locus-tag	class	description
K6V31_RS00010	COG0629	single-stranded DNA binding
K6V31_RS00025	COG3033	Beta-eliminating lyase
K6V31_RS00030	COG5002	protein histidine kinase activity
K6V31_RS00035	COG0745	RESPONSE REGULATOR receiver
K6V31_RS00045	COG1629	transport
K6V31_RS00045	COG4206	TonB-dependent receptor
K6V31_RS00060	COG0488	(ABC) transporter
K6V31_RS00075	COG3118	belongs to the thioredoxin family
K6V31_RS00080	COG3591	Belongs to the peptidase S1B family
K6V31_RS00085	COG3591	Belongs to the peptidase S1B family
K6V31_RS00090	COG0641	radical SAM
K6V31_RS00125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6V31_RS00130	COG0463	Glycosyl transferase, family 2
K6V31_RS00135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6V31_RS00170	COG1032	radical SAM domain protein
K6V31_RS00190	COG0363	glucosamine-6-phosphate deaminase activity
K6V31_RS00205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V31_RS00240	COG3757	hydrolase, family 25
K6V31_RS00245	COG2264	protein methyltransferase activity
K6V31_RS00260	COG1773	rubredoxin
K6V31_RS00260	COG1592	Rubrerythrin
K6V31_RS00270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6V31_RS00270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V31_RS00275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6V31_RS00285	COG4585	Histidine kinase
K6V31_RS00295	COG2197	response regulator
K6V31_RS00345	COG0698	ribose 5-phosphate isomerase
K6V31_RS00355	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6V31_RS00360	COG0738	Major facilitator superfamily
K6V31_RS00370	COG1482	cell wall glycoprotein biosynthetic process
K6V31_RS00385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6V31_RS00395	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
K6V31_RS00395	COG0028	Belongs to the TPP enzyme family
K6V31_RS00400	COG1454	alcohol dehydrogenase
K6V31_RS00445	COG3754	Rhamnan synthesis protein F
K6V31_RS00460	COG1216	Glycosyl transferase, family 2
K6V31_RS00490	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6V31_RS00495	COG0471	metal ion transport
K6V31_RS00495	COG3273	potassium ion transport
K6V31_RS00500	COG0529	Catalyzes the synthesis of activated sulfate
K6V31_RS00505	COG0175	sulfate reduction
K6V31_RS00510	COG2895	sulfate adenylyltransferase (ATP) activity
K6V31_RS00525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6V31_RS00530	COG0242	peptide deformylase activity
K6V31_RS00540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6V31_RS00545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K6V31_RS00550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6V31_RS00555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K6V31_RS00570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V31_RS00585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6V31_RS00630	COG0484	heat shock protein binding
K6V31_RS00635	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6V31_RS00640	COG0488	(ABC) transporter
K6V31_RS00655	COG2183	response to ionizing radiation
K6V31_RS00660	COG0737	Belongs to the 5'-nucleotidase family
K6V31_RS00670	COG4771	TonB-dependent receptor
K6V31_RS00675	COG1917	Cupin 2, conserved barrel domain protein
K6V31_RS00675	COG4977	sequence-specific DNA binding
K6V31_RS00775	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V31_RS00810	COG0534	Mate efflux family protein
K6V31_RS00860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6V31_RS00895	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K6V31_RS00905	COG3119	arylsulfatase activity
K6V31_RS00910	COG0318	PFAM AMP-dependent synthetase and ligase
K6V31_RS00915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V31_RS00925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6V31_RS00930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6V31_RS00935	COG0363	glucosamine-6-phosphate deaminase activity
K6V31_RS00945	COG0259	pyridoxamine-phosphate oxidase activity
K6V31_RS00955	COG3279	Response regulator of the LytR AlgR family
K6V31_RS00965	COG1136	(ABC) transporter
K6V31_RS00965	COG0577	efflux transmembrane transporter activity
K6V31_RS00970	COG1136	(ABC) transporter
K6V31_RS00990	COG1271	oxidase subunit
K6V31_RS01010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6V31_RS01015	COG1177	transmembrane transport
K6V31_RS01020	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6V31_RS01030	COG4221	oxidoreductase activity
K6V31_RS01035	COG0534	Mate efflux family protein
K6V31_RS01115	COG5002	protein histidine kinase activity
K6V31_RS01145	COG3275	phosphorelay sensor kinase activity
K6V31_RS01180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6V31_RS01185	COG1882	Formate acetyltransferase
K6V31_RS01195	COG4974	Belongs to the 'phage' integrase family
K6V31_RS01230	COG3292	Two component regulator propeller
K6V31_RS01230	COG2205	protein histidine kinase activity
K6V31_RS01230	COG0745	RESPONSE REGULATOR receiver
K6V31_RS01230	COG3292	Two component regulator propeller
K6V31_RS01230	COG0745	RESPONSE REGULATOR receiver
K6V31_RS01230	COG2205	protein histidine kinase activity
K6V31_RS01235	COG4771	TonB-dependent receptor
K6V31_RS01240	COG0702	epimerase
K6V31_RS01270	COG3250	beta-galactosidase activity
K6V31_RS01335	COG2113	Glycine betaine
K6V31_RS01340	COG4176	ABC-type proline glycine betaine transport system permease component
K6V31_RS01375	COG1733	regulation of RNA biosynthetic process
K6V31_RS01380	COG2814	Major facilitator Superfamily
K6V31_RS01390	COG0697	spore germination
K6V31_RS01395	COG1917	Cupin 2, conserved barrel domain protein
K6V31_RS01395	COG4977	sequence-specific DNA binding
K6V31_RS01485	COG1309	transcriptional regulator
K6V31_RS01495	COG0488	(ABC) transporter
K6V31_RS01525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V31_RS01530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6V31_RS01565	COG2205	protein histidine kinase activity
K6V31_RS01565	COG0784	Response regulator, receiver
K6V31_RS01585	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V31_RS01590	COG1805	sodium ion transport
K6V31_RS01595	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V31_RS01605	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6V31_RS01620	COG0513	Belongs to the DEAD box helicase family
K6V31_RS01625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6V31_RS01640	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V31_RS01645	COG0534	Mate efflux family protein
K6V31_RS01655	COG1739	Uncharacterized protein family UPF0029
K6V31_RS01675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V31_RS01675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6V31_RS01680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6V31_RS01685	COG0357	Ribosomal RNA small subunit methyltransferase G
K6V31_RS01705	COG1929	Belongs to the glycerate kinase type-1 family
K6V31_RS01725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V31_RS01745	COG1216	Glycosyl transferase, family 2
K6V31_RS01745	COG1442	glycosyl transferase family 8
K6V31_RS01755	COG1216	Glycosyl transferase, family 2
K6V31_RS01755	COG1442	glycosyl transferase family 8
K6V31_RS01820	COG0217	transcriptional regulatory protein
K6V31_RS01835	COG0708	Exodeoxyribonuclease III
K6V31_RS01850	COG0481	GTPase activity
K6V31_RS01855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6V31_RS01860	COG2233	PERMEase
K6V31_RS01865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V31_RS01870	COG1322	Protein conserved in bacteria
K6V31_RS01875	COG0024	Methionine aminopeptidase
K6V31_RS01890	COG2814	Major facilitator Superfamily
K6V31_RS01905	COG0564	pseudouridine synthase activity
K6V31_RS01910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6V31_RS01915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6V31_RS01915	COG0574	Belongs to the PEP-utilizing enzyme family
K6V31_RS01920	COG1401	restriction endodeoxyribonuclease activity
K6V31_RS01985	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6V31_RS02000	COG1678	Uncharacterized ACR, COG1678
K6V31_RS02045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6V31_RS02055	COG0738	Major facilitator superfamily
K6V31_RS02080	COG3969	phosphoadenosine phosphosulfate
K6V31_RS02085	COG1475	DNA binding
K6V31_RS02090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V31_RS02105	COG1074	ATP-dependent DNA helicase activity
K6V31_RS02115	COG0556	nucleotide-excision repair
K6V31_RS02120	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K6V31_RS02150	COG1388	LysM domain
K6V31_RS02150	COG3942	CHAP domain
K6V31_RS02155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6V31_RS02160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6V31_RS02175	COG1695	Transcriptional regulator
K6V31_RS02180	COG1983	PspC domain protein
K6V31_RS02185	COG1506	peptidase
K6V31_RS02185	COG0823	Involved in the tonB-independent uptake of proteins
K6V31_RS02190	COG0534	Mate efflux family protein
K6V31_RS02200	COG0504	CTP synthase activity
K6V31_RS02220	COG4656	Part of a membrane complex involved in electron transport
K6V31_RS02225	COG4658	electron transport chain
K6V31_RS02230	COG4659	FMN binding
K6V31_RS02235	COG4660	Part of a membrane complex involved in electron transport
K6V31_RS02240	COG4657	Part of a membrane complex involved in electron transport
K6V31_RS02245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6V31_RS02265	COG0356	it plays a direct role in the translocation of protons across the membrane
K6V31_RS02270	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V31_RS02275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6V31_RS02280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V31_RS02285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6V31_RS02290	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6V31_RS02295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V31_RS02320	COG0784	Response regulator, receiver
K6V31_RS02320	COG2205	protein histidine kinase activity
K6V31_RS02325	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6V31_RS02330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6V31_RS02345	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K6V31_RS02350	COG0540	Belongs to the ATCase OTCase family
K6V31_RS02355	COG4974	Belongs to the 'phage' integrase family
K6V31_RS02425	COG2244	polysaccharide biosynthetic process
K6V31_RS02485	COG0489	protein tyrosine kinase activity
K6V31_RS02495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6V31_RS02505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K6V31_RS02520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6V31_RS02525	COG2205	protein histidine kinase activity
K6V31_RS02540	COG5434	Belongs to the glycosyl hydrolase 28 family
K6V31_RS02570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6V31_RS02575	COG2731	YhcH YjgK YiaL family protein
K6V31_RS02600	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K6V31_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
K6V31_RS02630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6V31_RS02635	COG0656	L-ascorbic acid biosynthetic process
K6V31_RS02655	COG1595	DNA-templated transcription, initiation
K6V31_RS02695	COG4932	domain protein
K6V31_RS02695	COG5492	domain, Protein
K6V31_RS02705	COG0351	phosphomethylpyrimidine kinase
K6V31_RS02715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6V31_RS02725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6V31_RS02730	COG2022	thiamine diphosphate biosynthetic process
K6V31_RS02735	COG0352	thiamine-phosphate diphosphorylase activity
K6V31_RS02740	COG2104	thiamine diphosphate biosynthetic process
K6V31_RS02750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6V31_RS02780	COG2115	Belongs to the xylose isomerase family
K6V31_RS02785	COG2814	Major facilitator Superfamily
K6V31_RS02785	COG0477	Major facilitator Superfamily
K6V31_RS02795	COG3153	acetyltransferase
K6V31_RS02795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6V31_RS02800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6V31_RS02810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K6V31_RS02825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6V31_RS02850	COG2194	sulfuric ester hydrolase activity
K6V31_RS02865	COG0705	Rhomboid family
K6V31_RS02930	COG1733	regulation of RNA biosynthetic process
K6V31_RS02935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V31_RS03040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V31_RS03055	COG1904	glucuronate isomerase
K6V31_RS03060	COG1609	Transcriptional regulator
K6V31_RS03065	COG0246	Mannitol dehydrogenase
K6V31_RS03110	COG0513	Belongs to the DEAD box helicase family
K6V31_RS03115	COG0560	Phosphoserine phosphatase
K6V31_RS03115	COG3830	Belongs to the UPF0237 family
K6V31_RS03130	COG0343	queuine tRNA-ribosyltransferase activity
K6V31_RS03135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6V31_RS03140	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6V31_RS03165	COG0501	Belongs to the peptidase M48B family
K6V31_RS03170	COG0156	8-amino-7-oxononanoate synthase activity
K6V31_RS03175	COG1597	lipid kinase activity
K6V31_RS03180	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6V31_RS03210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6V31_RS03225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6V31_RS03235	COG1538	Outer membrane efflux protein
K6V31_RS03260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V31_RS03275	COG0543	2 iron, 2 sulfur cluster binding
K6V31_RS03280	COG0167	dihydroorotate dehydrogenase activity
K6V31_RS03285	COG0336	Belongs to the RNA methyltransferase TrmD family
K6V31_RS03290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6V31_RS03295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6V31_RS03320	COG0542	response to heat
K6V31_RS03365	COG2304	oxidoreductase activity
K6V31_RS03380	COG0714	Associated with various cellular activities
K6V31_RS03385	COG0776	regulation of translation
K6V31_RS03395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V31_RS03400	COG0552	protein localization to endoplasmic reticulum
K6V31_RS03410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6V31_RS03415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6V31_RS03420	COG1058	Belongs to the CinA family
K6V31_RS03420	COG1546	Belongs to the CinA family
K6V31_RS03425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6V31_RS03470	COG0305	Participates in initiation and elongation during chromosome replication
K6V31_RS03475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6V31_RS03485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6V31_RS03495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V31_RS03510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6V31_RS03515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V31_RS03520	COG0534	Mate efflux family protein
K6V31_RS03525	COG0577	efflux transmembrane transporter activity
K6V31_RS03525	COG1136	(ABC) transporter
K6V31_RS03550	COG4191	Histidine kinase
K6V31_RS03555	COG3263	regulation of cellular component size
K6V31_RS03560	COG1022	Amp-dependent synthetase and ligase
K6V31_RS03595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6V31_RS03605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6V31_RS03605	COG2755	lipolytic protein G-D-S-L family
K6V31_RS03615	COG0842	Transport permease protein
K6V31_RS03620	COG1131	(ABC) transporter
K6V31_RS03635	COG1917	Cupin 2, conserved barrel domain protein
K6V31_RS03635	COG2207	Transcriptional regulator
K6V31_RS03665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V31_RS03670	COG0505	Belongs to the CarA family
K6V31_RS03675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6V31_RS03690	COG3610	response to peptide
K6V31_RS03700	COG0058	SHG alpha-glucan phosphorylase activity
K6V31_RS03710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6V31_RS03730	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K6V31_RS03785	COG0133	tryptophan synthase activity
K6V31_RS03790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6V31_RS03795	COG0512	Glutamine amidotransferase of anthranilate synthase
K6V31_RS03795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6V31_RS03800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6V31_RS03805	COG0134	indole-3-glycerol-phosphate synthase activity
K6V31_RS03810	COG0135	phosphoribosylanthranilate isomerase activity
K6V31_RS03815	COG0159	tryptophan synthase activity
K6V31_RS03820	COG0252	asparaginase activity
K6V31_RS03875	COG1442	glycosyl transferase family 8
K6V31_RS03875	COG1216	Glycosyl transferase, family 2
K6V31_RS03895	COG1216	Glycosyl transferase, family 2
K6V31_RS03900	COG1216	Glycosyl transferase, family 2
K6V31_RS03920	COG1609	Transcriptional regulator
K6V31_RS03925	COG2721	sulfolactate sulfo-lyase activity
K6V31_RS03940	COG0228	four-way junction DNA binding
K6V31_RS03945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6V31_RS03965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6V31_RS03965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6V31_RS03980	COG2226	methyltransferase
K6V31_RS03990	COG1215	transferase activity, transferring glycosyl groups
K6V31_RS03995	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6V31_RS04000	COG0436	Aminotransferase
K6V31_RS04020	COG0577	efflux transmembrane transporter activity
K6V31_RS04020	COG1136	(ABC) transporter
K6V31_RS04030	COG1136	(ABC) transporter
K6V31_RS04030	COG0577	efflux transmembrane transporter activity
K6V31_RS04045	COG0577	efflux transmembrane transporter activity
K6V31_RS04050	COG1136	(ABC) transporter
K6V31_RS04055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V31_RS04065	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6V31_RS04070	COG0295	cytidine deaminase activity
K6V31_RS04075	COG0488	(ABC) transporter
K6V31_RS04110	COG4771	TonB-dependent receptor
K6V31_RS04125	COG0442	prolyl-tRNA aminoacylation
K6V31_RS04140	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6V31_RS04145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K6V31_RS04155	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K6V31_RS04165	COG1492	cobalamin metabolic process
K6V31_RS04175	COG4948	Mandelate Racemase Muconate Lactonizing
K6V31_RS04180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6V31_RS04185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6V31_RS04190	COG1169	isochorismate synthase
K6V31_RS04215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V31_RS04225	COG2096	Adenosyltransferase
K6V31_RS04230	COG1797	cobyrinic acid a,c-diamide synthase activity
K6V31_RS04235	COG1660	Displays ATPase and GTPase activities
K6V31_RS04240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K6V31_RS04245	COG4771	TonB-dependent receptor
K6V31_RS04250	COG4822	anaerobic cobalamin biosynthetic process
K6V31_RS04255	COG4206	TonB-dependent receptor
K6V31_RS04280	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K6V31_RS04290	COG1120	ATPase activity
K6V31_RS04305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V31_RS04310	COG3059	membrane
K6V31_RS04335	COG2755	lipolytic protein G-D-S-L family
K6V31_RS04335	COG0657	acetylesterase activity
K6V31_RS04340	COG3250	beta-galactosidase activity
K6V31_RS04360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V31_RS04370	COG0739	heme binding
K6V31_RS04375	COG0686	Belongs to the AlaDH PNT family
K6V31_RS04385	COG0076	glutamate decarboxylase activity
K6V31_RS04390	COG2066	Belongs to the glutaminase family
K6V31_RS04400	COG0531	amino acid
K6V31_RS04425	COG1595	DNA-templated transcription, initiation
K6V31_RS04440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6V31_RS04450	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6V31_RS04465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6V31_RS04470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V31_RS04480	COG4948	Mandelate Racemase Muconate Lactonizing
K6V31_RS04500	COG0778	Nitroreductase
K6V31_RS04510	COG0704	Plays a role in the regulation of phosphate uptake
K6V31_RS04515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V31_RS04525	COG0586	Pfam SNARE associated Golgi protein
K6V31_RS04530	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6V31_RS04550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6V31_RS04555	COG0167	dihydroorotate dehydrogenase activity
K6V31_RS04560	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6V31_RS04580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6V31_RS04585	COG0497	DNA recombination
K6V31_RS04600	COG0592	DNA-directed DNA polymerase activity
K6V31_RS04615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6V31_RS04615	COG0321	lipoyl(octanoyl) transferase activity
K6V31_RS04620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6V31_RS04630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6V31_RS04635	COG0156	8-amino-7-oxononanoate synthase activity
K6V31_RS04645	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V31_RS04660	COG0305	Participates in initiation and elongation during chromosome replication
K6V31_RS04730	COG5652	VanZ like family
K6V31_RS04735	COG0019	diaminopimelate decarboxylase activity
K6V31_RS04740	COG0527	aspartate kinase activity
K6V31_RS04745	COG2884	Cell division ATP-binding protein ftsE
K6V31_RS04750	COG0140	phosphoribosyl-ATP diphosphatase activity
K6V31_RS04750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6V31_RS04755	COG0107	imidazoleglycerol-phosphate synthase activity
K6V31_RS04760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6V31_RS04765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6V31_RS04770	COG0788	formyltetrahydrofolate deformylase activity
K6V31_RS04800	COG2207	Transcriptional regulator
K6V31_RS04800	COG4753	response regulator
K6V31_RS04830	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6V31_RS04835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6V31_RS04860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6V31_RS04865	COG1741	Belongs to the pirin family
K6V31_RS04940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6V31_RS04945	COG1027	Aspartate ammonia-lyase
K6V31_RS04950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6V31_RS04955	COG0252	asparaginase activity
K6V31_RS04975	COG1918	ferrous iron import across plasma membrane
K6V31_RS04975	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6V31_RS04980	COG0037	tRNA processing
K6V31_RS04995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6V31_RS05000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6V31_RS05025	COG0322	excinuclease ABC activity
K6V31_RS05185	COG4680	protein conserved in bacteria
K6V31_RS05320	COG1061	Type III restriction enzyme res subunit
K6V31_RS05490	COG1193	negative regulation of DNA recombination
K6V31_RS05495	COG1760	l-serine dehydratase
K6V31_RS05510	COG5002	protein histidine kinase activity
K6V31_RS05515	COG0745	RESPONSE REGULATOR receiver
K6V31_RS05545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V31_RS05550	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K6V31_RS05580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6V31_RS05600	COG2814	Major facilitator Superfamily
K6V31_RS05610	COG0561	phosphatase activity
K6V31_RS05620	COG0443	Heat shock 70 kDa protein
K6V31_RS05625	COG0534	Mate efflux family protein
K6V31_RS05645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6V31_RS05650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6V31_RS05680	COG2855	membrane
K6V31_RS05685	COG0583	DNA-binding transcription factor activity
K6V31_RS05695	COG0542	response to heat
K6V31_RS05705	COG0237	dephospho-CoA kinase activity
K6V31_RS05715	COG1862	Preprotein translocase
K6V31_RS05720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6V31_RS05730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6V31_RS05735	COG0193	aminoacyl-tRNA hydrolase activity
K6V31_RS05740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6V31_RS05745	COG0673	inositol 2-dehydrogenase activity
K6V31_RS05755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6V31_RS05755	COG4651	solute:proton antiporter activity
K6V31_RS05765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6V31_RS05775	COG0511	ligase activity, forming carbon-carbon bonds
K6V31_RS05780	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6V31_RS05785	COG0366	Alpha amylase catalytic
K6V31_RS05790	COG0191	fructose-bisphosphate aldolase activity
K6V31_RS05800	COG0254	rRNA binding
K6V31_RS05805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6V31_RS05810	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V31_RS05815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6V31_RS05820	COG1082	Xylose isomerase domain protein TIM barrel
K6V31_RS05825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6V31_RS05835	COG0148	phosphopyruvate hydratase activity
K6V31_RS05850	COG0463	Glycosyl transferase, family 2
K6V31_RS05865	COG1971	Probably functions as a manganese efflux pump
K6V31_RS05870	COG1477	protein flavinylation
K6V31_RS05880	COG0037	tRNA processing
K6V31_RS05895	COG4864	UPF0365 protein
K6V31_RS05900	COG0813	purine-nucleoside phosphorylase activity
K6V31_RS05905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6V31_RS05915	COG4974	Belongs to the 'phage' integrase family
K6V31_RS05975	COG4974	Belongs to the 'phage' integrase family
K6V31_RS05995	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K6V31_RS06010	COG0483	inositol monophosphate 1-phosphatase activity
K6V31_RS06035	COG1063	alcohol dehydrogenase
K6V31_RS06055	COG0564	pseudouridine synthase activity
K6V31_RS06065	COG0346	lactoylglutathione lyase activity
K6V31_RS06075	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6V31_RS06080	COG3695	enzyme binding
K6V31_RS06125	COG0741	lytic transglycosylase activity
K6V31_RS06125	COG1388	LysM domain
K6V31_RS06155	COG1509	lysine 2,3-aminomutase activity
K6V31_RS06170	COG0602	queuosine metabolic process
K6V31_RS06175	COG0720	synthase
K6V31_RS06180	COG2832	Protein of unknown function (DUF454)
K6V31_RS06210	COG1418	mRNA catabolic process
K6V31_RS06215	COG3142	Participates in the control of copper homeostasis
K6V31_RS06240	COG0534	Mate efflux family protein
K6V31_RS06255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6V31_RS06260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V31_RS06275	COG2217	Heavy metal translocating P-type atpase
K6V31_RS06350	COG4667	esterase of the alpha-beta hydrolase superfamily
K6V31_RS06360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6V31_RS06365	COG2086	electron transfer activity
K6V31_RS06370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6V31_RS06385	COG3594	Acyltransferase
K6V31_RS06390	COG0484	heat shock protein binding
K6V31_RS06400	COG0484	heat shock protein binding
K6V31_RS06415	COG0459	protein refolding
K6V31_RS06420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6V31_RS06450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K6V31_RS06455	COG0735	belongs to the Fur family
K6V31_RS06475	COG0514	ATP-dependent DNA helicase (RecQ)
K6V31_RS06485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6V31_RS06505	COG0066	3-isopropylmalate dehydratase activity
K6V31_RS06510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6V31_RS06515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6V31_RS06555	COG3023	N-Acetylmuramoyl-L-alanine amidase
K6V31_RS06570	COG0305	Participates in initiation and elongation during chromosome replication
K6V31_RS06650	COG2207	Transcriptional regulator
K6V31_RS06650	COG1609	Transcriptional regulator
K6V31_RS06660	COG0616	signal peptide processing
K6V31_RS06665	COG1663	tetraacyldisaccharide 4'-kinase activity
K6V31_RS06670	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6V31_RS06675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6V31_RS06730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6V31_RS06735	COG1120	ATPase activity
K6V31_RS06760	COG1192	Involved in chromosome partitioning
K6V31_RS06765	COG1629	transport
K6V31_RS06830	COG4974	Belongs to the 'phage' integrase family
K6V31_RS06835	COG4974	Belongs to the 'phage' integrase family
K6V31_RS06975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6V31_RS06975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6V31_RS07000	COG4413	Urea transporter
K6V31_RS07005	COG1917	Cupin 2, conserved barrel domain protein
K6V31_RS07005	COG4977	sequence-specific DNA binding
K6V31_RS07035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6V31_RS07045	COG0523	cobalamin synthesis protein
K6V31_RS07055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6V31_RS07065	COG0194	GDP metabolic process
K6V31_RS07075	COG1214	PFAM Peptidase M22, glycoprotease
K6V31_RS07085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6V31_RS07090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6V31_RS07100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6V31_RS07110	COG0673	inositol 2-dehydrogenase activity
K6V31_RS07115	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V31_RS07120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K6V31_RS07120	COG4447	cellulose binding
K6V31_RS07135	COG4206	TonB-dependent receptor
K6V31_RS07135	COG1629	transport
K6V31_RS07145	COG0632	four-way junction helicase activity
K6V31_RS07155	COG0006	proline dipeptidase activity
K6V31_RS07180	COG4771	TonB-dependent receptor
K6V31_RS07240	COG1408	metallophosphoesterase
K6V31_RS07245	COG1575	Belongs to the MenA family. Type 1 subfamily
K6V31_RS07255	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6V31_RS07265	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6V31_RS07275	COG0517	IMP dehydrogenase activity
K6V31_RS07275	COG0617	tRNA 3'-terminal CCA addition
K6V31_RS07275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6V31_RS07290	COG4771	TonB-dependent receptor
K6V31_RS07295	COG2204	response regulator
K6V31_RS07300	COG0488	(ABC) transporter
K6V31_RS07305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6V31_RS07340	COG1595	DNA-templated transcription, initiation
K6V31_RS07355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6V31_RS07360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6V31_RS07395	COG0811	peptide transport
K6V31_RS07405	COG0084	hydrolase, TatD family'
K6V31_RS07425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6V31_RS07430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6V31_RS07435	COG0205	6-phosphofructokinase activity
K6V31_RS07455	COG0372	Belongs to the citrate synthase family
K6V31_RS07460	COG0538	isocitrate dehydrogenase activity
K6V31_RS07470	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
K6V31_RS07475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6V31_RS07485	COG0440	acetolactate synthase activity
K6V31_RS07490	COG0028	Belongs to the TPP enzyme family
K6V31_RS07500	COG1047	Peptidyl-prolyl cis-trans
K6V31_RS07505	COG3681	Belongs to the UPF0597 family
K6V31_RS07540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6V31_RS07540	COG0551	DNA topoisomerase type I activity
K6V31_RS07545	COG3408	Glycogen debranching enzyme
K6V31_RS07545	COG3119	arylsulfatase activity
K6V31_RS07565	COG1222	aaa ATPase
K6V31_RS07580	COG1690	Belongs to the RtcB family
K6V31_RS07590	COG2176	DNA-directed DNA polymerase activity
K6V31_RS07630	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V31_RS07640	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V31_RS07640	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V31_RS07645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K6V31_RS07650	COG0569	domain protein
K6V31_RS07650	COG2985	domain, Protein
K6V31_RS07660	COG3119	arylsulfatase activity
K6V31_RS07665	COG3119	arylsulfatase activity
K6V31_RS07675	COG0702	epimerase
K6V31_RS07680	COG4771	TonB-dependent receptor
K6V31_RS07685	COG3292	Two component regulator propeller
K6V31_RS07685	COG0745	RESPONSE REGULATOR receiver
K6V31_RS07685	COG2205	protein histidine kinase activity
K6V31_RS07700	COG3119	arylsulfatase activity
K6V31_RS07710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6V31_RS07715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6V31_RS07720	COG0166	Belongs to the GPI family
K6V31_RS07725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6V31_RS07740	COG2502	aspartate--ammonia ligase
K6V31_RS07745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6V31_RS07760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6V31_RS07770	COG0463	Glycosyl transferase, family 2
K6V31_RS07785	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6V31_RS07795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6V31_RS07800	COG0778	Nitroreductase
K6V31_RS07810	COG1640	4-alpha-glucanotransferase
K6V31_RS07830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6V31_RS07850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V31_RS07855	COG0318	PFAM AMP-dependent synthetase and ligase
K6V31_RS07865	COG0359	binds to the 23S rRNA
K6V31_RS07870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6V31_RS07875	COG0360	Binds together with S18 to 16S ribosomal RNA
K6V31_RS07900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V31_RS07905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6V31_RS07910	COG0363	glucosamine-6-phosphate deaminase activity
K6V31_RS07920	COG1242	4 iron, 4 sulfur cluster binding
K6V31_RS07925	COG2814	Major facilitator Superfamily
K6V31_RS07930	COG0823	Involved in the tonB-independent uptake of proteins
K6V31_RS07930	COG1506	peptidase
K6V31_RS07935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6V31_RS07950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6V31_RS07970	COG0546	phosphoglycolate phosphatase activity
K6V31_RS08010	COG4206	TonB-dependent receptor
K6V31_RS08010	COG1629	transport
K6V31_RS08025	COG1629	transport
K6V31_RS08025	COG4206	TonB-dependent receptor
K6V31_RS08035	COG0745	RESPONSE REGULATOR receiver
K6V31_RS08035	COG2205	protein histidine kinase activity
K6V31_RS08035	COG3292	Two component regulator propeller
K6V31_RS08045	COG3458	cephalosporin-C deacetylase activity
K6V31_RS08050	COG2755	lipolytic protein G-D-S-L family
K6V31_RS08055	COG1917	Cupin 2, conserved barrel domain protein
K6V31_RS08065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V31_RS08070	COG3775	system Galactitol-specific IIC component
K6V31_RS08075	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K6V31_RS08080	COG2271	Major facilitator Superfamily
K6V31_RS08090	COG0805	protein transport
K6V31_RS08095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6V31_RS08100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6V31_RS08110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6V31_RS08115	COG0569	domain protein
K6V31_RS08120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6V31_RS08130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V31_RS08135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V31_RS08140	COG0649	NAD binding
K6V31_RS08140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V31_RS08145	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K6V31_RS08150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V31_RS08155	COG0839	Belongs to the complex I subunit 6 family
K6V31_RS08160	COG0713	ATP synthesis coupled electron transport
K6V31_RS08165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6V31_RS08170	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6V31_RS08180	COG0662	Cupin 2, conserved barrel domain protein
K6V31_RS08180	COG2207	Transcriptional regulator
K6V31_RS08185	COG1312	Catalyzes the dehydration of D-mannonate
K6V31_RS08190	COG1028	Short-chain dehydrogenase reductase Sdr
K6V31_RS08195	COG0784	Response regulator, receiver
K6V31_RS08195	COG2205	protein histidine kinase activity
K6V31_RS08200	COG1404	Belongs to the peptidase S8 family
K6V31_RS08200	COG4412	M6 family metalloprotease domain protein
K6V31_RS08210	COG0668	transmembrane transport
K6V31_RS08220	COG1119	ATPase activity
K6V31_RS08245	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V31_RS08250	COG2755	lipolytic protein G-D-S-L family
K6V31_RS08250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6V31_RS08260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6V31_RS08265	COG2239	Acts as a magnesium transporter
K6V31_RS08270	COG1196	nuclear chromosome segregation
K6V31_RS08275	COG5492	domain, Protein
K6V31_RS08285	COG0799	negative regulation of ribosome biogenesis
K6V31_RS08290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6V31_RS08305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V31_RS08310	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6V31_RS08320	COG1192	Involved in chromosome partitioning
K6V31_RS08325	COG1475	DNA binding
K6V31_RS08335	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6V31_RS08335	COG1388	LysM domain
K6V31_RS08340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6V31_RS08350	COG0739	heme binding
K6V31_RS08380	COG0742	ribosomal rna small subunit methyltransferase
K6V31_RS08385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6V31_RS08400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6V31_RS08415	COG2161	toxin-antitoxin pair type II binding
K6V31_RS08420	COG4115	mRNA cleavage
K6V31_RS08455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6V31_RS08460	COG0823	Involved in the tonB-independent uptake of proteins
K6V31_RS08460	COG1506	peptidase
K6V31_RS08460	COG4946	Tricorn protease homolog
K6V31_RS08475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6V31_RS08495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6V31_RS08535	COG0688	phosphatidylethanolamine metabolic process
K6V31_RS08540	COG1183	phosphatidylcholine synthase activity
K6V31_RS08605	COG4771	TonB-dependent receptor
K6V31_RS08625	COG2814	Major facilitator Superfamily
K6V31_RS08635	COG1940	carbohydrate kinase activity
K6V31_RS08640	COG0792	nuclease activity
K6V31_RS08645	COG2315	Protein conserved in bacteria
K6V31_RS08665	COG0534	Mate efflux family protein
K6V31_RS08670	COG1609	Transcriptional regulator
K6V31_RS08670	COG2207	Transcriptional regulator
K6V31_RS08675	COG2217	Heavy metal translocating P-type atpase
K6V31_RS08680	COG0528	UMP kinase activity
K6V31_RS08685	COG0233	cytoplasmic translational termination
K6V31_RS08695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V31_RS08700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6V31_RS08715	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V31_RS08715	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K6V31_RS08725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6V31_RS08735	COG1629	transport
K6V31_RS08735	COG4206	TonB-dependent receptor
K6V31_RS08740	COG4974	Belongs to the 'phage' integrase family
K6V31_RS08745	COG1629	transport
K6V31_RS08760	COG1629	transport
K6V31_RS08775	COG1629	transport
K6V31_RS08775	COG4206	TonB-dependent receptor
K6V31_RS08785	COG2095	MarC family integral membrane protein
K6V31_RS08800	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6V31_RS08810	COG1435	thymidine kinase activity
K6V31_RS08815	COG0628	permease
K6V31_RS08825	COG0673	inositol 2-dehydrogenase activity
K6V31_RS08840	COG1629	transport
K6V31_RS08840	COG4206	TonB-dependent receptor
K6V31_RS08845	COG0561	phosphatase activity
K6V31_RS08850	COG0673	inositol 2-dehydrogenase activity
K6V31_RS08855	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V31_RS08865	COG0456	acetyltransferase
K6V31_RS08945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6V31_RS08950	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
K6V31_RS08955	COG0460	homoserine dehydrogenase
K6V31_RS08955	COG0527	aspartate kinase activity
K6V31_RS08960	COG0252	asparaginase activity
K6V31_RS08965	COG0288	reversible hydration of carbon dioxide
K6V31_RS08970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6V31_RS08975	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K6V31_RS08980	COG2197	response regulator
K6V31_RS08985	COG4771	TonB-dependent receptor
K6V31_RS08995	COG0826	peptidase U32
K6V31_RS09010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6V31_RS09015	COG0470	DNA polymerase III
K6V31_RS09020	COG1774	PSP1 C-terminal conserved region
K6V31_RS09030	COG0772	Belongs to the SEDS family
K6V31_RS09045	COG1792	Involved in formation and maintenance of cell shape
K6V31_RS09055	COG0138	bifunctional purine biosynthesis protein purh
K6V31_RS09060	COG3590	peptidase
K6V31_RS09065	COG0488	(ABC) transporter
K6V31_RS09090	COG0534	Mate efflux family protein
K6V31_RS09095	COG0612	Peptidase, M16
K6V31_RS09100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6V31_RS09105	COG2204	response regulator
K6V31_RS09110	COG1506	peptidase
K6V31_RS09110	COG0823	Involved in the tonB-independent uptake of proteins
K6V31_RS09115	COG0564	pseudouridine synthase activity
K6V31_RS09150	COG3973	AAA domain
K6V31_RS09185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V31_RS09190	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V31_RS09195	COG1696	Membrane protein involved in D-alanine export
K6V31_RS09235	COG2986	histidine ammonia-lyase
K6V31_RS09245	COG1228	amidohydrolase
K6V31_RS09255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6V31_RS09280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V31_RS09295	COG0203	ribosomal protein L17
K6V31_RS09300	COG0202	RNA polymerase activity
K6V31_RS09305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6V31_RS09310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6V31_RS09315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6V31_RS09320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6V31_RS09325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6V31_RS09340	COG0200	Binds to the 23S rRNA
K6V31_RS09345	COG1841	ribosomal large subunit assembly
K6V31_RS09350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6V31_RS09355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6V31_RS09360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6V31_RS09365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6V31_RS09370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6V31_RS09375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6V31_RS09380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6V31_RS09385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6V31_RS09390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6V31_RS09395	COG0255	Belongs to the universal ribosomal protein uL29 family
K6V31_RS09400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6V31_RS09405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6V31_RS09410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6V31_RS09415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6V31_RS09420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6V31_RS09425	COG0089	rRNA binding
K6V31_RS09430	COG0088	Forms part of the polypeptide exit tunnel
K6V31_RS09435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6V31_RS09440	COG0051	transcription antitermination factor activity, RNA binding
K6V31_RS09445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6V31_RS09450	COG0049	tRNA binding
K6V31_RS09455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K6V31_RS09465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6V31_RS09470	COG0085	RNA polymerase activity
K6V31_RS09475	COG0222	ribosome binding
K6V31_RS09480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6V31_RS09485	COG0081	regulation of translation
K6V31_RS09490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6V31_RS09510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6V31_RS09535	COG4974	Belongs to the 'phage' integrase family
K6V31_RS09540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6V31_RS09545	COG0006	proline dipeptidase activity
K6V31_RS09550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6V31_RS09560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6V31_RS09565	COG1480	7TM receptor with intracellular HD hydrolase
K6V31_RS09575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6V31_RS09580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6V31_RS09595	COG0514	ATP-dependent DNA helicase (RecQ)
K6V31_RS09605	COG2096	Adenosyltransferase
K6V31_RS09620	COG1733	regulation of RNA biosynthetic process
K6V31_RS09675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6V31_RS09685	COG1185	polyribonucleotide nucleotidyltransferase activity
K6V31_RS09700	COG1629	transport
K6V31_RS09700	COG4206	TonB-dependent receptor
K6V31_RS09710	COG3426	butyrate kinase activity
K6V31_RS09715	COG0280	phosphate acetyltransferase
K6V31_RS09725	COG2234	aminopeptidase activity
K6V31_RS09730	COG2166	iron-sulfur cluster assembly
K6V31_RS09735	COG3655	Transcriptional regulator
K6V31_RS09745	COG1266	CAAX protease self-immunity
K6V31_RS09750	COG0196	riboflavin kinase activity
K6V31_RS09755	COG1011	Hydrolase
K6V31_RS09760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6V31_RS09765	COG1773	rubredoxin
K6V31_RS09770	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6V31_RS09780	COG2205	protein histidine kinase activity
K6V31_RS09785	COG0006	proline dipeptidase activity
K6V31_RS09805	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6V31_RS09810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6V31_RS09820	COG0793	Belongs to the peptidase S41A family
K6V31_RS09825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6V31_RS09880	COG1040	competence protein
K6V31_RS09890	COG5652	VanZ like family
K6V31_RS09895	COG2176	DNA-directed DNA polymerase activity
K6V31_RS09905	COG2816	NAD+ diphosphatase activity
K6V31_RS09915	COG4206	TonB-dependent receptor
K6V31_RS09925	COG0018	arginyl-trna synthetase
K6V31_RS09945	COG0708	Exodeoxyribonuclease III
K6V31_RS09950	COG0339	signal peptide processing
K6V31_RS09955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6V31_RS10045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6V31_RS10075	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6V31_RS10075	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6V31_RS10080	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6V31_RS10090	COG4206	TonB-dependent receptor
K6V31_RS10090	COG1629	transport
K6V31_RS10100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6V31_RS10105	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6V31_RS10115	COG1217	gtp-binding protein TYPA
K6V31_RS10120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6V31_RS10140	COG0318	PFAM AMP-dependent synthetase and ligase
K6V31_RS10145	COG1854	S-ribosylhomocysteine lyase activity
K6V31_RS10150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6V31_RS10160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6V31_RS10165	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6V31_RS10180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6V31_RS10185	COG4974	Belongs to the 'phage' integrase family
K6V31_RS10200	COG0606	chelatase, subunit chli
K6V31_RS10220	COG2814	Major facilitator Superfamily
K6V31_RS10240	COG2140	Oxalate decarboxylase
K6V31_RS10260	COG1629	transport
K6V31_RS10260	COG4206	TonB-dependent receptor
K6V31_RS10265	COG2188	Transcriptional regulator
K6V31_RS10290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6V31_RS10290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6V31_RS10295	COG2244	polysaccharide biosynthetic process
K6V31_RS10305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K6V31_RS10315	COG2089	acid synthase
K6V31_RS10330	COG0438	transferase activity, transferring glycosyl groups
K6V31_RS10340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6V31_RS10345	COG0545	Peptidyl-prolyl cis-trans isomerase
K6V31_RS10355	COG1522	sequence-specific DNA binding
K6V31_RS10370	COG4771	TonB-dependent receptor
K6V31_RS10415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6V31_RS10420	COG0793	Belongs to the peptidase S41A family
K6V31_RS10420	COG3409	Peptidoglycan-binding domain 1 protein
K6V31_RS10425	COG0671	phosphoesterase, PA-phosphatase related
K6V31_RS10440	COG1053	succinate dehydrogenase
K6V31_RS10445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6V31_RS10480	COG0826	peptidase U32
K6V31_RS10490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6V31_RS10505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6V31_RS10510	COG0557	exoribonuclease II activity
K6V31_RS10525	COG1045	serine acetyltransferase
K6V31_RS10530	COG0116	Belongs to the methyltransferase superfamily
K6V31_RS10535	COG0823	Involved in the tonB-independent uptake of proteins
K6V31_RS10535	COG1506	peptidase
K6V31_RS10540	COG0151	Belongs to the GarS family
K6V31_RS10555	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K6V31_RS10555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6V31_RS10565	COG1121	(ABC) transporter
K6V31_RS10570	COG3250	beta-galactosidase activity
K6V31_RS10580	COG0702	epimerase
K6V31_RS10585	COG4206	TonB-dependent receptor
K6V31_RS10585	COG1629	transport
K6V31_RS10595	COG1785	Belongs to the alkaline phosphatase family
K6V31_RS10600	COG0745	RESPONSE REGULATOR receiver
K6V31_RS10600	COG2205	protein histidine kinase activity
K6V31_RS10600	COG3292	Two component regulator propeller
K6V31_RS10610	COG0726	polysaccharide deacetylase
K6V31_RS10620	COG1028	Short-chain dehydrogenase reductase Sdr
K6V31_RS10625	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K6V31_RS10635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6V31_RS10645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K6V31_RS10650	COG0594	ribonuclease P activity
K6V31_RS10670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6V31_RS10680	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V31_RS10685	COG1629	transport
K6V31_RS10685	COG4206	TonB-dependent receptor
K6V31_RS10695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6V31_RS10700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V31_RS10705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6V31_RS10710	COG1968	undecaprenyl-diphosphatase activity
K6V31_RS10720	COG2177	Part of the ABC transporter FtsEX involved in
K6V31_RS10725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K6V31_RS10760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6V31_RS10770	COG0427	acetyl-CoA hydrolase
K6V31_RS10795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6V31_RS10800	COG1592	Rubrerythrin
K6V31_RS10805	COG0659	secondary active sulfate transmembrane transporter activity
K6V31_RS10815	COG4771	TonB-dependent receptor
K6V31_RS10860	COG0731	radical SAM domain protein
K6V31_RS10860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V31_RS10885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6V31_RS10890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6V31_RS10895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6V31_RS10900	COG0495	leucyl-tRNA aminoacylation
K6V31_RS10910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6V31_RS10935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V31_RS10940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6V31_RS10955	COG0012	GTP binding
K6V31_RS10970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V31_RS10970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6V31_RS10975	COG0142	geranyltranstransferase activity
K6V31_RS10980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6V31_RS10985	COG1694	Mazg nucleotide pyrophosphohydrolase
K6V31_RS10995	COG0322	excinuclease ABC activity
K6V31_RS11000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6V31_RS11010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6V31_RS11015	COG2715	membrane protein required for spore maturation
K6V31_RS11020	COG2234	aminopeptidase activity
K6V31_RS11030	COG2255	four-way junction helicase activity
K6V31_RS11045	COG3591	Belongs to the peptidase S1B family
K6V31_RS11050	COG3634	alkyl hydroperoxide reductase activity
K6V31_RS11065	COG0783	Belongs to the Dps family
K6V31_RS11075	COG0513	Belongs to the DEAD box helicase family
K6V31_RS11085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6V31_RS11095	COG0612	Peptidase, M16
K6V31_RS11100	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6V31_RS11110	COG1312	Catalyzes the dehydration of D-mannonate
K6V31_RS11115	COG1028	Short-chain dehydrogenase reductase Sdr
K6V31_RS11150	COG0702	epimerase
K6V31_RS11155	COG4771	TonB-dependent receptor
K6V31_RS11170	COG0681	Belongs to the peptidase S26 family
K6V31_RS11180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6V31_RS11195	COG0702	epimerase
K6V31_RS11200	COG4771	TonB-dependent receptor
K6V31_RS11210	COG3119	arylsulfatase activity
K6V31_RS11215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6V31_RS11225	COG0702	epimerase
K6V31_RS11230	COG4771	TonB-dependent receptor
K6V31_RS11235	COG3119	arylsulfatase activity
K6V31_RS11240	COG0745	RESPONSE REGULATOR receiver
K6V31_RS11240	COG2205	protein histidine kinase activity
K6V31_RS11240	COG3292	Two component regulator propeller
K6V31_RS11240	COG3292	Two component regulator propeller
K6V31_RS11240	COG2205	protein histidine kinase activity
K6V31_RS11240	COG0745	RESPONSE REGULATOR receiver
K6V31_RS11255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V31_RS11270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V31_RS11290	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V31_RS11295	COG3119	arylsulfatase activity
K6V31_RS11305	COG0561	phosphatase activity
K6V31_RS11310	COG0482	sulfurtransferase activity
K6V31_RS11320	COG0205	6-phosphofructokinase activity
K6V31_RS11325	COG0571	ribonuclease III activity
K6V31_RS11330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6V31_RS11335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6V31_RS11340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6V31_RS11345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6V31_RS11365	COG1216	Glycosyl transferase, family 2
K6V31_RS11390	COG1442	glycosyl transferase family 8
K6V31_RS11395	COG1215	transferase activity, transferring glycosyl groups
K6V31_RS11400	COG0562	UDP-galactopyranose mutase
K6V31_RS11405	COG1132	(ABC) transporter
K6V31_RS11410	COG3341	Caulimovirus viroplasmin
K6V31_RS11410	COG0328	RNA-DNA hybrid ribonuclease activity
K6V31_RS11420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6V31_RS11425	COG1166	arginine decarboxylase activity
K6V31_RS11430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6V31_RS11435	COG1595	DNA-templated transcription, initiation
K6V31_RS11460	COG0779	Required for maturation of 30S ribosomal subunits
K6V31_RS11465	COG2251	uridine kinase activity
K6V31_RS11465	COG0195	Participates in both transcription termination and antitermination
K6V31_RS11470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6V31_RS11480	COG0719	Fe-S assembly protein
K6V31_RS11485	COG0396	ATPase activity
K6V31_RS11490	COG0719	Fe-S assembly protein
K6V31_RS11495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6V31_RS11500	COG0393	Putative heavy-metal-binding
K6V31_RS11505	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K6V31_RS11510	COG2431	L-lysine efflux transmembrane transporter activity
K6V31_RS11520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6V31_RS11575	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6V31_RS11590	COG0187	DNA topoisomerase II activity
K6V31_RS11595	COG0268	Binds directly to 16S ribosomal RNA
K6V31_RS11605	COG1381	Involved in DNA repair and RecF pathway recombination
K6V31_RS11610	COG1610	YqeY-like protein
K6V31_RS11615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6V31_RS11630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6V31_RS11635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6V31_RS11640	COG0772	Belongs to the SEDS family
K6V31_RS11645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6V31_RS11650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V31_RS11655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6V31_RS11660	COG0768	penicillin binding
K6V31_RS11675	COG2001	Belongs to the MraZ family
K6V31_RS11700	COG0756	dUTP diphosphatase activity
K6V31_RS11715	COG4942	peptidase
K6V31_RS11720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6V31_RS11725	COG1022	Amp-dependent synthetase and ligase
K6V31_RS11735	COG4771	TonB-dependent receptor
K6V31_RS11750	COG0366	Alpha amylase catalytic
K6V31_RS11760	COG1082	Xylose isomerase domain protein TIM barrel
K6V31_RS11775	COG2954	triphosphatase activity
K6V31_RS11800	COG0702	epimerase
K6V31_RS11805	COG4771	TonB-dependent receptor
K6V31_RS11835	COG0423	glycine-tRNA ligase activity
K6V31_RS11845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6V31_RS11850	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6V31_RS11870	COG3876	Protein conserved in bacteria
K6V31_RS11875	COG2807	transmembrane transport
K6V31_RS11890	COG0463	Glycosyl transferase, family 2
K6V31_RS11890	COG1216	Glycosyl transferase, family 2
K6V31_RS11895	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6V31_RS11905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6V31_RS11910	COG3876	Protein conserved in bacteria
K6V31_RS11920	COG4206	TonB-dependent receptor
K6V31_RS11920	COG1629	transport
K6V31_RS11930	COG4206	TonB-dependent receptor
K6V31_RS11930	COG1629	transport
K6V31_RS11945	COG1649	PFAM Uncharacterised BCR, COG1649
K6V31_RS11950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6V31_RS11955	COG0475	glutathione-regulated potassium exporter activity
K6V31_RS11955	COG0589	response to stress
K6V31_RS11960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6V31_RS11965	COG1136	(ABC) transporter
K6V31_RS11975	COG0733	neurotransmitter:sodium symporter activity
K6V31_RS11985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6V31_RS11990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6V31_RS11995	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K6V31_RS12000	COG0312	modulator of DNA gyrase
K6V31_RS12005	COG0312	modulator of DNA gyrase
K6V31_RS12020	COG1346	cytolysis
K6V31_RS12030	COG0280	phosphate acetyltransferase
K6V31_RS12035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6V31_RS12040	COG1785	Belongs to the alkaline phosphatase family
K6V31_RS12050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V31_RS12060	COG2003	Belongs to the UPF0758 family
K6V31_RS12065	COG1216	Glycosyl transferase, family 2
K6V31_RS12065	COG0463	Glycosyl transferase, family 2
K6V31_RS12080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6V31_RS12085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K6V31_RS12090	COG0515	serine threonine protein kinase
K6V31_RS12090	COG2815	serine threonine protein kinase
K6V31_RS12095	COG0564	pseudouridine synthase activity
K6V31_RS12115	COG1349	DNA-binding transcription factor activity
K6V31_RS12120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6V31_RS12130	COG0247	lactate metabolic process
K6V31_RS12135	COG2271	Major facilitator Superfamily
K6V31_RS12140	COG0584	glycerophosphoryl diester phosphodiesterase
K6V31_RS12160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6V31_RS12165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6V31_RS12175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6V31_RS12185	COG0584	glycerophosphoryl diester phosphodiesterase
K6V31_RS12210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6V31_RS12220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V31_RS12220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6V31_RS12225	COG2890	protein-(glutamine-N5) methyltransferase activity
K6V31_RS12235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6V31_RS12265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6V31_RS12270	COG1917	Cupin 2, conserved barrel domain protein
K6V31_RS12270	COG1396	sequence-specific DNA binding
K6V31_RS12275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6V31_RS12280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6V31_RS12285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6V31_RS12295	COG0137	argininosuccinate synthase activity
K6V31_RS12310	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V31_RS12320	COG3401	FG-GAP repeat protein
K6V31_RS12330	COG1070	Carbohydrate kinase
K6V31_RS12335	COG4806	L-rhamnose isomerase
K6V31_RS12345	COG0235	Class ii aldolase
K6V31_RS12350	COG1454	alcohol dehydrogenase
K6V31_RS12365	COG4771	TonB-dependent receptor
K6V31_RS12375	COG3119	arylsulfatase activity
K6V31_RS12380	COG3250	beta-galactosidase activity
K6V31_RS12450	COG0039	L-malate dehydrogenase activity
K6V31_RS12455	COG2996	Protein conserved in bacteria
K6V31_RS12475	COG0577	efflux transmembrane transporter activity
K6V31_RS12475	COG1136	(ABC) transporter
K6V31_RS12480	COG1136	(ABC) transporter
K6V31_RS12480	COG0577	efflux transmembrane transporter activity
K6V31_RS12485	COG0577	efflux transmembrane transporter activity
K6V31_RS12485	COG1136	(ABC) transporter
K6V31_RS12490	COG1940	carbohydrate kinase activity
K6V31_RS12495	COG0335	large ribosomal subunit rRNA binding
K6V31_RS12505	COG0737	Belongs to the 5'-nucleotidase family
K6V31_RS12510	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V31_RS12530	COG1629	transport
K6V31_RS12550	COG1929	Belongs to the glycerate kinase type-1 family
K6V31_RS12555	COG2610	gluconate transmembrane transporter activity
K6V31_RS12600	COG0460	homoserine dehydrogenase
K6V31_RS12600	COG0527	aspartate kinase activity
K6V31_RS12605	COG2204	response regulator
K6V31_RS12615	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K6V31_RS12620	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K6V31_RS12625	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K6V31_RS12635	COG2205	protein histidine kinase activity
K6V31_RS12640	COG5002	protein histidine kinase activity
K6V31_RS12665	COG0724	RNA recognition motif
K6V31_RS12670	COG0513	Belongs to the DEAD box helicase family
K6V31_RS12705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6V31_RS12710	COG0436	Aminotransferase
K6V31_RS12720	COG2202	Pas domain
K6V31_RS12720	COG2205	protein histidine kinase activity
K6V31_RS12725	COG2202	Pas domain
K6V31_RS12725	COG2205	protein histidine kinase activity
K6V31_RS12730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6V31_RS12785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6V31_RS12790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6V31_RS12795	COG1160	GTP binding
K6V31_RS12805	COG4974	Belongs to the 'phage' integrase family
K6V31_RS12810	COG4974	Belongs to the 'phage' integrase family
K6V31_RS12815	COG4974	Belongs to the 'phage' integrase family
K6V31_RS12830	COG0776	regulation of translation
K6V31_RS12880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6V31_RS12890	COG0297	glycogen (starch) synthase activity
K6V31_RS12890	COG0438	transferase activity, transferring glycosyl groups
K6V31_RS12905	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6V31_RS12935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6V31_RS13045	COG0587	DNA-directed DNA polymerase activity
K6V31_RS13065	COG0587	DNA-directed DNA polymerase activity
K6V31_RS13200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6V31_RS13205	COG1120	ATPase activity
K6V31_RS13640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V31_RS13680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6V31_RS13705	COG1127	ABC transporter
K6V31_RS13710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6V31_RS13720	COG0724	RNA recognition motif
K6V31_RS13725	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6V31_RS13730	COG0740	serine-type endopeptidase activity
K6V31_RS13735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6V31_RS13740	COG0514	ATP-dependent DNA helicase (RecQ)
K6V31_RS13745	COG0516	GMP reductase activity
K6V31_RS13745	COG0517	IMP dehydrogenase activity
K6V31_RS13750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6V31_RS13760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6V31_RS13775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6V31_RS13790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6V31_RS13795	COG1011	Hydrolase
K6V31_RS13820	COG1187	pseudouridine synthase activity
K6V31_RS13835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6V31_RS13840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6V31_RS13845	COG0052	Belongs to the universal ribosomal protein uS2 family
K6V31_RS13850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6V31_RS13860	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K6V31_RS13865	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6V31_RS13870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6V31_RS13875	COG1408	metallophosphoesterase
K6V31_RS13895	COG0482	sulfurtransferase activity
K6V31_RS13905	COG1570	exodeoxyribonuclease VII activity
K6V31_RS13925	COG4771	TonB-dependent receptor
K6V31_RS13960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6V31_RS13975	COG0489	protein tyrosine kinase activity
K6V31_RS13980	COG0673	inositol 2-dehydrogenase activity
K6V31_RS14030	COG1629	transport
K6V31_RS14030	COG4206	TonB-dependent receptor
K6V31_RS14040	COG4771	TonB-dependent receptor
K6V31_RS14080	COG1940	carbohydrate kinase activity
K6V31_RS14090	COG3119	arylsulfatase activity
K6V31_RS14100	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6V31_RS14105	COG0702	epimerase
K6V31_RS14110	COG4771	TonB-dependent receptor
K6V31_RS14120	COG5434	Belongs to the glycosyl hydrolase 28 family
K6V31_RS14125	COG0745	RESPONSE REGULATOR receiver
K6V31_RS14125	COG3292	Two component regulator propeller
K6V31_RS14125	COG2205	protein histidine kinase activity
K6V31_RS14160	COG0039	L-malate dehydrogenase activity
K6V31_RS14165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6V31_RS14170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6V31_RS14175	COG0811	peptide transport
K6V31_RS14180	COG0848	biopolymer transport protein
K6V31_RS14200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6V31_RS14205	COG0739	heme binding
K6V31_RS14220	COG0149	triose-phosphate isomerase activity
K6V31_RS14230	COG0302	gtp cyclohydrolase
K6V31_RS14235	COG0358	DNA primase activity
K6V31_RS14245	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K6V31_RS14250	COG0436	Aminotransferase
K6V31_RS14265	COG0514	ATP-dependent DNA helicase (RecQ)
K6V31_RS14270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6V31_RS14270	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K6V31_RS14275	COG3022	response to hydroperoxide
K6V31_RS14280	COG0823	Involved in the tonB-independent uptake of proteins
K6V31_RS14290	COG1629	transport
K6V31_RS14290	COG4206	TonB-dependent receptor
K6V31_RS14300	COG3537	Alpha-1,2-mannosidase
K6V31_RS14305	COG3568	Endonuclease Exonuclease Phosphatase
K6V31_RS14310	COG1785	Belongs to the alkaline phosphatase family
K6V31_RS14325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V31_RS14330	COG2133	pyrroloquinoline quinone binding
K6V31_RS14330	COG5183	chlorophyll binding
K6V31_RS14335	COG1609	Transcriptional regulator
K6V31_RS14335	COG2207	Transcriptional regulator
K6V31_RS14345	COG0009	L-threonylcarbamoyladenylate synthase
K6V31_RS14355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6V31_RS14360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6V31_RS14365	COG0658	competence protein
K6V31_RS14365	COG2333	competence protein COMEC
K6V31_RS14370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6V31_RS14380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6V31_RS14385	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K6V31_RS14390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6V31_RS14400	COG3275	phosphorelay sensor kinase activity
K6V31_RS14405	COG3279	Response regulator of the LytR AlgR family
K6V31_RS14425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6V31_RS14430	COG3250	beta-galactosidase activity
K6V31_RS14440	COG0009	L-threonylcarbamoyladenylate synthase
K6V31_RS14445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6V31_RS14450	COG0561	phosphatase activity
K6V31_RS14455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6V31_RS14480	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V31_RS14500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6V31_RS14500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6V31_RS14505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6V31_RS14510	COG1078	dGTPase activity
K6V31_RS14515	COG0284	orotidine-5'-phosphate decarboxylase activity
K6V31_RS14525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6V31_RS14535	COG1704	LemA family
K6V31_RS14550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6V31_RS14555	COG2226	methyltransferase
K6V31_RS14560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6V31_RS14565	COG1702	phosphate starvation-inducible protein PhoH
K6V31_RS14580	COG1496	oxidoreductase activity
K6V31_RS14585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6V31_RS14595	COG0563	adenylate kinase activity
K6V31_RS14600	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6V31_RS14610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6V31_RS14610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6V31_RS14620	COG0101	tRNA pseudouridine synthase activity
K6V31_RS14640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6V31_RS14645	COG4771	TonB-dependent receptor
K6V31_RS14650	COG0702	epimerase
K6V31_RS14690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6V31_RS14715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6V31_RS14720	COG0793	Belongs to the peptidase S41A family
K6V31_RS14725	COG2131	deaminase
K6V31_RS14735	COG0339	signal peptide processing
K6V31_RS14745	COG1970	mechanosensitive ion channel activity
K6V31_RS14755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6V31_RS14755	COG0519	Catalyzes the synthesis of GMP from XMP
K6V31_RS14775	COG0297	glycogen (starch) synthase activity
K6V31_RS14790	COG0297	glycogen (starch) synthase activity
K6V31_RS14795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6V31_RS14800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K6V31_RS14805	COG0543	2 iron, 2 sulfur cluster binding
K6V31_RS14815	COG5002	protein histidine kinase activity
K6V31_RS14825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6V31_RS14830	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6V31_RS14835	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6V31_RS14840	COG0546	phosphoglycolate phosphatase activity
K6V31_RS14845	COG3537	Alpha-1,2-mannosidase
K6V31_RS14855	COG4771	TonB-dependent receptor
K6V31_RS14875	COG3537	Alpha-1,2-mannosidase
K6V31_RS14880	COG1082	Xylose isomerase domain protein TIM barrel
K6V31_RS14885	COG3537	Alpha-1,2-mannosidase
K6V31_RS14895	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K6V31_RS14900	COG3537	Alpha-1,2-mannosidase
K6V31_RS14905	COG0791	NLP P60 protein
K6V31_RS14910	COG1131	(ABC) transporter
K6V31_RS14920	COG0612	Peptidase, M16
K6V31_RS14925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6V31_RS14930	COG1597	lipid kinase activity
K6V31_RS14935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6V31_RS14940	COG3661	Belongs to the glycosyl hydrolase 67 family
K6V31_RS14955	COG2211	Major facilitator Superfamily
K6V31_RS14980	COG0561	phosphatase activity
K6V31_RS14985	COG4771	TonB-dependent receptor
K6V31_RS14990	COG2205	protein histidine kinase activity
K6V31_RS14990	COG3292	Two component regulator propeller
K6V31_RS14990	COG0745	RESPONSE REGULATOR receiver
K6V31_RS15035	COG2211	Major facilitator Superfamily
K6V31_RS15040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6V31_RS15055	COG1674	ftsk spoiiie
K6V31_RS15065	COG0492	ferredoxin-NADP+ reductase activity
K6V31_RS15100	COG0519	Catalyzes the synthesis of GMP from XMP
K6V31_RS15105	COG1595	DNA-templated transcription, initiation
K6V31_RS15120	COG3956	TIGRFAM MazG family protein
K6V31_RS15135	COG0525	valine-tRNA ligase activity
K6V31_RS15150	COG0653	protein targeting
K6V31_RS15165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K6V31_RS15185	COG1253	flavin adenine dinucleotide binding
K6V31_RS15195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K6V31_RS15205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6V31_RS15210	COG3604	Transcriptional regulator
K6V31_RS15245	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V31_RS15255	COG1621	beta-fructofuranosidase activity
K6V31_RS15265	COG0702	epimerase
K6V31_RS15270	COG4206	TonB-dependent receptor
K6V31_RS15270	COG1629	transport
K6V31_RS15275	COG1621	beta-fructofuranosidase activity
K6V31_RS15280	COG2223	nitrite transmembrane transporter activity
K6V31_RS15290	COG0745	RESPONSE REGULATOR receiver
K6V31_RS15290	COG2205	protein histidine kinase activity
K6V31_RS15290	COG3292	Two component regulator propeller
K6V31_RS15375	COG0358	DNA primase activity
K6V31_RS15515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6V31_RS15515	COG0551	DNA topoisomerase type I activity
K6V31_RS15550	COG4974	Belongs to the 'phage' integrase family
K6V31_RS15555	COG1966	Carbon starvation protein
K6V31_RS15575	COG1649	PFAM Uncharacterised BCR, COG1649
K6V31_RS15590	COG3292	Two component regulator propeller
K6V31_RS15590	COG0745	RESPONSE REGULATOR receiver
K6V31_RS15590	COG2205	protein histidine kinase activity
K6V31_RS15595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6V31_RS15595	COG0047	phosphoribosylformylglycinamidine synthase activity
K6V31_RS15600	COG1280	lysine exporter protein (LysE YggA)
K6V31_RS15620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K6V31_RS15650	COG0511	ligase activity, forming carbon-carbon bonds
K6V31_RS15655	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6V31_RS15670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6V31_RS15675	COG1554	hydrolase, family 65, central catalytic
K6V31_RS15700	COG3250	beta-galactosidase activity
K6V31_RS15705	COG1629	transport
K6V31_RS15705	COG4206	TonB-dependent receptor
K6V31_RS15710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K6V31_RS15725	COG0366	Alpha amylase catalytic
K6V31_RS15735	COG0778	Nitroreductase
K6V31_RS15750	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K6V31_RS15755	COG0424	maF-like protein
K6V31_RS15775	COG4771	TonB-dependent receptor
K6V31_RS15780	COG0702	epimerase
K6V31_RS15805	COG1472	Belongs to the glycosyl hydrolase 3 family
K6V31_RS15815	COG3507	Belongs to the glycosyl hydrolase 43 family
K6V31_RS15820	COG2205	protein histidine kinase activity
K6V31_RS15820	COG3292	Two component regulator propeller
K6V31_RS15820	COG0745	RESPONSE REGULATOR receiver
K6V31_RS15835	COG0126	phosphoglycerate kinase activity
K6V31_RS15840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6V31_RS15845	COG2814	Major facilitator Superfamily
K6V31_RS15850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6V31_RS15855	COG3292	Two component regulator propeller
K6V31_RS15855	COG2205	protein histidine kinase activity
K6V31_RS15855	COG0745	RESPONSE REGULATOR receiver
K6V31_RS15870	COG3469	chitinase activity
K6V31_RS15870	COG3325	Belongs to the glycosyl hydrolase 18 family
K6V31_RS15880	COG4771	TonB-dependent receptor
K6V31_RS15885	COG0702	epimerase
K6V31_RS15890	COG3119	arylsulfatase activity
K6V31_RS15895	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K6V31_RS15915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6V31_RS15920	COG1523	belongs to the glycosyl hydrolase 13 family
K6V31_RS15925	COG1119	ATPase activity
K6V31_RS15940	COG0671	phosphoesterase, PA-phosphatase related
K6V31_RS15945	COG0668	transmembrane transport
K6V31_RS15955	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6V31_RS15975	COG1253	flavin adenine dinucleotide binding
K6V31_RS16000	COG0482	sulfurtransferase activity
K6V31_RS16005	COG2197	response regulator
K6V31_RS16015	COG1757	Na H antiporter
K6V31_RS16030	COG2814	Major facilitator Superfamily
K6V31_RS16065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6V31_RS16070	COG1410	methionine synthase
K6V31_RS16070	COG0646	methionine synthase
K6V31_RS16075	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6V31_RS16080	COG0572	uridine kinase
K6V31_RS16090	COG4232	protein-disulfide reductase activity
K6V31_RS16115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6V31_RS16120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6V31_RS16125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6V31_RS16130	COG0131	Imidazoleglycerol-phosphate dehydratase
K6V31_RS16140	COG2204	response regulator
K6V31_RS16145	COG4191	Histidine kinase
K6V31_RS16170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6V31_RS16180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6V31_RS16190	COG1979	alcohol dehydrogenase
K6V31_RS16195	COG1530	ribonuclease E activity
K6V31_RS16200	COG0776	regulation of translation
K6V31_RS16220	COG4974	Belongs to the 'phage' integrase family
K6V31_RS16230	COG4372	Transposase