locus-tag	class	description
NXX00_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NXX00_RS00010	COG0778	Nitroreductase
NXX00_RS00035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NXX00_RS00055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NXX00_RS00060	COG0318	PFAM AMP-dependent synthetase and ligase
NXX00_RS00095	COG0359	binds to the 23S rRNA
NXX00_RS00100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NXX00_RS00105	COG0360	Binds together with S18 to 16S ribosomal RNA
NXX00_RS00135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NXX00_RS00165	COG1131	(ABC) transporter
NXX00_RS00175	COG2431	L-lysine efflux transmembrane transporter activity
NXX00_RS00185	COG1193	negative regulation of DNA recombination
NXX00_RS00210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NXX00_RS00225	COG2234	aminopeptidase activity
NXX00_RS00230	COG3250	beta-galactosidase activity
NXX00_RS00250	COG0702	epimerase
NXX00_RS00255	COG1629	transport
NXX00_RS00260	COG4206	TonB-dependent receptor
NXX00_RS00260	COG1629	transport
NXX00_RS00275	COG3537	Alpha-1,2-mannosidase
NXX00_RS00290	COG1629	transport
NXX00_RS00290	COG4206	TonB-dependent receptor
NXX00_RS00310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NXX00_RS00315	COG0802	atpase or kinase
NXX00_RS00340	COG0714	Associated with various cellular activities
NXX00_RS00410	COG3118	belongs to the thioredoxin family
NXX00_RS00420	COG0688	phosphatidylethanolamine metabolic process
NXX00_RS00425	COG1183	phosphatidylcholine synthase activity
NXX00_RS00445	COG0792	nuclease activity
NXX00_RS00470	COG0534	Mate efflux family protein
NXX00_RS00475	COG0528	UMP kinase activity
NXX00_RS00510	COG0233	cytoplasmic translational termination
NXX00_RS00515	COG1162	GTPase activity
NXX00_RS00535	COG4771	TonB-dependent receptor
NXX00_RS00540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NXX00_RS00545	COG1131	(ABC) transporter
NXX00_RS00550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NXX00_RS00565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NXX00_RS00585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NXX00_RS00585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NXX00_RS00595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NXX00_RS00605	COG4206	TonB-dependent receptor
NXX00_RS00605	COG1629	transport
NXX00_RS00625	COG1629	transport
NXX00_RS00630	COG4974	Belongs to the 'phage' integrase family
NXX00_RS00635	COG4771	TonB-dependent receptor
NXX00_RS00645	COG2095	MarC family integral membrane protein
NXX00_RS00660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NXX00_RS00670	COG1435	thymidine kinase activity
NXX00_RS00675	COG0628	permease
NXX00_RS00820	COG0693	protein deglycase activity
NXX00_RS00835	COG0534	Mate efflux family protein
NXX00_RS00925	COG2205	protein histidine kinase activity
NXX00_RS00925	COG0745	RESPONSE REGULATOR receiver
NXX00_RS00925	COG3292	Two component regulator propeller
NXX00_RS00940	COG0702	epimerase
NXX00_RS00945	COG1629	transport
NXX00_RS00955	COG4771	TonB-dependent receptor
NXX00_RS00960	COG1595	DNA-templated transcription, initiation
NXX00_RS00965	COG1082	Xylose isomerase domain protein TIM barrel
NXX00_RS00980	COG4771	TonB-dependent receptor
NXX00_RS01015	COG0693	protein deglycase activity
NXX00_RS01090	COG0300	oxidoreductase activity
NXX00_RS01100	COG0110	maltose O-acetyltransferase activity
NXX00_RS01110	COG1522	sequence-specific DNA binding
NXX00_RS01140	COG2205	protein histidine kinase activity
NXX00_RS01140	COG0745	RESPONSE REGULATOR receiver
NXX00_RS01140	COG3292	Two component regulator propeller
NXX00_RS01150	COG1629	transport
NXX00_RS01180	COG2818	Glycosylase
NXX00_RS01195	COG0460	homoserine dehydrogenase
NXX00_RS01195	COG0527	aspartate kinase activity
NXX00_RS01200	COG0252	asparaginase activity
NXX00_RS01210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NXX00_RS01215	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NXX00_RS01245	COG0826	peptidase U32
NXX00_RS01250	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NXX00_RS01260	COG0436	Aminotransferase
NXX00_RS01265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NXX00_RS01285	COG0519	Catalyzes the synthesis of GMP from XMP
NXX00_RS01290	COG5002	protein histidine kinase activity
NXX00_RS01295	COG2205	protein histidine kinase activity
NXX00_RS01305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NXX00_RS01315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NXX00_RS01360	COG3250	beta-galactosidase activity
NXX00_RS01365	COG2204	response regulator
NXX00_RS01370	COG0446	pyridine nucleotide-disulphide oxidoreductase
NXX00_RS01400	COG0737	Belongs to the 5'-nucleotidase family
NXX00_RS01440	COG4974	Belongs to the 'phage' integrase family
NXX00_RS01445	COG4974	Belongs to the 'phage' integrase family
NXX00_RS01475	COG0010	Belongs to the arginase family
NXX00_RS01480	COG0058	SHG alpha-glucan phosphorylase activity
NXX00_RS01490	COG0205	6-phosphofructokinase activity
NXX00_RS01505	COG0588	phosphoglycerate mutase activity
NXX00_RS01510	COG1830	Aldolase
NXX00_RS01520	COG2095	MarC family integral membrane protein
NXX00_RS01555	COG1477	protein flavinylation
NXX00_RS01575	COG0335	large ribosomal subunit rRNA binding
NXX00_RS01585	COG1940	carbohydrate kinase activity
NXX00_RS01590	COG1136	(ABC) transporter
NXX00_RS01590	COG0577	efflux transmembrane transporter activity
NXX00_RS01595	COG0577	efflux transmembrane transporter activity
NXX00_RS01595	COG1136	(ABC) transporter
NXX00_RS01600	COG1136	(ABC) transporter
NXX00_RS01600	COG0577	efflux transmembrane transporter activity
NXX00_RS01605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NXX00_RS01625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NXX00_RS01645	COG2996	Protein conserved in bacteria
NXX00_RS01650	COG0039	L-malate dehydrogenase activity
NXX00_RS01660	COG2217	Heavy metal translocating P-type atpase
NXX00_RS01680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NXX00_RS01685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NXX00_RS01690	COG0509	glycine decarboxylation via glycine cleavage system
NXX00_RS01705	COG0514	ATP-dependent DNA helicase (RecQ)
NXX00_RS01720	COG0006	proline dipeptidase activity
NXX00_RS01725	COG3250	beta-galactosidase activity
NXX00_RS01740	COG3458	cephalosporin-C deacetylase activity
NXX00_RS01755	COG1283	sodium-dependent phosphate transmembrane transporter activity
NXX00_RS01775	COG4206	TonB-dependent receptor
NXX00_RS01775	COG1629	transport
NXX00_RS01815	COG1773	rubredoxin
NXX00_RS01820	COG2205	protein histidine kinase activity
NXX00_RS01820	COG2202	Pas domain
NXX00_RS01825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NXX00_RS01830	COG1011	Hydrolase
NXX00_RS01835	COG0196	riboflavin kinase activity
NXX00_RS01840	COG1266	CAAX protease self-immunity
NXX00_RS01850	COG3655	Transcriptional regulator
NXX00_RS01855	COG2166	iron-sulfur cluster assembly
NXX00_RS01865	COG1619	proteins homologs of microcin C7 resistance protein MccF
NXX00_RS01875	COG0280	phosphate acetyltransferase
NXX00_RS01880	COG3426	butyrate kinase activity
NXX00_RS01915	COG1629	transport
NXX00_RS01915	COG4206	TonB-dependent receptor
NXX00_RS01930	COG1185	polyribonucleotide nucleotidyltransferase activity
NXX00_RS01940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NXX00_RS01960	COG1595	DNA-templated transcription, initiation
NXX00_RS01965	COG0076	glutamate decarboxylase activity
NXX00_RS01980	COG0531	amino acid
NXX00_RS02130	COG0667	Aldo Keto reductase
NXX00_RS02135	COG3250	beta-galactosidase activity
NXX00_RS02165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NXX00_RS02175	COG1309	transcriptional regulator
NXX00_RS02180	COG2986	histidine ammonia-lyase
NXX00_RS02190	COG1228	amidohydrolase
NXX00_RS02210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NXX00_RS02225	COG0203	ribosomal protein L17
NXX00_RS02230	COG0202	RNA polymerase activity
NXX00_RS02235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NXX00_RS02240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NXX00_RS02245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NXX00_RS02250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NXX00_RS02255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NXX00_RS02270	COG0200	Binds to the 23S rRNA
NXX00_RS02275	COG1841	ribosomal large subunit assembly
NXX00_RS02280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NXX00_RS02285	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NXX00_RS02290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NXX00_RS02295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NXX00_RS02300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NXX00_RS02305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NXX00_RS02310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NXX00_RS02315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NXX00_RS02320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NXX00_RS02325	COG0255	Belongs to the universal ribosomal protein uL29 family
NXX00_RS02330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NXX00_RS02335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NXX00_RS02340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NXX00_RS02350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NXX00_RS02355	COG0089	rRNA binding
NXX00_RS02360	COG0088	Forms part of the polypeptide exit tunnel
NXX00_RS02365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NXX00_RS02370	COG0051	transcription antitermination factor activity, RNA binding
NXX00_RS02375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NXX00_RS02380	COG0049	tRNA binding
NXX00_RS02385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NXX00_RS02395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NXX00_RS02400	COG0085	RNA polymerase activity
NXX00_RS02405	COG0222	ribosome binding
NXX00_RS02410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NXX00_RS02415	COG0081	regulation of translation
NXX00_RS02420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NXX00_RS02430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NXX00_RS02440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NXX00_RS02470	COG4974	Belongs to the 'phage' integrase family
NXX00_RS02475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NXX00_RS02480	COG0006	proline dipeptidase activity
NXX00_RS02485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NXX00_RS02510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NXX00_RS02520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NXX00_RS02530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NXX00_RS02545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NXX00_RS02550	COG1027	Aspartate ammonia-lyase
NXX00_RS02555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NXX00_RS02560	COG0252	asparaginase activity
NXX00_RS02580	COG2096	Adenosyltransferase
NXX00_RS02595	COG3279	Response regulator of the LytR AlgR family
NXX00_RS02615	COG0515	serine threonine protein kinase
NXX00_RS02615	COG2815	serine threonine protein kinase
NXX00_RS02635	COG2815	serine threonine protein kinase
NXX00_RS02635	COG0515	serine threonine protein kinase
NXX00_RS02645	COG0631	protein serine/threonine phosphatase activity
NXX00_RS02700	COG0358	DNA primase activity
NXX00_RS02720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NXX00_RS02735	COG0662	Cupin 2, conserved barrel domain protein
NXX00_RS02735	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NXX00_RS02740	COG0318	PFAM AMP-dependent synthetase and ligase
NXX00_RS02745	COG1396	sequence-specific DNA binding
NXX00_RS02750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NXX00_RS02765	COG2059	Chromate
NXX00_RS02770	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NXX00_RS02775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NXX00_RS02805	COG3292	Two component regulator propeller
NXX00_RS02805	COG2205	protein histidine kinase activity
NXX00_RS02805	COG0745	RESPONSE REGULATOR receiver
NXX00_RS02835	COG0702	epimerase
NXX00_RS02840	COG4771	TonB-dependent receptor
NXX00_RS02860	COG4948	Mandelate Racemase Muconate Lactonizing
NXX00_RS02875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NXX00_RS02880	COG2205	protein histidine kinase activity
NXX00_RS02880	COG3437	response regulator, receiver
NXX00_RS02880	COG3850	Histidine kinase
NXX00_RS02880	COG4999	Histidine kinase
NXX00_RS02890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NXX00_RS02910	COG0483	inositol monophosphate 1-phosphatase activity
NXX00_RS02920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NXX00_RS02925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NXX00_RS02930	COG4771	TonB-dependent receptor
NXX00_RS02935	COG0702	epimerase
NXX00_RS02965	COG3634	alkyl hydroperoxide reductase activity
NXX00_RS02975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NXX00_RS02980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NXX00_RS02985	COG2816	NAD+ diphosphatase activity
NXX00_RS03000	COG1629	transport
NXX00_RS03105	COG3292	Two component regulator propeller
NXX00_RS03105	COG0745	RESPONSE REGULATOR receiver
NXX00_RS03105	COG2205	protein histidine kinase activity
NXX00_RS03120	COG0018	arginyl-trna synthetase
NXX00_RS03130	COG0705	Rhomboid family
NXX00_RS03145	COG0339	signal peptide processing
NXX00_RS03150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NXX00_RS03160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NXX00_RS03160	COG0674	pyruvate-flavodoxin oxidoreductase activity
NXX00_RS03165	COG1013	pyruvate-flavodoxin oxidoreductase activity
NXX00_RS03170	COG4591	ABC-type transport system involved in lipoprotein release permease component
NXX00_RS03175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NXX00_RS03195	COG4974	Belongs to the 'phage' integrase family
NXX00_RS03210	COG0606	chelatase, subunit chli
NXX00_RS03235	COG2205	protein histidine kinase activity
NXX00_RS03255	COG1472	Belongs to the glycosyl hydrolase 3 family
NXX00_RS03275	COG0561	phosphatase activity
NXX00_RS03280	COG1629	transport
NXX00_RS03280	COG4206	TonB-dependent receptor
NXX00_RS03285	COG2205	protein histidine kinase activity
NXX00_RS03285	COG3292	Two component regulator propeller
NXX00_RS03285	COG2205	protein histidine kinase activity
NXX00_RS03285	COG0745	RESPONSE REGULATOR receiver
NXX00_RS03285	COG0745	RESPONSE REGULATOR receiver
NXX00_RS03285	COG3292	Two component regulator propeller
NXX00_RS03310	COG0438	transferase activity, transferring glycosyl groups
NXX00_RS03315	COG0438	transferase activity, transferring glycosyl groups
NXX00_RS03330	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS03335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NXX00_RS03355	COG1442	glycosyl transferase family 8
NXX00_RS03370	COG1216	Glycosyl transferase, family 2
NXX00_RS03370	COG1442	glycosyl transferase family 8
NXX00_RS03405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NXX00_RS03425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NXX00_RS03430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NXX00_RS03460	COG4771	TonB-dependent receptor
NXX00_RS03475	COG0745	RESPONSE REGULATOR receiver
NXX00_RS03475	COG2205	protein histidine kinase activity
NXX00_RS03475	COG3292	Two component regulator propeller
NXX00_RS03515	COG1629	transport
NXX00_RS03550	COG3940	Belongs to the glycosyl hydrolase 43 family
NXX00_RS03555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NXX00_RS03560	COG3119	arylsulfatase activity
NXX00_RS03590	COG0702	epimerase
NXX00_RS03605	COG3250	beta-galactosidase activity
NXX00_RS03670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NXX00_RS03670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NXX00_RS03690	COG0438	transferase activity, transferring glycosyl groups
NXX00_RS03700	COG0438	transferase activity, transferring glycosyl groups
NXX00_RS03730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NXX00_RS03735	COG0438	transferase activity, transferring glycosyl groups
NXX00_RS03740	COG1216	Glycosyl transferase, family 2
NXX00_RS03760	COG0702	epimerase
NXX00_RS03765	COG1629	transport
NXX00_RS03790	COG5492	domain, Protein
NXX00_RS03805	COG0702	epimerase
NXX00_RS03810	COG4771	TonB-dependent receptor
NXX00_RS03815	COG3250	beta-galactosidase activity
NXX00_RS03825	COG0745	RESPONSE REGULATOR receiver
NXX00_RS03825	COG2205	protein histidine kinase activity
NXX00_RS03825	COG2205	protein histidine kinase activity
NXX00_RS03825	COG3292	Two component regulator propeller
NXX00_RS03825	COG3292	Two component regulator propeller
NXX00_RS03825	COG0745	RESPONSE REGULATOR receiver
NXX00_RS03845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NXX00_RS03850	COG0545	Peptidyl-prolyl cis-trans isomerase
NXX00_RS03855	COG0545	Peptidyl-prolyl cis-trans isomerase
NXX00_RS03900	COG1472	Belongs to the glycosyl hydrolase 3 family
NXX00_RS03910	COG0582	viral genome integration into host DNA
NXX00_RS03945	COG0656	L-ascorbic acid biosynthetic process
NXX00_RS03970	COG2205	protein histidine kinase activity
NXX00_RS03970	COG2198	Histidine kinase
NXX00_RS03970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NXX00_RS03970	COG0784	Response regulator, receiver
NXX00_RS03985	COG1629	transport
NXX00_RS03990	COG0561	phosphatase activity
NXX00_RS04040	COG4771	TonB-dependent receptor
NXX00_RS04060	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
NXX00_RS04065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NXX00_RS04085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NXX00_RS04145	COG1629	transport
NXX00_RS04160	COG2205	protein histidine kinase activity
NXX00_RS04160	COG0745	RESPONSE REGULATOR receiver
NXX00_RS04160	COG3292	Two component regulator propeller
NXX00_RS04170	COG3119	arylsulfatase activity
NXX00_RS04185	COG1053	succinate dehydrogenase
NXX00_RS04190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NXX00_RS04200	COG3119	arylsulfatase activity
NXX00_RS04245	COG3345	alpha-galactosidase
NXX00_RS04270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NXX00_RS04270	COG0758	DNA mediated transformation
NXX00_RS04280	COG0826	peptidase U32
NXX00_RS04285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NXX00_RS04300	COG0557	exoribonuclease II activity
NXX00_RS04325	COG1917	Cupin 2, conserved barrel domain protein
NXX00_RS04330	COG1621	beta-fructofuranosidase activity
NXX00_RS04340	COG1501	Belongs to the glycosyl hydrolase 31 family
NXX00_RS04360	COG0702	epimerase
NXX00_RS04365	COG4771	TonB-dependent receptor
NXX00_RS04390	COG3119	arylsulfatase activity
NXX00_RS04390	COG3408	Glycogen debranching enzyme
NXX00_RS04405	COG3292	Two component regulator propeller
NXX00_RS04405	COG0745	RESPONSE REGULATOR receiver
NXX00_RS04405	COG2205	protein histidine kinase activity
NXX00_RS04430	COG3119	arylsulfatase activity
NXX00_RS04445	COG4771	TonB-dependent receptor
NXX00_RS04470	COG3119	arylsulfatase activity
NXX00_RS04485	COG1073	alpha beta
NXX00_RS04490	COG2814	Major facilitator Superfamily
NXX00_RS04510	COG0012	GTP binding
NXX00_RS04515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NXX00_RS04520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NXX00_RS04540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NXX00_RS04545	COG0662	Cupin 2, conserved barrel domain protein
NXX00_RS04545	COG2207	Transcriptional regulator
NXX00_RS04550	COG0697	spore germination
NXX00_RS04685	COG3344	reverse transcriptase
NXX00_RS04815	COG4974	Belongs to the 'phage' integrase family
NXX00_RS04835	COG0551	DNA topoisomerase type I activity
NXX00_RS04835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NXX00_RS04850	COG4804	nuclease activity
NXX00_RS04880	COG0495	leucyl-tRNA aminoacylation
NXX00_RS04885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NXX00_RS04890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NXX00_RS04895	COG1360	Flagellar Motor Protein
NXX00_RS04900	COG3537	Alpha-1,2-mannosidase
NXX00_RS04920	COG2205	protein histidine kinase activity
NXX00_RS04920	COG0745	RESPONSE REGULATOR receiver
NXX00_RS04920	COG3292	Two component regulator propeller
NXX00_RS04920	COG2205	protein histidine kinase activity
NXX00_RS04920	COG0745	RESPONSE REGULATOR receiver
NXX00_RS04920	COG3292	Two component regulator propeller
NXX00_RS04935	COG1629	transport
NXX00_RS04955	COG5434	Belongs to the glycosyl hydrolase 28 family
NXX00_RS04965	COG0584	glycerophosphoryl diester phosphodiesterase
NXX00_RS04970	COG4948	Mandelate Racemase Muconate Lactonizing
NXX00_RS04975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NXX00_RS04995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NXX00_RS04995	COG0731	radical SAM domain protein
NXX00_RS05015	COG3292	Two component regulator propeller
NXX00_RS05015	COG2205	protein histidine kinase activity
NXX00_RS05015	COG0745	RESPONSE REGULATOR receiver
NXX00_RS05015	COG3292	Two component regulator propeller
NXX00_RS05015	COG2205	protein histidine kinase activity
NXX00_RS05015	COG0745	RESPONSE REGULATOR receiver
NXX00_RS05025	COG4206	TonB-dependent receptor
NXX00_RS05025	COG1629	transport
NXX00_RS05045	COG3119	arylsulfatase activity
NXX00_RS05050	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS05055	COG3250	beta-galactosidase activity
NXX00_RS05065	COG0659	secondary active sulfate transmembrane transporter activity
NXX00_RS05070	COG1592	Rubrerythrin
NXX00_RS05125	COG0427	acetyl-CoA hydrolase
NXX00_RS05135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NXX00_RS05160	COG3023	N-Acetylmuramoyl-L-alanine amidase
NXX00_RS05175	COG3209	COG3209 Rhs family protein
NXX00_RS05205	COG2177	Part of the ABC transporter FtsEX involved in
NXX00_RS05215	COG1968	undecaprenyl-diphosphatase activity
NXX00_RS05225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NXX00_RS05230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NXX00_RS05245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NXX00_RS05270	COG1611	Belongs to the LOG family
NXX00_RS05285	COG0594	ribonuclease P activity
NXX00_RS05290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NXX00_RS05300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NXX00_RS05310	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NXX00_RS05315	COG1028	Short-chain dehydrogenase reductase Sdr
NXX00_RS05355	COG1629	transport
NXX00_RS05355	COG4206	TonB-dependent receptor
NXX00_RS05380	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NXX00_RS05395	COG1121	(ABC) transporter
NXX00_RS05405	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NXX00_RS05405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NXX00_RS05410	COG1238	metal cluster binding
NXX00_RS05425	COG0823	Involved in the tonB-independent uptake of proteins
NXX00_RS05425	COG1506	peptidase
NXX00_RS05430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NXX00_RS05430	COG0116	Belongs to the methyltransferase superfamily
NXX00_RS05435	COG1045	serine acetyltransferase
NXX00_RS05440	COG3275	phosphorelay sensor kinase activity
NXX00_RS05445	COG3279	Response regulator of the LytR AlgR family
NXX00_RS05455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NXX00_RS05455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NXX00_RS05460	COG0142	geranyltranstransferase activity
NXX00_RS05480	COG1490	D-aminoacyl-tRNA deacylase activity
NXX00_RS05490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NXX00_RS05495	COG0445	tRNA wobble uridine modification
NXX00_RS05510	COG4206	TonB-dependent receptor
NXX00_RS05510	COG1629	transport
NXX00_RS05540	COG2197	response regulator
NXX00_RS05550	COG1629	transport
NXX00_RS05550	COG4206	TonB-dependent receptor
NXX00_RS05570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NXX00_RS05575	COG0700	Nucleoside recognition
NXX00_RS05580	COG2255	four-way junction helicase activity
NXX00_RS05600	COG3591	Belongs to the peptidase S1B family
NXX00_RS05625	COG4948	Mandelate Racemase Muconate Lactonizing
NXX00_RS05650	COG0702	epimerase
NXX00_RS05655	COG4771	TonB-dependent receptor
NXX00_RS05675	COG0745	RESPONSE REGULATOR receiver
NXX00_RS05675	COG2205	protein histidine kinase activity
NXX00_RS05675	COG3292	Two component regulator propeller
NXX00_RS05680	COG0513	Belongs to the DEAD box helicase family
NXX00_RS05705	COG0612	Peptidase, M16
NXX00_RS05715	COG4771	TonB-dependent receptor
NXX00_RS05720	COG0702	epimerase
NXX00_RS05735	COG1472	Belongs to the glycosyl hydrolase 3 family
NXX00_RS05740	COG0562	UDP-galactopyranose mutase
NXX00_RS05760	COG0463	Glycosyl transferase, family 2
NXX00_RS05785	COG0297	glycogen (starch) synthase activity
NXX00_RS05810	COG0681	Belongs to the peptidase S26 family
NXX00_RS05820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NXX00_RS05830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NXX00_RS05840	COG5492	domain, Protein
NXX00_RS05855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NXX00_RS05880	COG0702	epimerase
NXX00_RS05885	COG4771	TonB-dependent receptor
NXX00_RS05895	COG0745	RESPONSE REGULATOR receiver
NXX00_RS05895	COG2205	protein histidine kinase activity
NXX00_RS05895	COG2205	protein histidine kinase activity
NXX00_RS05895	COG3292	Two component regulator propeller
NXX00_RS05895	COG0745	RESPONSE REGULATOR receiver
NXX00_RS05895	COG3292	Two component regulator propeller
NXX00_RS05905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NXX00_RS05910	COG1538	Outer membrane efflux protein
NXX00_RS05920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NXX00_RS05925	COG3250	beta-galactosidase activity
NXX00_RS05950	COG0702	epimerase
NXX00_RS05955	COG4771	TonB-dependent receptor
NXX00_RS05965	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NXX00_RS05970	COG3119	arylsulfatase activity
NXX00_RS05975	COG5492	domain, Protein
NXX00_RS05980	COG0215	cysteine-tRNA ligase activity
NXX00_RS05985	COG0561	phosphatase activity
NXX00_RS05990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NXX00_RS05995	COG0482	sulfurtransferase activity
NXX00_RS06005	COG0205	6-phosphofructokinase activity
NXX00_RS06010	COG0571	ribonuclease III activity
NXX00_RS06015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NXX00_RS06020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NXX00_RS06030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NXX00_RS06060	COG1216	Glycosyl transferase, family 2
NXX00_RS06060	COG1442	glycosyl transferase family 8
NXX00_RS06085	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS06105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NXX00_RS06110	COG0436	Aminotransferase
NXX00_RS06130	COG0463	Glycosyl transferase, family 2
NXX00_RS06170	COG1132	(ABC) transporter
NXX00_RS06195	COG0328	RNA-DNA hybrid ribonuclease activity
NXX00_RS06195	COG3341	Caulimovirus viroplasmin
NXX00_RS06205	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NXX00_RS06210	COG1166	arginine decarboxylase activity
NXX00_RS06215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NXX00_RS06220	COG1595	DNA-templated transcription, initiation
NXX00_RS06245	COG0779	Required for maturation of 30S ribosomal subunits
NXX00_RS06250	COG0195	Participates in both transcription termination and antitermination
NXX00_RS06255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NXX00_RS06265	COG0719	Fe-S assembly protein
NXX00_RS06270	COG0396	ATPase activity
NXX00_RS06275	COG0719	Fe-S assembly protein
NXX00_RS06280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NXX00_RS06285	COG0393	Putative heavy-metal-binding
NXX00_RS06295	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NXX00_RS06300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NXX00_RS06315	COG5433	transposase activity
NXX00_RS06325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NXX00_RS06340	COG0187	DNA topoisomerase II activity
NXX00_RS06345	COG0268	Binds directly to 16S ribosomal RNA
NXX00_RS06360	COG1381	Involved in DNA repair and RecF pathway recombination
NXX00_RS06415	COG1610	YqeY-like protein
NXX00_RS06420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NXX00_RS06435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NXX00_RS06440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NXX00_RS06445	COG0772	Belongs to the SEDS family
NXX00_RS06450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NXX00_RS06460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NXX00_RS06465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NXX00_RS06480	COG0275	rRNA processing
NXX00_RS06485	COG2001	Belongs to the MraZ family
NXX00_RS06490	COG1595	DNA-templated transcription, initiation
NXX00_RS06505	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NXX00_RS06510	COG0756	dUTP diphosphatase activity
NXX00_RS06525	COG4942	peptidase
NXX00_RS06530	COG2205	protein histidine kinase activity
NXX00_RS06530	COG0745	RESPONSE REGULATOR receiver
NXX00_RS06530	COG3292	Two component regulator propeller
NXX00_RS06550	COG0673	inositol 2-dehydrogenase activity
NXX00_RS06560	COG0673	inositol 2-dehydrogenase activity
NXX00_RS06570	COG0702	epimerase
NXX00_RS06575	COG4771	TonB-dependent receptor
NXX00_RS06605	COG0702	epimerase
NXX00_RS06610	COG4771	TonB-dependent receptor
NXX00_RS06645	COG3119	arylsulfatase activity
NXX00_RS06660	COG1629	transport
NXX00_RS06705	COG0702	epimerase
NXX00_RS06710	COG4771	TonB-dependent receptor
NXX00_RS06740	COG4771	TonB-dependent receptor
NXX00_RS06745	COG0702	epimerase
NXX00_RS06815	COG1629	transport
NXX00_RS06820	COG0561	phosphatase activity
NXX00_RS06855	COG3537	Alpha-1,2-mannosidase
NXX00_RS06870	COG3537	Alpha-1,2-mannosidase
NXX00_RS06880	COG2017	converts alpha-aldose to the beta-anomer
NXX00_RS06905	COG1373	ATPase (AAA superfamily
NXX00_RS06910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NXX00_RS06915	COG1022	Amp-dependent synthetase and ligase
NXX00_RS06925	COG0612	Peptidase, M16
NXX00_RS06945	COG2954	triphosphatase activity
NXX00_RS07005	COG1472	Belongs to the glycosyl hydrolase 3 family
NXX00_RS07015	COG4771	TonB-dependent receptor
NXX00_RS07070	COG0673	inositol 2-dehydrogenase activity
NXX00_RS07075	COG0673	inositol 2-dehydrogenase activity
NXX00_RS07095	COG0363	glucosamine-6-phosphate deaminase activity
NXX00_RS07100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NXX00_RS07120	COG3345	alpha-galactosidase
NXX00_RS07150	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS07165	COG0673	inositol 2-dehydrogenase activity
NXX00_RS07170	COG0673	inositol 2-dehydrogenase activity
NXX00_RS07180	COG0702	epimerase
NXX00_RS07185	COG4771	TonB-dependent receptor
NXX00_RS07195	COG2814	Major facilitator Superfamily
NXX00_RS07205	COG3458	cephalosporin-C deacetylase activity
NXX00_RS07210	COG1609	Transcriptional regulator
NXX00_RS07210	COG2207	Transcriptional regulator
NXX00_RS07220	COG0423	glycine-tRNA ligase activity
NXX00_RS07235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NXX00_RS07235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NXX00_RS07250	COG1609	Transcriptional regulator
NXX00_RS07265	COG0738	Major facilitator superfamily
NXX00_RS07270	COG1063	alcohol dehydrogenase
NXX00_RS07285	COG2211	Major facilitator Superfamily
NXX00_RS07290	COG2247	cell wall binding repeat
NXX00_RS07290	COG2385	sporulation resulting in formation of a cellular spore
NXX00_RS07295	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS07300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NXX00_RS07355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NXX00_RS07365	COG0589	response to stress
NXX00_RS07365	COG0475	glutathione-regulated potassium exporter activity
NXX00_RS07370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NXX00_RS07375	COG1136	(ABC) transporter
NXX00_RS07385	COG0733	neurotransmitter:sodium symporter activity
NXX00_RS07395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NXX00_RS07400	COG5002	protein histidine kinase activity
NXX00_RS07400	COG0784	Response regulator, receiver
NXX00_RS07405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NXX00_RS07410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NXX00_RS07415	COG0312	modulator of DNA gyrase
NXX00_RS07420	COG0312	modulator of DNA gyrase
NXX00_RS07425	COG1704	LemA family
NXX00_RS07455	COG3507	Belongs to the glycosyl hydrolase 43 family
NXX00_RS07465	COG1501	Belongs to the glycosyl hydrolase 31 family
NXX00_RS07475	COG4948	Mandelate Racemase Muconate Lactonizing
NXX00_RS07505	COG3507	Belongs to the glycosyl hydrolase 43 family
NXX00_RS07510	COG1082	Xylose isomerase domain protein TIM barrel
NXX00_RS07540	COG3292	Two component regulator propeller
NXX00_RS07540	COG2205	protein histidine kinase activity
NXX00_RS07540	COG0745	RESPONSE REGULATOR receiver
NXX00_RS07565	COG4771	TonB-dependent receptor
NXX00_RS07615	COG1380	Effector of murein hydrolase LrgA
NXX00_RS07620	COG0280	phosphate acetyltransferase
NXX00_RS07625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NXX00_RS07630	COG1216	Glycosyl transferase, family 2
NXX00_RS07630	COG0463	Glycosyl transferase, family 2
NXX00_RS07635	COG2003	Belongs to the UPF0758 family
NXX00_RS07645	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NXX00_RS07650	COG0366	Alpha amylase catalytic
NXX00_RS07665	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NXX00_RS07670	COG4206	TonB-dependent receptor
NXX00_RS07670	COG1629	transport
NXX00_RS07675	COG1082	Xylose isomerase domain protein TIM barrel
NXX00_RS07680	COG0366	Alpha amylase catalytic
NXX00_RS07690	COG1785	Belongs to the alkaline phosphatase family
NXX00_RS07695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NXX00_RS07700	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NXX00_RS07705	COG2815	serine threonine protein kinase
NXX00_RS07705	COG0515	serine threonine protein kinase
NXX00_RS07710	COG0564	pseudouridine synthase activity
NXX00_RS07715	COG1181	Belongs to the D-alanine--D-alanine ligase family
NXX00_RS07735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NXX00_RS07740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NXX00_RS07745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NXX00_RS07750	COG0436	Aminotransferase
NXX00_RS07760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NXX00_RS07775	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NXX00_RS07780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NXX00_RS07790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NXX00_RS07790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NXX00_RS07795	COG2890	protein-(glutamine-N5) methyltransferase activity
NXX00_RS07805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NXX00_RS07815	COG0165	Argininosuccinate lyase
NXX00_RS07830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NXX00_RS07850	COG3292	Two component regulator propeller
NXX00_RS07850	COG0745	RESPONSE REGULATOR receiver
NXX00_RS07850	COG2205	protein histidine kinase activity
NXX00_RS07850	COG3292	Two component regulator propeller
NXX00_RS07850	COG2205	protein histidine kinase activity
NXX00_RS07850	COG0745	RESPONSE REGULATOR receiver
NXX00_RS07855	COG0471	metal ion transport
NXX00_RS07910	COG4771	TonB-dependent receptor
NXX00_RS07935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NXX00_RS07940	COG1396	sequence-specific DNA binding
NXX00_RS07940	COG1917	Cupin 2, conserved barrel domain protein
NXX00_RS07945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NXX00_RS07950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NXX00_RS07955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NXX00_RS07960	COG0137	argininosuccinate synthase activity
NXX00_RS07970	COG1438	arginine binding
NXX00_RS07975	COG1070	Carbohydrate kinase
NXX00_RS07980	COG4806	L-rhamnose isomerase
NXX00_RS07990	COG0235	Class ii aldolase
NXX00_RS07995	COG1454	alcohol dehydrogenase
NXX00_RS08025	COG0564	pseudouridine synthase activity
NXX00_RS08085	COG3537	Alpha-1,2-mannosidase
NXX00_RS08090	COG2205	protein histidine kinase activity
NXX00_RS08090	COG3292	Two component regulator propeller
NXX00_RS08090	COG0745	RESPONSE REGULATOR receiver
NXX00_RS08100	COG4771	TonB-dependent receptor
NXX00_RS08135	COG3119	arylsulfatase activity
NXX00_RS08150	COG3119	arylsulfatase activity
NXX00_RS08155	COG2204	response regulator
NXX00_RS08160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NXX00_RS08160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NXX00_RS08165	COG0612	Peptidase, M16
NXX00_RS08170	COG0534	Mate efflux family protein
NXX00_RS08175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NXX00_RS08175	COG2205	protein histidine kinase activity
NXX00_RS08200	COG0488	(ABC) transporter
NXX00_RS08210	COG0138	bifunctional purine biosynthesis protein purh
NXX00_RS08235	COG0772	Belongs to the SEDS family
NXX00_RS08245	COG1774	PSP1 C-terminal conserved region
NXX00_RS08250	COG0470	DNA polymerase III
NXX00_RS08255	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NXX00_RS08265	COG2193	ferroxidase activity
NXX00_RS08305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NXX00_RS08310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NXX00_RS08315	COG1160	GTP binding
NXX00_RS08325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NXX00_RS08330	COG1127	ABC transporter
NXX00_RS08335	COG0724	RNA recognition motif
NXX00_RS08340	COG0544	peptidyl-prolyl cis-trans isomerase activity
NXX00_RS08345	COG0740	serine-type endopeptidase activity
NXX00_RS08350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NXX00_RS08355	COG0514	ATP-dependent DNA helicase (RecQ)
NXX00_RS08360	COG0516	GMP reductase activity
NXX00_RS08360	COG0517	IMP dehydrogenase activity
NXX00_RS08365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NXX00_RS08375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NXX00_RS08390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NXX00_RS08405	COG4771	TonB-dependent receptor
NXX00_RS08425	COG3537	Alpha-1,2-mannosidase
NXX00_RS08460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NXX00_RS08470	COG3022	response to hydroperoxide
NXX00_RS08475	COG0110	maltose O-acetyltransferase activity
NXX00_RS08505	COG1187	pseudouridine synthase activity
NXX00_RS08510	COG0017	Asparaginyl-tRNA synthetase
NXX00_RS08520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NXX00_RS08525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NXX00_RS08530	COG0052	Belongs to the universal ribosomal protein uS2 family
NXX00_RS08535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NXX00_RS08550	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NXX00_RS08555	COG0179	Fumarylacetoacetate (FAA) hydrolase
NXX00_RS08560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NXX00_RS08575	COG0482	sulfurtransferase activity
NXX00_RS08585	COG1570	exodeoxyribonuclease VII activity
NXX00_RS08595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NXX00_RS08605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NXX00_RS08610	COG0489	protein tyrosine kinase activity
NXX00_RS08650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NXX00_RS08670	COG0714	Associated with various cellular activities
NXX00_RS08675	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NXX00_RS08680	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NXX00_RS08685	COG0039	L-malate dehydrogenase activity
NXX00_RS08715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NXX00_RS08720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NXX00_RS08725	COG0811	peptide transport
NXX00_RS08730	COG0848	biopolymer transport protein
NXX00_RS08745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NXX00_RS08750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NXX00_RS08755	COG0105	UTP biosynthetic process
NXX00_RS08760	COG0739	heme binding
NXX00_RS08775	COG0149	triose-phosphate isomerase activity
NXX00_RS08785	COG0302	gtp cyclohydrolase
NXX00_RS08790	COG0358	DNA primase activity
NXX00_RS08800	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NXX00_RS08805	COG0436	Aminotransferase
NXX00_RS08820	COG0514	ATP-dependent DNA helicase (RecQ)
NXX00_RS08825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NXX00_RS08825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NXX00_RS08840	COG0009	L-threonylcarbamoyladenylate synthase
NXX00_RS08850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NXX00_RS08855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NXX00_RS08860	COG2333	competence protein COMEC
NXX00_RS08860	COG0658	competence protein
NXX00_RS08865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NXX00_RS08875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NXX00_RS08885	COG4771	TonB-dependent receptor
NXX00_RS08890	COG0561	phosphatase activity
NXX00_RS08910	COG3292	Two component regulator propeller
NXX00_RS08910	COG2205	protein histidine kinase activity
NXX00_RS08910	COG0745	RESPONSE REGULATOR receiver
NXX00_RS08915	COG4771	TonB-dependent receptor
NXX00_RS08935	COG3537	Alpha-1,2-mannosidase
NXX00_RS08940	COG3537	Alpha-1,2-mannosidase
NXX00_RS08950	COG3537	Alpha-1,2-mannosidase
NXX00_RS08955	COG3279	Response regulator of the LytR AlgR family
NXX00_RS08960	COG3275	phosphorelay sensor kinase activity
NXX00_RS08965	COG1566	PFAM secretion protein HlyD family protein
NXX00_RS08975	COG0386	Belongs to the glutathione peroxidase family
NXX00_RS08980	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NXX00_RS08985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NXX00_RS09000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NXX00_RS09015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NXX00_RS09020	COG0742	ribosomal rna small subunit methyltransferase
NXX00_RS09035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NXX00_RS09040	COG4771	TonB-dependent receptor
NXX00_RS09075	COG3537	Alpha-1,2-mannosidase
NXX00_RS09080	COG3537	Alpha-1,2-mannosidase
NXX00_RS09100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NXX00_RS09105	COG0739	heme binding
NXX00_RS09115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NXX00_RS09120	COG0741	lytic transglycosylase activity
NXX00_RS09120	COG1388	LysM domain
NXX00_RS09135	COG1192	Involved in chromosome partitioning
NXX00_RS09140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NXX00_RS09145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NXX00_RS09155	COG4589	Belongs to the CDS family
NXX00_RS09160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NXX00_RS09165	COG0799	negative regulation of ribosome biogenesis
NXX00_RS09215	COG3023	N-Acetylmuramoyl-L-alanine amidase
NXX00_RS09265	COG4206	TonB-dependent receptor
NXX00_RS09265	COG1629	transport
NXX00_RS09280	COG1196	nuclear chromosome segregation
NXX00_RS09285	COG2239	Acts as a magnesium transporter
NXX00_RS09290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NXX00_RS09335	COG1119	ATPase activity
NXX00_RS09345	COG0668	transmembrane transport
NXX00_RS09350	COG2207	Transcriptional regulator
NXX00_RS09350	COG0662	Cupin 2, conserved barrel domain protein
NXX00_RS09375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NXX00_RS09380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NXX00_RS09385	COG0713	ATP synthesis coupled electron transport
NXX00_RS09405	COG0649	NAD binding
NXX00_RS09405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NXX00_RS09410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NXX00_RS09415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NXX00_RS09450	COG3250	beta-galactosidase activity
NXX00_RS09485	COG3408	Glycogen debranching enzyme
NXX00_RS09490	COG3119	arylsulfatase activity
NXX00_RS09495	COG3119	arylsulfatase activity
NXX00_RS09505	COG4771	TonB-dependent receptor
NXX00_RS09525	COG3119	arylsulfatase activity
NXX00_RS09535	COG0702	epimerase
NXX00_RS09550	COG4771	TonB-dependent receptor
NXX00_RS09555	COG0702	epimerase
NXX00_RS09560	COG1629	transport
NXX00_RS09560	COG4206	TonB-dependent receptor
NXX00_RS09570	COG3537	Alpha-1,2-mannosidase
NXX00_RS09595	COG0569	domain protein
NXX00_RS09600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NXX00_RS09610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NXX00_RS09615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NXX00_RS09620	COG0805	protein transport
NXX00_RS09630	COG2271	Major facilitator Superfamily
NXX00_RS09635	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NXX00_RS09640	COG3775	system Galactitol-specific IIC component
NXX00_RS09655	COG2755	lipolytic protein G-D-S-L family
NXX00_RS09660	COG3292	Two component regulator propeller
NXX00_RS09660	COG0745	RESPONSE REGULATOR receiver
NXX00_RS09660	COG2205	protein histidine kinase activity
NXX00_RS09670	COG0702	epimerase
NXX00_RS09675	COG4771	TonB-dependent receptor
NXX00_RS09695	COG3279	Response regulator of the LytR AlgR family
NXX00_RS09710	COG1629	transport
NXX00_RS09710	COG4206	TonB-dependent receptor
NXX00_RS09725	COG0745	RESPONSE REGULATOR receiver
NXX00_RS09725	COG2205	protein histidine kinase activity
NXX00_RS09725	COG3292	Two component regulator propeller
NXX00_RS09730	COG1242	4 iron, 4 sulfur cluster binding
NXX00_RS09740	COG0363	glucosamine-6-phosphate deaminase activity
NXX00_RS09745	COG0009	L-threonylcarbamoyladenylate synthase
NXX00_RS09755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NXX00_RS09770	COG1408	metallophosphoesterase
NXX00_RS09795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NXX00_RS09820	COG2755	lipolytic protein G-D-S-L family
NXX00_RS09850	COG3250	beta-galactosidase activity
NXX00_RS09855	COG3345	alpha-galactosidase
NXX00_RS09890	COG4771	TonB-dependent receptor
NXX00_RS09895	COG0702	epimerase
NXX00_RS09910	COG4771	TonB-dependent receptor
NXX00_RS09935	COG2755	lipolytic protein G-D-S-L family
NXX00_RS09945	COG3401	FG-GAP repeat protein
NXX00_RS09955	COG3254	rhamnose metabolic process
NXX00_RS09960	COG0745	RESPONSE REGULATOR receiver
NXX00_RS09960	COG2205	protein histidine kinase activity
NXX00_RS09960	COG3292	Two component regulator propeller
NXX00_RS09960	COG2205	protein histidine kinase activity
NXX00_RS09960	COG3292	Two component regulator propeller
NXX00_RS09960	COG0745	RESPONSE REGULATOR receiver
NXX00_RS09970	COG3250	beta-galactosidase activity
NXX00_RS09975	COG0745	RESPONSE REGULATOR receiver
NXX00_RS09975	COG2205	protein histidine kinase activity
NXX00_RS09975	COG3292	Two component regulator propeller
NXX00_RS09985	COG0546	phosphoglycolate phosphatase activity
NXX00_RS10005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NXX00_RS10015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NXX00_RS10025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NXX00_RS10030	COG0823	Involved in the tonB-independent uptake of proteins
NXX00_RS10030	COG1506	peptidase
NXX00_RS10075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NXX00_RS10090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NXX00_RS10090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NXX00_RS10095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NXX00_RS10100	COG1078	dGTPase activity
NXX00_RS10105	COG0284	orotidine-5'-phosphate decarboxylase activity
NXX00_RS10110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NXX00_RS10125	COG1704	LemA family
NXX00_RS10140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NXX00_RS10145	COG2226	methyltransferase
NXX00_RS10150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NXX00_RS10155	COG1702	phosphate starvation-inducible protein PhoH
NXX00_RS10165	COG2268	Band 7 protein
NXX00_RS10220	COG1349	DNA-binding transcription factor activity
NXX00_RS10270	COG0745	RESPONSE REGULATOR receiver
NXX00_RS10270	COG2205	protein histidine kinase activity
NXX00_RS10270	COG3292	Two component regulator propeller
NXX00_RS10275	COG0101	tRNA pseudouridine synthase activity
NXX00_RS10295	COG3250	beta-galactosidase activity
NXX00_RS10300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NXX00_RS10305	COG0673	inositol 2-dehydrogenase activity
NXX00_RS10325	COG4771	TonB-dependent receptor
NXX00_RS10345	COG5434	Belongs to the glycosyl hydrolase 28 family
NXX00_RS10350	COG0673	inositol 2-dehydrogenase activity
NXX00_RS10365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NXX00_RS10375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NXX00_RS10385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NXX00_RS10390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NXX00_RS10395	COG0793	Belongs to the peptidase S41A family
NXX00_RS10400	COG2131	deaminase
NXX00_RS10410	COG0339	signal peptide processing
NXX00_RS10420	COG1970	mechanosensitive ion channel activity
NXX00_RS10425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NXX00_RS10425	COG0519	Catalyzes the synthesis of GMP from XMP
NXX00_RS10515	COG4771	TonB-dependent receptor
NXX00_RS10605	COG4771	TonB-dependent receptor
NXX00_RS10635	COG0438	transferase activity, transferring glycosyl groups
NXX00_RS10650	COG0297	glycogen (starch) synthase activity
NXX00_RS10655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NXX00_RS10660	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NXX00_RS10665	COG0543	2 iron, 2 sulfur cluster binding
NXX00_RS10675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NXX00_RS10680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NXX00_RS10685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NXX00_RS10700	COG0791	NLP P60 protein
NXX00_RS10715	COG0612	Peptidase, M16
NXX00_RS10720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NXX00_RS10725	COG1597	lipid kinase activity
NXX00_RS10730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NXX00_RS10745	COG1136	(ABC) transporter
NXX00_RS10765	COG2211	Major facilitator Superfamily
NXX00_RS10770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NXX00_RS10785	COG1674	ftsk spoiiie
NXX00_RS10795	COG0492	ferredoxin-NADP+ reductase activity
NXX00_RS10800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS10840	COG1234	tRNA 3'-trailer cleavage
NXX00_RS10860	COG3956	TIGRFAM MazG family protein
NXX00_RS10875	COG0525	valine-tRNA ligase activity
NXX00_RS10880	COG0784	Response regulator, receiver
NXX00_RS10880	COG2205	protein histidine kinase activity
NXX00_RS10895	COG4206	TonB-dependent receptor
NXX00_RS10895	COG1629	transport
NXX00_RS10920	COG0653	protein targeting
NXX00_RS10925	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
NXX00_RS10935	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NXX00_RS10955	COG1253	flavin adenine dinucleotide binding
NXX00_RS10965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NXX00_RS10975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NXX00_RS10980	COG2204	response regulator
NXX00_RS11020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NXX00_RS11020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NXX00_RS11035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NXX00_RS11040	COG0563	adenylate kinase activity
NXX00_RS11045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NXX00_RS11050	COG1496	oxidoreductase activity
NXX00_RS11065	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS11070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS11080	COG2814	Major facilitator Superfamily
NXX00_RS11080	COG0477	Major facilitator Superfamily
NXX00_RS11085	COG0457	Tetratricopeptide repeat
NXX00_RS11090	COG2706	6-phosphogluconolactonase activity
NXX00_RS11115	COG1629	transport
NXX00_RS11115	COG4206	TonB-dependent receptor
NXX00_RS11180	COG3142	Participates in the control of copper homeostasis
NXX00_RS11185	COG1418	mRNA catabolic process
NXX00_RS11215	COG1070	Carbohydrate kinase
NXX00_RS11220	COG1063	alcohol dehydrogenase
NXX00_RS11225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NXX00_RS11250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NXX00_RS11250	COG1333	cytochrome c biogenesis protein
NXX00_RS11295	COG0673	inositol 2-dehydrogenase activity
NXX00_RS11305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NXX00_RS11310	COG2832	Protein of unknown function (DUF454)
NXX00_RS11320	COG0602	queuosine metabolic process
NXX00_RS11325	COG0247	lactate metabolic process
NXX00_RS11330	COG1139	Iron-sulfur cluster binding protein
NXX00_RS11340	COG0351	phosphomethylpyrimidine kinase
NXX00_RS11375	COG2304	oxidoreductase activity
NXX00_RS11390	COG1393	Belongs to the ArsC family
NXX00_RS11400	COG4206	TonB-dependent receptor
NXX00_RS11400	COG1629	transport
NXX00_RS11415	COG2233	PERMEase
NXX00_RS11420	COG1509	lysine 2,3-aminomutase activity
NXX00_RS11430	COG1115	amino acid carrier protein
NXX00_RS11470	COG1285	pathogenesis
NXX00_RS11480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NXX00_RS11485	COG0741	lytic transglycosylase activity
NXX00_RS11485	COG1388	LysM domain
NXX00_RS11545	COG0534	Mate efflux family protein
NXX00_RS11555	COG0564	pseudouridine synthase activity
NXX00_RS11580	COG0346	lactoylglutathione lyase activity
NXX00_RS11590	COG0653	protein targeting
NXX00_RS11620	COG1063	alcohol dehydrogenase
NXX00_RS11650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NXX00_RS11655	COG4804	nuclease activity
NXX00_RS11660	COG0732	type I restriction modification DNA specificity domain
NXX00_RS11740	COG4974	Belongs to the 'phage' integrase family
NXX00_RS11805	COG4974	Belongs to the 'phage' integrase family
NXX00_RS11815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NXX00_RS11820	COG5002	protein histidine kinase activity
NXX00_RS11820	COG0784	Response regulator, receiver
NXX00_RS11825	COG2910	NAD(P)H-binding
NXX00_RS11835	COG4864	UPF0365 protein
NXX00_RS11850	COG0037	tRNA processing
NXX00_RS11860	COG1477	protein flavinylation
NXX00_RS11865	COG1971	Probably functions as a manganese efflux pump
NXX00_RS11880	COG0463	Glycosyl transferase, family 2
NXX00_RS11895	COG3279	Response regulator of the LytR AlgR family
NXX00_RS11920	COG1595	DNA-templated transcription, initiation
NXX00_RS11925	COG0148	phosphopyruvate hydratase activity
NXX00_RS11935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NXX00_RS11950	COG1082	Xylose isomerase domain protein TIM barrel
NXX00_RS11960	COG2195	Cleaves the N-terminal amino acid of tripeptides
NXX00_RS11980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NXX00_RS11980	COG4651	solute:proton antiporter activity
NXX00_RS11990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NXX00_RS11995	COG0193	aminoacyl-tRNA hydrolase activity
NXX00_RS12000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NXX00_RS12010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NXX00_RS12015	COG1862	Preprotein translocase
NXX00_RS12025	COG0237	dephospho-CoA kinase activity
NXX00_RS12040	COG0542	response to heat
NXX00_RS12050	COG0583	DNA-binding transcription factor activity
NXX00_RS12065	COG2855	membrane
NXX00_RS12070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NXX00_RS12075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NXX00_RS12095	COG0443	Heat shock 70 kDa protein
NXX00_RS12165	COG1111	helicase
NXX00_RS12165	COG1205	dead DEAH box helicase
NXX00_RS12165	COG1205	dead DEAH box helicase
NXX00_RS12165	COG1111	helicase
NXX00_RS12170	COG3177	Filamentation induced by cAMP protein fic
NXX00_RS12190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NXX00_RS12195	COG0306	phosphate transporter
NXX00_RS12205	COG0586	Pfam SNARE associated Golgi protein
NXX00_RS12255	COG0038	chloride channel
NXX00_RS12260	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NXX00_RS12285	COG3119	arylsulfatase activity
NXX00_RS12295	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NXX00_RS12300	COG0702	epimerase
NXX00_RS12305	COG4771	TonB-dependent receptor
NXX00_RS12315	COG5434	Belongs to the glycosyl hydrolase 28 family
NXX00_RS12320	COG3292	Two component regulator propeller
NXX00_RS12320	COG2205	protein histidine kinase activity
NXX00_RS12320	COG0745	RESPONSE REGULATOR receiver
NXX00_RS12325	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
NXX00_RS12330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NXX00_RS12350	COG1404	Belongs to the peptidase S8 family
NXX00_RS12350	COG4935	Belongs to the peptidase S8 family
NXX00_RS12405	COG0156	8-amino-7-oxononanoate synthase activity
NXX00_RS12415	COG3250	beta-galactosidase activity
NXX00_RS12430	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NXX00_RS12435	COG1629	transport
NXX00_RS12435	COG4206	TonB-dependent receptor
NXX00_RS12445	COG5002	protein histidine kinase activity
NXX00_RS12475	COG0598	Magnesium transport protein CorA
NXX00_RS12480	COG1193	negative regulation of DNA recombination
NXX00_RS12490	COG4974	Belongs to the 'phage' integrase family
NXX00_RS12570	COG3344	reverse transcriptase
NXX00_RS12650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NXX00_RS12650	COG0551	DNA topoisomerase type I activity
NXX00_RS12655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NXX00_RS12655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NXX00_RS12755	COG4974	Belongs to the 'phage' integrase family
NXX00_RS12760	COG1309	transcriptional regulator
NXX00_RS12825	COG4771	TonB-dependent receptor
NXX00_RS12845	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS12860	COG3250	beta-galactosidase activity
NXX00_RS12870	COG4771	TonB-dependent receptor
NXX00_RS12885	COG0668	transmembrane transport
NXX00_RS12890	COG1523	belongs to the glycosyl hydrolase 13 family
NXX00_RS12900	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NXX00_RS12910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NXX00_RS12920	COG1538	Outer membrane efflux protein
NXX00_RS12930	COG0456	acetyltransferase
NXX00_RS12940	COG3189	MarR family transcriptional regulator
NXX00_RS12945	COG0561	phosphatase activity
NXX00_RS12950	COG1169	isochorismate synthase
NXX00_RS12955	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NXX00_RS12960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NXX00_RS12965	COG4948	Mandelate Racemase Muconate Lactonizing
NXX00_RS12970	COG0318	PFAM AMP-dependent synthetase and ligase
NXX00_RS12985	COG4206	TonB-dependent receptor
NXX00_RS12985	COG1629	transport
NXX00_RS13025	COG0783	Belongs to the Dps family
NXX00_RS13030	COG0583	DNA-binding transcription factor activity
NXX00_RS13040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NXX00_RS13045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NXX00_RS13190	COG2801	Transposase and inactivated derivatives
NXX00_RS13225	COG1192	Involved in chromosome partitioning
NXX00_RS13235	COG2226	methyltransferase
NXX00_RS13245	COG0534	Mate efflux family protein
NXX00_RS13250	COG0189	ligase activity
NXX00_RS13250	COG2918	glutathione biosynthetic process
NXX00_RS13255	COG1045	serine acetyltransferase
NXX00_RS13265	COG2801	Transposase and inactivated derivatives
NXX00_RS13285	COG2003	Belongs to the UPF0758 family
NXX00_RS13290	COG1475	DNA binding
NXX00_RS13325	COG1192	Involved in chromosome partitioning
NXX00_RS13350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NXX00_RS13435	COG0419	ATPase involved in DNA repair
NXX00_RS13475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NXX00_RS13480	COG0741	lytic transglycosylase activity
NXX00_RS13480	COG1196	nuclear chromosome segregation
NXX00_RS13480	COG0739	heme binding
NXX00_RS13545	COG1705	Flagellar rod assembly protein muramidase FlgJ
NXX00_RS13565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NXX00_RS13710	COG4771	TonB-dependent receptor
NXX00_RS13715	COG0702	epimerase
NXX00_RS13790	COG3023	N-Acetylmuramoyl-L-alanine amidase
NXX00_RS13795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NXX00_RS13810	COG4974	Belongs to the 'phage' integrase family
NXX00_RS13960	COG0551	DNA topoisomerase type I activity
NXX00_RS13960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NXX00_RS14020	COG4974	Belongs to the 'phage' integrase family
NXX00_RS14035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NXX00_RS14070	COG0745	RESPONSE REGULATOR receiver
NXX00_RS14070	COG2205	protein histidine kinase activity
NXX00_RS14070	COG3292	Two component regulator propeller
NXX00_RS14080	COG1595	DNA-templated transcription, initiation
NXX00_RS14085	COG1629	transport
NXX00_RS14090	COG0561	phosphatase activity
NXX00_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
NXX00_RS14130	COG4948	Mandelate Racemase Muconate Lactonizing
NXX00_RS14135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NXX00_RS14155	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NXX00_RS14165	COG1253	flavin adenine dinucleotide binding
NXX00_RS14170	COG0501	Belongs to the peptidase M48B family
NXX00_RS14195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NXX00_RS14205	COG2197	response regulator
NXX00_RS14215	COG1757	Na H antiporter
NXX00_RS14230	COG2814	Major facilitator Superfamily
NXX00_RS14235	COG4953	penicillin-binding protein 1C
NXX00_RS14240	COG2373	Large extracellular alpha-helical protein
NXX00_RS14245	COG0545	Peptidyl-prolyl cis-trans isomerase
NXX00_RS14320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NXX00_RS14325	COG0646	methionine synthase
NXX00_RS14325	COG1410	methionine synthase
NXX00_RS14330	COG0778	Nitroreductase
NXX00_RS14335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NXX00_RS14345	COG0572	uridine kinase
NXX00_RS14355	COG4232	protein-disulfide reductase activity
NXX00_RS14360	COG1741	Belongs to the pirin family
NXX00_RS14375	COG1629	transport
NXX00_RS14380	COG0702	epimerase
NXX00_RS14425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NXX00_RS14430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NXX00_RS14435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NXX00_RS14440	COG0131	Imidazoleglycerol-phosphate dehydratase
NXX00_RS14450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NXX00_RS14450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NXX00_RS14455	COG4771	TonB-dependent receptor
NXX00_RS14485	COG1404	Belongs to the peptidase S8 family
NXX00_RS14505	COG1592	Rubrerythrin
NXX00_RS14505	COG1773	rubredoxin
NXX00_RS14535	COG3591	Belongs to the peptidase S1B family
NXX00_RS14540	COG3591	Belongs to the peptidase S1B family
NXX00_RS14545	COG0641	radical SAM
NXX00_RS14575	COG0420	3'-5' exonuclease activity
NXX00_RS14585	COG1408	metallophosphoesterase
NXX00_RS14600	COG1410	methionine synthase
NXX00_RS14600	COG0646	methionine synthase
NXX00_RS14605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NXX00_RS14610	COG0463	Glycosyl transferase, family 2
NXX00_RS14615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NXX00_RS14625	COG1032	radical SAM domain protein
NXX00_RS14645	COG0363	glucosamine-6-phosphate deaminase activity
NXX00_RS14650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NXX00_RS14685	COG0745	RESPONSE REGULATOR receiver
NXX00_RS14685	COG2205	protein histidine kinase activity
NXX00_RS14685	COG3292	Two component regulator propeller
NXX00_RS14690	COG1629	transport
NXX00_RS14695	COG0702	epimerase
NXX00_RS14710	COG4771	TonB-dependent receptor
NXX00_RS14765	COG0811	peptide transport
NXX00_RS14770	COG0848	biopolymer transport protein
NXX00_RS14835	COG1131	(ABC) transporter
NXX00_RS14870	COG1752	Esterase of the alpha-beta hydrolase superfamily
NXX00_RS14910	COG0508	dehydrogenase complex catalyzes the overall conversion of
NXX00_RS14915	COG0022	dehydrogenase e1 component
NXX00_RS14925	COG2264	protein methyltransferase activity
NXX00_RS14940	COG4206	TonB-dependent receptor
NXX00_RS14940	COG1629	transport
NXX00_RS14955	COG0590	tRNA wobble adenosine to inosine editing
NXX00_RS14960	COG0673	inositol 2-dehydrogenase activity
NXX00_RS14985	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NXX00_RS15025	COG0714	Associated with various cellular activities
NXX00_RS15030	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NXX00_RS15045	COG1501	Belongs to the glycosyl hydrolase 31 family
NXX00_RS15050	COG5012	cobalamin binding
NXX00_RS15080	COG0698	ribose 5-phosphate isomerase
NXX00_RS15085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NXX00_RS15100	COG1070	Carbohydrate kinase
NXX00_RS15105	COG2160	L-arabinose isomerase activity
NXX00_RS15140	COG0702	epimerase
NXX00_RS15145	COG1629	transport
NXX00_RS15145	COG4206	TonB-dependent receptor
NXX00_RS15150	COG0702	epimerase
NXX00_RS15160	COG4206	TonB-dependent receptor
NXX00_RS15160	COG1629	transport
NXX00_RS15170	COG2205	protein histidine kinase activity
NXX00_RS15170	COG0745	RESPONSE REGULATOR receiver
NXX00_RS15170	COG3292	Two component regulator propeller
NXX00_RS15175	COG3507	Belongs to the glycosyl hydrolase 43 family
NXX00_RS15185	COG3507	Belongs to the glycosyl hydrolase 43 family
NXX00_RS15190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NXX00_RS15205	COG1482	cell wall glycoprotein biosynthetic process
NXX00_RS15235	COG1086	Polysaccharide biosynthesis protein
NXX00_RS15240	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NXX00_RS15250	COG2089	acid synthase
NXX00_RS15285	COG1216	Glycosyl transferase, family 2
NXX00_RS15295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NXX00_RS15325	COG3023	N-Acetylmuramoyl-L-alanine amidase
NXX00_RS15365	COG4221	oxidoreductase activity
NXX00_RS15375	COG1218	3'(2'),5'-bisphosphate nucleotidase
NXX00_RS15380	COG3273	potassium ion transport
NXX00_RS15380	COG0471	metal ion transport
NXX00_RS15385	COG0529	Catalyzes the synthesis of activated sulfate
NXX00_RS15390	COG0175	sulfate reduction
NXX00_RS15395	COG2895	sulfate adenylyltransferase (ATP) activity
NXX00_RS15415	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NXX00_RS15420	COG0242	peptide deformylase activity
NXX00_RS15430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NXX00_RS15435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NXX00_RS15440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NXX00_RS15445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NXX00_RS15455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NXX00_RS15460	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NXX00_RS15465	COG0674	pyruvate-flavodoxin oxidoreductase activity
NXX00_RS15465	COG1013	pyruvate-flavodoxin oxidoreductase activity
NXX00_RS15465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NXX00_RS15465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NXX00_RS15475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NXX00_RS15490	COG1940	carbohydrate kinase activity
NXX00_RS15495	COG2081	HI0933 family
NXX00_RS15515	COG4771	TonB-dependent receptor
NXX00_RS15550	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NXX00_RS15550	COG2755	lipolytic protein G-D-S-L family
NXX00_RS15580	COG4771	TonB-dependent receptor
NXX00_RS15655	COG1629	transport
NXX00_RS15680	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS15685	COG0657	acetylesterase activity
NXX00_RS15685	COG2755	lipolytic protein G-D-S-L family
NXX00_RS15695	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS15700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS15705	COG3250	beta-galactosidase activity
NXX00_RS15725	COG1091	dTDP-4-dehydrorhamnose reductase activity
NXX00_RS15780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NXX00_RS15790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NXX00_RS15815	COG0489	protein tyrosine kinase activity
NXX00_RS15815	COG3206	protein involved in exopolysaccharide biosynthesis
NXX00_RS15820	COG4771	TonB-dependent receptor
NXX00_RS15825	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NXX00_RS15830	COG0484	heat shock protein binding
NXX00_RS15835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NXX00_RS15840	COG0488	(ABC) transporter
NXX00_RS15855	COG2183	response to ionizing radiation
NXX00_RS15860	COG2205	protein histidine kinase activity
NXX00_RS15860	COG2202	Pas domain
NXX00_RS15865	COG0737	Belongs to the 5'-nucleotidase family
NXX00_RS15910	COG0490	domain, Protein
NXX00_RS15910	COG2985	domain, Protein
NXX00_RS15915	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NXX00_RS15930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NXX00_RS15935	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NXX00_RS15945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NXX00_RS15955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NXX00_RS15965	COG2837	iron assimilation
NXX00_RS15970	COG2135	peptidase activity
NXX00_RS15975	COG3279	Response regulator of the LytR AlgR family
NXX00_RS15985	COG0577	efflux transmembrane transporter activity
NXX00_RS15985	COG1136	(ABC) transporter
NXX00_RS15990	COG1136	(ABC) transporter
NXX00_RS16020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NXX00_RS16030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NXX00_RS16055	COG0501	Belongs to the peptidase M48B family
NXX00_RS16060	COG1704	LemA family
NXX00_RS16080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NXX00_RS16085	COG2885	chlorophyll binding
NXX00_RS16090	COG0534	Mate efflux family protein
NXX00_RS16095	COG0657	acetylesterase activity
NXX00_RS16095	COG2755	lipolytic protein G-D-S-L family
NXX00_RS16105	COG1162	GTPase activity
NXX00_RS16125	COG0488	(ABC) transporter
NXX00_RS16155	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS16165	COG1442	glycosyl transferase family 8
NXX00_RS16175	COG2244	polysaccharide biosynthetic process
NXX00_RS16180	COG1442	glycosyl transferase family 8
NXX00_RS16180	COG1216	Glycosyl transferase, family 2
NXX00_RS16220	COG3023	N-Acetylmuramoyl-L-alanine amidase
NXX00_RS16230	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS16265	COG1805	sodium ion transport
NXX00_RS16270	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NXX00_RS16285	COG2871	sodium ion transport
NXX00_RS16290	COG0513	Belongs to the DEAD box helicase family
NXX00_RS16295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NXX00_RS16310	COG1739	Uncharacterized protein family UPF0029
NXX00_RS16325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NXX00_RS16325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NXX00_RS16330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NXX00_RS16335	COG0357	Ribosomal RNA small subunit methyltransferase G
NXX00_RS16380	COG2217	Heavy metal translocating P-type atpase
NXX00_RS16390	COG0321	lipoyl(octanoyl) transferase activity
NXX00_RS16420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NXX00_RS16430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NXX00_RS16445	COG1678	Uncharacterized ACR, COG1678
NXX00_RS16465	COG3275	phosphorelay sensor kinase activity
NXX00_RS16495	COG3969	phosphoadenosine phosphosulfate
NXX00_RS16500	COG1475	DNA binding
NXX00_RS16565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NXX00_RS16585	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS16610	COG4206	TonB-dependent receptor
NXX00_RS16610	COG1629	transport
NXX00_RS16640	COG4771	TonB-dependent receptor
NXX00_RS16685	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
NXX00_RS16690	COG3537	Alpha-1,2-mannosidase
NXX00_RS16705	COG1629	transport
NXX00_RS16710	COG0702	epimerase
NXX00_RS16720	COG1629	transport
NXX00_RS16720	COG4206	TonB-dependent receptor
NXX00_RS16750	COG3408	Glycogen debranching enzyme
NXX00_RS16785	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NXX00_RS16800	COG2755	lipolytic protein G-D-S-L family
NXX00_RS16800	COG0657	acetylesterase activity
NXX00_RS16850	COG5002	protein histidine kinase activity
NXX00_RS16850	COG2205	protein histidine kinase activity
NXX00_RS16850	COG0784	Response regulator, receiver
NXX00_RS16860	COG3250	beta-galactosidase activity
NXX00_RS16870	COG2205	protein histidine kinase activity
NXX00_RS16870	COG0784	Response regulator, receiver
NXX00_RS16895	COG0745	RESPONSE REGULATOR receiver
NXX00_RS16900	COG5002	protein histidine kinase activity
NXX00_RS16930	COG3250	beta-galactosidase activity
NXX00_RS16935	COG0745	RESPONSE REGULATOR receiver
NXX00_RS16935	COG2205	protein histidine kinase activity
NXX00_RS16935	COG3292	Two component regulator propeller
NXX00_RS16965	COG2966	Psort location CytoplasmicMembrane, score
NXX00_RS16980	COG0300	oxidoreductase activity
NXX00_RS16990	COG1011	Hydrolase
NXX00_RS17010	COG1595	DNA-templated transcription, initiation
NXX00_RS17040	COG4206	TonB-dependent receptor
NXX00_RS17050	COG3292	Two component regulator propeller
NXX00_RS17050	COG2205	protein histidine kinase activity
NXX00_RS17050	COG0745	RESPONSE REGULATOR receiver
NXX00_RS17065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NXX00_RS17080	COG0442	prolyl-tRNA aminoacylation
NXX00_RS17085	COG0745	RESPONSE REGULATOR receiver
NXX00_RS17090	COG2205	protein histidine kinase activity
NXX00_RS17125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NXX00_RS17135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NXX00_RS17140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NXX00_RS17150	COG0552	protein localization to endoplasmic reticulum
NXX00_RS17155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NXX00_RS17160	COG0776	regulation of translation
NXX00_RS17165	COG0776	regulation of translation
NXX00_RS17170	COG0714	Associated with various cellular activities
NXX00_RS17185	COG2304	oxidoreductase activity
NXX00_RS17235	COG0326	Molecular chaperone. Has ATPase activity
NXX00_RS17260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NXX00_RS17265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NXX00_RS17270	COG0336	Belongs to the RNA methyltransferase TrmD family
NXX00_RS17275	COG0167	dihydroorotate dehydrogenase activity
NXX00_RS17280	COG0543	2 iron, 2 sulfur cluster binding
NXX00_RS17295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NXX00_RS17325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NXX00_RS17345	COG1132	(ABC) transporter
NXX00_RS17375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NXX00_RS17380	COG1597	lipid kinase activity
NXX00_RS17385	COG0156	8-amino-7-oxononanoate synthase activity
NXX00_RS17400	COG4771	TonB-dependent receptor
NXX00_RS17420	COG0577	efflux transmembrane transporter activity
NXX00_RS17420	COG1136	(ABC) transporter
NXX00_RS17435	COG1136	(ABC) transporter
NXX00_RS17455	COG3852	Histidine kinase
NXX00_RS17465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NXX00_RS17485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NXX00_RS17490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NXX00_RS17510	COG0560	Phosphoserine phosphatase
NXX00_RS17510	COG3830	Belongs to the UPF0237 family
NXX00_RS17515	COG0513	Belongs to the DEAD box helicase family
NXX00_RS17545	COG0246	Mannitol dehydrogenase
NXX00_RS17550	COG1609	Transcriptional regulator
NXX00_RS17555	COG1904	glucuronate isomerase
NXX00_RS17575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NXX00_RS17600	COG3015	lipoprotein NlpE involved in copper resistance
NXX00_RS17630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NXX00_RS17655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NXX00_RS17665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NXX00_RS17665	COG3153	acetyltransferase
NXX00_RS17670	COG0477	Major facilitator Superfamily
NXX00_RS17670	COG2814	Major facilitator Superfamily
NXX00_RS17675	COG2115	Belongs to the xylose isomerase family
NXX00_RS17690	COG0351	phosphomethylpyrimidine kinase
NXX00_RS17695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NXX00_RS17700	COG0045	succinate-CoA ligase (ADP-forming) activity
NXX00_RS17705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NXX00_RS17735	COG3279	Response regulator of the LytR AlgR family
NXX00_RS17770	COG2326	polyphosphate kinase activity
NXX00_RS17780	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
NXX00_RS17805	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NXX00_RS17820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NXX00_RS17890	COG3292	Two component regulator propeller
NXX00_RS17890	COG2205	protein histidine kinase activity
NXX00_RS17890	COG0745	RESPONSE REGULATOR receiver
NXX00_RS17905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NXX00_RS17910	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NXX00_RS17915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NXX00_RS17925	COG1214	PFAM Peptidase M22, glycoprotease
NXX00_RS17925	COG0456	acetyltransferase
NXX00_RS17930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NXX00_RS17940	COG0110	maltose O-acetyltransferase activity
NXX00_RS17955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NXX00_RS17975	COG0438	transferase activity, transferring glycosyl groups
NXX00_RS17980	COG0438	transferase activity, transferring glycosyl groups
NXX00_RS18000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NXX00_RS18030	COG3153	acetyltransferase
NXX00_RS18035	COG3250	beta-galactosidase activity
NXX00_RS18040	COG3119	arylsulfatase activity
NXX00_RS18050	COG4206	TonB-dependent receptor
NXX00_RS18050	COG1629	transport
NXX00_RS18080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NXX00_RS18095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NXX00_RS18110	COG0540	Belongs to the ATCase OTCase family
NXX00_RS18115	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NXX00_RS18130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NXX00_RS18135	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NXX00_RS18140	COG2985	domain, Protein
NXX00_RS18180	COG2207	Transcriptional regulator
NXX00_RS18205	COG2431	L-lysine efflux transmembrane transporter activity
NXX00_RS18210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NXX00_RS18220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NXX00_RS18225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NXX00_RS18230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NXX00_RS18235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NXX00_RS18240	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NXX00_RS18245	COG0356	it plays a direct role in the translocation of protons across the membrane
NXX00_RS18255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NXX00_RS18260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NXX00_RS18285	COG3023	N-Acetylmuramoyl-L-alanine amidase
NXX00_RS18300	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NXX00_RS18320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NXX00_RS18330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NXX00_RS18340	COG0534	Mate efflux family protein
NXX00_RS18350	COG1136	(ABC) transporter
NXX00_RS18385	COG1151	hydroxylamine reductase activity
NXX00_RS18390	COG2233	PERMEase
NXX00_RS18395	COG3263	regulation of cellular component size
NXX00_RS18400	COG0318	PFAM AMP-dependent synthetase and ligase
NXX00_RS18405	COG1082	Xylose isomerase domain protein TIM barrel
NXX00_RS18410	COG0745	RESPONSE REGULATOR receiver
NXX00_RS18415	COG5002	protein histidine kinase activity
NXX00_RS18435	COG3118	belongs to the thioredoxin family
NXX00_RS18440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NXX00_RS18485	COG2249	NAD(P)H dehydrogenase (quinone) activity
NXX00_RS18505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NXX00_RS18535	COG0681	Belongs to the peptidase S26 family
NXX00_RS18625	COG0210	DNA helicase
NXX00_RS18640	COG5002	protein histidine kinase activity
NXX00_RS18650	COG0352	thiamine-phosphate diphosphorylase activity
NXX00_RS18655	COG2022	thiamine diphosphate biosynthetic process
NXX00_RS18660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NXX00_RS18665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NXX00_RS18670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NXX00_RS18675	COG0352	thiamine-phosphate diphosphorylase activity
NXX00_RS18740	COG0574	Belongs to the PEP-utilizing enzyme family
NXX00_RS18740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NXX00_RS18745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NXX00_RS18750	COG0564	pseudouridine synthase activity
NXX00_RS18775	COG0024	Methionine aminopeptidase
NXX00_RS18795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NXX00_RS18805	COG0481	GTPase activity
NXX00_RS18820	COG0708	Exodeoxyribonuclease III
NXX00_RS18835	COG0217	transcriptional regulatory protein
NXX00_RS18840	COG0072	phenylalanine-tRNA ligase activity
NXX00_RS18840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NXX00_RS18845	COG0305	Participates in initiation and elongation during chromosome replication
NXX00_RS18850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NXX00_RS18855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NXX00_RS18860	COG4657	Part of a membrane complex involved in electron transport
NXX00_RS18865	COG4660	Part of a membrane complex involved in electron transport
NXX00_RS18870	COG4659	FMN binding
NXX00_RS18875	COG4658	electron transport chain
NXX00_RS18880	COG4656	Part of a membrane complex involved in electron transport
NXX00_RS18925	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS18980	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS18985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NXX00_RS18995	COG1086	Polysaccharide biosynthesis protein
NXX00_RS19050	COG0504	CTP synthase activity
NXX00_RS19055	COG0706	membrane insertase activity
NXX00_RS19060	COG0534	Mate efflux family protein
NXX00_RS19065	COG0823	Involved in the tonB-independent uptake of proteins
NXX00_RS19065	COG1506	peptidase
NXX00_RS19085	COG1983	PspC domain protein
NXX00_RS19090	COG1695	Transcriptional regulator
NXX00_RS19100	COG3104	oligopeptide transport
NXX00_RS19105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NXX00_RS19115	COG1388	LysM domain
NXX00_RS19115	COG3942	CHAP domain
NXX00_RS19145	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NXX00_RS19150	COG0556	nucleotide-excision repair
NXX00_RS19165	COG2949	membrane
NXX00_RS19170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NXX00_RS19180	COG0842	Transport permease protein
NXX00_RS19185	COG0842	Transport permease protein
NXX00_RS19190	COG1131	(ABC) transporter
NXX00_RS19205	COG2207	Transcriptional regulator
NXX00_RS19205	COG1917	Cupin 2, conserved barrel domain protein
NXX00_RS19215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NXX00_RS19220	COG0505	Belongs to the CarA family
NXX00_RS19230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NXX00_RS19235	COG0067	glutamate synthase
NXX00_RS19235	COG0070	glutamate synthase
NXX00_RS19235	COG0069	glutamate synthase activity
NXX00_RS19245	COG0367	asparagine synthase
NXX00_RS19260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NXX00_RS19265	COG0436	Aminotransferase
NXX00_RS19275	COG0347	Belongs to the P(II) protein family
NXX00_RS19280	COG0004	ammonium transporteR
NXX00_RS19295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NXX00_RS19310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NXX00_RS19315	COG0490	domain, Protein
NXX00_RS19315	COG0471	metal ion transport
NXX00_RS19330	COG1979	alcohol dehydrogenase
NXX00_RS19340	COG0133	tryptophan synthase activity
NXX00_RS19345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NXX00_RS19355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NXX00_RS19360	COG0134	indole-3-glycerol-phosphate synthase activity
NXX00_RS19365	COG0135	phosphoribosylanthranilate isomerase activity
NXX00_RS19370	COG0159	tryptophan synthase activity
NXX00_RS19375	COG0252	asparaginase activity
NXX00_RS19385	COG3292	Two component regulator propeller
NXX00_RS19385	COG0745	RESPONSE REGULATOR receiver
NXX00_RS19385	COG2205	protein histidine kinase activity
NXX00_RS19390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NXX00_RS19400	COG0110	maltose O-acetyltransferase activity
NXX00_RS19405	COG2197	response regulator
NXX00_RS19415	COG0138	bifunctional purine biosynthesis protein purh
NXX00_RS19420	COG0716	FMN binding
NXX00_RS19470	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS19480	COG4771	TonB-dependent receptor
NXX00_RS19490	COG4771	TonB-dependent receptor
NXX00_RS19500	COG0490	domain, Protein
NXX00_RS19500	COG2985	domain, Protein
NXX00_RS19505	COG1230	cation diffusion facilitator family transporter
NXX00_RS19525	COG1609	Transcriptional regulator
NXX00_RS19530	COG2721	sulfolactate sulfo-lyase activity
NXX00_RS19610	COG1733	regulation of RNA biosynthetic process
NXX00_RS19620	COG2205	protein histidine kinase activity
NXX00_RS19620	COG2198	Histidine kinase
NXX00_RS19620	COG0784	Response regulator, receiver
NXX00_RS19620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NXX00_RS19630	COG3275	phosphorelay sensor kinase activity
NXX00_RS19655	COG0228	four-way junction DNA binding
NXX00_RS19660	COG2188	Transcriptional regulator
NXX00_RS19665	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
NXX00_RS19675	COG1070	Carbohydrate kinase
NXX00_RS19685	COG0738	Major facilitator superfamily
NXX00_RS19750	COG1177	transmembrane transport
NXX00_RS19755	COG1176	ABC-type spermidine putrescine transport system, permease component I
NXX00_RS19760	COG3842	ATPase activity
NXX00_RS19765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NXX00_RS19770	COG0058	SHG alpha-glucan phosphorylase activity
NXX00_RS19780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NXX00_RS19800	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
NXX00_RS19825	COG1725	Transcriptional regulator
NXX00_RS19835	COG1131	(ABC) transporter
NXX00_RS19880	COG4974	Belongs to the 'phage' integrase family
NXX00_RS19930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NXX00_RS19935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS19945	COG4771	TonB-dependent receptor
NXX00_RS20075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NXX00_RS20080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NXX00_RS20085	COG4948	Mandelate Racemase Muconate Lactonizing
NXX00_RS20115	COG0704	Plays a role in the regulation of phosphate uptake
NXX00_RS20120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NXX00_RS20125	COG0581	inorganic phosphate transmembrane transporter activity
NXX00_RS20130	COG0573	inorganic phosphate transmembrane transporter activity
NXX00_RS20140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NXX00_RS20150	COG0586	Pfam SNARE associated Golgi protein
NXX00_RS20160	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NXX00_RS20175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NXX00_RS20180	COG0167	dihydroorotate dehydrogenase activity
NXX00_RS20185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NXX00_RS20230	COG1442	glycosyl transferase family 8
NXX00_RS20230	COG1216	Glycosyl transferase, family 2
NXX00_RS20240	COG5039	Polysaccharide pyruvyl transferase
NXX00_RS20290	COG0497	DNA recombination
NXX00_RS20305	COG0592	DNA-directed DNA polymerase activity
NXX00_RS20320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NXX00_RS20320	COG0321	lipoyl(octanoyl) transferase activity
NXX00_RS20325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NXX00_RS20335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NXX00_RS20340	COG0156	8-amino-7-oxononanoate synthase activity
NXX00_RS20355	COG0019	diaminopimelate decarboxylase activity
NXX00_RS20360	COG0527	aspartate kinase activity
NXX00_RS20365	COG2884	Cell division ATP-binding protein ftsE
NXX00_RS20370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NXX00_RS20370	COG0140	phosphoribosyl-ATP diphosphatase activity
NXX00_RS20375	COG0107	imidazoleglycerol-phosphate synthase activity
NXX00_RS20380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NXX00_RS20385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NXX00_RS20390	COG0788	formyltetrahydrofolate deformylase activity
NXX00_RS20405	COG0693	protein deglycase activity
NXX00_RS20410	COG0656	L-ascorbic acid biosynthetic process
NXX00_RS20430	COG0534	Mate efflux family protein
NXX00_RS20435	COG2076	Multidrug Resistance protein
NXX00_RS20450	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NXX00_RS20450	COG2885	chlorophyll binding
NXX00_RS20480	COG3546	catalase activity
NXX00_RS20515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NXX00_RS20565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NXX00_RS20570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NXX00_RS20585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NXX00_RS20595	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NXX00_RS20610	COG4771	TonB-dependent receptor
NXX00_RS20710	COG1312	Catalyzes the dehydration of D-mannonate
NXX00_RS20715	COG1028	Short-chain dehydrogenase reductase Sdr
NXX00_RS20720	COG1609	Transcriptional regulator
NXX00_RS20735	COG1929	Belongs to the glycerate kinase type-1 family
NXX00_RS20740	COG2223	nitrite transmembrane transporter activity
NXX00_RS20750	COG4771	TonB-dependent receptor
NXX00_RS20760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NXX00_RS20760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NXX00_RS20775	COG2226	methyltransferase
NXX00_RS20785	COG5002	protein histidine kinase activity
NXX00_RS20785	COG0784	Response regulator, receiver
NXX00_RS20790	COG0511	ligase activity, forming carbon-carbon bonds
NXX00_RS20795	COG0439	Biotin carboxylase
NXX00_RS20800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NXX00_RS20815	COG1620	l-lactate permease
NXX00_RS20820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NXX00_RS20825	COG1690	Belongs to the RtcB family
NXX00_RS20865	COG0110	maltose O-acetyltransferase activity
NXX00_RS20875	COG0577	efflux transmembrane transporter activity
NXX00_RS20880	COG0577	efflux transmembrane transporter activity
NXX00_RS20880	COG1136	(ABC) transporter
NXX00_RS20895	COG2204	response regulator
NXX00_RS20910	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS20920	COG0189	ligase activity
NXX00_RS20920	COG0569	domain protein
NXX00_RS20925	COG0577	efflux transmembrane transporter activity
NXX00_RS20925	COG1136	(ABC) transporter
NXX00_RS20930	COG0436	Aminotransferase
NXX00_RS20945	COG0488	(ABC) transporter
NXX00_RS20960	COG0745	RESPONSE REGULATOR receiver
NXX00_RS20965	COG5002	protein histidine kinase activity
NXX00_RS21020	COG3033	Beta-eliminating lyase
NXX00_RS21045	COG0629	single-stranded DNA binding
NXX00_RS21050	COG1194	a g-specific adenine glycosylase
NXX00_RS21060	COG1530	ribonuclease E activity
NXX00_RS21065	COG2885	chlorophyll binding
NXX00_RS21080	COG2885	chlorophyll binding
NXX00_RS21110	COG0305	Participates in initiation and elongation during chromosome replication
NXX00_RS21125	COG3023	N-Acetylmuramoyl-L-alanine amidase
NXX00_RS21145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NXX00_RS21155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NXX00_RS21170	COG4191	Histidine kinase
NXX00_RS21175	COG2204	response regulator
NXX00_RS21185	COG5002	protein histidine kinase activity
NXX00_RS21185	COG2205	protein histidine kinase activity
NXX00_RS21185	COG0784	Response regulator, receiver
NXX00_RS21205	COG1136	(ABC) transporter
NXX00_RS21215	COG1252	NADH dehydrogenase
NXX00_RS21220	COG1705	Flagellar rod assembly protein muramidase FlgJ
NXX00_RS21235	COG3059	membrane
NXX00_RS21240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NXX00_RS21245	COG3292	Two component regulator propeller
NXX00_RS21245	COG2205	protein histidine kinase activity
NXX00_RS21245	COG0745	RESPONSE REGULATOR receiver
NXX00_RS21260	COG0488	(ABC) transporter
NXX00_RS21285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NXX00_RS21295	COG0739	heme binding
NXX00_RS21300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NXX00_RS21305	COG1629	transport
NXX00_RS21315	COG0686	Belongs to the AlaDH PNT family
NXX00_RS21360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NXX00_RS21370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NXX00_RS21380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NXX00_RS21410	COG1595	DNA-templated transcription, initiation
NXX00_RS21425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NXX00_RS21430	COG1741	Belongs to the pirin family
NXX00_RS21435	COG0259	pyridoxamine-phosphate oxidase activity
NXX00_RS21500	COG0456	acetyltransferase
NXX00_RS21540	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NXX00_RS21540	COG1918	ferrous iron import across plasma membrane
NXX00_RS21545	COG0037	tRNA processing
NXX00_RS21560	COG3119	arylsulfatase activity
NXX00_RS21570	COG2205	protein histidine kinase activity
NXX00_RS21570	COG2202	Pas domain
NXX00_RS21575	COG0534	Mate efflux family protein
NXX00_RS21580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NXX00_RS21605	COG1858	cytochrome C peroxidase
NXX00_RS21610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NXX00_RS21685	COG3328	transposase activity
NXX00_RS21745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NXX00_RS21770	COG1983	PspC domain protein
NXX00_RS21775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NXX00_RS21835	COG3119	arylsulfatase activity
NXX00_RS21840	COG0668	transmembrane transport
NXX00_RS21845	COG3119	arylsulfatase activity
NXX00_RS21855	COG3250	beta-galactosidase activity
NXX00_RS21860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NXX00_RS21865	COG3119	arylsulfatase activity
NXX00_RS21875	COG0702	epimerase
NXX00_RS21880	COG4206	TonB-dependent receptor
NXX00_RS21880	COG1629	transport
NXX00_RS21890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NXX00_RS21895	COG1660	Displays ATPase and GTPase activities
NXX00_RS21900	COG3292	Two component regulator propeller
NXX00_RS21900	COG0745	RESPONSE REGULATOR receiver
NXX00_RS21900	COG2205	protein histidine kinase activity
NXX00_RS21900	COG3292	Two component regulator propeller
NXX00_RS21900	COG0745	RESPONSE REGULATOR receiver
NXX00_RS21900	COG2205	protein histidine kinase activity
NXX00_RS21905	COG3119	arylsulfatase activity
NXX00_RS21960	COG1091	dTDP-4-dehydrorhamnose reductase activity
NXX00_RS21975	COG0438	transferase activity, transferring glycosyl groups
NXX00_RS21985	COG1216	Glycosyl transferase, family 2
NXX00_RS22040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NXX00_RS22045	COG1830	Aldolase
NXX00_RS22050	COG0588	phosphoglycerate mutase activity
NXX00_RS22055	COG5002	protein histidine kinase activity
NXX00_RS22055	COG2205	protein histidine kinase activity
NXX00_RS22055	COG0784	Response regulator, receiver
NXX00_RS22060	COG1119	ATPase activity
NXX00_RS22065	COG1523	belongs to the glycosyl hydrolase 13 family
NXX00_RS22070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NXX00_RS22325	COG0560	Phosphoserine phosphatase
NXX00_RS22340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NXX00_RS22345	COG2814	Major facilitator Superfamily
NXX00_RS22350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NXX00_RS22375	COG0424	maF-like protein
NXX00_RS22395	COG0778	Nitroreductase
NXX00_RS22405	COG0288	reversible hydration of carbon dioxide
NXX00_RS22415	COG4771	TonB-dependent receptor
NXX00_RS22430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NXX00_RS22440	COG0511	ligase activity, forming carbon-carbon bonds
NXX00_RS22445	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NXX00_RS22455	COG0191	fructose-bisphosphate aldolase activity
NXX00_RS22460	COG0254	rRNA binding
NXX00_RS22465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NXX00_RS22470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NXX00_RS22535	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS22540	COG3475	LICD family
NXX00_RS22545	COG1215	transferase activity, transferring glycosyl groups
NXX00_RS22555	COG3475	LICD family
NXX00_RS22585	COG4750	Nucleotidyl transferase
NXX00_RS22625	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NXX00_RS22650	COG2205	protein histidine kinase activity
NXX00_RS22650	COG0745	RESPONSE REGULATOR receiver
NXX00_RS22650	COG0745	RESPONSE REGULATOR receiver
NXX00_RS22650	COG3292	Two component regulator propeller
NXX00_RS22650	COG3292	Two component regulator propeller
NXX00_RS22650	COG2205	protein histidine kinase activity
NXX00_RS22665	COG1649	PFAM Uncharacterised BCR, COG1649
NXX00_RS22690	COG1966	Carbon starvation protein
NXX00_RS22725	COG2113	Glycine betaine
NXX00_RS22730	COG4176	ABC-type proline glycine betaine transport system permease component
NXX00_RS22750	COG2205	protein histidine kinase activity
NXX00_RS22750	COG3292	Two component regulator propeller
NXX00_RS22750	COG0745	RESPONSE REGULATOR receiver
NXX00_RS22760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NXX00_RS22760	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NXX00_RS22770	COG1621	beta-fructofuranosidase activity
NXX00_RS22785	COG0561	phosphatase activity
NXX00_RS22790	COG1629	transport
NXX00_RS22790	COG4206	TonB-dependent receptor
NXX00_RS22805	COG1621	beta-fructofuranosidase activity
NXX00_RS22825	COG3537	Alpha-1,2-mannosidase
NXX00_RS22850	COG1629	transport
NXX00_RS22860	COG3250	beta-galactosidase activity
NXX00_RS22870	COG1472	Belongs to the glycosyl hydrolase 3 family
NXX00_RS22880	COG1472	Belongs to the glycosyl hydrolase 3 family
NXX00_RS22890	COG1752	Esterase of the alpha-beta hydrolase superfamily
NXX00_RS22895	COG0475	glutathione-regulated potassium exporter activity
NXX00_RS22930	COG3279	Response regulator of the LytR AlgR family
NXX00_RS22960	COG2205	protein histidine kinase activity
NXX00_RS22965	COG2205	protein histidine kinase activity
NXX00_RS22980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NXX00_RS22985	COG1960	acyl-CoA dehydrogenase activity
NXX00_RS23005	COG1956	GAF domain-containing protein
NXX00_RS23015	COG0484	heat shock protein binding
NXX00_RS23020	COG2194	sulfuric ester hydrolase activity
NXX00_RS23055	COG0028	Belongs to the TPP enzyme family
NXX00_RS23095	COG0459	protein refolding
NXX00_RS23100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NXX00_RS23115	COG5002	protein histidine kinase activity
NXX00_RS23115	COG0784	Response regulator, receiver
NXX00_RS23115	COG2205	protein histidine kinase activity
NXX00_RS23130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NXX00_RS23140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NXX00_RS23145	COG1506	peptidase
NXX00_RS23145	COG0823	Involved in the tonB-independent uptake of proteins
NXX00_RS23155	COG0124	histidyl-tRNA synthetase
NXX00_RS23170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NXX00_RS23210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NXX00_RS23220	COG0671	phosphoesterase, PA-phosphatase related
NXX00_RS23235	COG0473	3-isopropylmalate dehydrogenase activity
NXX00_RS23250	COG0066	3-isopropylmalate dehydratase activity
NXX00_RS23255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NXX00_RS23260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NXX00_RS23295	COG4948	Mandelate Racemase Muconate Lactonizing
NXX00_RS23305	COG3507	Belongs to the glycosyl hydrolase 43 family
NXX00_RS23310	COG0702	epimerase
NXX00_RS23320	COG4771	TonB-dependent receptor
NXX00_RS23340	COG0616	signal peptide processing
NXX00_RS23345	COG1663	tetraacyldisaccharide 4'-kinase activity
NXX00_RS23350	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NXX00_RS23355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NXX00_RS23375	COG0513	Belongs to the DEAD box helicase family
NXX00_RS23380	COG2070	2-Nitropropane dioxygenase
NXX00_RS23385	COG0724	RNA recognition motif
NXX00_RS23400	COG3973	AAA domain
NXX00_RS23475	COG0358	DNA primase activity
NXX00_RS23600	COG2198	Histidine kinase
NXX00_RS23600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NXX00_RS23600	COG0784	Response regulator, receiver
NXX00_RS23600	COG2205	protein histidine kinase activity
NXX00_RS23620	COG0551	DNA topoisomerase type I activity
NXX00_RS23620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NXX00_RS23655	COG4974	Belongs to the 'phage' integrase family
NXX00_RS23675	COG1704	LemA family
NXX00_RS23690	COG0534	Mate efflux family protein
NXX00_RS23700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NXX00_RS23710	COG1917	Cupin 2, conserved barrel domain protein
NXX00_RS23710	COG4977	sequence-specific DNA binding
NXX00_RS23740	COG1028	Short-chain dehydrogenase reductase Sdr
NXX00_RS23760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NXX00_RS23770	COG0439	Biotin carboxylase
NXX00_RS23775	COG5016	pyruvate
NXX00_RS23775	COG0511	ligase activity, forming carbon-carbon bonds
NXX00_RS23780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NXX00_RS23790	COG2855	membrane
NXX00_RS23800	COG2873	o-acetylhomoserine
NXX00_RS23840	COG1538	Outer membrane efflux protein
NXX00_RS23860	COG2814	Major facilitator Superfamily
NXX00_RS23890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NXX00_RS23905	COG0024	Methionine aminopeptidase
NXX00_RS23910	COG0617	tRNA 3'-terminal CCA addition
NXX00_RS23930	COG0632	four-way junction helicase activity
NXX00_RS23935	COG0673	inositol 2-dehydrogenase activity
NXX00_RS23950	COG1272	protein, Hemolysin III
NXX00_RS23965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NXX00_RS23990	COG3023	N-Acetylmuramoyl-L-alanine amidase
NXX00_RS24025	COG1328	CTP reductase activity
NXX00_RS24035	COG2814	Major facilitator Superfamily
NXX00_RS24040	COG0750	zinc metalloprotease
NXX00_RS24045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NXX00_RS24055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NXX00_RS24060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NXX00_RS24120	COG1342	Belongs to the UPF0251 family
NXX00_RS24240	COG2207	Transcriptional regulator
NXX00_RS24240	COG4753	response regulator
NXX00_RS24340	COG0194	GDP metabolic process
NXX00_RS24345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NXX00_RS24350	COG1408	metallophosphoesterase
NXX00_RS24360	COG1088	dTDP-glucose 4,6-dehydratase activity
NXX00_RS24365	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NXX00_RS24375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NXX00_RS24395	COG2205	protein histidine kinase activity
NXX00_RS24395	COG2202	Pas domain
NXX00_RS24425	COG3023	N-Acetylmuramoyl-L-alanine amidase
NXX00_RS24440	COG4771	TonB-dependent receptor
NXX00_RS24455	COG0784	Response regulator, receiver
NXX00_RS24455	COG2205	protein histidine kinase activity
NXX00_RS24460	COG0488	(ABC) transporter
NXX00_RS24510	COG1595	DNA-templated transcription, initiation
NXX00_RS24525	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NXX00_RS24535	COG1522	sequence-specific DNA binding
NXX00_RS24565	COG0811	peptide transport
NXX00_RS24575	COG0084	hydrolase, TatD family'
NXX00_RS24595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NXX00_RS24600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NXX00_RS24605	COG0205	6-phosphofructokinase activity
NXX00_RS24655	COG0372	Belongs to the citrate synthase family
NXX00_RS24660	COG0538	isocitrate dehydrogenase activity
NXX00_RS24665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NXX00_RS24670	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NXX00_RS24675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NXX00_RS24690	COG0028	Belongs to the TPP enzyme family
NXX00_RS24695	COG0129	dihydroxy-acid dehydratase activity
NXX00_RS24705	COG1047	Peptidyl-prolyl cis-trans
NXX00_RS24710	COG3681	Belongs to the UPF0597 family
NXX00_RS24730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NXX00_RS24755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NXX00_RS24755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NXX00_RS24760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NXX00_RS24775	COG2985	domain, Protein
NXX00_RS24775	COG0569	domain protein
NXX00_RS24820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NXX00_RS24825	COG1120	ATPase activity
NXX00_RS24840	COG2188	Transcriptional regulator
NXX00_RS24870	COG4206	TonB-dependent receptor
NXX00_RS24870	COG1629	transport
NXX00_RS24935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NXX00_RS24940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NXX00_RS24945	COG0166	Belongs to the GPI family
NXX00_RS24975	COG2502	aspartate--ammonia ligase
NXX00_RS24980	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NXX00_RS25005	COG3876	Protein conserved in bacteria
NXX00_RS25025	COG3340	Belongs to the peptidase S51 family
NXX00_RS25030	COG2378	regulation of single-species biofilm formation
NXX00_RS25065	COG0358	DNA primase activity
NXX00_RS25095	COG0860	N-Acetylmuramoyl-L-alanine amidase