locus-tag	class	description
GD630_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GD630_RS00020	COG1640	4-alpha-glucanotransferase
GD630_RS00030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GD630_RS00035	COG1803	Methylglyoxal synthase
GD630_RS00040	COG1216	Glycosyl transferase, family 2
GD630_RS00050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GD630_RS00055	COG4974	Belongs to the 'phage' integrase family
GD630_RS00090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GD630_RS00090	COG0551	DNA topoisomerase type I activity
GD630_RS00110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD630_RS00125	COG1538	Outer membrane efflux protein
GD630_RS00140	COG4974	Belongs to the 'phage' integrase family
GD630_RS00175	COG3392	D12 class N6 adenine-specific DNA methyltransferase
GD630_RS00265	COG0740	serine-type endopeptidase activity
GD630_RS00410	COG1022	Amp-dependent synthetase and ligase
GD630_RS00420	COG0359	binds to the 23S rRNA
GD630_RS00425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GD630_RS00430	COG0360	Binds together with S18 to 16S ribosomal RNA
GD630_RS00455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GD630_RS00460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GD630_RS00470	COG2431	L-lysine efflux transmembrane transporter activity
GD630_RS00480	COG4948	Mandelate Racemase Muconate Lactonizing
GD630_RS00510	COG4771	TonB-dependent receptor
GD630_RS00520	COG1595	DNA-templated transcription, initiation
GD630_RS00550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GD630_RS00555	COG0456	acetyltransferase
GD630_RS00570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GD630_RS00575	COG0802	atpase or kinase
GD630_RS00590	COG0714	Associated with various cellular activities
GD630_RS00625	COG3118	belongs to the thioredoxin family
GD630_RS00635	COG0688	phosphatidylethanolamine metabolic process
GD630_RS00640	COG1183	phosphatidylcholine synthase activity
GD630_RS00660	COG0792	nuclease activity
GD630_RS00685	COG0534	Mate efflux family protein
GD630_RS00690	COG0528	UMP kinase activity
GD630_RS00700	COG0233	cytoplasmic translational termination
GD630_RS00705	COG1162	GTPase activity
GD630_RS00715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GD630_RS00730	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GD630_RS00730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GD630_RS00740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GD630_RS00745	COG4974	Belongs to the 'phage' integrase family
GD630_RS00760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GD630_RS00770	COG1435	thymidine kinase activity
GD630_RS00775	COG0628	permease
GD630_RS00795	COG2198	Histidine kinase
GD630_RS00795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD630_RS00795	COG0784	Response regulator, receiver
GD630_RS00795	COG2205	protein histidine kinase activity
GD630_RS00800	COG2249	NAD(P)H dehydrogenase (quinone) activity
GD630_RS00805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GD630_RS00850	COG4974	Belongs to the 'phage' integrase family
GD630_RS00855	COG4974	Belongs to the 'phage' integrase family
GD630_RS00875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GD630_RS00880	COG2204	response regulator
GD630_RS00885	COG0446	pyridine nucleotide-disulphide oxidoreductase
GD630_RS00905	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS00910	COG0737	Belongs to the 5'-nucleotidase family
GD630_RS00915	COG0737	Belongs to the 5'-nucleotidase family
GD630_RS00920	COG0335	large ribosomal subunit rRNA binding
GD630_RS00925	COG1940	carbohydrate kinase activity
GD630_RS00930	COG1136	(ABC) transporter
GD630_RS00930	COG0577	efflux transmembrane transporter activity
GD630_RS00935	COG1136	(ABC) transporter
GD630_RS00935	COG0577	efflux transmembrane transporter activity
GD630_RS00940	COG0577	efflux transmembrane transporter activity
GD630_RS00940	COG1136	(ABC) transporter
GD630_RS00955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GD630_RS00955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GD630_RS00985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GD630_RS00990	COG3069	C4-dicarboxylate transmembrane transporter activity
GD630_RS01000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GD630_RS01015	COG2996	Protein conserved in bacteria
GD630_RS01020	COG0039	L-malate dehydrogenase activity
GD630_RS01030	COG2217	Heavy metal translocating P-type atpase
GD630_RS01055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GD630_RS01060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GD630_RS01065	COG0509	glycine decarboxylation via glycine cleavage system
GD630_RS01080	COG0006	proline dipeptidase activity
GD630_RS01095	COG1283	sodium-dependent phosphate transmembrane transporter activity
GD630_RS01110	COG1773	rubredoxin
GD630_RS01120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GD630_RS01125	COG1011	Hydrolase
GD630_RS01130	COG0196	riboflavin kinase activity
GD630_RS01135	COG1266	CAAX protease self-immunity
GD630_RS01145	COG0612	Peptidase, M16
GD630_RS01165	COG2166	iron-sulfur cluster assembly
GD630_RS01170	COG2234	aminopeptidase activity
GD630_RS01175	COG1619	proteins homologs of microcin C7 resistance protein MccF
GD630_RS01180	COG0280	phosphate acetyltransferase
GD630_RS01185	COG3426	butyrate kinase activity
GD630_RS01190	COG1185	polyribonucleotide nucleotidyltransferase activity
GD630_RS01200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GD630_RS01220	COG0076	glutamate decarboxylase activity
GD630_RS01225	COG2066	Belongs to the glutaminase family
GD630_RS01230	COG0531	amino acid
GD630_RS01325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GD630_RS01330	COG0470	DNA polymerase III
GD630_RS01335	COG1774	PSP1 C-terminal conserved region
GD630_RS01350	COG0772	Belongs to the SEDS family
GD630_RS01375	COG0138	bifunctional purine biosynthesis protein purh
GD630_RS01380	COG3590	peptidase
GD630_RS01385	COG0488	(ABC) transporter
GD630_RS01405	COG0784	Response regulator, receiver
GD630_RS01405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD630_RS01405	COG2198	Histidine kinase
GD630_RS01405	COG2205	protein histidine kinase activity
GD630_RS01410	COG0534	Mate efflux family protein
GD630_RS01415	COG0612	Peptidase, M16
GD630_RS01445	COG1629	transport
GD630_RS01445	COG4206	TonB-dependent receptor
GD630_RS01465	COG0745	RESPONSE REGULATOR receiver
GD630_RS01465	COG3292	Two component regulator propeller
GD630_RS01465	COG2205	protein histidine kinase activity
GD630_RS01470	COG3537	Alpha-1,2-mannosidase
GD630_RS01495	COG1595	DNA-templated transcription, initiation
GD630_RS01505	COG4771	TonB-dependent receptor
GD630_RS01535	COG0564	pseudouridine synthase activity
GD630_RS01560	COG3250	beta-galactosidase activity
GD630_RS01565	COG1501	Belongs to the glycosyl hydrolase 31 family
GD630_RS01595	COG0702	epimerase
GD630_RS01600	COG4771	TonB-dependent receptor
GD630_RS01605	COG3292	Two component regulator propeller
GD630_RS01605	COG2205	protein histidine kinase activity
GD630_RS01605	COG0745	RESPONSE REGULATOR receiver
GD630_RS01615	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS01635	COG0702	epimerase
GD630_RS01640	COG1629	transport
GD630_RS01660	COG1454	alcohol dehydrogenase
GD630_RS01665	COG0235	Class ii aldolase
GD630_RS01675	COG4806	L-rhamnose isomerase
GD630_RS01680	COG1070	Carbohydrate kinase
GD630_RS01685	COG1438	arginine binding
GD630_RS01695	COG0137	argininosuccinate synthase activity
GD630_RS01700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GD630_RS01705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GD630_RS01710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GD630_RS01715	COG1396	sequence-specific DNA binding
GD630_RS01715	COG1917	Cupin 2, conserved barrel domain protein
GD630_RS01720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GD630_RS01755	COG4771	TonB-dependent receptor
GD630_RS01790	COG4206	TonB-dependent receptor
GD630_RS01790	COG1629	transport
GD630_RS01815	COG0165	Argininosuccinate lyase
GD630_RS01825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GD630_RS01835	COG2890	protein-(glutamine-N5) methyltransferase activity
GD630_RS01840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD630_RS01840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD630_RS01850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GD630_RS01855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GD630_RS01870	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GD630_RS01880	COG0436	Aminotransferase
GD630_RS01885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GD630_RS01890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GD630_RS01895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GD630_RS01920	COG0564	pseudouridine synthase activity
GD630_RS01925	COG2815	serine threonine protein kinase
GD630_RS01925	COG0515	serine threonine protein kinase
GD630_RS01930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GD630_RS01935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GD630_RS01940	COG1785	Belongs to the alkaline phosphatase family
GD630_RS01950	COG1082	Xylose isomerase domain protein TIM barrel
GD630_RS01955	COG1629	transport
GD630_RS01955	COG4206	TonB-dependent receptor
GD630_RS01960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GD630_RS01995	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS02000	COG3119	arylsulfatase activity
GD630_RS02010	COG5492	domain, Protein
GD630_RS02015	COG0745	RESPONSE REGULATOR receiver
GD630_RS02015	COG2205	protein histidine kinase activity
GD630_RS02015	COG2205	protein histidine kinase activity
GD630_RS02015	COG3292	Two component regulator propeller
GD630_RS02015	COG0745	RESPONSE REGULATOR receiver
GD630_RS02015	COG3292	Two component regulator propeller
GD630_RS02020	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS02025	COG4771	TonB-dependent receptor
GD630_RS02035	COG1629	transport
GD630_RS02040	COG0702	epimerase
GD630_RS02055	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS02060	COG5492	domain, Protein
GD630_RS02065	COG5492	domain, Protein
GD630_RS02070	COG2003	Belongs to the UPF0758 family
GD630_RS02080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GD630_RS02085	COG0280	phosphate acetyltransferase
GD630_RS02090	COG1380	Effector of murein hydrolase LrgA
GD630_RS02095	COG1346	cytolysis
GD630_RS02135	COG0745	RESPONSE REGULATOR receiver
GD630_RS02135	COG2205	protein histidine kinase activity
GD630_RS02135	COG3292	Two component regulator propeller
GD630_RS02140	COG1501	Belongs to the glycosyl hydrolase 31 family
GD630_RS02150	COG4948	Mandelate Racemase Muconate Lactonizing
GD630_RS02170	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GD630_RS02175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GD630_RS02180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GD630_RS02190	COG0733	neurotransmitter:sodium symporter activity
GD630_RS02200	COG1136	(ABC) transporter
GD630_RS02205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GD630_RS02210	COG0475	glutathione-regulated potassium exporter activity
GD630_RS02210	COG0589	response to stress
GD630_RS02215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GD630_RS02225	COG1216	Glycosyl transferase, family 2
GD630_RS02225	COG0463	Glycosyl transferase, family 2
GD630_RS02235	COG2211	Major facilitator Superfamily
GD630_RS02245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GD630_RS02260	COG3292	Two component regulator propeller
GD630_RS02260	COG2205	protein histidine kinase activity
GD630_RS02260	COG0745	RESPONSE REGULATOR receiver
GD630_RS02265	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS02270	COG2382	esterase
GD630_RS02290	COG0702	epimerase
GD630_RS02305	COG4771	TonB-dependent receptor
GD630_RS02310	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS02315	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS02320	COG2382	esterase
GD630_RS02320	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS02320	COG3693	PFAM glycoside hydrolase, family 10
GD630_RS02330	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS02340	COG1373	ATPase (AAA superfamily
GD630_RS02345	COG1063	alcohol dehydrogenase
GD630_RS02350	COG0738	Major facilitator superfamily
GD630_RS02365	COG1609	Transcriptional regulator
GD630_RS02375	COG0423	glycine-tRNA ligase activity
GD630_RS02385	COG1609	Transcriptional regulator
GD630_RS02385	COG2207	Transcriptional regulator
GD630_RS02390	COG1629	transport
GD630_RS02410	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS02550	COG0740	serine-type endopeptidase activity
GD630_RS02655	COG3392	D12 class N6 adenine-specific DNA methyltransferase
GD630_RS02660	COG3344	reverse transcriptase
GD630_RS02815	COG3250	beta-galactosidase activity
GD630_RS02840	COG1760	l-serine dehydratase
GD630_RS02845	COG0598	Magnesium transport protein CorA
GD630_RS02850	COG1193	negative regulation of DNA recombination
GD630_RS02910	COG4804	nuclease activity
GD630_RS02935	COG4753	response regulator
GD630_RS02935	COG2207	Transcriptional regulator
GD630_RS02940	COG3189	MarR family transcriptional regulator
GD630_RS02945	COG0561	phosphatase activity
GD630_RS02950	COG1169	isochorismate synthase
GD630_RS02955	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GD630_RS02960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GD630_RS02965	COG4948	Mandelate Racemase Muconate Lactonizing
GD630_RS02975	COG1752	Esterase of the alpha-beta hydrolase superfamily
GD630_RS02990	COG1538	Outer membrane efflux protein
GD630_RS03000	COG3757	hydrolase, family 25
GD630_RS03015	COG0508	dehydrogenase complex catalyzes the overall conversion of
GD630_RS03020	COG0022	dehydrogenase e1 component
GD630_RS03030	COG2264	protein methyltransferase activity
GD630_RS03045	COG0590	tRNA wobble adenosine to inosine editing
GD630_RS03050	COG0673	inositol 2-dehydrogenase activity
GD630_RS03065	COG0702	epimerase
GD630_RS03070	COG4771	TonB-dependent receptor
GD630_RS03090	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS03095	COG0745	RESPONSE REGULATOR receiver
GD630_RS03095	COG2205	protein histidine kinase activity
GD630_RS03095	COG3292	Two component regulator propeller
GD630_RS03100	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GD630_RS03150	COG4771	TonB-dependent receptor
GD630_RS03175	COG1595	DNA-templated transcription, initiation
GD630_RS03185	COG1629	transport
GD630_RS03185	COG4206	TonB-dependent receptor
GD630_RS03220	COG0783	Belongs to the Dps family
GD630_RS03225	COG0583	DNA-binding transcription factor activity
GD630_RS03235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GD630_RS03265	COG1595	DNA-templated transcription, initiation
GD630_RS03275	COG4771	TonB-dependent receptor
GD630_RS03285	COG0584	glycerophosphoryl diester phosphodiesterase
GD630_RS03290	COG0584	glycerophosphoryl diester phosphodiesterase
GD630_RS03295	COG2271	Major facilitator Superfamily
GD630_RS03350	COG3023	N-Acetylmuramoyl-L-alanine amidase
GD630_RS03355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GD630_RS03365	COG1882	Formate acetyltransferase
GD630_RS03415	COG4804	nuclease activity
GD630_RS03425	COG4974	Belongs to the 'phage' integrase family
GD630_RS03555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD630_RS03555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD630_RS03610	COG4974	Belongs to the 'phage' integrase family
GD630_RS03615	COG1309	transcriptional regulator
GD630_RS03645	COG0745	RESPONSE REGULATOR receiver
GD630_RS03645	COG2205	protein histidine kinase activity
GD630_RS03645	COG3292	Two component regulator propeller
GD630_RS03655	COG1595	DNA-templated transcription, initiation
GD630_RS03660	COG1629	transport
GD630_RS03690	COG3250	beta-galactosidase activity
GD630_RS03700	COG3292	Two component regulator propeller
GD630_RS03700	COG0745	RESPONSE REGULATOR receiver
GD630_RS03700	COG2205	protein histidine kinase activity
GD630_RS03710	COG4206	TonB-dependent receptor
GD630_RS03710	COG1629	transport
GD630_RS03715	COG0561	phosphatase activity
GD630_RS03740	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS03755	COG1028	Short-chain dehydrogenase reductase Sdr
GD630_RS03760	COG0662	Cupin 2, conserved barrel domain protein
GD630_RS03760	COG2207	Transcriptional regulator
GD630_RS03770	COG4948	Mandelate Racemase Muconate Lactonizing
GD630_RS03810	COG4771	TonB-dependent receptor
GD630_RS03815	COG0702	epimerase
GD630_RS03830	COG5492	domain, Protein
GD630_RS03845	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS03855	COG1253	flavin adenine dinucleotide binding
GD630_RS03860	COG0501	Belongs to the peptidase M48B family
GD630_RS03885	COG0482	sulfurtransferase activity
GD630_RS03900	COG2197	response regulator
GD630_RS03920	COG4953	penicillin-binding protein 1C
GD630_RS03925	COG2373	Large extracellular alpha-helical protein
GD630_RS03940	COG4115	mRNA cleavage
GD630_RS03945	COG2161	toxin-antitoxin pair type II binding
GD630_RS03980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GD630_RS03985	COG1410	methionine synthase
GD630_RS03985	COG0646	methionine synthase
GD630_RS03995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GD630_RS04000	COG0572	uridine kinase
GD630_RS04010	COG4232	protein-disulfide reductase activity
GD630_RS04025	COG4771	TonB-dependent receptor
GD630_RS04030	COG0702	epimerase
GD630_RS04055	COG2271	Major facilitator Superfamily
GD630_RS04100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GD630_RS04105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GD630_RS04110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GD630_RS04115	COG0131	Imidazoleglycerol-phosphate dehydratase
GD630_RS04120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GD630_RS04120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GD630_RS04125	COG1629	transport
GD630_RS04125	COG4206	TonB-dependent receptor
GD630_RS04155	COG1404	Belongs to the peptidase S8 family
GD630_RS04175	COG1773	rubredoxin
GD630_RS04175	COG1592	Rubrerythrin
GD630_RS04190	COG3118	belongs to the thioredoxin family
GD630_RS04195	COG3591	Belongs to the peptidase S1B family
GD630_RS04200	COG3591	Belongs to the peptidase S1B family
GD630_RS04205	COG0641	radical SAM
GD630_RS04220	COG0420	3'-5' exonuclease activity
GD630_RS04240	COG1410	methionine synthase
GD630_RS04240	COG0646	methionine synthase
GD630_RS04245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GD630_RS04250	COG0463	Glycosyl transferase, family 2
GD630_RS04255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GD630_RS04270	COG1032	radical SAM domain protein
GD630_RS04290	COG0363	glucosamine-6-phosphate deaminase activity
GD630_RS04295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GD630_RS04330	COG0698	ribose 5-phosphate isomerase
GD630_RS04335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GD630_RS04355	COG2160	L-arabinose isomerase activity
GD630_RS04385	COG0702	epimerase
GD630_RS04390	COG4771	TonB-dependent receptor
GD630_RS04395	COG0702	epimerase
GD630_RS04400	COG1629	transport
GD630_RS04400	COG4206	TonB-dependent receptor
GD630_RS04410	COG2205	protein histidine kinase activity
GD630_RS04410	COG0745	RESPONSE REGULATOR receiver
GD630_RS04410	COG3292	Two component regulator propeller
GD630_RS04415	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS04425	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS04440	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GD630_RS04450	COG2017	converts alpha-aldose to the beta-anomer
GD630_RS04455	COG1482	cell wall glycoprotein biosynthetic process
GD630_RS04550	COG2244	polysaccharide biosynthetic process
GD630_RS04560	COG1442	glycosyl transferase family 8
GD630_RS04560	COG1216	Glycosyl transferase, family 2
GD630_RS04580	COG1215	transferase activity, transferring glycosyl groups
GD630_RS04585	COG1216	Glycosyl transferase, family 2
GD630_RS04595	COG3594	Acyltransferase
GD630_RS04650	COG0297	glycogen (starch) synthase activity
GD630_RS04655	COG0110	maltose O-acetyltransferase activity
GD630_RS04700	COG4221	oxidoreductase activity
GD630_RS04710	COG1218	3'(2'),5'-bisphosphate nucleotidase
GD630_RS04715	COG3273	potassium ion transport
GD630_RS04715	COG0471	metal ion transport
GD630_RS04720	COG0529	Catalyzes the synthesis of activated sulfate
GD630_RS04725	COG0175	sulfate reduction
GD630_RS04730	COG2895	sulfate adenylyltransferase (ATP) activity
GD630_RS04750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GD630_RS04755	COG0242	peptide deformylase activity
GD630_RS04765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GD630_RS04770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GD630_RS04775	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GD630_RS04780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GD630_RS04790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GD630_RS04795	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GD630_RS04800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GD630_RS04800	COG1013	pyruvate-flavodoxin oxidoreductase activity
GD630_RS04800	COG0674	pyruvate-flavodoxin oxidoreductase activity
GD630_RS04800	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GD630_RS04810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GD630_RS04820	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GD630_RS04830	COG1940	carbohydrate kinase activity
GD630_RS04840	COG2814	Major facilitator Superfamily
GD630_RS04855	COG4771	TonB-dependent receptor
GD630_RS04860	COG0702	epimerase
GD630_RS04880	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS04900	COG0673	inositol 2-dehydrogenase activity
GD630_RS04905	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS04925	COG4771	TonB-dependent receptor
GD630_RS04945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GD630_RS04950	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GD630_RS04955	COG4771	TonB-dependent receptor
GD630_RS04960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GD630_RS04965	COG4335	DNA alkylation repair
GD630_RS04970	COG0484	heat shock protein binding
GD630_RS04975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GD630_RS04980	COG0488	(ABC) transporter
GD630_RS05005	COG2183	response to ionizing radiation
GD630_RS05010	COG2205	protein histidine kinase activity
GD630_RS05010	COG2202	Pas domain
GD630_RS05015	COG0737	Belongs to the 5'-nucleotidase family
GD630_RS05050	COG0490	domain, Protein
GD630_RS05050	COG2985	domain, Protein
GD630_RS05055	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GD630_RS05065	COG0318	PFAM AMP-dependent synthetase and ligase
GD630_RS05070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GD630_RS05075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GD630_RS05085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GD630_RS05090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GD630_RS05095	COG0363	glucosamine-6-phosphate deaminase activity
GD630_RS05105	COG1595	DNA-templated transcription, initiation
GD630_RS05120	COG3279	Response regulator of the LytR AlgR family
GD630_RS05130	COG0577	efflux transmembrane transporter activity
GD630_RS05130	COG1136	(ABC) transporter
GD630_RS05135	COG1136	(ABC) transporter
GD630_RS05140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS05165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GD630_RS05170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GD630_RS05200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GD630_RS05205	COG2885	chlorophyll binding
GD630_RS05210	COG0534	Mate efflux family protein
GD630_RS05215	COG0657	acetylesterase activity
GD630_RS05215	COG2755	lipolytic protein G-D-S-L family
GD630_RS05225	COG0488	(ABC) transporter
GD630_RS05240	COG2205	protein histidine kinase activity
GD630_RS05240	COG0784	Response regulator, receiver
GD630_RS05265	COG2244	polysaccharide biosynthetic process
GD630_RS05300	COG3023	N-Acetylmuramoyl-L-alanine amidase
GD630_RS05355	COG1805	sodium ion transport
GD630_RS05360	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GD630_RS05375	COG2871	sodium ion transport
GD630_RS05395	COG0513	Belongs to the DEAD box helicase family
GD630_RS05400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GD630_RS05415	COG1739	Uncharacterized protein family UPF0029
GD630_RS05430	COG0778	Nitroreductase
GD630_RS05435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GD630_RS05435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GD630_RS05440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD630_RS05445	COG0357	Ribosomal RNA small subunit methyltransferase G
GD630_RS05465	COG1408	metallophosphoesterase
GD630_RS05485	COG2217	Heavy metal translocating P-type atpase
GD630_RS05490	COG3328	transposase activity
GD630_RS05500	COG0321	lipoyl(octanoyl) transferase activity
GD630_RS05530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GD630_RS05540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GD630_RS05555	COG1678	Uncharacterized ACR, COG1678
GD630_RS05605	COG0305	Participates in initiation and elongation during chromosome replication
GD630_RS05630	COG3969	phosphoadenosine phosphosulfate
GD630_RS05635	COG1475	DNA binding
GD630_RS05640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GD630_RS05700	COG1629	transport
GD630_RS05700	COG4206	TonB-dependent receptor
GD630_RS05710	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GD630_RS05715	COG3537	Alpha-1,2-mannosidase
GD630_RS05725	COG1629	transport
GD630_RS05725	COG4206	TonB-dependent receptor
GD630_RS05730	COG0702	epimerase
GD630_RS05755	COG3408	Glycogen debranching enzyme
GD630_RS05775	COG1028	Short-chain dehydrogenase reductase Sdr
GD630_RS05780	COG3408	Glycogen debranching enzyme
GD630_RS05790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS05800	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GD630_RS05805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GD630_RS05835	COG3250	beta-galactosidase activity
GD630_RS05840	COG3250	beta-galactosidase activity
GD630_RS05845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GD630_RS05870	COG3250	beta-galactosidase activity
GD630_RS05875	COG2205	protein histidine kinase activity
GD630_RS05875	COG3292	Two component regulator propeller
GD630_RS05875	COG0745	RESPONSE REGULATOR receiver
GD630_RS05900	COG2966	Psort location CytoplasmicMembrane, score
GD630_RS05915	COG0300	oxidoreductase activity
GD630_RS05920	COG1011	Hydrolase
GD630_RS05945	COG0745	RESPONSE REGULATOR receiver
GD630_RS05945	COG3292	Two component regulator propeller
GD630_RS05945	COG2205	protein histidine kinase activity
GD630_RS05945	COG3292	Two component regulator propeller
GD630_RS05945	COG0745	RESPONSE REGULATOR receiver
GD630_RS05945	COG2205	protein histidine kinase activity
GD630_RS05975	COG0442	prolyl-tRNA aminoacylation
GD630_RS05980	COG0745	RESPONSE REGULATOR receiver
GD630_RS05985	COG2205	protein histidine kinase activity
GD630_RS06070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GD630_RS06080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GD630_RS06085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GD630_RS06095	COG0552	protein localization to endoplasmic reticulum
GD630_RS06100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GD630_RS06115	COG0714	Associated with various cellular activities
GD630_RS06130	COG2304	oxidoreductase activity
GD630_RS06170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GD630_RS06175	COG0542	response to heat
GD630_RS06180	COG0326	Molecular chaperone. Has ATPase activity
GD630_RS06185	COG1752	Esterase of the alpha-beta hydrolase superfamily
GD630_RS06205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GD630_RS06210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GD630_RS06215	COG0336	Belongs to the RNA methyltransferase TrmD family
GD630_RS06220	COG0167	dihydroorotate dehydrogenase activity
GD630_RS06225	COG0543	2 iron, 2 sulfur cluster binding
GD630_RS06240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GD630_RS06255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS06260	COG1538	Outer membrane efflux protein
GD630_RS06320	COG2957	Belongs to the agmatine deiminase family
GD630_RS06335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GD630_RS06340	COG1597	lipid kinase activity
GD630_RS06345	COG0156	8-amino-7-oxononanoate synthase activity
GD630_RS06365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GD630_RS06370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GD630_RS06390	COG0560	Phosphoserine phosphatase
GD630_RS06390	COG3830	Belongs to the UPF0237 family
GD630_RS06395	COG0513	Belongs to the DEAD box helicase family
GD630_RS06460	COG0246	Mannitol dehydrogenase
GD630_RS06470	COG1904	glucuronate isomerase
GD630_RS06485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GD630_RS06525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GD630_RS06540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GD630_RS06550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GD630_RS06560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GD630_RS06560	COG3153	acetyltransferase
GD630_RS06600	COG0477	Major facilitator Superfamily
GD630_RS06600	COG2814	Major facilitator Superfamily
GD630_RS06605	COG2115	Belongs to the xylose isomerase family
GD630_RS06620	COG0352	thiamine-phosphate diphosphorylase activity
GD630_RS06620	COG0351	phosphomethylpyrimidine kinase
GD630_RS06625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GD630_RS06655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GD630_RS06660	COG2731	YhcH YjgK YiaL family protein
GD630_RS06690	COG2205	protein histidine kinase activity
GD630_RS06695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GD630_RS06710	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GD630_RS06720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GD630_RS06750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GD630_RS06755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GD630_RS06770	COG0438	transferase activity, transferring glycosyl groups
GD630_RS06790	COG0438	transferase activity, transferring glycosyl groups
GD630_RS06800	COG0438	transferase activity, transferring glycosyl groups
GD630_RS06805	COG0438	transferase activity, transferring glycosyl groups
GD630_RS06810	COG1216	Glycosyl transferase, family 2
GD630_RS06810	COG1442	glycosyl transferase family 8
GD630_RS06815	COG1045	serine acetyltransferase
GD630_RS06840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GD630_RS06850	COG1086	Polysaccharide biosynthesis protein
GD630_RS06880	COG0540	Belongs to the ATCase OTCase family
GD630_RS06885	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GD630_RS06900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GD630_RS06905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GD630_RS06910	COG2985	domain, Protein
GD630_RS06925	COG2207	Transcriptional regulator
GD630_RS06930	COG2755	lipolytic protein G-D-S-L family
GD630_RS06930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GD630_RS06935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GD630_RS06945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GD630_RS06950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GD630_RS06955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GD630_RS06960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GD630_RS06965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GD630_RS06970	COG0356	it plays a direct role in the translocation of protons across the membrane
GD630_RS06985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GD630_RS06990	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GD630_RS07020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GD630_RS07030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GD630_RS07035	COG1011	Hydrolase
GD630_RS07040	COG0534	Mate efflux family protein
GD630_RS07060	COG1151	hydroxylamine reductase activity
GD630_RS07065	COG3263	regulation of cellular component size
GD630_RS07070	COG1022	Amp-dependent synthetase and ligase
GD630_RS07075	COG1082	Xylose isomerase domain protein TIM barrel
GD630_RS07155	COG0681	Belongs to the peptidase S26 family
GD630_RS07235	COG0352	thiamine-phosphate diphosphorylase activity
GD630_RS07240	COG2022	thiamine diphosphate biosynthetic process
GD630_RS07245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GD630_RS07250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GD630_RS07255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GD630_RS07260	COG0352	thiamine-phosphate diphosphorylase activity
GD630_RS07270	COG0574	Belongs to the PEP-utilizing enzyme family
GD630_RS07270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GD630_RS07275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GD630_RS07280	COG0564	pseudouridine synthase activity
GD630_RS07315	COG0024	Methionine aminopeptidase
GD630_RS07330	COG0481	GTPase activity
GD630_RS07345	COG0708	Exodeoxyribonuclease III
GD630_RS07360	COG0217	transcriptional regulatory protein
GD630_RS07365	COG0072	phenylalanine-tRNA ligase activity
GD630_RS07365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GD630_RS07370	COG0305	Participates in initiation and elongation during chromosome replication
GD630_RS07375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GD630_RS07380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GD630_RS07385	COG4657	Part of a membrane complex involved in electron transport
GD630_RS07390	COG4660	Part of a membrane complex involved in electron transport
GD630_RS07395	COG4659	FMN binding
GD630_RS07400	COG4658	electron transport chain
GD630_RS07405	COG4656	Part of a membrane complex involved in electron transport
GD630_RS07505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GD630_RS07510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GD630_RS07520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GD630_RS07530	COG1442	glycosyl transferase family 8
GD630_RS07530	COG1216	Glycosyl transferase, family 2
GD630_RS07545	COG1215	transferase activity, transferring glycosyl groups
GD630_RS07590	COG1216	Glycosyl transferase, family 2
GD630_RS07610	COG1442	glycosyl transferase family 8
GD630_RS07610	COG1216	Glycosyl transferase, family 2
GD630_RS07620	COG3206	protein involved in exopolysaccharide biosynthesis
GD630_RS07620	COG0489	protein tyrosine kinase activity
GD630_RS07675	COG0504	CTP synthase activity
GD630_RS07680	COG0706	membrane insertase activity
GD630_RS07685	COG0534	Mate efflux family protein
GD630_RS07690	COG1506	peptidase
GD630_RS07690	COG0823	Involved in the tonB-independent uptake of proteins
GD630_RS07705	COG4974	Belongs to the 'phage' integrase family
GD630_RS07750	COG1983	PspC domain protein
GD630_RS07770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GD630_RS07780	COG1388	LysM domain
GD630_RS07780	COG3942	CHAP domain
GD630_RS07810	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GD630_RS07815	COG0556	nucleotide-excision repair
GD630_RS07825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GD630_RS07840	COG0842	Transport permease protein
GD630_RS07845	COG0842	Transport permease protein
GD630_RS07850	COG1131	(ABC) transporter
GD630_RS07855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS07865	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GD630_RS07865	COG0662	Cupin 2, conserved barrel domain protein
GD630_RS07870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GD630_RS07875	COG0505	Belongs to the CarA family
GD630_RS07885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GD630_RS07890	COG0069	glutamate synthase activity
GD630_RS07890	COG0070	glutamate synthase
GD630_RS07890	COG0067	glutamate synthase
GD630_RS07900	COG0367	asparagine synthase
GD630_RS07915	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GD630_RS07920	COG0436	Aminotransferase
GD630_RS07930	COG0347	Belongs to the P(II) protein family
GD630_RS07935	COG0004	ammonium transporteR
GD630_RS07960	COG1979	alcohol dehydrogenase
GD630_RS07970	COG0133	tryptophan synthase activity
GD630_RS07975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GD630_RS07985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GD630_RS07990	COG0134	indole-3-glycerol-phosphate synthase activity
GD630_RS07995	COG0135	phosphoribosylanthranilate isomerase activity
GD630_RS08000	COG0159	tryptophan synthase activity
GD630_RS08005	COG0252	asparaginase activity
GD630_RS08010	COG0745	RESPONSE REGULATOR receiver
GD630_RS08015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GD630_RS08025	COG0110	maltose O-acetyltransferase activity
GD630_RS08035	COG2197	response regulator
GD630_RS08045	COG0138	bifunctional purine biosynthesis protein purh
GD630_RS08060	COG1730	sister chromatid segregation
GD630_RS08065	COG3487	Iron-regulated protein
GD630_RS08090	COG1333	cytochrome c biogenesis protein
GD630_RS08090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GD630_RS08100	COG1132	(ABC) transporter
GD630_RS08105	COG1132	(ABC) transporter
GD630_RS08110	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GD630_RS08155	COG4771	TonB-dependent receptor
GD630_RS08165	COG0490	domain, Protein
GD630_RS08165	COG2985	domain, Protein
GD630_RS08175	COG4771	TonB-dependent receptor
GD630_RS08210	COG1609	Transcriptional regulator
GD630_RS08215	COG2721	sulfolactate sulfo-lyase activity
GD630_RS08230	COG4452	Inner membrane protein CreD
GD630_RS08240	COG1733	regulation of RNA biosynthetic process
GD630_RS08250	COG0784	Response regulator, receiver
GD630_RS08250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD630_RS08250	COG2198	Histidine kinase
GD630_RS08250	COG2205	protein histidine kinase activity
GD630_RS08260	COG3275	phosphorelay sensor kinase activity
GD630_RS08285	COG0228	four-way junction DNA binding
GD630_RS08295	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
GD630_RS08305	COG1070	Carbohydrate kinase
GD630_RS08310	COG0738	Major facilitator superfamily
GD630_RS08335	COG1177	transmembrane transport
GD630_RS08340	COG1176	ABC-type spermidine putrescine transport system, permease component I
GD630_RS08345	COG3842	ATPase activity
GD630_RS08350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GD630_RS08355	COG0058	SHG alpha-glucan phosphorylase activity
GD630_RS08365	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GD630_RS08385	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GD630_RS08435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GD630_RS08440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GD630_RS08445	COG4948	Mandelate Racemase Muconate Lactonizing
GD630_RS08460	COG1295	ribonuclease BN
GD630_RS08465	COG0778	Nitroreductase
GD630_RS08480	COG0704	Plays a role in the regulation of phosphate uptake
GD630_RS08485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GD630_RS08490	COG0581	inorganic phosphate transmembrane transporter activity
GD630_RS08495	COG0573	inorganic phosphate transmembrane transporter activity
GD630_RS08505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GD630_RS08515	COG0586	Pfam SNARE associated Golgi protein
GD630_RS08520	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GD630_RS08535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GD630_RS08540	COG0167	dihydroorotate dehydrogenase activity
GD630_RS08545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GD630_RS08570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GD630_RS08575	COG0497	DNA recombination
GD630_RS08590	COG0592	DNA-directed DNA polymerase activity
GD630_RS08610	COG0321	lipoyl(octanoyl) transferase activity
GD630_RS08610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GD630_RS08615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GD630_RS08625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GD630_RS08630	COG0156	8-amino-7-oxononanoate synthase activity
GD630_RS08645	COG0019	diaminopimelate decarboxylase activity
GD630_RS08650	COG0527	aspartate kinase activity
GD630_RS08655	COG2884	Cell division ATP-binding protein ftsE
GD630_RS08660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GD630_RS08660	COG0140	phosphoribosyl-ATP diphosphatase activity
GD630_RS08665	COG0107	imidazoleglycerol-phosphate synthase activity
GD630_RS08670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GD630_RS08675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GD630_RS08680	COG0788	formyltetrahydrofolate deformylase activity
GD630_RS08700	COG0110	maltose O-acetyltransferase activity
GD630_RS08715	COG1983	PspC domain protein
GD630_RS08720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GD630_RS08740	COG0037	tRNA processing
GD630_RS08755	COG4864	UPF0365 protein
GD630_RS08765	COG0784	Response regulator, receiver
GD630_RS08765	COG2205	protein histidine kinase activity
GD630_RS08770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GD630_RS08780	COG4974	Belongs to the 'phage' integrase family
GD630_RS08880	COG0534	Mate efflux family protein
GD630_RS08890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GD630_RS08905	COG3831	ATPase activity
GD630_RS08905	COG4884	unkown
GD630_RS08915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GD630_RS08925	COG1506	peptidase
GD630_RS08925	COG4946	Tricorn protease homolog
GD630_RS08925	COG0823	Involved in the tonB-independent uptake of proteins
GD630_RS08935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GD630_RS08940	COG3275	phosphorelay sensor kinase activity
GD630_RS09000	COG1312	Catalyzes the dehydration of D-mannonate
GD630_RS09005	COG1028	Short-chain dehydrogenase reductase Sdr
GD630_RS09010	COG1609	Transcriptional regulator
GD630_RS09025	COG2223	nitrite transmembrane transporter activity
GD630_RS09040	COG4771	TonB-dependent receptor
GD630_RS09050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GD630_RS09050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GD630_RS09065	COG2226	methyltransferase
GD630_RS09075	COG0784	Response regulator, receiver
GD630_RS09075	COG2205	protein histidine kinase activity
GD630_RS09075	COG5002	protein histidine kinase activity
GD630_RS09080	COG1620	l-lactate permease
GD630_RS09095	COG0628	permease
GD630_RS09100	COG1215	transferase activity, transferring glycosyl groups
GD630_RS09105	COG1136	(ABC) transporter
GD630_RS09105	COG0577	efflux transmembrane transporter activity
GD630_RS09110	COG0436	Aminotransferase
GD630_RS09155	COG4771	TonB-dependent receptor
GD630_RS09160	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS09165	COG2205	protein histidine kinase activity
GD630_RS09165	COG3292	Two component regulator propeller
GD630_RS09165	COG2205	protein histidine kinase activity
GD630_RS09165	COG0745	RESPONSE REGULATOR receiver
GD630_RS09165	COG3292	Two component regulator propeller
GD630_RS09165	COG0745	RESPONSE REGULATOR receiver
GD630_RS09180	COG0488	(ABC) transporter
GD630_RS09195	COG0745	RESPONSE REGULATOR receiver
GD630_RS09200	COG5002	protein histidine kinase activity
GD630_RS09205	COG4206	TonB-dependent receptor
GD630_RS09225	COG1674	ftsk spoiiie
GD630_RS09255	COG0629	single-stranded DNA binding
GD630_RS09260	COG1194	a g-specific adenine glycosylase
GD630_RS09270	COG1530	ribonuclease E activity
GD630_RS09315	COG1252	NADH dehydrogenase
GD630_RS09320	COG1705	Flagellar rod assembly protein muramidase FlgJ
GD630_RS09355	COG0295	cytidine deaminase activity
GD630_RS09365	COG3059	membrane
GD630_RS09370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GD630_RS09375	COG0488	(ABC) transporter
GD630_RS09390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GD630_RS09405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GD630_RS09410	COG4206	TonB-dependent receptor
GD630_RS09410	COG1629	transport
GD630_RS09430	COG4753	response regulator
GD630_RS09430	COG2207	Transcriptional regulator
GD630_RS09460	COG1595	DNA-templated transcription, initiation
GD630_RS09475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GD630_RS09490	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GD630_RS09495	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GD630_RS09510	COG1595	DNA-templated transcription, initiation
GD630_RS09525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GD630_RS09530	COG1741	Belongs to the pirin family
GD630_RS09535	COG0259	pyridoxamine-phosphate oxidase activity
GD630_RS09550	COG0346	lactoylglutathione lyase activity
GD630_RS09595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GD630_RS09595	COG1918	ferrous iron import across plasma membrane
GD630_RS09600	COG0037	tRNA processing
GD630_RS09615	COG3119	arylsulfatase activity
GD630_RS09620	COG2202	Pas domain
GD630_RS09620	COG2205	protein histidine kinase activity
GD630_RS09625	COG2205	protein histidine kinase activity
GD630_RS09630	COG0534	Mate efflux family protein
GD630_RS09635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GD630_RS09640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GD630_RS09665	COG1063	alcohol dehydrogenase
GD630_RS09670	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GD630_RS09690	COG4974	Belongs to the 'phage' integrase family
GD630_RS09710	COG0732	type I restriction modification DNA specificity domain
GD630_RS09715	COG0732	type I restriction modification DNA specificity domain
GD630_RS09725	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GD630_RS09730	COG1401	restriction endodeoxyribonuclease activity
GD630_RS09735	COG4268	DNA restriction-modification system
GD630_RS09750	COG0653	protein targeting
GD630_RS09760	COG0346	lactoylglutathione lyase activity
GD630_RS09770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GD630_RS09790	COG0564	pseudouridine synthase activity
GD630_RS09795	COG0534	Mate efflux family protein
GD630_RS09830	COG0741	lytic transglycosylase activity
GD630_RS09830	COG1388	LysM domain
GD630_RS09835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GD630_RS09845	COG1285	pathogenesis
GD630_RS09900	COG2233	PERMEase
GD630_RS09915	COG4771	TonB-dependent receptor
GD630_RS09925	COG1393	Belongs to the ArsC family
GD630_RS09935	COG2304	oxidoreductase activity
GD630_RS09945	COG4589	Belongs to the CDS family
GD630_RS09960	COG4771	TonB-dependent receptor
GD630_RS09965	COG0351	phosphomethylpyrimidine kinase
GD630_RS09975	COG1139	Iron-sulfur cluster binding protein
GD630_RS09980	COG0247	lactate metabolic process
GD630_RS09985	COG2832	Protein of unknown function (DUF454)
GD630_RS09990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GD630_RS10000	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GD630_RS10005	COG0714	Associated with various cellular activities
GD630_RS10040	COG1418	mRNA catabolic process
GD630_RS10045	COG3142	Participates in the control of copper homeostasis
GD630_RS10115	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS10130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GD630_RS10135	COG0563	adenylate kinase activity
GD630_RS10145	COG3104	oligopeptide transport
GD630_RS10150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GD630_RS10150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GD630_RS10190	COG2204	response regulator
GD630_RS10195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GD630_RS10205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GD630_RS10215	COG1253	flavin adenine dinucleotide binding
GD630_RS10235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GD630_RS10250	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
GD630_RS10255	COG0653	protein targeting
GD630_RS10295	COG1629	transport
GD630_RS10305	COG1595	DNA-templated transcription, initiation
GD630_RS10310	COG0525	valine-tRNA ligase activity
GD630_RS10335	COG3152	Membrane
GD630_RS10345	COG3956	TIGRFAM MazG family protein
GD630_RS10365	COG2989	Protein conserved in bacteria
GD630_RS10370	COG1234	tRNA 3'-trailer cleavage
GD630_RS10420	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GD630_RS10420	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GD630_RS10525	COG4206	TonB-dependent receptor
GD630_RS10525	COG1629	transport
GD630_RS10560	COG3118	belongs to the thioredoxin family
GD630_RS10565	COG0492	ferredoxin-NADP+ reductase activity
GD630_RS10575	COG1674	ftsk spoiiie
GD630_RS10590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GD630_RS10595	COG2211	Major facilitator Superfamily
GD630_RS10615	COG1136	(ABC) transporter
GD630_RS10630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GD630_RS10635	COG1597	lipid kinase activity
GD630_RS10640	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GD630_RS10645	COG0612	Peptidase, M16
GD630_RS10660	COG0791	NLP P60 protein
GD630_RS10670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GD630_RS10675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GD630_RS10680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GD630_RS10685	COG0543	2 iron, 2 sulfur cluster binding
GD630_RS10690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GD630_RS10695	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GD630_RS10700	COG0297	glycogen (starch) synthase activity
GD630_RS10715	COG0297	glycogen (starch) synthase activity
GD630_RS10725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GD630_RS10730	COG0793	Belongs to the peptidase S41A family
GD630_RS10755	COG4206	TonB-dependent receptor
GD630_RS10755	COG1629	transport
GD630_RS10780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GD630_RS10780	COG0519	Catalyzes the synthesis of GMP from XMP
GD630_RS10785	COG1970	mechanosensitive ion channel activity
GD630_RS10795	COG0339	signal peptide processing
GD630_RS10805	COG2131	deaminase
GD630_RS10810	COG0793	Belongs to the peptidase S41A family
GD630_RS10825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GD630_RS10835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GD630_RS10850	COG0673	inositol 2-dehydrogenase activity
GD630_RS10855	COG5434	Belongs to the glycosyl hydrolase 28 family
GD630_RS10870	COG1629	transport
GD630_RS10895	COG0673	inositol 2-dehydrogenase activity
GD630_RS10900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD630_RS10905	COG3250	beta-galactosidase activity
GD630_RS10925	COG0101	tRNA pseudouridine synthase activity
GD630_RS10935	COG2268	Band 7 protein
GD630_RS10945	COG1702	phosphate starvation-inducible protein PhoH
GD630_RS10950	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GD630_RS10955	COG2226	methyltransferase
GD630_RS10960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GD630_RS10975	COG1704	LemA family
GD630_RS10985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GD630_RS10990	COG0284	orotidine-5'-phosphate decarboxylase activity
GD630_RS10995	COG1078	dGTPase activity
GD630_RS11000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GD630_RS11005	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GD630_RS11005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GD630_RS11020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GD630_RS11030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GD630_RS11040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GD630_RS11050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GD630_RS11060	COG3292	Two component regulator propeller
GD630_RS11060	COG2205	protein histidine kinase activity
GD630_RS11060	COG0745	RESPONSE REGULATOR receiver
GD630_RS11065	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS11085	COG4677	pectinesterase activity
GD630_RS11100	COG0702	epimerase
GD630_RS11105	COG4206	TonB-dependent receptor
GD630_RS11105	COG1629	transport
GD630_RS11155	COG4733	cellulase activity
GD630_RS11190	COG3401	FG-GAP repeat protein
GD630_RS11205	COG3292	Two component regulator propeller
GD630_RS11205	COG0745	RESPONSE REGULATOR receiver
GD630_RS11205	COG2205	protein histidine kinase activity
GD630_RS11205	COG2205	protein histidine kinase activity
GD630_RS11205	COG0745	RESPONSE REGULATOR receiver
GD630_RS11205	COG3292	Two component regulator propeller
GD630_RS11210	COG3250	beta-galactosidase activity
GD630_RS11220	COG1629	transport
GD630_RS11230	COG3328	transposase activity
GD630_RS11255	COG2755	lipolytic protein G-D-S-L family
GD630_RS11270	COG3250	beta-galactosidase activity
GD630_RS11285	COG0745	RESPONSE REGULATOR receiver
GD630_RS11285	COG2205	protein histidine kinase activity
GD630_RS11285	COG0745	RESPONSE REGULATOR receiver
GD630_RS11285	COG3292	Two component regulator propeller
GD630_RS11285	COG3292	Two component regulator propeller
GD630_RS11285	COG2205	protein histidine kinase activity
GD630_RS11290	COG2755	lipolytic protein G-D-S-L family
GD630_RS11295	COG3401	FG-GAP repeat protein
GD630_RS11305	COG4771	TonB-dependent receptor
GD630_RS11310	COG0561	phosphatase activity
GD630_RS11315	COG1629	transport
GD630_RS11315	COG4206	TonB-dependent receptor
GD630_RS11345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GD630_RS11350	COG0561	phosphatase activity
GD630_RS11355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GD630_RS11365	COG0009	L-threonylcarbamoyladenylate synthase
GD630_RS11370	COG0363	glucosamine-6-phosphate deaminase activity
GD630_RS11380	COG1242	4 iron, 4 sulfur cluster binding
GD630_RS11385	COG1629	transport
GD630_RS11385	COG4206	TonB-dependent receptor
GD630_RS11410	COG3292	Two component regulator propeller
GD630_RS11410	COG0745	RESPONSE REGULATOR receiver
GD630_RS11410	COG2205	protein histidine kinase activity
GD630_RS11415	COG2755	lipolytic protein G-D-S-L family
GD630_RS11420	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS11425	COG3775	system Galactitol-specific IIC component
GD630_RS11430	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GD630_RS11435	COG2271	Major facilitator Superfamily
GD630_RS11445	COG0805	protein transport
GD630_RS11450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GD630_RS11455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GD630_RS11465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GD630_RS11470	COG0569	domain protein
GD630_RS11475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GD630_RS11485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GD630_RS11490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GD630_RS11495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GD630_RS11495	COG0649	NAD binding
GD630_RS11500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GD630_RS11515	COG0713	ATP synthesis coupled electron transport
GD630_RS11520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GD630_RS11525	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GD630_RS11545	COG2207	Transcriptional regulator
GD630_RS11545	COG0662	Cupin 2, conserved barrel domain protein
GD630_RS11550	COG0668	transmembrane transport
GD630_RS11585	COG2195	Cleaves the N-terminal amino acid of tripeptides
GD630_RS11595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GD630_RS11600	COG2239	Acts as a magnesium transporter
GD630_RS11605	COG1196	nuclear chromosome segregation
GD630_RS11620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GD630_RS11625	COG4589	Belongs to the CDS family
GD630_RS11635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GD630_RS11640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GD630_RS11650	COG1192	Involved in chromosome partitioning
GD630_RS11655	COG1475	DNA binding
GD630_RS11665	COG0741	lytic transglycosylase activity
GD630_RS11665	COG1388	LysM domain
GD630_RS11670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GD630_RS11680	COG0739	heme binding
GD630_RS11685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GD630_RS11705	COG3537	Alpha-1,2-mannosidase
GD630_RS11710	COG3537	Alpha-1,2-mannosidase
GD630_RS11745	COG4771	TonB-dependent receptor
GD630_RS11770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GD630_RS11790	COG4974	Belongs to the 'phage' integrase family
GD630_RS11795	COG4974	Belongs to the 'phage' integrase family
GD630_RS11865	COG2205	protein histidine kinase activity
GD630_RS11865	COG2198	Histidine kinase
GD630_RS11865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD630_RS11865	COG0784	Response regulator, receiver
GD630_RS11885	COG0358	DNA primase activity
GD630_RS11920	COG0742	ribosomal rna small subunit methyltransferase
GD630_RS11925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GD630_RS11940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GD630_RS11955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GD630_RS11965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GD630_RS11975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GD630_RS11980	COG2333	competence protein COMEC
GD630_RS11980	COG0658	competence protein
GD630_RS11985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GD630_RS11990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GD630_RS12000	COG0009	L-threonylcarbamoyladenylate synthase
GD630_RS12010	COG1785	Belongs to the alkaline phosphatase family
GD630_RS12030	COG0702	epimerase
GD630_RS12035	COG4771	TonB-dependent receptor
GD630_RS12050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GD630_RS12050	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GD630_RS12055	COG0514	ATP-dependent DNA helicase (RecQ)
GD630_RS12075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GD630_RS12085	COG0358	DNA primase activity
GD630_RS12090	COG0302	gtp cyclohydrolase
GD630_RS12100	COG0149	triose-phosphate isomerase activity
GD630_RS12110	COG0739	heme binding
GD630_RS12115	COG0105	UTP biosynthetic process
GD630_RS12120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GD630_RS12125	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GD630_RS12140	COG0848	biopolymer transport protein
GD630_RS12145	COG0811	peptide transport
GD630_RS12150	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GD630_RS12155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GD630_RS12190	COG4771	TonB-dependent receptor
GD630_RS12205	COG0039	L-malate dehydrogenase activity
GD630_RS12215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS12235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GD630_RS12240	COG0489	protein tyrosine kinase activity
GD630_RS12245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GD630_RS12250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GD630_RS12260	COG1570	exodeoxyribonuclease VII activity
GD630_RS12270	COG0482	sulfurtransferase activity
GD630_RS12280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GD630_RS12285	COG0179	Fumarylacetoacetate (FAA) hydrolase
GD630_RS12290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GD630_RS12300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GD630_RS12305	COG0052	Belongs to the universal ribosomal protein uS2 family
GD630_RS12310	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GD630_RS12315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GD630_RS12320	COG4771	TonB-dependent receptor
GD630_RS12325	COG0702	epimerase
GD630_RS12365	COG3119	arylsulfatase activity
GD630_RS12370	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS12375	COG3292	Two component regulator propeller
GD630_RS12375	COG2205	protein histidine kinase activity
GD630_RS12375	COG0745	RESPONSE REGULATOR receiver
GD630_RS12380	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS12400	COG0017	Asparaginyl-tRNA synthetase
GD630_RS12405	COG1187	pseudouridine synthase activity
GD630_RS12425	COG0110	maltose O-acetyltransferase activity
GD630_RS12430	COG3022	response to hydroperoxide
GD630_RS12460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GD630_RS12475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GD630_RS12485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GD630_RS12490	COG0516	GMP reductase activity
GD630_RS12490	COG0517	IMP dehydrogenase activity
GD630_RS12495	COG0514	ATP-dependent DNA helicase (RecQ)
GD630_RS12500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GD630_RS12505	COG0740	serine-type endopeptidase activity
GD630_RS12510	COG0544	peptidyl-prolyl cis-trans isomerase activity
GD630_RS12515	COG0724	RNA recognition motif
GD630_RS12520	COG1127	ABC transporter
GD630_RS12525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GD630_RS12535	COG1160	GTP binding
GD630_RS12540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GD630_RS12545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GD630_RS12625	COG0589	response to stress
GD630_RS12625	COG0475	glutathione-regulated potassium exporter activity
GD630_RS12630	COG0534	Mate efflux family protein
GD630_RS12640	COG1522	sequence-specific DNA binding
GD630_RS12655	COG0668	transmembrane transport
GD630_RS12680	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GD630_RS12685	COG0527	aspartate kinase activity
GD630_RS12685	COG0460	homoserine dehydrogenase
GD630_RS12690	COG0252	asparaginase activity
GD630_RS12695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GD630_RS12705	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GD630_RS12715	COG4771	TonB-dependent receptor
GD630_RS12725	COG0826	peptidase U32
GD630_RS12730	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GD630_RS12740	COG0436	Aminotransferase
GD630_RS12745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GD630_RS12800	COG3328	transposase activity
GD630_RS12830	COG4974	Belongs to the 'phage' integrase family
GD630_RS12855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GD630_RS12915	COG4771	TonB-dependent receptor
GD630_RS12960	COG0519	Catalyzes the synthesis of GMP from XMP
GD630_RS12965	COG5002	protein histidine kinase activity
GD630_RS12970	COG2205	protein histidine kinase activity
GD630_RS12980	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GD630_RS12985	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GD630_RS12990	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GD630_RS13005	COG3387	PFAM Glycoside hydrolase 15-related
GD630_RS13140	COG0740	serine-type endopeptidase activity
GD630_RS13160	COG4383	Mu-like prophage protein gp29
GD630_RS13340	COG0667	Aldo Keto reductase
GD630_RS13345	COG1696	Membrane protein involved in D-alanine export
GD630_RS13370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS13380	COG1309	transcriptional regulator
GD630_RS13390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GD630_RS13405	COG0203	ribosomal protein L17
GD630_RS13410	COG0202	RNA polymerase activity
GD630_RS13415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GD630_RS13420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GD630_RS13425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GD630_RS13430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GD630_RS13435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GD630_RS13450	COG0200	Binds to the 23S rRNA
GD630_RS13455	COG1841	ribosomal large subunit assembly
GD630_RS13460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GD630_RS13465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GD630_RS13470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GD630_RS13475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GD630_RS13480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GD630_RS13485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GD630_RS13490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GD630_RS13495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GD630_RS13500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GD630_RS13505	COG0255	Belongs to the universal ribosomal protein uL29 family
GD630_RS13510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GD630_RS13515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GD630_RS13520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GD630_RS13525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GD630_RS13530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GD630_RS13535	COG0089	rRNA binding
GD630_RS13540	COG0088	Forms part of the polypeptide exit tunnel
GD630_RS13545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GD630_RS13550	COG0051	transcription antitermination factor activity, RNA binding
GD630_RS13555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GD630_RS13560	COG0049	tRNA binding
GD630_RS13565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GD630_RS13575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GD630_RS13580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GD630_RS13610	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GD630_RS13615	COG0793	Belongs to the peptidase S41A family
GD630_RS13620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GD630_RS13670	COG0702	epimerase
GD630_RS13675	COG4771	TonB-dependent receptor
GD630_RS13680	COG1609	Transcriptional regulator
GD630_RS13710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GD630_RS13715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GD630_RS13725	COG1629	transport
GD630_RS13730	COG0702	epimerase
GD630_RS13750	COG4948	Mandelate Racemase Muconate Lactonizing
GD630_RS13755	COG0673	inositol 2-dehydrogenase activity
GD630_RS13770	COG3634	alkyl hydroperoxide reductase activity
GD630_RS13790	COG3250	beta-galactosidase activity
GD630_RS13795	COG0702	epimerase
GD630_RS13810	COG4771	TonB-dependent receptor
GD630_RS13820	COG2755	lipolytic protein G-D-S-L family
GD630_RS13820	COG0657	acetylesterase activity
GD630_RS13830	COG2731	YhcH YjgK YiaL family protein
GD630_RS13835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GD630_RS13840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GD630_RS13885	COG0018	arginyl-trna synthetase
GD630_RS13890	COG3292	Two component regulator propeller
GD630_RS13890	COG0745	RESPONSE REGULATOR receiver
GD630_RS13890	COG2205	protein histidine kinase activity
GD630_RS13910	COG4771	TonB-dependent receptor
GD630_RS13930	COG4771	TonB-dependent receptor
GD630_RS13935	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GD630_RS13945	COG3401	FG-GAP repeat protein
GD630_RS13955	COG2755	lipolytic protein G-D-S-L family
GD630_RS13980	COG3401	FG-GAP repeat protein
GD630_RS13985	COG2755	lipolytic protein G-D-S-L family
GD630_RS13995	COG3250	beta-galactosidase activity
GD630_RS14010	COG0705	Rhomboid family
GD630_RS14025	COG0339	signal peptide processing
GD630_RS14030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GD630_RS14040	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GD630_RS14040	COG0674	pyruvate-flavodoxin oxidoreductase activity
GD630_RS14045	COG1013	pyruvate-flavodoxin oxidoreductase activity
GD630_RS14060	COG3250	beta-galactosidase activity
GD630_RS14065	COG3458	cephalosporin-C deacetylase activity
GD630_RS14070	COG3345	alpha-galactosidase
GD630_RS14075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GD630_RS14080	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS14110	COG1629	transport
GD630_RS14125	COG4591	ABC-type transport system involved in lipoprotein release permease component
GD630_RS14130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GD630_RS14150	COG4974	Belongs to the 'phage' integrase family
GD630_RS14165	COG0606	chelatase, subunit chli
GD630_RS14185	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS14195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GD630_RS14200	COG4771	TonB-dependent receptor
GD630_RS14205	COG3119	arylsulfatase activity
GD630_RS14210	COG3940	Belongs to the glycosyl hydrolase 43 family
GD630_RS14215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GD630_RS14225	COG4771	TonB-dependent receptor
GD630_RS14235	COG4771	TonB-dependent receptor
GD630_RS14270	COG3537	Alpha-1,2-mannosidase
GD630_RS14285	COG0745	RESPONSE REGULATOR receiver
GD630_RS14285	COG2205	protein histidine kinase activity
GD630_RS14285	COG3292	Two component regulator propeller
GD630_RS14295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GD630_RS14295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GD630_RS14300	COG2244	polysaccharide biosynthetic process
GD630_RS14310	COG1216	Glycosyl transferase, family 2
GD630_RS14335	COG0438	transferase activity, transferring glycosyl groups
GD630_RS14360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GD630_RS14365	COG0545	Peptidyl-prolyl cis-trans isomerase
GD630_RS14370	COG0545	Peptidyl-prolyl cis-trans isomerase
GD630_RS14445	COG0210	DNA helicase
GD630_RS14505	COG3328	transposase activity
GD630_RS14520	COG0582	viral genome integration into host DNA
GD630_RS14580	COG0561	phosphatase activity
GD630_RS14585	COG1595	DNA-templated transcription, initiation
GD630_RS14630	COG4771	TonB-dependent receptor
GD630_RS14635	COG0702	epimerase
GD630_RS14645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GD630_RS14650	COG3250	beta-galactosidase activity
GD630_RS14655	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GD630_RS14665	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GD630_RS14670	COG2211	Major facilitator Superfamily
GD630_RS14675	COG3250	beta-galactosidase activity
GD630_RS14700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GD630_RS14705	COG0793	Belongs to the peptidase S41A family
GD630_RS14705	COG3409	Peptidoglycan-binding domain 1 protein
GD630_RS14725	COG3328	transposase activity
GD630_RS14750	COG0702	epimerase
GD630_RS14755	COG4771	TonB-dependent receptor
GD630_RS14765	COG2205	protein histidine kinase activity
GD630_RS14765	COG0745	RESPONSE REGULATOR receiver
GD630_RS14765	COG3292	Two component regulator propeller
GD630_RS14765	COG0745	RESPONSE REGULATOR receiver
GD630_RS14765	COG2205	protein histidine kinase activity
GD630_RS14765	COG3292	Two component regulator propeller
GD630_RS14785	COG1053	succinate dehydrogenase
GD630_RS14790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GD630_RS14810	COG0673	inositol 2-dehydrogenase activity
GD630_RS14820	COG0673	inositol 2-dehydrogenase activity
GD630_RS14825	COG4948	Mandelate Racemase Muconate Lactonizing
GD630_RS14835	COG4948	Mandelate Racemase Muconate Lactonizing
GD630_RS14845	COG3408	Glycogen debranching enzyme
GD630_RS14845	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GD630_RS14860	COG3119	arylsulfatase activity
GD630_RS14865	COG2205	protein histidine kinase activity
GD630_RS14865	COG0745	RESPONSE REGULATOR receiver
GD630_RS14865	COG3292	Two component regulator propeller
GD630_RS14870	COG3119	arylsulfatase activity
GD630_RS14875	COG3119	arylsulfatase activity
GD630_RS14885	COG4771	TonB-dependent receptor
GD630_RS14910	COG3250	beta-galactosidase activity
GD630_RS14935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GD630_RS14935	COG0758	DNA mediated transformation
GD630_RS14945	COG0826	peptidase U32
GD630_RS14950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GD630_RS15030	COG0557	exoribonuclease II activity
GD630_RS15040	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS15045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GD630_RS15050	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS15080	COG0702	epimerase
GD630_RS15085	COG4771	TonB-dependent receptor
GD630_RS15110	COG4804	nuclease activity
GD630_RS15125	COG0551	DNA topoisomerase type I activity
GD630_RS15125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GD630_RS15145	COG4974	Belongs to the 'phage' integrase family
GD630_RS15385	COG3344	reverse transcriptase
GD630_RS15510	COG4974	Belongs to the 'phage' integrase family
GD630_RS15550	COG2271	Major facilitator Superfamily
GD630_RS15555	COG1917	Cupin 2, conserved barrel domain protein
GD630_RS15575	COG0702	epimerase
GD630_RS15580	COG1629	transport
GD630_RS15585	COG2186	Transcriptional regulator
GD630_RS15615	COG0702	epimerase
GD630_RS15620	COG4206	TonB-dependent receptor
GD630_RS15620	COG1629	transport
GD630_RS15635	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GD630_RS15640	COG2205	protein histidine kinase activity
GD630_RS15640	COG0745	RESPONSE REGULATOR receiver
GD630_RS15640	COG3292	Two component regulator propeller
GD630_RS15640	COG2205	protein histidine kinase activity
GD630_RS15640	COG0745	RESPONSE REGULATOR receiver
GD630_RS15640	COG3292	Two component regulator propeller
GD630_RS15670	COG0702	epimerase
GD630_RS15675	COG4771	TonB-dependent receptor
GD630_RS15715	COG0561	phosphatase activity
GD630_RS15720	COG1629	transport
GD630_RS15725	COG2205	protein histidine kinase activity
GD630_RS15725	COG0745	RESPONSE REGULATOR receiver
GD630_RS15725	COG3292	Two component regulator propeller
GD630_RS15760	COG3250	beta-galactosidase activity
GD630_RS15785	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS15790	COG3250	beta-galactosidase activity
GD630_RS15800	COG2755	lipolytic protein G-D-S-L family
GD630_RS15800	COG0657	acetylesterase activity
GD630_RS15805	COG2814	Major facilitator Superfamily
GD630_RS15810	COG0012	GTP binding
GD630_RS15815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GD630_RS15820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GD630_RS15830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GD630_RS15835	COG0697	spore germination
GD630_RS15850	COG3537	Alpha-1,2-mannosidase
GD630_RS15870	COG0702	epimerase
GD630_RS15875	COG4771	TonB-dependent receptor
GD630_RS15885	COG3537	Alpha-1,2-mannosidase
GD630_RS15895	COG0495	leucyl-tRNA aminoacylation
GD630_RS15900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD630_RS15905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GD630_RS15915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GD630_RS15945	COG4771	TonB-dependent receptor
GD630_RS15975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GD630_RS15975	COG0731	radical SAM domain protein
GD630_RS15990	COG0659	secondary active sulfate transmembrane transporter activity
GD630_RS15995	COG1592	Rubrerythrin
GD630_RS16020	COG1629	transport
GD630_RS16035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GD630_RS16055	COG0427	acetyl-CoA hydrolase
GD630_RS16065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GD630_RS16070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GD630_RS16075	COG2177	Part of the ABC transporter FtsEX involved in
GD630_RS16085	COG1968	undecaprenyl-diphosphatase activity
GD630_RS16090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GD630_RS16095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GD630_RS16100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GD630_RS16110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GD630_RS16130	COG0594	ribonuclease P activity
GD630_RS16135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GD630_RS16145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GD630_RS16155	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GD630_RS16160	COG1028	Short-chain dehydrogenase reductase Sdr
GD630_RS16195	COG0726	polysaccharide deacetylase
GD630_RS16215	COG4771	TonB-dependent receptor
GD630_RS16250	COG1121	(ABC) transporter
GD630_RS16260	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GD630_RS16260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GD630_RS16265	COG1238	metal cluster binding
GD630_RS16280	COG0823	Involved in the tonB-independent uptake of proteins
GD630_RS16280	COG1506	peptidase
GD630_RS16290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GD630_RS16290	COG0116	Belongs to the methyltransferase superfamily
GD630_RS16295	COG1045	serine acetyltransferase
GD630_RS16305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GD630_RS16305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GD630_RS16325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GD630_RS16330	COG1694	Mazg nucleotide pyrophosphohydrolase
GD630_RS16335	COG1490	D-aminoacyl-tRNA deacylase activity
GD630_RS16340	COG0322	excinuclease ABC activity
GD630_RS16345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GD630_RS16350	COG0445	tRNA wobble uridine modification
GD630_RS16365	COG4771	TonB-dependent receptor
GD630_RS16415	COG4771	TonB-dependent receptor
GD630_RS16445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GD630_RS16450	COG2715	membrane protein required for spore maturation
GD630_RS16455	COG2255	four-way junction helicase activity
GD630_RS16470	COG3591	Belongs to the peptidase S1B family
GD630_RS16490	COG0517	IMP dehydrogenase activity
GD630_RS16490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GD630_RS16500	COG0612	Peptidase, M16
GD630_RS16520	COG4771	TonB-dependent receptor
GD630_RS16525	COG0702	epimerase
GD630_RS16545	COG1472	Belongs to the glycosyl hydrolase 3 family
GD630_RS16570	COG0681	Belongs to the peptidase S26 family
GD630_RS16580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GD630_RS16630	COG5492	domain, Protein
GD630_RS16640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GD630_RS16665	COG4771	TonB-dependent receptor
GD630_RS16670	COG3119	arylsulfatase activity
GD630_RS16675	COG2205	protein histidine kinase activity
GD630_RS16675	COG0745	RESPONSE REGULATOR receiver
GD630_RS16675	COG3292	Two component regulator propeller
GD630_RS16675	COG3292	Two component regulator propeller
GD630_RS16675	COG0745	RESPONSE REGULATOR receiver
GD630_RS16675	COG2205	protein histidine kinase activity
GD630_RS16685	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GD630_RS16690	COG1538	Outer membrane efflux protein
GD630_RS16700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS16705	COG3250	beta-galactosidase activity
GD630_RS16730	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS16735	COG3119	arylsulfatase activity
GD630_RS16740	COG5492	domain, Protein
GD630_RS16745	COG0215	cysteine-tRNA ligase activity
GD630_RS16750	COG0561	phosphatase activity
GD630_RS16755	COG2361	Protein of unknown function DUF86
GD630_RS16765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GD630_RS16770	COG0482	sulfurtransferase activity
GD630_RS16780	COG0205	6-phosphofructokinase activity
GD630_RS16785	COG0571	ribonuclease III activity
GD630_RS16790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GD630_RS16795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GD630_RS16800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GD630_RS16805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GD630_RS16820	COG3475	LICD family
GD630_RS16825	COG0562	UDP-galactopyranose mutase
GD630_RS16845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GD630_RS16880	COG1216	Glycosyl transferase, family 2
GD630_RS16885	COG1132	(ABC) transporter
GD630_RS16890	COG1215	transferase activity, transferring glycosyl groups
GD630_RS16895	COG1368	sulfuric ester hydrolase activity
GD630_RS16935	COG0584	glycerophosphoryl diester phosphodiesterase
GD630_RS16940	COG1629	transport
GD630_RS16940	COG4206	TonB-dependent receptor
GD630_RS16955	COG0584	glycerophosphoryl diester phosphodiesterase
GD630_RS16990	COG0463	Glycosyl transferase, family 2
GD630_RS17000	COG1368	sulfuric ester hydrolase activity
GD630_RS17010	COG0328	RNA-DNA hybrid ribonuclease activity
GD630_RS17010	COG3341	Caulimovirus viroplasmin
GD630_RS17020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GD630_RS17025	COG1166	arginine decarboxylase activity
GD630_RS17030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GD630_RS17035	COG1595	DNA-templated transcription, initiation
GD630_RS17055	COG0779	Required for maturation of 30S ribosomal subunits
GD630_RS17060	COG0195	Participates in both transcription termination and antitermination
GD630_RS17065	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GD630_RS17075	COG0719	Fe-S assembly protein
GD630_RS17080	COG0396	ATPase activity
GD630_RS17085	COG0719	Fe-S assembly protein
GD630_RS17090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GD630_RS17100	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GD630_RS17105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GD630_RS17170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GD630_RS17180	COG0187	DNA topoisomerase II activity
GD630_RS17185	COG0268	Binds directly to 16S ribosomal RNA
GD630_RS17195	COG1381	Involved in DNA repair and RecF pathway recombination
GD630_RS17205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GD630_RS17220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GD630_RS17225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GD630_RS17230	COG0772	Belongs to the SEDS family
GD630_RS17235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GD630_RS17240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GD630_RS17245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GD630_RS17260	COG0275	rRNA processing
GD630_RS17265	COG2001	Belongs to the MraZ family
GD630_RS17270	COG1595	DNA-templated transcription, initiation
GD630_RS17285	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GD630_RS17290	COG0756	dUTP diphosphatase activity
GD630_RS17305	COG4942	peptidase
GD630_RS17310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GD630_RS17315	COG1022	Amp-dependent synthetase and ligase
GD630_RS17330	COG2954	triphosphatase activity
GD630_RS17410	COG0358	DNA primase activity
GD630_RS17445	COG4771	TonB-dependent receptor
GD630_RS17450	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GD630_RS17470	COG1082	Xylose isomerase domain protein TIM barrel
GD630_RS17475	COG1082	Xylose isomerase domain protein TIM barrel
GD630_RS17485	COG4804	nuclease activity
GD630_RS17490	COG4974	Belongs to the 'phage' integrase family
GD630_RS17505	COG2252	PERMEase
GD630_RS17515	COG2096	Adenosyltransferase
GD630_RS17530	COG0252	asparaginase activity
GD630_RS17535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GD630_RS17540	COG1027	Aspartate ammonia-lyase
GD630_RS17545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GD630_RS17560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GD630_RS17565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GD630_RS17575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GD630_RS17585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GD630_RS17590	COG0006	proline dipeptidase activity
GD630_RS17595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GD630_RS17600	COG4974	Belongs to the 'phage' integrase family
GD630_RS17630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GD630_RS17640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GD630_RS17650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GD630_RS17655	COG0081	regulation of translation
GD630_RS17660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GD630_RS17665	COG0222	ribosome binding
GD630_RS17670	COG0085	RNA polymerase activity
GD630_RS17675	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GD630_RS17690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GD630_RS17695	COG1396	sequence-specific DNA binding
GD630_RS17700	COG0318	PFAM AMP-dependent synthetase and ligase
GD630_RS17760	COG0561	phosphatase activity
GD630_RS17765	COG4771	TonB-dependent receptor
GD630_RS17790	COG0673	inositol 2-dehydrogenase activity
GD630_RS17795	COG0673	inositol 2-dehydrogenase activity
GD630_RS17820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GD630_RS17830	COG3392	D12 class N6 adenine-specific DNA methyltransferase
GD630_RS17935	COG0740	serine-type endopeptidase activity
GD630_RS18095	COG0784	Response regulator, receiver
GD630_RS18095	COG2205	protein histidine kinase activity
GD630_RS18130	COG2226	methyltransferase
GD630_RS18150	COG2918	glutathione biosynthetic process
GD630_RS18150	COG0189	ligase activity
GD630_RS18155	COG0534	Mate efflux family protein
GD630_RS18175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GD630_RS18175	COG0551	DNA topoisomerase type I activity
GD630_RS18225	COG2843	Capsule synthesis protein
GD630_RS18235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GD630_RS18240	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GD630_RS18260	COG2172	sigma factor antagonist activity
GD630_RS18265	COG3292	Two component regulator propeller
GD630_RS18265	COG0745	RESPONSE REGULATOR receiver
GD630_RS18265	COG2205	protein histidine kinase activity
GD630_RS18275	COG5434	Belongs to the glycosyl hydrolase 28 family
GD630_RS18285	COG5434	Belongs to the glycosyl hydrolase 28 family
GD630_RS18295	COG4771	TonB-dependent receptor
GD630_RS18300	COG0702	epimerase
GD630_RS18305	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS18315	COG3119	arylsulfatase activity
GD630_RS18325	COG1940	carbohydrate kinase activity
GD630_RS18345	COG3328	transposase activity
GD630_RS18400	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GD630_RS18405	COG0038	chloride channel
GD630_RS18435	COG0443	Heat shock 70 kDa protein
GD630_RS18450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GD630_RS18455	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GD630_RS18460	COG2855	membrane
GD630_RS18465	COG3177	Filamentation induced by cAMP protein fic
GD630_RS18470	COG2314	TM2 domain
GD630_RS18490	COG0583	DNA-binding transcription factor activity
GD630_RS18500	COG0542	response to heat
GD630_RS18515	COG0237	dephospho-CoA kinase activity
GD630_RS18525	COG1862	Preprotein translocase
GD630_RS18530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GD630_RS18540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GD630_RS18545	COG0193	aminoacyl-tRNA hydrolase activity
GD630_RS18550	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GD630_RS18560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GD630_RS18560	COG4651	solute:proton antiporter activity
GD630_RS18565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GD630_RS18570	COG2195	Cleaves the N-terminal amino acid of tripeptides
GD630_RS18575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GD630_RS18580	COG1082	Xylose isomerase domain protein TIM barrel
GD630_RS18585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GD630_RS18590	COG0148	phosphopyruvate hydratase activity
GD630_RS18605	COG0463	Glycosyl transferase, family 2
GD630_RS18620	COG1971	Probably functions as a manganese efflux pump
GD630_RS18625	COG1477	protein flavinylation
GD630_RS18640	COG2195	Cleaves the N-terminal amino acid of tripeptides
GD630_RS18650	COG0668	transmembrane transport
GD630_RS18655	COG3119	arylsulfatase activity
GD630_RS18660	COG3250	beta-galactosidase activity
GD630_RS18665	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GD630_RS18670	COG3119	arylsulfatase activity
GD630_RS18685	COG1629	transport
GD630_RS18685	COG4206	TonB-dependent receptor
GD630_RS18700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GD630_RS18710	COG2205	protein histidine kinase activity
GD630_RS18710	COG0745	RESPONSE REGULATOR receiver
GD630_RS18710	COG2205	protein histidine kinase activity
GD630_RS18710	COG0745	RESPONSE REGULATOR receiver
GD630_RS18710	COG3292	Two component regulator propeller
GD630_RS18710	COG3292	Two component regulator propeller
GD630_RS18715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GD630_RS18720	COG1830	Aldolase
GD630_RS18725	COG0588	phosphoglycerate mutase activity
GD630_RS18730	COG1119	ATPase activity
GD630_RS18735	COG3661	Belongs to the glycosyl hydrolase 67 family
GD630_RS18750	COG2211	Major facilitator Superfamily
GD630_RS18770	COG0561	phosphatase activity
GD630_RS18775	COG1629	transport
GD630_RS18775	COG4206	TonB-dependent receptor
GD630_RS18785	COG3507	Belongs to the glycosyl hydrolase 43 family
GD630_RS18790	COG1523	belongs to the glycosyl hydrolase 13 family
GD630_RS18795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GD630_RS18825	COG4771	TonB-dependent receptor
GD630_RS18835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GD630_RS18840	COG2814	Major facilitator Superfamily
GD630_RS18845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GD630_RS18850	COG0126	phosphoglycerate kinase activity
GD630_RS18860	COG0424	maF-like protein
GD630_RS18880	COG0778	Nitroreductase
GD630_RS18885	COG0288	reversible hydration of carbon dioxide
GD630_RS18895	COG1629	transport
GD630_RS18910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GD630_RS18920	COG0511	ligase activity, forming carbon-carbon bonds
GD630_RS18925	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GD630_RS18930	COG0191	fructose-bisphosphate aldolase activity
GD630_RS18935	COG0254	rRNA binding
GD630_RS18945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS18950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GD630_RS18960	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GD630_RS18975	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GD630_RS18990	COG1280	lysine exporter protein (LysE YggA)
GD630_RS19000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GD630_RS19000	COG0047	phosphoribosylformylglycinamidine synthase activity
GD630_RS19005	COG0745	RESPONSE REGULATOR receiver
GD630_RS19005	COG2205	protein histidine kinase activity
GD630_RS19005	COG3292	Two component regulator propeller
GD630_RS19005	COG0745	RESPONSE REGULATOR receiver
GD630_RS19005	COG2205	protein histidine kinase activity
GD630_RS19005	COG3292	Two component regulator propeller
GD630_RS19020	COG1649	PFAM Uncharacterised BCR, COG1649
GD630_RS19040	COG1966	Carbon starvation protein
GD630_RS19045	COG1649	PFAM Uncharacterised BCR, COG1649
GD630_RS19060	COG5434	Belongs to the glycosyl hydrolase 28 family
GD630_RS19065	COG0702	epimerase
GD630_RS19070	COG4771	TonB-dependent receptor
GD630_RS19080	COG4206	TonB-dependent receptor
GD630_RS19080	COG1629	transport
GD630_RS19090	COG2205	protein histidine kinase activity
GD630_RS19090	COG0745	RESPONSE REGULATOR receiver
GD630_RS19090	COG3292	Two component regulator propeller
GD630_RS19095	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GD630_RS19115	COG2113	Glycine betaine
GD630_RS19120	COG4176	ABC-type proline glycine betaine transport system permease component
GD630_RS19130	COG3695	enzyme binding
GD630_RS19140	COG3292	Two component regulator propeller
GD630_RS19140	COG2205	protein histidine kinase activity
GD630_RS19140	COG0745	RESPONSE REGULATOR receiver
GD630_RS19145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GD630_RS19145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GD630_RS19155	COG1621	beta-fructofuranosidase activity
GD630_RS19170	COG0702	epimerase
GD630_RS19175	COG4771	TonB-dependent receptor
GD630_RS19195	COG1752	Esterase of the alpha-beta hydrolase superfamily
GD630_RS19225	COG4772	TonB-dependent receptor
GD630_RS19250	COG4206	TonB-dependent receptor
GD630_RS19250	COG1629	transport
GD630_RS19260	COG1595	DNA-templated transcription, initiation
GD630_RS19270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GD630_RS19275	COG1960	acyl-CoA dehydrogenase activity
GD630_RS19285	COG0484	heat shock protein binding
GD630_RS19290	COG2194	sulfuric ester hydrolase activity
GD630_RS19305	COG0028	Belongs to the TPP enzyme family
GD630_RS19335	COG0459	protein refolding
GD630_RS19340	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GD630_RS19355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GD630_RS19365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GD630_RS19370	COG0124	histidyl-tRNA synthetase
GD630_RS19385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GD630_RS19465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GD630_RS19475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GD630_RS19480	COG1368	sulfuric ester hydrolase activity
GD630_RS19485	COG0671	phosphoesterase, PA-phosphatase related
GD630_RS19490	COG0473	3-isopropylmalate dehydrogenase activity
GD630_RS19495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GD630_RS19500	COG0066	3-isopropylmalate dehydratase activity
GD630_RS19505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GD630_RS19510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GD630_RS19550	COG4771	TonB-dependent receptor
GD630_RS19580	COG0582	viral genome integration into host DNA
GD630_RS19620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GD630_RS19650	COG1629	transport
GD630_RS19650	COG4206	TonB-dependent receptor
GD630_RS19665	COG0471	metal ion transport
GD630_RS19685	COG0616	signal peptide processing
GD630_RS19690	COG1663	tetraacyldisaccharide 4'-kinase activity
GD630_RS19700	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GD630_RS19715	COG0513	Belongs to the DEAD box helicase family
GD630_RS19720	COG0724	RNA recognition motif
GD630_RS19750	COG1917	Cupin 2, conserved barrel domain protein
GD630_RS19750	COG4977	sequence-specific DNA binding
GD630_RS19770	COG3385	transposase activity
GD630_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
GD630_RS19805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GD630_RS19820	COG3118	belongs to the thioredoxin family
GD630_RS19830	COG0439	Biotin carboxylase
GD630_RS19835	COG5016	pyruvate
GD630_RS19835	COG0511	ligase activity, forming carbon-carbon bonds
GD630_RS19840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GD630_RS19850	COG2873	o-acetylhomoserine
GD630_RS19860	COG1538	Outer membrane efflux protein
GD630_RS19870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS19895	COG4206	TonB-dependent receptor
GD630_RS19895	COG1629	transport
GD630_RS19905	COG1595	DNA-templated transcription, initiation
GD630_RS19915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GD630_RS19930	COG0561	phosphatase activity
GD630_RS19935	COG4771	TonB-dependent receptor
GD630_RS19960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GD630_RS20010	COG1505	serine-type exopeptidase activity
GD630_RS20025	COG3119	arylsulfatase activity
GD630_RS20030	COG0617	tRNA 3'-terminal CCA addition
GD630_RS20045	COG0632	four-way junction helicase activity
GD630_RS20050	COG0673	inositol 2-dehydrogenase activity
GD630_RS20055	COG1272	protein, Hemolysin III
GD630_RS20060	COG1328	CTP reductase activity
GD630_RS20065	COG0602	queuosine metabolic process
GD630_RS20070	COG0750	zinc metalloprotease
GD630_RS20075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GD630_RS20085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GD630_RS20090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GD630_RS20110	COG0194	GDP metabolic process
GD630_RS20115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GD630_RS20120	COG1408	metallophosphoesterase
GD630_RS20125	COG1575	Belongs to the MenA family. Type 1 subfamily
GD630_RS20130	COG1088	dTDP-glucose 4,6-dehydratase activity
GD630_RS20135	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GD630_RS20155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GD630_RS20165	COG4771	TonB-dependent receptor
GD630_RS20180	COG0784	Response regulator, receiver
GD630_RS20180	COG2205	protein histidine kinase activity
GD630_RS20185	COG0488	(ABC) transporter
GD630_RS20195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS20215	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GD630_RS20215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GD630_RS20225	COG1595	DNA-templated transcription, initiation
GD630_RS20240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GD630_RS20250	COG1522	sequence-specific DNA binding
GD630_RS20280	COG0811	peptide transport
GD630_RS20290	COG0084	hydrolase, TatD family'
GD630_RS20310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GD630_RS20315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GD630_RS20320	COG0205	6-phosphofructokinase activity
GD630_RS20330	COG1902	pentaerythritol trinitrate reductase activity
GD630_RS20345	COG0372	Belongs to the citrate synthase family
GD630_RS20360	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GD630_RS20365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GD630_RS20380	COG0028	Belongs to the TPP enzyme family
GD630_RS20385	COG0129	dihydroxy-acid dehydratase activity
GD630_RS20390	COG1047	Peptidyl-prolyl cis-trans
GD630_RS20395	COG3681	Belongs to the UPF0597 family
GD630_RS20415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GD630_RS20420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GD630_RS20475	COG4206	TonB-dependent receptor
GD630_RS20475	COG1629	transport
GD630_RS20485	COG1595	DNA-templated transcription, initiation
GD630_RS20490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GD630_RS20490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GD630_RS20495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GD630_RS20500	COG0569	domain protein
GD630_RS20500	COG2985	domain, Protein
GD630_RS20520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD630_RS20575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GD630_RS20580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GD630_RS20590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GD630_RS20595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GD630_RS20600	COG0166	Belongs to the GPI family
GD630_RS20625	COG2502	aspartate--ammonia ligase
GD630_RS20630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GD630_RS20645	COG3876	Protein conserved in bacteria
GD630_RS20655	COG1733	regulation of RNA biosynthetic process
GD630_RS20705	COG0358	DNA primase activity
GD630_RS20735	COG0860	N-Acetylmuramoyl-L-alanine amidase
GD630_RS20745	COG1192	Involved in chromosome partitioning
GD630_RS20965	COG0629	single-stranded DNA binding
GD630_RS21055	COG3385	transposase activity
GD630_RS21060	COG4474	Belongs to the UPF0398 family
GD630_RS21125	COG0776	regulation of translation
GD630_RS21135	COG2337	Toxic component of a toxin-antitoxin (TA) module
GD630_RS21170	COG2003	Belongs to the UPF0758 family
GD630_RS21205	COG0656	L-ascorbic acid biosynthetic process
GD630_RS21215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GD630_RS21230	COG0784	Response regulator, receiver
GD630_RS21230	COG2205	protein histidine kinase activity
GD630_RS21235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs