locus-tag	class	description
KHO73_RS00070	COG4771	TonB-dependent receptor
KHO73_RS00105	COG2755	lipolytic protein G-D-S-L family
KHO73_RS00105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KHO73_RS00140	COG4771	TonB-dependent receptor
KHO73_RS00155	COG1629	transport
KHO73_RS00170	COG2814	Major facilitator Superfamily
KHO73_RS00180	COG2081	HI0933 family
KHO73_RS00185	COG1940	carbohydrate kinase activity
KHO73_RS00200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KHO73_RS00210	COG0674	pyruvate-flavodoxin oxidoreductase activity
KHO73_RS00210	COG1013	pyruvate-flavodoxin oxidoreductase activity
KHO73_RS00210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KHO73_RS00210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KHO73_RS00215	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KHO73_RS00220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KHO73_RS00230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KHO73_RS00235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KHO73_RS00240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KHO73_RS00245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KHO73_RS00255	COG0242	peptide deformylase activity
KHO73_RS00260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KHO73_RS00280	COG2895	sulfate adenylyltransferase (ATP) activity
KHO73_RS00285	COG0175	sulfate reduction
KHO73_RS00290	COG0529	Catalyzes the synthesis of activated sulfate
KHO73_RS00295	COG0471	metal ion transport
KHO73_RS00295	COG3273	potassium ion transport
KHO73_RS00300	COG1218	3'(2'),5'-bisphosphate nucleotidase
KHO73_RS00310	COG4221	oxidoreductase activity
KHO73_RS00415	COG0740	serine-type endopeptidase activity
KHO73_RS00420	COG3415	Transposase
KHO73_RS00435	COG4383	Mu-like prophage protein gp29
KHO73_RS00600	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS00620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KHO73_RS00630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KHO73_RS00685	COG1216	Glycosyl transferase, family 2
KHO73_RS00690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KHO73_RS00700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KHO73_RS00710	COG1086	Polysaccharide biosynthesis protein
KHO73_RS00730	COG1086	Polysaccharide biosynthesis protein
KHO73_RS00770	COG1482	cell wall glycoprotein biosynthetic process
KHO73_RS00785	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KHO73_RS00790	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO73_RS00800	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO73_RS00805	COG3292	Two component regulator propeller
KHO73_RS00805	COG0745	RESPONSE REGULATOR receiver
KHO73_RS00805	COG2205	protein histidine kinase activity
KHO73_RS00815	COG1629	transport
KHO73_RS00815	COG4206	TonB-dependent receptor
KHO73_RS00820	COG0702	epimerase
KHO73_RS00825	COG1629	transport
KHO73_RS00825	COG4206	TonB-dependent receptor
KHO73_RS00830	COG0702	epimerase
KHO73_RS00865	COG2160	L-arabinose isomerase activity
KHO73_RS00870	COG1070	Carbohydrate kinase
KHO73_RS00885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KHO73_RS00890	COG0698	ribose 5-phosphate isomerase
KHO73_RS00910	COG5012	cobalamin binding
KHO73_RS00915	COG1501	Belongs to the glycosyl hydrolase 31 family
KHO73_RS00930	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KHO73_RS00975	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KHO73_RS01000	COG0673	inositol 2-dehydrogenase activity
KHO73_RS01005	COG0590	tRNA wobble adenosine to inosine editing
KHO73_RS01020	COG1629	transport
KHO73_RS01020	COG4206	TonB-dependent receptor
KHO73_RS01040	COG2433	Pfam Transposase IS66
KHO73_RS01060	COG2264	protein methyltransferase activity
KHO73_RS01070	COG0022	dehydrogenase e1 component
KHO73_RS01075	COG0508	dehydrogenase complex catalyzes the overall conversion of
KHO73_RS01100	COG1538	Outer membrane efflux protein
KHO73_RS01115	COG1752	Esterase of the alpha-beta hydrolase superfamily
KHO73_RS01150	COG1131	(ABC) transporter
KHO73_RS01195	COG0848	biopolymer transport protein
KHO73_RS01200	COG0811	peptide transport
KHO73_RS01265	COG4771	TonB-dependent receptor
KHO73_RS01280	COG0702	epimerase
KHO73_RS01290	COG1629	transport
KHO73_RS01295	COG2205	protein histidine kinase activity
KHO73_RS01295	COG3292	Two component regulator propeller
KHO73_RS01295	COG0745	RESPONSE REGULATOR receiver
KHO73_RS01330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KHO73_RS01335	COG0363	glucosamine-6-phosphate deaminase activity
KHO73_RS01355	COG1032	radical SAM domain protein
KHO73_RS01365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KHO73_RS01370	COG0463	Glycosyl transferase, family 2
KHO73_RS01380	COG0646	methionine synthase
KHO73_RS01380	COG1410	methionine synthase
KHO73_RS01395	COG1408	metallophosphoesterase
KHO73_RS01405	COG0420	3'-5' exonuclease activity
KHO73_RS01435	COG0641	radical SAM
KHO73_RS01440	COG3591	Belongs to the peptidase S1B family
KHO73_RS01445	COG3591	Belongs to the peptidase S1B family
KHO73_RS01475	COG1773	rubredoxin
KHO73_RS01475	COG1592	Rubrerythrin
KHO73_RS01495	COG1404	Belongs to the peptidase S8 family
KHO73_RS01525	COG4771	TonB-dependent receptor
KHO73_RS01530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KHO73_RS01530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KHO73_RS01540	COG0131	Imidazoleglycerol-phosphate dehydratase
KHO73_RS01545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KHO73_RS01550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KHO73_RS01555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KHO73_RS01575	COG2271	Major facilitator Superfamily
KHO73_RS01600	COG0702	epimerase
KHO73_RS01605	COG1629	transport
KHO73_RS01620	COG1741	Belongs to the pirin family
KHO73_RS01625	COG4232	protein-disulfide reductase activity
KHO73_RS01635	COG0572	uridine kinase
KHO73_RS01645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KHO73_RS01650	COG0778	Nitroreductase
KHO73_RS01655	COG1410	methionine synthase
KHO73_RS01655	COG0646	methionine synthase
KHO73_RS01660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KHO73_RS01725	COG0545	Peptidyl-prolyl cis-trans isomerase
KHO73_RS01730	COG2373	Large extracellular alpha-helical protein
KHO73_RS01735	COG4953	penicillin-binding protein 1C
KHO73_RS01740	COG2814	Major facilitator Superfamily
KHO73_RS01755	COG1757	Na H antiporter
KHO73_RS01765	COG2197	response regulator
KHO73_RS01770	COG0482	sulfurtransferase activity
KHO73_RS01775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KHO73_RS01800	COG0501	Belongs to the peptidase M48B family
KHO73_RS01805	COG1253	flavin adenine dinucleotide binding
KHO73_RS01815	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KHO73_RS01830	COG5492	domain, Protein
KHO73_RS01840	COG1629	transport
KHO73_RS01840	COG4206	TonB-dependent receptor
KHO73_RS01845	COG1595	DNA-templated transcription, initiation
KHO73_RS01850	COG2205	protein histidine kinase activity
KHO73_RS01850	COG0745	RESPONSE REGULATOR receiver
KHO73_RS01850	COG0745	RESPONSE REGULATOR receiver
KHO73_RS01850	COG3292	Two component regulator propeller
KHO73_RS01850	COG2205	protein histidine kinase activity
KHO73_RS01850	COG3292	Two component regulator propeller
KHO73_RS01875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KHO73_RS01880	COG1082	Xylose isomerase domain protein TIM barrel
KHO73_RS01885	COG1028	Short-chain dehydrogenase reductase Sdr
KHO73_RS01925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHO73_RS01940	COG1882	Formate acetyltransferase
KHO73_RS01945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KHO73_RS01950	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS01995	COG2271	Major facilitator Superfamily
KHO73_RS02000	COG0584	glycerophosphoryl diester phosphodiesterase
KHO73_RS02005	COG0584	glycerophosphoryl diester phosphodiesterase
KHO73_RS02015	COG4771	TonB-dependent receptor
KHO73_RS02025	COG1595	DNA-templated transcription, initiation
KHO73_RS02045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KHO73_RS02055	COG0583	DNA-binding transcription factor activity
KHO73_RS02060	COG0783	Belongs to the Dps family
KHO73_RS02100	COG4206	TonB-dependent receptor
KHO73_RS02100	COG1629	transport
KHO73_RS02115	COG0318	PFAM AMP-dependent synthetase and ligase
KHO73_RS02120	COG4948	Mandelate Racemase Muconate Lactonizing
KHO73_RS02125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KHO73_RS02130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KHO73_RS02135	COG1169	isochorismate synthase
KHO73_RS02140	COG0561	phosphatase activity
KHO73_RS02145	COG3189	MarR family transcriptional regulator
KHO73_RS02155	COG0456	acetyltransferase
KHO73_RS02160	COG1538	Outer membrane efflux protein
KHO73_RS02170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS02180	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KHO73_RS02190	COG1523	belongs to the glycosyl hydrolase 13 family
KHO73_RS02195	COG0668	transmembrane transport
KHO73_RS02210	COG1629	transport
KHO73_RS02220	COG3250	beta-galactosidase activity
KHO73_RS02235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS02250	COG4206	TonB-dependent receptor
KHO73_RS02250	COG1629	transport
KHO73_RS02270	COG1193	negative regulation of DNA recombination
KHO73_RS02275	COG0598	Magnesium transport protein CorA
KHO73_RS02280	COG1760	l-serine dehydratase
KHO73_RS02305	COG3292	Two component regulator propeller
KHO73_RS02305	COG0745	RESPONSE REGULATOR receiver
KHO73_RS02305	COG2205	protein histidine kinase activity
KHO73_RS02315	COG1629	transport
KHO73_RS02315	COG4206	TonB-dependent receptor
KHO73_RS02320	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KHO73_RS02335	COG3250	beta-galactosidase activity
KHO73_RS02345	COG0156	8-amino-7-oxononanoate synthase activity
KHO73_RS02385	COG4935	Belongs to the peptidase S8 family
KHO73_RS02385	COG1404	Belongs to the peptidase S8 family
KHO73_RS02405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KHO73_RS02410	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KHO73_RS02415	COG2205	protein histidine kinase activity
KHO73_RS02415	COG3292	Two component regulator propeller
KHO73_RS02415	COG0745	RESPONSE REGULATOR receiver
KHO73_RS02420	COG5434	Belongs to the glycosyl hydrolase 28 family
KHO73_RS02430	COG4771	TonB-dependent receptor
KHO73_RS02435	COG0702	epimerase
KHO73_RS02440	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KHO73_RS02450	COG3119	arylsulfatase activity
KHO73_RS02475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KHO73_RS02480	COG0038	chloride channel
KHO73_RS02530	COG0586	Pfam SNARE associated Golgi protein
KHO73_RS02540	COG0306	phosphate transporter
KHO73_RS02565	COG0326	Molecular chaperone. Has ATPase activity
KHO73_RS02630	COG0443	Heat shock 70 kDa protein
KHO73_RS02650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KHO73_RS02655	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KHO73_RS02660	COG2855	membrane
KHO73_RS02670	COG0583	DNA-binding transcription factor activity
KHO73_RS02680	COG0542	response to heat
KHO73_RS02695	COG0237	dephospho-CoA kinase activity
KHO73_RS02705	COG1862	Preprotein translocase
KHO73_RS02710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KHO73_RS02720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KHO73_RS02725	COG0193	aminoacyl-tRNA hydrolase activity
KHO73_RS02730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KHO73_RS02740	COG4651	solute:proton antiporter activity
KHO73_RS02740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KHO73_RS02745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KHO73_RS02750	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHO73_RS02755	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KHO73_RS02760	COG1082	Xylose isomerase domain protein TIM barrel
KHO73_RS02775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KHO73_RS02785	COG0148	phosphopyruvate hydratase activity
KHO73_RS02790	COG1595	DNA-templated transcription, initiation
KHO73_RS02815	COG3279	Response regulator of the LytR AlgR family
KHO73_RS02830	COG0463	Glycosyl transferase, family 2
KHO73_RS02845	COG1971	Probably functions as a manganese efflux pump
KHO73_RS02850	COG1477	protein flavinylation
KHO73_RS02860	COG0037	tRNA processing
KHO73_RS02875	COG4864	UPF0365 protein
KHO73_RS02885	COG2910	NAD(P)H-binding
KHO73_RS02895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KHO73_RS03005	COG3328	transposase activity
KHO73_RS03065	COG0653	protein targeting
KHO73_RS03075	COG0346	lactoylglutathione lyase activity
KHO73_RS03110	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KHO73_RS03115	COG3408	Glycogen debranching enzyme
KHO73_RS03130	COG0657	acetylesterase activity
KHO73_RS03135	COG0702	epimerase
KHO73_RS03140	COG1629	transport
KHO73_RS03145	COG2207	Transcriptional regulator
KHO73_RS03145	COG0662	Cupin 2, conserved barrel domain protein
KHO73_RS03150	COG0564	pseudouridine synthase activity
KHO73_RS03160	COG0534	Mate efflux family protein
KHO73_RS03175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KHO73_RS03205	COG0741	lytic transglycosylase activity
KHO73_RS03205	COG1388	LysM domain
KHO73_RS03210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KHO73_RS03220	COG1285	pathogenesis
KHO73_RS03260	COG1115	amino acid carrier protein
KHO73_RS03270	COG1509	lysine 2,3-aminomutase activity
KHO73_RS03275	COG2233	PERMEase
KHO73_RS03290	COG4206	TonB-dependent receptor
KHO73_RS03290	COG1629	transport
KHO73_RS03300	COG1393	Belongs to the ArsC family
KHO73_RS03310	COG2304	oxidoreductase activity
KHO73_RS03330	COG0351	phosphomethylpyrimidine kinase
KHO73_RS03340	COG1139	Iron-sulfur cluster binding protein
KHO73_RS03345	COG0247	lactate metabolic process
KHO73_RS03350	COG0602	queuosine metabolic process
KHO73_RS03360	COG2832	Protein of unknown function (DUF454)
KHO73_RS03365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KHO73_RS03375	COG0673	inositol 2-dehydrogenase activity
KHO73_RS03415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KHO73_RS03415	COG1333	cytochrome c biogenesis protein
KHO73_RS03440	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KHO73_RS03445	COG1063	alcohol dehydrogenase
KHO73_RS03450	COG1070	Carbohydrate kinase
KHO73_RS03480	COG1418	mRNA catabolic process
KHO73_RS03485	COG3142	Participates in the control of copper homeostasis
KHO73_RS03550	COG1629	transport
KHO73_RS03550	COG4206	TonB-dependent receptor
KHO73_RS03575	COG2706	6-phosphogluconolactonase activity
KHO73_RS03580	COG0457	Tetratricopeptide repeat
KHO73_RS03585	COG2814	Major facilitator Superfamily
KHO73_RS03595	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS03600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS03615	COG1496	oxidoreductase activity
KHO73_RS03620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KHO73_RS03625	COG0563	adenylate kinase activity
KHO73_RS03630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KHO73_RS03650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KHO73_RS03650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KHO73_RS03690	COG2204	response regulator
KHO73_RS03695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KHO73_RS03705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KHO73_RS03715	COG1253	flavin adenine dinucleotide binding
KHO73_RS03735	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KHO73_RS03745	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
KHO73_RS03750	COG0653	protein targeting
KHO73_RS03775	COG4206	TonB-dependent receptor
KHO73_RS03775	COG1629	transport
KHO73_RS03790	COG5002	protein histidine kinase activity
KHO73_RS03790	COG2205	protein histidine kinase activity
KHO73_RS03790	COG0784	Response regulator, receiver
KHO73_RS03795	COG0525	valine-tRNA ligase activity
KHO73_RS03810	COG3956	TIGRFAM MazG family protein
KHO73_RS03830	COG1234	tRNA 3'-trailer cleavage
KHO73_RS03840	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KHO73_RS03840	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KHO73_RS03870	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS03875	COG0492	ferredoxin-NADP+ reductase activity
KHO73_RS03885	COG1674	ftsk spoiiie
KHO73_RS03900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KHO73_RS03905	COG2211	Major facilitator Superfamily
KHO73_RS03925	COG1136	(ABC) transporter
KHO73_RS03940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KHO73_RS03945	COG1597	lipid kinase activity
KHO73_RS03950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KHO73_RS03955	COG0612	Peptidase, M16
KHO73_RS03970	COG0791	NLP P60 protein
KHO73_RS03985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KHO73_RS03990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KHO73_RS03995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KHO73_RS04005	COG0543	2 iron, 2 sulfur cluster binding
KHO73_RS04010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KHO73_RS04015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KHO73_RS04020	COG0297	glycogen (starch) synthase activity
KHO73_RS04035	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS04065	COG4771	TonB-dependent receptor
KHO73_RS04135	COG1216	Glycosyl transferase, family 2
KHO73_RS04140	COG2433	Pfam Transposase IS66
KHO73_RS04160	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS04240	COG0484	heat shock protein binding
KHO73_RS04280	COG0358	DNA primase activity
KHO73_RS04360	COG1192	Involved in chromosome partitioning
KHO73_RS04400	COG1373	ATPase (AAA superfamily
KHO73_RS04420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KHO73_RS04420	COG0551	DNA topoisomerase type I activity
KHO73_RS04510	COG2204	response regulator
KHO73_RS04540	COG4974	Belongs to the 'phage' integrase family
KHO73_RS04580	COG4771	TonB-dependent receptor
KHO73_RS04595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KHO73_RS04595	COG0519	Catalyzes the synthesis of GMP from XMP
KHO73_RS04600	COG1970	mechanosensitive ion channel activity
KHO73_RS04610	COG0339	signal peptide processing
KHO73_RS04620	COG2131	deaminase
KHO73_RS04625	COG0793	Belongs to the peptidase S41A family
KHO73_RS04630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KHO73_RS04635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KHO73_RS04645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHO73_RS04655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KHO73_RS04670	COG0673	inositol 2-dehydrogenase activity
KHO73_RS04675	COG5434	Belongs to the glycosyl hydrolase 28 family
KHO73_RS04695	COG4771	TonB-dependent receptor
KHO73_RS04715	COG0673	inositol 2-dehydrogenase activity
KHO73_RS04720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KHO73_RS04725	COG3250	beta-galactosidase activity
KHO73_RS04745	COG0101	tRNA pseudouridine synthase activity
KHO73_RS04750	COG3292	Two component regulator propeller
KHO73_RS04750	COG0745	RESPONSE REGULATOR receiver
KHO73_RS04750	COG2205	protein histidine kinase activity
KHO73_RS04785	COG5433	transposase activity
KHO73_RS04845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHO73_RS04865	COG2268	Band 7 protein
KHO73_RS04875	COG1702	phosphate starvation-inducible protein PhoH
KHO73_RS04880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KHO73_RS04885	COG2226	methyltransferase
KHO73_RS04890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KHO73_RS04905	COG1704	LemA family
KHO73_RS04915	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KHO73_RS04920	COG0284	orotidine-5'-phosphate decarboxylase activity
KHO73_RS04925	COG1078	dGTPase activity
KHO73_RS04930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KHO73_RS04935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KHO73_RS04935	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KHO73_RS04950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KHO73_RS04995	COG0823	Involved in the tonB-independent uptake of proteins
KHO73_RS04995	COG1506	peptidase
KHO73_RS05000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KHO73_RS05010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KHO73_RS05020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KHO73_RS05040	COG0546	phosphoglycolate phosphatase activity
KHO73_RS05050	COG0745	RESPONSE REGULATOR receiver
KHO73_RS05050	COG2205	protein histidine kinase activity
KHO73_RS05050	COG3292	Two component regulator propeller
KHO73_RS05055	COG3250	beta-galactosidase activity
KHO73_RS05070	COG2205	protein histidine kinase activity
KHO73_RS05070	COG0745	RESPONSE REGULATOR receiver
KHO73_RS05070	COG0745	RESPONSE REGULATOR receiver
KHO73_RS05070	COG2205	protein histidine kinase activity
KHO73_RS05070	COG3292	Two component regulator propeller
KHO73_RS05070	COG3292	Two component regulator propeller
KHO73_RS05075	COG3254	rhamnose metabolic process
KHO73_RS05085	COG3401	FG-GAP repeat protein
KHO73_RS05095	COG2755	lipolytic protein G-D-S-L family
KHO73_RS05120	COG4771	TonB-dependent receptor
KHO73_RS05135	COG0702	epimerase
KHO73_RS05140	COG4771	TonB-dependent receptor
KHO73_RS05165	COG3328	transposase activity
KHO73_RS05175	COG4771	TonB-dependent receptor
KHO73_RS05180	COG0702	epimerase
KHO73_RS05195	COG4771	TonB-dependent receptor
KHO73_RS05235	COG3345	alpha-galactosidase
KHO73_RS05245	COG3250	beta-galactosidase activity
KHO73_RS05250	COG3401	FG-GAP repeat protein
KHO73_RS05285	COG2755	lipolytic protein G-D-S-L family
KHO73_RS05310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KHO73_RS05355	COG1595	DNA-templated transcription, initiation
KHO73_RS05360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KHO73_RS05360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KHO73_RS05365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KHO73_RS05370	COG0569	domain protein
KHO73_RS05370	COG2985	domain, Protein
KHO73_RS05410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KHO73_RS05415	COG1120	ATPase activity
KHO73_RS05430	COG2188	Transcriptional regulator
KHO73_RS05450	COG1629	transport
KHO73_RS05450	COG4206	TonB-dependent receptor
KHO73_RS05625	COG4383	Mu-like prophage protein gp29
KHO73_RS05640	COG3415	Transposase
KHO73_RS05645	COG0740	serine-type endopeptidase activity
KHO73_RS05720	COG4771	TonB-dependent receptor
KHO73_RS05780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS05785	COG1609	Transcriptional regulator
KHO73_RS05785	COG2207	Transcriptional regulator
KHO73_RS05795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KHO73_RS05800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KHO73_RS05805	COG0166	Belongs to the GPI family
KHO73_RS05905	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS05950	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KHO73_RS05955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KHO73_RS05960	COG1086	Polysaccharide biosynthesis protein
KHO73_RS06055	COG2502	aspartate--ammonia ligase
KHO73_RS06060	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KHO73_RS06085	COG3876	Protein conserved in bacteria
KHO73_RS06105	COG0860	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS06115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KHO73_RS06120	COG0778	Nitroreductase
KHO73_RS06125	COG4974	Belongs to the 'phage' integrase family
KHO73_RS06200	COG1640	4-alpha-glucanotransferase
KHO73_RS06215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KHO73_RS06235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KHO73_RS06240	COG0318	PFAM AMP-dependent synthetase and ligase
KHO73_RS06275	COG0359	binds to the 23S rRNA
KHO73_RS06280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KHO73_RS06285	COG0360	Binds together with S18 to 16S ribosomal RNA
KHO73_RS06310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KHO73_RS06315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KHO73_RS06370	COG1131	(ABC) transporter
KHO73_RS06380	COG2431	L-lysine efflux transmembrane transporter activity
KHO73_RS06390	COG1193	negative regulation of DNA recombination
KHO73_RS06415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KHO73_RS06430	COG2234	aminopeptidase activity
KHO73_RS06435	COG3250	beta-galactosidase activity
KHO73_RS06455	COG0702	epimerase
KHO73_RS06460	COG1629	transport
KHO73_RS06475	COG3537	Alpha-1,2-mannosidase
KHO73_RS06490	COG1629	transport
KHO73_RS06490	COG4206	TonB-dependent receptor
KHO73_RS06510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KHO73_RS06515	COG0802	atpase or kinase
KHO73_RS06530	COG0714	Associated with various cellular activities
KHO73_RS06580	COG3118	belongs to the thioredoxin family
KHO73_RS06590	COG0688	phosphatidylethanolamine metabolic process
KHO73_RS06595	COG1183	phosphatidylcholine synthase activity
KHO73_RS06615	COG0792	nuclease activity
KHO73_RS06640	COG0534	Mate efflux family protein
KHO73_RS06645	COG0528	UMP kinase activity
KHO73_RS06680	COG0233	cytoplasmic translational termination
KHO73_RS06685	COG1162	GTPase activity
KHO73_RS06695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KHO73_RS06715	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KHO73_RS06715	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KHO73_RS06725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KHO73_RS06735	COG1629	transport
KHO73_RS06735	COG4206	TonB-dependent receptor
KHO73_RS06740	COG4974	Belongs to the 'phage' integrase family
KHO73_RS06745	COG1629	transport
KHO73_RS06765	COG4771	TonB-dependent receptor
KHO73_RS06775	COG2095	MarC family integral membrane protein
KHO73_RS06790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KHO73_RS06800	COG1435	thymidine kinase activity
KHO73_RS06805	COG0628	permease
KHO73_RS06845	COG2433	Pfam Transposase IS66
KHO73_RS06885	COG1396	sequence-specific DNA binding
KHO73_RS06895	COG4771	TonB-dependent receptor
KHO73_RS06905	COG4771	TonB-dependent receptor
KHO73_RS06940	COG0693	protein deglycase activity
KHO73_RS07010	COG0300	oxidoreductase activity
KHO73_RS07015	COG3328	transposase activity
KHO73_RS07020	COG0456	acetyltransferase
KHO73_RS07025	COG0110	maltose O-acetyltransferase activity
KHO73_RS07035	COG1522	sequence-specific DNA binding
KHO73_RS07060	COG0745	RESPONSE REGULATOR receiver
KHO73_RS07060	COG2205	protein histidine kinase activity
KHO73_RS07060	COG3292	Two component regulator propeller
KHO73_RS07070	COG1629	transport
KHO73_RS07095	COG2818	Glycosylase
KHO73_RS07105	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
KHO73_RS07110	COG0460	homoserine dehydrogenase
KHO73_RS07110	COG0527	aspartate kinase activity
KHO73_RS07115	COG0252	asparaginase activity
KHO73_RS07125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KHO73_RS07130	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KHO73_RS07140	COG4771	TonB-dependent receptor
KHO73_RS07160	COG0826	peptidase U32
KHO73_RS07165	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KHO73_RS07175	COG0436	Aminotransferase
KHO73_RS07180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KHO73_RS07200	COG0519	Catalyzes the synthesis of GMP from XMP
KHO73_RS07205	COG5002	protein histidine kinase activity
KHO73_RS07210	COG2205	protein histidine kinase activity
KHO73_RS07220	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KHO73_RS07230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KHO73_RS07265	COG2193	ferroxidase activity
KHO73_RS07275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KHO73_RS07280	COG0470	DNA polymerase III
KHO73_RS07285	COG1774	PSP1 C-terminal conserved region
KHO73_RS07295	COG0772	Belongs to the SEDS family
KHO73_RS07320	COG0138	bifunctional purine biosynthesis protein purh
KHO73_RS07325	COG3590	peptidase
KHO73_RS07330	COG0488	(ABC) transporter
KHO73_RS07355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHO73_RS07355	COG2205	protein histidine kinase activity
KHO73_RS07360	COG0534	Mate efflux family protein
KHO73_RS07365	COG0612	Peptidase, M16
KHO73_RS07370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KHO73_RS07375	COG2204	response regulator
KHO73_RS07380	COG0745	RESPONSE REGULATOR receiver
KHO73_RS07380	COG2205	protein histidine kinase activity
KHO73_RS07380	COG3292	Two component regulator propeller
KHO73_RS07385	COG3119	arylsulfatase activity
KHO73_RS07400	COG3119	arylsulfatase activity
KHO73_RS07430	COG4771	TonB-dependent receptor
KHO73_RS07440	COG0745	RESPONSE REGULATOR receiver
KHO73_RS07440	COG3292	Two component regulator propeller
KHO73_RS07440	COG2205	protein histidine kinase activity
KHO73_RS07445	COG3537	Alpha-1,2-mannosidase
KHO73_RS07505	COG0564	pseudouridine synthase activity
KHO73_RS07535	COG1454	alcohol dehydrogenase
KHO73_RS07540	COG0235	Class ii aldolase
KHO73_RS07550	COG4806	L-rhamnose isomerase
KHO73_RS07555	COG1070	Carbohydrate kinase
KHO73_RS07560	COG1438	arginine binding
KHO73_RS07570	COG0137	argininosuccinate synthase activity
KHO73_RS07575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KHO73_RS07580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KHO73_RS07585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KHO73_RS07590	COG1396	sequence-specific DNA binding
KHO73_RS07590	COG1917	Cupin 2, conserved barrel domain protein
KHO73_RS07595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KHO73_RS07615	COG4771	TonB-dependent receptor
KHO73_RS07670	COG0471	metal ion transport
KHO73_RS07705	COG3328	transposase activity
KHO73_RS07710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KHO73_RS07725	COG0165	Argininosuccinate lyase
KHO73_RS07735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KHO73_RS07745	COG2890	protein-(glutamine-N5) methyltransferase activity
KHO73_RS07750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KHO73_RS07750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KHO73_RS07760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KHO73_RS07765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KHO73_RS07785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KHO73_RS07795	COG0436	Aminotransferase
KHO73_RS07800	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KHO73_RS07805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KHO73_RS07810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KHO73_RS07830	COG1181	Belongs to the D-alanine--D-alanine ligase family
KHO73_RS07835	COG0564	pseudouridine synthase activity
KHO73_RS07840	COG0515	serine threonine protein kinase
KHO73_RS07840	COG2815	serine threonine protein kinase
KHO73_RS07845	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KHO73_RS07850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KHO73_RS07855	COG1785	Belongs to the alkaline phosphatase family
KHO73_RS07865	COG0366	Alpha amylase catalytic
KHO73_RS07870	COG1082	Xylose isomerase domain protein TIM barrel
KHO73_RS07875	COG1629	transport
KHO73_RS07875	COG4206	TonB-dependent receptor
KHO73_RS07880	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KHO73_RS07895	COG0366	Alpha amylase catalytic
KHO73_RS07900	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KHO73_RS07910	COG2003	Belongs to the UPF0758 family
KHO73_RS07915	COG0463	Glycosyl transferase, family 2
KHO73_RS07915	COG1216	Glycosyl transferase, family 2
KHO73_RS07920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KHO73_RS07925	COG0280	phosphate acetyltransferase
KHO73_RS07930	COG1380	Effector of murein hydrolase LrgA
KHO73_RS07935	COG1346	cytolysis
KHO73_RS07980	COG1629	transport
KHO73_RS07995	COG2205	protein histidine kinase activity
KHO73_RS07995	COG0745	RESPONSE REGULATOR receiver
KHO73_RS07995	COG3292	Two component regulator propeller
KHO73_RS08000	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHO73_RS08030	COG1082	Xylose isomerase domain protein TIM barrel
KHO73_RS08035	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO73_RS08060	COG4948	Mandelate Racemase Muconate Lactonizing
KHO73_RS08070	COG1501	Belongs to the glycosyl hydrolase 31 family
KHO73_RS08080	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO73_RS08110	COG1704	LemA family
KHO73_RS08115	COG0312	modulator of DNA gyrase
KHO73_RS08120	COG0312	modulator of DNA gyrase
KHO73_RS08125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KHO73_RS08130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KHO73_RS08135	COG0784	Response regulator, receiver
KHO73_RS08135	COG5002	protein histidine kinase activity
KHO73_RS08140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KHO73_RS08150	COG0733	neurotransmitter:sodium symporter activity
KHO73_RS08160	COG1136	(ABC) transporter
KHO73_RS08165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KHO73_RS08170	COG0589	response to stress
KHO73_RS08170	COG0475	glutathione-regulated potassium exporter activity
KHO73_RS08180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KHO73_RS08190	COG1216	Glycosyl transferase, family 2
KHO73_RS08190	COG0463	Glycosyl transferase, family 2
KHO73_RS08195	COG0562	UDP-galactopyranose mutase
KHO73_RS08250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS08325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KHO73_RS08330	COG1215	transferase activity, transferring glycosyl groups
KHO73_RS08335	COG2385	sporulation resulting in formation of a cellular spore
KHO73_RS08335	COG2247	cell wall binding repeat
KHO73_RS08340	COG2211	Major facilitator Superfamily
KHO73_RS08355	COG1063	alcohol dehydrogenase
KHO73_RS08360	COG0738	Major facilitator superfamily
KHO73_RS08375	COG1609	Transcriptional regulator
KHO73_RS08385	COG0423	glycine-tRNA ligase activity
KHO73_RS08395	COG2207	Transcriptional regulator
KHO73_RS08395	COG1609	Transcriptional regulator
KHO73_RS08400	COG3458	cephalosporin-C deacetylase activity
KHO73_RS08410	COG2814	Major facilitator Superfamily
KHO73_RS08420	COG4771	TonB-dependent receptor
KHO73_RS08435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KHO73_RS08435	COG0517	IMP dehydrogenase activity
KHO73_RS08450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS08480	COG3345	alpha-galactosidase
KHO73_RS08500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KHO73_RS08505	COG0363	glucosamine-6-phosphate deaminase activity
KHO73_RS08525	COG0673	inositol 2-dehydrogenase activity
KHO73_RS08530	COG0673	inositol 2-dehydrogenase activity
KHO73_RS08585	COG4771	TonB-dependent receptor
KHO73_RS08595	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO73_RS08660	COG2954	triphosphatase activity
KHO73_RS08880	COG0517	IMP dehydrogenase activity
KHO73_RS08895	COG0517	IMP dehydrogenase activity
KHO73_RS08900	COG0517	IMP dehydrogenase activity
KHO73_RS08905	COG4974	Belongs to the 'phage' integrase family
KHO73_RS08920	COG0551	DNA topoisomerase type I activity
KHO73_RS08920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KHO73_RS08935	COG4804	nuclease activity
KHO73_RS08970	COG0612	Peptidase, M16
KHO73_RS08975	COG1022	Amp-dependent synthetase and ligase
KHO73_RS08980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KHO73_RS08985	COG1373	ATPase (AAA superfamily
KHO73_RS09045	COG2017	converts alpha-aldose to the beta-anomer
KHO73_RS09055	COG3537	Alpha-1,2-mannosidase
KHO73_RS09070	COG3537	Alpha-1,2-mannosidase
KHO73_RS09105	COG0561	phosphatase activity
KHO73_RS09110	COG1629	transport
KHO73_RS09140	COG3250	beta-galactosidase activity
KHO73_RS09175	COG0702	epimerase
KHO73_RS09180	COG4771	TonB-dependent receptor
KHO73_RS09215	COG3119	arylsulfatase activity
KHO73_RS09230	COG1629	transport
KHO73_RS09265	COG4771	TonB-dependent receptor
KHO73_RS09270	COG0702	epimerase
KHO73_RS09310	COG4771	TonB-dependent receptor
KHO73_RS09330	COG0745	RESPONSE REGULATOR receiver
KHO73_RS09330	COG2205	protein histidine kinase activity
KHO73_RS09330	COG3292	Two component regulator propeller
KHO73_RS09335	COG4942	peptidase
KHO73_RS09350	COG0756	dUTP diphosphatase activity
KHO73_RS09355	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KHO73_RS09370	COG1595	DNA-templated transcription, initiation
KHO73_RS09375	COG2001	Belongs to the MraZ family
KHO73_RS09380	COG0275	rRNA processing
KHO73_RS09395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KHO73_RS09400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KHO73_RS09405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KHO73_RS09410	COG0772	Belongs to the SEDS family
KHO73_RS09415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KHO73_RS09425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KHO73_RS09440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KHO73_RS09445	COG1610	YqeY-like protein
KHO73_RS09470	COG2433	Pfam Transposase IS66
KHO73_RS09515	COG1381	Involved in DNA repair and RecF pathway recombination
KHO73_RS09565	COG0268	Binds directly to 16S ribosomal RNA
KHO73_RS09570	COG0187	DNA topoisomerase II activity
KHO73_RS09585	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KHO73_RS09605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KHO73_RS09610	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KHO73_RS09620	COG0393	Putative heavy-metal-binding
KHO73_RS09625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KHO73_RS09630	COG0719	Fe-S assembly protein
KHO73_RS09635	COG0396	ATPase activity
KHO73_RS09640	COG0719	Fe-S assembly protein
KHO73_RS09650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KHO73_RS09655	COG0195	Participates in both transcription termination and antitermination
KHO73_RS09660	COG0779	Required for maturation of 30S ribosomal subunits
KHO73_RS09685	COG1595	DNA-templated transcription, initiation
KHO73_RS09690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KHO73_RS09695	COG1166	arginine decarboxylase activity
KHO73_RS09700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KHO73_RS09710	COG0328	RNA-DNA hybrid ribonuclease activity
KHO73_RS09710	COG3341	Caulimovirus viroplasmin
KHO73_RS09735	COG1132	(ABC) transporter
KHO73_RS09765	COG0463	Glycosyl transferase, family 2
KHO73_RS09785	COG0436	Aminotransferase
KHO73_RS09790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KHO73_RS09815	COG1215	transferase activity, transferring glycosyl groups
KHO73_RS09840	COG1216	Glycosyl transferase, family 2
KHO73_RS09840	COG1442	glycosyl transferase family 8
KHO73_RS09870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KHO73_RS09880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KHO73_RS09885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KHO73_RS09890	COG0571	ribonuclease III activity
KHO73_RS09895	COG0205	6-phosphofructokinase activity
KHO73_RS09905	COG0482	sulfurtransferase activity
KHO73_RS09910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KHO73_RS09915	COG0561	phosphatase activity
KHO73_RS09960	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS09985	COG0215	cysteine-tRNA ligase activity
KHO73_RS09990	COG5492	domain, Protein
KHO73_RS09995	COG3119	arylsulfatase activity
KHO73_RS10000	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KHO73_RS10010	COG4771	TonB-dependent receptor
KHO73_RS10015	COG0702	epimerase
KHO73_RS10040	COG3250	beta-galactosidase activity
KHO73_RS10045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS10055	COG1538	Outer membrane efflux protein
KHO73_RS10060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KHO73_RS10070	COG2205	protein histidine kinase activity
KHO73_RS10070	COG2205	protein histidine kinase activity
KHO73_RS10070	COG0745	RESPONSE REGULATOR receiver
KHO73_RS10070	COG3292	Two component regulator propeller
KHO73_RS10070	COG3292	Two component regulator propeller
KHO73_RS10070	COG0745	RESPONSE REGULATOR receiver
KHO73_RS10075	COG3119	arylsulfatase activity
KHO73_RS10080	COG4771	TonB-dependent receptor
KHO73_RS10085	COG0702	epimerase
KHO73_RS10105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KHO73_RS10125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KHO73_RS10175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KHO73_RS10185	COG0681	Belongs to the peptidase S26 family
KHO73_RS10200	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO73_RS10215	COG0702	epimerase
KHO73_RS10220	COG4771	TonB-dependent receptor
KHO73_RS10230	COG0612	Peptidase, M16
KHO73_RS10255	COG0513	Belongs to the DEAD box helicase family
KHO73_RS10260	COG2205	protein histidine kinase activity
KHO73_RS10260	COG3292	Two component regulator propeller
KHO73_RS10260	COG0745	RESPONSE REGULATOR receiver
KHO73_RS10280	COG4771	TonB-dependent receptor
KHO73_RS10285	COG0702	epimerase
KHO73_RS10305	COG4948	Mandelate Racemase Muconate Lactonizing
KHO73_RS10310	COG3250	beta-galactosidase activity
KHO73_RS10315	COG3250	beta-galactosidase activity
KHO73_RS10330	COG3591	Belongs to the peptidase S1B family
KHO73_RS10350	COG2255	four-way junction helicase activity
KHO73_RS10355	COG0700	Nucleoside recognition
KHO73_RS10360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KHO73_RS10380	COG4206	TonB-dependent receptor
KHO73_RS10380	COG1629	transport
KHO73_RS10390	COG2197	response regulator
KHO73_RS10420	COG4771	TonB-dependent receptor
KHO73_RS10435	COG0445	tRNA wobble uridine modification
KHO73_RS10440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KHO73_RS10445	COG0322	excinuclease ABC activity
KHO73_RS10450	COG1490	D-aminoacyl-tRNA deacylase activity
KHO73_RS10455	COG1694	Mazg nucleotide pyrophosphohydrolase
KHO73_RS10470	COG0142	geranyltranstransferase activity
KHO73_RS10475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KHO73_RS10475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KHO73_RS10485	COG3279	Response regulator of the LytR AlgR family
KHO73_RS10490	COG3275	phosphorelay sensor kinase activity
KHO73_RS10495	COG1045	serine acetyltransferase
KHO73_RS10500	COG0116	Belongs to the methyltransferase superfamily
KHO73_RS10500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KHO73_RS10505	COG0823	Involved in the tonB-independent uptake of proteins
KHO73_RS10505	COG1506	peptidase
KHO73_RS10520	COG1238	metal cluster binding
KHO73_RS10525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KHO73_RS10525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KHO73_RS10535	COG1121	(ABC) transporter
KHO73_RS10550	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KHO73_RS10580	COG1629	transport
KHO73_RS10580	COG4206	TonB-dependent receptor
KHO73_RS10615	COG1028	Short-chain dehydrogenase reductase Sdr
KHO73_RS10620	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KHO73_RS10630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KHO73_RS10640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KHO73_RS10645	COG0594	ribonuclease P activity
KHO73_RS10695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KHO73_RS10710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KHO73_RS10720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KHO73_RS10725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KHO73_RS10730	COG1968	undecaprenyl-diphosphatase activity
KHO73_RS10740	COG2177	Part of the ABC transporter FtsEX involved in
KHO73_RS10790	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS10815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KHO73_RS10825	COG0427	acetyl-CoA hydrolase
KHO73_RS10930	COG0358	DNA primase activity
KHO73_RS11035	COG0519	Catalyzes the synthesis of GMP from XMP
KHO73_RS11060	COG2205	protein histidine kinase activity
KHO73_RS11060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHO73_RS11060	COG2198	Histidine kinase
KHO73_RS11060	COG0784	Response regulator, receiver
KHO73_RS11080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KHO73_RS11080	COG0551	DNA topoisomerase type I activity
KHO73_RS11120	COG1204	response to ionizing radiation
KHO73_RS11130	COG4974	Belongs to the 'phage' integrase family
KHO73_RS11145	COG1592	Rubrerythrin
KHO73_RS11150	COG0659	secondary active sulfate transmembrane transporter activity
KHO73_RS11160	COG3250	beta-galactosidase activity
KHO73_RS11165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS11170	COG3119	arylsulfatase activity
KHO73_RS11195	COG0745	RESPONSE REGULATOR receiver
KHO73_RS11195	COG2205	protein histidine kinase activity
KHO73_RS11195	COG3292	Two component regulator propeller
KHO73_RS11195	COG2205	protein histidine kinase activity
KHO73_RS11195	COG0745	RESPONSE REGULATOR receiver
KHO73_RS11195	COG3292	Two component regulator propeller
KHO73_RS11220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KHO73_RS11220	COG0731	radical SAM domain protein
KHO73_RS11240	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KHO73_RS11245	COG4948	Mandelate Racemase Muconate Lactonizing
KHO73_RS11250	COG0584	glycerophosphoryl diester phosphodiesterase
KHO73_RS11260	COG5434	Belongs to the glycosyl hydrolase 28 family
KHO73_RS11280	COG1629	transport
KHO73_RS11290	COG0745	RESPONSE REGULATOR receiver
KHO73_RS11290	COG2205	protein histidine kinase activity
KHO73_RS11290	COG2205	protein histidine kinase activity
KHO73_RS11290	COG3292	Two component regulator propeller
KHO73_RS11290	COG3292	Two component regulator propeller
KHO73_RS11290	COG0745	RESPONSE REGULATOR receiver
KHO73_RS11310	COG3537	Alpha-1,2-mannosidase
KHO73_RS11315	COG1360	Flagellar Motor Protein
KHO73_RS11320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KHO73_RS11325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KHO73_RS11330	COG0495	leucyl-tRNA aminoacylation
KHO73_RS11340	COG0697	spore germination
KHO73_RS11345	COG0662	Cupin 2, conserved barrel domain protein
KHO73_RS11345	COG2207	Transcriptional regulator
KHO73_RS11350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHO73_RS11365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KHO73_RS11370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KHO73_RS11375	COG0012	GTP binding
KHO73_RS11380	COG1012	belongs to the aldehyde dehydrogenase family
KHO73_RS11390	COG2814	Major facilitator Superfamily
KHO73_RS11395	COG1073	alpha beta
KHO73_RS11410	COG3119	arylsulfatase activity
KHO73_RS11435	COG4771	TonB-dependent receptor
KHO73_RS11445	COG3119	arylsulfatase activity
KHO73_RS11465	COG3292	Two component regulator propeller
KHO73_RS11465	COG2205	protein histidine kinase activity
KHO73_RS11465	COG0745	RESPONSE REGULATOR receiver
KHO73_RS11475	COG3408	Glycogen debranching enzyme
KHO73_RS11475	COG3119	arylsulfatase activity
KHO73_RS11500	COG4771	TonB-dependent receptor
KHO73_RS11505	COG0702	epimerase
KHO73_RS11525	COG1501	Belongs to the glycosyl hydrolase 31 family
KHO73_RS11540	COG1621	beta-fructofuranosidase activity
KHO73_RS11545	COG1917	Cupin 2, conserved barrel domain protein
KHO73_RS11555	COG4948	Mandelate Racemase Muconate Lactonizing
KHO73_RS11565	COG0561	phosphatase activity
KHO73_RS11570	COG4206	TonB-dependent receptor
KHO73_RS11570	COG1629	transport
KHO73_RS11590	COG0557	exoribonuclease II activity
KHO73_RS11605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KHO73_RS11610	COG0826	peptidase U32
KHO73_RS11620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KHO73_RS11620	COG0758	DNA mediated transformation
KHO73_RS11640	COG3345	alpha-galactosidase
KHO73_RS11675	COG3119	arylsulfatase activity
KHO73_RS11685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KHO73_RS11690	COG1053	succinate dehydrogenase
KHO73_RS11705	COG3119	arylsulfatase activity
KHO73_RS11715	COG0745	RESPONSE REGULATOR receiver
KHO73_RS11715	COG2205	protein histidine kinase activity
KHO73_RS11715	COG3292	Two component regulator propeller
KHO73_RS11730	COG1629	transport
KHO73_RS11780	COG0793	Belongs to the peptidase S41A family
KHO73_RS11780	COG3409	Peptidoglycan-binding domain 1 protein
KHO73_RS11785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KHO73_RS11805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KHO73_RS11810	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KHO73_RS11830	COG4771	TonB-dependent receptor
KHO73_RS11835	COG1373	ATPase (AAA superfamily
KHO73_RS11875	COG4206	TonB-dependent receptor
KHO73_RS11875	COG1629	transport
KHO73_RS11890	COG1501	Belongs to the glycosyl hydrolase 31 family
KHO73_RS11895	COG4206	TonB-dependent receptor
KHO73_RS11895	COG1629	transport
KHO73_RS11940	COG0561	phosphatase activity
KHO73_RS11945	COG1629	transport
KHO73_RS11960	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO73_RS12005	COG0545	Peptidyl-prolyl cis-trans isomerase
KHO73_RS12010	COG0545	Peptidyl-prolyl cis-trans isomerase
KHO73_RS12015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KHO73_RS12035	COG2205	protein histidine kinase activity
KHO73_RS12035	COG3292	Two component regulator propeller
KHO73_RS12035	COG2205	protein histidine kinase activity
KHO73_RS12035	COG0745	RESPONSE REGULATOR receiver
KHO73_RS12035	COG0745	RESPONSE REGULATOR receiver
KHO73_RS12035	COG3292	Two component regulator propeller
KHO73_RS12045	COG3250	beta-galactosidase activity
KHO73_RS12050	COG4771	TonB-dependent receptor
KHO73_RS12055	COG0702	epimerase
KHO73_RS12070	COG5492	domain, Protein
KHO73_RS12095	COG1216	Glycosyl transferase, family 2
KHO73_RS12100	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS12105	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KHO73_RS12140	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS12150	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS12170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHO73_RS12170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHO73_RS12225	COG3292	Two component regulator propeller
KHO73_RS12225	COG2205	protein histidine kinase activity
KHO73_RS12225	COG0745	RESPONSE REGULATOR receiver
KHO73_RS12230	COG0673	inositol 2-dehydrogenase activity
KHO73_RS12240	COG0673	inositol 2-dehydrogenase activity
KHO73_RS12320	COG0702	epimerase
KHO73_RS12340	COG3250	beta-galactosidase activity
KHO73_RS12345	COG3634	alkyl hydroperoxide reductase activity
KHO73_RS12370	COG3250	beta-galactosidase activity
KHO73_RS12390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KHO73_RS12395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KHO73_RS12415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KHO73_RS12440	COG2244	polysaccharide biosynthetic process
KHO73_RS12470	COG3754	Rhamnan synthesis protein F
KHO73_RS12505	COG1215	transferase activity, transferring glycosyl groups
KHO73_RS12515	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS12520	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS12525	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS12535	COG0489	protein tyrosine kinase activity
KHO73_RS12535	COG3206	protein involved in exopolysaccharide biosynthesis
KHO73_RS12555	COG2205	protein histidine kinase activity
KHO73_RS12575	COG0606	chelatase, subunit chli
KHO73_RS12590	COG4974	Belongs to the 'phage' integrase family
KHO73_RS12610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KHO73_RS12615	COG4591	ABC-type transport system involved in lipoprotein release permease component
KHO73_RS12620	COG1013	pyruvate-flavodoxin oxidoreductase activity
KHO73_RS12625	COG0674	pyruvate-flavodoxin oxidoreductase activity
KHO73_RS12625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KHO73_RS12685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHO73_RS12690	COG3723	Recombinational DNA repair protein, rece pathway
KHO73_RS12755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KHO73_RS13015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KHO73_RS13020	COG0339	signal peptide processing
KHO73_RS13035	COG0705	Rhomboid family
KHO73_RS13045	COG0018	arginyl-trna synthetase
KHO73_RS13060	COG3292	Two component regulator propeller
KHO73_RS13060	COG3292	Two component regulator propeller
KHO73_RS13060	COG2205	protein histidine kinase activity
KHO73_RS13060	COG0745	RESPONSE REGULATOR receiver
KHO73_RS13060	COG2205	protein histidine kinase activity
KHO73_RS13060	COG0745	RESPONSE REGULATOR receiver
KHO73_RS13100	COG1629	transport
KHO73_RS13115	COG2816	NAD+ diphosphatase activity
KHO73_RS13120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KHO73_RS13125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KHO73_RS13135	COG3634	alkyl hydroperoxide reductase activity
KHO73_RS13165	COG4771	TonB-dependent receptor
KHO73_RS13170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KHO73_RS13175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KHO73_RS13185	COG0483	inositol monophosphate 1-phosphatase activity
KHO73_RS13205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KHO73_RS13210	COG0793	Belongs to the peptidase S41A family
KHO73_RS13215	COG2205	protein histidine kinase activity
KHO73_RS13215	COG4999	Histidine kinase
KHO73_RS13215	COG3850	Histidine kinase
KHO73_RS13215	COG3437	response regulator, receiver
KHO73_RS13220	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KHO73_RS13250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KHO73_RS13255	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KHO73_RS13260	COG2059	Chromate
KHO73_RS13275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KHO73_RS13290	COG1396	sequence-specific DNA binding
KHO73_RS13295	COG0318	PFAM AMP-dependent synthetase and ligase
KHO73_RS13300	COG0662	Cupin 2, conserved barrel domain protein
KHO73_RS13300	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KHO73_RS13415	COG2096	Adenosyltransferase
KHO73_RS13450	COG0582	viral genome integration into host DNA
KHO73_RS13455	COG0535	radical SAM domain protein
KHO73_RS13485	COG0252	asparaginase activity
KHO73_RS13490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KHO73_RS13495	COG1027	Aspartate ammonia-lyase
KHO73_RS13525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KHO73_RS13535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KHO73_RS13545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KHO73_RS13560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KHO73_RS13565	COG0006	proline dipeptidase activity
KHO73_RS13570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KHO73_RS13575	COG4974	Belongs to the 'phage' integrase family
KHO73_RS13605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KHO73_RS13615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KHO73_RS13625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KHO73_RS13630	COG0081	regulation of translation
KHO73_RS13635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KHO73_RS13640	COG0222	ribosome binding
KHO73_RS13645	COG0085	RNA polymerase activity
KHO73_RS13650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KHO73_RS13660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KHO73_RS13665	COG0049	tRNA binding
KHO73_RS13670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KHO73_RS13675	COG0051	transcription antitermination factor activity, RNA binding
KHO73_RS13680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KHO73_RS13685	COG0088	Forms part of the polypeptide exit tunnel
KHO73_RS13690	COG0089	rRNA binding
KHO73_RS13695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KHO73_RS13700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KHO73_RS13705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KHO73_RS13710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KHO73_RS13715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KHO73_RS13720	COG0255	Belongs to the universal ribosomal protein uL29 family
KHO73_RS13725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KHO73_RS13730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KHO73_RS13735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KHO73_RS13740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KHO73_RS13745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KHO73_RS13750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KHO73_RS13755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KHO73_RS13760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KHO73_RS13765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KHO73_RS13770	COG1841	ribosomal large subunit assembly
KHO73_RS13775	COG0200	Binds to the 23S rRNA
KHO73_RS13790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KHO73_RS13795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KHO73_RS13800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KHO73_RS13805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KHO73_RS13810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KHO73_RS13815	COG0202	RNA polymerase activity
KHO73_RS13820	COG0203	ribosomal protein L17
KHO73_RS13835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHO73_RS13845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KHO73_RS13855	COG1228	amidohydrolase
KHO73_RS13865	COG2986	histidine ammonia-lyase
KHO73_RS13870	COG1309	transcriptional regulator
KHO73_RS13880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS13910	COG3250	beta-galactosidase activity
KHO73_RS13915	COG0667	Aldo Keto reductase
KHO73_RS14065	COG0531	amino acid
KHO73_RS14075	COG2066	Belongs to the glutaminase family
KHO73_RS14080	COG0076	glutamate decarboxylase activity
KHO73_RS14085	COG1595	DNA-templated transcription, initiation
KHO73_RS14105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KHO73_RS14115	COG1185	polyribonucleotide nucleotidyltransferase activity
KHO73_RS14130	COG1629	transport
KHO73_RS14130	COG4206	TonB-dependent receptor
KHO73_RS14155	COG3426	butyrate kinase activity
KHO73_RS14160	COG0280	phosphate acetyltransferase
KHO73_RS14170	COG1619	proteins homologs of microcin C7 resistance protein MccF
KHO73_RS14175	COG2234	aminopeptidase activity
KHO73_RS14180	COG2166	iron-sulfur cluster assembly
KHO73_RS14185	COG3655	Transcriptional regulator
KHO73_RS14195	COG1266	CAAX protease self-immunity
KHO73_RS14200	COG0196	riboflavin kinase activity
KHO73_RS14205	COG1011	Hydrolase
KHO73_RS14210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KHO73_RS14220	COG1773	rubredoxin
KHO73_RS14255	COG1629	transport
KHO73_RS14255	COG4206	TonB-dependent receptor
KHO73_RS14270	COG1283	sodium-dependent phosphate transmembrane transporter activity
KHO73_RS14285	COG3458	cephalosporin-C deacetylase activity
KHO73_RS14290	COG3408	Glycogen debranching enzyme
KHO73_RS14300	COG0006	proline dipeptidase activity
KHO73_RS14315	COG0509	glycine decarboxylation via glycine cleavage system
KHO73_RS14320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KHO73_RS14325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KHO73_RS14340	COG2217	Heavy metal translocating P-type atpase
KHO73_RS14350	COG0039	L-malate dehydrogenase activity
KHO73_RS14375	COG1629	transport
KHO73_RS14385	COG2996	Protein conserved in bacteria
KHO73_RS14405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KHO73_RS14415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KHO73_RS14415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KHO73_RS14425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS14430	COG0577	efflux transmembrane transporter activity
KHO73_RS14430	COG1136	(ABC) transporter
KHO73_RS14435	COG1136	(ABC) transporter
KHO73_RS14435	COG0577	efflux transmembrane transporter activity
KHO73_RS14440	COG0577	efflux transmembrane transporter activity
KHO73_RS14440	COG1136	(ABC) transporter
KHO73_RS14445	COG1940	carbohydrate kinase activity
KHO73_RS14460	COG0335	large ribosomal subunit rRNA binding
KHO73_RS14495	COG0737	Belongs to the 5'-nucleotidase family
KHO73_RS14500	COG0737	Belongs to the 5'-nucleotidase family
KHO73_RS14505	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO73_RS14530	COG0446	pyridine nucleotide-disulphide oxidoreductase
KHO73_RS14535	COG2204	response regulator
KHO73_RS14540	COG3250	beta-galactosidase activity
KHO73_RS14600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHO73_RS14605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KHO73_RS14610	COG1160	GTP binding
KHO73_RS14620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KHO73_RS14625	COG1127	ABC transporter
KHO73_RS14630	COG0724	RNA recognition motif
KHO73_RS14635	COG0544	peptidyl-prolyl cis-trans isomerase activity
KHO73_RS14640	COG0740	serine-type endopeptidase activity
KHO73_RS14645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KHO73_RS14650	COG0514	ATP-dependent DNA helicase (RecQ)
KHO73_RS14655	COG0516	GMP reductase activity
KHO73_RS14655	COG0517	IMP dehydrogenase activity
KHO73_RS14660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KHO73_RS14670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KHO73_RS14685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KHO73_RS14690	COG2885	chlorophyll binding
KHO73_RS14700	COG4771	TonB-dependent receptor
KHO73_RS14720	COG3537	Alpha-1,2-mannosidase
KHO73_RS14755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KHO73_RS14760	COG5433	transposase activity
KHO73_RS14770	COG3022	response to hydroperoxide
KHO73_RS14775	COG0110	maltose O-acetyltransferase activity
KHO73_RS14795	COG1187	pseudouridine synthase activity
KHO73_RS14800	COG0017	Asparaginyl-tRNA synthetase
KHO73_RS14810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KHO73_RS14815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KHO73_RS14820	COG0052	Belongs to the universal ribosomal protein uS2 family
KHO73_RS14825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KHO73_RS14840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KHO73_RS14845	COG0179	Fumarylacetoacetate (FAA) hydrolase
KHO73_RS14850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KHO73_RS14865	COG0482	sulfurtransferase activity
KHO73_RS14875	COG1570	exodeoxyribonuclease VII activity
KHO73_RS14885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KHO73_RS14895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KHO73_RS14900	COG0489	protein tyrosine kinase activity
KHO73_RS14905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KHO73_RS14935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS14955	COG0714	Associated with various cellular activities
KHO73_RS14960	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KHO73_RS14965	COG3552	Protein containing von Willebrand factor type A (VWA) domain
KHO73_RS14970	COG0039	L-malate dehydrogenase activity
KHO73_RS15005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KHO73_RS15010	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KHO73_RS15015	COG0811	peptide transport
KHO73_RS15020	COG0848	biopolymer transport protein
KHO73_RS15035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KHO73_RS15040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KHO73_RS15045	COG0105	UTP biosynthetic process
KHO73_RS15050	COG0739	heme binding
KHO73_RS15065	COG0149	triose-phosphate isomerase activity
KHO73_RS15075	COG0302	gtp cyclohydrolase
KHO73_RS15080	COG0358	DNA primase activity
KHO73_RS15090	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KHO73_RS15095	COG0436	Aminotransferase
KHO73_RS15110	COG0514	ATP-dependent DNA helicase (RecQ)
KHO73_RS15115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KHO73_RS15115	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KHO73_RS15130	COG0009	L-threonylcarbamoyladenylate synthase
KHO73_RS15140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KHO73_RS15145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KHO73_RS15150	COG2333	competence protein COMEC
KHO73_RS15150	COG0658	competence protein
KHO73_RS15155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KHO73_RS15165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KHO73_RS15175	COG4771	TonB-dependent receptor
KHO73_RS15180	COG0561	phosphatase activity
KHO73_RS15200	COG0745	RESPONSE REGULATOR receiver
KHO73_RS15200	COG2205	protein histidine kinase activity
KHO73_RS15200	COG3292	Two component regulator propeller
KHO73_RS15205	COG4771	TonB-dependent receptor
KHO73_RS15225	COG3537	Alpha-1,2-mannosidase
KHO73_RS15230	COG3537	Alpha-1,2-mannosidase
KHO73_RS15240	COG3537	Alpha-1,2-mannosidase
KHO73_RS15245	COG3279	Response regulator of the LytR AlgR family
KHO73_RS15250	COG3275	phosphorelay sensor kinase activity
KHO73_RS15255	COG1566	PFAM secretion protein HlyD family protein
KHO73_RS15270	COG0386	Belongs to the glutathione peroxidase family
KHO73_RS15275	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KHO73_RS15280	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KHO73_RS15320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KHO73_RS15415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KHO73_RS15430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KHO73_RS15435	COG0742	ribosomal rna small subunit methyltransferase
KHO73_RS15450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHO73_RS15455	COG4771	TonB-dependent receptor
KHO73_RS15490	COG3537	Alpha-1,2-mannosidase
KHO73_RS15495	COG3537	Alpha-1,2-mannosidase
KHO73_RS15515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KHO73_RS15520	COG0739	heme binding
KHO73_RS15530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KHO73_RS15535	COG0741	lytic transglycosylase activity
KHO73_RS15535	COG1388	LysM domain
KHO73_RS15545	COG1475	DNA binding
KHO73_RS15550	COG1192	Involved in chromosome partitioning
KHO73_RS15555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KHO73_RS15560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KHO73_RS15570	COG4589	Belongs to the CDS family
KHO73_RS15575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KHO73_RS15580	COG0799	negative regulation of ribosome biogenesis
KHO73_RS15590	COG0702	epimerase
KHO73_RS15595	COG1629	transport
KHO73_RS15595	COG4206	TonB-dependent receptor
KHO73_RS15600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS15600	COG3291	Pkd domain containing protein
KHO73_RS15605	COG1196	nuclear chromosome segregation
KHO73_RS15610	COG2239	Acts as a magnesium transporter
KHO73_RS15615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KHO73_RS15625	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHO73_RS15660	COG1119	ATPase activity
KHO73_RS15670	COG0668	transmembrane transport
KHO73_RS15675	COG2207	Transcriptional regulator
KHO73_RS15675	COG0662	Cupin 2, conserved barrel domain protein
KHO73_RS15700	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHO73_RS15705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KHO73_RS15710	COG0713	ATP synthesis coupled electron transport
KHO73_RS15725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KHO73_RS15730	COG0649	NAD binding
KHO73_RS15730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHO73_RS15735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHO73_RS15740	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KHO73_RS15775	COG3250	beta-galactosidase activity
KHO73_RS15785	COG3408	Glycogen debranching enzyme
KHO73_RS15790	COG3250	beta-galactosidase activity
KHO73_RS15795	COG3940	Belongs to the glycosyl hydrolase 43 family
KHO73_RS15805	COG0702	epimerase
KHO73_RS15820	COG4771	TonB-dependent receptor
KHO73_RS15825	COG0702	epimerase
KHO73_RS15830	COG4206	TonB-dependent receptor
KHO73_RS15830	COG1629	transport
KHO73_RS15850	COG3537	Alpha-1,2-mannosidase
KHO73_RS15860	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO73_RS15870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KHO73_RS15875	COG0569	domain protein
KHO73_RS15880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KHO73_RS15890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KHO73_RS15895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KHO73_RS15900	COG0805	protein transport
KHO73_RS15910	COG2271	Major facilitator Superfamily
KHO73_RS15915	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KHO73_RS15920	COG3775	system Galactitol-specific IIC component
KHO73_RS15935	COG2755	lipolytic protein G-D-S-L family
KHO73_RS15940	COG0745	RESPONSE REGULATOR receiver
KHO73_RS15940	COG2205	protein histidine kinase activity
KHO73_RS15940	COG3292	Two component regulator propeller
KHO73_RS15950	COG0702	epimerase
KHO73_RS15955	COG4771	TonB-dependent receptor
KHO73_RS15975	COG3279	Response regulator of the LytR AlgR family
KHO73_RS15990	COG1629	transport
KHO73_RS15990	COG4206	TonB-dependent receptor
KHO73_RS16005	COG2205	protein histidine kinase activity
KHO73_RS16005	COG0745	RESPONSE REGULATOR receiver
KHO73_RS16005	COG3292	Two component regulator propeller
KHO73_RS16010	COG1242	4 iron, 4 sulfur cluster binding
KHO73_RS16020	COG0363	glucosamine-6-phosphate deaminase activity
KHO73_RS16025	COG0009	L-threonylcarbamoyladenylate synthase
KHO73_RS16035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHO73_RS16040	COG0561	phosphatase activity
KHO73_RS16045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KHO73_RS16050	COG1408	metallophosphoesterase
KHO73_RS16080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KHO73_RS16100	COG3681	Belongs to the UPF0597 family
KHO73_RS16105	COG1047	Peptidyl-prolyl cis-trans
KHO73_RS16110	COG0129	dihydroxy-acid dehydratase activity
KHO73_RS16115	COG0028	Belongs to the TPP enzyme family
KHO73_RS16130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KHO73_RS16135	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KHO73_RS16140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KHO73_RS16145	COG0538	isocitrate dehydrogenase activity
KHO73_RS16150	COG0372	Belongs to the citrate synthase family
KHO73_RS16170	COG0205	6-phosphofructokinase activity
KHO73_RS16175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KHO73_RS16180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KHO73_RS16200	COG0084	hydrolase, TatD family'
KHO73_RS16210	COG0811	peptide transport
KHO73_RS16240	COG1522	sequence-specific DNA binding
KHO73_RS16250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KHO73_RS16265	COG1595	DNA-templated transcription, initiation
KHO73_RS16275	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KHO73_RS16275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KHO73_RS16305	COG0488	(ABC) transporter
KHO73_RS16310	COG0784	Response regulator, receiver
KHO73_RS16310	COG2205	protein histidine kinase activity
KHO73_RS16325	COG4771	TonB-dependent receptor
KHO73_RS16345	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS16375	COG2205	protein histidine kinase activity
KHO73_RS16395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KHO73_RS16405	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KHO73_RS16410	COG1088	dTDP-glucose 4,6-dehydratase activity
KHO73_RS16415	COG1575	Belongs to the MenA family. Type 1 subfamily
KHO73_RS16420	COG1408	metallophosphoesterase
KHO73_RS16425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KHO73_RS16435	COG0194	GDP metabolic process
KHO73_RS16455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KHO73_RS16460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KHO73_RS16470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KHO73_RS16475	COG0750	zinc metalloprotease
KHO73_RS16480	COG2814	Major facilitator Superfamily
KHO73_RS16485	COG0602	queuosine metabolic process
KHO73_RS16490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KHO73_RS16490	COG1328	CTP reductase activity
KHO73_RS16500	COG3328	transposase activity
KHO73_RS16530	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS16555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KHO73_RS16570	COG1272	protein, Hemolysin III
KHO73_RS16585	COG0673	inositol 2-dehydrogenase activity
KHO73_RS16590	COG0632	four-way junction helicase activity
KHO73_RS16610	COG0617	tRNA 3'-terminal CCA addition
KHO73_RS16615	COG0024	Methionine aminopeptidase
KHO73_RS16635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KHO73_RS16665	COG1538	Outer membrane efflux protein
KHO73_RS16720	COG2873	o-acetylhomoserine
KHO73_RS16730	COG2855	membrane
KHO73_RS16740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KHO73_RS16745	COG0511	ligase activity, forming carbon-carbon bonds
KHO73_RS16745	COG5016	pyruvate
KHO73_RS16750	COG0439	Biotin carboxylase
KHO73_RS16760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KHO73_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
KHO73_RS16795	COG1917	Cupin 2, conserved barrel domain protein
KHO73_RS16795	COG4977	sequence-specific DNA binding
KHO73_RS16805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KHO73_RS16815	COG0534	Mate efflux family protein
KHO73_RS16830	COG1704	LemA family
KHO73_RS16850	COG3973	AAA domain
KHO73_RS16865	COG0724	RNA recognition motif
KHO73_RS16870	COG2070	2-Nitropropane dioxygenase
KHO73_RS16875	COG0513	Belongs to the DEAD box helicase family
KHO73_RS16895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KHO73_RS16900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KHO73_RS16905	COG1663	tetraacyldisaccharide 4'-kinase activity
KHO73_RS16910	COG0616	signal peptide processing
KHO73_RS16930	COG4771	TonB-dependent receptor
KHO73_RS16935	COG0702	epimerase
KHO73_RS16940	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO73_RS16950	COG4948	Mandelate Racemase Muconate Lactonizing
KHO73_RS16985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KHO73_RS16990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KHO73_RS16995	COG0066	3-isopropylmalate dehydratase activity
KHO73_RS17005	COG0473	3-isopropylmalate dehydrogenase activity
KHO73_RS17020	COG0671	phosphoesterase, PA-phosphatase related
KHO73_RS17030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KHO73_RS17045	COG0514	ATP-dependent DNA helicase (RecQ)
KHO73_RS17070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KHO73_RS17085	COG0124	histidyl-tRNA synthetase
KHO73_RS17095	COG0823	Involved in the tonB-independent uptake of proteins
KHO73_RS17095	COG1506	peptidase
KHO73_RS17100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KHO73_RS17110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KHO73_RS17125	COG5002	protein histidine kinase activity
KHO73_RS17125	COG2205	protein histidine kinase activity
KHO73_RS17125	COG0784	Response regulator, receiver
KHO73_RS17140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KHO73_RS17145	COG0459	protein refolding
KHO73_RS17190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KHO73_RS17195	COG1120	ATPase activity
KHO73_RS17220	COG1192	Involved in chromosome partitioning
KHO73_RS17230	COG1629	transport
KHO73_RS17295	COG4974	Belongs to the 'phage' integrase family
KHO73_RS17300	COG4974	Belongs to the 'phage' integrase family
KHO73_RS17310	COG0717	Belongs to the dCTP deaminase family
KHO73_RS17320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KHO73_RS17330	COG2433	Pfam Transposase IS66
KHO73_RS17390	COG1475	DNA binding
KHO73_RS17480	COG1705	Flagellar rod assembly protein muramidase FlgJ
KHO73_RS17485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHO73_RS17555	COG0739	heme binding
KHO73_RS17575	COG0156	8-amino-7-oxononanoate synthase activity
KHO73_RS17585	COG1132	(ABC) transporter
KHO73_RS17680	COG3617	BRO family, N-terminal domain
KHO73_RS17795	COG2885	chlorophyll binding
KHO73_RS17815	COG0028	Belongs to the TPP enzyme family
KHO73_RS17850	COG2194	sulfuric ester hydrolase activity
KHO73_RS17855	COG0484	heat shock protein binding
KHO73_RS17865	COG1956	GAF domain-containing protein
KHO73_RS17885	COG1960	acyl-CoA dehydrogenase activity
KHO73_RS17890	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KHO73_RS17905	COG2205	protein histidine kinase activity
KHO73_RS17910	COG2205	protein histidine kinase activity
KHO73_RS17940	COG3279	Response regulator of the LytR AlgR family
KHO73_RS17975	COG0475	glutathione-regulated potassium exporter activity
KHO73_RS17990	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO73_RS18000	COG1472	Belongs to the glycosyl hydrolase 3 family
KHO73_RS18010	COG3250	beta-galactosidase activity
KHO73_RS18020	COG1629	transport
KHO73_RS18045	COG3537	Alpha-1,2-mannosidase
KHO73_RS18050	COG3250	beta-galactosidase activity
KHO73_RS18065	COG1621	beta-fructofuranosidase activity
KHO73_RS18075	COG1629	transport
KHO73_RS18075	COG4206	TonB-dependent receptor
KHO73_RS18080	COG0561	phosphatase activity
KHO73_RS18095	COG1621	beta-fructofuranosidase activity
KHO73_RS18105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KHO73_RS18105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KHO73_RS18115	COG0745	RESPONSE REGULATOR receiver
KHO73_RS18115	COG2205	protein histidine kinase activity
KHO73_RS18115	COG3292	Two component regulator propeller
KHO73_RS18135	COG4176	ABC-type proline glycine betaine transport system permease component
KHO73_RS18140	COG2113	Glycine betaine
KHO73_RS18165	COG1649	PFAM Uncharacterised BCR, COG1649
KHO73_RS18175	COG1966	Carbon starvation protein
KHO73_RS18200	COG1649	PFAM Uncharacterised BCR, COG1649
KHO73_RS18215	COG0745	RESPONSE REGULATOR receiver
KHO73_RS18215	COG0745	RESPONSE REGULATOR receiver
KHO73_RS18215	COG2205	protein histidine kinase activity
KHO73_RS18215	COG3292	Two component regulator propeller
KHO73_RS18215	COG2205	protein histidine kinase activity
KHO73_RS18215	COG3292	Two component regulator propeller
KHO73_RS18225	COG1280	lysine exporter protein (LysE YggA)
KHO73_RS18240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KHO73_RS18280	COG4750	Nucleotidyl transferase
KHO73_RS18305	COG3475	LICD family
KHO73_RS18325	COG1215	transferase activity, transferring glycosyl groups
KHO73_RS18330	COG3475	LICD family
KHO73_RS18400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KHO73_RS18405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS18410	COG0254	rRNA binding
KHO73_RS18415	COG0191	fructose-bisphosphate aldolase activity
KHO73_RS18425	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KHO73_RS18430	COG0511	ligase activity, forming carbon-carbon bonds
KHO73_RS18440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KHO73_RS18455	COG4771	TonB-dependent receptor
KHO73_RS18465	COG0288	reversible hydration of carbon dioxide
KHO73_RS18475	COG0778	Nitroreductase
KHO73_RS18495	COG0424	maF-like protein
KHO73_RS18515	COG0126	phosphoglycerate kinase activity
KHO73_RS18520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KHO73_RS18525	COG2814	Major facilitator Superfamily
KHO73_RS18530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KHO73_RS18545	COG0560	Phosphoserine phosphatase
KHO73_RS18560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KHO73_RS18565	COG1523	belongs to the glycosyl hydrolase 13 family
KHO73_RS18570	COG1119	ATPase activity
KHO73_RS18575	COG2205	protein histidine kinase activity
KHO73_RS18575	COG0784	Response regulator, receiver
KHO73_RS18580	COG0588	phosphoglycerate mutase activity
KHO73_RS18585	COG1830	Aldolase
KHO73_RS18590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KHO73_RS18620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KHO73_RS18635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHO73_RS18650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KHO73_RS18655	COG1028	Short-chain dehydrogenase reductase Sdr
KHO73_RS18660	COG3959	Transketolase, thiamine diphosphate binding domain
KHO73_RS18665	COG3958	Transketolase
KHO73_RS18685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KHO73_RS18700	COG1091	dTDP-4-dehydrorhamnose reductase activity
KHO73_RS18710	COG2244	polysaccharide biosynthetic process
KHO73_RS18775	COG3119	arylsulfatase activity
KHO73_RS18780	COG0745	RESPONSE REGULATOR receiver
KHO73_RS18780	COG2205	protein histidine kinase activity
KHO73_RS18780	COG3292	Two component regulator propeller
KHO73_RS18780	COG0745	RESPONSE REGULATOR receiver
KHO73_RS18780	COG2205	protein histidine kinase activity
KHO73_RS18780	COG3292	Two component regulator propeller
KHO73_RS18785	COG1660	Displays ATPase and GTPase activities
KHO73_RS18790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KHO73_RS18800	COG1629	transport
KHO73_RS18800	COG4206	TonB-dependent receptor
KHO73_RS18805	COG0702	epimerase
KHO73_RS18815	COG3119	arylsulfatase activity
KHO73_RS18820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS18825	COG3250	beta-galactosidase activity
KHO73_RS18835	COG3119	arylsulfatase activity
KHO73_RS18840	COG0668	transmembrane transport
KHO73_RS18845	COG3119	arylsulfatase activity
KHO73_RS18860	COG1629	transport
KHO73_RS18860	COG4206	TonB-dependent receptor
KHO73_RS18880	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHO73_RS18905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KHO73_RS18910	COG1983	PspC domain protein
KHO73_RS18925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KHO73_RS18930	COG1858	cytochrome C peroxidase
KHO73_RS18935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KHO73_RS18945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KHO73_RS18950	COG0534	Mate efflux family protein
KHO73_RS18955	COG2202	Pas domain
KHO73_RS18955	COG2205	protein histidine kinase activity
KHO73_RS18960	COG2205	protein histidine kinase activity
KHO73_RS18960	COG2202	Pas domain
KHO73_RS18965	COG3119	arylsulfatase activity
KHO73_RS18980	COG0037	tRNA processing
KHO73_RS18985	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KHO73_RS18985	COG1918	ferrous iron import across plasma membrane
KHO73_RS19020	COG0456	acetyltransferase
KHO73_RS19075	COG0259	pyridoxamine-phosphate oxidase activity
KHO73_RS19080	COG1741	Belongs to the pirin family
KHO73_RS19085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KHO73_RS19100	COG1595	DNA-templated transcription, initiation
KHO73_RS19130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KHO73_RS19140	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KHO73_RS19150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KHO73_RS19195	COG0686	Belongs to the AlaDH PNT family
KHO73_RS19205	COG1629	transport
KHO73_RS19205	COG4206	TonB-dependent receptor
KHO73_RS19210	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KHO73_RS19215	COG0739	heme binding
KHO73_RS19240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KHO73_RS19265	COG0488	(ABC) transporter
KHO73_RS19270	COG3250	beta-galactosidase activity
KHO73_RS19280	COG3292	Two component regulator propeller
KHO73_RS19280	COG2205	protein histidine kinase activity
KHO73_RS19280	COG0745	RESPONSE REGULATOR receiver
KHO73_RS19285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KHO73_RS19290	COG3059	membrane
KHO73_RS19305	COG1705	Flagellar rod assembly protein muramidase FlgJ
KHO73_RS19310	COG1252	NADH dehydrogenase
KHO73_RS19320	COG1136	(ABC) transporter
KHO73_RS19335	COG0577	efflux transmembrane transporter activity
KHO73_RS19335	COG1136	(ABC) transporter
KHO73_RS19340	COG2205	protein histidine kinase activity
KHO73_RS19340	COG5002	protein histidine kinase activity
KHO73_RS19340	COG0784	Response regulator, receiver
KHO73_RS19350	COG2204	response regulator
KHO73_RS19355	COG4191	Histidine kinase
KHO73_RS19370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KHO73_RS19380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KHO73_RS19400	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS19415	COG0305	Participates in initiation and elongation during chromosome replication
KHO73_RS19445	COG2885	chlorophyll binding
KHO73_RS19460	COG2885	chlorophyll binding
KHO73_RS19465	COG1530	ribonuclease E activity
KHO73_RS19475	COG1194	a g-specific adenine glycosylase
KHO73_RS19480	COG0629	single-stranded DNA binding
KHO73_RS19505	COG3033	Beta-eliminating lyase
KHO73_RS19550	COG5002	protein histidine kinase activity
KHO73_RS19555	COG0745	RESPONSE REGULATOR receiver
KHO73_RS19570	COG0488	(ABC) transporter
KHO73_RS19585	COG0436	Aminotransferase
KHO73_RS19590	COG1136	(ABC) transporter
KHO73_RS19590	COG0577	efflux transmembrane transporter activity
KHO73_RS19595	COG0569	domain protein
KHO73_RS19595	COG0189	ligase activity
KHO73_RS19605	COG1215	transferase activity, transferring glycosyl groups
KHO73_RS19610	COG0628	permease
KHO73_RS19620	COG2204	response regulator
KHO73_RS19635	COG0577	efflux transmembrane transporter activity
KHO73_RS19635	COG1136	(ABC) transporter
KHO73_RS19640	COG0577	efflux transmembrane transporter activity
KHO73_RS19650	COG0110	maltose O-acetyltransferase activity
KHO73_RS19690	COG1690	Belongs to the RtcB family
KHO73_RS19695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KHO73_RS19700	COG1620	l-lactate permease
KHO73_RS19715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KHO73_RS19720	COG0439	Biotin carboxylase
KHO73_RS19725	COG0511	ligase activity, forming carbon-carbon bonds
KHO73_RS19730	COG5002	protein histidine kinase activity
KHO73_RS19730	COG0784	Response regulator, receiver
KHO73_RS19740	COG2226	methyltransferase
KHO73_RS19755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KHO73_RS19755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KHO73_RS19765	COG4771	TonB-dependent receptor
KHO73_RS19775	COG2223	nitrite transmembrane transporter activity
KHO73_RS19780	COG1929	Belongs to the glycerate kinase type-1 family
KHO73_RS19795	COG1609	Transcriptional regulator
KHO73_RS19800	COG1028	Short-chain dehydrogenase reductase Sdr
KHO73_RS19805	COG1312	Catalyzes the dehydration of D-mannonate
KHO73_RS19865	COG4771	TonB-dependent receptor
KHO73_RS19880	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KHO73_RS19890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KHO73_RS19905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KHO73_RS19910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KHO73_RS19920	COG4946	Tricorn protease homolog
KHO73_RS19920	COG0823	Involved in the tonB-independent uptake of proteins
KHO73_RS19920	COG1506	peptidase
KHO73_RS19925	COG3328	transposase activity
KHO73_RS19940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KHO73_RS19955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KHO73_RS19985	COG3546	catalase activity
KHO73_RS20015	COG2885	chlorophyll binding
KHO73_RS20015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KHO73_RS20030	COG2076	Multidrug Resistance protein
KHO73_RS20035	COG0534	Mate efflux family protein
KHO73_RS20055	COG0656	L-ascorbic acid biosynthetic process
KHO73_RS20060	COG0693	protein deglycase activity
KHO73_RS20075	COG0788	formyltetrahydrofolate deformylase activity
KHO73_RS20080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KHO73_RS20085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KHO73_RS20090	COG0107	imidazoleglycerol-phosphate synthase activity
KHO73_RS20095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KHO73_RS20095	COG0140	phosphoribosyl-ATP diphosphatase activity
KHO73_RS20100	COG2884	Cell division ATP-binding protein ftsE
KHO73_RS20105	COG0527	aspartate kinase activity
KHO73_RS20110	COG0019	diaminopimelate decarboxylase activity
KHO73_RS20125	COG0156	8-amino-7-oxononanoate synthase activity
KHO73_RS20130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KHO73_RS20140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KHO73_RS20145	COG0321	lipoyl(octanoyl) transferase activity
KHO73_RS20145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KHO73_RS20160	COG0592	DNA-directed DNA polymerase activity
KHO73_RS20175	COG0497	DNA recombination
KHO73_RS20180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHO73_RS20240	COG1442	glycosyl transferase family 8
KHO73_RS20240	COG1216	Glycosyl transferase, family 2
KHO73_RS20275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KHO73_RS20280	COG0167	dihydroorotate dehydrogenase activity
KHO73_RS20285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KHO73_RS20300	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KHO73_RS20310	COG0586	Pfam SNARE associated Golgi protein
KHO73_RS20320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KHO73_RS20330	COG0573	inorganic phosphate transmembrane transporter activity
KHO73_RS20335	COG0581	inorganic phosphate transmembrane transporter activity
KHO73_RS20340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KHO73_RS20345	COG0704	Plays a role in the regulation of phosphate uptake
KHO73_RS20375	COG0582	viral genome integration into host DNA
KHO73_RS20405	COG1295	ribonuclease BN
KHO73_RS20420	COG4948	Mandelate Racemase Muconate Lactonizing
KHO73_RS20425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KHO73_RS20430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KHO73_RS20490	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KHO73_RS20510	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KHO73_RS20520	COG0058	SHG alpha-glucan phosphorylase activity
KHO73_RS20525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KHO73_RS20530	COG3842	ATPase activity
KHO73_RS20535	COG1176	ABC-type spermidine putrescine transport system, permease component I
KHO73_RS20540	COG1177	transmembrane transport
KHO73_RS20560	COG2207	Transcriptional regulator
KHO73_RS20605	COG0738	Major facilitator superfamily
KHO73_RS20615	COG1070	Carbohydrate kinase
KHO73_RS20625	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
KHO73_RS20630	COG2188	Transcriptional regulator
KHO73_RS20635	COG0228	four-way junction DNA binding
KHO73_RS20660	COG3275	phosphorelay sensor kinase activity
KHO73_RS20670	COG0784	Response regulator, receiver
KHO73_RS20670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHO73_RS20670	COG2198	Histidine kinase
KHO73_RS20670	COG2205	protein histidine kinase activity
KHO73_RS20680	COG1733	regulation of RNA biosynthetic process
KHO73_RS20760	COG2721	sulfolactate sulfo-lyase activity
KHO73_RS20765	COG1609	Transcriptional regulator
KHO73_RS20805	COG4771	TonB-dependent receptor
KHO73_RS20820	COG1230	cation diffusion facilitator family transporter
KHO73_RS20825	COG0490	domain, Protein
KHO73_RS20825	COG2985	domain, Protein
KHO73_RS20835	COG4771	TonB-dependent receptor
KHO73_RS20845	COG4771	TonB-dependent receptor
KHO73_RS21005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHO73_RS21065	COG0739	heme binding
KHO73_RS21065	COG1196	nuclear chromosome segregation
KHO73_RS21065	COG0741	lytic transglycosylase activity
KHO73_RS21070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KHO73_RS21120	COG3344	reverse transcriptase
KHO73_RS21165	COG3209	COG3209 Rhs family protein
KHO73_RS21175	COG3209	COG3209 Rhs family protein
KHO73_RS21240	COG0542	response to heat
KHO73_RS21280	COG0629	single-stranded DNA binding
KHO73_RS21285	COG1192	Involved in chromosome partitioning
KHO73_RS21305	COG1475	DNA binding
KHO73_RS21455	COG4974	Belongs to the 'phage' integrase family
KHO73_RS21465	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS21480	COG1132	(ABC) transporter
KHO73_RS21495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KHO73_RS21495	COG1333	cytochrome c biogenesis protein
KHO73_RS21510	COG3746	phosphate-selective porin O and P
KHO73_RS21520	COG3487	Iron-regulated protein
KHO73_RS21540	COG0716	FMN binding
KHO73_RS21550	COG0138	bifunctional purine biosynthesis protein purh
KHO73_RS21560	COG2197	response regulator
KHO73_RS21565	COG0110	maltose O-acetyltransferase activity
KHO73_RS21575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KHO73_RS21580	COG3292	Two component regulator propeller
KHO73_RS21580	COG2205	protein histidine kinase activity
KHO73_RS21580	COG0745	RESPONSE REGULATOR receiver
KHO73_RS21590	COG0252	asparaginase activity
KHO73_RS21595	COG0159	tryptophan synthase activity
KHO73_RS21600	COG0135	phosphoribosylanthranilate isomerase activity
KHO73_RS21605	COG0134	indole-3-glycerol-phosphate synthase activity
KHO73_RS21610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KHO73_RS21620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KHO73_RS21625	COG0133	tryptophan synthase activity
KHO73_RS21635	COG1979	alcohol dehydrogenase
KHO73_RS21645	COG0471	metal ion transport
KHO73_RS21645	COG0490	domain, Protein
KHO73_RS21650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KHO73_RS21670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KHO73_RS21685	COG0004	ammonium transporteR
KHO73_RS21690	COG0347	Belongs to the P(II) protein family
KHO73_RS21700	COG0436	Aminotransferase
KHO73_RS21705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KHO73_RS21720	COG0367	asparagine synthase
KHO73_RS21730	COG0067	glutamate synthase
KHO73_RS21730	COG0069	glutamate synthase activity
KHO73_RS21730	COG0070	glutamate synthase
KHO73_RS21735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KHO73_RS21745	COG0505	Belongs to the CarA family
KHO73_RS21750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KHO73_RS21760	COG1917	Cupin 2, conserved barrel domain protein
KHO73_RS21760	COG2207	Transcriptional regulator
KHO73_RS21775	COG1131	(ABC) transporter
KHO73_RS21780	COG0842	Transport permease protein
KHO73_RS21785	COG0842	Transport permease protein
KHO73_RS21795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KHO73_RS21800	COG2949	membrane
KHO73_RS21815	COG0556	nucleotide-excision repair
KHO73_RS21820	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KHO73_RS21850	COG3942	CHAP domain
KHO73_RS21850	COG1388	LysM domain
KHO73_RS21860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KHO73_RS21865	COG3104	oligopeptide transport
KHO73_RS21875	COG1695	Transcriptional regulator
KHO73_RS21880	COG1983	PspC domain protein
KHO73_RS21900	COG0823	Involved in the tonB-independent uptake of proteins
KHO73_RS21900	COG1506	peptidase
KHO73_RS21905	COG0534	Mate efflux family protein
KHO73_RS21910	COG0706	membrane insertase activity
KHO73_RS21915	COG0504	CTP synthase activity
KHO73_RS21970	COG1086	Polysaccharide biosynthesis protein
KHO73_RS21990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KHO73_RS22115	COG4656	Part of a membrane complex involved in electron transport
KHO73_RS22120	COG4658	electron transport chain
KHO73_RS22125	COG4659	FMN binding
KHO73_RS22130	COG4660	Part of a membrane complex involved in electron transport
KHO73_RS22135	COG4657	Part of a membrane complex involved in electron transport
KHO73_RS22140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KHO73_RS22145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KHO73_RS22150	COG0305	Participates in initiation and elongation during chromosome replication
KHO73_RS22155	COG0072	phenylalanine-tRNA ligase activity
KHO73_RS22155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHO73_RS22160	COG0217	transcriptional regulatory protein
KHO73_RS22175	COG0708	Exodeoxyribonuclease III
KHO73_RS22190	COG0481	GTPase activity
KHO73_RS22200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KHO73_RS22220	COG0024	Methionine aminopeptidase
KHO73_RS22240	COG0564	pseudouridine synthase activity
KHO73_RS22245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KHO73_RS22250	COG0574	Belongs to the PEP-utilizing enzyme family
KHO73_RS22250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KHO73_RS22265	COG0352	thiamine-phosphate diphosphorylase activity
KHO73_RS22270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KHO73_RS22275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KHO73_RS22280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KHO73_RS22285	COG2022	thiamine diphosphate biosynthetic process
KHO73_RS22290	COG0352	thiamine-phosphate diphosphorylase activity
KHO73_RS22300	COG3437	response regulator, receiver
KHO73_RS22300	COG3850	Histidine kinase
KHO73_RS22300	COG2205	protein histidine kinase activity
KHO73_RS22300	COG4999	Histidine kinase
KHO73_RS22315	COG0210	DNA helicase
KHO73_RS22370	COG0681	Belongs to the peptidase S26 family
KHO73_RS22380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS22400	COG2249	NAD(P)H dehydrogenase (quinone) activity
KHO73_RS22445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KHO73_RS22450	COG3118	belongs to the thioredoxin family
KHO73_RS22470	COG5002	protein histidine kinase activity
KHO73_RS22475	COG0745	RESPONSE REGULATOR receiver
KHO73_RS22480	COG1082	Xylose isomerase domain protein TIM barrel
KHO73_RS22485	COG0318	PFAM AMP-dependent synthetase and ligase
KHO73_RS22490	COG3263	regulation of cellular component size
KHO73_RS22495	COG2233	PERMEase
KHO73_RS22500	COG1151	hydroxylamine reductase activity
KHO73_RS22535	COG1136	(ABC) transporter
KHO73_RS22545	COG0534	Mate efflux family protein
KHO73_RS22555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KHO73_RS22565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KHO73_RS22585	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KHO73_RS22600	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS22625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KHO73_RS22630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KHO73_RS22640	COG0356	it plays a direct role in the translocation of protons across the membrane
KHO73_RS22645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KHO73_RS22650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KHO73_RS22655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KHO73_RS22660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KHO73_RS22665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KHO73_RS22675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHO73_RS22680	COG2431	L-lysine efflux transmembrane transporter activity
KHO73_RS22705	COG2207	Transcriptional regulator
KHO73_RS22745	COG2985	domain, Protein
KHO73_RS22750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KHO73_RS22755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KHO73_RS22770	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
KHO73_RS22775	COG0540	Belongs to the ATCase OTCase family
KHO73_RS22790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KHO73_RS22805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KHO73_RS22810	COG2205	protein histidine kinase activity
KHO73_RS22835	COG4206	TonB-dependent receptor
KHO73_RS22835	COG1629	transport
KHO73_RS22845	COG3119	arylsulfatase activity
KHO73_RS22850	COG3250	beta-galactosidase activity
KHO73_RS22855	COG3153	acetyltransferase
KHO73_RS22905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KHO73_RS22910	COG1214	PFAM Peptidase M22, glycoprotease
KHO73_RS22910	COG0456	acetyltransferase
KHO73_RS22920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KHO73_RS22925	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KHO73_RS22930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KHO73_RS22945	COG2205	protein histidine kinase activity
KHO73_RS22945	COG3292	Two component regulator propeller
KHO73_RS22945	COG0745	RESPONSE REGULATOR receiver
KHO73_RS22980	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS23005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KHO73_RS23015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KHO73_RS23020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KHO73_RS23035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KHO73_RS23060	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
KHO73_RS23070	COG2326	polyphosphate kinase activity
KHO73_RS23105	COG3279	Response regulator of the LytR AlgR family
KHO73_RS23110	COG0724	RNA recognition motif
KHO73_RS23135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KHO73_RS23140	COG0045	succinate-CoA ligase (ADP-forming) activity
KHO73_RS23145	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KHO73_RS23150	COG0351	phosphomethylpyrimidine kinase
KHO73_RS23165	COG2115	Belongs to the xylose isomerase family
KHO73_RS23170	COG2814	Major facilitator Superfamily
KHO73_RS23170	COG0477	Major facilitator Superfamily
KHO73_RS23175	COG3153	acetyltransferase
KHO73_RS23175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KHO73_RS23185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KHO73_RS23195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KHO73_RS23205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHO73_RS23235	COG3015	lipoprotein NlpE involved in copper resistance
KHO73_RS23240	COG0784	Response regulator, receiver
KHO73_RS23240	COG2198	Histidine kinase
KHO73_RS23240	COG2205	protein histidine kinase activity
KHO73_RS23260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KHO73_RS23275	COG4974	Belongs to the 'phage' integrase family
KHO73_RS23355	COG0587	DNA-directed DNA polymerase activity
KHO73_RS23360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHO73_RS23365	COG0587	DNA-directed DNA polymerase activity
KHO73_RS23590	COG0756	dUTP diphosphatase activity
KHO73_RS23595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KHO73_RS23635	COG0484	heat shock protein binding
KHO73_RS23935	COG1904	glucuronate isomerase
KHO73_RS23940	COG1609	Transcriptional regulator
KHO73_RS23945	COG0246	Mannitol dehydrogenase
KHO73_RS23975	COG0513	Belongs to the DEAD box helicase family
KHO73_RS23980	COG3830	Belongs to the UPF0237 family
KHO73_RS23980	COG0560	Phosphoserine phosphatase
KHO73_RS24000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KHO73_RS24005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KHO73_RS24020	COG2433	Pfam Transposase IS66
KHO73_RS24155	COG3328	transposase activity
KHO73_RS24180	COG0302	gtp cyclohydrolase
KHO73_RS24185	COG0602	queuosine metabolic process
KHO73_RS24245	COG0592	DNA-directed DNA polymerase activity
KHO73_RS24265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KHO73_RS24275	COG3852	Histidine kinase
KHO73_RS24300	COG1136	(ABC) transporter
KHO73_RS24335	COG4771	TonB-dependent receptor
KHO73_RS24350	COG0156	8-amino-7-oxononanoate synthase activity
KHO73_RS24355	COG1597	lipid kinase activity
KHO73_RS24360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KHO73_RS24390	COG1132	(ABC) transporter
KHO73_RS24410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KHO73_RS24440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KHO73_RS24455	COG0543	2 iron, 2 sulfur cluster binding
KHO73_RS24460	COG0167	dihydroorotate dehydrogenase activity
KHO73_RS24465	COG0336	Belongs to the RNA methyltransferase TrmD family
KHO73_RS24470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KHO73_RS24475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KHO73_RS24500	COG0326	Molecular chaperone. Has ATPase activity
KHO73_RS24550	COG2304	oxidoreductase activity
KHO73_RS24565	COG0714	Associated with various cellular activities
KHO73_RS24570	COG0776	regulation of translation
KHO73_RS24575	COG0776	regulation of translation
KHO73_RS24580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KHO73_RS24585	COG0552	protein localization to endoplasmic reticulum
KHO73_RS24595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KHO73_RS24600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KHO73_RS24610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KHO73_RS24645	COG2205	protein histidine kinase activity
KHO73_RS24650	COG0745	RESPONSE REGULATOR receiver
KHO73_RS24655	COG0442	prolyl-tRNA aminoacylation
KHO73_RS24670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS24685	COG0745	RESPONSE REGULATOR receiver
KHO73_RS24685	COG2205	protein histidine kinase activity
KHO73_RS24685	COG3292	Two component regulator propeller
KHO73_RS24730	COG1595	DNA-templated transcription, initiation
KHO73_RS24750	COG1011	Hydrolase
KHO73_RS24760	COG0300	oxidoreductase activity
KHO73_RS24765	COG4974	Belongs to the 'phage' integrase family
KHO73_RS24840	COG0739	heme binding
KHO73_RS24905	COG2205	protein histidine kinase activity
KHO73_RS24905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHO73_RS24905	COG2198	Histidine kinase
KHO73_RS24905	COG0784	Response regulator, receiver
KHO73_RS24915	COG0010	Belongs to the arginase family
KHO73_RS24920	COG0058	SHG alpha-glucan phosphorylase activity
KHO73_RS24925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KHO73_RS24925	COG4651	solute:proton antiporter activity
KHO73_RS24930	COG0205	6-phosphofructokinase activity
KHO73_RS24945	COG0588	phosphoglycerate mutase activity
KHO73_RS24950	COG1830	Aldolase
KHO73_RS24960	COG2095	MarC family integral membrane protein
KHO73_RS25000	COG2205	protein histidine kinase activity
KHO73_RS25000	COG3292	Two component regulator propeller
KHO73_RS25000	COG0745	RESPONSE REGULATOR receiver
KHO73_RS25005	COG1629	transport
KHO73_RS25010	COG0702	epimerase
KHO73_RS25055	COG0745	RESPONSE REGULATOR receiver
KHO73_RS25055	COG2205	protein histidine kinase activity
KHO73_RS25055	COG3292	Two component regulator propeller
KHO73_RS25055	COG0745	RESPONSE REGULATOR receiver
KHO73_RS25055	COG2205	protein histidine kinase activity
KHO73_RS25055	COG3292	Two component regulator propeller
KHO73_RS25190	COG3015	lipoprotein NlpE involved in copper resistance
KHO73_RS25240	COG0428	transporter
KHO73_RS25250	COG1132	(ABC) transporter
KHO73_RS25250	COG2375	cellular response to nickel ion
KHO73_RS25255	COG1132	(ABC) transporter
KHO73_RS25275	COG4771	TonB-dependent receptor
KHO73_RS25300	COG0622	Phosphoesterase
KHO73_RS25445	COG2433	Pfam Transposase IS66
KHO73_RS25470	COG2966	Psort location CytoplasmicMembrane, score
KHO73_RS25500	COG2205	protein histidine kinase activity
KHO73_RS25500	COG3292	Two component regulator propeller
KHO73_RS25500	COG0745	RESPONSE REGULATOR receiver
KHO73_RS25505	COG3250	beta-galactosidase activity
KHO73_RS25535	COG5002	protein histidine kinase activity
KHO73_RS25540	COG0745	RESPONSE REGULATOR receiver
KHO73_RS25545	COG3250	beta-galactosidase activity
KHO73_RS25565	COG3250	beta-galactosidase activity
KHO73_RS25625	COG2755	lipolytic protein G-D-S-L family
KHO73_RS25625	COG0657	acetylesterase activity
KHO73_RS25630	COG0167	dihydroorotate dehydrogenase activity
KHO73_RS25640	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KHO73_RS25645	COG3408	Glycogen debranching enzyme
KHO73_RS25655	COG1028	Short-chain dehydrogenase reductase Sdr
KHO73_RS25675	COG3408	Glycogen debranching enzyme
KHO73_RS25700	COG0702	epimerase
KHO73_RS25705	COG1629	transport
KHO73_RS25705	COG4206	TonB-dependent receptor
KHO73_RS25720	COG3537	Alpha-1,2-mannosidase
KHO73_RS25725	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KHO73_RS25760	COG4771	TonB-dependent receptor
KHO73_RS25830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KHO73_RS25830	COG0551	DNA topoisomerase type I activity
KHO73_RS25840	COG4974	Belongs to the 'phage' integrase family
KHO73_RS25925	COG3344	reverse transcriptase
KHO73_RS26065	COG2003	Belongs to the UPF0758 family
KHO73_RS26075	COG1475	DNA binding
KHO73_RS26170	COG4974	Belongs to the 'phage' integrase family
KHO73_RS26195	COG4206	TonB-dependent receptor
KHO73_RS26195	COG1629	transport
KHO73_RS26220	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS26240	COG1074	ATP-dependent DNA helicase activity
KHO73_RS26245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KHO73_RS26310	COG1475	DNA binding
KHO73_RS26315	COG3969	phosphoadenosine phosphosulfate
KHO73_RS26345	COG3275	phosphorelay sensor kinase activity
KHO73_RS26365	COG1678	Uncharacterized ACR, COG1678
KHO73_RS26380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KHO73_RS26390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KHO73_RS26420	COG0321	lipoyl(octanoyl) transferase activity
KHO73_RS26430	COG2217	Heavy metal translocating P-type atpase
KHO73_RS26460	COG0357	Ribosomal RNA small subunit methyltransferase G
KHO73_RS26465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KHO73_RS26470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KHO73_RS26470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KHO73_RS26475	COG0778	Nitroreductase
KHO73_RS26485	COG1739	Uncharacterized protein family UPF0029
KHO73_RS26500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KHO73_RS26505	COG0513	Belongs to the DEAD box helicase family
KHO73_RS26510	COG2871	sodium ion transport
KHO73_RS26515	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KHO73_RS26525	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KHO73_RS26530	COG1805	sodium ion transport
KHO73_RS26565	COG1215	transferase activity, transferring glycosyl groups
KHO73_RS26575	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS26615	COG1216	Glycosyl transferase, family 2
KHO73_RS26615	COG1442	glycosyl transferase family 8
KHO73_RS26620	COG2244	polysaccharide biosynthetic process
KHO73_RS26630	COG1442	glycosyl transferase family 8
KHO73_RS26635	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS26640	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS26645	COG1216	Glycosyl transferase, family 2
KHO73_RS26645	COG1442	glycosyl transferase family 8
KHO73_RS26675	COG0488	(ABC) transporter
KHO73_RS26695	COG1162	GTPase activity
KHO73_RS26705	COG0657	acetylesterase activity
KHO73_RS26705	COG2755	lipolytic protein G-D-S-L family
KHO73_RS26710	COG0534	Mate efflux family protein
KHO73_RS26715	COG2885	chlorophyll binding
KHO73_RS26720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KHO73_RS26735	COG1704	LemA family
KHO73_RS26740	COG0501	Belongs to the peptidase M48B family
KHO73_RS26765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KHO73_RS26775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KHO73_RS26800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KHO73_RS26805	COG1136	(ABC) transporter
KHO73_RS26810	COG0577	efflux transmembrane transporter activity
KHO73_RS26810	COG1136	(ABC) transporter
KHO73_RS26820	COG3279	Response regulator of the LytR AlgR family
KHO73_RS26825	COG2135	peptidase activity
KHO73_RS26830	COG2837	iron assimilation
KHO73_RS26840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KHO73_RS26850	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KHO73_RS26855	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KHO73_RS26860	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KHO73_RS26865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KHO73_RS26870	COG0318	PFAM AMP-dependent synthetase and ligase
KHO73_RS26880	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
KHO73_RS26885	COG2985	domain, Protein
KHO73_RS26885	COG0490	domain, Protein
KHO73_RS26925	COG0737	Belongs to the 5'-nucleotidase family
KHO73_RS26930	COG2205	protein histidine kinase activity
KHO73_RS26930	COG2202	Pas domain
KHO73_RS26935	COG2183	response to ionizing radiation
KHO73_RS26980	COG3023	N-Acetylmuramoyl-L-alanine amidase
KHO73_RS27005	COG0488	(ABC) transporter
KHO73_RS27010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KHO73_RS27015	COG0484	heat shock protein binding
KHO73_RS27020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KHO73_RS27025	COG4771	TonB-dependent receptor
KHO73_RS27050	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS27055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KHO73_RS27060	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS27075	COG0438	transferase activity, transferring glycosyl groups
KHO73_RS27085	COG1216	Glycosyl transferase, family 2
KHO73_RS27085	COG1442	glycosyl transferase family 8
KHO73_RS27120	COG3250	beta-galactosidase activity
KHO73_RS27125	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS27130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS27140	COG0657	acetylesterase activity
KHO73_RS27140	COG2755	lipolytic protein G-D-S-L family
KHO73_RS27145	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KHO73_RS27235	COG0739	heme binding
KHO73_RS27235	COG0741	lytic transglycosylase activity
KHO73_RS27235	COG1196	nuclear chromosome segregation
KHO73_RS27305	COG1192	Involved in chromosome partitioning
KHO73_RS27320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KHO73_RS27325	COG3177	Filamentation induced by cAMP protein fic
KHO73_RS27400	COG2201	protein-glutamate methylesterase activity
KHO73_RS27470	COG3507	Belongs to the glycosyl hydrolase 43 family
KHO73_RS27605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KHO73_RS27615	COG0110	maltose O-acetyltransferase activity
KHO73_RS27640	COG3935	DnaD domain protein
KHO73_RS27655	COG2433	Pfam Transposase IS66
KHO73_RS27660	COG4372	Transposase