locus-tag	class	description
I6J55_RS00015	COG0438	transferase activity, transferring glycosyl groups
I6J55_RS00020	COG1045	serine acetyltransferase
I6J55_RS00030	COG1216	Glycosyl transferase, family 2
I6J55_RS00050	COG1215	transferase activity, transferring glycosyl groups
I6J55_RS00055	COG1216	Glycosyl transferase, family 2
I6J55_RS00060	COG1216	Glycosyl transferase, family 2
I6J55_RS00110	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J55_RS00145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J55_RS00165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J55_RS00175	COG0573	inorganic phosphate transmembrane transporter activity
I6J55_RS00180	COG0581	inorganic phosphate transmembrane transporter activity
I6J55_RS00185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J55_RS00190	COG0704	Plays a role in the regulation of phosphate uptake
I6J55_RS00200	COG0778	Nitroreductase
I6J55_RS00205	COG1295	ribonuclease BN
I6J55_RS00220	COG4948	Mandelate Racemase Muconate Lactonizing
I6J55_RS00230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J55_RS00235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J55_RS00260	COG5002	protein histidine kinase activity
I6J55_RS00265	COG0745	RESPONSE REGULATOR receiver
I6J55_RS00315	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I6J55_RS00335	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J55_RS00345	COG0058	SHG alpha-glucan phosphorylase activity
I6J55_RS00355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J55_RS00365	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J55_RS00370	COG1177	transmembrane transport
I6J55_RS00380	COG0724	RNA recognition motif
I6J55_RS00395	COG0228	four-way junction DNA binding
I6J55_RS00415	COG1690	Belongs to the RtcB family
I6J55_RS00420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J55_RS00435	COG2198	Histidine kinase
I6J55_RS00435	COG0784	Response regulator, receiver
I6J55_RS00435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J55_RS00435	COG2205	protein histidine kinase activity
I6J55_RS00440	COG1733	regulation of RNA biosynthetic process
I6J55_RS00450	COG1609	Transcriptional regulator
I6J55_RS00465	COG3610	response to peptide
I6J55_RS00470	COG2966	Psort location CytoplasmicMembrane, score
I6J55_RS00480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J55_RS00485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J55_RS00510	COG4771	TonB-dependent receptor
I6J55_RS00545	COG1566	PFAM secretion protein HlyD family protein
I6J55_RS00550	COG2814	Major facilitator Superfamily
I6J55_RS00565	COG4771	TonB-dependent receptor
I6J55_RS00575	COG1858	cytochrome C peroxidase
I6J55_RS00600	COG0716	FMN binding
I6J55_RS00605	COG0138	bifunctional purine biosynthesis protein purh
I6J55_RS00615	COG2197	response regulator
I6J55_RS00620	COG0110	maltose O-acetyltransferase activity
I6J55_RS00630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J55_RS00645	COG0252	asparaginase activity
I6J55_RS00650	COG0159	tryptophan synthase activity
I6J55_RS00655	COG0135	phosphoribosylanthranilate isomerase activity
I6J55_RS00660	COG0134	indole-3-glycerol-phosphate synthase activity
I6J55_RS00670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J55_RS00670	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J55_RS00675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J55_RS00680	COG0133	tryptophan synthase activity
I6J55_RS00685	COG1979	alcohol dehydrogenase
I6J55_RS00695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J55_RS00705	COG0436	Aminotransferase
I6J55_RS00730	COG0367	asparagine synthase
I6J55_RS00740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J55_RS00750	COG0505	Belongs to the CarA family
I6J55_RS00755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J55_RS00785	COG1131	(ABC) transporter
I6J55_RS00790	COG0842	Transport permease protein
I6J55_RS00800	COG0784	Response regulator, receiver
I6J55_RS00800	COG2205	protein histidine kinase activity
I6J55_RS00810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J55_RS00820	COG2949	membrane
I6J55_RS00825	COG0556	nucleotide-excision repair
I6J55_RS00830	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J55_RS00860	COG3942	CHAP domain
I6J55_RS00860	COG1388	LysM domain
I6J55_RS00870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J55_RS00885	COG1695	Transcriptional regulator
I6J55_RS00900	COG1506	peptidase
I6J55_RS00900	COG0823	Involved in the tonB-independent uptake of proteins
I6J55_RS00905	COG0534	Mate efflux family protein
I6J55_RS00915	COG0504	CTP synthase activity
I6J55_RS00940	COG4656	Part of a membrane complex involved in electron transport
I6J55_RS00945	COG4658	electron transport chain
I6J55_RS00950	COG4659	FMN binding
I6J55_RS00955	COG4660	Part of a membrane complex involved in electron transport
I6J55_RS00960	COG4657	Part of a membrane complex involved in electron transport
I6J55_RS00965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J55_RS00985	COG0305	Participates in initiation and elongation during chromosome replication
I6J55_RS01010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J55_RS01015	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6J55_RS01075	COG1216	Glycosyl transferase, family 2
I6J55_RS01080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS01085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J55_RS01090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J55_RS01090	COG0072	phenylalanine-tRNA ligase activity
I6J55_RS01095	COG0217	transcriptional regulatory protein
I6J55_RS01110	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J55_RS01115	COG0708	Exodeoxyribonuclease III
I6J55_RS01135	COG0481	GTPase activity
I6J55_RS01160	COG0024	Methionine aminopeptidase
I6J55_RS01195	COG1518	maintenance of DNA repeat elements
I6J55_RS01200	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6J55_RS01215	COG0564	pseudouridine synthase activity
I6J55_RS01220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J55_RS01225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J55_RS01225	COG0574	Belongs to the PEP-utilizing enzyme family
I6J55_RS01240	COG0352	thiamine-phosphate diphosphorylase activity
I6J55_RS01260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J55_RS01265	COG2022	thiamine diphosphate biosynthetic process
I6J55_RS01335	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J55_RS01350	COG0305	Participates in initiation and elongation during chromosome replication
I6J55_RS01415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J55_RS01420	COG1120	ATPase activity
I6J55_RS01445	COG1192	Involved in chromosome partitioning
I6J55_RS01455	COG1629	transport
I6J55_RS01515	COG4974	Belongs to the 'phage' integrase family
I6J55_RS01520	COG4974	Belongs to the 'phage' integrase family
I6J55_RS01625	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6J55_RS01660	COG1429	ligase activity, forming nitrogen-metal bonds
I6J55_RS01670	COG4774	siderophore transport
I6J55_RS01680	COG4771	TonB-dependent receptor
I6J55_RS01695	COG2966	Psort location CytoplasmicMembrane, score
I6J55_RS01710	COG1797	cobyrinic acid a,c-diamide synthase activity
I6J55_RS01715	COG2096	Adenosyltransferase
I6J55_RS01720	COG0784	Response regulator, receiver
I6J55_RS01720	COG2198	Histidine kinase
I6J55_RS01720	COG5002	protein histidine kinase activity
I6J55_RS01760	COG1492	cobalamin metabolic process
I6J55_RS01770	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J55_RS01780	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6J55_RS01785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J55_RS01800	COG4946	Tricorn protease homolog
I6J55_RS01800	COG0793	Belongs to the peptidase S41A family
I6J55_RS01810	COG0442	prolyl-tRNA aminoacylation
I6J55_RS01825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J55_RS01835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J55_RS01840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J55_RS01850	COG0552	protein localization to endoplasmic reticulum
I6J55_RS01855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J55_RS01865	COG1652	LysM domain
I6J55_RS01870	COG0714	Associated with various cellular activities
I6J55_RS01885	COG2304	oxidoreductase activity
I6J55_RS01930	COG0542	response to heat
I6J55_RS01965	COG2315	Protein conserved in bacteria
I6J55_RS01975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J55_RS01980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J55_RS01985	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J55_RS01990	COG0167	dihydroorotate dehydrogenase activity
I6J55_RS01995	COG0543	2 iron, 2 sulfur cluster binding
I6J55_RS02010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J55_RS02040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J55_RS02065	COG0577	efflux transmembrane transporter activity
I6J55_RS02065	COG1136	(ABC) transporter
I6J55_RS02090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J55_RS02095	COG1597	lipid kinase activity
I6J55_RS02100	COG0156	8-amino-7-oxononanoate synthase activity
I6J55_RS02110	COG1136	(ABC) transporter
I6J55_RS02110	COG0577	efflux transmembrane transporter activity
I6J55_RS02155	COG2204	response regulator
I6J55_RS02160	COG2205	protein histidine kinase activity
I6J55_RS02480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J55_RS02485	COG0343	queuine tRNA-ribosyltransferase activity
I6J55_RS02500	COG3830	Belongs to the UPF0237 family
I6J55_RS02500	COG0560	Phosphoserine phosphatase
I6J55_RS02505	COG0513	Belongs to the DEAD box helicase family
I6J55_RS02535	COG1904	glucuronate isomerase
I6J55_RS02545	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J55_RS02595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J55_RS02605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J55_RS02615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J55_RS02635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J55_RS02640	COG1858	cytochrome C peroxidase
I6J55_RS02645	COG0724	RNA recognition motif
I6J55_RS02650	COG0450	alkyl hydroperoxide reductase
I6J55_RS02655	COG3153	acetyltransferase
I6J55_RS02655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J55_RS02665	COG0477	Major facilitator Superfamily
I6J55_RS02665	COG2814	Major facilitator Superfamily
I6J55_RS02675	COG1070	Carbohydrate kinase
I6J55_RS02685	COG0351	phosphomethylpyrimidine kinase
I6J55_RS02690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J55_RS02695	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J55_RS02700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J55_RS02715	COG0671	phosphoesterase, PA-phosphatase related
I6J55_RS02735	COG2223	nitrite transmembrane transporter activity
I6J55_RS02745	COG0673	inositol 2-dehydrogenase activity
I6J55_RS02755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J55_RS02765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J55_RS02770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J55_RS02840	COG0358	DNA primase activity
I6J55_RS02845	COG0629	single-stranded DNA binding
I6J55_RS03075	COG2205	protein histidine kinase activity
I6J55_RS03080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J55_RS03100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J55_RS03110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6J55_RS03130	COG1629	transport
I6J55_RS03130	COG4206	TonB-dependent receptor
I6J55_RS03140	COG2837	iron assimilation
I6J55_RS03165	COG2431	L-lysine efflux transmembrane transporter activity
I6J55_RS03175	COG0540	Belongs to the ATCase OTCase family
I6J55_RS03180	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6J55_RS03195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J55_RS03205	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6J55_RS03210	COG2205	protein histidine kinase activity
I6J55_RS03240	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6J55_RS03245	COG1120	ATPase activity
I6J55_RS03275	COG5002	protein histidine kinase activity
I6J55_RS03280	COG0745	RESPONSE REGULATOR receiver
I6J55_RS03300	COG3118	belongs to the thioredoxin family
I6J55_RS03305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J55_RS03310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J55_RS03315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J55_RS03320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J55_RS03325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J55_RS03330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J55_RS03335	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J55_RS03345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J55_RS03355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6J55_RS03370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J55_RS03385	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J55_RS03395	COG0167	dihydroorotate dehydrogenase activity
I6J55_RS03400	COG1011	Hydrolase
I6J55_RS03420	COG0577	efflux transmembrane transporter activity
I6J55_RS03420	COG1136	(ABC) transporter
I6J55_RS03430	COG0577	efflux transmembrane transporter activity
I6J55_RS03430	COG1136	(ABC) transporter
I6J55_RS03475	COG3263	regulation of cellular component size
I6J55_RS03480	COG1022	Amp-dependent synthetase and ligase
I6J55_RS03500	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6J55_RS03510	COG1629	transport
I6J55_RS03510	COG4206	TonB-dependent receptor
I6J55_RS03520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS03535	COG0745	RESPONSE REGULATOR receiver
I6J55_RS03540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS03580	COG1475	DNA binding
I6J55_RS03585	COG3969	phosphoadenosine phosphosulfate
I6J55_RS03605	COG1522	sequence-specific DNA binding
I6J55_RS03620	COG2205	protein histidine kinase activity
I6J55_RS03625	COG1132	(ABC) transporter
I6J55_RS03640	COG1309	transcriptional regulator
I6J55_RS03665	COG4771	TonB-dependent receptor
I6J55_RS03725	COG0667	Aldo Keto reductase
I6J55_RS03730	COG2311	Membrane
I6J55_RS03735	COG4974	Belongs to the 'phage' integrase family
I6J55_RS03890	COG1475	DNA binding
I6J55_RS03905	COG1192	Involved in chromosome partitioning
I6J55_RS03950	COG0542	response to heat
I6J55_RS04045	COG3344	reverse transcriptase
I6J55_RS04065	COG0582	viral genome integration into host DNA
I6J55_RS04485	COG0484	heat shock protein binding
I6J55_RS04525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J55_RS04530	COG0756	dUTP diphosphatase activity
I6J55_RS04700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J55_RS04700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J55_RS04755	COG0587	DNA-directed DNA polymerase activity
I6J55_RS04760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J55_RS04765	COG0587	DNA-directed DNA polymerase activity
I6J55_RS04845	COG4974	Belongs to the 'phage' integrase family
I6J55_RS04875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J55_RS04880	COG3586	endonuclease activity
I6J55_RS04895	COG3645	SOS response
I6J55_RS04920	COG0582	viral genome integration into host DNA
I6J55_RS04940	COG4974	Belongs to the 'phage' integrase family
I6J55_RS04965	COG1678	Uncharacterized ACR, COG1678
I6J55_RS04980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J55_RS04990	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6J55_RS04995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J55_RS05010	COG0577	efflux transmembrane transporter activity
I6J55_RS05010	COG1136	(ABC) transporter
I6J55_RS05030	COG2204	response regulator
I6J55_RS05070	COG2217	Heavy metal translocating P-type atpase
I6J55_RS05100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J55_RS05105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J55_RS05105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J55_RS05110	COG0778	Nitroreductase
I6J55_RS05120	COG1739	Uncharacterized protein family UPF0029
I6J55_RS05125	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J55_RS05135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J55_RS05140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J55_RS05165	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6J55_RS05170	COG1805	sodium ion transport
I6J55_RS05175	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6J55_RS05205	COG1215	transferase activity, transferring glycosyl groups
I6J55_RS05220	COG1442	glycosyl transferase family 8
I6J55_RS05220	COG1216	Glycosyl transferase, family 2
I6J55_RS05225	COG2244	polysaccharide biosynthetic process
I6J55_RS05240	COG0438	transferase activity, transferring glycosyl groups
I6J55_RS05265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J55_RS05265	COG2205	protein histidine kinase activity
I6J55_RS05265	COG2198	Histidine kinase
I6J55_RS05265	COG0784	Response regulator, receiver
I6J55_RS05285	COG0488	(ABC) transporter
I6J55_RS05320	COG0156	8-amino-7-oxononanoate synthase activity
I6J55_RS05345	COG0542	response to heat
I6J55_RS05495	COG4771	TonB-dependent receptor
I6J55_RS05520	COG4771	TonB-dependent receptor
I6J55_RS05525	COG2814	Major facilitator Superfamily
I6J55_RS05530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J55_RS05535	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J55_RS05550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J55_RS05595	COG0697	spore germination
I6J55_RS05605	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J55_RS05605	COG2885	chlorophyll binding
I6J55_RS05610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J55_RS05620	COG1629	transport
I6J55_RS05620	COG4206	TonB-dependent receptor
I6J55_RS05630	COG1595	DNA-templated transcription, initiation
I6J55_RS05635	COG1704	LemA family
I6J55_RS05640	COG0501	Belongs to the peptidase M48B family
I6J55_RS05665	COG3250	beta-galactosidase activity
I6J55_RS05670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J55_RS05675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J55_RS05685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J55_RS05700	COG3831	ATPase activity
I6J55_RS05700	COG4884	unkown
I6J55_RS05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J55_RS05730	COG1136	(ABC) transporter
I6J55_RS05735	COG1136	(ABC) transporter
I6J55_RS05735	COG0577	efflux transmembrane transporter activity
I6J55_RS05745	COG3279	Response regulator of the LytR AlgR family
I6J55_RS05785	COG4413	Urea transporter
I6J55_RS05805	COG0363	glucosamine-6-phosphate deaminase activity
I6J55_RS05810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J55_RS05815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J55_RS05820	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6J55_RS05845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J55_RS05850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS05900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J55_RS05910	COG0318	PFAM AMP-dependent synthetase and ligase
I6J55_RS05925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J55_RS05930	COG1086	Polysaccharide biosynthesis protein
I6J55_RS05935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J55_RS05940	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J55_RS05950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J55_RS05985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J55_RS05990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS05995	COG0318	PFAM AMP-dependent synthetase and ligase
I6J55_RS06005	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6J55_RS06015	COG0534	Mate efflux family protein
I6J55_RS06025	COG0534	Mate efflux family protein
I6J55_RS06050	COG4771	TonB-dependent receptor
I6J55_RS06060	COG1956	GAF domain-containing protein
I6J55_RS06065	COG0737	Belongs to the 5'-nucleotidase family
I6J55_RS06070	COG2205	protein histidine kinase activity
I6J55_RS06075	COG2183	response to ionizing radiation
I6J55_RS06190	COG2885	chlorophyll binding
I6J55_RS06330	COG2183	response to ionizing radiation
I6J55_RS06335	COG2207	Transcriptional regulator
I6J55_RS06335	COG1609	Transcriptional regulator
I6J55_RS06355	COG1785	Belongs to the alkaline phosphatase family
I6J55_RS06360	COG3568	Endonuclease Exonuclease Phosphatase
I6J55_RS06365	COG3537	Alpha-1,2-mannosidase
I6J55_RS06375	COG1629	transport
I6J55_RS06375	COG4206	TonB-dependent receptor
I6J55_RS06385	COG0823	Involved in the tonB-independent uptake of proteins
I6J55_RS06410	COG1595	DNA-templated transcription, initiation
I6J55_RS06415	COG0488	(ABC) transporter
I6J55_RS06420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J55_RS06425	COG0484	heat shock protein binding
I6J55_RS06430	COG3250	beta-galactosidase activity
I6J55_RS06435	COG0702	epimerase
I6J55_RS06440	COG4206	TonB-dependent receptor
I6J55_RS06440	COG1629	transport
I6J55_RS06445	COG3250	beta-galactosidase activity
I6J55_RS06450	COG3537	Alpha-1,2-mannosidase
I6J55_RS06455	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS06465	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS06485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS06500	COG1629	transport
I6J55_RS06500	COG4206	TonB-dependent receptor
I6J55_RS06505	COG4206	TonB-dependent receptor
I6J55_RS06505	COG1629	transport
I6J55_RS06510	COG0702	epimerase
I6J55_RS06515	COG0702	epimerase
I6J55_RS06520	COG4771	TonB-dependent receptor
I6J55_RS06525	COG2731	YhcH YjgK YiaL family protein
I6J55_RS06530	COG2271	Major facilitator Superfamily
I6J55_RS06540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J55_RS06545	COG1940	carbohydrate kinase activity
I6J55_RS06595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J55_RS06610	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J55_RS06615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J55_RS06625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J55_RS06630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J55_RS06635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J55_RS06640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J55_RS06655	COG0242	peptide deformylase activity
I6J55_RS06660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J55_RS06685	COG4974	Belongs to the 'phage' integrase family
I6J55_RS06730	COG0175	sulfate reduction
I6J55_RS06735	COG0529	Catalyzes the synthesis of activated sulfate
I6J55_RS06740	COG0471	metal ion transport
I6J55_RS06740	COG3273	potassium ion transport
I6J55_RS06750	COG3250	beta-galactosidase activity
I6J55_RS06765	COG4221	oxidoreductase activity
I6J55_RS06770	COG0513	Belongs to the DEAD box helicase family
I6J55_RS06790	COG1482	cell wall glycoprotein biosynthetic process
I6J55_RS06805	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J55_RS06810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J55_RS06815	COG0698	ribose 5-phosphate isomerase
I6J55_RS06855	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6J55_RS06860	COG0673	inositol 2-dehydrogenase activity
I6J55_RS06885	COG0590	tRNA wobble adenosine to inosine editing
I6J55_RS06925	COG2264	protein methyltransferase activity
I6J55_RS06930	COG0716	FMN binding
I6J55_RS06935	COG0022	dehydrogenase e1 component
I6J55_RS06940	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J55_RS06970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J55_RS06975	COG0511	ligase activity, forming carbon-carbon bonds
I6J55_RS06980	COG0439	Biotin carboxylase
I6J55_RS06985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J55_RS06995	COG3047	cAMP biosynthetic process
I6J55_RS06995	COG2885	chlorophyll binding
I6J55_RS07000	COG1620	l-lactate permease
I6J55_RS07010	COG4771	TonB-dependent receptor
I6J55_RS07040	COG3547	Transposase (IS116 IS110 IS902 family)
I6J55_RS07045	COG1252	NADH dehydrogenase
I6J55_RS07050	COG0577	efflux transmembrane transporter activity
I6J55_RS07055	COG0577	efflux transmembrane transporter activity
I6J55_RS07055	COG1136	(ABC) transporter
I6J55_RS07060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J55_RS07075	COG3852	Histidine kinase
I6J55_RS07080	COG0628	permease
I6J55_RS07085	COG1215	transferase activity, transferring glycosyl groups
I6J55_RS07090	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J55_RS07095	COG0436	Aminotransferase
I6J55_RS07105	COG5492	domain, Protein
I6J55_RS07120	COG0488	(ABC) transporter
I6J55_RS07145	COG0745	RESPONSE REGULATOR receiver
I6J55_RS07150	COG5002	protein histidine kinase activity
I6J55_RS07165	COG4206	TonB-dependent receptor
I6J55_RS07225	COG0629	single-stranded DNA binding
I6J55_RS07230	COG3119	arylsulfatase activity
I6J55_RS07245	COG1530	ribonuclease E activity
I6J55_RS07250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J55_RS07255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS07280	COG0463	Glycosyl transferase, family 2
I6J55_RS07300	COG1442	glycosyl transferase family 8
I6J55_RS07310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS07330	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J55_RS07395	COG2204	response regulator
I6J55_RS07405	COG2205	protein histidine kinase activity
I6J55_RS07405	COG0784	Response regulator, receiver
I6J55_RS07425	COG1136	(ABC) transporter
I6J55_RS07435	COG1136	(ABC) transporter
I6J55_RS07435	COG0577	efflux transmembrane transporter activity
I6J55_RS07440	COG1136	(ABC) transporter
I6J55_RS07455	COG0577	efflux transmembrane transporter activity
I6J55_RS07455	COG1136	(ABC) transporter
I6J55_RS07465	COG0577	efflux transmembrane transporter activity
I6J55_RS07470	COG0577	efflux transmembrane transporter activity
I6J55_RS07475	COG0577	efflux transmembrane transporter activity
I6J55_RS07485	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J55_RS07485	COG1388	LysM domain
I6J55_RS07490	COG0295	cytidine deaminase activity
I6J55_RS07495	COG2207	Transcriptional regulator
I6J55_RS07495	COG1917	Cupin 2, conserved barrel domain protein
I6J55_RS07500	COG3059	membrane
I6J55_RS07505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J55_RS07510	COG0488	(ABC) transporter
I6J55_RS07525	COG3345	alpha-galactosidase
I6J55_RS07540	COG1629	transport
I6J55_RS07555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J55_RS07570	COG0686	Belongs to the AlaDH PNT family
I6J55_RS07595	COG1595	DNA-templated transcription, initiation
I6J55_RS07610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6J55_RS07620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J55_RS07650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J55_RS07665	COG1741	Belongs to the pirin family
I6J55_RS07670	COG0259	pyridoxamine-phosphate oxidase activity
I6J55_RS07685	COG0346	lactoylglutathione lyase activity
I6J55_RS07700	COG0471	metal ion transport
I6J55_RS07700	COG0490	domain, Protein
I6J55_RS07705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J55_RS07715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J55_RS07720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J55_RS07725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J55_RS07730	COG1028	Short-chain dehydrogenase reductase Sdr
I6J55_RS07760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS07780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6J55_RS07785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J55_RS07830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J55_RS07895	COG1918	ferrous iron import across plasma membrane
I6J55_RS07895	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6J55_RS07905	COG2373	Large extracellular alpha-helical protein
I6J55_RS07910	COG4953	penicillin-binding protein 1C
I6J55_RS07915	COG2814	Major facilitator Superfamily
I6J55_RS07930	COG1757	Na H antiporter
I6J55_RS07940	COG2197	response regulator
I6J55_RS07945	COG0482	sulfurtransferase activity
I6J55_RS07950	COG2873	o-acetylhomoserine
I6J55_RS07975	COG0501	Belongs to the peptidase M48B family
I6J55_RS07980	COG1253	flavin adenine dinucleotide binding
I6J55_RS08020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J55_RS08040	COG0583	DNA-binding transcription factor activity
I6J55_RS08045	COG0783	Belongs to the Dps family
I6J55_RS08050	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
I6J55_RS08080	COG4771	TonB-dependent receptor
I6J55_RS08095	COG1082	Xylose isomerase domain protein TIM barrel
I6J55_RS08110	COG4948	Mandelate Racemase Muconate Lactonizing
I6J55_RS08125	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J55_RS08130	COG1169	isochorismate synthase
I6J55_RS08135	COG0561	phosphatase activity
I6J55_RS08145	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J55_RS08160	COG1280	lysine exporter protein (LysE YggA)
I6J55_RS08165	COG4651	solute:proton antiporter activity
I6J55_RS08165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J55_RS08180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J55_RS08185	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J55_RS08190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J55_RS08195	COG3189	MarR family transcriptional regulator
I6J55_RS08200	COG2885	chlorophyll binding
I6J55_RS08210	COG2217	Heavy metal translocating P-type atpase
I6J55_RS08215	COG2855	membrane
I6J55_RS08225	COG3119	arylsulfatase activity
I6J55_RS08240	COG1063	alcohol dehydrogenase
I6J55_RS08265	COG1193	negative regulation of DNA recombination
I6J55_RS08270	COG0598	Magnesium transport protein CorA
I6J55_RS08275	COG1760	l-serine dehydratase
I6J55_RS08305	COG3634	alkyl hydroperoxide reductase activity
I6J55_RS08315	COG1368	sulfuric ester hydrolase activity
I6J55_RS08320	COG1408	metallophosphoesterase
I6J55_RS08330	COG1629	transport
I6J55_RS08330	COG4206	TonB-dependent receptor
I6J55_RS08355	COG1501	Belongs to the glycosyl hydrolase 31 family
I6J55_RS08370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J55_RS08375	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
I6J55_RS08380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J55_RS08390	COG0514	ATP-dependent DNA helicase (RecQ)
I6J55_RS08415	COG0443	Heat shock 70 kDa protein
I6J55_RS08435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J55_RS08455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J55_RS08470	COG1595	DNA-templated transcription, initiation
I6J55_RS08485	COG2855	membrane
I6J55_RS08490	COG0583	DNA-binding transcription factor activity
I6J55_RS08500	COG0542	response to heat
I6J55_RS08525	COG1862	Preprotein translocase
I6J55_RS08530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J55_RS08540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J55_RS08545	COG0193	aminoacyl-tRNA hydrolase activity
I6J55_RS08550	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J55_RS08570	COG1082	Xylose isomerase domain protein TIM barrel
I6J55_RS08575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J55_RS08585	COG0148	phosphopyruvate hydratase activity
I6J55_RS08600	COG0463	Glycosyl transferase, family 2
I6J55_RS08615	COG1971	Probably functions as a manganese efflux pump
I6J55_RS08620	COG1477	protein flavinylation
I6J55_RS08630	COG0037	tRNA processing
I6J55_RS08645	COG4864	UPF0365 protein
I6J55_RS08655	COG2176	DNA-directed DNA polymerase activity
I6J55_RS08660	COG2910	NAD(P)H-binding
I6J55_RS08665	COG0784	Response regulator, receiver
I6J55_RS08665	COG5002	protein histidine kinase activity
I6J55_RS08670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J55_RS08675	COG1028	Short-chain dehydrogenase reductase Sdr
I6J55_RS08680	COG1501	Belongs to the glycosyl hydrolase 31 family
I6J55_RS08695	COG0564	pseudouridine synthase activity
I6J55_RS08715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J55_RS08735	COG1288	antiporter activity
I6J55_RS08770	COG2706	6-phosphogluconolactonase activity
I6J55_RS08790	COG1496	oxidoreductase activity
I6J55_RS08795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J55_RS08800	COG0563	adenylate kinase activity
I6J55_RS08805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J55_RS08810	COG4771	TonB-dependent receptor
I6J55_RS08825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J55_RS08830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS08875	COG1216	Glycosyl transferase, family 2
I6J55_RS08880	COG5039	Polysaccharide pyruvyl transferase
I6J55_RS08905	COG2226	methyltransferase
I6J55_RS08915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J55_RS08955	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J55_RS08965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J55_RS08975	COG1253	flavin adenine dinucleotide binding
I6J55_RS09005	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
I6J55_RS09025	COG3119	arylsulfatase activity
I6J55_RS09030	COG3119	arylsulfatase activity
I6J55_RS09035	COG0702	epimerase
I6J55_RS09040	COG1629	transport
I6J55_RS09040	COG4206	TonB-dependent receptor
I6J55_RS09055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J55_RS09070	COG4771	TonB-dependent receptor
I6J55_RS09090	COG2205	protein histidine kinase activity
I6J55_RS09090	COG2198	Histidine kinase
I6J55_RS09090	COG0784	Response regulator, receiver
I6J55_RS09095	COG0525	valine-tRNA ligase activity
I6J55_RS09105	COG3956	TIGRFAM MazG family protein
I6J55_RS09120	COG1595	DNA-templated transcription, initiation
I6J55_RS09155	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS09160	COG0492	ferredoxin-NADP+ reductase activity
I6J55_RS09170	COG1674	ftsk spoiiie
I6J55_RS09185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J55_RS09195	COG3547	Transposase (IS116 IS110 IS902 family)
I6J55_RS09205	COG2211	Major facilitator Superfamily
I6J55_RS09225	COG1136	(ABC) transporter
I6J55_RS09235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J55_RS09240	COG1597	lipid kinase activity
I6J55_RS09245	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6J55_RS09250	COG0612	Peptidase, M16
I6J55_RS09265	COG0791	NLP P60 protein
I6J55_RS09270	COG0546	phosphoglycolate phosphatase activity
I6J55_RS09275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J55_RS09280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J55_RS09285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J55_RS09295	COG0543	2 iron, 2 sulfur cluster binding
I6J55_RS09300	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J55_RS09305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J55_RS09310	COG0297	glycogen (starch) synthase activity
I6J55_RS09365	COG2873	o-acetylhomoserine
I6J55_RS09370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J55_RS09375	COG0561	phosphatase activity
I6J55_RS09380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J55_RS09390	COG0009	L-threonylcarbamoyladenylate synthase
I6J55_RS09400	COG0363	glucosamine-6-phosphate deaminase activity
I6J55_RS09410	COG1242	4 iron, 4 sulfur cluster binding
I6J55_RS09455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J55_RS09460	COG4206	TonB-dependent receptor
I6J55_RS09460	COG1629	transport
I6J55_RS09470	COG4206	TonB-dependent receptor
I6J55_RS09470	COG1629	transport
I6J55_RS09480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J55_RS09480	COG0519	Catalyzes the synthesis of GMP from XMP
I6J55_RS09485	COG1970	mechanosensitive ion channel activity
I6J55_RS09495	COG0339	signal peptide processing
I6J55_RS09505	COG2131	deaminase
I6J55_RS09510	COG0793	Belongs to the peptidase S41A family
I6J55_RS09515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J55_RS09555	COG0673	inositol 2-dehydrogenase activity
I6J55_RS09560	COG0702	epimerase
I6J55_RS09565	COG1629	transport
I6J55_RS09565	COG4206	TonB-dependent receptor
I6J55_RS09575	COG4771	TonB-dependent receptor
I6J55_RS09590	COG4206	TonB-dependent receptor
I6J55_RS09590	COG1629	transport
I6J55_RS09600	COG4206	TonB-dependent receptor
I6J55_RS09600	COG1629	transport
I6J55_RS09605	COG0561	phosphatase activity
I6J55_RS09630	COG2814	Major facilitator Superfamily
I6J55_RS09635	COG0457	Tetratricopeptide repeat
I6J55_RS09660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J55_RS09665	COG3250	beta-galactosidase activity
I6J55_RS09685	COG0101	tRNA pseudouridine synthase activity
I6J55_RS09695	COG5434	Belongs to the glycosyl hydrolase 28 family
I6J55_RS09705	COG2268	Band 7 protein
I6J55_RS09715	COG1702	phosphate starvation-inducible protein PhoH
I6J55_RS09720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J55_RS09725	COG2226	methyltransferase
I6J55_RS09730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J55_RS09745	COG1704	LemA family
I6J55_RS09750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J55_RS09755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J55_RS09765	COG1078	dGTPase activity
I6J55_RS09770	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J55_RS09775	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6J55_RS09775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J55_RS09780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J55_RS09820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J55_RS09825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J55_RS09830	COG0805	protein transport
I6J55_RS09855	COG2271	Major facilitator Superfamily
I6J55_RS09860	COG0745	RESPONSE REGULATOR receiver
I6J55_RS09860	COG2205	protein histidine kinase activity
I6J55_RS09860	COG3292	Two component regulator propeller
I6J55_RS09865	COG4771	TonB-dependent receptor
I6J55_RS09875	COG3119	arylsulfatase activity
I6J55_RS09890	COG3119	arylsulfatase activity
I6J55_RS09895	COG0546	phosphoglycolate phosphatase activity
I6J55_RS09905	COG1073	alpha beta
I6J55_RS09910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J55_RS09915	COG0569	domain protein
I6J55_RS09920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J55_RS09930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J55_RS09935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J55_RS09940	COG0649	NAD binding
I6J55_RS09940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J55_RS09945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J55_RS09955	COG0839	Belongs to the complex I subunit 6 family
I6J55_RS09960	COG0713	ATP synthesis coupled electron transport
I6J55_RS09965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J55_RS09970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J55_RS09980	COG2202	Pas domain
I6J55_RS09980	COG2205	protein histidine kinase activity
I6J55_RS10015	COG2942	2-epimerase
I6J55_RS10020	COG2211	Major facilitator Superfamily
I6J55_RS10025	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
I6J55_RS10030	COG4124	Belongs to the glycosyl hydrolase 26 family
I6J55_RS10045	COG5012	cobalamin binding
I6J55_RS10085	COG0702	epimerase
I6J55_RS10090	COG4771	TonB-dependent receptor
I6J55_RS10095	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J55_RS10100	COG0667	Aldo Keto reductase
I6J55_RS10125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J55_RS10130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J55_RS10135	COG1028	Short-chain dehydrogenase reductase Sdr
I6J55_RS10150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J55_RS10210	COG1215	transferase activity, transferring glycosyl groups
I6J55_RS10260	COG2207	Transcriptional regulator
I6J55_RS10260	COG0662	Cupin 2, conserved barrel domain protein
I6J55_RS10265	COG0668	transmembrane transport
I6J55_RS10335	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J55_RS10345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J55_RS10350	COG2239	Acts as a magnesium transporter
I6J55_RS10365	COG0799	negative regulation of ribosome biogenesis
I6J55_RS10370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J55_RS10375	COG4589	Belongs to the CDS family
I6J55_RS10385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J55_RS10390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6J55_RS10395	COG1192	Involved in chromosome partitioning
I6J55_RS10400	COG1475	DNA binding
I6J55_RS10410	COG3942	CHAP domain
I6J55_RS10410	COG1388	LysM domain
I6J55_RS10415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J55_RS10425	COG0739	heme binding
I6J55_RS10440	COG2814	Major facilitator Superfamily
I6J55_RS10445	COG3537	Alpha-1,2-mannosidase
I6J55_RS10460	COG3537	Alpha-1,2-mannosidase
I6J55_RS10465	COG3537	Alpha-1,2-mannosidase
I6J55_RS10470	COG4771	TonB-dependent receptor
I6J55_RS10495	COG0742	ribosomal rna small subunit methyltransferase
I6J55_RS10500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J55_RS10515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J55_RS10540	COG0784	Response regulator, receiver
I6J55_RS10540	COG2205	protein histidine kinase activity
I6J55_RS10550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J55_RS10555	COG3250	beta-galactosidase activity
I6J55_RS10575	COG1629	transport
I6J55_RS10595	COG2234	aminopeptidase activity
I6J55_RS10605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J55_RS10610	COG0802	atpase or kinase
I6J55_RS10625	COG0714	Associated with various cellular activities
I6J55_RS10660	COG3118	belongs to the thioredoxin family
I6J55_RS10670	COG0688	phosphatidylethanolamine metabolic process
I6J55_RS10675	COG1183	phosphatidylcholine synthase activity
I6J55_RS10695	COG0792	nuclease activity
I6J55_RS10725	COG0534	Mate efflux family protein
I6J55_RS10730	COG0528	UMP kinase activity
I6J55_RS10740	COG0233	cytoplasmic translational termination
I6J55_RS10745	COG1162	GTPase activity
I6J55_RS10755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J55_RS10760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J55_RS10770	COG0531	amino acid
I6J55_RS10785	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J55_RS10785	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J55_RS10800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J55_RS10805	COG0702	epimerase
I6J55_RS10810	COG4771	TonB-dependent receptor
I6J55_RS10820	COG1629	transport
I6J55_RS10820	COG4206	TonB-dependent receptor
I6J55_RS10825	COG4974	Belongs to the 'phage' integrase family
I6J55_RS10830	COG4771	TonB-dependent receptor
I6J55_RS10840	COG1629	transport
I6J55_RS10850	COG2095	MarC family integral membrane protein
I6J55_RS10865	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J55_RS10880	COG0628	permease
I6J55_RS10900	COG4771	TonB-dependent receptor
I6J55_RS10915	COG3507	Belongs to the glycosyl hydrolase 43 family
I6J55_RS10925	COG3250	beta-galactosidase activity
I6J55_RS10930	COG0702	epimerase
I6J55_RS10935	COG4206	TonB-dependent receptor
I6J55_RS10935	COG1629	transport
I6J55_RS10985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J55_RS10990	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
I6J55_RS10995	COG0527	aspartate kinase activity
I6J55_RS10995	COG0460	homoserine dehydrogenase
I6J55_RS11000	COG0252	asparaginase activity
I6J55_RS11005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J55_RS11015	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6J55_RS11020	COG2197	response regulator
I6J55_RS11025	COG4771	TonB-dependent receptor
I6J55_RS11035	COG0826	peptidase U32
I6J55_RS11050	COG3250	beta-galactosidase activity
I6J55_RS11055	COG0436	Aminotransferase
I6J55_RS11060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J55_RS11060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J55_RS11105	COG4771	TonB-dependent receptor
I6J55_RS11120	COG5002	protein histidine kinase activity
I6J55_RS11125	COG2205	protein histidine kinase activity
I6J55_RS11145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J55_RS11155	COG2204	response regulator
I6J55_RS11170	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J55_RS11195	COG3119	arylsulfatase activity
I6J55_RS11205	COG1629	transport
I6J55_RS11205	COG4206	TonB-dependent receptor
I6J55_RS11210	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J55_RS11215	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J55_RS11220	COG0737	Belongs to the 5'-nucleotidase family
I6J55_RS11225	COG0737	Belongs to the 5'-nucleotidase family
I6J55_RS11230	COG0335	large ribosomal subunit rRNA binding
I6J55_RS11235	COG1940	carbohydrate kinase activity
I6J55_RS11240	COG1136	(ABC) transporter
I6J55_RS11245	COG0577	efflux transmembrane transporter activity
I6J55_RS11245	COG1136	(ABC) transporter
I6J55_RS11250	COG0577	efflux transmembrane transporter activity
I6J55_RS11250	COG1136	(ABC) transporter
I6J55_RS11275	COG1629	transport
I6J55_RS11300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J55_RS11305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J55_RS11325	COG2996	Protein conserved in bacteria
I6J55_RS11330	COG0039	L-malate dehydrogenase activity
I6J55_RS11340	COG0531	amino acid
I6J55_RS11345	COG0784	Response regulator, receiver
I6J55_RS11345	COG2205	protein histidine kinase activity
I6J55_RS11370	COG0137	argininosuccinate synthase activity
I6J55_RS11380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J55_RS11385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J55_RS11390	COG1917	Cupin 2, conserved barrel domain protein
I6J55_RS11390	COG1396	sequence-specific DNA binding
I6J55_RS11395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J55_RS11430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J55_RS11435	COG2137	regulation of response to DNA damage stimulus
I6J55_RS11440	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J55_RS11445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J55_RS11445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J55_RS11455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J55_RS11475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J55_RS11485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J55_RS11490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J55_RS11530	COG0564	pseudouridine synthase activity
I6J55_RS11535	COG0515	serine threonine protein kinase
I6J55_RS11535	COG2815	serine threonine protein kinase
I6J55_RS11540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J55_RS11550	COG0463	Glycosyl transferase, family 2
I6J55_RS11550	COG1216	Glycosyl transferase, family 2
I6J55_RS11555	COG2003	Belongs to the UPF0758 family
I6J55_RS11560	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J55_RS11565	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J55_RS11570	COG1785	Belongs to the alkaline phosphatase family
I6J55_RS11575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J55_RS11580	COG0280	phosphate acetyltransferase
I6J55_RS11605	COG1346	cytolysis
I6J55_RS11710	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J55_RS11715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J55_RS11720	COG0784	Response regulator, receiver
I6J55_RS11720	COG2198	Histidine kinase
I6J55_RS11720	COG5002	protein histidine kinase activity
I6J55_RS11725	COG2066	Belongs to the glutaminase family
I6J55_RS11730	COG0076	glutamate decarboxylase activity
I6J55_RS11740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J55_RS11750	COG0733	neurotransmitter:sodium symporter activity
I6J55_RS11760	COG1136	(ABC) transporter
I6J55_RS11765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J55_RS11770	COG0475	glutathione-regulated potassium exporter activity
I6J55_RS11770	COG0589	response to stress
I6J55_RS11775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J55_RS11785	COG4206	TonB-dependent receptor
I6J55_RS11785	COG1629	transport
I6J55_RS11790	COG0702	epimerase
I6J55_RS11795	COG3876	Protein conserved in bacteria
I6J55_RS11800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J55_RS11835	COG3876	Protein conserved in bacteria
I6J55_RS11875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J55_RS11885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6J55_RS11890	COG3005	denitrification pathway
I6J55_RS11905	COG0423	glycine-tRNA ligase activity
I6J55_RS11930	COG4771	TonB-dependent receptor
I6J55_RS11965	COG4771	TonB-dependent receptor
I6J55_RS11990	COG2205	protein histidine kinase activity
I6J55_RS11990	COG3292	Two component regulator propeller
I6J55_RS11990	COG0745	RESPONSE REGULATOR receiver
I6J55_RS11995	COG2205	protein histidine kinase activity
I6J55_RS11995	COG0745	RESPONSE REGULATOR receiver
I6J55_RS11995	COG3292	Two component regulator propeller
I6J55_RS12000	COG4206	TonB-dependent receptor
I6J55_RS12000	COG1629	transport
I6J55_RS12015	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J55_RS12025	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS12030	COG3250	beta-galactosidase activity
I6J55_RS12050	COG2954	triphosphatase activity
I6J55_RS12065	COG1022	Amp-dependent synthetase and ligase
I6J55_RS12070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J55_RS12075	COG3408	Glycogen debranching enzyme
I6J55_RS12145	COG2017	converts alpha-aldose to the beta-anomer
I6J55_RS12155	COG3537	Alpha-1,2-mannosidase
I6J55_RS12175	COG3507	Belongs to the glycosyl hydrolase 43 family
I6J55_RS12195	COG1629	transport
I6J55_RS12195	COG4206	TonB-dependent receptor
I6J55_RS12200	COG0383	alpha-mannosidase activity
I6J55_RS12200	COG0383	alpha-mannosidase activity
I6J55_RS12220	COG3940	Belongs to the glycosyl hydrolase 43 family
I6J55_RS12235	COG3250	beta-galactosidase activity
I6J55_RS12250	COG3940	Belongs to the glycosyl hydrolase 43 family
I6J55_RS12255	COG0745	RESPONSE REGULATOR receiver
I6J55_RS12255	COG2205	protein histidine kinase activity
I6J55_RS12255	COG3292	Two component regulator propeller
I6J55_RS12260	COG4942	peptidase
I6J55_RS12275	COG0756	dUTP diphosphatase activity
I6J55_RS12300	COG4771	TonB-dependent receptor
I6J55_RS12320	COG2001	Belongs to the MraZ family
I6J55_RS12325	COG0275	rRNA processing
I6J55_RS12340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J55_RS12345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J55_RS12350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J55_RS12355	COG0772	Belongs to the SEDS family
I6J55_RS12360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J55_RS12365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J55_RS12380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J55_RS12385	COG1610	YqeY-like protein
I6J55_RS12390	COG1381	Involved in DNA repair and RecF pathway recombination
I6J55_RS12400	COG0268	Binds directly to 16S ribosomal RNA
I6J55_RS12405	COG0187	DNA topoisomerase II activity
I6J55_RS12425	COG2205	protein histidine kinase activity
I6J55_RS12425	COG2202	Pas domain
I6J55_RS12440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J55_RS12445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J55_RS12470	COG1629	transport
I6J55_RS12480	COG3345	alpha-galactosidase
I6J55_RS12485	COG0393	Putative heavy-metal-binding
I6J55_RS12490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J55_RS12495	COG0719	Fe-S assembly protein
I6J55_RS12500	COG0396	ATPase activity
I6J55_RS12510	COG0719	Fe-S assembly protein
I6J55_RS12520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J55_RS12525	COG0195	Participates in both transcription termination and antitermination
I6J55_RS12530	COG0779	Required for maturation of 30S ribosomal subunits
I6J55_RS12535	COG0738	Major facilitator superfamily
I6J55_RS12540	COG1070	Carbohydrate kinase
I6J55_RS12545	COG0235	Class ii aldolase
I6J55_RS12550	COG1454	alcohol dehydrogenase
I6J55_RS12625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J55_RS12630	COG1166	arginine decarboxylase activity
I6J55_RS12640	COG0326	Molecular chaperone. Has ATPase activity
I6J55_RS12650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J55_RS12660	COG0328	RNA-DNA hybrid ribonuclease activity
I6J55_RS12660	COG3341	Caulimovirus viroplasmin
I6J55_RS12670	COG1132	(ABC) transporter
I6J55_RS12675	COG1216	Glycosyl transferase, family 2
I6J55_RS12675	COG1442	glycosyl transferase family 8
I6J55_RS12680	COG1215	transferase activity, transferring glycosyl groups
I6J55_RS12690	COG1442	glycosyl transferase family 8
I6J55_RS12705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J55_RS12710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J55_RS12715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J55_RS12720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J55_RS12730	COG0205	6-phosphofructokinase activity
I6J55_RS12745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J55_RS12760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J55_RS12765	COG5002	protein histidine kinase activity
I6J55_RS12770	COG0745	RESPONSE REGULATOR receiver
I6J55_RS12790	COG0745	RESPONSE REGULATOR receiver
I6J55_RS12795	COG0561	phosphatase activity
I6J55_RS12800	COG0215	cysteine-tRNA ligase activity
I6J55_RS12820	COG3250	beta-galactosidase activity
I6J55_RS12825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J55_RS12840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J55_RS12870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J55_RS12875	COG0681	Belongs to the peptidase S26 family
I6J55_RS12880	COG0681	Belongs to the peptidase S26 family
I6J55_RS12890	COG1028	Short-chain dehydrogenase reductase Sdr
I6J55_RS12895	COG1312	Catalyzes the dehydration of D-mannonate
I6J55_RS12910	COG0612	Peptidase, M16
I6J55_RS12925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J55_RS12935	COG0513	Belongs to the DEAD box helicase family
I6J55_RS12945	COG3591	Belongs to the peptidase S1B family
I6J55_RS12960	COG2255	four-way junction helicase activity
I6J55_RS12970	COG2715	membrane protein required for spore maturation
I6J55_RS12990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J55_RS13025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J55_RS13030	COG0322	excinuclease ABC activity
I6J55_RS13040	COG1694	Mazg nucleotide pyrophosphohydrolase
I6J55_RS13045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J55_RS13060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J55_RS13060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J55_RS13070	COG3279	Response regulator of the LytR AlgR family
I6J55_RS13075	COG3275	phosphorelay sensor kinase activity
I6J55_RS13080	COG1045	serine acetyltransferase
I6J55_RS13085	COG0116	Belongs to the methyltransferase superfamily
I6J55_RS13090	COG0823	Involved in the tonB-independent uptake of proteins
I6J55_RS13090	COG1506	peptidase
I6J55_RS13095	COG0151	Belongs to the GarS family
I6J55_RS13110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J55_RS13110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6J55_RS13120	COG1121	(ABC) transporter
I6J55_RS13145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J55_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
I6J55_RS13160	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6J55_RS13165	COG3119	arylsulfatase activity
I6J55_RS13175	COG1506	peptidase
I6J55_RS13175	COG0823	Involved in the tonB-independent uptake of proteins
I6J55_RS13175	COG4946	Tricorn protease homolog
I6J55_RS13190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J55_RS13195	COG0594	ribonuclease P activity
I6J55_RS13210	COG1611	Belongs to the LOG family
I6J55_RS13215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J55_RS13225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J55_RS13230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J55_RS13235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J55_RS13240	COG1968	undecaprenyl-diphosphatase activity
I6J55_RS13250	COG2177	Part of the ABC transporter FtsEX involved in
I6J55_RS13335	COG3250	beta-galactosidase activity
I6J55_RS13345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J55_RS13355	COG0427	acetyl-CoA hydrolase
I6J55_RS13375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J55_RS13380	COG1592	Rubrerythrin
I6J55_RS13385	COG0659	secondary active sulfate transmembrane transporter activity
I6J55_RS13410	COG0731	radical SAM domain protein
I6J55_RS13410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J55_RS13470	COG1215	transferase activity, transferring glycosyl groups
I6J55_RS13490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J55_RS13500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J55_RS13515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J55_RS13525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J55_RS13530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J55_RS13535	COG0012	GTP binding
I6J55_RS13570	COG0557	exoribonuclease II activity
I6J55_RS13575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6J55_RS13590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J55_RS13600	COG0826	peptidase U32
I6J55_RS13610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J55_RS13610	COG0758	DNA mediated transformation
I6J55_RS13635	COG4771	TonB-dependent receptor
I6J55_RS13650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J55_RS13655	COG1053	succinate dehydrogenase
I6J55_RS13675	COG0793	Belongs to the peptidase S41A family
I6J55_RS13675	COG3409	Peptidoglycan-binding domain 1 protein
I6J55_RS13680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J55_RS13715	COG1621	beta-fructofuranosidase activity
I6J55_RS13720	COG3292	Two component regulator propeller
I6J55_RS13720	COG2205	protein histidine kinase activity
I6J55_RS13720	COG0745	RESPONSE REGULATOR receiver
I6J55_RS13740	COG2814	Major facilitator Superfamily
I6J55_RS13750	COG1629	transport
I6J55_RS13750	COG4206	TonB-dependent receptor
I6J55_RS13815	COG3275	phosphorelay sensor kinase activity
I6J55_RS13835	COG1522	sequence-specific DNA binding
I6J55_RS13840	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J55_RS13845	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J55_RS13850	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J55_RS13860	COG0438	transferase activity, transferring glycosyl groups
I6J55_RS13865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J55_RS13890	COG0438	transferase activity, transferring glycosyl groups
I6J55_RS13940	COG0745	RESPONSE REGULATOR receiver
I6J55_RS13940	COG2205	protein histidine kinase activity
I6J55_RS13940	COG3292	Two component regulator propeller
I6J55_RS13980	COG0582	viral genome integration into host DNA
I6J55_RS14015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J55_RS14025	COG4974	Belongs to the 'phage' integrase family
I6J55_RS14030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J55_RS14045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J55_RS14050	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J55_RS14065	COG1629	transport
I6J55_RS14065	COG4206	TonB-dependent receptor
I6J55_RS14075	COG3119	arylsulfatase activity
I6J55_RS14090	COG2205	protein histidine kinase activity
I6J55_RS14090	COG4999	Histidine kinase
I6J55_RS14090	COG3850	Histidine kinase
I6J55_RS14090	COG3437	response regulator, receiver
I6J55_RS14095	COG0318	PFAM AMP-dependent synthetase and ligase
I6J55_RS14105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J55_RS14110	COG1217	gtp-binding protein TYPA
I6J55_RS14120	COG1629	transport
I6J55_RS14160	COG1629	transport
I6J55_RS14165	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6J55_RS14170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J55_RS14175	COG0584	glycerophosphoryl diester phosphodiesterase
I6J55_RS14185	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J55_RS14190	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J55_RS14190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J55_RS14205	COG1609	Transcriptional regulator
I6J55_RS14205	COG2207	Transcriptional regulator
I6J55_RS14240	COG0776	regulation of translation
I6J55_RS14245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J55_RS14350	COG1442	glycosyl transferase family 8
I6J55_RS14380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J55_RS14385	COG3475	LICD family
I6J55_RS14410	COG3345	alpha-galactosidase
I6J55_RS14420	COG0483	inositol monophosphate 1-phosphatase activity
I6J55_RS14425	COG1040	competence protein
I6J55_RS14445	COG2814	Major facilitator Superfamily
I6J55_RS14445	COG0477	Major facilitator Superfamily
I6J55_RS14450	COG1882	Formate acetyltransferase
I6J55_RS14455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J55_RS14465	COG4771	TonB-dependent receptor
I6J55_RS14500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J55_RS14505	COG0793	Belongs to the peptidase S41A family
I6J55_RS14520	COG4771	TonB-dependent receptor
I6J55_RS14525	COG0702	epimerase
I6J55_RS14550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J55_RS14555	COG0509	glycine decarboxylation via glycine cleavage system
I6J55_RS14570	COG0006	proline dipeptidase activity
I6J55_RS14595	COG2205	protein histidine kinase activity
I6J55_RS14605	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J55_RS14610	COG1773	rubredoxin
I6J55_RS14615	COG2205	protein histidine kinase activity
I6J55_RS14615	COG0784	Response regulator, receiver
I6J55_RS14620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J55_RS14625	COG1011	Hydrolase
I6J55_RS14630	COG0196	riboflavin kinase activity
I6J55_RS14635	COG1266	CAAX protease self-immunity
I6J55_RS14645	COG3655	Transcriptional regulator
I6J55_RS14650	COG2166	iron-sulfur cluster assembly
I6J55_RS14655	COG2234	aminopeptidase activity
I6J55_RS14660	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J55_RS14670	COG0280	phosphate acetyltransferase
I6J55_RS14675	COG3426	butyrate kinase activity
I6J55_RS14700	COG4771	TonB-dependent receptor
I6J55_RS14715	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J55_RS14725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J55_RS14805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J55_RS14835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J55_RS14840	COG2207	Transcriptional regulator
I6J55_RS14840	COG0662	Cupin 2, conserved barrel domain protein
I6J55_RS14855	COG2197	response regulator
I6J55_RS14875	COG4771	TonB-dependent receptor
I6J55_RS14890	COG3279	Response regulator of the LytR AlgR family
I6J55_RS14895	COG3275	phosphorelay sensor kinase activity
I6J55_RS14940	COG2755	lipolytic protein G-D-S-L family
I6J55_RS14940	COG0657	acetylesterase activity
I6J55_RS14985	COG2096	Adenosyltransferase
I6J55_RS15000	COG0252	asparaginase activity
I6J55_RS15005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J55_RS15010	COG1027	Aspartate ammonia-lyase
I6J55_RS15030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J55_RS15040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J55_RS15045	COG1480	7TM receptor with intracellular HD hydrolase
I6J55_RS15050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J55_RS15060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J55_RS15070	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6J55_RS15075	COG4974	Belongs to the 'phage' integrase family
I6J55_RS15080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J55_RS15125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J55_RS15130	COG0081	regulation of translation
I6J55_RS15135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J55_RS15140	COG0222	ribosome binding
I6J55_RS15145	COG0085	RNA polymerase activity
I6J55_RS15150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J55_RS15180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J55_RS15185	COG0049	tRNA binding
I6J55_RS15190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J55_RS15195	COG0051	transcription antitermination factor activity, RNA binding
I6J55_RS15200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J55_RS15205	COG0088	Forms part of the polypeptide exit tunnel
I6J55_RS15210	COG0089	rRNA binding
I6J55_RS15215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J55_RS15220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J55_RS15225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J55_RS15230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J55_RS15235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J55_RS15240	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J55_RS15245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J55_RS15250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J55_RS15255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J55_RS15260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J55_RS15265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J55_RS15270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J55_RS15275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J55_RS15280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J55_RS15285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J55_RS15290	COG1841	ribosomal large subunit assembly
I6J55_RS15295	COG0200	Binds to the 23S rRNA
I6J55_RS15310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J55_RS15315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J55_RS15320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J55_RS15325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J55_RS15330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J55_RS15335	COG0202	RNA polymerase activity
I6J55_RS15340	COG0203	ribosomal protein L17
I6J55_RS15365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J55_RS15375	COG1228	amidohydrolase
I6J55_RS15385	COG2986	histidine ammonia-lyase
I6J55_RS15425	COG1696	Membrane protein involved in D-alanine export
I6J55_RS15435	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
I6J55_RS15455	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6J55_RS15530	COG1131	(ABC) transporter
I6J55_RS15550	COG2312	Erythromycin esterase
I6J55_RS15585	COG0564	pseudouridine synthase activity
I6J55_RS15605	COG0612	Peptidase, M16
I6J55_RS15610	COG0534	Mate efflux family protein
I6J55_RS15615	COG0784	Response regulator, receiver
I6J55_RS15615	COG2205	protein histidine kinase activity
I6J55_RS15640	COG0488	(ABC) transporter
I6J55_RS15645	COG3590	peptidase
I6J55_RS15650	COG0138	bifunctional purine biosynthesis protein purh
I6J55_RS15660	COG1792	Involved in formation and maintenance of cell shape
I6J55_RS15675	COG0772	Belongs to the SEDS family
I6J55_RS15685	COG1774	PSP1 C-terminal conserved region
I6J55_RS15690	COG0470	DNA polymerase III
I6J55_RS15695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J55_RS15740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J55_RS15745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J55_RS15750	COG1160	GTP binding
I6J55_RS15755	COG2197	response regulator
I6J55_RS15760	COG1127	ABC transporter
I6J55_RS15765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J55_RS15775	COG0724	RNA recognition motif
I6J55_RS15790	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J55_RS15795	COG0514	ATP-dependent DNA helicase (RecQ)
I6J55_RS15800	COG0517	IMP dehydrogenase activity
I6J55_RS15800	COG0516	GMP reductase activity
I6J55_RS15815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J55_RS15830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J55_RS15840	COG4680	protein conserved in bacteria
I6J55_RS15930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J55_RS15955	COG1442	glycosyl transferase family 8
I6J55_RS15955	COG1216	Glycosyl transferase, family 2
I6J55_RS15990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J55_RS16045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS16050	COG3022	response to hydroperoxide
I6J55_RS16055	COG0110	maltose O-acetyltransferase activity
I6J55_RS16085	COG1187	pseudouridine synthase activity
I6J55_RS16090	COG0017	Asparaginyl-tRNA synthetase
I6J55_RS16105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J55_RS16110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J55_RS16115	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J55_RS16120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J55_RS16130	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J55_RS16135	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J55_RS16160	COG0482	sulfurtransferase activity
I6J55_RS16170	COG1570	exodeoxyribonuclease VII activity
I6J55_RS16175	COG1722	exodeoxyribonuclease VII activity
I6J55_RS16180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J55_RS16195	COG0489	protein tyrosine kinase activity
I6J55_RS16200	COG3118	belongs to the thioredoxin family
I6J55_RS16205	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6J55_RS16225	COG4948	Mandelate Racemase Muconate Lactonizing
I6J55_RS16240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J55_RS16270	COG0039	L-malate dehydrogenase activity
I6J55_RS16305	COG1629	transport
I6J55_RS16350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J55_RS16360	COG0811	peptide transport
I6J55_RS16385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J55_RS16390	COG0105	UTP biosynthetic process
I6J55_RS16395	COG0739	heme binding
I6J55_RS16410	COG0149	triose-phosphate isomerase activity
I6J55_RS16420	COG0302	gtp cyclohydrolase
I6J55_RS16435	COG1629	transport
I6J55_RS16435	COG4206	TonB-dependent receptor
I6J55_RS16450	COG3119	arylsulfatase activity
I6J55_RS16455	COG0358	DNA primase activity
I6J55_RS16465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J55_RS16470	COG0436	Aminotransferase
I6J55_RS16480	COG2186	Transcriptional regulator
I6J55_RS16485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J55_RS16490	COG4771	TonB-dependent receptor
I6J55_RS16495	COG0702	epimerase
I6J55_RS16510	COG2271	Major facilitator Superfamily
I6J55_RS16520	COG0514	ATP-dependent DNA helicase (RecQ)
I6J55_RS16525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J55_RS16525	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J55_RS16530	COG2818	Glycosylase
I6J55_RS16555	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J55_RS16565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J55_RS16575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J55_RS16580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J55_RS16590	COG2244	polysaccharide biosynthetic process
I6J55_RS16610	COG0673	inositol 2-dehydrogenase activity
I6J55_RS16625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J55_RS16635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J55_RS16665	COG0009	L-threonylcarbamoyladenylate synthase
I6J55_RS16675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J55_RS16680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J55_RS16685	COG0658	competence protein
I6J55_RS16690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J55_RS16700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J55_RS16715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J55_RS16735	COG3279	Response regulator of the LytR AlgR family
I6J55_RS16740	COG3275	phosphorelay sensor kinase activity
I6J55_RS16760	COG0386	Belongs to the glutathione peroxidase family
I6J55_RS16765	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J55_RS16770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J55_RS16800	COG2431	L-lysine efflux transmembrane transporter activity
I6J55_RS16815	COG4771	TonB-dependent receptor
I6J55_RS16835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J55_RS16840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J55_RS16865	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J55_RS16870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J55_RS16885	COG1022	Amp-dependent synthetase and ligase
I6J55_RS16890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J55_RS16910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J55_RS16915	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J55_RS16925	COG1640	4-alpha-glucanotransferase
I6J55_RS16940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J55_RS16950	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J55_RS16965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS16980	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J55_RS16985	COG2502	aspartate--ammonia ligase
I6J55_RS16995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J55_RS17005	COG0166	Belongs to the GPI family
I6J55_RS17010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J55_RS17015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J55_RS17020	COG0534	Mate efflux family protein
I6J55_RS17055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J55_RS17060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J55_RS17060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J55_RS17095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J55_RS17110	COG4771	TonB-dependent receptor
I6J55_RS17120	COG3291	Pkd domain containing protein
I6J55_RS17120	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS17125	COG4206	TonB-dependent receptor
I6J55_RS17125	COG1629	transport
I6J55_RS17130	COG0702	epimerase
I6J55_RS17145	COG4771	TonB-dependent receptor
I6J55_RS17150	COG0702	epimerase
I6J55_RS17160	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6J55_RS17195	COG3681	Belongs to the UPF0597 family
I6J55_RS17215	COG2885	chlorophyll binding
I6J55_RS17240	COG0129	dihydroxy-acid dehydratase activity
I6J55_RS17265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J55_RS17275	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J55_RS17285	COG0538	isocitrate dehydrogenase activity
I6J55_RS17290	COG0372	Belongs to the citrate synthase family
I6J55_RS17310	COG0205	6-phosphofructokinase activity
I6J55_RS17315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J55_RS17320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J55_RS17325	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6J55_RS17340	COG0084	hydrolase, TatD family'
I6J55_RS17350	COG0811	peptide transport
I6J55_RS17375	COG1522	sequence-specific DNA binding
I6J55_RS17385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J55_RS17460	COG0488	(ABC) transporter
I6J55_RS17465	COG2204	response regulator
I6J55_RS17475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J55_RS17485	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J55_RS17490	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J55_RS17495	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J55_RS17500	COG1408	metallophosphoesterase
I6J55_RS17505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J55_RS17510	COG0194	GDP metabolic process
I6J55_RS17525	COG2205	protein histidine kinase activity
I6J55_RS17525	COG2198	Histidine kinase
I6J55_RS17525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J55_RS17525	COG0784	Response regulator, receiver
I6J55_RS17530	COG1214	PFAM Peptidase M22, glycoprotease
I6J55_RS17540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J55_RS17545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J55_RS17560	COG0750	zinc metalloprotease
I6J55_RS17570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J55_RS17580	COG2814	Major facilitator Superfamily
I6J55_RS17590	COG1328	CTP reductase activity
I6J55_RS17595	COG1272	protein, Hemolysin III
I6J55_RS17600	COG0673	inositol 2-dehydrogenase activity
I6J55_RS17605	COG0632	four-way junction helicase activity
I6J55_RS17640	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6J55_RS17650	COG0776	regulation of translation
I6J55_RS17695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J55_RS17705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J55_RS17720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS17735	COG1215	transferase activity, transferring glycosyl groups
I6J55_RS17760	COG1216	Glycosyl transferase, family 2
I6J55_RS17765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS17785	COG1278	Cold shock
I6J55_RS17795	COG0612	Peptidase, M16
I6J55_RS17820	COG0517	IMP dehydrogenase activity
I6J55_RS17820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J55_RS17820	COG0617	tRNA 3'-terminal CCA addition
I6J55_RS17925	COG4771	TonB-dependent receptor
I6J55_RS17940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J55_RS17965	COG1418	mRNA catabolic process
I6J55_RS17970	COG3142	Participates in the control of copper homeostasis
I6J55_RS17985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J55_RS17990	COG2832	Protein of unknown function (DUF454)
I6J55_RS18000	COG0602	queuosine metabolic process
I6J55_RS18005	COG0247	lactate metabolic process
I6J55_RS18010	COG1139	Iron-sulfur cluster binding protein
I6J55_RS18020	COG0351	phosphomethylpyrimidine kinase
I6J55_RS18030	COG2304	oxidoreductase activity
I6J55_RS18040	COG1629	transport
I6J55_RS18050	COG1393	Belongs to the ArsC family
I6J55_RS18065	COG2233	PERMEase
I6J55_RS18070	COG1509	lysine 2,3-aminomutase activity
I6J55_RS18120	COG0551	DNA topoisomerase type I activity
I6J55_RS18120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J55_RS18135	COG3344	reverse transcriptase
I6J55_RS18150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J55_RS18150	COG0784	Response regulator, receiver
I6J55_RS18150	COG2205	protein histidine kinase activity
I6J55_RS18150	COG2198	Histidine kinase
I6J55_RS18270	COG0358	DNA primase activity
I6J55_RS18340	COG1115	amino acid carrier protein
I6J55_RS18355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J55_RS18355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J55_RS18375	COG1285	pathogenesis
I6J55_RS18385	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J55_RS18385	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J55_RS18390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J55_RS18395	COG1388	LysM domain
I6J55_RS18395	COG0741	lytic transglycosylase activity
I6J55_RS18405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J55_RS18415	COG2217	Heavy metal translocating P-type atpase
I6J55_RS18480	COG2873	o-acetylhomoserine
I6J55_RS18495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J55_RS18500	COG2207	Transcriptional regulator
I6J55_RS18515	COG0516	GMP reductase activity
I6J55_RS18515	COG0517	IMP dehydrogenase activity
I6J55_RS18525	COG1335	isochorismatase
I6J55_RS18530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J55_RS18535	COG0511	ligase activity, forming carbon-carbon bonds
I6J55_RS18535	COG5016	pyruvate
I6J55_RS18540	COG0439	Biotin carboxylase
I6J55_RS18545	COG4651	solute:proton antiporter activity
I6J55_RS18545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J55_RS18555	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J55_RS18615	COG1028	Short-chain dehydrogenase reductase Sdr
I6J55_RS18625	COG3011	Protein conserved in bacteria
I6J55_RS18635	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6J55_RS18650	COG2207	Transcriptional regulator
I6J55_RS18650	COG1917	Cupin 2, conserved barrel domain protein
I6J55_RS18680	COG4206	TonB-dependent receptor
I6J55_RS18680	COG1629	transport
I6J55_RS18685	COG0702	epimerase
I6J55_RS18705	COG4948	Mandelate Racemase Muconate Lactonizing
I6J55_RS18710	COG0745	RESPONSE REGULATOR receiver
I6J55_RS18710	COG3292	Two component regulator propeller
I6J55_RS18710	COG2205	protein histidine kinase activity
I6J55_RS18715	COG2207	Transcriptional regulator
I6J55_RS18730	COG0546	phosphoglycolate phosphatase activity
I6J55_RS18740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J55_RS18745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J55_RS18755	COG0616	signal peptide processing
I6J55_RS18805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J55_RS18810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J55_RS18815	COG0066	3-isopropylmalate dehydratase activity
I6J55_RS18830	COG0463	Glycosyl transferase, family 2
I6J55_RS18850	COG4771	TonB-dependent receptor
I6J55_RS18855	COG0702	epimerase
I6J55_RS18870	COG0671	phosphoesterase, PA-phosphatase related
I6J55_RS18880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J55_RS18920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J55_RS18950	COG1506	peptidase
I6J55_RS18950	COG0823	Involved in the tonB-independent uptake of proteins
I6J55_RS18955	COG3537	Alpha-1,2-mannosidase
I6J55_RS18985	COG2326	polyphosphate kinase activity
I6J55_RS19025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J55_RS19030	COG0459	protein refolding
I6J55_RS19050	COG0028	Belongs to the TPP enzyme family
I6J55_RS19080	COG0492	ferredoxin-NADP+ reductase activity
I6J55_RS19080	COG3118	belongs to the thioredoxin family
I6J55_RS19090	COG2194	sulfuric ester hydrolase activity
I6J55_RS19095	COG0784	Response regulator, receiver
I6J55_RS19095	COG2205	protein histidine kinase activity
I6J55_RS19100	COG0484	heat shock protein binding
I6J55_RS19120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J55_RS19135	COG0702	epimerase
I6J55_RS19140	COG4771	TonB-dependent receptor
I6J55_RS19165	COG4977	sequence-specific DNA binding
I6J55_RS19165	COG1917	Cupin 2, conserved barrel domain protein
I6J55_RS19185	COG3015	lipoprotein NlpE involved in copper resistance
I6J55_RS19210	COG0475	glutathione-regulated potassium exporter activity
I6J55_RS19215	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J55_RS19230	COG0738	Major facilitator superfamily
I6J55_RS19255	COG1621	beta-fructofuranosidase activity
I6J55_RS19265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J55_RS19265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J55_RS19270	COG2205	protein histidine kinase activity
I6J55_RS19270	COG0745	RESPONSE REGULATOR receiver
I6J55_RS19270	COG3292	Two component regulator propeller
I6J55_RS19285	COG4176	ABC-type proline glycine betaine transport system permease component
I6J55_RS19290	COG2113	Glycine betaine
I6J55_RS19320	COG2205	protein histidine kinase activity
I6J55_RS19320	COG0784	Response regulator, receiver
I6J55_RS19325	COG1649	PFAM Uncharacterised BCR, COG1649
I6J55_RS19330	COG1966	Carbon starvation protein
I6J55_RS19350	COG1649	PFAM Uncharacterised BCR, COG1649
I6J55_RS19365	COG2205	protein histidine kinase activity
I6J55_RS19365	COG0745	RESPONSE REGULATOR receiver
I6J55_RS19365	COG3292	Two component regulator propeller
I6J55_RS19370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J55_RS19370	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J55_RS19390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J55_RS19395	COG1554	hydrolase, family 65, central catalytic
I6J55_RS19405	COG1609	Transcriptional regulator
I6J55_RS19410	COG4206	TonB-dependent receptor
I6J55_RS19410	COG1629	transport
I6J55_RS19415	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J55_RS19440	COG0254	rRNA binding
I6J55_RS19450	COG0191	fructose-bisphosphate aldolase activity
I6J55_RS19470	COG0366	Alpha amylase catalytic
I6J55_RS19485	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6J55_RS19490	COG5016	pyruvate
I6J55_RS19490	COG0511	ligase activity, forming carbon-carbon bonds
I6J55_RS19500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J55_RS19515	COG0288	reversible hydration of carbon dioxide
I6J55_RS19520	COG0778	Nitroreductase
I6J55_RS19535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J55_RS19540	COG0424	maF-like protein
I6J55_RS19590	COG2311	Membrane
I6J55_RS19605	COG0126	phosphoglycerate kinase activity
I6J55_RS19610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J55_RS19620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J55_RS19640	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6J55_RS19645	COG1523	belongs to the glycosyl hydrolase 13 family
I6J55_RS19650	COG1595	DNA-templated transcription, initiation
I6J55_RS19660	COG1629	transport
I6J55_RS19660	COG4206	TonB-dependent receptor
I6J55_RS19670	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS19675	COG3119	arylsulfatase activity
I6J55_RS19680	COG1119	ATPase activity
I6J55_RS19690	COG0588	phosphoglycerate mutase activity
I6J55_RS19695	COG1830	Aldolase
I6J55_RS19700	COG2205	protein histidine kinase activity
I6J55_RS19700	COG0745	RESPONSE REGULATOR receiver
I6J55_RS19700	COG3292	Two component regulator propeller
I6J55_RS19705	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS19710	COG3119	arylsulfatase activity
I6J55_RS19715	COG3119	arylsulfatase activity
I6J55_RS19720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J55_RS19725	COG3250	beta-galactosidase activity
I6J55_RS19740	COG0668	transmembrane transport
I6J55_RS19750	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J55_RS19790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J55_RS19850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J55_RS19855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J55_RS19860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J55_RS19865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J55_RS19870	COG0534	Mate efflux family protein
I6J55_RS19875	COG2202	Pas domain
I6J55_RS19875	COG2205	protein histidine kinase activity
I6J55_RS19900	COG1295	ribonuclease BN
I6J55_RS19910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J55_RS19945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J55_RS19950	COG0646	methionine synthase
I6J55_RS19950	COG1410	methionine synthase
I6J55_RS19960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J55_RS19970	COG0572	uridine kinase
I6J55_RS19980	COG4232	protein-disulfide reductase activity
I6J55_RS19985	COG1741	Belongs to the pirin family
I6J55_RS19995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J55_RS20000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J55_RS20010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J55_RS20010	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J55_RS20025	COG4206	TonB-dependent receptor
I6J55_RS20025	COG1629	transport
I6J55_RS20035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J55_RS20035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J55_RS20040	COG0339	signal peptide processing
I6J55_RS20045	COG3152	Membrane
I6J55_RS20055	COG1592	Rubrerythrin
I6J55_RS20055	COG1773	rubredoxin
I6J55_RS20090	COG3591	Belongs to the peptidase S1B family
I6J55_RS20095	COG3591	Belongs to the peptidase S1B family
I6J55_RS20100	COG0641	radical SAM
I6J55_RS20195	COG0681	Belongs to the peptidase S26 family
I6J55_RS20205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J55_RS20210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J55_RS20230	COG0420	3'-5' exonuclease activity
I6J55_RS20245	COG1132	(ABC) transporter
I6J55_RS20250	COG1132	(ABC) transporter
I6J55_RS20255	COG1408	metallophosphoesterase
I6J55_RS20300	COG0646	methionine synthase
I6J55_RS20300	COG1410	methionine synthase
I6J55_RS20310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J55_RS20315	COG0463	Glycosyl transferase, family 2
I6J55_RS20320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J55_RS20325	COG1032	radical SAM domain protein
I6J55_RS20365	COG0363	glucosamine-6-phosphate deaminase activity
I6J55_RS20375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J55_RS20425	COG4206	TonB-dependent receptor
I6J55_RS20425	COG1629	transport
I6J55_RS20430	COG0561	phosphatase activity
I6J55_RS20460	COG1090	epimerase
I6J55_RS20475	COG2207	Transcriptional regulator
I6J55_RS20480	COG1028	Short-chain dehydrogenase reductase Sdr
I6J55_RS20485	COG2814	Major facilitator Superfamily
I6J55_RS20490	COG1917	Cupin 2, conserved barrel domain protein
I6J55_RS20490	COG4977	sequence-specific DNA binding
I6J55_RS20540	COG0494	nUDIX hydrolase
I6J55_RS20550	COG0693	protein deglycase activity
I6J55_RS20565	COG4771	TonB-dependent receptor
I6J55_RS20570	COG0702	epimerase
I6J55_RS20575	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J55_RS20585	COG5012	cobalamin binding
I6J55_RS20595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J55_RS20600	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J55_RS20630	COG3586	endonuclease activity
I6J55_RS20650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J55_RS20660	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J55_RS20660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J55_RS20665	COG2884	Cell division ATP-binding protein ftsE
I6J55_RS20670	COG0527	aspartate kinase activity
I6J55_RS20675	COG0019	diaminopimelate decarboxylase activity
I6J55_RS20765	COG0156	8-amino-7-oxononanoate synthase activity
I6J55_RS20770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS20785	COG0321	lipoyl(octanoyl) transferase activity
I6J55_RS20785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J55_RS20800	COG0592	DNA-directed DNA polymerase activity
I6J55_RS20805	COG5002	protein histidine kinase activity
I6J55_RS20805	COG2176	DNA-directed DNA polymerase activity
I6J55_RS20815	COG0497	DNA recombination
I6J55_RS20820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J55_RS20840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J55_RS20865	COG2208	phosphoserine phosphatase activity
I6J55_RS20875	COG2172	sigma factor antagonist activity
I6J55_RS20890	COG5002	protein histidine kinase activity
I6J55_RS20955	COG0167	dihydroorotate dehydrogenase activity
I6J55_RS20960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J55_RS21010	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6J55_RS21060	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6J55_RS21090	COG0656	L-ascorbic acid biosynthetic process
I6J55_RS21100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J55_RS21115	COG0784	Response regulator, receiver
I6J55_RS21115	COG2205	protein histidine kinase activity
I6J55_RS21120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J55_RS21135	COG1192	Involved in chromosome partitioning
I6J55_RS21245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J55_RS21250	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J55_RS21280	COG0438	transferase activity, transferring glycosyl groups
I6J55_RS21290	COG1442	glycosyl transferase family 8
I6J55_RS21290	COG1216	Glycosyl transferase, family 2
I6J55_RS21305	COG0662	Cupin 2, conserved barrel domain protein
I6J55_RS21305	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6J55_RS21435	COG0629	single-stranded DNA binding
I6J55_RS21515	COG3385	transposase activity
I6J55_RS21520	COG4474	Belongs to the UPF0398 family
I6J55_RS21585	COG0776	regulation of translation
I6J55_RS21595	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6J55_RS21630	COG2003	Belongs to the UPF0758 family