RS10725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1A11_RS10730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1A11_RS10745	COG2217	Heavy metal translocating P-type atpase
H1A11_RS10805	COG2003	Belongs to the UPF0758 family
H1A11_RS10810	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1A11_RS10835	COG4974	Belongs to the 'phage' integrase family
H1A11_RS10840	COG4974	Belongs to the 'phage' integrase family
H1A11_RS10845	COG4974	Belongs to the 'phage' integrase family
H1A11_RS10870	COG0010	Belongs to the arginase family
H1A11_RS10875	COG0058	SHG alpha-glucan phosphorylase activity
H1A11_RS10880	COG4651	solute:proton antiporter activity
H1A11_RS10880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1A11_RS10885	COG0205	6-phosphofructokinase activity
H1A11_RS10900	COG0588	phosphoglycerate mutase activity
H1A11_RS10905	COG1830	Aldolase
H1A11_RS10915	COG2095	MarC family integral membrane protein
H1A11_RS10945	COG1477	protein flavinylation
H1A11_RS10965	COG2706	6-phosphogluconolactonase activity
H1A11_RS11005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H1A11_RS11015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H1A11_RS11025	COG1253	flavin adenine dinucleotide binding
H1A11_RS11055	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
H1A11_RS11060	COG0653	protein targeting
H1A11_RS11090	COG0561	phosphatase activity
H1A11_RS11095	COG1629	transport
H1A11_RS11095	COG4206	TonB-dependent receptor
H1A11_RS11125	COG0525	valine-tRNA ligase activity
H1A11_RS11135	COG3956	TIGRFAM MazG family protein
H1A11_RS11155	COG1234	tRNA 3'-trailer cleavage
H1A11_RS11195	COG0492	ferredoxin-NADP+ reductase activity
H1A11_RS11205	COG1674	ftsk spoiiie
H1A11_RS11235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H1A11_RS11240	COG2211	Major facilitator Superfamily
H1A11_RS11260	COG1136	(ABC) transporter
H1A11_RS11275	COG0471	metal ion transport
H1A11_RS11275	COG0490	domain, Protein
H1A11_RS11295	COG1733	regulation of RNA biosynthetic process
H1A11_RS11310	COG2207	Transcriptional regulator
H1A11_RS11310	COG1917	Cupin 2, conserved barrel domain protein
H1A11_RS11325	COG2873	o-acetylhomoserine
H1A11_RS11340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1A11_RS11345	COG0523	cobalamin synthesis protein
H1A11_RS11350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H1A11_RS11355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H1A11_RS11365	COG0194	GDP metabolic process
H1A11_RS11375	COG1214	PFAM Peptidase M22, glycoprotease
H1A11_RS11385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H1A11_RS11390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H1A11_RS11400	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H1A11_RS11405	COG0750	zinc metalloprotease
H1A11_RS11410	COG0673	inositol 2-dehydrogenase activity
H1A11_RS11415	COG0632	four-way junction helicase activity
H1A11_RS11425	COG0006	proline dipeptidase activity
H1A11_RS11450	COG4771	TonB-dependent receptor
H1A11_RS11465	COG0363	glucosamine-6-phosphate deaminase activity
H1A11_RS11470	COG1940	carbohydrate kinase activity
H1A11_RS11475	COG0745	RESPONSE REGULATOR receiver
H1A11_RS11475	COG3292	Two component regulator propeller
H1A11_RS11475	COG2205	protein histidine kinase activity
H1A11_RS11475	COG0745	RESPONSE REGULATOR receiver
H1A11_RS11475	COG2205	protein histidine kinase activity
H1A11_RS11475	COG3292	Two component regulator propeller
H1A11_RS11485	COG1408	metallophosphoesterase
H1A11_RS11490	COG1575	Belongs to the MenA family. Type 1 subfamily
H1A11_RS11500	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H1A11_RS11510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H1A11_RS11515	COG1082	Xylose isomerase domain protein TIM barrel
H1A11_RS11525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H1A11_RS11530	COG3069	C4-dicarboxylate transmembrane transporter activity
H1A11_RS11540	COG4771	TonB-dependent receptor
H1A11_RS11555	COG0617	tRNA 3'-terminal CCA addition
H1A11_RS11565	COG2204	response regulator
H1A11_RS11570	COG0488	(ABC) transporter
H1A11_RS11575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1A11_RS11610	COG4771	TonB-dependent receptor
H1A11_RS11625	COG1595	DNA-templated transcription, initiation
H1A11_RS11640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H1A11_RS11650	COG1522	sequence-specific DNA binding
H1A11_RS11680	COG0811	peptide transport
H1A11_RS11690	COG0084	hydrolase, TatD family'
H1A11_RS11710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H1A11_RS11715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H1A11_RS11720	COG0205	6-phosphofructokinase activity
H1A11_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
H1A11_RS11730	COG1902	pentaerythritol trinitrate reductase activity
H1A11_RS11730	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1A11_RS11740	COG0372	Belongs to the citrate synthase family
H1A11_RS11755	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H1A11_RS11760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H1A11_RS11770	COG0440	acetolactate synthase activity
H1A11_RS11775	COG0028	Belongs to the TPP enzyme family
H1A11_RS11780	COG0129	dihydroxy-acid dehydratase activity
H1A11_RS11785	COG1047	Peptidyl-prolyl cis-trans
H1A11_RS11790	COG3681	Belongs to the UPF0597 family
H1A11_RS11805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1A11_RS11810	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H1A11_RS11820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H1A11_RS11820	COG0551	DNA topoisomerase type I activity
H1A11_RS11825	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H1A11_RS11825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H1A11_RS11830	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H1A11_RS11835	COG0569	domain protein
H1A11_RS11835	COG2985	domain, Protein
H1A11_RS11855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H1A11_RS11860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H1A11_RS11865	COG0166	Belongs to the GPI family
H1A11_RS11870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1A11_RS11890	COG0789	Transcriptional regulator
H1A11_RS11900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H1A11_RS11910	COG2502	aspartate--ammonia ligase
H1A11_RS11915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H1A11_RS11930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H1A11_RS11940	COG0463	Glycosyl transferase, family 2
H1A11_RS11975	COG0860	N-Acetylmuramoyl-L-alanine amidase
H1A11_RS11985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H1A11_RS12000	COG1640	4-alpha-glucanotransferase
H1A11_RS12005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H1A11_RS12025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H1A11_RS12030	COG0318	PFAM AMP-dependent synthetase and ligase
H1A11_RS12040	COG0724	RNA recognition motif
H1A11_RS12055	COG0359	binds to the 23S rRNA
H1A11_RS12060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H1A11_RS12065	COG0360	Binds together with S18 to 16S ribosomal RNA
H1A11_RS12090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H1A11_RS12110	COG0519	Catalyzes the synthesis of GMP from XMP
H1A11_RS12115	COG3250	beta-galactosidase activity
H1A11_RS12155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1A11_RS12190	COG3275	phosphorelay sensor kinase activity
H1A11_RS12200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H1A11_RS12205	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H1A11_RS12210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H1A11_RS12220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H1A11_RS12230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1A11_RS12235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H1A11_RS12245	COG0009	L-threonylcarbamoyladenylate synthase
H1A11_RS12255	COG1609	Transcriptional regulator
H1A11_RS12255	COG2207	Transcriptional regulator
H1A11_RS12260	COG5183	chlorophyll binding
H1A11_RS12260	COG2133	pyrroloquinoline quinone binding
H1A11_RS12265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H1A11_RS12280	COG1785	Belongs to the alkaline phosphatase family
H1A11_RS12290	COG3537	Alpha-1,2-mannosidase
H1A11_RS12300	COG4206	TonB-dependent receptor
H1A11_RS12300	COG1629	transport
H1A11_RS12305	COG1940	carbohydrate kinase activity
H1A11_RS12310	COG0823	Involved in the tonB-independent uptake of proteins
H1A11_RS12315	COG3022	response to hydroperoxide
H1A11_RS12320	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H1A11_RS12320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1A11_RS12325	COG0514	ATP-dependent DNA helicase (RecQ)
H1A11_RS12345	COG0436	Aminotransferase
H1A11_RS12350	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H1A11_RS12360	COG0358	DNA primase activity
H1A11_RS12365	COG0302	gtp cyclohydrolase
H1A11_RS12375	COG0149	triose-phosphate isomerase activity
H1A11_RS12390	COG0739	heme binding
H1A11_RS12395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1A11_RS12400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H1A11_RS12420	COG0811	peptide transport
H1A11_RS12430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H1A11_RS12445	COG4771	TonB-dependent receptor
H1A11_RS12450	COG0702	epimerase
H1A11_RS12455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1A11_RS12465	COG3458	cephalosporin-C deacetylase activity
H1A11_RS12470	COG4948	Mandelate Racemase Muconate Lactonizing
H1A11_RS12475	COG3250	beta-galactosidase activity
H1A11_RS12505	COG4771	TonB-dependent receptor
H1A11_RS12515	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1A11_RS12530	COG0039	L-malate dehydrogenase activity
H1A11_RS12565	COG3118	belongs to the thioredoxin family
H1A11_RS12570	COG0673	inositol 2-dehydrogenase activity
H1A11_RS12585	COG0489	protein tyrosine kinase activity
H1A11_RS12590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H1A11_RS12595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1A11_RS12605	COG1570	exodeoxyribonuclease VII activity
H1A11_RS12615	COG0482	sulfurtransferase activity
H1A11_RS12635	COG3507	Belongs to the glycosyl hydrolase 43 family
H1A11_RS12650	COG3940	Belongs to the glycosyl hydrolase 43 family
H1A11_RS12655	COG3250	beta-galactosidase activity
H1A11_RS12680	COG1629	transport
H1A11_RS12680	COG4206	TonB-dependent receptor
H1A11_RS12700	COG3292	Two component regulator propeller
H1A11_RS12700	COG0745	RESPONSE REGULATOR receiver
H1A11_RS12700	COG2205	protein histidine kinase activity
H1A11_RS12735	COG0673	inositol 2-dehydrogenase activity
H1A11_RS12745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H1A11_RS12750	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1A11_RS12755	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H1A11_RS12765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H1A11_RS12770	COG0052	Belongs to the universal ribosomal protein uS2 family
H1A11_RS12775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H1A11_RS12780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H1A11_RS12790	COG0017	Asparaginyl-tRNA synthetase
H1A11_RS12795	COG1187	pseudouridine synthase activity
H1A11_RS12815	COG0110	maltose O-acetyltransferase activity
H1A11_RS12820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H1A11_RS12840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H1A11_RS12855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1A11_RS12865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1A11_RS12870	COG0516	GMP reductase activity
H1A11_RS12870	COG0517	IMP dehydrogenase activity
H1A11_RS12875	COG0514	ATP-dependent DNA helicase (RecQ)
H1A11_RS12880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H1A11_RS12885	COG0740	serine-type endopeptidase activity
H1A11_RS12890	COG0544	peptidyl-prolyl cis-trans isomerase activity
H1A11_RS12895	COG0724	RNA recognition motif
H1A11_RS12905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1A11_RS12910	COG1127	ABC transporter
H1A11_RS12915	COG1160	GTP binding
H1A11_RS12920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H1A11_RS12925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H1A11_RS12975	COG4771	TonB-dependent receptor
H1A11_RS12980	COG0702	epimerase
H1A11_RS13005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H1A11_RS13010	COG2202	Pas domain
H1A11_RS13010	COG2205	protein histidine kinase activity
H1A11_RS13015	COG2202	Pas domain
H1A11_RS13015	COG2205	protein histidine kinase activity
H1A11_RS13025	COG0436	Aminotransferase
H1A11_RS13030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1A11_RS13075	COG2755	lipolytic protein G-D-S-L family
H1A11_RS13080	COG3537	Alpha-1,2-mannosidase
H1A11_RS13085	COG3537	Alpha-1,2-mannosidase
H1A11_RS13105	COG2017	converts alpha-aldose to the beta-anomer
H1A11_RS13110	COG1501	Belongs to the glycosyl hydrolase 31 family
H1A11_RS13120	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1A11_RS13125	COG1082	Xylose isomerase domain protein TIM barrel
H1A11_RS13150	COG4771	TonB-dependent receptor
H1A11_RS13160	COG4948	Mandelate Racemase Muconate Lactonizing
H1A11_RS13165	COG0457	Tetratricopeptide repeat
H1A11_RS13170	COG2814	Major facilitator Superfamily
H1A11_RS13170	COG0477	Major facilitator Superfamily
H1A11_RS13175	COG4977	sequence-specific DNA binding
H1A11_RS13175	COG1917	Cupin 2, conserved barrel domain protein
H1A11_RS13195	COG2207	Transcriptional regulator
H1A11_RS13195	COG4753	response regulator
H1A11_RS13200	COG5002	protein histidine kinase activity
H1A11_RS13205	COG2205	protein histidine kinase activity
H1A11_RS13215	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H1A11_RS13220	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H1A11_RS13225	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H1A11_RS13235	COG2204	response regulator
H1A11_RS13240	COG0527	aspartate kinase activity
H1A11_RS13240	COG0460	homoserine dehydrogenase
H1A11_RS13250	COG2942	2-epimerase
H1A11_RS13255	COG2211	Major facilitator Superfamily
H1A11_RS13260	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H1A11_RS13265	COG4124	Belongs to the glycosyl hydrolase 26 family
H1A11_RS13325	COG4206	TonB-dependent receptor
H1A11_RS13325	COG1629	transport
H1A11_RS13330	COG4124	Belongs to the glycosyl hydrolase 26 family
H1A11_RS13345	COG0561	phosphatase activity
H1A11_RS13350	COG4771	TonB-dependent receptor
H1A11_RS13355	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H1A11_RS13365	COG3458	cephalosporin-C deacetylase activity
H1A11_RS13370	COG2207	Transcriptional regulator
H1A11_RS13370	COG0662	Cupin 2, conserved barrel domain protein
H1A11_RS13375	COG3250	beta-galactosidase activity
H1A11_RS13380	COG3459	Glycosyltransferase 36 associated
H1A11_RS13385	COG0667	Aldo Keto reductase
H1A11_RS13390	COG4948	Mandelate Racemase Muconate Lactonizing
H1A11_RS13405	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS13410	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS13415	COG0737	Belongs to the 5'-nucleotidase family
H1A11_RS13420	COG0737	Belongs to the 5'-nucleotidase family
H1A11_RS13425	COG0335	large ribosomal subunit rRNA binding
H1A11_RS13430	COG1940	carbohydrate kinase activity
H1A11_RS13435	COG1136	(ABC) transporter
H1A11_RS13440	COG0577	efflux transmembrane transporter activity
H1A11_RS13440	COG1136	(ABC) transporter
H1A11_RS13445	COG0577	efflux transmembrane transporter activity
H1A11_RS13445	COG1136	(ABC) transporter
H1A11_RS13450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1A11_RS13470	COG2996	Protein conserved in bacteria
H1A11_RS13475	COG0039	L-malate dehydrogenase activity
H1A11_RS13500	COG0137	argininosuccinate synthase activity
H1A11_RS13510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H1A11_RS13515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1A11_RS13520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H1A11_RS13525	COG1917	Cupin 2, conserved barrel domain protein
H1A11_RS13525	COG1396	sequence-specific DNA binding
H1A11_RS13530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1A11_RS13550	COG0165	Argininosuccinate lyase
H1A11_RS13560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H1A11_RS13570	COG2890	protein-(glutamine-N5) methyltransferase activity
H1A11_RS13575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1A11_RS13575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1A11_RS13585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H1A11_RS13605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H1A11_RS13615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H1A11_RS13620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H1A11_RS13650	COG0564	pseudouridine synthase activity
H1A11_RS13660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H1A11_RS13665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H1A11_RS13670	COG1216	Glycosyl transferase, family 2
H1A11_RS13675	COG2003	Belongs to the UPF0758 family
H1A11_RS13685	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1A11_RS13700	COG1785	Belongs to the alkaline phosphatase family
H1A11_RS13705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H1A11_RS13710	COG0280	phosphate acetyltransferase
H1A11_RS13715	COG1380	Effector of murein hydrolase LrgA
H1A11_RS13720	COG1346	cytolysis
H1A11_RS13735	COG0312	modulator of DNA gyrase
H1A11_RS13740	COG0312	modulator of DNA gyrase
H1A11_RS13745	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H1A11_RS13750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1A11_RS13755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1A11_RS13765	COG0733	neurotransmitter:sodium symporter activity
H1A11_RS13775	COG1136	(ABC) transporter
H1A11_RS13780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H1A11_RS13785	COG0475	glutathione-regulated potassium exporter activity
H1A11_RS13785	COG0589	response to stress
H1A11_RS13790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H1A11_RS13795	COG0702	epimerase
H1A11_RS13800	COG4206	TonB-dependent receptor
H1A11_RS13800	COG1629	transport
H1A11_RS13810	COG1629	transport
H1A11_RS13810	COG4206	TonB-dependent receptor
H1A11_RS13815	COG0702	epimerase
H1A11_RS13845	COG3876	Protein conserved in bacteria
H1A11_RS13850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1A11_RS13880	COG2807	transmembrane transport
H1A11_RS13885	COG3876	Protein conserved in bacteria
H1A11_RS13905	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H1A11_RS13910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1A11_RS13920	COG0423	glycine-tRNA ligase activity
H1A11_RS13925	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS13930	COG2382	esterase
H1A11_RS13940	COG0702	epimerase
H1A11_RS13945	COG4771	TonB-dependent receptor
H1A11_RS13960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1A11_RS13965	COG3958	Transketolase
H1A11_RS13970	COG3959	Transketolase, thiamine diphosphate binding domain
H1A11_RS13975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1A11_RS13975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H1A11_RS13980	COG1349	DNA-binding transcription factor activity
H1A11_RS13985	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H1A11_RS13995	COG3250	beta-galactosidase activity
H1A11_RS14000	COG0745	RESPONSE REGULATOR receiver
H1A11_RS14000	COG2205	protein histidine kinase activity
H1A11_RS14000	COG3292	Two component regulator propeller
H1A11_RS14005	COG4771	TonB-dependent receptor
H1A11_RS14010	COG0561	phosphatase activity
H1A11_RS14025	COG4948	Mandelate Racemase Muconate Lactonizing
H1A11_RS14030	COG3250	beta-galactosidase activity
H1A11_RS14035	COG1874	Beta-galactosidase
H1A11_RS14040	COG3250	beta-galactosidase activity
H1A11_RS14050	COG1501	Belongs to the glycosyl hydrolase 31 family
H1A11_RS14055	COG3507	Belongs to the glycosyl hydrolase 43 family
H1A11_RS14085	COG4206	TonB-dependent receptor
H1A11_RS14085	COG1629	transport
H1A11_RS14110	COG4771	TonB-dependent receptor
H1A11_RS14115	COG0702	epimerase
H1A11_RS14120	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS14145	COG2954	triphosphatase activity
H1A11_RS14150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H1A11_RS14185	COG4771	TonB-dependent receptor
H1A11_RS14190	COG1022	Amp-dependent synthetase and ligase
H1A11_RS14195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1A11_RS14200	COG4942	peptidase
H1A11_RS14215	COG0756	dUTP diphosphatase activity
H1A11_RS14255	COG2001	Belongs to the MraZ family
H1A11_RS14270	COG0768	penicillin binding
H1A11_RS14275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1A11_RS14280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H1A11_RS14285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H1A11_RS14290	COG0772	Belongs to the SEDS family
H1A11_RS14295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H1A11_RS14300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1A11_RS14310	COG0849	cell division
H1A11_RS14315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1A11_RS14320	COG1610	YqeY-like protein
H1A11_RS14325	COG1381	Involved in DNA repair and RecF pathway recombination
H1A11_RS14335	COG0268	Binds directly to 16S ribosomal RNA
H1A11_RS14340	COG0187	DNA topoisomerase II activity
H1A11_RS14350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H1A11_RS14360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H1A11_RS14370	COG4206	TonB-dependent receptor
H1A11_RS14370	COG1629	transport
H1A11_RS14385	COG2431	L-lysine efflux transmembrane transporter activity
H1A11_RS14390	COG3250	beta-galactosidase activity
H1A11_RS14395	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H1A11_RS14395	COG3408	Glycogen debranching enzyme
H1A11_RS14400	COG3426	butyrate kinase activity
H1A11_RS14405	COG0280	phosphate acetyltransferase
H1A11_RS14420	COG2166	iron-sulfur cluster assembly
H1A11_RS14425	COG3655	Transcriptional regulator
H1A11_RS14445	COG1266	CAAX protease self-immunity
H1A11_RS14455	COG0196	riboflavin kinase activity
H1A11_RS14460	COG1011	Hydrolase
H1A11_RS14465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H1A11_RS14475	COG1773	rubredoxin
H1A11_RS14480	COG1283	sodium-dependent phosphate transmembrane transporter activity
H1A11_RS14495	COG0006	proline dipeptidase activity
H1A11_RS14510	COG0509	glycine decarboxylation via glycine cleavage system
H1A11_RS14515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H1A11_RS14520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H1A11_RS14525	COG2066	Belongs to the glutaminase family
H1A11_RS14550	COG3119	arylsulfatase activity
H1A11_RS14575	COG0702	epimerase
H1A11_RS14580	COG4771	TonB-dependent receptor
H1A11_RS14600	COG0793	Belongs to the peptidase S41A family
H1A11_RS14605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1A11_RS14625	COG1040	competence protein
H1A11_RS14640	COG1357	PFAM Pentapeptide repeats (8 copies)
H1A11_RS14640	COG0515	serine threonine protein kinase
H1A11_RS14670	COG2815	serine threonine protein kinase
H1A11_RS14670	COG0515	serine threonine protein kinase
H1A11_RS14675	COG0515	serine threonine protein kinase
H1A11_RS14675	COG2815	serine threonine protein kinase
H1A11_RS14680	COG0515	serine threonine protein kinase
H1A11_RS14685	COG2801	Transposase and inactivated derivatives
H1A11_RS14690	COG2815	serine threonine protein kinase
H1A11_RS14690	COG0515	serine threonine protein kinase
H1A11_RS14730	COG0631	protein serine/threonine phosphatase activity
H1A11_RS14740	COG2176	DNA-directed DNA polymerase activity
H1A11_RS14765	COG0018	arginyl-trna synthetase
H1A11_RS14785	COG0708	Exodeoxyribonuclease III
H1A11_RS14790	COG0339	signal peptide processing
H1A11_RS14795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1A11_RS14805	COG0674	pyruvate-flavodoxin oxidoreductase activity
H1A11_RS14805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H1A11_RS14810	COG1013	pyruvate-flavodoxin oxidoreductase activity
H1A11_RS14815	COG4206	TonB-dependent receptor
H1A11_RS14815	COG1629	transport
H1A11_RS14845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H1A11_RS14850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H1A11_RS14865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H1A11_RS14890	COG0318	PFAM AMP-dependent synthetase and ligase
H1A11_RS14895	COG1854	S-ribosylhomocysteine lyase activity
H1A11_RS14900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1A11_RS14910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H1A11_RS14915	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1A11_RS14930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H1A11_RS14935	COG4974	Belongs to the 'phage' integrase family
H1A11_RS14950	COG0606	chelatase, subunit chli
H1A11_RS14960	COG3594	Acyltransferase
H1A11_RS14970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1A11_RS14970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1A11_RS14985	COG3475	LICD family
H1A11_RS14995	COG0438	transferase activity, transferring glycosyl groups
H1A11_RS15005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H1A11_RS15010	COG0545	Peptidyl-prolyl cis-trans isomerase
H1A11_RS15015	COG0545	Peptidyl-prolyl cis-trans isomerase
H1A11_RS15020	COG1522	sequence-specific DNA binding
H1A11_RS15070	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H1A11_RS15120	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H1A11_RS15120	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H1A11_RS15160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H1A11_RS15165	COG3409	Peptidoglycan-binding domain 1 protein
H1A11_RS15165	COG0793	Belongs to the peptidase S41A family
H1A11_RS15170	COG0671	phosphoesterase, PA-phosphatase related
H1A11_RS15185	COG1053	succinate dehydrogenase
H1A11_RS15190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1A11_RS15230	COG0826	peptidase U32
H1A11_RS15235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1A11_RS15255	COG0557	exoribonuclease II activity
H1A11_RS15270	COG1045	serine acetyltransferase
H1A11_RS15275	COG0116	Belongs to the methyltransferase superfamily
H1A11_RS15275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H1A11_RS15280	COG1506	peptidase
H1A11_RS15280	COG0823	Involved in the tonB-independent uptake of proteins
H1A11_RS15285	COG0151	Belongs to the GarS family
H1A11_RS15295	COG1238	metal cluster binding
H1A11_RS15325	COG2942	2-epimerase
H1A11_RS15335	COG1629	transport
H1A11_RS15335	COG4206	TonB-dependent receptor
H1A11_RS15340	COG1501	Belongs to the glycosyl hydrolase 31 family
H1A11_RS15345	COG3292	Two component regulator propeller
H1A11_RS15345	COG2205	protein histidine kinase activity
H1A11_RS15345	COG0745	RESPONSE REGULATOR receiver
H1A11_RS15350	COG3291	Pkd domain containing protein
H1A11_RS15360	COG2942	2-epimerase
H1A11_RS15375	COG2076	Multidrug Resistance protein
H1A11_RS15385	COG3328	transposase activity
H1A11_RS15395	COG1373	ATPase (AAA superfamily
H1A11_RS15415	COG4585	Histidine kinase
H1A11_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
H1A11_RS15435	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H1A11_RS15445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H1A11_RS15450	COG0084	hydrolase, TatD family'
H1A11_RS15455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H1A11_RS15460	COG0594	ribonuclease P activity
H1A11_RS15475	COG1611	Belongs to the LOG family
H1A11_RS15485	COG2205	protein histidine kinase activity
H1A11_RS15535	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1A11_RS15570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H1A11_RS15575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1A11_RS15575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H1A11_RS15580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H1A11_RS15585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H1A11_RS15590	COG1968	undecaprenyl-diphosphatase activity
H1A11_RS15600	COG2177	Part of the ABC transporter FtsEX involved in
H1A11_RS15605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H1A11_RS15615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H1A11_RS15625	COG0427	acetyl-CoA hydrolase
H1A11_RS15695	COG3279	Response regulator of the LytR AlgR family
H1A11_RS15710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H1A11_RS15715	COG1592	Rubrerythrin
H1A11_RS15720	COG0659	secondary active sulfate transmembrane transporter activity
H1A11_RS15735	COG0731	radical SAM domain protein
H1A11_RS15735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H1A11_RS15745	COG1476	TRANSCRIPTIONal
H1A11_RS15765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H1A11_RS15770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1A11_RS15775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1A11_RS15780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H1A11_RS15785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H1A11_RS15790	COG0495	leucyl-tRNA aminoacylation
H1A11_RS15795	COG0697	spore germination
H1A11_RS15820	COG3537	Alpha-1,2-mannosidase
H1A11_RS15835	COG3537	Alpha-1,2-mannosidase
H1A11_RS15850	COG0561	phosphatase activity
H1A11_RS15855	COG1629	transport
H1A11_RS15860	COG2207	Transcriptional regulator
H1A11_RS15860	COG3708	Transcriptional regulator
H1A11_RS15880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H1A11_RS15885	COG3250	beta-galactosidase activity
H1A11_RS15890	COG0745	RESPONSE REGULATOR receiver
H1A11_RS15890	COG3292	Two component regulator propeller
H1A11_RS15890	COG2205	protein histidine kinase activity
H1A11_RS15895	COG4948	Mandelate Racemase Muconate Lactonizing
H1A11_RS15920	COG1629	transport
H1A11_RS15920	COG4206	TonB-dependent receptor
H1A11_RS15925	COG0702	epimerase
H1A11_RS15945	COG3408	Glycogen debranching enzyme
H1A11_RS15950	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS15955	COG1501	Belongs to the glycosyl hydrolase 31 family
H1A11_RS15960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H1A11_RS15975	COG0012	GTP binding
H1A11_RS15995	COG1629	transport
H1A11_RS16010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H1A11_RS16010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H1A11_RS16020	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H1A11_RS16025	COG1694	Mazg nucleotide pyrophosphohydrolase
H1A11_RS16030	COG1490	D-aminoacyl-tRNA deacylase activity
H1A11_RS16035	COG0322	excinuclease ABC activity
H1A11_RS16040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H1A11_RS16060	COG0745	RESPONSE REGULATOR receiver
H1A11_RS16060	COG2205	protein histidine kinase activity
H1A11_RS16060	COG3292	Two component regulator propeller
H1A11_RS16060	COG0745	RESPONSE REGULATOR receiver
H1A11_RS16060	COG3292	Two component regulator propeller
H1A11_RS16060	COG2205	protein histidine kinase activity
H1A11_RS16065	COG1629	transport
H1A11_RS16110	COG3408	Glycogen debranching enzyme
H1A11_RS16120	COG2017	converts alpha-aldose to the beta-anomer
H1A11_RS16130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H1A11_RS16135	COG2715	membrane protein required for spore maturation
H1A11_RS16140	COG2234	aminopeptidase activity
H1A11_RS16150	COG2255	four-way junction helicase activity
H1A11_RS16165	COG3591	Belongs to the peptidase S1B family
H1A11_RS16170	COG3634	alkyl hydroperoxide reductase activity
H1A11_RS16180	COG0583	DNA-binding transcription factor activity
H1A11_RS16185	COG0783	Belongs to the Dps family
H1A11_RS16200	COG4176	ABC-type proline glycine betaine transport system permease component
H1A11_RS16205	COG2113	Glycine betaine
H1A11_RS16250	COG0513	Belongs to the DEAD box helicase family
H1A11_RS16260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1A11_RS16265	COG0517	IMP dehydrogenase activity
H1A11_RS16265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1A11_RS16270	COG0612	Peptidase, M16
H1A11_RS16280	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1A11_RS16295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H1A11_RS16300	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS16305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H1A11_RS16310	COG1312	Catalyzes the dehydration of D-mannonate
H1A11_RS16315	COG1028	Short-chain dehydrogenase reductase Sdr
H1A11_RS16325	COG0681	Belongs to the peptidase S26 family
H1A11_RS16330	COG0681	Belongs to the peptidase S26 family
H1A11_RS16335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H1A11_RS16355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1A11_RS16360	COG5492	domain, Protein
H1A11_RS16370	COG0702	epimerase
H1A11_RS16375	COG4771	TonB-dependent receptor
H1A11_RS16380	COG3119	arylsulfatase activity
H1A11_RS16385	COG2205	protein histidine kinase activity
H1A11_RS16385	COG0745	RESPONSE REGULATOR receiver
H1A11_RS16385	COG3292	Two component regulator propeller
H1A11_RS16385	COG2205	protein histidine kinase activity
H1A11_RS16385	COG0745	RESPONSE REGULATOR receiver
H1A11_RS16385	COG3292	Two component regulator propeller
H1A11_RS16400	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H1A11_RS16415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1A11_RS16435	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1A11_RS16440	COG3119	arylsulfatase activity
H1A11_RS16455	COG0482	sulfurtransferase activity
H1A11_RS16465	COG0205	6-phosphofructokinase activity
H1A11_RS16470	COG0571	ribonuclease III activity
H1A11_RS16475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1A11_RS16480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H1A11_RS16485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1A11_RS16490	COG3083	sulfuric ester hydrolase activity
H1A11_RS16495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1A11_RS16505	COG0438	transferase activity, transferring glycosyl groups
H1A11_RS16510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1A11_RS16515	COG4750	Nucleotidyl transferase
H1A11_RS16520	COG3475	LICD family
H1A11_RS16535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H1A11_RS16535	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H1A11_RS16540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H1A11_RS16545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H1A11_RS16555	COG1368	sulfuric ester hydrolase activity
H1A11_RS16565	COG1216	Glycosyl transferase, family 2
H1A11_RS16565	COG1442	glycosyl transferase family 8
H1A11_RS16570	COG1215	transferase activity, transferring glycosyl groups
H1A11_RS16575	COG1215	transferase activity, transferring glycosyl groups
H1A11_RS16590	COG1132	(ABC) transporter
H1A11_RS16595	COG1132	(ABC) transporter
H1A11_RS16605	COG0673	inositol 2-dehydrogenase activity
H1A11_RS16620	COG3341	Caulimovirus viroplasmin
H1A11_RS16620	COG0328	RNA-DNA hybrid ribonuclease activity
H1A11_RS16630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H1A11_RS16635	COG1166	arginine decarboxylase activity
H1A11_RS16640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H1A11_RS16645	COG1595	DNA-templated transcription, initiation
H1A11_RS16670	COG2205	protein histidine kinase activity
H1A11_RS16670	COG0745	RESPONSE REGULATOR receiver
H1A11_RS16670	COG3292	Two component regulator propeller
H1A11_RS16675	COG2272	Belongs to the type-B carboxylesterase lipase family
H1A11_RS16680	COG1629	transport
H1A11_RS16685	COG0561	phosphatase activity
H1A11_RS16690	COG3507	Belongs to the glycosyl hydrolase 43 family
H1A11_RS16690	COG3693	PFAM glycoside hydrolase, family 10
H1A11_RS16690	COG2382	esterase
H1A11_RS16695	COG2382	esterase
H1A11_RS16700	COG2382	esterase
H1A11_RS16705	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS16710	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS16715	COG0779	Required for maturation of 30S ribosomal subunits
H1A11_RS16720	COG0195	Participates in both transcription termination and antitermination
H1A11_RS16725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H1A11_RS16735	COG0719	Fe-S assembly protein
H1A11_RS16740	COG0396	ATPase activity
H1A11_RS16745	COG0719	Fe-S assembly protein
H1A11_RS16750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1A11_RS16755	COG0393	Putative heavy-metal-binding
H1A11_RS16760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H1A11_RS16770	COG4206	TonB-dependent receptor
H1A11_RS16770	COG1629	transport
H1A11_RS16785	COG1185	polyribonucleotide nucleotidyltransferase activity
H1A11_RS16795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1A11_RS16800	COG0537	adenosine 5'-monophosphoramidase activity
H1A11_RS16805	COG0662	Cupin 2, conserved barrel domain protein
H1A11_RS16805	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H1A11_RS16855	COG4804	nuclease activity
H1A11_RS16885	COG4771	TonB-dependent receptor
H1A11_RS16905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H1A11_RS16910	COG3292	Two component regulator propeller
H1A11_RS16910	COG0745	RESPONSE REGULATOR receiver
H1A11_RS16910	COG2205	protein histidine kinase activity
H1A11_RS16915	COG1501	Belongs to the glycosyl hydrolase 31 family
H1A11_RS16920	COG3250	beta-galactosidase activity
H1A11_RS16925	COG1472	Belongs to the glycosyl hydrolase 3 family
H1A11_RS16945	COG2096	Adenosyltransferase
H1A11_RS16955	COG0514	ATP-dependent DNA helicase (RecQ)
H1A11_RS17050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H1A11_RS17055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1A11_RS17085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1A11_RS17095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1A11_RS17100	COG0006	proline dipeptidase activity
H1A11_RS17105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H1A11_RS17110	COG4974	Belongs to the 'phage' integrase family
H1A11_RS17155	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H1A11_RS17160	COG0081	regulation of translation
H1A11_RS17165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H1A11_RS17170	COG0222	ribosome binding
H1A11_RS17175	COG0085	RNA polymerase activity
H1A11_RS17180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H1A11_RS17190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H1A11_RS17195	COG0049	tRNA binding
H1A11_RS17200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H1A11_RS17205	COG0051	transcription antitermination factor activity, RNA binding
H1A11_RS17210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H1A11_RS17215	COG0088	Forms part of the polypeptide exit tunnel
H1A11_RS17220	COG0089	rRNA binding
H1A11_RS17225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H1A11_RS17230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H1A11_RS17235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H1A11_RS17240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H1A11_RS17245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H1A11_RS17250	COG0255	Belongs to the universal ribosomal protein uL29 family
H1A11_RS17255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H1A11_RS17260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H1A11_RS17265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H1A11_RS17270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H1A11_RS17275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H1A11_RS17280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H1A11_RS17285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H1A11_RS17290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H1A11_RS17295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H1A11_RS17300	COG1841	ribosomal large subunit assembly
H1A11_RS17305	COG0200	Binds to the 23S rRNA
H1A11_RS17320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H1A11_RS17325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H1A11_RS17330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H1A11_RS17335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H1A11_RS17340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H1A11_RS17345	COG0202	RNA polymerase activity
H1A11_RS17350	COG0203	ribosomal protein L17
H1A11_RS17365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H1A11_RS17380	COG2431	L-lysine efflux transmembrane transporter activity
H1A11_RS17395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H1A11_RS17405	COG1228	amidohydrolase
H1A11_RS17415	COG2986	histidine ammonia-lyase
H1A11_RS17420	COG1309	transcriptional regulator
H1A11_RS17430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1A11_RS17455	COG1696	Membrane protein involved in D-alanine export
H1A11_RS17460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H1A11_RS17540	COG1132	(ABC) transporter
H1A11_RS17560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1A11_RS17635	COG4206	TonB-dependent receptor
H1A11_RS17635	COG1629	transport
H1A11_RS17705	COG4771	TonB-dependent receptor
H1A11_RS17725	COG3507	Belongs to the glycosyl hydrolase 43 family
H1A11_RS17730	COG2205	protein histidine kinase activity
H1A11_RS17730	COG3292	Two component regulator propeller
H1A11_RS17730	COG0745	RESPONSE REGULATOR receiver
H1A11_RS17765	COG0776	regulation of translation
H1A11_RS17805	COG0562	UDP-galactopyranose mutase
H1A11_RS17810	COG0463	Glycosyl transferase, family 2
H1A11_RS17820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H1A11_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
H1A11_RS17835	COG0726	polysaccharide deacetylase
H1A11_RS17840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1A11_RS17845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H1A11_RS17855	COG2801	Transposase and inactivated derivatives
H1A11_RS17880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H1A11_RS17990	COG1131	(ABC) transporter
H1A11_RS18010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H1A11_RS18030	COG0564	pseudouridine synthase activity
H1A11_RS18035	COG0823	Involved in the tonB-independent uptake of proteins
H1A11_RS18035	COG1506	peptidase
H1A11_RS18045	COG2204	response regulator
H1A11_RS18050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H1A11_RS18055	COG0612	Peptidase, M16
H1A11_RS18060	COG0534	Mate efflux family protein
H1A11_RS18065	COG5002	protein histidine kinase activity
H1A11_RS18065	COG2198	Histidine kinase
H1A11_RS18065	COG0784	Response regulator, receiver
H1A11_RS18100	COG2205	protein histidine kinase activity
H1A11_RS18100	COG0784	Response regulator, receiver
H1A11_RS18105	COG0488	(ABC) transporter
H1A11_RS18110	COG3590	peptidase
H1A11_RS18115	COG0138	bifunctional purine biosynthesis protein purh
H1A11_RS18125	COG1792	Involved in formation and maintenance of cell shape
H1A11_RS18140	COG0772	Belongs to the SEDS family
H1A11_RS18150	COG1774	PSP1 C-terminal conserved region
H1A11_RS18155	COG0470	DNA polymerase III
H1A11_RS18160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H1A11_RS18175	COG0826	peptidase U32
H1A11_RS18185	COG4771	TonB-dependent receptor
H1A11_RS18195	COG3292	Two component regulator propeller
H1A11_RS18195	COG2205	protein histidine kinase activity
H1A11_RS18195	COG2205	protein histidine kinase activity
H1A11_RS18195	COG0745	RESPONSE REGULATOR receiver
H1A11_RS18195	COG0745	RESPONSE REGULATOR receiver
H1A11_RS18195	COG3292	Two component regulator propeller
H1A11_RS18200	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H1A11_RS18205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H1A11_RS18210	COG0288	reversible hydration of carbon dioxide
H1A11_RS18215	COG0252	asparaginase activity
H1A11_RS18220	COG0527	aspartate kinase activity
H1A11_RS18220	COG0460	homoserine dehydrogenase
H1A11_RS18225	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
H1A11_RS18230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H1A11_RS18305	COG0628	permease
H1A11_RS18310	COG1435	thymidine kinase activity
H1A11_RS18320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H1A11_RS18335	COG2095	MarC family integral membrane protein
H1A11_RS18345	COG1629	transport
H1A11_RS18345	COG4206	TonB-dependent receptor
H1A11_RS18360	COG1629	transport
H1A11_RS18370	COG1629	transport
H1A11_RS18370	COG4206	TonB-dependent receptor
H1A11_RS18385	COG1373	ATPase (AAA superfamily
H1A11_RS18390	COG4206	TonB-dependent receptor
H1A11_RS18390	COG1629	transport
H1A11_RS18400	COG4206	TonB-dependent receptor
H1A11_RS18400	COG1629	transport
H1A11_RS18415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1A11_RS18425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1A11_RS18425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1A11_RS18450	COG1162	GTPase activity
H1A11_RS18505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H1A11_RS18510	COG0006	proline dipeptidase activity
H1A11_RS18515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1A11_RS18525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H1A11_RS18565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H1A11_RS18570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1A11_RS18730	COG1629	transport
H1A11_RS18730	COG4206	TonB-dependent receptor
H1A11_RS18750	COG4974	Belongs to the 'phage' integrase family
H1A11_RS18755	COG4206	TonB-dependent receptor
H1A11_RS18755	COG1629	transport
H1A11_RS18765	COG2095	MarC family integral membrane protein
H1A11_RS18800	COG1373	ATPase (AAA superfamily
H1A11_RS18815	COG4206	TonB-dependent receptor
H1A11_RS18815	COG1629	transport
H1A11_RS18820	COG4974	Belongs to the 'phage' integrase family