locus-tag	class	description
KHO74_RS00070	COG4771	TonB-dependent receptor
KHO74_RS00105	COG2755	lipolytic protein G-D-S-L family
KHO74_RS00105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KHO74_RS00140	COG4771	TonB-dependent receptor
KHO74_RS00150	COG2814	Major facilitator Superfamily
KHO74_RS00160	COG2081	HI0933 family
KHO74_RS00165	COG1940	carbohydrate kinase activity
KHO74_RS00180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KHO74_RS00190	COG0674	pyruvate-flavodoxin oxidoreductase activity
KHO74_RS00190	COG1013	pyruvate-flavodoxin oxidoreductase activity
KHO74_RS00190	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KHO74_RS00190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KHO74_RS00195	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KHO74_RS00200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KHO74_RS00210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KHO74_RS00215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KHO74_RS00220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KHO74_RS00225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KHO74_RS00235	COG0242	peptide deformylase activity
KHO74_RS00240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KHO74_RS00260	COG2895	sulfate adenylyltransferase (ATP) activity
KHO74_RS00265	COG0175	sulfate reduction
KHO74_RS00270	COG0529	Catalyzes the synthesis of activated sulfate
KHO74_RS00275	COG0471	metal ion transport
KHO74_RS00275	COG3273	potassium ion transport
KHO74_RS00280	COG1218	3'(2'),5'-bisphosphate nucleotidase
KHO74_RS00290	COG4221	oxidoreductase activity
KHO74_RS00395	COG0740	serine-type endopeptidase activity
KHO74_RS00400	COG3415	Transposase
KHO74_RS00415	COG4383	Mu-like prophage protein gp29
KHO74_RS00580	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS00600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KHO74_RS00610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KHO74_RS00665	COG1216	Glycosyl transferase, family 2
KHO74_RS00670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KHO74_RS00680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KHO74_RS00750	COG1482	cell wall glycoprotein biosynthetic process
KHO74_RS00765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KHO74_RS00770	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO74_RS00780	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO74_RS00785	COG0745	RESPONSE REGULATOR receiver
KHO74_RS00785	COG2205	protein histidine kinase activity
KHO74_RS00785	COG3292	Two component regulator propeller
KHO74_RS00795	COG4206	TonB-dependent receptor
KHO74_RS00795	COG1629	transport
KHO74_RS00800	COG0702	epimerase
KHO74_RS00805	COG4206	TonB-dependent receptor
KHO74_RS00805	COG1629	transport
KHO74_RS00810	COG0702	epimerase
KHO74_RS00845	COG2160	L-arabinose isomerase activity
KHO74_RS00850	COG1070	Carbohydrate kinase
KHO74_RS00865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KHO74_RS00870	COG0698	ribose 5-phosphate isomerase
KHO74_RS00890	COG5012	cobalamin binding
KHO74_RS00895	COG1501	Belongs to the glycosyl hydrolase 31 family
KHO74_RS00910	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KHO74_RS00955	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KHO74_RS00980	COG0673	inositol 2-dehydrogenase activity
KHO74_RS00985	COG0590	tRNA wobble adenosine to inosine editing
KHO74_RS01000	COG4206	TonB-dependent receptor
KHO74_RS01000	COG1629	transport
KHO74_RS01020	COG2433	Pfam Transposase IS66
KHO74_RS01040	COG2264	protein methyltransferase activity
KHO74_RS01050	COG0022	dehydrogenase e1 component
KHO74_RS01055	COG0508	dehydrogenase complex catalyzes the overall conversion of
KHO74_RS01080	COG1538	Outer membrane efflux protein
KHO74_RS01095	COG1752	Esterase of the alpha-beta hydrolase superfamily
KHO74_RS01130	COG1131	(ABC) transporter
KHO74_RS01175	COG0848	biopolymer transport protein
KHO74_RS01180	COG0811	peptide transport
KHO74_RS01245	COG4771	TonB-dependent receptor
KHO74_RS01260	COG0702	epimerase
KHO74_RS01270	COG1629	transport
KHO74_RS01275	COG3292	Two component regulator propeller
KHO74_RS01275	COG2205	protein histidine kinase activity
KHO74_RS01275	COG0745	RESPONSE REGULATOR receiver
KHO74_RS01310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KHO74_RS01315	COG0363	glucosamine-6-phosphate deaminase activity
KHO74_RS01335	COG1032	radical SAM domain protein
KHO74_RS01345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KHO74_RS01350	COG0463	Glycosyl transferase, family 2
KHO74_RS01360	COG0646	methionine synthase
KHO74_RS01360	COG1410	methionine synthase
KHO74_RS01375	COG1408	metallophosphoesterase
KHO74_RS01385	COG0420	3'-5' exonuclease activity
KHO74_RS01415	COG0641	radical SAM
KHO74_RS01420	COG3591	Belongs to the peptidase S1B family
KHO74_RS01425	COG3591	Belongs to the peptidase S1B family
KHO74_RS01455	COG1592	Rubrerythrin
KHO74_RS01455	COG1773	rubredoxin
KHO74_RS01475	COG1404	Belongs to the peptidase S8 family
KHO74_RS01505	COG4771	TonB-dependent receptor
KHO74_RS01510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KHO74_RS01510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KHO74_RS01520	COG0131	Imidazoleglycerol-phosphate dehydratase
KHO74_RS01525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KHO74_RS01530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KHO74_RS01535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KHO74_RS01555	COG2271	Major facilitator Superfamily
KHO74_RS01580	COG0702	epimerase
KHO74_RS01585	COG1629	transport
KHO74_RS01600	COG1741	Belongs to the pirin family
KHO74_RS01605	COG4232	protein-disulfide reductase activity
KHO74_RS01615	COG0572	uridine kinase
KHO74_RS01625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KHO74_RS01630	COG0778	Nitroreductase
KHO74_RS01635	COG0646	methionine synthase
KHO74_RS01635	COG1410	methionine synthase
KHO74_RS01640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KHO74_RS01705	COG0545	Peptidyl-prolyl cis-trans isomerase
KHO74_RS01710	COG2373	Large extracellular alpha-helical protein
KHO74_RS01715	COG4953	penicillin-binding protein 1C
KHO74_RS01720	COG2814	Major facilitator Superfamily
KHO74_RS01735	COG1757	Na H antiporter
KHO74_RS01745	COG2197	response regulator
KHO74_RS01750	COG0482	sulfurtransferase activity
KHO74_RS01755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KHO74_RS01780	COG0501	Belongs to the peptidase M48B family
KHO74_RS01785	COG1253	flavin adenine dinucleotide binding
KHO74_RS01795	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KHO74_RS01810	COG5492	domain, Protein
KHO74_RS01820	COG4206	TonB-dependent receptor
KHO74_RS01820	COG1629	transport
KHO74_RS01825	COG1595	DNA-templated transcription, initiation
KHO74_RS01830	COG3292	Two component regulator propeller
KHO74_RS01830	COG2205	protein histidine kinase activity
KHO74_RS01830	COG0745	RESPONSE REGULATOR receiver
KHO74_RS01830	COG3292	Two component regulator propeller
KHO74_RS01830	COG2205	protein histidine kinase activity
KHO74_RS01830	COG0745	RESPONSE REGULATOR receiver
KHO74_RS01855	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KHO74_RS01860	COG1082	Xylose isomerase domain protein TIM barrel
KHO74_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
KHO74_RS01905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHO74_RS01920	COG1882	Formate acetyltransferase
KHO74_RS01925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KHO74_RS01930	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS01975	COG2271	Major facilitator Superfamily
KHO74_RS01980	COG0584	glycerophosphoryl diester phosphodiesterase
KHO74_RS01985	COG0584	glycerophosphoryl diester phosphodiesterase
KHO74_RS01995	COG4771	TonB-dependent receptor
KHO74_RS02005	COG1595	DNA-templated transcription, initiation
KHO74_RS02025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KHO74_RS02035	COG0583	DNA-binding transcription factor activity
KHO74_RS02040	COG0783	Belongs to the Dps family
KHO74_RS02080	COG1629	transport
KHO74_RS02080	COG4206	TonB-dependent receptor
KHO74_RS02095	COG0318	PFAM AMP-dependent synthetase and ligase
KHO74_RS02100	COG4948	Mandelate Racemase Muconate Lactonizing
KHO74_RS02105	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KHO74_RS02110	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KHO74_RS02115	COG1169	isochorismate synthase
KHO74_RS02120	COG0561	phosphatase activity
KHO74_RS02125	COG3189	MarR family transcriptional regulator
KHO74_RS02135	COG0456	acetyltransferase
KHO74_RS02140	COG1538	Outer membrane efflux protein
KHO74_RS02150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS02160	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KHO74_RS02170	COG1523	belongs to the glycosyl hydrolase 13 family
KHO74_RS02175	COG0668	transmembrane transport
KHO74_RS02190	COG1629	transport
KHO74_RS02200	COG3250	beta-galactosidase activity
KHO74_RS02215	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS02230	COG4206	TonB-dependent receptor
KHO74_RS02230	COG1629	transport
KHO74_RS02250	COG4804	nuclease activity
KHO74_RS02295	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KHO74_RS02310	COG1193	negative regulation of DNA recombination
KHO74_RS02315	COG0598	Magnesium transport protein CorA
KHO74_RS02320	COG1760	l-serine dehydratase
KHO74_RS02345	COG3292	Two component regulator propeller
KHO74_RS02345	COG2205	protein histidine kinase activity
KHO74_RS02345	COG0745	RESPONSE REGULATOR receiver
KHO74_RS02355	COG4206	TonB-dependent receptor
KHO74_RS02355	COG1629	transport
KHO74_RS02360	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KHO74_RS02375	COG3250	beta-galactosidase activity
KHO74_RS02385	COG0156	8-amino-7-oxononanoate synthase activity
KHO74_RS02425	COG1404	Belongs to the peptidase S8 family
KHO74_RS02425	COG4935	Belongs to the peptidase S8 family
KHO74_RS02445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KHO74_RS02450	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KHO74_RS02455	COG0745	RESPONSE REGULATOR receiver
KHO74_RS02455	COG3292	Two component regulator propeller
KHO74_RS02455	COG2205	protein histidine kinase activity
KHO74_RS02460	COG5434	Belongs to the glycosyl hydrolase 28 family
KHO74_RS02470	COG4771	TonB-dependent receptor
KHO74_RS02475	COG0702	epimerase
KHO74_RS02480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KHO74_RS02490	COG3119	arylsulfatase activity
KHO74_RS02515	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KHO74_RS02520	COG0038	chloride channel
KHO74_RS02570	COG0586	Pfam SNARE associated Golgi protein
KHO74_RS02580	COG0306	phosphate transporter
KHO74_RS02605	COG0326	Molecular chaperone. Has ATPase activity
KHO74_RS02670	COG0443	Heat shock 70 kDa protein
KHO74_RS02690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KHO74_RS02695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KHO74_RS02700	COG2855	membrane
KHO74_RS02710	COG0583	DNA-binding transcription factor activity
KHO74_RS02720	COG0542	response to heat
KHO74_RS02735	COG0237	dephospho-CoA kinase activity
KHO74_RS02745	COG1862	Preprotein translocase
KHO74_RS02750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KHO74_RS02760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KHO74_RS02765	COG0193	aminoacyl-tRNA hydrolase activity
KHO74_RS02770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KHO74_RS02780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KHO74_RS02780	COG4651	solute:proton antiporter activity
KHO74_RS02785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KHO74_RS02790	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHO74_RS02795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KHO74_RS02800	COG1082	Xylose isomerase domain protein TIM barrel
KHO74_RS02815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KHO74_RS02825	COG0148	phosphopyruvate hydratase activity
KHO74_RS02830	COG1595	DNA-templated transcription, initiation
KHO74_RS02855	COG3279	Response regulator of the LytR AlgR family
KHO74_RS02870	COG0463	Glycosyl transferase, family 2
KHO74_RS02885	COG1971	Probably functions as a manganese efflux pump
KHO74_RS02890	COG1477	protein flavinylation
KHO74_RS02900	COG0037	tRNA processing
KHO74_RS02915	COG4864	UPF0365 protein
KHO74_RS02925	COG2910	NAD(P)H-binding
KHO74_RS02935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KHO74_RS03045	COG3328	transposase activity
KHO74_RS03105	COG0653	protein targeting
KHO74_RS03115	COG0346	lactoylglutathione lyase activity
KHO74_RS03150	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KHO74_RS03155	COG3408	Glycogen debranching enzyme
KHO74_RS03170	COG0657	acetylesterase activity
KHO74_RS03175	COG0702	epimerase
KHO74_RS03180	COG1629	transport
KHO74_RS03185	COG0662	Cupin 2, conserved barrel domain protein
KHO74_RS03185	COG2207	Transcriptional regulator
KHO74_RS03190	COG0564	pseudouridine synthase activity
KHO74_RS03200	COG0534	Mate efflux family protein
KHO74_RS03215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KHO74_RS03245	COG0741	lytic transglycosylase activity
KHO74_RS03245	COG1388	LysM domain
KHO74_RS03250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KHO74_RS03260	COG1285	pathogenesis
KHO74_RS03300	COG1115	amino acid carrier protein
KHO74_RS03310	COG1509	lysine 2,3-aminomutase activity
KHO74_RS03315	COG2233	PERMEase
KHO74_RS03330	COG1629	transport
KHO74_RS03330	COG4206	TonB-dependent receptor
KHO74_RS03340	COG1393	Belongs to the ArsC family
KHO74_RS03350	COG2304	oxidoreductase activity
KHO74_RS03370	COG0351	phosphomethylpyrimidine kinase
KHO74_RS03380	COG1139	Iron-sulfur cluster binding protein
KHO74_RS03385	COG0247	lactate metabolic process
KHO74_RS03390	COG0602	queuosine metabolic process
KHO74_RS03400	COG2832	Protein of unknown function (DUF454)
KHO74_RS03405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KHO74_RS03415	COG0673	inositol 2-dehydrogenase activity
KHO74_RS03455	COG1333	cytochrome c biogenesis protein
KHO74_RS03455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KHO74_RS03480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KHO74_RS03485	COG1063	alcohol dehydrogenase
KHO74_RS03490	COG1070	Carbohydrate kinase
KHO74_RS03520	COG1418	mRNA catabolic process
KHO74_RS03525	COG3142	Participates in the control of copper homeostasis
KHO74_RS03590	COG4206	TonB-dependent receptor
KHO74_RS03590	COG1629	transport
KHO74_RS03685	COG2706	6-phosphogluconolactonase activity
KHO74_RS03690	COG0457	Tetratricopeptide repeat
KHO74_RS03695	COG2814	Major facilitator Superfamily
KHO74_RS03705	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS03710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS03725	COG1496	oxidoreductase activity
KHO74_RS03730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KHO74_RS03735	COG0563	adenylate kinase activity
KHO74_RS03740	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KHO74_RS03760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KHO74_RS03760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KHO74_RS03800	COG2204	response regulator
KHO74_RS03805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KHO74_RS03815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KHO74_RS03825	COG1253	flavin adenine dinucleotide binding
KHO74_RS03845	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KHO74_RS03855	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
KHO74_RS03860	COG0653	protein targeting
KHO74_RS03885	COG4206	TonB-dependent receptor
KHO74_RS03885	COG1629	transport
KHO74_RS03900	COG0784	Response regulator, receiver
KHO74_RS03900	COG2205	protein histidine kinase activity
KHO74_RS03900	COG5002	protein histidine kinase activity
KHO74_RS03905	COG0525	valine-tRNA ligase activity
KHO74_RS03920	COG3956	TIGRFAM MazG family protein
KHO74_RS03940	COG1234	tRNA 3'-trailer cleavage
KHO74_RS03950	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KHO74_RS03950	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KHO74_RS03980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS03985	COG0492	ferredoxin-NADP+ reductase activity
KHO74_RS03995	COG1674	ftsk spoiiie
KHO74_RS04010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KHO74_RS04015	COG2211	Major facilitator Superfamily
KHO74_RS04035	COG1136	(ABC) transporter
KHO74_RS04050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KHO74_RS04055	COG1597	lipid kinase activity
KHO74_RS04060	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KHO74_RS04065	COG0612	Peptidase, M16
KHO74_RS04080	COG0791	NLP P60 protein
KHO74_RS04095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KHO74_RS04100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KHO74_RS04105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KHO74_RS04115	COG0543	2 iron, 2 sulfur cluster binding
KHO74_RS04120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KHO74_RS04125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KHO74_RS04130	COG0297	glycogen (starch) synthase activity
KHO74_RS04145	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS04175	COG4771	TonB-dependent receptor
KHO74_RS04245	COG1216	Glycosyl transferase, family 2
KHO74_RS04250	COG2433	Pfam Transposase IS66
KHO74_RS04270	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS04350	COG0484	heat shock protein binding
KHO74_RS04390	COG0358	DNA primase activity
KHO74_RS04470	COG1192	Involved in chromosome partitioning
KHO74_RS04510	COG1373	ATPase (AAA superfamily
KHO74_RS04530	COG0551	DNA topoisomerase type I activity
KHO74_RS04530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KHO74_RS04620	COG2204	response regulator
KHO74_RS04650	COG4974	Belongs to the 'phage' integrase family
KHO74_RS04690	COG4771	TonB-dependent receptor
KHO74_RS04705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KHO74_RS04705	COG0519	Catalyzes the synthesis of GMP from XMP
KHO74_RS04710	COG1970	mechanosensitive ion channel activity
KHO74_RS04720	COG0339	signal peptide processing
KHO74_RS04730	COG2131	deaminase
KHO74_RS04735	COG0793	Belongs to the peptidase S41A family
KHO74_RS04740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KHO74_RS04745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KHO74_RS04755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHO74_RS04765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KHO74_RS04780	COG0673	inositol 2-dehydrogenase activity
KHO74_RS04785	COG5434	Belongs to the glycosyl hydrolase 28 family
KHO74_RS04805	COG4771	TonB-dependent receptor
KHO74_RS04825	COG0673	inositol 2-dehydrogenase activity
KHO74_RS04830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KHO74_RS04835	COG3250	beta-galactosidase activity
KHO74_RS04855	COG0101	tRNA pseudouridine synthase activity
KHO74_RS04860	COG2205	protein histidine kinase activity
KHO74_RS04860	COG0745	RESPONSE REGULATOR receiver
KHO74_RS04860	COG3292	Two component regulator propeller
KHO74_RS04895	COG5433	transposase activity
KHO74_RS04955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHO74_RS04975	COG2268	Band 7 protein
KHO74_RS04985	COG1702	phosphate starvation-inducible protein PhoH
KHO74_RS04990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KHO74_RS04995	COG2226	methyltransferase
KHO74_RS05000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KHO74_RS05015	COG1704	LemA family
KHO74_RS05025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KHO74_RS05030	COG0284	orotidine-5'-phosphate decarboxylase activity
KHO74_RS05035	COG1078	dGTPase activity
KHO74_RS05040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KHO74_RS05045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KHO74_RS05045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KHO74_RS05060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KHO74_RS05105	COG1506	peptidase
KHO74_RS05105	COG0823	Involved in the tonB-independent uptake of proteins
KHO74_RS05110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KHO74_RS05120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KHO74_RS05130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KHO74_RS05150	COG0546	phosphoglycolate phosphatase activity
KHO74_RS05160	COG0745	RESPONSE REGULATOR receiver
KHO74_RS05160	COG2205	protein histidine kinase activity
KHO74_RS05160	COG3292	Two component regulator propeller
KHO74_RS05165	COG3250	beta-galactosidase activity
KHO74_RS05180	COG2205	protein histidine kinase activity
KHO74_RS05180	COG3292	Two component regulator propeller
KHO74_RS05180	COG2205	protein histidine kinase activity
KHO74_RS05180	COG3292	Two component regulator propeller
KHO74_RS05180	COG0745	RESPONSE REGULATOR receiver
KHO74_RS05180	COG0745	RESPONSE REGULATOR receiver
KHO74_RS05185	COG3254	rhamnose metabolic process
KHO74_RS05195	COG3401	FG-GAP repeat protein
KHO74_RS05205	COG2755	lipolytic protein G-D-S-L family
KHO74_RS05230	COG4771	TonB-dependent receptor
KHO74_RS05245	COG0702	epimerase
KHO74_RS05250	COG4771	TonB-dependent receptor
KHO74_RS05275	COG3328	transposase activity
KHO74_RS05285	COG4771	TonB-dependent receptor
KHO74_RS05290	COG0702	epimerase
KHO74_RS05305	COG4771	TonB-dependent receptor
KHO74_RS05345	COG3345	alpha-galactosidase
KHO74_RS05355	COG3250	beta-galactosidase activity
KHO74_RS05360	COG3401	FG-GAP repeat protein
KHO74_RS05395	COG2755	lipolytic protein G-D-S-L family
KHO74_RS05420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KHO74_RS05465	COG1595	DNA-templated transcription, initiation
KHO74_RS05470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KHO74_RS05470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KHO74_RS05475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KHO74_RS05480	COG0569	domain protein
KHO74_RS05480	COG2985	domain, Protein
KHO74_RS05520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KHO74_RS05525	COG1120	ATPase activity
KHO74_RS05540	COG2188	Transcriptional regulator
KHO74_RS05560	COG4206	TonB-dependent receptor
KHO74_RS05560	COG1629	transport
KHO74_RS05735	COG4383	Mu-like prophage protein gp29
KHO74_RS05750	COG3415	Transposase
KHO74_RS05755	COG0740	serine-type endopeptidase activity
KHO74_RS05830	COG4771	TonB-dependent receptor
KHO74_RS05890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS05895	COG2207	Transcriptional regulator
KHO74_RS05895	COG1609	Transcriptional regulator
KHO74_RS05905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KHO74_RS05910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KHO74_RS05915	COG0166	Belongs to the GPI family
KHO74_RS06015	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS06060	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KHO74_RS06065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KHO74_RS06070	COG1086	Polysaccharide biosynthesis protein
KHO74_RS06165	COG2502	aspartate--ammonia ligase
KHO74_RS06170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KHO74_RS06195	COG3876	Protein conserved in bacteria
KHO74_RS06215	COG0860	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS06225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KHO74_RS06230	COG0778	Nitroreductase
KHO74_RS06235	COG4974	Belongs to the 'phage' integrase family
KHO74_RS06310	COG1640	4-alpha-glucanotransferase
KHO74_RS06325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KHO74_RS06345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KHO74_RS06350	COG0318	PFAM AMP-dependent synthetase and ligase
KHO74_RS06385	COG0359	binds to the 23S rRNA
KHO74_RS06390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KHO74_RS06395	COG0360	Binds together with S18 to 16S ribosomal RNA
KHO74_RS06420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KHO74_RS06425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KHO74_RS06480	COG1131	(ABC) transporter
KHO74_RS06490	COG2431	L-lysine efflux transmembrane transporter activity
KHO74_RS06500	COG1193	negative regulation of DNA recombination
KHO74_RS06525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KHO74_RS06540	COG2234	aminopeptidase activity
KHO74_RS06545	COG3250	beta-galactosidase activity
KHO74_RS06565	COG0702	epimerase
KHO74_RS06570	COG1629	transport
KHO74_RS06585	COG3537	Alpha-1,2-mannosidase
KHO74_RS06600	COG4206	TonB-dependent receptor
KHO74_RS06600	COG1629	transport
KHO74_RS06620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KHO74_RS06625	COG0802	atpase or kinase
KHO74_RS06640	COG0714	Associated with various cellular activities
KHO74_RS06690	COG3118	belongs to the thioredoxin family
KHO74_RS06700	COG0688	phosphatidylethanolamine metabolic process
KHO74_RS06705	COG1183	phosphatidylcholine synthase activity
KHO74_RS06725	COG0792	nuclease activity
KHO74_RS06750	COG0534	Mate efflux family protein
KHO74_RS06755	COG0528	UMP kinase activity
KHO74_RS06790	COG0233	cytoplasmic translational termination
KHO74_RS06795	COG1162	GTPase activity
KHO74_RS06805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KHO74_RS06825	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KHO74_RS06825	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KHO74_RS06835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KHO74_RS06845	COG4206	TonB-dependent receptor
KHO74_RS06845	COG1629	transport
KHO74_RS06850	COG4974	Belongs to the 'phage' integrase family
KHO74_RS06855	COG1629	transport
KHO74_RS06875	COG4771	TonB-dependent receptor
KHO74_RS06885	COG2095	MarC family integral membrane protein
KHO74_RS06900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KHO74_RS06910	COG1435	thymidine kinase activity
KHO74_RS06915	COG0628	permease
KHO74_RS06955	COG2433	Pfam Transposase IS66
KHO74_RS06995	COG1396	sequence-specific DNA binding
KHO74_RS07005	COG4771	TonB-dependent receptor
KHO74_RS07015	COG4771	TonB-dependent receptor
KHO74_RS07050	COG0693	protein deglycase activity
KHO74_RS07120	COG0300	oxidoreductase activity
KHO74_RS07125	COG3328	transposase activity
KHO74_RS07130	COG0456	acetyltransferase
KHO74_RS07135	COG0110	maltose O-acetyltransferase activity
KHO74_RS07145	COG1522	sequence-specific DNA binding
KHO74_RS07170	COG3292	Two component regulator propeller
KHO74_RS07170	COG2205	protein histidine kinase activity
KHO74_RS07170	COG0745	RESPONSE REGULATOR receiver
KHO74_RS07180	COG1629	transport
KHO74_RS07205	COG2818	Glycosylase
KHO74_RS07215	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
KHO74_RS07220	COG0527	aspartate kinase activity
KHO74_RS07220	COG0460	homoserine dehydrogenase
KHO74_RS07225	COG0252	asparaginase activity
KHO74_RS07235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KHO74_RS07240	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KHO74_RS07250	COG4771	TonB-dependent receptor
KHO74_RS07275	COG0826	peptidase U32
KHO74_RS07280	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KHO74_RS07290	COG0436	Aminotransferase
KHO74_RS07295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KHO74_RS07315	COG0519	Catalyzes the synthesis of GMP from XMP
KHO74_RS07320	COG5002	protein histidine kinase activity
KHO74_RS07325	COG2205	protein histidine kinase activity
KHO74_RS07335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KHO74_RS07345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KHO74_RS07380	COG2193	ferroxidase activity
KHO74_RS07390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KHO74_RS07395	COG0470	DNA polymerase III
KHO74_RS07400	COG1774	PSP1 C-terminal conserved region
KHO74_RS07410	COG0772	Belongs to the SEDS family
KHO74_RS07435	COG0138	bifunctional purine biosynthesis protein purh
KHO74_RS07440	COG3590	peptidase
KHO74_RS07445	COG0488	(ABC) transporter
KHO74_RS07470	COG2205	protein histidine kinase activity
KHO74_RS07470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHO74_RS07475	COG0534	Mate efflux family protein
KHO74_RS07480	COG0612	Peptidase, M16
KHO74_RS07485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KHO74_RS07490	COG2204	response regulator
KHO74_RS07495	COG0745	RESPONSE REGULATOR receiver
KHO74_RS07495	COG3292	Two component regulator propeller
KHO74_RS07495	COG2205	protein histidine kinase activity
KHO74_RS07500	COG3119	arylsulfatase activity
KHO74_RS07515	COG3119	arylsulfatase activity
KHO74_RS07545	COG4771	TonB-dependent receptor
KHO74_RS07555	COG0745	RESPONSE REGULATOR receiver
KHO74_RS07555	COG2205	protein histidine kinase activity
KHO74_RS07555	COG3292	Two component regulator propeller
KHO74_RS07560	COG3537	Alpha-1,2-mannosidase
KHO74_RS07620	COG0564	pseudouridine synthase activity
KHO74_RS07650	COG1454	alcohol dehydrogenase
KHO74_RS07655	COG0235	Class ii aldolase
KHO74_RS07665	COG4806	L-rhamnose isomerase
KHO74_RS07670	COG1070	Carbohydrate kinase
KHO74_RS07675	COG1438	arginine binding
KHO74_RS07685	COG0137	argininosuccinate synthase activity
KHO74_RS07690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KHO74_RS07695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KHO74_RS07700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KHO74_RS07705	COG1396	sequence-specific DNA binding
KHO74_RS07705	COG1917	Cupin 2, conserved barrel domain protein
KHO74_RS07710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KHO74_RS07730	COG4771	TonB-dependent receptor
KHO74_RS07785	COG0471	metal ion transport
KHO74_RS07790	COG3292	Two component regulator propeller
KHO74_RS07790	COG2205	protein histidine kinase activity
KHO74_RS07790	COG0745	RESPONSE REGULATOR receiver
KHO74_RS07820	COG3328	transposase activity
KHO74_RS07825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KHO74_RS07840	COG0165	Argininosuccinate lyase
KHO74_RS07850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KHO74_RS07860	COG2890	protein-(glutamine-N5) methyltransferase activity
KHO74_RS07865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KHO74_RS07865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KHO74_RS07875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KHO74_RS07880	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KHO74_RS07900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KHO74_RS07910	COG0436	Aminotransferase
KHO74_RS07915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KHO74_RS07920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KHO74_RS07925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KHO74_RS07945	COG1181	Belongs to the D-alanine--D-alanine ligase family
KHO74_RS07950	COG0564	pseudouridine synthase activity
KHO74_RS07955	COG0515	serine threonine protein kinase
KHO74_RS07955	COG2815	serine threonine protein kinase
KHO74_RS07960	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KHO74_RS07965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KHO74_RS07970	COG1785	Belongs to the alkaline phosphatase family
KHO74_RS07980	COG0366	Alpha amylase catalytic
KHO74_RS07985	COG1082	Xylose isomerase domain protein TIM barrel
KHO74_RS07990	COG4206	TonB-dependent receptor
KHO74_RS07990	COG1629	transport
KHO74_RS07995	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KHO74_RS08010	COG0366	Alpha amylase catalytic
KHO74_RS08015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KHO74_RS08025	COG2003	Belongs to the UPF0758 family
KHO74_RS08030	COG0463	Glycosyl transferase, family 2
KHO74_RS08030	COG1216	Glycosyl transferase, family 2
KHO74_RS08035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KHO74_RS08040	COG0280	phosphate acetyltransferase
KHO74_RS08045	COG1380	Effector of murein hydrolase LrgA
KHO74_RS08050	COG1346	cytolysis
KHO74_RS08095	COG1629	transport
KHO74_RS08110	COG3292	Two component regulator propeller
KHO74_RS08110	COG2205	protein histidine kinase activity
KHO74_RS08110	COG0745	RESPONSE REGULATOR receiver
KHO74_RS08115	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHO74_RS08145	COG1082	Xylose isomerase domain protein TIM barrel
KHO74_RS08150	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO74_RS08175	COG4948	Mandelate Racemase Muconate Lactonizing
KHO74_RS08185	COG1501	Belongs to the glycosyl hydrolase 31 family
KHO74_RS08195	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO74_RS08225	COG1704	LemA family
KHO74_RS08230	COG0312	modulator of DNA gyrase
KHO74_RS08235	COG0312	modulator of DNA gyrase
KHO74_RS08240	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KHO74_RS08245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KHO74_RS08250	COG5002	protein histidine kinase activity
KHO74_RS08250	COG0784	Response regulator, receiver
KHO74_RS08255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KHO74_RS08265	COG0733	neurotransmitter:sodium symporter activity
KHO74_RS08275	COG1136	(ABC) transporter
KHO74_RS08280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KHO74_RS08285	COG0589	response to stress
KHO74_RS08285	COG0475	glutathione-regulated potassium exporter activity
KHO74_RS08295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KHO74_RS08305	COG0463	Glycosyl transferase, family 2
KHO74_RS08305	COG1216	Glycosyl transferase, family 2
KHO74_RS08310	COG0562	UDP-galactopyranose mutase
KHO74_RS08365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS08440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KHO74_RS08445	COG1215	transferase activity, transferring glycosyl groups
KHO74_RS08450	COG2385	sporulation resulting in formation of a cellular spore
KHO74_RS08450	COG2247	cell wall binding repeat
KHO74_RS08455	COG2211	Major facilitator Superfamily
KHO74_RS08470	COG1063	alcohol dehydrogenase
KHO74_RS08475	COG0738	Major facilitator superfamily
KHO74_RS08490	COG1609	Transcriptional regulator
KHO74_RS08500	COG0423	glycine-tRNA ligase activity
KHO74_RS08510	COG1609	Transcriptional regulator
KHO74_RS08510	COG2207	Transcriptional regulator
KHO74_RS08515	COG3458	cephalosporin-C deacetylase activity
KHO74_RS08525	COG2814	Major facilitator Superfamily
KHO74_RS08535	COG4771	TonB-dependent receptor
KHO74_RS08550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KHO74_RS08550	COG0517	IMP dehydrogenase activity
KHO74_RS08565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS08595	COG3345	alpha-galactosidase
KHO74_RS08615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KHO74_RS08620	COG0363	glucosamine-6-phosphate deaminase activity
KHO74_RS08640	COG0673	inositol 2-dehydrogenase activity
KHO74_RS08645	COG0673	inositol 2-dehydrogenase activity
KHO74_RS08700	COG4771	TonB-dependent receptor
KHO74_RS08710	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO74_RS08775	COG2954	triphosphatase activity
KHO74_RS08995	COG0517	IMP dehydrogenase activity
KHO74_RS09010	COG0517	IMP dehydrogenase activity
KHO74_RS09015	COG0517	IMP dehydrogenase activity
KHO74_RS09020	COG4974	Belongs to the 'phage' integrase family
KHO74_RS09035	COG0551	DNA topoisomerase type I activity
KHO74_RS09035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KHO74_RS09050	COG4804	nuclease activity
KHO74_RS09085	COG0612	Peptidase, M16
KHO74_RS09090	COG1022	Amp-dependent synthetase and ligase
KHO74_RS09095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KHO74_RS09100	COG1373	ATPase (AAA superfamily
KHO74_RS09160	COG2017	converts alpha-aldose to the beta-anomer
KHO74_RS09170	COG3537	Alpha-1,2-mannosidase
KHO74_RS09185	COG3537	Alpha-1,2-mannosidase
KHO74_RS09220	COG0561	phosphatase activity
KHO74_RS09225	COG1629	transport
KHO74_RS09255	COG3250	beta-galactosidase activity
KHO74_RS09290	COG0702	epimerase
KHO74_RS09295	COG4771	TonB-dependent receptor
KHO74_RS09335	COG4771	TonB-dependent receptor
KHO74_RS09340	COG0702	epimerase
KHO74_RS09385	COG1629	transport
KHO74_RS09400	COG3119	arylsulfatase activity
KHO74_RS09430	COG4771	TonB-dependent receptor
KHO74_RS09450	COG3292	Two component regulator propeller
KHO74_RS09450	COG2205	protein histidine kinase activity
KHO74_RS09450	COG0745	RESPONSE REGULATOR receiver
KHO74_RS09455	COG4942	peptidase
KHO74_RS09470	COG0756	dUTP diphosphatase activity
KHO74_RS09475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KHO74_RS09490	COG1595	DNA-templated transcription, initiation
KHO74_RS09495	COG2001	Belongs to the MraZ family
KHO74_RS09500	COG0275	rRNA processing
KHO74_RS09515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KHO74_RS09520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KHO74_RS09525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KHO74_RS09530	COG0772	Belongs to the SEDS family
KHO74_RS09535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KHO74_RS09540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KHO74_RS09555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KHO74_RS09560	COG1610	YqeY-like protein
KHO74_RS09585	COG2433	Pfam Transposase IS66
KHO74_RS09630	COG1381	Involved in DNA repair and RecF pathway recombination
KHO74_RS09680	COG0268	Binds directly to 16S ribosomal RNA
KHO74_RS09685	COG0187	DNA topoisomerase II activity
KHO74_RS09700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KHO74_RS09720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KHO74_RS09725	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KHO74_RS09735	COG0393	Putative heavy-metal-binding
KHO74_RS09740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KHO74_RS09745	COG0719	Fe-S assembly protein
KHO74_RS09750	COG0396	ATPase activity
KHO74_RS09755	COG0719	Fe-S assembly protein
KHO74_RS09765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KHO74_RS09770	COG0195	Participates in both transcription termination and antitermination
KHO74_RS09775	COG0779	Required for maturation of 30S ribosomal subunits
KHO74_RS09800	COG1595	DNA-templated transcription, initiation
KHO74_RS09805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KHO74_RS09810	COG1166	arginine decarboxylase activity
KHO74_RS09815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KHO74_RS09825	COG0328	RNA-DNA hybrid ribonuclease activity
KHO74_RS09825	COG3341	Caulimovirus viroplasmin
KHO74_RS09850	COG1132	(ABC) transporter
KHO74_RS09880	COG0463	Glycosyl transferase, family 2
KHO74_RS09900	COG0436	Aminotransferase
KHO74_RS09905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KHO74_RS09930	COG1215	transferase activity, transferring glycosyl groups
KHO74_RS09955	COG1216	Glycosyl transferase, family 2
KHO74_RS09955	COG1442	glycosyl transferase family 8
KHO74_RS09985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KHO74_RS09995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KHO74_RS10000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KHO74_RS10005	COG0571	ribonuclease III activity
KHO74_RS10010	COG0205	6-phosphofructokinase activity
KHO74_RS10020	COG0482	sulfurtransferase activity
KHO74_RS10025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KHO74_RS10030	COG0561	phosphatase activity
KHO74_RS10075	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS10100	COG0215	cysteine-tRNA ligase activity
KHO74_RS10105	COG5492	domain, Protein
KHO74_RS10110	COG3119	arylsulfatase activity
KHO74_RS10115	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KHO74_RS10125	COG4771	TonB-dependent receptor
KHO74_RS10130	COG0702	epimerase
KHO74_RS10155	COG3250	beta-galactosidase activity
KHO74_RS10160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS10170	COG1538	Outer membrane efflux protein
KHO74_RS10175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KHO74_RS10185	COG0745	RESPONSE REGULATOR receiver
KHO74_RS10185	COG2205	protein histidine kinase activity
KHO74_RS10185	COG3292	Two component regulator propeller
KHO74_RS10185	COG2205	protein histidine kinase activity
KHO74_RS10185	COG3292	Two component regulator propeller
KHO74_RS10185	COG0745	RESPONSE REGULATOR receiver
KHO74_RS10190	COG3119	arylsulfatase activity
KHO74_RS10195	COG4771	TonB-dependent receptor
KHO74_RS10200	COG0702	epimerase
KHO74_RS10220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KHO74_RS10240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KHO74_RS10290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KHO74_RS10300	COG0681	Belongs to the peptidase S26 family
KHO74_RS10315	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO74_RS10330	COG0702	epimerase
KHO74_RS10335	COG4771	TonB-dependent receptor
KHO74_RS10345	COG0612	Peptidase, M16
KHO74_RS10370	COG0513	Belongs to the DEAD box helicase family
KHO74_RS10375	COG2205	protein histidine kinase activity
KHO74_RS10375	COG0745	RESPONSE REGULATOR receiver
KHO74_RS10375	COG3292	Two component regulator propeller
KHO74_RS10395	COG4771	TonB-dependent receptor
KHO74_RS10400	COG0702	epimerase
KHO74_RS10420	COG4948	Mandelate Racemase Muconate Lactonizing
KHO74_RS10425	COG3250	beta-galactosidase activity
KHO74_RS10430	COG3250	beta-galactosidase activity
KHO74_RS10445	COG3591	Belongs to the peptidase S1B family
KHO74_RS10465	COG2255	four-way junction helicase activity
KHO74_RS10470	COG0700	Nucleoside recognition
KHO74_RS10475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KHO74_RS10495	COG4206	TonB-dependent receptor
KHO74_RS10495	COG1629	transport
KHO74_RS10505	COG2197	response regulator
KHO74_RS10535	COG4771	TonB-dependent receptor
KHO74_RS10550	COG0445	tRNA wobble uridine modification
KHO74_RS10555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KHO74_RS10560	COG0322	excinuclease ABC activity
KHO74_RS10565	COG1490	D-aminoacyl-tRNA deacylase activity
KHO74_RS10570	COG1694	Mazg nucleotide pyrophosphohydrolase
KHO74_RS10585	COG0142	geranyltranstransferase activity
KHO74_RS10590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KHO74_RS10590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KHO74_RS10600	COG3279	Response regulator of the LytR AlgR family
KHO74_RS10605	COG3275	phosphorelay sensor kinase activity
KHO74_RS10610	COG1045	serine acetyltransferase
KHO74_RS10615	COG0116	Belongs to the methyltransferase superfamily
KHO74_RS10615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KHO74_RS10620	COG0823	Involved in the tonB-independent uptake of proteins
KHO74_RS10620	COG1506	peptidase
KHO74_RS10635	COG1238	metal cluster binding
KHO74_RS10640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KHO74_RS10640	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KHO74_RS10650	COG1121	(ABC) transporter
KHO74_RS10665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KHO74_RS10695	COG1629	transport
KHO74_RS10695	COG4206	TonB-dependent receptor
KHO74_RS10730	COG1028	Short-chain dehydrogenase reductase Sdr
KHO74_RS10735	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KHO74_RS10745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KHO74_RS10755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KHO74_RS10760	COG0594	ribonuclease P activity
KHO74_RS10810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KHO74_RS10825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KHO74_RS10835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KHO74_RS10840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KHO74_RS10845	COG1968	undecaprenyl-diphosphatase activity
KHO74_RS10855	COG2177	Part of the ABC transporter FtsEX involved in
KHO74_RS10905	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS10930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KHO74_RS10940	COG0427	acetyl-CoA hydrolase
KHO74_RS11045	COG0358	DNA primase activity
KHO74_RS11150	COG0519	Catalyzes the synthesis of GMP from XMP
KHO74_RS11175	COG2198	Histidine kinase
KHO74_RS11175	COG0784	Response regulator, receiver
KHO74_RS11175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHO74_RS11175	COG2205	protein histidine kinase activity
KHO74_RS11195	COG0551	DNA topoisomerase type I activity
KHO74_RS11195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KHO74_RS11235	COG1204	response to ionizing radiation
KHO74_RS11245	COG4974	Belongs to the 'phage' integrase family
KHO74_RS11260	COG1592	Rubrerythrin
KHO74_RS11265	COG0659	secondary active sulfate transmembrane transporter activity
KHO74_RS11275	COG3250	beta-galactosidase activity
KHO74_RS11280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS11285	COG3119	arylsulfatase activity
KHO74_RS11310	COG2205	protein histidine kinase activity
KHO74_RS11310	COG0745	RESPONSE REGULATOR receiver
KHO74_RS11310	COG2205	protein histidine kinase activity
KHO74_RS11310	COG3292	Two component regulator propeller
KHO74_RS11310	COG0745	RESPONSE REGULATOR receiver
KHO74_RS11310	COG3292	Two component regulator propeller
KHO74_RS11335	COG0731	radical SAM domain protein
KHO74_RS11335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KHO74_RS11355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KHO74_RS11360	COG4948	Mandelate Racemase Muconate Lactonizing
KHO74_RS11365	COG0584	glycerophosphoryl diester phosphodiesterase
KHO74_RS11375	COG5434	Belongs to the glycosyl hydrolase 28 family
KHO74_RS11395	COG1629	transport
KHO74_RS11405	COG3292	Two component regulator propeller
KHO74_RS11405	COG2205	protein histidine kinase activity
KHO74_RS11405	COG0745	RESPONSE REGULATOR receiver
KHO74_RS11405	COG3292	Two component regulator propeller
KHO74_RS11405	COG0745	RESPONSE REGULATOR receiver
KHO74_RS11405	COG2205	protein histidine kinase activity
KHO74_RS11425	COG3537	Alpha-1,2-mannosidase
KHO74_RS11430	COG1360	Flagellar Motor Protein
KHO74_RS11435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KHO74_RS11440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KHO74_RS11445	COG0495	leucyl-tRNA aminoacylation
KHO74_RS11455	COG0697	spore germination
KHO74_RS11460	COG2207	Transcriptional regulator
KHO74_RS11460	COG0662	Cupin 2, conserved barrel domain protein
KHO74_RS11465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHO74_RS11480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KHO74_RS11485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KHO74_RS11490	COG0012	GTP binding
KHO74_RS11495	COG1012	belongs to the aldehyde dehydrogenase family
KHO74_RS11505	COG2814	Major facilitator Superfamily
KHO74_RS11510	COG1073	alpha beta
KHO74_RS11525	COG3119	arylsulfatase activity
KHO74_RS11550	COG4771	TonB-dependent receptor
KHO74_RS11560	COG3119	arylsulfatase activity
KHO74_RS11580	COG3292	Two component regulator propeller
KHO74_RS11580	COG0745	RESPONSE REGULATOR receiver
KHO74_RS11580	COG2205	protein histidine kinase activity
KHO74_RS11590	COG3119	arylsulfatase activity
KHO74_RS11590	COG3408	Glycogen debranching enzyme
KHO74_RS11615	COG4771	TonB-dependent receptor
KHO74_RS11620	COG0702	epimerase
KHO74_RS11640	COG1501	Belongs to the glycosyl hydrolase 31 family
KHO74_RS11655	COG1621	beta-fructofuranosidase activity
KHO74_RS11660	COG1917	Cupin 2, conserved barrel domain protein
KHO74_RS11670	COG4948	Mandelate Racemase Muconate Lactonizing
KHO74_RS11680	COG0561	phosphatase activity
KHO74_RS11685	COG4206	TonB-dependent receptor
KHO74_RS11685	COG1629	transport
KHO74_RS11705	COG0557	exoribonuclease II activity
KHO74_RS11720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KHO74_RS11725	COG0826	peptidase U32
KHO74_RS11735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KHO74_RS11735	COG0758	DNA mediated transformation
KHO74_RS11755	COG3345	alpha-galactosidase
KHO74_RS11790	COG3119	arylsulfatase activity
KHO74_RS11800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KHO74_RS11805	COG1053	succinate dehydrogenase
KHO74_RS11820	COG3119	arylsulfatase activity
KHO74_RS11830	COG0745	RESPONSE REGULATOR receiver
KHO74_RS11830	COG3292	Two component regulator propeller
KHO74_RS11830	COG2205	protein histidine kinase activity
KHO74_RS11845	COG1629	transport
KHO74_RS11895	COG0793	Belongs to the peptidase S41A family
KHO74_RS11895	COG3409	Peptidoglycan-binding domain 1 protein
KHO74_RS11900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KHO74_RS11920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KHO74_RS11925	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KHO74_RS11945	COG4771	TonB-dependent receptor
KHO74_RS11950	COG1373	ATPase (AAA superfamily
KHO74_RS11990	COG4206	TonB-dependent receptor
KHO74_RS11990	COG1629	transport
KHO74_RS12005	COG1501	Belongs to the glycosyl hydrolase 31 family
KHO74_RS12010	COG4206	TonB-dependent receptor
KHO74_RS12010	COG1629	transport
KHO74_RS12055	COG0561	phosphatase activity
KHO74_RS12060	COG1629	transport
KHO74_RS12075	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO74_RS12120	COG0545	Peptidyl-prolyl cis-trans isomerase
KHO74_RS12125	COG0545	Peptidyl-prolyl cis-trans isomerase
KHO74_RS12130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KHO74_RS12150	COG0745	RESPONSE REGULATOR receiver
KHO74_RS12150	COG2205	protein histidine kinase activity
KHO74_RS12150	COG3292	Two component regulator propeller
KHO74_RS12150	COG0745	RESPONSE REGULATOR receiver
KHO74_RS12150	COG2205	protein histidine kinase activity
KHO74_RS12150	COG3292	Two component regulator propeller
KHO74_RS12160	COG3250	beta-galactosidase activity
KHO74_RS12165	COG4771	TonB-dependent receptor
KHO74_RS12170	COG0702	epimerase
KHO74_RS12185	COG5492	domain, Protein
KHO74_RS12210	COG1216	Glycosyl transferase, family 2
KHO74_RS12215	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS12220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KHO74_RS12255	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS12265	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS12285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHO74_RS12285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHO74_RS12340	COG2205	protein histidine kinase activity
KHO74_RS12340	COG0745	RESPONSE REGULATOR receiver
KHO74_RS12340	COG3292	Two component regulator propeller
KHO74_RS12345	COG0673	inositol 2-dehydrogenase activity
KHO74_RS12355	COG0673	inositol 2-dehydrogenase activity
KHO74_RS12435	COG0702	epimerase
KHO74_RS12455	COG3250	beta-galactosidase activity
KHO74_RS12460	COG3634	alkyl hydroperoxide reductase activity
KHO74_RS12485	COG3250	beta-galactosidase activity
KHO74_RS12505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KHO74_RS12510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KHO74_RS12530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KHO74_RS12555	COG2244	polysaccharide biosynthetic process
KHO74_RS12585	COG3754	Rhamnan synthesis protein F
KHO74_RS12620	COG1215	transferase activity, transferring glycosyl groups
KHO74_RS12630	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS12635	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS12640	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS12650	COG3206	protein involved in exopolysaccharide biosynthesis
KHO74_RS12650	COG0489	protein tyrosine kinase activity
KHO74_RS12670	COG2205	protein histidine kinase activity
KHO74_RS12690	COG0606	chelatase, subunit chli
KHO74_RS12705	COG4974	Belongs to the 'phage' integrase family
KHO74_RS12725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KHO74_RS12730	COG4591	ABC-type transport system involved in lipoprotein release permease component
KHO74_RS12735	COG1013	pyruvate-flavodoxin oxidoreductase activity
KHO74_RS12740	COG0674	pyruvate-flavodoxin oxidoreductase activity
KHO74_RS12740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KHO74_RS12800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHO74_RS12805	COG3723	Recombinational DNA repair protein, rece pathway
KHO74_RS12870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KHO74_RS13130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KHO74_RS13135	COG0339	signal peptide processing
KHO74_RS13150	COG0705	Rhomboid family
KHO74_RS13160	COG0018	arginyl-trna synthetase
KHO74_RS13175	COG0745	RESPONSE REGULATOR receiver
KHO74_RS13175	COG2205	protein histidine kinase activity
KHO74_RS13175	COG0745	RESPONSE REGULATOR receiver
KHO74_RS13175	COG3292	Two component regulator propeller
KHO74_RS13175	COG2205	protein histidine kinase activity
KHO74_RS13175	COG3292	Two component regulator propeller
KHO74_RS13215	COG1629	transport
KHO74_RS13230	COG2816	NAD+ diphosphatase activity
KHO74_RS13235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KHO74_RS13240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KHO74_RS13250	COG3634	alkyl hydroperoxide reductase activity
KHO74_RS13280	COG4771	TonB-dependent receptor
KHO74_RS13285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KHO74_RS13290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KHO74_RS13300	COG0483	inositol monophosphate 1-phosphatase activity
KHO74_RS13320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KHO74_RS13325	COG0793	Belongs to the peptidase S41A family
KHO74_RS13330	COG2205	protein histidine kinase activity
KHO74_RS13330	COG3437	response regulator, receiver
KHO74_RS13330	COG3850	Histidine kinase
KHO74_RS13330	COG4999	Histidine kinase
KHO74_RS13335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KHO74_RS13365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KHO74_RS13370	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KHO74_RS13375	COG2059	Chromate
KHO74_RS13390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KHO74_RS13405	COG1396	sequence-specific DNA binding
KHO74_RS13410	COG0318	PFAM AMP-dependent synthetase and ligase
KHO74_RS13415	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KHO74_RS13415	COG0662	Cupin 2, conserved barrel domain protein
KHO74_RS13465	COG2096	Adenosyltransferase
KHO74_RS13500	COG0582	viral genome integration into host DNA
KHO74_RS13505	COG0535	radical SAM domain protein
KHO74_RS13535	COG0252	asparaginase activity
KHO74_RS13540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KHO74_RS13545	COG1027	Aspartate ammonia-lyase
KHO74_RS13575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KHO74_RS13585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KHO74_RS13595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KHO74_RS13610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KHO74_RS13615	COG0006	proline dipeptidase activity
KHO74_RS13620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KHO74_RS13625	COG4974	Belongs to the 'phage' integrase family
KHO74_RS13655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KHO74_RS13665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KHO74_RS13675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KHO74_RS13680	COG0081	regulation of translation
KHO74_RS13685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KHO74_RS13690	COG0222	ribosome binding
KHO74_RS13695	COG0085	RNA polymerase activity
KHO74_RS13700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KHO74_RS13710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KHO74_RS13715	COG0049	tRNA binding
KHO74_RS13720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KHO74_RS13725	COG0051	transcription antitermination factor activity, RNA binding
KHO74_RS13730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KHO74_RS13735	COG0088	Forms part of the polypeptide exit tunnel
KHO74_RS13740	COG0089	rRNA binding
KHO74_RS13745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KHO74_RS13750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KHO74_RS13755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KHO74_RS13760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KHO74_RS13765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KHO74_RS13770	COG0255	Belongs to the universal ribosomal protein uL29 family
KHO74_RS13775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KHO74_RS13780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KHO74_RS13785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KHO74_RS13790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KHO74_RS13795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KHO74_RS13800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KHO74_RS13805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KHO74_RS13810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KHO74_RS13815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KHO74_RS13820	COG1841	ribosomal large subunit assembly
KHO74_RS13825	COG0200	Binds to the 23S rRNA
KHO74_RS13840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KHO74_RS13845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KHO74_RS13850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KHO74_RS13855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KHO74_RS13860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KHO74_RS13865	COG0202	RNA polymerase activity
KHO74_RS13870	COG0203	ribosomal protein L17
KHO74_RS13885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHO74_RS13895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KHO74_RS13905	COG1228	amidohydrolase
KHO74_RS13915	COG2986	histidine ammonia-lyase
KHO74_RS13920	COG1309	transcriptional regulator
KHO74_RS13930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS13960	COG3250	beta-galactosidase activity
KHO74_RS13965	COG0667	Aldo Keto reductase
KHO74_RS14115	COG0531	amino acid
KHO74_RS14125	COG2066	Belongs to the glutaminase family
KHO74_RS14130	COG0076	glutamate decarboxylase activity
KHO74_RS14135	COG1595	DNA-templated transcription, initiation
KHO74_RS14155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KHO74_RS14165	COG1185	polyribonucleotide nucleotidyltransferase activity
KHO74_RS14180	COG4206	TonB-dependent receptor
KHO74_RS14180	COG1629	transport
KHO74_RS14205	COG3426	butyrate kinase activity
KHO74_RS14210	COG0280	phosphate acetyltransferase
KHO74_RS14220	COG1619	proteins homologs of microcin C7 resistance protein MccF
KHO74_RS14225	COG2234	aminopeptidase activity
KHO74_RS14230	COG2166	iron-sulfur cluster assembly
KHO74_RS14235	COG3655	Transcriptional regulator
KHO74_RS14245	COG1266	CAAX protease self-immunity
KHO74_RS14250	COG0196	riboflavin kinase activity
KHO74_RS14255	COG1011	Hydrolase
KHO74_RS14260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KHO74_RS14270	COG1773	rubredoxin
KHO74_RS14305	COG4206	TonB-dependent receptor
KHO74_RS14305	COG1629	transport
KHO74_RS14320	COG1283	sodium-dependent phosphate transmembrane transporter activity
KHO74_RS14335	COG3458	cephalosporin-C deacetylase activity
KHO74_RS14340	COG3408	Glycogen debranching enzyme
KHO74_RS14350	COG0006	proline dipeptidase activity
KHO74_RS14365	COG0509	glycine decarboxylation via glycine cleavage system
KHO74_RS14370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KHO74_RS14375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KHO74_RS14390	COG2217	Heavy metal translocating P-type atpase
KHO74_RS14400	COG0039	L-malate dehydrogenase activity
KHO74_RS14425	COG1629	transport
KHO74_RS14435	COG2996	Protein conserved in bacteria
KHO74_RS14455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KHO74_RS14465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KHO74_RS14465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KHO74_RS14475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS14480	COG1136	(ABC) transporter
KHO74_RS14480	COG0577	efflux transmembrane transporter activity
KHO74_RS14485	COG1136	(ABC) transporter
KHO74_RS14485	COG0577	efflux transmembrane transporter activity
KHO74_RS14490	COG1136	(ABC) transporter
KHO74_RS14490	COG0577	efflux transmembrane transporter activity
KHO74_RS14495	COG1940	carbohydrate kinase activity
KHO74_RS14510	COG0335	large ribosomal subunit rRNA binding
KHO74_RS14545	COG0737	Belongs to the 5'-nucleotidase family
KHO74_RS14550	COG0737	Belongs to the 5'-nucleotidase family
KHO74_RS14555	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO74_RS14580	COG0446	pyridine nucleotide-disulphide oxidoreductase
KHO74_RS14585	COG2204	response regulator
KHO74_RS14590	COG3250	beta-galactosidase activity
KHO74_RS14650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHO74_RS14655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KHO74_RS14660	COG1160	GTP binding
KHO74_RS14670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KHO74_RS14675	COG1127	ABC transporter
KHO74_RS14680	COG0724	RNA recognition motif
KHO74_RS14685	COG0544	peptidyl-prolyl cis-trans isomerase activity
KHO74_RS14690	COG0740	serine-type endopeptidase activity
KHO74_RS14695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KHO74_RS14700	COG0514	ATP-dependent DNA helicase (RecQ)
KHO74_RS14705	COG0516	GMP reductase activity
KHO74_RS14705	COG0517	IMP dehydrogenase activity
KHO74_RS14710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KHO74_RS14720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KHO74_RS14735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KHO74_RS14740	COG2885	chlorophyll binding
KHO74_RS14750	COG4771	TonB-dependent receptor
KHO74_RS14770	COG3537	Alpha-1,2-mannosidase
KHO74_RS14805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KHO74_RS14810	COG5433	transposase activity
KHO74_RS14820	COG3022	response to hydroperoxide
KHO74_RS14825	COG0110	maltose O-acetyltransferase activity
KHO74_RS14845	COG1187	pseudouridine synthase activity
KHO74_RS14850	COG0017	Asparaginyl-tRNA synthetase
KHO74_RS14860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KHO74_RS14865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KHO74_RS14870	COG0052	Belongs to the universal ribosomal protein uS2 family
KHO74_RS14875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KHO74_RS14890	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KHO74_RS14895	COG0179	Fumarylacetoacetate (FAA) hydrolase
KHO74_RS14900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KHO74_RS14915	COG0482	sulfurtransferase activity
KHO74_RS14925	COG1570	exodeoxyribonuclease VII activity
KHO74_RS14935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KHO74_RS14945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KHO74_RS14950	COG0489	protein tyrosine kinase activity
KHO74_RS14955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KHO74_RS14985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS15005	COG0714	Associated with various cellular activities
KHO74_RS15010	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KHO74_RS15015	COG3552	Protein containing von Willebrand factor type A (VWA) domain
KHO74_RS15020	COG0039	L-malate dehydrogenase activity
KHO74_RS15055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KHO74_RS15060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KHO74_RS15065	COG0811	peptide transport
KHO74_RS15070	COG0848	biopolymer transport protein
KHO74_RS15085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KHO74_RS15090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KHO74_RS15095	COG0105	UTP biosynthetic process
KHO74_RS15100	COG0739	heme binding
KHO74_RS15115	COG0149	triose-phosphate isomerase activity
KHO74_RS15125	COG0302	gtp cyclohydrolase
KHO74_RS15130	COG0358	DNA primase activity
KHO74_RS15140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KHO74_RS15145	COG0436	Aminotransferase
KHO74_RS15160	COG0514	ATP-dependent DNA helicase (RecQ)
KHO74_RS15165	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KHO74_RS15165	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KHO74_RS15180	COG0009	L-threonylcarbamoyladenylate synthase
KHO74_RS15190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KHO74_RS15195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KHO74_RS15200	COG2333	competence protein COMEC
KHO74_RS15200	COG0658	competence protein
KHO74_RS15205	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KHO74_RS15215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KHO74_RS15225	COG4771	TonB-dependent receptor
KHO74_RS15230	COG0561	phosphatase activity
KHO74_RS15250	COG0745	RESPONSE REGULATOR receiver
KHO74_RS15250	COG3292	Two component regulator propeller
KHO74_RS15250	COG2205	protein histidine kinase activity
KHO74_RS15255	COG4771	TonB-dependent receptor
KHO74_RS15275	COG3537	Alpha-1,2-mannosidase
KHO74_RS15280	COG3537	Alpha-1,2-mannosidase
KHO74_RS15290	COG3537	Alpha-1,2-mannosidase
KHO74_RS15295	COG3279	Response regulator of the LytR AlgR family
KHO74_RS15300	COG3275	phosphorelay sensor kinase activity
KHO74_RS15305	COG1566	PFAM secretion protein HlyD family protein
KHO74_RS15320	COG0386	Belongs to the glutathione peroxidase family
KHO74_RS15325	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KHO74_RS15330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KHO74_RS15370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KHO74_RS15465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KHO74_RS15480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KHO74_RS15485	COG0742	ribosomal rna small subunit methyltransferase
KHO74_RS15500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHO74_RS15505	COG4771	TonB-dependent receptor
KHO74_RS15540	COG3537	Alpha-1,2-mannosidase
KHO74_RS15545	COG3537	Alpha-1,2-mannosidase
KHO74_RS15565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KHO74_RS15570	COG0739	heme binding
KHO74_RS15580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KHO74_RS15585	COG1388	LysM domain
KHO74_RS15585	COG0741	lytic transglycosylase activity
KHO74_RS15595	COG1475	DNA binding
KHO74_RS15600	COG1192	Involved in chromosome partitioning
KHO74_RS15605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KHO74_RS15610	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KHO74_RS15620	COG4589	Belongs to the CDS family
KHO74_RS15625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KHO74_RS15630	COG0799	negative regulation of ribosome biogenesis
KHO74_RS15640	COG0702	epimerase
KHO74_RS15645	COG4206	TonB-dependent receptor
KHO74_RS15645	COG1629	transport
KHO74_RS15650	COG3291	Pkd domain containing protein
KHO74_RS15650	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS15655	COG1196	nuclear chromosome segregation
KHO74_RS15660	COG2239	Acts as a magnesium transporter
KHO74_RS15665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KHO74_RS15675	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHO74_RS15710	COG1119	ATPase activity
KHO74_RS15720	COG0668	transmembrane transport
KHO74_RS15725	COG2207	Transcriptional regulator
KHO74_RS15725	COG0662	Cupin 2, conserved barrel domain protein
KHO74_RS15750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHO74_RS15755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KHO74_RS15760	COG0713	ATP synthesis coupled electron transport
KHO74_RS15775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KHO74_RS15780	COG0649	NAD binding
KHO74_RS15780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHO74_RS15785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHO74_RS15790	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHO74_RS15825	COG3250	beta-galactosidase activity
KHO74_RS15835	COG3408	Glycogen debranching enzyme
KHO74_RS15840	COG3250	beta-galactosidase activity
KHO74_RS15845	COG3940	Belongs to the glycosyl hydrolase 43 family
KHO74_RS15855	COG0702	epimerase
KHO74_RS15870	COG4771	TonB-dependent receptor
KHO74_RS15875	COG0702	epimerase
KHO74_RS15880	COG1629	transport
KHO74_RS15880	COG4206	TonB-dependent receptor
KHO74_RS15900	COG3537	Alpha-1,2-mannosidase
KHO74_RS15910	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO74_RS15920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KHO74_RS15925	COG0569	domain protein
KHO74_RS15930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KHO74_RS15940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KHO74_RS15945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KHO74_RS15950	COG0805	protein transport
KHO74_RS15960	COG2271	Major facilitator Superfamily
KHO74_RS15965	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KHO74_RS15970	COG3775	system Galactitol-specific IIC component
KHO74_RS15985	COG2755	lipolytic protein G-D-S-L family
KHO74_RS15990	COG3292	Two component regulator propeller
KHO74_RS15990	COG0745	RESPONSE REGULATOR receiver
KHO74_RS15990	COG2205	protein histidine kinase activity
KHO74_RS16000	COG0702	epimerase
KHO74_RS16005	COG4771	TonB-dependent receptor
KHO74_RS16025	COG3279	Response regulator of the LytR AlgR family
KHO74_RS16040	COG1629	transport
KHO74_RS16040	COG4206	TonB-dependent receptor
KHO74_RS16055	COG3292	Two component regulator propeller
KHO74_RS16055	COG0745	RESPONSE REGULATOR receiver
KHO74_RS16055	COG2205	protein histidine kinase activity
KHO74_RS16060	COG1242	4 iron, 4 sulfur cluster binding
KHO74_RS16070	COG0363	glucosamine-6-phosphate deaminase activity
KHO74_RS16075	COG0009	L-threonylcarbamoyladenylate synthase
KHO74_RS16085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHO74_RS16090	COG0561	phosphatase activity
KHO74_RS16095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KHO74_RS16100	COG1408	metallophosphoesterase
KHO74_RS16130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KHO74_RS16150	COG3681	Belongs to the UPF0597 family
KHO74_RS16155	COG1047	Peptidyl-prolyl cis-trans
KHO74_RS16160	COG0129	dihydroxy-acid dehydratase activity
KHO74_RS16165	COG0028	Belongs to the TPP enzyme family
KHO74_RS16180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KHO74_RS16185	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KHO74_RS16190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KHO74_RS16195	COG0538	isocitrate dehydrogenase activity
KHO74_RS16200	COG0372	Belongs to the citrate synthase family
KHO74_RS16220	COG0205	6-phosphofructokinase activity
KHO74_RS16225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KHO74_RS16230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KHO74_RS16250	COG0084	hydrolase, TatD family'
KHO74_RS16260	COG0811	peptide transport
KHO74_RS16290	COG1522	sequence-specific DNA binding
KHO74_RS16300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KHO74_RS16315	COG1595	DNA-templated transcription, initiation
KHO74_RS16325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KHO74_RS16325	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KHO74_RS16355	COG0488	(ABC) transporter
KHO74_RS16360	COG0784	Response regulator, receiver
KHO74_RS16360	COG2205	protein histidine kinase activity
KHO74_RS16370	COG1629	transport
KHO74_RS16370	COG4206	TonB-dependent receptor
KHO74_RS16375	COG4771	TonB-dependent receptor
KHO74_RS16395	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS16425	COG2205	protein histidine kinase activity
KHO74_RS16445	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KHO74_RS16455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KHO74_RS16460	COG1088	dTDP-glucose 4,6-dehydratase activity
KHO74_RS16465	COG1575	Belongs to the MenA family. Type 1 subfamily
KHO74_RS16470	COG1408	metallophosphoesterase
KHO74_RS16475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KHO74_RS16485	COG0194	GDP metabolic process
KHO74_RS16505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KHO74_RS16510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KHO74_RS16520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KHO74_RS16525	COG0750	zinc metalloprotease
KHO74_RS16530	COG2814	Major facilitator Superfamily
KHO74_RS16535	COG0602	queuosine metabolic process
KHO74_RS16540	COG1328	CTP reductase activity
KHO74_RS16540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KHO74_RS16550	COG3328	transposase activity
KHO74_RS16580	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS16605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KHO74_RS16620	COG1272	protein, Hemolysin III
KHO74_RS16635	COG0673	inositol 2-dehydrogenase activity
KHO74_RS16640	COG0632	four-way junction helicase activity
KHO74_RS16660	COG0617	tRNA 3'-terminal CCA addition
KHO74_RS16665	COG0024	Methionine aminopeptidase
KHO74_RS16685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KHO74_RS16715	COG1538	Outer membrane efflux protein
KHO74_RS16770	COG2873	o-acetylhomoserine
KHO74_RS16780	COG2855	membrane
KHO74_RS16790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KHO74_RS16795	COG0511	ligase activity, forming carbon-carbon bonds
KHO74_RS16795	COG5016	pyruvate
KHO74_RS16800	COG0439	Biotin carboxylase
KHO74_RS16810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KHO74_RS16820	COG1028	Short-chain dehydrogenase reductase Sdr
KHO74_RS16845	COG1917	Cupin 2, conserved barrel domain protein
KHO74_RS16845	COG4977	sequence-specific DNA binding
KHO74_RS16855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KHO74_RS16865	COG0534	Mate efflux family protein
KHO74_RS16880	COG1704	LemA family
KHO74_RS16900	COG3973	AAA domain
KHO74_RS16915	COG0724	RNA recognition motif
KHO74_RS16920	COG2070	2-Nitropropane dioxygenase
KHO74_RS16925	COG0513	Belongs to the DEAD box helicase family
KHO74_RS16945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KHO74_RS16950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KHO74_RS16955	COG1663	tetraacyldisaccharide 4'-kinase activity
KHO74_RS16960	COG0616	signal peptide processing
KHO74_RS16980	COG4771	TonB-dependent receptor
KHO74_RS16985	COG0702	epimerase
KHO74_RS16990	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO74_RS17000	COG4948	Mandelate Racemase Muconate Lactonizing
KHO74_RS17035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KHO74_RS17040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KHO74_RS17045	COG0066	3-isopropylmalate dehydratase activity
KHO74_RS17055	COG0473	3-isopropylmalate dehydrogenase activity
KHO74_RS17070	COG0671	phosphoesterase, PA-phosphatase related
KHO74_RS17080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KHO74_RS17095	COG0514	ATP-dependent DNA helicase (RecQ)
KHO74_RS17120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KHO74_RS17135	COG0124	histidyl-tRNA synthetase
KHO74_RS17145	COG1506	peptidase
KHO74_RS17145	COG0823	Involved in the tonB-independent uptake of proteins
KHO74_RS17150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KHO74_RS17160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KHO74_RS17175	COG0784	Response regulator, receiver
KHO74_RS17175	COG5002	protein histidine kinase activity
KHO74_RS17175	COG2205	protein histidine kinase activity
KHO74_RS17190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KHO74_RS17195	COG0459	protein refolding
KHO74_RS17240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KHO74_RS17245	COG1120	ATPase activity
KHO74_RS17270	COG1192	Involved in chromosome partitioning
KHO74_RS17280	COG1629	transport
KHO74_RS17345	COG4974	Belongs to the 'phage' integrase family
KHO74_RS17350	COG4974	Belongs to the 'phage' integrase family
KHO74_RS17360	COG0717	Belongs to the dCTP deaminase family
KHO74_RS17370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KHO74_RS17380	COG2433	Pfam Transposase IS66
KHO74_RS17405	COG2885	chlorophyll binding
KHO74_RS17425	COG0028	Belongs to the TPP enzyme family
KHO74_RS17460	COG2194	sulfuric ester hydrolase activity
KHO74_RS17465	COG0484	heat shock protein binding
KHO74_RS17475	COG1956	GAF domain-containing protein
KHO74_RS17495	COG1960	acyl-CoA dehydrogenase activity
KHO74_RS17500	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KHO74_RS17515	COG2205	protein histidine kinase activity
KHO74_RS17550	COG3279	Response regulator of the LytR AlgR family
KHO74_RS17585	COG0475	glutathione-regulated potassium exporter activity
KHO74_RS17600	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO74_RS17610	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO74_RS17620	COG3250	beta-galactosidase activity
KHO74_RS17630	COG1629	transport
KHO74_RS17655	COG3537	Alpha-1,2-mannosidase
KHO74_RS17660	COG3250	beta-galactosidase activity
KHO74_RS17675	COG1621	beta-fructofuranosidase activity
KHO74_RS17685	COG1629	transport
KHO74_RS17685	COG4206	TonB-dependent receptor
KHO74_RS17690	COG0561	phosphatase activity
KHO74_RS17705	COG1621	beta-fructofuranosidase activity
KHO74_RS17715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KHO74_RS17715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KHO74_RS17725	COG0745	RESPONSE REGULATOR receiver
KHO74_RS17725	COG2205	protein histidine kinase activity
KHO74_RS17725	COG3292	Two component regulator propeller
KHO74_RS17745	COG4176	ABC-type proline glycine betaine transport system permease component
KHO74_RS17750	COG2113	Glycine betaine
KHO74_RS17775	COG1649	PFAM Uncharacterised BCR, COG1649
KHO74_RS17785	COG1966	Carbon starvation protein
KHO74_RS17810	COG1649	PFAM Uncharacterised BCR, COG1649
KHO74_RS17825	COG3292	Two component regulator propeller
KHO74_RS17825	COG2205	protein histidine kinase activity
KHO74_RS17825	COG0745	RESPONSE REGULATOR receiver
KHO74_RS17825	COG3292	Two component regulator propeller
KHO74_RS17825	COG2205	protein histidine kinase activity
KHO74_RS17825	COG0745	RESPONSE REGULATOR receiver
KHO74_RS17835	COG1280	lysine exporter protein (LysE YggA)
KHO74_RS17850	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KHO74_RS17890	COG4750	Nucleotidyl transferase
KHO74_RS17915	COG3475	LICD family
KHO74_RS17935	COG1215	transferase activity, transferring glycosyl groups
KHO74_RS17940	COG3475	LICD family
KHO74_RS18010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KHO74_RS18015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS18020	COG0254	rRNA binding
KHO74_RS18025	COG0191	fructose-bisphosphate aldolase activity
KHO74_RS18035	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KHO74_RS18040	COG0511	ligase activity, forming carbon-carbon bonds
KHO74_RS18050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KHO74_RS18065	COG4771	TonB-dependent receptor
KHO74_RS18075	COG0288	reversible hydration of carbon dioxide
KHO74_RS18085	COG0778	Nitroreductase
KHO74_RS18105	COG0424	maF-like protein
KHO74_RS18125	COG0126	phosphoglycerate kinase activity
KHO74_RS18130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KHO74_RS18135	COG2814	Major facilitator Superfamily
KHO74_RS18140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KHO74_RS18155	COG0560	Phosphoserine phosphatase
KHO74_RS18170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KHO74_RS18175	COG1523	belongs to the glycosyl hydrolase 13 family
KHO74_RS18180	COG1119	ATPase activity
KHO74_RS18185	COG2205	protein histidine kinase activity
KHO74_RS18185	COG0784	Response regulator, receiver
KHO74_RS18190	COG0588	phosphoglycerate mutase activity
KHO74_RS18195	COG1830	Aldolase
KHO74_RS18200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KHO74_RS18230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KHO74_RS18245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHO74_RS18260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KHO74_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
KHO74_RS18270	COG3959	Transketolase, thiamine diphosphate binding domain
KHO74_RS18275	COG3958	Transketolase
KHO74_RS18295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KHO74_RS18310	COG1091	dTDP-4-dehydrorhamnose reductase activity
KHO74_RS18320	COG2244	polysaccharide biosynthetic process
KHO74_RS18385	COG3119	arylsulfatase activity
KHO74_RS18390	COG3292	Two component regulator propeller
KHO74_RS18390	COG2205	protein histidine kinase activity
KHO74_RS18390	COG0745	RESPONSE REGULATOR receiver
KHO74_RS18390	COG3292	Two component regulator propeller
KHO74_RS18390	COG2205	protein histidine kinase activity
KHO74_RS18390	COG0745	RESPONSE REGULATOR receiver
KHO74_RS18395	COG1660	Displays ATPase and GTPase activities
KHO74_RS18400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KHO74_RS18410	COG1629	transport
KHO74_RS18410	COG4206	TonB-dependent receptor
KHO74_RS18415	COG0702	epimerase
KHO74_RS18425	COG3119	arylsulfatase activity
KHO74_RS18430	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS18435	COG3250	beta-galactosidase activity
KHO74_RS18445	COG3119	arylsulfatase activity
KHO74_RS18450	COG0668	transmembrane transport
KHO74_RS18455	COG3119	arylsulfatase activity
KHO74_RS18470	COG4206	TonB-dependent receptor
KHO74_RS18470	COG1629	transport
KHO74_RS18490	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHO74_RS18515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KHO74_RS18520	COG1983	PspC domain protein
KHO74_RS18535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KHO74_RS18540	COG1858	cytochrome C peroxidase
KHO74_RS18545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KHO74_RS18555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KHO74_RS18560	COG0534	Mate efflux family protein
KHO74_RS18565	COG2205	protein histidine kinase activity
KHO74_RS18565	COG2202	Pas domain
KHO74_RS18570	COG2205	protein histidine kinase activity
KHO74_RS18570	COG2202	Pas domain
KHO74_RS18575	COG3119	arylsulfatase activity
KHO74_RS18590	COG0037	tRNA processing
KHO74_RS18595	COG1918	ferrous iron import across plasma membrane
KHO74_RS18595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KHO74_RS18630	COG0456	acetyltransferase
KHO74_RS18685	COG0259	pyridoxamine-phosphate oxidase activity
KHO74_RS18690	COG1741	Belongs to the pirin family
KHO74_RS18695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KHO74_RS18710	COG1595	DNA-templated transcription, initiation
KHO74_RS18740	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KHO74_RS18750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KHO74_RS18760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KHO74_RS18805	COG0686	Belongs to the AlaDH PNT family
KHO74_RS18815	COG1629	transport
KHO74_RS18815	COG4206	TonB-dependent receptor
KHO74_RS18820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KHO74_RS18825	COG0739	heme binding
KHO74_RS18850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KHO74_RS18875	COG0488	(ABC) transporter
KHO74_RS18880	COG3250	beta-galactosidase activity
KHO74_RS18890	COG2205	protein histidine kinase activity
KHO74_RS18890	COG3292	Two component regulator propeller
KHO74_RS18890	COG0745	RESPONSE REGULATOR receiver
KHO74_RS18895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KHO74_RS18900	COG3059	membrane
KHO74_RS18915	COG1705	Flagellar rod assembly protein muramidase FlgJ
KHO74_RS18920	COG1252	NADH dehydrogenase
KHO74_RS18930	COG1136	(ABC) transporter
KHO74_RS18945	COG1136	(ABC) transporter
KHO74_RS18945	COG0577	efflux transmembrane transporter activity
KHO74_RS18950	COG0784	Response regulator, receiver
KHO74_RS18950	COG2205	protein histidine kinase activity
KHO74_RS18950	COG5002	protein histidine kinase activity
KHO74_RS18960	COG2204	response regulator
KHO74_RS18965	COG4191	Histidine kinase
KHO74_RS18980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KHO74_RS18990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KHO74_RS19010	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS19025	COG0305	Participates in initiation and elongation during chromosome replication
KHO74_RS19085	COG1475	DNA binding
KHO74_RS19175	COG1705	Flagellar rod assembly protein muramidase FlgJ
KHO74_RS19180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHO74_RS19250	COG0739	heme binding
KHO74_RS19270	COG0156	8-amino-7-oxononanoate synthase activity
KHO74_RS19280	COG1132	(ABC) transporter
KHO74_RS19375	COG3617	BRO family, N-terminal domain
KHO74_RS19500	COG2885	chlorophyll binding
KHO74_RS19515	COG2885	chlorophyll binding
KHO74_RS19520	COG1530	ribonuclease E activity
KHO74_RS19530	COG1194	a g-specific adenine glycosylase
KHO74_RS19535	COG0629	single-stranded DNA binding
KHO74_RS19560	COG3033	Beta-eliminating lyase
KHO74_RS19605	COG5002	protein histidine kinase activity
KHO74_RS19610	COG0745	RESPONSE REGULATOR receiver
KHO74_RS19625	COG0488	(ABC) transporter
KHO74_RS19640	COG0436	Aminotransferase
KHO74_RS19645	COG1136	(ABC) transporter
KHO74_RS19645	COG0577	efflux transmembrane transporter activity
KHO74_RS19650	COG0189	ligase activity
KHO74_RS19650	COG0569	domain protein
KHO74_RS19660	COG1215	transferase activity, transferring glycosyl groups
KHO74_RS19665	COG0628	permease
KHO74_RS19675	COG2204	response regulator
KHO74_RS19690	COG0577	efflux transmembrane transporter activity
KHO74_RS19690	COG1136	(ABC) transporter
KHO74_RS19695	COG0577	efflux transmembrane transporter activity
KHO74_RS19705	COG0110	maltose O-acetyltransferase activity
KHO74_RS19745	COG1690	Belongs to the RtcB family
KHO74_RS19750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KHO74_RS19755	COG1620	l-lactate permease
KHO74_RS19770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KHO74_RS19775	COG0439	Biotin carboxylase
KHO74_RS19780	COG0511	ligase activity, forming carbon-carbon bonds
KHO74_RS19785	COG0784	Response regulator, receiver
KHO74_RS19785	COG5002	protein histidine kinase activity
KHO74_RS19795	COG2226	methyltransferase
KHO74_RS19810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KHO74_RS19810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KHO74_RS19820	COG4771	TonB-dependent receptor
KHO74_RS19830	COG2223	nitrite transmembrane transporter activity
KHO74_RS19835	COG1929	Belongs to the glycerate kinase type-1 family
KHO74_RS19850	COG1609	Transcriptional regulator
KHO74_RS19855	COG1028	Short-chain dehydrogenase reductase Sdr
KHO74_RS19860	COG1312	Catalyzes the dehydration of D-mannonate
KHO74_RS19920	COG4771	TonB-dependent receptor
KHO74_RS19935	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KHO74_RS19945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KHO74_RS19960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KHO74_RS19965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KHO74_RS19975	COG1506	peptidase
KHO74_RS19975	COG0823	Involved in the tonB-independent uptake of proteins
KHO74_RS19975	COG4946	Tricorn protease homolog
KHO74_RS19980	COG3328	transposase activity
KHO74_RS19995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KHO74_RS20010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KHO74_RS20040	COG3546	catalase activity
KHO74_RS20070	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KHO74_RS20070	COG2885	chlorophyll binding
KHO74_RS20085	COG2076	Multidrug Resistance protein
KHO74_RS20090	COG0534	Mate efflux family protein
KHO74_RS20110	COG0656	L-ascorbic acid biosynthetic process
KHO74_RS20115	COG0693	protein deglycase activity
KHO74_RS20130	COG0788	formyltetrahydrofolate deformylase activity
KHO74_RS20135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KHO74_RS20140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KHO74_RS20145	COG0107	imidazoleglycerol-phosphate synthase activity
KHO74_RS20150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KHO74_RS20150	COG0140	phosphoribosyl-ATP diphosphatase activity
KHO74_RS20155	COG2884	Cell division ATP-binding protein ftsE
KHO74_RS20160	COG0527	aspartate kinase activity
KHO74_RS20165	COG0019	diaminopimelate decarboxylase activity
KHO74_RS20180	COG0156	8-amino-7-oxononanoate synthase activity
KHO74_RS20185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KHO74_RS20195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KHO74_RS20200	COG0321	lipoyl(octanoyl) transferase activity
KHO74_RS20200	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KHO74_RS20215	COG0592	DNA-directed DNA polymerase activity
KHO74_RS20230	COG0497	DNA recombination
KHO74_RS20235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHO74_RS20295	COG1442	glycosyl transferase family 8
KHO74_RS20295	COG1216	Glycosyl transferase, family 2
KHO74_RS20330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KHO74_RS20335	COG0167	dihydroorotate dehydrogenase activity
KHO74_RS20340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KHO74_RS20355	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KHO74_RS20365	COG0586	Pfam SNARE associated Golgi protein
KHO74_RS20375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KHO74_RS20385	COG0573	inorganic phosphate transmembrane transporter activity
KHO74_RS20390	COG0581	inorganic phosphate transmembrane transporter activity
KHO74_RS20395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KHO74_RS20400	COG0704	Plays a role in the regulation of phosphate uptake
KHO74_RS20430	COG0582	viral genome integration into host DNA
KHO74_RS20460	COG1295	ribonuclease BN
KHO74_RS20475	COG4948	Mandelate Racemase Muconate Lactonizing
KHO74_RS20480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KHO74_RS20485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KHO74_RS20545	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KHO74_RS20565	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KHO74_RS20575	COG0058	SHG alpha-glucan phosphorylase activity
KHO74_RS20580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KHO74_RS20585	COG3842	ATPase activity
KHO74_RS20590	COG1176	ABC-type spermidine putrescine transport system, permease component I
KHO74_RS20595	COG1177	transmembrane transport
KHO74_RS20615	COG2207	Transcriptional regulator
KHO74_RS20660	COG0738	Major facilitator superfamily
KHO74_RS20670	COG1070	Carbohydrate kinase
KHO74_RS20680	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
KHO74_RS20685	COG2188	Transcriptional regulator
KHO74_RS20690	COG0228	four-way junction DNA binding
KHO74_RS20715	COG3275	phosphorelay sensor kinase activity
KHO74_RS20725	COG2205	protein histidine kinase activity
KHO74_RS20725	COG2198	Histidine kinase
KHO74_RS20725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHO74_RS20725	COG0784	Response regulator, receiver
KHO74_RS20735	COG1733	regulation of RNA biosynthetic process
KHO74_RS20815	COG2721	sulfolactate sulfo-lyase activity
KHO74_RS20820	COG1609	Transcriptional regulator
KHO74_RS20860	COG4771	TonB-dependent receptor
KHO74_RS20875	COG1230	cation diffusion facilitator family transporter
KHO74_RS20880	COG0490	domain, Protein
KHO74_RS20880	COG2985	domain, Protein
KHO74_RS20890	COG4771	TonB-dependent receptor
KHO74_RS20900	COG4771	TonB-dependent receptor
KHO74_RS21060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHO74_RS21120	COG1196	nuclear chromosome segregation
KHO74_RS21120	COG0741	lytic transglycosylase activity
KHO74_RS21120	COG0739	heme binding
KHO74_RS21125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KHO74_RS21175	COG3344	reverse transcriptase
KHO74_RS21220	COG3209	COG3209 Rhs family protein
KHO74_RS21230	COG3209	COG3209 Rhs family protein
KHO74_RS21295	COG0542	response to heat
KHO74_RS21335	COG0629	single-stranded DNA binding
KHO74_RS21340	COG1192	Involved in chromosome partitioning
KHO74_RS21360	COG1475	DNA binding
KHO74_RS21510	COG4974	Belongs to the 'phage' integrase family
KHO74_RS21520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS21535	COG1132	(ABC) transporter
KHO74_RS21550	COG1333	cytochrome c biogenesis protein
KHO74_RS21550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KHO74_RS21565	COG3746	phosphate-selective porin O and P
KHO74_RS21575	COG3487	Iron-regulated protein
KHO74_RS21595	COG0716	FMN binding
KHO74_RS21605	COG0138	bifunctional purine biosynthesis protein purh
KHO74_RS21615	COG2197	response regulator
KHO74_RS21620	COG0110	maltose O-acetyltransferase activity
KHO74_RS21630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KHO74_RS21635	COG0745	RESPONSE REGULATOR receiver
KHO74_RS21635	COG2205	protein histidine kinase activity
KHO74_RS21635	COG3292	Two component regulator propeller
KHO74_RS21645	COG0252	asparaginase activity
KHO74_RS21650	COG0159	tryptophan synthase activity
KHO74_RS21655	COG0135	phosphoribosylanthranilate isomerase activity
KHO74_RS21660	COG0134	indole-3-glycerol-phosphate synthase activity
KHO74_RS21665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KHO74_RS21675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KHO74_RS21680	COG0133	tryptophan synthase activity
KHO74_RS21690	COG1979	alcohol dehydrogenase
KHO74_RS21700	COG0490	domain, Protein
KHO74_RS21700	COG0471	metal ion transport
KHO74_RS21705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KHO74_RS21725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KHO74_RS21740	COG0004	ammonium transporteR
KHO74_RS21745	COG0347	Belongs to the P(II) protein family
KHO74_RS21755	COG0436	Aminotransferase
KHO74_RS21760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KHO74_RS21775	COG0367	asparagine synthase
KHO74_RS21785	COG0070	glutamate synthase
KHO74_RS21785	COG0069	glutamate synthase activity
KHO74_RS21785	COG0067	glutamate synthase
KHO74_RS21790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KHO74_RS21800	COG0505	Belongs to the CarA family
KHO74_RS21805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KHO74_RS21815	COG1917	Cupin 2, conserved barrel domain protein
KHO74_RS21815	COG2207	Transcriptional regulator
KHO74_RS21830	COG1131	(ABC) transporter
KHO74_RS21835	COG0842	Transport permease protein
KHO74_RS21840	COG0842	Transport permease protein
KHO74_RS21850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KHO74_RS21855	COG2949	membrane
KHO74_RS21870	COG0556	nucleotide-excision repair
KHO74_RS21875	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KHO74_RS21905	COG1388	LysM domain
KHO74_RS21905	COG3942	CHAP domain
KHO74_RS21915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KHO74_RS21920	COG3104	oligopeptide transport
KHO74_RS21930	COG1695	Transcriptional regulator
KHO74_RS21935	COG1983	PspC domain protein
KHO74_RS21955	COG1506	peptidase
KHO74_RS21955	COG0823	Involved in the tonB-independent uptake of proteins
KHO74_RS21960	COG0534	Mate efflux family protein
KHO74_RS21965	COG0706	membrane insertase activity
KHO74_RS21970	COG0504	CTP synthase activity
KHO74_RS22025	COG1086	Polysaccharide biosynthesis protein
KHO74_RS22045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KHO74_RS22170	COG4656	Part of a membrane complex involved in electron transport
KHO74_RS22175	COG4658	electron transport chain
KHO74_RS22180	COG4659	FMN binding
KHO74_RS22185	COG4660	Part of a membrane complex involved in electron transport
KHO74_RS22190	COG4657	Part of a membrane complex involved in electron transport
KHO74_RS22195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KHO74_RS22200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KHO74_RS22205	COG0305	Participates in initiation and elongation during chromosome replication
KHO74_RS22210	COG0072	phenylalanine-tRNA ligase activity
KHO74_RS22210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHO74_RS22215	COG0217	transcriptional regulatory protein
KHO74_RS22230	COG0708	Exodeoxyribonuclease III
KHO74_RS22245	COG0481	GTPase activity
KHO74_RS22255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KHO74_RS22275	COG0024	Methionine aminopeptidase
KHO74_RS22295	COG0564	pseudouridine synthase activity
KHO74_RS22300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KHO74_RS22305	COG0574	Belongs to the PEP-utilizing enzyme family
KHO74_RS22305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KHO74_RS22320	COG0352	thiamine-phosphate diphosphorylase activity
KHO74_RS22325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KHO74_RS22330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KHO74_RS22335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KHO74_RS22340	COG2022	thiamine diphosphate biosynthetic process
KHO74_RS22345	COG0352	thiamine-phosphate diphosphorylase activity
KHO74_RS22355	COG3850	Histidine kinase
KHO74_RS22355	COG2205	protein histidine kinase activity
KHO74_RS22355	COG4999	Histidine kinase
KHO74_RS22355	COG3437	response regulator, receiver
KHO74_RS22370	COG0210	DNA helicase
KHO74_RS22425	COG0681	Belongs to the peptidase S26 family
KHO74_RS22435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS22455	COG2249	NAD(P)H dehydrogenase (quinone) activity
KHO74_RS22500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KHO74_RS22505	COG3118	belongs to the thioredoxin family
KHO74_RS22525	COG5002	protein histidine kinase activity
KHO74_RS22530	COG0745	RESPONSE REGULATOR receiver
KHO74_RS22535	COG1082	Xylose isomerase domain protein TIM barrel
KHO74_RS22540	COG0318	PFAM AMP-dependent synthetase and ligase
KHO74_RS22545	COG3263	regulation of cellular component size
KHO74_RS22550	COG2233	PERMEase
KHO74_RS22555	COG1151	hydroxylamine reductase activity
KHO74_RS22590	COG1136	(ABC) transporter
KHO74_RS22600	COG0534	Mate efflux family protein
KHO74_RS22610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KHO74_RS22620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KHO74_RS22640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KHO74_RS22655	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS22680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KHO74_RS22685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KHO74_RS22695	COG0356	it plays a direct role in the translocation of protons across the membrane
KHO74_RS22700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KHO74_RS22705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KHO74_RS22710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KHO74_RS22715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KHO74_RS22720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KHO74_RS22730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHO74_RS22735	COG2431	L-lysine efflux transmembrane transporter activity
KHO74_RS22760	COG2207	Transcriptional regulator
KHO74_RS22800	COG2985	domain, Protein
KHO74_RS22805	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KHO74_RS22810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KHO74_RS22825	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
KHO74_RS22830	COG0540	Belongs to the ATCase OTCase family
KHO74_RS22845	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KHO74_RS22860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KHO74_RS22865	COG2205	protein histidine kinase activity
KHO74_RS22890	COG1629	transport
KHO74_RS22890	COG4206	TonB-dependent receptor
KHO74_RS22900	COG3119	arylsulfatase activity
KHO74_RS22905	COG3250	beta-galactosidase activity
KHO74_RS22910	COG3153	acetyltransferase
KHO74_RS22960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KHO74_RS22965	COG1214	PFAM Peptidase M22, glycoprotease
KHO74_RS22965	COG0456	acetyltransferase
KHO74_RS22975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KHO74_RS22980	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KHO74_RS22985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KHO74_RS23000	COG0745	RESPONSE REGULATOR receiver
KHO74_RS23000	COG2205	protein histidine kinase activity
KHO74_RS23000	COG3292	Two component regulator propeller
KHO74_RS23030	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS23055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KHO74_RS23065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KHO74_RS23070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KHO74_RS23085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KHO74_RS23110	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
KHO74_RS23120	COG2326	polyphosphate kinase activity
KHO74_RS23155	COG3279	Response regulator of the LytR AlgR family
KHO74_RS23160	COG0724	RNA recognition motif
KHO74_RS23185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KHO74_RS23190	COG0045	succinate-CoA ligase (ADP-forming) activity
KHO74_RS23195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KHO74_RS23200	COG0351	phosphomethylpyrimidine kinase
KHO74_RS23215	COG2115	Belongs to the xylose isomerase family
KHO74_RS23220	COG2814	Major facilitator Superfamily
KHO74_RS23220	COG0477	Major facilitator Superfamily
KHO74_RS23225	COG3153	acetyltransferase
KHO74_RS23225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KHO74_RS23235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KHO74_RS23245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KHO74_RS23260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHO74_RS23290	COG3015	lipoprotein NlpE involved in copper resistance
KHO74_RS23295	COG2205	protein histidine kinase activity
KHO74_RS23295	COG2198	Histidine kinase
KHO74_RS23295	COG0784	Response regulator, receiver
KHO74_RS23315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KHO74_RS23330	COG4974	Belongs to the 'phage' integrase family
KHO74_RS23410	COG0587	DNA-directed DNA polymerase activity
KHO74_RS23415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHO74_RS23420	COG0587	DNA-directed DNA polymerase activity
KHO74_RS23645	COG0756	dUTP diphosphatase activity
KHO74_RS23650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KHO74_RS23690	COG0484	heat shock protein binding
KHO74_RS23985	COG1904	glucuronate isomerase
KHO74_RS23990	COG1609	Transcriptional regulator
KHO74_RS23995	COG0246	Mannitol dehydrogenase
KHO74_RS24025	COG0513	Belongs to the DEAD box helicase family
KHO74_RS24030	COG3830	Belongs to the UPF0237 family
KHO74_RS24030	COG0560	Phosphoserine phosphatase
KHO74_RS24050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KHO74_RS24055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KHO74_RS24070	COG2433	Pfam Transposase IS66
KHO74_RS24205	COG3328	transposase activity
KHO74_RS24230	COG0302	gtp cyclohydrolase
KHO74_RS24235	COG0602	queuosine metabolic process
KHO74_RS24300	COG0592	DNA-directed DNA polymerase activity
KHO74_RS24320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KHO74_RS24330	COG3852	Histidine kinase
KHO74_RS24355	COG1136	(ABC) transporter
KHO74_RS24390	COG4771	TonB-dependent receptor
KHO74_RS24405	COG0156	8-amino-7-oxononanoate synthase activity
KHO74_RS24410	COG1597	lipid kinase activity
KHO74_RS24415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KHO74_RS24445	COG1132	(ABC) transporter
KHO74_RS24465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KHO74_RS24495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KHO74_RS24510	COG0543	2 iron, 2 sulfur cluster binding
KHO74_RS24515	COG0167	dihydroorotate dehydrogenase activity
KHO74_RS24520	COG0336	Belongs to the RNA methyltransferase TrmD family
KHO74_RS24525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KHO74_RS24530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KHO74_RS24555	COG0326	Molecular chaperone. Has ATPase activity
KHO74_RS24605	COG2304	oxidoreductase activity
KHO74_RS24620	COG0714	Associated with various cellular activities
KHO74_RS24625	COG0776	regulation of translation
KHO74_RS24630	COG0776	regulation of translation
KHO74_RS24635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KHO74_RS24640	COG0552	protein localization to endoplasmic reticulum
KHO74_RS24650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KHO74_RS24655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KHO74_RS24665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KHO74_RS24700	COG2205	protein histidine kinase activity
KHO74_RS24705	COG0745	RESPONSE REGULATOR receiver
KHO74_RS24710	COG0442	prolyl-tRNA aminoacylation
KHO74_RS24725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS24740	COG0745	RESPONSE REGULATOR receiver
KHO74_RS24740	COG2205	protein histidine kinase activity
KHO74_RS24740	COG3292	Two component regulator propeller
KHO74_RS24785	COG1595	DNA-templated transcription, initiation
KHO74_RS24805	COG1011	Hydrolase
KHO74_RS24815	COG0300	oxidoreductase activity
KHO74_RS24820	COG4974	Belongs to the 'phage' integrase family
KHO74_RS24895	COG0739	heme binding
KHO74_RS24960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHO74_RS24960	COG2198	Histidine kinase
KHO74_RS24960	COG2205	protein histidine kinase activity
KHO74_RS24960	COG0784	Response regulator, receiver
KHO74_RS24970	COG0010	Belongs to the arginase family
KHO74_RS24975	COG0058	SHG alpha-glucan phosphorylase activity
KHO74_RS24980	COG4651	solute:proton antiporter activity
KHO74_RS24980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KHO74_RS24985	COG0205	6-phosphofructokinase activity
KHO74_RS25000	COG0588	phosphoglycerate mutase activity
KHO74_RS25005	COG1830	Aldolase
KHO74_RS25015	COG2095	MarC family integral membrane protein
KHO74_RS25055	COG3292	Two component regulator propeller
KHO74_RS25055	COG2205	protein histidine kinase activity
KHO74_RS25055	COG0745	RESPONSE REGULATOR receiver
KHO74_RS25060	COG1629	transport
KHO74_RS25065	COG0702	epimerase
KHO74_RS25110	COG2205	protein histidine kinase activity
KHO74_RS25110	COG0745	RESPONSE REGULATOR receiver
KHO74_RS25110	COG3292	Two component regulator propeller
KHO74_RS25110	COG2205	protein histidine kinase activity
KHO74_RS25110	COG0745	RESPONSE REGULATOR receiver
KHO74_RS25110	COG3292	Two component regulator propeller
KHO74_RS25245	COG3015	lipoprotein NlpE involved in copper resistance
KHO74_RS25295	COG0428	transporter
KHO74_RS25305	COG2375	cellular response to nickel ion
KHO74_RS25305	COG1132	(ABC) transporter
KHO74_RS25310	COG1132	(ABC) transporter
KHO74_RS25330	COG4771	TonB-dependent receptor
KHO74_RS25355	COG0622	Phosphoesterase
KHO74_RS25500	COG2433	Pfam Transposase IS66
KHO74_RS25525	COG2966	Psort location CytoplasmicMembrane, score
KHO74_RS25555	COG3292	Two component regulator propeller
KHO74_RS25555	COG0745	RESPONSE REGULATOR receiver
KHO74_RS25555	COG2205	protein histidine kinase activity
KHO74_RS25560	COG3250	beta-galactosidase activity
KHO74_RS25590	COG5002	protein histidine kinase activity
KHO74_RS25595	COG0745	RESPONSE REGULATOR receiver
KHO74_RS25600	COG3250	beta-galactosidase activity
KHO74_RS25620	COG3250	beta-galactosidase activity
KHO74_RS25680	COG2755	lipolytic protein G-D-S-L family
KHO74_RS25680	COG0657	acetylesterase activity
KHO74_RS25685	COG0167	dihydroorotate dehydrogenase activity
KHO74_RS25695	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KHO74_RS25705	COG3408	Glycogen debranching enzyme
KHO74_RS25715	COG1028	Short-chain dehydrogenase reductase Sdr
KHO74_RS25735	COG3408	Glycogen debranching enzyme
KHO74_RS25760	COG0702	epimerase
KHO74_RS25765	COG1629	transport
KHO74_RS25765	COG4206	TonB-dependent receptor
KHO74_RS25780	COG3537	Alpha-1,2-mannosidase
KHO74_RS25785	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KHO74_RS25820	COG1629	transport
KHO74_RS25820	COG4206	TonB-dependent receptor
KHO74_RS25825	COG4974	Belongs to the 'phage' integrase family
KHO74_RS25920	COG1475	DNA binding
KHO74_RS25930	COG2003	Belongs to the UPF0758 family
KHO74_RS26070	COG3344	reverse transcriptase
KHO74_RS26155	COG4974	Belongs to the 'phage' integrase family
KHO74_RS26165	COG0551	DNA topoisomerase type I activity
KHO74_RS26165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KHO74_RS26260	COG1629	transport
KHO74_RS26260	COG4206	TonB-dependent receptor
KHO74_RS26285	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS26305	COG1074	ATP-dependent DNA helicase activity
KHO74_RS26310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KHO74_RS26375	COG1475	DNA binding
KHO74_RS26380	COG3969	phosphoadenosine phosphosulfate
KHO74_RS26410	COG3275	phosphorelay sensor kinase activity
KHO74_RS26430	COG1678	Uncharacterized ACR, COG1678
KHO74_RS26445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KHO74_RS26455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KHO74_RS26485	COG0321	lipoyl(octanoyl) transferase activity
KHO74_RS26495	COG2217	Heavy metal translocating P-type atpase
KHO74_RS26540	COG0357	Ribosomal RNA small subunit methyltransferase G
KHO74_RS26545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KHO74_RS26550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KHO74_RS26550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KHO74_RS26555	COG0778	Nitroreductase
KHO74_RS26565	COG1739	Uncharacterized protein family UPF0029
KHO74_RS26580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KHO74_RS26585	COG0513	Belongs to the DEAD box helicase family
KHO74_RS26590	COG2871	sodium ion transport
KHO74_RS26595	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KHO74_RS26605	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KHO74_RS26610	COG1805	sodium ion transport
KHO74_RS26645	COG1215	transferase activity, transferring glycosyl groups
KHO74_RS26655	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS26695	COG1442	glycosyl transferase family 8
KHO74_RS26695	COG1216	Glycosyl transferase, family 2
KHO74_RS26700	COG2244	polysaccharide biosynthetic process
KHO74_RS26710	COG1442	glycosyl transferase family 8
KHO74_RS26715	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS26720	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS26725	COG1216	Glycosyl transferase, family 2
KHO74_RS26725	COG1442	glycosyl transferase family 8
KHO74_RS26755	COG0488	(ABC) transporter
KHO74_RS26775	COG1162	GTPase activity
KHO74_RS26785	COG2755	lipolytic protein G-D-S-L family
KHO74_RS26785	COG0657	acetylesterase activity
KHO74_RS26790	COG0534	Mate efflux family protein
KHO74_RS26795	COG2885	chlorophyll binding
KHO74_RS26800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KHO74_RS26815	COG1704	LemA family
KHO74_RS26820	COG0501	Belongs to the peptidase M48B family
KHO74_RS26845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KHO74_RS26855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KHO74_RS26880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO74_RS26885	COG1136	(ABC) transporter
KHO74_RS26890	COG1136	(ABC) transporter
KHO74_RS26890	COG0577	efflux transmembrane transporter activity
KHO74_RS26900	COG3279	Response regulator of the LytR AlgR family
KHO74_RS26905	COG2135	peptidase activity
KHO74_RS26910	COG2837	iron assimilation
KHO74_RS26920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KHO74_RS26930	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KHO74_RS26935	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KHO74_RS26940	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KHO74_RS26945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KHO74_RS26950	COG0318	PFAM AMP-dependent synthetase and ligase
KHO74_RS26960	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
KHO74_RS26965	COG2985	domain, Protein
KHO74_RS26965	COG0490	domain, Protein
KHO74_RS27005	COG0737	Belongs to the 5'-nucleotidase family
KHO74_RS27010	COG2205	protein histidine kinase activity
KHO74_RS27010	COG2202	Pas domain
KHO74_RS27015	COG2183	response to ionizing radiation
KHO74_RS27060	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO74_RS27085	COG0488	(ABC) transporter
KHO74_RS27090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KHO74_RS27095	COG0484	heat shock protein binding
KHO74_RS27100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KHO74_RS27105	COG4771	TonB-dependent receptor
KHO74_RS27130	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS27135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KHO74_RS27140	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS27155	COG0438	transferase activity, transferring glycosyl groups
KHO74_RS27165	COG1216	Glycosyl transferase, family 2
KHO74_RS27165	COG1442	glycosyl transferase family 8
KHO74_RS27200	COG3250	beta-galactosidase activity
KHO74_RS27205	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS27210	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS27220	COG2755	lipolytic protein G-D-S-L family
KHO74_RS27220	COG0657	acetylesterase activity
KHO74_RS27225	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO74_RS27250	COG1629	transport
KHO74_RS27340	COG0739	heme binding
KHO74_RS27340	COG0741	lytic transglycosylase activity
KHO74_RS27340	COG1196	nuclear chromosome segregation
KHO74_RS27410	COG1192	Involved in chromosome partitioning
KHO74_RS27425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KHO74_RS27430	COG3177	Filamentation induced by cAMP protein fic
KHO74_RS27505	COG2201	protein-glutamate methylesterase activity
KHO74_RS27575	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO74_RS27685	COG2205	protein histidine kinase activity
KHO74_RS27715	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KHO74_RS27745	COG3935	DnaD domain protein
KHO74_RS27760	COG2433	Pfam Transposase IS66
KHO74_RS27765	COG4372	Transposase