locus-tag	class	description
BT_0005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BT_0014	COG5002	protein histidine kinase activity
BT_0014	COG2198	Histidine kinase
BT_0014	COG0784	Response regulator, receiver
BT_0024	COG3328	transposase activity
BT_0029	COG1629	transport
BT_0029	COG4206	TonB-dependent receptor
BT_0044	COG1442	glycosyl transferase family 8
BT_0044	COG1216	Glycosyl transferase, family 2
BT_0046	COG1215	transferase activity, transferring glycosyl groups
BT_0047	COG1216	Glycosyl transferase, family 2
BT_0050	COG1216	Glycosyl transferase, family 2
BT_0050	COG1442	glycosyl transferase family 8
BT_0051	COG1216	Glycosyl transferase, family 2
BT_0054	COG0438	transferase activity, transferring glycosyl groups
BT_0055	COG0438	transferase activity, transferring glycosyl groups
BT_0056	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BT_0066	COG2885	chlorophyll binding
BT_0072	COG4988	ABC transporter
BT_0073	COG1132	(ABC) transporter
BT_0076	COG4974	Belongs to the 'phage' integrase family
BT_0078	COG2003	Belongs to the UPF0758 family
BT_0105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BT_0105	COG0551	DNA topoisomerase type I activity
BT_0114	COG0798	PFAM Bile acid sodium symporter
BT_0115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BT_0122	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BT_0130	COG1028	Short-chain dehydrogenase reductase Sdr
BT_0131	COG3385	transposase activity
BT_0132	COG1082	Xylose isomerase domain protein TIM barrel
BT_0133	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BT_0138	COG3292	Two component regulator propeller
BT_0138	COG2205	protein histidine kinase activity
BT_0138	COG0745	RESPONSE REGULATOR receiver
BT_0138	COG2205	protein histidine kinase activity
BT_0138	COG0745	RESPONSE REGULATOR receiver
BT_0138	COG3292	Two component regulator propeller
BT_0139	COG1595	DNA-templated transcription, initiation
BT_0140	COG1629	transport
BT_0140	COG4206	TonB-dependent receptor
BT_0142	COG5492	domain, Protein
BT_0146	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BT_0148	COG1253	flavin adenine dinucleotide binding
BT_0149	COG0501	Belongs to the peptidase M48B family
BT_0154	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BT_0155	COG0482	sulfurtransferase activity
BT_0156	COG2197	response regulator
BT_0158	COG1757	Na H antiporter
BT_0161	COG2814	Major facilitator Superfamily
BT_0162	COG4953	penicillin-binding protein 1C
BT_0164	COG2373	Large extracellular alpha-helical protein
BT_0165	COG0545	Peptidyl-prolyl cis-trans isomerase
BT_0179	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BT_0180	COG1410	methionine synthase
BT_0180	COG0646	methionine synthase
BT_0181	COG0778	Nitroreductase
BT_0182	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BT_0184	COG0572	uridine kinase
BT_0186	COG4232	protein-disulfide reductase activity
BT_0187	COG1741	Belongs to the pirin family
BT_0190	COG4771	TonB-dependent receptor
BT_0191	COG0702	epimerase
BT_0196	COG2271	Major facilitator Superfamily
BT_0200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BT_0201	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BT_0202	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BT_0203	COG0131	Imidazoleglycerol-phosphate dehydratase
BT_0205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BT_0205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BT_0206	COG1629	transport
BT_0206	COG4206	TonB-dependent receptor
BT_0216	COG1773	rubredoxin
BT_0216	COG1592	Rubrerythrin
BT_0221	COG1373	ATPase (AAA superfamily
BT_0223	COG3279	Response regulator of the LytR AlgR family
BT_0233	COG4974	Belongs to the 'phage' integrase family
BT_0236	COG3591	Belongs to the peptidase S1B family
BT_0237	COG3591	Belongs to the peptidase S1B family
BT_0238	COG0641	radical SAM
BT_0244	COG0420	3'-5' exonuclease activity
BT_0246	COG1408	metallophosphoesterase
BT_0249	COG1410	methionine synthase
BT_0249	COG0646	methionine synthase
BT_0251	COG0463	Glycosyl transferase, family 2
BT_0252	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BT_0254	COG1032	radical SAM domain protein
BT_0258	COG0363	glucosamine-6-phosphate deaminase activity
BT_0259	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BT_0267	COG2205	protein histidine kinase activity
BT_0267	COG0745	RESPONSE REGULATOR receiver
BT_0267	COG3292	Two component regulator propeller
BT_0268	COG1629	transport
BT_0269	COG0702	epimerase
BT_0272	COG4771	TonB-dependent receptor
BT_0280	COG3328	transposase activity
BT_0285	COG0811	peptide transport
BT_0286	COG0848	biopolymer transport protein
BT_0295	COG1131	(ABC) transporter
BT_0301	COG1131	(ABC) transporter
BT_0303	COG1752	Esterase of the alpha-beta hydrolase superfamily
BT_0311	COG0508	dehydrogenase complex catalyzes the overall conversion of
BT_0312	COG0022	dehydrogenase e1 component
BT_0314	COG2264	protein methyltransferase activity
BT_0317	COG4206	TonB-dependent receptor
BT_0317	COG1629	transport
BT_0321	COG0590	tRNA wobble adenosine to inosine editing
BT_0322	COG0673	inositol 2-dehydrogenase activity
BT_0327	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BT_0335	COG0714	Associated with various cellular activities
BT_0336	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BT_0339	COG1501	Belongs to the glycosyl hydrolase 31 family
BT_0340	COG5012	cobalamin binding
BT_0346	COG0698	ribose 5-phosphate isomerase
BT_0347	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BT_0350	COG1070	Carbohydrate kinase
BT_0351	COG2160	L-arabinose isomerase activity
BT_0361	COG0702	epimerase
BT_0362	COG4206	TonB-dependent receptor
BT_0362	COG1629	transport
BT_0363	COG0702	epimerase
BT_0364	COG4206	TonB-dependent receptor
BT_0364	COG1629	transport
BT_0366	COG0745	RESPONSE REGULATOR receiver
BT_0366	COG2205	protein histidine kinase activity
BT_0366	COG3292	Two component regulator propeller
BT_0367	COG3507	Belongs to the glycosyl hydrolase 43 family
BT_0369	COG3507	Belongs to the glycosyl hydrolase 43 family
BT_0370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BT_0373	COG1482	cell wall glycoprotein biosynthetic process
BT_0381	COG1086	Polysaccharide biosynthesis protein
BT_0409	COG4221	oxidoreductase activity
BT_0411	COG1218	3'(2'),5'-bisphosphate nucleotidase
BT_0412	COG3273	potassium ion transport
BT_0412	COG0471	metal ion transport
BT_0413	COG0529	Catalyzes the synthesis of activated sulfate
BT_0414	COG0175	sulfate reduction
BT_0415	COG2895	sulfate adenylyltransferase (ATP) activity
BT_0419	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BT_0420	COG0242	peptide deformylase activity
BT_0422	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BT_0423	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BT_0424	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BT_0425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BT_0427	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BT_0428	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BT_0429	COG0674	pyruvate-flavodoxin oxidoreductase activity
BT_0429	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BT_0429	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BT_0429	COG1013	pyruvate-flavodoxin oxidoreductase activity
BT_0431	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BT_0433	COG1940	carbohydrate kinase activity
BT_0434	COG2081	HI0933 family
BT_0436	COG2814	Major facilitator Superfamily
BT_0439	COG4771	TonB-dependent receptor
BT_0443	COG1472	Belongs to the glycosyl hydrolase 3 family
BT_0445	COG2755	lipolytic protein G-D-S-L family
BT_0445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BT_0452	COG4771	TonB-dependent receptor
BT_0454	COG2814	Major facilitator Superfamily
BT_0456	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_0457	COG2755	lipolytic protein G-D-S-L family
BT_0457	COG0657	acetylesterase activity
BT_0459	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_0460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_0461	COG3250	beta-galactosidase activity
BT_0465	COG1091	dTDP-4-dehydrorhamnose reductase activity
BT_0475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BT_0477	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BT_0483	COG4771	TonB-dependent receptor
BT_0484	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BT_0486	COG2721	sulfolactate sulfo-lyase activity
BT_0487	COG1609	Transcriptional regulator
BT_0494	COG1429	ligase activity, forming nitrogen-metal bonds
BT_0496	COG4771	TonB-dependent receptor
BT_0499	COG1230	cation diffusion facilitator family transporter
BT_0500	COG0490	domain, Protein
BT_0500	COG2985	domain, Protein
BT_0502	COG4771	TonB-dependent receptor
BT_0504	COG4771	TonB-dependent receptor
BT_0506	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_0509	COG1132	(ABC) transporter
BT_0517	COG0716	FMN binding
BT_0518	COG0138	bifunctional purine biosynthesis protein purh
BT_0520	COG2197	response regulator
BT_0521	COG0110	maltose O-acetyltransferase activity
BT_0523	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BT_0524	COG3292	Two component regulator propeller
BT_0524	COG2205	protein histidine kinase activity
BT_0524	COG0745	RESPONSE REGULATOR receiver
BT_0526	COG0252	asparaginase activity
BT_0527	COG0159	tryptophan synthase activity
BT_0528	COG0135	phosphoribosylanthranilate isomerase activity
BT_0529	COG0134	indole-3-glycerol-phosphate synthase activity
BT_0530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BT_0532	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BT_0533	COG0133	tryptophan synthase activity
BT_0535	COG1979	alcohol dehydrogenase
BT_0536	COG5002	protein histidine kinase activity
BT_0537	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BT_0537	COG2205	protein histidine kinase activity
BT_0539	COG0490	domain, Protein
BT_0539	COG0471	metal ion transport
BT_0541	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BT_0544	COG0004	ammonium transporteR
BT_0545	COG0347	Belongs to the P(II) protein family
BT_0547	COG0436	Aminotransferase
BT_0548	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BT_0551	COG0367	asparagine synthase
BT_0553	COG0069	glutamate synthase activity
BT_0553	COG0067	glutamate synthase
BT_0553	COG0070	glutamate synthase
BT_0554	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BT_0556	COG0505	Belongs to the CarA family
BT_0557	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BT_0559	COG2207	Transcriptional regulator
BT_0559	COG1917	Cupin 2, conserved barrel domain protein
BT_0562	COG1131	(ABC) transporter
BT_0563	COG0842	Transport permease protein
BT_0564	COG0842	Transport permease protein
BT_0566	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BT_0567	COG2949	membrane
BT_0570	COG0556	nucleotide-excision repair
BT_0571	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BT_0577	COG1388	LysM domain
BT_0577	COG3942	CHAP domain
BT_0579	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BT_0580	COG3104	oligopeptide transport
BT_0582	COG1695	Transcriptional regulator
BT_0583	COG1983	PspC domain protein
BT_0587	COG1506	peptidase
BT_0587	COG0823	Involved in the tonB-independent uptake of proteins
BT_0588	COG0534	Mate efflux family protein
BT_0589	COG0706	membrane insertase activity
BT_0590	COG0504	CTP synthase activity
BT_0601	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BT_0602	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BT_0608	COG0438	transferase activity, transferring glycosyl groups
BT_0611	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BT_0618	COG4656	Part of a membrane complex involved in electron transport
BT_0619	COG4658	electron transport chain
BT_0620	COG4659	FMN binding
BT_0621	COG4660	Part of a membrane complex involved in electron transport
BT_0622	COG4657	Part of a membrane complex involved in electron transport
BT_0623	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BT_0624	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BT_0625	COG0305	Participates in initiation and elongation during chromosome replication
BT_0626	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BT_0626	COG0072	phenylalanine-tRNA ligase activity
BT_0627	COG0217	transcriptional regulatory protein
BT_0630	COG0708	Exodeoxyribonuclease III
BT_0632	COG0481	GTPase activity
BT_0634	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BT_0638	COG0024	Methionine aminopeptidase
BT_0642	COG0564	pseudouridine synthase activity
BT_0643	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BT_0644	COG0574	Belongs to the PEP-utilizing enzyme family
BT_0644	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BT_0647	COG0352	thiamine-phosphate diphosphorylase activity
BT_0648	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BT_0649	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BT_0650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BT_0651	COG2022	thiamine diphosphate biosynthetic process
BT_0652	COG0352	thiamine-phosphate diphosphorylase activity
BT_0654	COG5002	protein histidine kinase activity
BT_0657	COG0210	DNA helicase
BT_0667	COG0681	Belongs to the peptidase S26 family
BT_0669	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_0673	COG2249	NAD(P)H dehydrogenase (quinone) activity
BT_0676	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BT_0677	COG3118	belongs to the thioredoxin family
BT_0681	COG2205	protein histidine kinase activity
BT_0682	COG0745	RESPONSE REGULATOR receiver
BT_0683	COG1082	Xylose isomerase domain protein TIM barrel
BT_0684	COG0318	PFAM AMP-dependent synthetase and ligase
BT_0685	COG3263	regulation of cellular component size
BT_0686	COG2233	PERMEase
BT_0687	COG1151	hydroxylamine reductase activity
BT_0694	COG1136	(ABC) transporter
BT_0696	COG0534	Mate efflux family protein
BT_0698	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BT_0700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BT_0704	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BT_0706	COG3023	N-Acetylmuramoyl-L-alanine amidase
BT_0711	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BT_0712	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BT_0714	COG0356	it plays a direct role in the translocation of protons across the membrane
BT_0715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BT_0716	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BT_0717	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BT_0718	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BT_0719	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BT_0721	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BT_0722	COG2431	L-lysine efflux transmembrane transporter activity
BT_0725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BT_0728	COG2207	Transcriptional regulator
BT_0736	COG2985	domain, Protein
BT_0737	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BT_0738	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BT_0741	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BT_0742	COG0540	Belongs to the ATCase OTCase family
BT_0745	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BT_0748	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BT_0749	COG2205	protein histidine kinase activity
BT_0754	COG4206	TonB-dependent receptor
BT_0754	COG1629	transport
BT_0756	COG3119	arylsulfatase activity
BT_0757	COG3250	beta-galactosidase activity
BT_0758	COG3153	acetyltransferase
BT_0760	COG0745	RESPONSE REGULATOR receiver
BT_0760	COG2205	protein histidine kinase activity
BT_0760	COG3292	Two component regulator propeller
BT_0765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BT_0767	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BT_0768	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BT_0771	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BT_0776	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
BT_0778	COG2326	polyphosphate kinase activity
BT_0787	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BT_0788	COG0045	succinate-CoA ligase (ADP-forming) activity
BT_0789	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BT_0790	COG0351	phosphomethylpyrimidine kinase
BT_0793	COG2115	Belongs to the xylose isomerase family
BT_0794	COG0477	Major facilitator Superfamily
BT_0794	COG2814	Major facilitator Superfamily
BT_0803	COG0798	PFAM Bile acid sodium symporter
BT_0804	COG3153	acetyltransferase
BT_0804	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BT_0806	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BT_0808	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BT_0811	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BT_0817	COG3015	lipoprotein NlpE involved in copper resistance
BT_0818	COG2198	Histidine kinase
BT_0818	COG0784	Response regulator, receiver
BT_0818	COG2205	protein histidine kinase activity
BT_0822	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BT_0823	COG1904	glucuronate isomerase
BT_0825	COG0246	Mannitol dehydrogenase
BT_0831	COG0513	Belongs to the DEAD box helicase family
BT_0832	COG0560	Phosphoserine phosphatase
BT_0832	COG3830	Belongs to the UPF0237 family
BT_0836	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BT_0837	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BT_0838	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BT_0853	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BT_0855	COG3852	Histidine kinase
BT_0860	COG1136	(ABC) transporter
BT_0867	COG4771	TonB-dependent receptor
BT_0870	COG0156	8-amino-7-oxononanoate synthase activity
BT_0871	COG1597	lipid kinase activity
BT_0872	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BT_0878	COG1132	(ABC) transporter
BT_0882	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BT_0888	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BT_0891	COG0543	2 iron, 2 sulfur cluster binding
BT_0892	COG0167	dihydroorotate dehydrogenase activity
BT_0893	COG0336	Belongs to the RNA methyltransferase TrmD family
BT_0894	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BT_0895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BT_0897	COG0326	Molecular chaperone. Has ATPase activity
BT_0907	COG2304	oxidoreductase activity
BT_0910	COG0714	Associated with various cellular activities
BT_0911	COG0776	regulation of translation
BT_0912	COG0776	regulation of translation
BT_0913	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BT_0914	COG0552	protein localization to endoplasmic reticulum
BT_0915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BT_0916	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BT_0920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BT_0927	COG2205	protein histidine kinase activity
BT_0928	COG0745	RESPONSE REGULATOR receiver
BT_0929	COG0442	prolyl-tRNA aminoacylation
BT_0947	COG0582	viral genome integration into host DNA
BT_0953	COG4974	Belongs to the 'phage' integrase family
BT_0955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_0958	COG2205	protein histidine kinase activity
BT_0958	COG3292	Two component regulator propeller
BT_0958	COG0745	RESPONSE REGULATOR receiver
BT_0960	COG4206	TonB-dependent receptor
BT_0966	COG1595	DNA-templated transcription, initiation
BT_0970	COG1011	Hydrolase
BT_0972	COG0300	oxidoreductase activity
BT_0975	COG2966	Psort location CytoplasmicMembrane, score
BT_0981	COG3292	Two component regulator propeller
BT_0981	COG0745	RESPONSE REGULATOR receiver
BT_0981	COG2205	protein histidine kinase activity
BT_0983	COG3250	beta-galactosidase activity
BT_0989	COG5002	protein histidine kinase activity
BT_0990	COG0745	RESPONSE REGULATOR receiver
BT_0992	COG3250	beta-galactosidase activity
BT_0996	COG3250	beta-galactosidase activity
BT_0998	COG5002	protein histidine kinase activity
BT_0998	COG0784	Response regulator, receiver
BT_0998	COG2205	protein histidine kinase activity
BT_1008	COG2755	lipolytic protein G-D-S-L family
BT_1008	COG0657	acetylesterase activity
BT_1009	COG0167	dihydroorotate dehydrogenase activity
BT_1011	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BT_1013	COG3408	Glycogen debranching enzyme
BT_1015	COG1028	Short-chain dehydrogenase reductase Sdr
BT_1019	COG3408	Glycogen debranching enzyme
BT_1024	COG0702	epimerase
BT_1025	COG4206	TonB-dependent receptor
BT_1025	COG1629	transport
BT_1028	COG0702	epimerase
BT_1029	COG1629	transport
BT_1032	COG3537	Alpha-1,2-mannosidase
BT_1033	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BT_1040	COG4771	TonB-dependent receptor
BT_1046	COG1629	transport
BT_1046	COG4206	TonB-dependent receptor
BT_1051	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_1055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BT_1069	COG1475	DNA binding
BT_1070	COG3969	phosphoadenosine phosphosulfate
BT_1075	COG3275	phosphorelay sensor kinase activity
BT_1078	COG1678	Uncharacterized ACR, COG1678
BT_1081	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BT_1083	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BT_1089	COG0321	lipoyl(octanoyl) transferase activity
BT_1091	COG2217	Heavy metal translocating P-type atpase
BT_1099	COG0010	Belongs to the arginase family
BT_1100	COG0058	SHG alpha-glucan phosphorylase activity
BT_1101	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BT_1101	COG4651	solute:proton antiporter activity
BT_1102	COG0205	6-phosphofructokinase activity
BT_1105	COG0588	phosphoglycerate mutase activity
BT_1106	COG1830	Aldolase
BT_1108	COG2095	MarC family integral membrane protein
BT_1115	COG0667	Aldo Keto reductase
BT_1118	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BT_1119	COG4771	TonB-dependent receptor
BT_1122	COG2706	6-phosphogluconolactonase activity
BT_1123	COG2207	Transcriptional regulator
BT_1138	COG4974	Belongs to the 'phage' integrase family
BT_1145	COG0357	Ribosomal RNA small subunit methyltransferase G
BT_1146	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BT_1147	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BT_1147	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BT_1148	COG0778	Nitroreductase
BT_1150	COG1739	Uncharacterized protein family UPF0029
BT_1153	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BT_1155	COG2871	sodium ion transport
BT_1156	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BT_1158	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BT_1159	COG1805	sodium ion transport
BT_1166	COG1215	transferase activity, transferring glycosyl groups
BT_1168	COG3023	N-Acetylmuramoyl-L-alanine amidase
BT_1176	COG1216	Glycosyl transferase, family 2
BT_1177	COG2244	polysaccharide biosynthetic process
BT_1179	COG1442	glycosyl transferase family 8
BT_1181	COG1215	transferase activity, transferring glycosyl groups
BT_1186	COG0488	(ABC) transporter
BT_1190	COG1162	GTPase activity
BT_1192	COG2755	lipolytic protein G-D-S-L family
BT_1192	COG0657	acetylesterase activity
BT_1193	COG0534	Mate efflux family protein
BT_1194	COG2885	chlorophyll binding
BT_1195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BT_1198	COG1704	LemA family
BT_1199	COG0501	Belongs to the peptidase M48B family
BT_1205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BT_1207	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BT_1213	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_1214	COG1136	(ABC) transporter
BT_1215	COG0577	efflux transmembrane transporter activity
BT_1215	COG1136	(ABC) transporter
BT_1217	COG3279	Response regulator of the LytR AlgR family
BT_1218	COG2135	peptidase activity
BT_1219	COG2837	iron assimilation
BT_1221	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BT_1222	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BT_1223	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BT_1224	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BT_1225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BT_1226	COG0318	PFAM AMP-dependent synthetase and ligase
BT_1228	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BT_1229	COG2985	domain, Protein
BT_1229	COG0490	domain, Protein
BT_1236	COG0737	Belongs to the 5'-nucleotidase family
BT_1237	COG2205	protein histidine kinase activity
BT_1237	COG2202	Pas domain
BT_1238	COG2183	response to ionizing radiation
BT_1242	COG0488	(ABC) transporter
BT_1243	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BT_1244	COG0484	heat shock protein binding
BT_1262	COG1733	regulation of RNA biosynthetic process
BT_1264	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BT_1264	COG0784	Response regulator, receiver
BT_1264	COG2198	Histidine kinase
BT_1264	COG2205	protein histidine kinase activity
BT_1266	COG3275	phosphorelay sensor kinase activity
BT_1271	COG0228	four-way junction DNA binding
BT_1272	COG2188	Transcriptional regulator
BT_1273	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
BT_1275	COG1070	Carbohydrate kinase
BT_1277	COG0738	Major facilitator superfamily
BT_1286	COG2207	Transcriptional regulator
BT_1289	COG1177	transmembrane transport
BT_1290	COG1176	ABC-type spermidine putrescine transport system, permease component I
BT_1291	COG3842	ATPase activity
BT_1292	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BT_1293	COG0058	SHG alpha-glucan phosphorylase activity
BT_1295	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BT_1299	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BT_1304	COG1725	Transcriptional regulator
BT_1306	COG1131	(ABC) transporter
BT_1311	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BT_1312	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BT_1313	COG4948	Mandelate Racemase Muconate Lactonizing
BT_1315	COG1295	ribonuclease BN
BT_1318	COG2972	Histidine kinase
BT_1320	COG0704	Plays a role in the regulation of phosphate uptake
BT_1321	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BT_1322	COG0581	inorganic phosphate transmembrane transporter activity
BT_1323	COG0573	inorganic phosphate transmembrane transporter activity
BT_1325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BT_1327	COG0586	Pfam SNARE associated Golgi protein
BT_1329	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BT_1332	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BT_1333	COG0167	dihydroorotate dehydrogenase activity
BT_1334	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BT_1339	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BT_1351	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BT_1353	COG1216	Glycosyl transferase, family 2
BT_1360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BT_1361	COG0497	DNA recombination
BT_1364	COG0592	DNA-directed DNA polymerase activity
BT_1367	COG0321	lipoyl(octanoyl) transferase activity
BT_1367	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BT_1368	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BT_1370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BT_1371	COG0156	8-amino-7-oxononanoate synthase activity
BT_1374	COG0019	diaminopimelate decarboxylase activity
BT_1375	COG0527	aspartate kinase activity
BT_1376	COG2884	Cell division ATP-binding protein ftsE
BT_1377	COG0140	phosphoribosyl-ATP diphosphatase activity
BT_1377	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BT_1378	COG0107	imidazoleglycerol-phosphate synthase activity
BT_1379	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BT_1380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BT_1381	COG0788	formyltetrahydrofolate deformylase activity
BT_1382	COG0693	protein deglycase activity
BT_1383	COG0656	L-ascorbic acid biosynthetic process
BT_1387	COG0534	Mate efflux family protein
BT_1388	COG2076	Multidrug Resistance protein
BT_1391	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BT_1391	COG2885	chlorophyll binding
BT_1398	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BT_1401	COG2814	Major facilitator Superfamily
BT_1406	COG1309	transcriptional regulator
BT_1407	COG1924	4 iron, 4 sulfur cluster binding
BT_1411	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BT_1412	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BT_1415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BT_1417	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BT_1420	COG4771	TonB-dependent receptor
BT_1432	COG1312	Catalyzes the dehydration of D-mannonate
BT_1433	COG1028	Short-chain dehydrogenase reductase Sdr
BT_1437	COG1929	Belongs to the glycerate kinase type-1 family
BT_1438	COG2223	nitrite transmembrane transporter activity
BT_1440	COG4771	TonB-dependent receptor
BT_1442	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BT_1442	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BT_1445	COG2226	methyltransferase
BT_1447	COG0784	Response regulator, receiver
BT_1447	COG5002	protein histidine kinase activity
BT_1448	COG0511	ligase activity, forming carbon-carbon bonds
BT_1449	COG0439	Biotin carboxylase
BT_1450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BT_1453	COG1620	l-lactate permease
BT_1454	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BT_1455	COG1690	Belongs to the RtcB family
BT_1463	COG0110	maltose O-acetyltransferase activity
BT_1465	COG0577	efflux transmembrane transporter activity
BT_1466	COG1136	(ABC) transporter
BT_1466	COG0577	efflux transmembrane transporter activity
BT_1471	COG0628	permease
BT_1472	COG1215	transferase activity, transferring glycosyl groups
BT_1474	COG0569	domain protein
BT_1474	COG0189	ligase activity
BT_1475	COG1136	(ABC) transporter
BT_1475	COG0577	efflux transmembrane transporter activity
BT_1476	COG0436	Aminotransferase
BT_1479	COG0488	(ABC) transporter
BT_1482	COG0745	RESPONSE REGULATOR receiver
BT_1483	COG5002	protein histidine kinase activity
BT_1492	COG3033	Beta-eliminating lyase
BT_1497	COG0629	single-stranded DNA binding
BT_1498	COG1194	a g-specific adenine glycosylase
BT_1500	COG1530	ribonuclease E activity
BT_1501	COG2885	chlorophyll binding
BT_1505	COG2885	chlorophyll binding
BT_1516	COG0305	Participates in initiation and elongation during chromosome replication
BT_1519	COG3023	N-Acetylmuramoyl-L-alanine amidase
BT_1523	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BT_1525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BT_1528	COG4191	Histidine kinase
BT_1529	COG2204	response regulator
BT_1531	COG0784	Response regulator, receiver
BT_1531	COG2205	protein histidine kinase activity
BT_1531	COG5002	protein histidine kinase activity
BT_1535	COG1136	(ABC) transporter
BT_1537	COG1252	NADH dehydrogenase
BT_1538	COG1705	Flagellar rod assembly protein muramidase FlgJ
BT_1541	COG3059	membrane
BT_1542	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BT_1543	COG0488	(ABC) transporter
BT_1548	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BT_1550	COG0739	heme binding
BT_1551	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BT_1552	COG1629	transport
BT_1552	COG4206	TonB-dependent receptor
BT_1554	COG0686	Belongs to the AlaDH PNT family
BT_1562	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BT_1564	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BT_1566	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BT_1572	COG1595	DNA-templated transcription, initiation
BT_1575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BT_1576	COG1741	Belongs to the pirin family
BT_1577	COG0259	pyridoxamine-phosphate oxidase activity
BT_1592	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BT_1592	COG1918	ferrous iron import across plasma membrane
BT_1593	COG0037	tRNA processing
BT_1596	COG3119	arylsulfatase activity
BT_1597	COG2202	Pas domain
BT_1597	COG2205	protein histidine kinase activity
BT_1598	COG2202	Pas domain
BT_1598	COG2205	protein histidine kinase activity
BT_1601	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BT_1605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BT_1606	COG1858	cytochrome C peroxidase
BT_1607	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BT_1609	COG1983	PspC domain protein
BT_1610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BT_1615	COG2195	Cleaves the N-terminal amino acid of tripeptides
BT_1619	COG1629	transport
BT_1619	COG4206	TonB-dependent receptor
BT_1622	COG3119	arylsulfatase activity
BT_1623	COG0668	transmembrane transport
BT_1624	COG3119	arylsulfatase activity
BT_1626	COG3250	beta-galactosidase activity
BT_1627	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_1628	COG3119	arylsulfatase activity
BT_1630	COG0702	epimerase
BT_1631	COG1629	transport
BT_1631	COG4206	TonB-dependent receptor
BT_1633	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BT_1634	COG1660	Displays ATPase and GTPase activities
BT_1635	COG0745	RESPONSE REGULATOR receiver
BT_1635	COG2205	protein histidine kinase activity
BT_1635	COG2205	protein histidine kinase activity
BT_1635	COG0745	RESPONSE REGULATOR receiver
BT_1635	COG3292	Two component regulator propeller
BT_1635	COG3292	Two component regulator propeller
BT_1636	COG3119	arylsulfatase activity
BT_1645	COG1216	Glycosyl transferase, family 2
BT_1646	COG1216	Glycosyl transferase, family 2
BT_1648	COG1442	glycosyl transferase family 8
BT_1648	COG1216	Glycosyl transferase, family 2
BT_1650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BT_1652	COG2244	polysaccharide biosynthetic process
BT_1658	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BT_1659	COG1830	Aldolase
BT_1660	COG0588	phosphoglycerate mutase activity
BT_1661	COG0784	Response regulator, receiver
BT_1661	COG2205	protein histidine kinase activity
BT_1662	COG1119	ATPase activity
BT_1663	COG1523	belongs to the glycosyl hydrolase 13 family
BT_1664	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BT_1666	COG0560	Phosphoserine phosphatase
BT_1669	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BT_1670	COG2814	Major facilitator Superfamily
BT_1671	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BT_1672	COG0126	phosphoglycerate kinase activity
BT_1676	COG0424	maF-like protein
BT_1680	COG0778	Nitroreductase
BT_1681	COG0288	reversible hydration of carbon dioxide
BT_1683	COG4771	TonB-dependent receptor
BT_1686	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BT_1688	COG0511	ligase activity, forming carbon-carbon bonds
BT_1689	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BT_1691	COG0191	fructose-bisphosphate aldolase activity
BT_1692	COG0254	rRNA binding
BT_1693	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_1694	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BT_1709	COG1216	Glycosyl transferase, family 2
BT_1713	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BT_1715	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BT_1716	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BT_1721	COG4750	Nucleotidyl transferase
BT_1729	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BT_1732	COG1280	lysine exporter protein (LysE YggA)
BT_1734	COG2205	protein histidine kinase activity
BT_1734	COG2205	protein histidine kinase activity
BT_1734	COG3292	Two component regulator propeller
BT_1734	COG3292	Two component regulator propeller
BT_1734	COG0745	RESPONSE REGULATOR receiver
BT_1734	COG0745	RESPONSE REGULATOR receiver
BT_1737	COG1649	PFAM Uncharacterised BCR, COG1649
BT_1742	COG1966	Carbon starvation protein
BT_1744	COG1649	PFAM Uncharacterised BCR, COG1649
BT_1749	COG2113	Glycine betaine
BT_1750	COG4176	ABC-type proline glycine betaine transport system permease component
BT_1754	COG3292	Two component regulator propeller
BT_1754	COG2205	protein histidine kinase activity
BT_1754	COG0745	RESPONSE REGULATOR receiver
BT_1757	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BT_1757	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BT_1759	COG1621	beta-fructofuranosidase activity
BT_1762	COG0561	phosphatase activity
BT_1763	COG4206	TonB-dependent receptor
BT_1763	COG1629	transport
BT_1765	COG1621	beta-fructofuranosidase activity
BT_1768	COG3250	beta-galactosidase activity
BT_1769	COG3537	Alpha-1,2-mannosidase
BT_1774	COG1629	transport
BT_1776	COG3250	beta-galactosidase activity
BT_1778	COG1472	Belongs to the glycosyl hydrolase 3 family
BT_1780	COG1472	Belongs to the glycosyl hydrolase 3 family
BT_1782	COG1752	Esterase of the alpha-beta hydrolase superfamily
BT_1783	COG0475	glutathione-regulated potassium exporter activity
BT_1791	COG2885	chlorophyll binding
BT_1794	COG3279	Response regulator of the LytR AlgR family
BT_1801	COG2205	protein histidine kinase activity
BT_1802	COG2205	protein histidine kinase activity
BT_1805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BT_1806	COG1960	acyl-CoA dehydrogenase activity
BT_1810	COG1956	GAF domain-containing protein
BT_1812	COG0484	heat shock protein binding
BT_1813	COG2194	sulfuric ester hydrolase activity
BT_1821	COG3385	transposase activity
BT_1822	COG0028	Belongs to the TPP enzyme family
BT_1829	COG0459	protein refolding
BT_1830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BT_1833	COG5002	protein histidine kinase activity
BT_1833	COG0784	Response regulator, receiver
BT_1833	COG2205	protein histidine kinase activity
BT_1835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BT_1837	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BT_1838	COG1506	peptidase
BT_1838	COG0823	Involved in the tonB-independent uptake of proteins
BT_1840	COG0124	histidyl-tRNA synthetase
BT_1843	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BT_1848	COG0514	ATP-dependent DNA helicase (RecQ)
BT_1852	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BT_1854	COG0671	phosphoesterase, PA-phosphatase related
BT_1857	COG0473	3-isopropylmalate dehydrogenase activity
BT_1859	COG0066	3-isopropylmalate dehydratase activity
BT_1860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BT_1861	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BT_1871	COG4948	Mandelate Racemase Muconate Lactonizing
BT_1873	COG3507	Belongs to the glycosyl hydrolase 43 family
BT_1874	COG0702	epimerase
BT_1875	COG4771	TonB-dependent receptor
BT_1879	COG0616	signal peptide processing
BT_1880	COG1663	tetraacyldisaccharide 4'-kinase activity
BT_1881	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BT_1882	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BT_1885	COG0513	Belongs to the DEAD box helicase family
BT_1886	COG2070	2-Nitropropane dioxygenase
BT_1887	COG0724	RNA recognition motif
BT_1890	COG3973	AAA domain
BT_1893	COG5433	transposase activity
BT_1897	COG1704	LemA family
BT_1900	COG0534	Mate efflux family protein
BT_1902	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BT_1904	COG1917	Cupin 2, conserved barrel domain protein
BT_1904	COG4977	sequence-specific DNA binding
BT_1911	COG1028	Short-chain dehydrogenase reductase Sdr
BT_1913	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BT_1915	COG0439	Biotin carboxylase
BT_1916	COG5016	pyruvate
BT_1916	COG0511	ligase activity, forming carbon-carbon bonds
BT_1917	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BT_1919	COG2855	membrane
BT_1923	COG2873	o-acetylhomoserine
BT_1928	COG4974	Belongs to the 'phage' integrase family
BT_1929	COG4974	Belongs to the 'phage' integrase family
BT_1933	COG3328	transposase activity
BT_1945	COG1192	Involved in chromosome partitioning
BT_1950	COG1120	ATPase activity
BT_1951	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BT_1965	COG1538	Outer membrane efflux protein
BT_1970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BT_1974	COG0024	Methionine aminopeptidase
BT_1975	COG0617	tRNA 3'-terminal CCA addition
BT_1978	COG0632	four-way junction helicase activity
BT_1979	COG0673	inositol 2-dehydrogenase activity
BT_1983	COG1272	protein, Hemolysin III
BT_1986	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BT_1991	COG3023	N-Acetylmuramoyl-L-alanine amidase
BT_1996	COG3328	transposase activity
BT_1998	COG1328	CTP reductase activity
BT_2000	COG2814	Major facilitator Superfamily
BT_2001	COG0750	zinc metalloprotease
BT_2002	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BT_2004	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BT_2005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BT_2009	COG0194	GDP metabolic process
BT_2011	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BT_2013	COG1408	metallophosphoesterase
BT_2014	COG1575	Belongs to the MenA family. Type 1 subfamily
BT_2016	COG1088	dTDP-glucose 4,6-dehydratase activity
BT_2017	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BT_2019	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BT_2023	COG2205	protein histidine kinase activity
BT_2027	COG3023	N-Acetylmuramoyl-L-alanine amidase
BT_2032	COG1629	transport
BT_2034	COG2205	protein histidine kinase activity
BT_2034	COG0784	Response regulator, receiver
BT_2035	COG0488	(ABC) transporter
BT_2044	COG1595	DNA-templated transcription, initiation
BT_2047	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BT_2049	COG1522	sequence-specific DNA binding
BT_2055	COG0811	peptide transport
BT_2056	COG0084	hydrolase, TatD family'
BT_2060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BT_2061	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BT_2062	COG0205	6-phosphofructokinase activity
BT_2070	COG0372	Belongs to the citrate synthase family
BT_2071	COG0538	isocitrate dehydrogenase activity
BT_2073	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BT_2074	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BT_2077	COG0028	Belongs to the TPP enzyme family
BT_2078	COG0129	dihydroxy-acid dehydratase activity
BT_2079	COG1047	Peptidyl-prolyl cis-trans
BT_2080	COG3681	Belongs to the UPF0597 family
BT_2084	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BT_2090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BT_2090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BT_2091	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BT_2092	COG0569	domain protein
BT_2092	COG2985	domain, Protein
BT_2099	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BT_2100	COG1120	ATPase activity
BT_2103	COG2188	Transcriptional regulator
BT_2107	COG4206	TonB-dependent receptor
BT_2107	COG1629	transport
BT_2119	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_2120	COG1609	Transcriptional regulator
BT_2120	COG2207	Transcriptional regulator
BT_2122	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BT_2123	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BT_2124	COG0166	Belongs to the GPI family
BT_2129	COG2502	aspartate--ammonia ligase
BT_2130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BT_2135	COG3876	Protein conserved in bacteria
BT_2141	COG0860	N-Acetylmuramoyl-L-alanine amidase
BT_2143	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BT_2144	COG0778	Nitroreductase
BT_2146	COG1640	4-alpha-glucanotransferase
BT_2149	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BT_2153	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BT_2154	COG0318	PFAM AMP-dependent synthetase and ligase
BT_2161	COG0359	binds to the 23S rRNA
BT_2162	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BT_2163	COG0360	Binds together with S18 to 16S ribosomal RNA
BT_2167	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BT_2168	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BT_2174	COG1131	(ABC) transporter
BT_2177	COG2431	L-lysine efflux transmembrane transporter activity
BT_2179	COG1193	negative regulation of DNA recombination
BT_2186	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BT_2189	COG2234	aminopeptidase activity
BT_2191	COG3250	beta-galactosidase activity
BT_2195	COG0702	epimerase
BT_2196	COG1629	transport
BT_2199	COG3537	Alpha-1,2-mannosidase
BT_2202	COG1629	transport
BT_2202	COG4206	TonB-dependent receptor
BT_2206	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BT_2207	COG0802	atpase or kinase
BT_2212	COG0714	Associated with various cellular activities
BT_2222	COG3385	transposase activity
BT_2229	COG3118	belongs to the thioredoxin family
BT_2231	COG0688	phosphatidylethanolamine metabolic process
BT_2232	COG1183	phosphatidylcholine synthase activity
BT_2236	COG0792	nuclease activity
BT_2241	COG0534	Mate efflux family protein
BT_2242	COG0528	UMP kinase activity
BT_2249	COG0233	cytoplasmic translational termination
BT_2250	COG1162	GTPase activity
BT_2252	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BT_2256	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BT_2256	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BT_2258	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BT_2260	COG4771	TonB-dependent receptor
BT_2264	COG1629	transport
BT_2267	COG4974	Belongs to the 'phage' integrase family
BT_2268	COG4771	TonB-dependent receptor
BT_2270	COG2095	MarC family integral membrane protein
BT_2273	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BT_2275	COG1435	thymidine kinase activity
BT_2276	COG0628	permease
BT_2277	COG4974	Belongs to the 'phage' integrase family
BT_2297	COG3344	reverse transcriptase
BT_2310	COG1475	DNA binding
BT_2311	COG3969	phosphoadenosine phosphosulfate
BT_2324	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BT_2324	COG0551	DNA topoisomerase type I activity
BT_2349	COG2433	Pfam Transposase IS66
BT_2352	COG2433	Pfam Transposase IS66
BT_2360	COG1396	sequence-specific DNA binding
BT_2362	COG4771	TonB-dependent receptor
BT_2364	COG4771	TonB-dependent receptor
BT_2371	COG0693	protein deglycase activity
BT_2380	COG0300	oxidoreductase activity
BT_2382	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BT_2383	COG1595	DNA-templated transcription, initiation
BT_2384	COG0110	maltose O-acetyltransferase activity
BT_2386	COG1522	sequence-specific DNA binding
BT_2391	COG0745	RESPONSE REGULATOR receiver
BT_2391	COG2205	protein histidine kinase activity
BT_2391	COG3292	Two component regulator propeller
BT_2393	COG1629	transport
BT_2400	COG2818	Glycosylase
BT_2401	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BT_2402	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BT_2403	COG0527	aspartate kinase activity
BT_2403	COG0460	homoserine dehydrogenase
BT_2404	COG0252	asparaginase activity
BT_2406	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BT_2407	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BT_2409	COG4771	TonB-dependent receptor
BT_2412	COG0826	peptidase U32
BT_2413	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BT_2415	COG0436	Aminotransferase
BT_2416	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BT_2419	COG0519	Catalyzes the synthesis of GMP from XMP
BT_2420	COG5002	protein histidine kinase activity
BT_2421	COG2205	protein histidine kinase activity
BT_2423	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BT_2425	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BT_2432	COG3250	beta-galactosidase activity
BT_2433	COG2204	response regulator
BT_2434	COG0446	pyridine nucleotide-disulphide oxidoreductase
BT_2439	COG1472	Belongs to the glycosyl hydrolase 3 family
BT_2440	COG0737	Belongs to the 5'-nucleotidase family
BT_2441	COG0737	Belongs to the 5'-nucleotidase family
BT_2446	COG4974	Belongs to the 'phage' integrase family
BT_2458	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BT_2459	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_2461	COG4771	TonB-dependent receptor
BT_2474	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BT_2474	COG1333	cytochrome c biogenesis protein
BT_2489	COG0335	large ribosomal subunit rRNA binding
BT_2493	COG1940	carbohydrate kinase activity
BT_2494	COG0577	efflux transmembrane transporter activity
BT_2494	COG1136	(ABC) transporter
BT_2495	COG1136	(ABC) transporter
BT_2495	COG0577	efflux transmembrane transporter activity
BT_2496	COG0577	efflux transmembrane transporter activity
BT_2496	COG1136	(ABC) transporter
BT_2497	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_2499	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BT_2499	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BT_2501	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BT_2505	COG2996	Protein conserved in bacteria
BT_2510	COG0039	L-malate dehydrogenase activity
BT_2512	COG2217	Heavy metal translocating P-type atpase
BT_2517	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BT_2518	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BT_2519	COG0509	glycine decarboxylation via glycine cleavage system
BT_2522	COG0006	proline dipeptidase activity
BT_2523	COG3250	beta-galactosidase activity
BT_2524	COG3408	Glycogen debranching enzyme
BT_2525	COG3458	cephalosporin-C deacetylase activity
BT_2528	COG1283	sodium-dependent phosphate transmembrane transporter activity
BT_2531	COG1629	transport
BT_2531	COG4206	TonB-dependent receptor
BT_2539	COG1773	rubredoxin
BT_2541	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BT_2542	COG1011	Hydrolase
BT_2543	COG0196	riboflavin kinase activity
BT_2544	COG1266	CAAX protease self-immunity
BT_2546	COG3655	Transcriptional regulator
BT_2547	COG2166	iron-sulfur cluster assembly
BT_2548	COG2234	aminopeptidase activity
BT_2549	COG1619	proteins homologs of microcin C7 resistance protein MccF
BT_2551	COG0280	phosphate acetyltransferase
BT_2552	COG3426	butyrate kinase activity
BT_2560	COG4206	TonB-dependent receptor
BT_2560	COG1629	transport
BT_2563	COG1185	polyribonucleotide nucleotidyltransferase activity
BT_2565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BT_2569	COG1595	DNA-templated transcription, initiation
BT_2570	COG0076	glutamate decarboxylase activity
BT_2571	COG2066	Belongs to the glutaminase family
BT_2573	COG0531	amino acid
BT_2606	COG4804	nuclease activity
BT_2615	COG3344	reverse transcriptase
BT_2617	COG3344	reverse transcriptase
BT_2619	COG2205	protein histidine kinase activity
BT_2619	COG2198	Histidine kinase
BT_2619	COG0784	Response regulator, receiver
BT_2619	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BT_2620	COG4948	Mandelate Racemase Muconate Lactonizing
BT_2621	COG2755	lipolytic protein G-D-S-L family
BT_2621	COG0657	acetylesterase activity
BT_2622	COG3661	Belongs to the glycosyl hydrolase 67 family
BT_2625	COG0702	epimerase
BT_2626	COG4771	TonB-dependent receptor
BT_2628	COG3292	Two component regulator propeller
BT_2628	COG2205	protein histidine kinase activity
BT_2628	COG0745	RESPONSE REGULATOR receiver
BT_2629	COG3537	Alpha-1,2-mannosidase
BT_2634	COG4974	Belongs to the 'phage' integrase family
BT_2635	COG0582	viral genome integration into host DNA
BT_2644	COG0551	DNA topoisomerase type I activity
BT_2644	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BT_2679	COG0667	Aldo Keto reductase
BT_2680	COG3250	beta-galactosidase activity
BT_2687	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_2689	COG1309	transcriptional regulator
BT_2690	COG2986	histidine ammonia-lyase
BT_2692	COG1228	amidohydrolase
BT_2694	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BT_2697	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BT_2700	COG0203	ribosomal protein L17
BT_2701	COG0202	RNA polymerase activity
BT_2702	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BT_2703	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BT_2704	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BT_2705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BT_2708	COG0200	Binds to the 23S rRNA
BT_2709	COG1841	ribosomal large subunit assembly
BT_2710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BT_2711	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BT_2712	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BT_2713	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BT_2714	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BT_2715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BT_2716	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BT_2717	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BT_2718	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BT_2719	COG0255	Belongs to the universal ribosomal protein uL29 family
BT_2720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BT_2721	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BT_2722	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BT_2723	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BT_2724	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BT_2725	COG0089	rRNA binding
BT_2726	COG0088	Forms part of the polypeptide exit tunnel
BT_2727	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BT_2728	COG0051	transcription antitermination factor activity, RNA binding
BT_2729	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BT_2730	COG0049	tRNA binding
BT_2731	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BT_2733	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BT_2734	COG0085	RNA polymerase activity
BT_2735	COG0222	ribosome binding
BT_2736	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BT_2737	COG0081	regulation of translation
BT_2738	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BT_2740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BT_2742	COG4974	Belongs to the 'phage' integrase family
BT_2743	COG0006	proline dipeptidase activity
BT_2744	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BT_2748	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BT_2750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BT_2752	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BT_2755	COG1027	Aspartate ammonia-lyase
BT_2756	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BT_2757	COG0252	asparaginase activity
BT_2760	COG2096	Adenosyltransferase
BT_2763	COG3328	transposase activity
BT_2769	COG0515	serine threonine protein kinase
BT_2769	COG2815	serine threonine protein kinase
BT_2772	COG0631	protein serine/threonine phosphatase activity
BT_2774	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BT_2781	COG0662	Cupin 2, conserved barrel domain protein
BT_2781	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BT_2782	COG0318	PFAM AMP-dependent synthetase and ligase
BT_2783	COG1396	sequence-specific DNA binding
BT_2786	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BT_2787	COG1217	gtp-binding protein TYPA
BT_2789	COG2059	Chromate
BT_2790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BT_2791	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BT_2797	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BT_2799	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BT_2801	COG0483	inositol monophosphate 1-phosphatase activity
BT_2803	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BT_2804	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BT_2805	COG1629	transport
BT_2805	COG4206	TonB-dependent receptor
BT_2811	COG3634	alkyl hydroperoxide reductase activity
BT_2813	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BT_2814	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BT_2815	COG2816	NAD+ diphosphatase activity
BT_2818	COG1629	transport
BT_2818	COG4206	TonB-dependent receptor
BT_2826	COG2205	protein histidine kinase activity
BT_2826	COG0745	RESPONSE REGULATOR receiver
BT_2826	COG3292	Two component regulator propeller
BT_2826	COG3292	Two component regulator propeller
BT_2826	COG2205	protein histidine kinase activity
BT_2826	COG0745	RESPONSE REGULATOR receiver
BT_2829	COG0018	arginyl-trna synthetase
BT_2831	COG0705	Rhomboid family
BT_2834	COG0339	signal peptide processing
BT_2835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BT_2836	COG0674	pyruvate-flavodoxin oxidoreductase activity
BT_2836	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BT_2837	COG1013	pyruvate-flavodoxin oxidoreductase activity
BT_2838	COG4591	ABC-type transport system involved in lipoprotein release permease component
BT_2839	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BT_2843	COG4974	Belongs to the 'phage' integrase family
BT_2846	COG0606	chelatase, subunit chli
BT_2850	COG2205	protein histidine kinase activity
BT_2854	COG1472	Belongs to the glycosyl hydrolase 3 family
BT_2855	COG3250	beta-galactosidase activity
BT_2858	COG0561	phosphatase activity
BT_2859	COG4206	TonB-dependent receptor
BT_2859	COG1629	transport
BT_2860	COG2205	protein histidine kinase activity
BT_2860	COG3292	Two component regulator propeller
BT_2860	COG0745	RESPONSE REGULATOR receiver
BT_2860	COG2205	protein histidine kinase activity
BT_2860	COG3292	Two component regulator propeller
BT_2860	COG0745	RESPONSE REGULATOR receiver
BT_2864	COG0438	transferase activity, transferring glycosyl groups
BT_2865	COG0438	transferase activity, transferring glycosyl groups
BT_2868	COG1215	transferase activity, transferring glycosyl groups
BT_2869	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BT_2873	COG1442	glycosyl transferase family 8
BT_2876	COG1216	Glycosyl transferase, family 2
BT_2876	COG1442	glycosyl transferase family 8
BT_2883	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BT_2887	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BT_2888	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BT_2894	COG4771	TonB-dependent receptor
BT_2897	COG2205	protein histidine kinase activity
BT_2897	COG3292	Two component regulator propeller
BT_2897	COG0745	RESPONSE REGULATOR receiver
BT_2905	COG1629	transport
BT_2912	COG3940	Belongs to the glycosyl hydrolase 43 family
BT_2913	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BT_2914	COG3119	arylsulfatase activity
BT_2919	COG0702	epimerase
BT_2920	COG4206	TonB-dependent receptor
BT_2920	COG1629	transport
BT_2922	COG3250	beta-galactosidase activity
BT_2923	COG2205	protein histidine kinase activity
BT_2923	COG3292	Two component regulator propeller
BT_2923	COG0745	RESPONSE REGULATOR receiver
BT_2933	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BT_2933	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BT_2936	COG0438	transferase activity, transferring glycosyl groups
BT_2938	COG0438	transferase activity, transferring glycosyl groups
BT_2945	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BT_2946	COG0438	transferase activity, transferring glycosyl groups
BT_2947	COG1216	Glycosyl transferase, family 2
BT_2948	COG5183	chlorophyll binding
BT_2948	COG2133	pyrroloquinoline quinone binding
BT_2952	COG1629	transport
BT_2952	COG4206	TonB-dependent receptor
BT_2955	COG1882	Formate acetyltransferase
BT_2956	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BT_2964	COG5492	domain, Protein
BT_2967	COG0702	epimerase
BT_2968	COG4771	TonB-dependent receptor
BT_2969	COG3250	beta-galactosidase activity
BT_2971	COG2205	protein histidine kinase activity
BT_2971	COG0745	RESPONSE REGULATOR receiver
BT_2971	COG3292	Two component regulator propeller
BT_2971	COG2205	protein histidine kinase activity
BT_2971	COG0745	RESPONSE REGULATOR receiver
BT_2971	COG3292	Two component regulator propeller
BT_2975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BT_2976	COG0545	Peptidyl-prolyl cis-trans isomerase
BT_2977	COG0545	Peptidyl-prolyl cis-trans isomerase
BT_2985	COG2003	Belongs to the UPF0758 family
BT_2999	COG0210	DNA helicase
BT_3009	COG1472	Belongs to the glycosyl hydrolase 3 family
BT_3012	COG1629	transport
BT_3013	COG0561	phosphatase activity
BT_3024	COG4771	TonB-dependent receptor
BT_3028	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BT_3029	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BT_3034	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BT_3035	COG3409	Peptidoglycan-binding domain 1 protein
BT_3035	COG0793	Belongs to the peptidase S41A family
BT_3046	COG1629	transport
BT_3049	COG2205	protein histidine kinase activity
BT_3049	COG3292	Two component regulator propeller
BT_3049	COG0745	RESPONSE REGULATOR receiver
BT_3051	COG3119	arylsulfatase activity
BT_3054	COG1053	succinate dehydrogenase
BT_3055	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BT_3057	COG3119	arylsulfatase activity
BT_3065	COG3345	alpha-galactosidase
BT_3070	COG0758	DNA mediated transformation
BT_3070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BT_3072	COG0826	peptidase U32
BT_3073	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BT_3077	COG0557	exoribonuclease II activity
BT_3080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BT_3081	COG1917	Cupin 2, conserved barrel domain protein
BT_3082	COG1621	beta-fructofuranosidase activity
BT_3085	COG1501	Belongs to the glycosyl hydrolase 31 family
BT_3089	COG0702	epimerase
BT_3090	COG4771	TonB-dependent receptor
BT_3095	COG3408	Glycogen debranching enzyme
BT_3095	COG3119	arylsulfatase activity
BT_3097	COG3292	Two component regulator propeller
BT_3097	COG0745	RESPONSE REGULATOR receiver
BT_3097	COG2205	protein histidine kinase activity
BT_3101	COG3119	arylsulfatase activity
BT_3103	COG4771	TonB-dependent receptor
BT_3109	COG3119	arylsulfatase activity
BT_3112	COG1073	alpha beta
BT_3113	COG2814	Major facilitator Superfamily
BT_3115	COG1012	belongs to the aldehyde dehydrogenase family
BT_3116	COG0012	GTP binding
BT_3117	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BT_3118	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BT_3121	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BT_3122	COG0662	Cupin 2, conserved barrel domain protein
BT_3122	COG2207	Transcriptional regulator
BT_3123	COG0697	spore germination
BT_3126	COG0495	leucyl-tRNA aminoacylation
BT_3127	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BT_3128	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BT_3129	COG1360	Flagellar Motor Protein
BT_3130	COG3537	Alpha-1,2-mannosidase
BT_3134	COG3292	Two component regulator propeller
BT_3134	COG2205	protein histidine kinase activity
BT_3134	COG0745	RESPONSE REGULATOR receiver
BT_3136	COG4974	Belongs to the 'phage' integrase family
BT_3156	COG1629	transport
BT_3160	COG5434	Belongs to the glycosyl hydrolase 28 family
BT_3162	COG0584	glycerophosphoryl diester phosphodiesterase
BT_3163	COG4948	Mandelate Racemase Muconate Lactonizing
BT_3164	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BT_3168	COG0731	radical SAM domain protein
BT_3168	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BT_3172	COG0745	RESPONSE REGULATOR receiver
BT_3172	COG3292	Two component regulator propeller
BT_3172	COG2205	protein histidine kinase activity
BT_3172	COG2205	protein histidine kinase activity
BT_3172	COG3292	Two component regulator propeller
BT_3172	COG0745	RESPONSE REGULATOR receiver
BT_3174	COG1629	transport
BT_3174	COG4206	TonB-dependent receptor
BT_3177	COG3119	arylsulfatase activity
BT_3178	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_3179	COG3250	beta-galactosidase activity
BT_3181	COG0659	secondary active sulfate transmembrane transporter activity
BT_3182	COG1592	Rubrerythrin
BT_3187	COG2027	D-alanyl-D-alanine carboxypeptidase
BT_3193	COG0427	acetyl-CoA hydrolase
BT_3195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BT_3200	COG3023	N-Acetylmuramoyl-L-alanine amidase
BT_3210	COG2177	Part of the ABC transporter FtsEX involved in
BT_3212	COG1968	undecaprenyl-diphosphatase activity
BT_3213	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BT_3214	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BT_3216	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BT_3219	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BT_3224	COG1611	Belongs to the LOG family
BT_3227	COG0594	ribonuclease P activity
BT_3228	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BT_3230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BT_3231	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BT_3232	COG1028	Short-chain dehydrogenase reductase Sdr
BT_3245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BT_3248	COG1121	(ABC) transporter
BT_3250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BT_3250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BT_3254	COG0823	Involved in the tonB-independent uptake of proteins
BT_3254	COG1506	peptidase
BT_3255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BT_3255	COG0116	Belongs to the methyltransferase superfamily
BT_3256	COG1045	serine acetyltransferase
BT_3257	COG3275	phosphorelay sensor kinase activity
BT_3258	COG3279	Response regulator of the LytR AlgR family
BT_3260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BT_3260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BT_3261	COG0142	geranyltranstransferase activity
BT_3264	COG1694	Mazg nucleotide pyrophosphohydrolase
BT_3265	COG1490	D-aminoacyl-tRNA deacylase activity
BT_3266	COG0322	excinuclease ABC activity
BT_3267	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BT_3268	COG0445	tRNA wobble uridine modification
BT_3271	COG4771	TonB-dependent receptor
BT_3277	COG2197	response regulator
BT_3279	COG1629	transport
BT_3279	COG4206	TonB-dependent receptor
BT_3283	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BT_3284	COG0700	Nucleoside recognition
BT_3285	COG2255	four-way junction helicase activity
BT_3289	COG3591	Belongs to the peptidase S1B family
BT_3292	COG3250	beta-galactosidase activity
BT_3293	COG3250	beta-galactosidase activity
BT_3294	COG4948	Mandelate Racemase Muconate Lactonizing
BT_3296	COG0702	epimerase
BT_3297	COG4771	TonB-dependent receptor
BT_3302	COG2205	protein histidine kinase activity
BT_3302	COG0745	RESPONSE REGULATOR receiver
BT_3302	COG3292	Two component regulator propeller
BT_3303	COG0513	Belongs to the DEAD box helicase family
BT_3308	COG0612	Peptidase, M16
BT_3310	COG4771	TonB-dependent receptor
BT_3311	COG0702	epimerase
BT_3314	COG1472	Belongs to the glycosyl hydrolase 3 family
BT_3318	COG0681	Belongs to the peptidase S26 family
BT_3320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BT_3322	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BT_3324	COG5492	domain, Protein
BT_3326	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BT_3331	COG0702	epimerase
BT_3332	COG4771	TonB-dependent receptor
BT_3333	COG3119	arylsulfatase activity
BT_3334	COG3292	Two component regulator propeller
BT_3334	COG2205	protein histidine kinase activity
BT_3334	COG2205	protein histidine kinase activity
BT_3334	COG0745	RESPONSE REGULATOR receiver
BT_3334	COG0745	RESPONSE REGULATOR receiver
BT_3334	COG3292	Two component regulator propeller
BT_3336	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BT_3337	COG1538	Outer membrane efflux protein
BT_3339	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_3340	COG3250	beta-galactosidase activity
BT_3345	COG0702	epimerase
BT_3346	COG4771	TonB-dependent receptor
BT_3348	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BT_3349	COG3119	arylsulfatase activity
BT_3350	COG5492	domain, Protein
BT_3351	COG0215	cysteine-tRNA ligase activity
BT_3352	COG0561	phosphatase activity
BT_3353	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BT_3354	COG0482	sulfurtransferase activity
BT_3356	COG0205	6-phosphofructokinase activity
BT_3357	COG0571	ribonuclease III activity
BT_3358	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BT_3359	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BT_3361	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BT_3366	COG1216	Glycosyl transferase, family 2
BT_3366	COG1442	glycosyl transferase family 8
BT_3370	COG1442	glycosyl transferase family 8
BT_3370	COG1216	Glycosyl transferase, family 2
BT_3371	COG1216	Glycosyl transferase, family 2
BT_3374	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BT_3375	COG0436	Aminotransferase
BT_3379	COG0463	Glycosyl transferase, family 2
BT_3386	COG1132	(ABC) transporter
BT_3391	COG3341	Caulimovirus viroplasmin
BT_3391	COG0328	RNA-DNA hybrid ribonuclease activity
BT_3393	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BT_3394	COG1166	arginine decarboxylase activity
BT_3395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BT_3396	COG1595	DNA-templated transcription, initiation
BT_3402	COG0779	Required for maturation of 30S ribosomal subunits
BT_3403	COG0195	Participates in both transcription termination and antitermination
BT_3404	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BT_3406	COG0719	Fe-S assembly protein
BT_3407	COG0396	ATPase activity
BT_3408	COG0719	Fe-S assembly protein
BT_3409	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BT_3410	COG0393	Putative heavy-metal-binding
BT_3411	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BT_3412	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BT_3416	COG5433	transposase activity
BT_3419	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BT_3429	COG0187	DNA topoisomerase II activity
BT_3430	COG0268	Binds directly to 16S ribosomal RNA
BT_3431	COG1381	Involved in DNA repair and RecF pathway recombination
BT_3443	COG1610	YqeY-like protein
BT_3444	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BT_3447	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BT_3448	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BT_3449	COG0772	Belongs to the SEDS family
BT_3450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BT_3451	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BT_3452	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BT_3455	COG0275	rRNA processing
BT_3456	COG2001	Belongs to the MraZ family
BT_3457	COG1595	DNA-templated transcription, initiation
BT_3460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BT_3461	COG0756	dUTP diphosphatase activity
BT_3464	COG4942	peptidase
BT_3465	COG2205	protein histidine kinase activity
BT_3465	COG3292	Two component regulator propeller
BT_3465	COG0745	RESPONSE REGULATOR receiver
BT_3470	COG0673	inositol 2-dehydrogenase activity
BT_3472	COG0673	inositol 2-dehydrogenase activity
BT_3474	COG0702	epimerase
BT_3475	COG4771	TonB-dependent receptor
BT_3483	COG1629	transport
BT_3486	COG3119	arylsulfatase activity
BT_3493	COG4206	TonB-dependent receptor
BT_3493	COG1629	transport
BT_3494	COG4771	TonB-dependent receptor
BT_3495	COG0702	epimerase
BT_3505	COG4771	TonB-dependent receptor
BT_3506	COG0702	epimerase
BT_3513	COG3250	beta-galactosidase activity
BT_3516	COG3507	Belongs to the glycosyl hydrolase 43 family
BT_3519	COG1629	transport
BT_3520	COG0561	phosphatase activity
BT_3527	COG3537	Alpha-1,2-mannosidase
BT_3530	COG3537	Alpha-1,2-mannosidase
BT_3532	COG2017	converts alpha-aldose to the beta-anomer
BT_3548	COG1373	ATPase (AAA superfamily
BT_3549	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BT_3550	COG1022	Amp-dependent synthetase and ligase
BT_3551	COG0612	Peptidase, M16
BT_3552	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BT_3554	COG2954	triphosphatase activity
BT_3567	COG1472	Belongs to the glycosyl hydrolase 3 family
BT_3569	COG4771	TonB-dependent receptor
BT_3581	COG0673	inositol 2-dehydrogenase activity
BT_3583	COG0673	inositol 2-dehydrogenase activity
BT_3587	COG0363	glucosamine-6-phosphate deaminase activity
BT_3588	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BT_3592	COG3345	alpha-galactosidase
BT_3598	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_3601	COG0517	IMP dehydrogenase activity
BT_3601	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BT_3604	COG4771	TonB-dependent receptor
BT_3606	COG2814	Major facilitator Superfamily
BT_3608	COG3458	cephalosporin-C deacetylase activity
BT_3609	COG1609	Transcriptional regulator
BT_3609	COG2207	Transcriptional regulator
BT_3611	COG0423	glycine-tRNA ligase activity
BT_3613	COG1609	Transcriptional regulator
BT_3616	COG0738	Major facilitator superfamily
BT_3617	COG1063	alcohol dehydrogenase
BT_3620	COG2211	Major facilitator Superfamily
BT_3621	COG2247	cell wall binding repeat
BT_3621	COG2385	sporulation resulting in formation of a cellular spore
BT_3622	COG1215	transferase activity, transferring glycosyl groups
BT_3623	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BT_3636	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BT_3638	COG0589	response to stress
BT_3638	COG0475	glutathione-regulated potassium exporter activity
BT_3639	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BT_3640	COG1136	(ABC) transporter
BT_3642	COG0733	neurotransmitter:sodium symporter activity
BT_3644	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BT_3645	COG0784	Response regulator, receiver
BT_3645	COG5002	protein histidine kinase activity
BT_3646	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BT_3647	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BT_3648	COG0312	modulator of DNA gyrase
BT_3649	COG0312	modulator of DNA gyrase
BT_3650	COG1704	LemA family
BT_3656	COG3507	Belongs to the glycosyl hydrolase 43 family
BT_3659	COG1501	Belongs to the glycosyl hydrolase 31 family
BT_3661	COG4948	Mandelate Racemase Muconate Lactonizing
BT_3664	COG1082	Xylose isomerase domain protein TIM barrel
BT_3670	COG1629	transport
BT_3670	COG4206	TonB-dependent receptor
BT_3678	COG2205	protein histidine kinase activity
BT_3678	COG0745	RESPONSE REGULATOR receiver
BT_3678	COG3292	Two component regulator propeller
BT_3680	COG1629	transport
BT_3690	COG1346	cytolysis
BT_3691	COG1380	Effector of murein hydrolase LrgA
BT_3692	COG0280	phosphate acetyltransferase
BT_3693	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BT_3694	COG0463	Glycosyl transferase, family 2
BT_3694	COG1216	Glycosyl transferase, family 2
BT_3695	COG2003	Belongs to the UPF0758 family
BT_3697	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BT_3698	COG0366	Alpha amylase catalytic
BT_3701	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BT_3702	COG1629	transport
BT_3702	COG4206	TonB-dependent receptor
BT_3703	COG1082	Xylose isomerase domain protein TIM barrel
BT_3704	COG0366	Alpha amylase catalytic
BT_3708	COG1785	Belongs to the alkaline phosphatase family
BT_3709	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BT_3710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BT_3711	COG0515	serine threonine protein kinase
BT_3711	COG2815	serine threonine protein kinase
BT_3712	COG0564	pseudouridine synthase activity
BT_3713	COG1181	Belongs to the D-alanine--D-alanine ligase family
BT_3717	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BT_3718	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BT_3719	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BT_3720	COG0436	Aminotransferase
BT_3722	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BT_3725	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BT_3726	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BT_3728	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BT_3728	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BT_3729	COG2890	protein-(glutamine-N5) methyltransferase activity
BT_3731	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BT_3733	COG0165	Argininosuccinate lyase
BT_3734	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BT_3738	COG3292	Two component regulator propeller
BT_3738	COG0745	RESPONSE REGULATOR receiver
BT_3738	COG0745	RESPONSE REGULATOR receiver
BT_3738	COG2205	protein histidine kinase activity
BT_3738	COG3292	Two component regulator propeller
BT_3738	COG2205	protein histidine kinase activity
BT_3739	COG0471	metal ion transport
BT_3750	COG4771	TonB-dependent receptor
BT_3755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BT_3756	COG1396	sequence-specific DNA binding
BT_3756	COG1917	Cupin 2, conserved barrel domain protein
BT_3757	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BT_3758	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BT_3759	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BT_3760	COG0137	argininosuccinate synthase activity
BT_3762	COG1438	arginine binding
BT_3763	COG1070	Carbohydrate kinase
BT_3764	COG4806	L-rhamnose isomerase
BT_3766	COG0235	Class ii aldolase
BT_3767	COG1454	alcohol dehydrogenase
BT_3772	COG0564	pseudouridine synthase activity
BT_3784	COG3537	Alpha-1,2-mannosidase
BT_3786	COG3292	Two component regulator propeller
BT_3786	COG0745	RESPONSE REGULATOR receiver
BT_3786	COG2205	protein histidine kinase activity
BT_3788	COG4206	TonB-dependent receptor
BT_3788	COG1629	transport
BT_3789	COG0702	epimerase
BT_3796	COG3119	arylsulfatase activity
BT_3799	COG3119	arylsulfatase activity
BT_3800	COG2205	protein histidine kinase activity
BT_3800	COG0745	RESPONSE REGULATOR receiver
BT_3800	COG3292	Two component regulator propeller
BT_3801	COG2204	response regulator
BT_3802	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BT_3803	COG0612	Peptidase, M16
BT_3804	COG0534	Mate efflux family protein
BT_3805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BT_3805	COG2205	protein histidine kinase activity
BT_3809	COG0488	(ABC) transporter
BT_3811	COG3590	peptidase
BT_3812	COG0138	bifunctional purine biosynthesis protein purh
BT_3817	COG0772	Belongs to the SEDS family
BT_3819	COG1774	PSP1 C-terminal conserved region
BT_3820	COG0470	DNA polymerase III
BT_3821	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BT_3823	COG2193	ferroxidase activity
BT_3834	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BT_3835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BT_3836	COG1160	GTP binding
BT_3838	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BT_3839	COG1127	ABC transporter
BT_3840	COG0724	RNA recognition motif
BT_3841	COG0544	peptidyl-prolyl cis-trans isomerase activity
BT_3842	COG0740	serine-type endopeptidase activity
BT_3843	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BT_3844	COG0514	ATP-dependent DNA helicase (RecQ)
BT_3845	COG0517	IMP dehydrogenase activity
BT_3845	COG0516	GMP reductase activity
BT_3846	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BT_3848	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BT_3851	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BT_3854	COG4771	TonB-dependent receptor
BT_3858	COG3537	Alpha-1,2-mannosidase
BT_3866	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BT_3869	COG3022	response to hydroperoxide
BT_3870	COG0110	maltose O-acetyltransferase activity
BT_3872	COG1187	pseudouridine synthase activity
BT_3873	COG0017	Asparaginyl-tRNA synthetase
BT_3875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BT_3876	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BT_3877	COG0052	Belongs to the universal ribosomal protein uS2 family
BT_3878	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BT_3882	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BT_3883	COG0179	Fumarylacetoacetate (FAA) hydrolase
BT_3884	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BT_3888	COG0482	sulfurtransferase activity
BT_3890	COG1570	exodeoxyribonuclease VII activity
BT_3892	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BT_3894	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BT_3895	COG0489	protein tyrosine kinase activity
BT_3897	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BT_3904	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_3908	COG0714	Associated with various cellular activities
BT_3909	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BT_3910	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BT_3911	COG0039	L-malate dehydrogenase activity
BT_3917	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BT_3918	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BT_3919	COG0811	peptide transport
BT_3923	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BT_3924	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BT_3925	COG0105	UTP biosynthetic process
BT_3926	COG0739	heme binding
BT_3929	COG0149	triose-phosphate isomerase activity
BT_3931	COG0302	gtp cyclohydrolase
BT_3932	COG0358	DNA primase activity
BT_3934	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BT_3935	COG0436	Aminotransferase
BT_3938	COG0514	ATP-dependent DNA helicase (RecQ)
BT_3939	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BT_3939	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BT_3943	COG0009	L-threonylcarbamoyladenylate synthase
BT_3945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BT_3946	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BT_3947	COG2333	competence protein COMEC
BT_3947	COG0658	competence protein
BT_3948	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BT_3950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BT_3952	COG4771	TonB-dependent receptor
BT_3953	COG0561	phosphatase activity
BT_3957	COG0745	RESPONSE REGULATOR receiver
BT_3957	COG2205	protein histidine kinase activity
BT_3957	COG3292	Two component regulator propeller
BT_3958	COG4771	TonB-dependent receptor
BT_3962	COG3537	Alpha-1,2-mannosidase
BT_3963	COG3537	Alpha-1,2-mannosidase
BT_3965	COG3537	Alpha-1,2-mannosidase
BT_3966	COG3279	Response regulator of the LytR AlgR family
BT_3967	COG3275	phosphorelay sensor kinase activity
BT_3968	COG1566	PFAM secretion protein HlyD family protein
BT_3971	COG0386	Belongs to the glutathione peroxidase family
BT_3972	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BT_3973	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BT_3975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BT_3978	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BT_3979	COG0742	ribosomal rna small subunit methyltransferase
BT_3982	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BT_3983	COG4771	TonB-dependent receptor
BT_3990	COG3537	Alpha-1,2-mannosidase
BT_3991	COG3537	Alpha-1,2-mannosidase
BT_3995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BT_3996	COG0739	heme binding
BT_3998	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BT_3999	COG1388	LysM domain
BT_3999	COG0741	lytic transglycosylase activity
BT_4001	COG1475	DNA binding
BT_4002	COG1192	Involved in chromosome partitioning
BT_4003	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BT_4004	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BT_4006	COG4589	Belongs to the CDS family
BT_4007	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BT_4008	COG0799	negative regulation of ribosome biogenesis
BT_4021	COG4974	Belongs to the 'phage' integrase family
BT_4022	COG4974	Belongs to the 'phage' integrase family
BT_4023	COG4974	Belongs to the 'phage' integrase family
BT_4031	COG3023	N-Acetylmuramoyl-L-alanine amidase
BT_4038	COG0702	epimerase
BT_4039	COG1629	transport
BT_4039	COG4206	TonB-dependent receptor
BT_4040	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_4040	COG3291	Pkd domain containing protein
BT_4041	COG1196	nuclear chromosome segregation
BT_4042	COG2239	Acts as a magnesium transporter
BT_4043	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BT_4045	COG2195	Cleaves the N-terminal amino acid of tripeptides
BT_4052	COG1119	ATPase activity
BT_4053	COG0668	transmembrane transport
BT_4054	COG0662	Cupin 2, conserved barrel domain protein
BT_4054	COG2207	Transcriptional regulator
BT_4059	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BT_4060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BT_4061	COG0713	ATP synthesis coupled electron transport
BT_4064	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BT_4065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BT_4065	COG0649	NAD binding
BT_4066	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BT_4067	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BT_4074	COG3250	beta-galactosidase activity
BT_4076	COG3250	beta-galactosidase activity
BT_4078	COG2755	lipolytic protein G-D-S-L family
BT_4078	COG0657	acetylesterase activity
BT_4081	COG1629	transport
BT_4082	COG0702	epimerase
BT_4085	COG0702	epimerase
BT_4088	COG4771	TonB-dependent receptor
BT_4089	COG0702	epimerase
BT_4090	COG4206	TonB-dependent receptor
BT_4090	COG1629	transport
BT_4093	COG3537	Alpha-1,2-mannosidase
BT_4097	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BT_4098	COG0569	domain protein
BT_4099	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BT_4101	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BT_4102	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BT_4103	COG0805	protein transport
BT_4105	COG2271	Major facilitator Superfamily
BT_4106	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BT_4107	COG3775	system Galactitol-specific IIC component
BT_4110	COG2755	lipolytic protein G-D-S-L family
BT_4111	COG0745	RESPONSE REGULATOR receiver
BT_4111	COG2205	protein histidine kinase activity
BT_4111	COG3292	Two component regulator propeller
BT_4113	COG0702	epimerase
BT_4114	COG4771	TonB-dependent receptor
BT_4118	COG3279	Response regulator of the LytR AlgR family
BT_4121	COG4206	TonB-dependent receptor
BT_4121	COG1629	transport
BT_4124	COG2205	protein histidine kinase activity
BT_4124	COG3292	Two component regulator propeller
BT_4124	COG0745	RESPONSE REGULATOR receiver
BT_4125	COG1242	4 iron, 4 sulfur cluster binding
BT_4127	COG0363	glucosamine-6-phosphate deaminase activity
BT_4128	COG0009	L-threonylcarbamoyladenylate synthase
BT_4130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BT_4131	COG0561	phosphatase activity
BT_4135	COG4771	TonB-dependent receptor
BT_4137	COG0745	RESPONSE REGULATOR receiver
BT_4137	COG3292	Two component regulator propeller
BT_4137	COG2205	protein histidine kinase activity
BT_4138	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BT_4139	COG1408	metallophosphoesterase
BT_4143	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BT_4150	COG2755	lipolytic protein G-D-S-L family
BT_4156	COG3250	beta-galactosidase activity
BT_4157	COG3345	alpha-galactosidase
BT_4164	COG4771	TonB-dependent receptor
BT_4165	COG0702	epimerase
BT_4168	COG4771	TonB-dependent receptor
BT_4173	COG2755	lipolytic protein G-D-S-L family
BT_4175	COG3401	FG-GAP repeat protein
BT_4177	COG3254	rhamnose metabolic process
BT_4178	COG0745	RESPONSE REGULATOR receiver
BT_4178	COG3292	Two component regulator propeller
BT_4178	COG0745	RESPONSE REGULATOR receiver
BT_4178	COG2205	protein histidine kinase activity
BT_4178	COG3292	Two component regulator propeller
BT_4178	COG2205	protein histidine kinase activity
BT_4181	COG3250	beta-galactosidase activity
BT_4182	COG0745	RESPONSE REGULATOR receiver
BT_4182	COG3292	Two component regulator propeller
BT_4182	COG2205	protein histidine kinase activity
BT_4184	COG0546	phosphoglycolate phosphatase activity
BT_4188	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BT_4190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BT_4192	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BT_4193	COG1506	peptidase
BT_4193	COG0823	Involved in the tonB-independent uptake of proteins
BT_4203	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BT_4206	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BT_4206	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BT_4207	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BT_4208	COG1078	dGTPase activity
BT_4209	COG0284	orotidine-5'-phosphate decarboxylase activity
BT_4210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BT_4212	COG1704	LemA family
BT_4215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BT_4216	COG2226	methyltransferase
BT_4217	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BT_4218	COG1702	phosphate starvation-inducible protein PhoH
BT_4220	COG2268	Band 7 protein
BT_4236	COG0745	RESPONSE REGULATOR receiver
BT_4236	COG2205	protein histidine kinase activity
BT_4236	COG3292	Two component regulator propeller
BT_4237	COG0101	tRNA pseudouridine synthase activity
BT_4241	COG3250	beta-galactosidase activity
BT_4242	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BT_4243	COG0673	inositol 2-dehydrogenase activity
BT_4247	COG4771	TonB-dependent receptor
BT_4251	COG5434	Belongs to the glycosyl hydrolase 28 family
BT_4252	COG0673	inositol 2-dehydrogenase activity
BT_4253	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BT_4255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BT_4257	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BT_4258	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BT_4259	COG0793	Belongs to the peptidase S41A family
BT_4260	COG2131	deaminase
BT_4262	COG0339	signal peptide processing
BT_4264	COG1970	mechanosensitive ion channel activity
BT_4265	COG0519	Catalyzes the synthesis of GMP from XMP
BT_4265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BT_4267	COG4771	TonB-dependent receptor
BT_4278	COG2433	Pfam Transposase IS66
BT_4280	COG0438	transferase activity, transferring glycosyl groups
BT_4281	COG0463	Glycosyl transferase, family 2
BT_4298	COG4771	TonB-dependent receptor
BT_4304	COG0438	transferase activity, transferring glycosyl groups
BT_4307	COG0297	glycogen (starch) synthase activity
BT_4308	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BT_4309	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BT_4310	COG0543	2 iron, 2 sulfur cluster binding
BT_4312	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BT_4313	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BT_4314	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BT_4317	COG0791	NLP P60 protein
BT_4320	COG0612	Peptidase, M16
BT_4321	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BT_4322	COG1597	lipid kinase activity
BT_4323	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BT_4326	COG1136	(ABC) transporter
BT_4330	COG2211	Major facilitator Superfamily
BT_4331	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BT_4334	COG1674	ftsk spoiiie
BT_4336	COG0492	ferredoxin-NADP+ reductase activity
BT_4337	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_4344	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BT_4344	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BT_4346	COG1234	tRNA 3'-trailer cleavage
BT_4350	COG3956	TIGRFAM MazG family protein
BT_4353	COG0525	valine-tRNA ligase activity
BT_4354	COG2205	protein histidine kinase activity
BT_4354	COG5002	protein histidine kinase activity
BT_4354	COG0784	Response regulator, receiver
BT_4357	COG4206	TonB-dependent receptor
BT_4357	COG1629	transport
BT_4362	COG0653	protein targeting
BT_4363	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
BT_4366	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BT_4370	COG1253	flavin adenine dinucleotide binding
BT_4372	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BT_4374	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BT_4375	COG2204	response regulator
BT_4383	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BT_4383	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BT_4386	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BT_4387	COG0563	adenylate kinase activity
BT_4388	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BT_4389	COG1496	oxidoreductase activity
BT_4394	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_4395	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_4397	COG2814	Major facilitator Superfamily
BT_4398	COG0457	Tetratricopeptide repeat
BT_4399	COG2706	6-phosphogluconolactonase activity
BT_4404	COG4206	TonB-dependent receptor
BT_4404	COG1629	transport
BT_4416	COG3142	Participates in the control of copper homeostasis
BT_4417	COG1418	mRNA catabolic process
BT_4423	COG1070	Carbohydrate kinase
BT_4424	COG1063	alcohol dehydrogenase
BT_4425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BT_4430	COG1333	cytochrome c biogenesis protein
BT_4430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BT_4437	COG3328	transposase activity
BT_4449	COG0673	inositol 2-dehydrogenase activity
BT_4451	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BT_4452	COG2832	Protein of unknown function (DUF454)
BT_4454	COG0602	queuosine metabolic process
BT_4455	COG0247	lactate metabolic process
BT_4456	COG1139	Iron-sulfur cluster binding protein
BT_4458	COG0351	phosphomethylpyrimidine kinase
BT_4460	COG4771	TonB-dependent receptor
BT_4463	COG4589	Belongs to the CDS family
BT_4465	COG2304	oxidoreductase activity
BT_4468	COG1393	Belongs to the ArsC family
BT_4470	COG4206	TonB-dependent receptor
BT_4470	COG1629	transport
BT_4473	COG2233	PERMEase
BT_4474	COG1509	lysine 2,3-aminomutase activity
BT_4476	COG1115	amino acid carrier protein
BT_4484	COG1285	pathogenesis
BT_4486	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BT_4487	COG0741	lytic transglycosylase activity
BT_4487	COG1388	LysM domain
BT_4499	COG0534	Mate efflux family protein
BT_4501	COG0564	pseudouridine synthase activity
BT_4506	COG0346	lactoylglutathione lyase activity
BT_4518	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BT_4519	COG4804	nuclease activity
BT_4520	COG0732	type I restriction modification DNA specificity domain
BT_4535	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BT_4536	COG3586	endonuclease activity
BT_4539	COG3645	SOS response
BT_4544	COG0582	viral genome integration into host DNA
BT_4549	COG4974	Belongs to the 'phage' integrase family
BT_4551	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BT_4552	COG5002	protein histidine kinase activity
BT_4552	COG0784	Response regulator, receiver
BT_4553	COG2910	NAD(P)H-binding
BT_4555	COG4864	UPF0365 protein
BT_4558	COG0037	tRNA processing
BT_4560	COG1477	protein flavinylation
BT_4561	COG1971	Probably functions as a manganese efflux pump
BT_4564	COG0463	Glycosyl transferase, family 2
BT_4566	COG3279	Response regulator of the LytR AlgR family
BT_4571	COG1595	DNA-templated transcription, initiation
BT_4572	COG0148	phosphopyruvate hydratase activity
BT_4574	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BT_4580	COG5433	transposase activity
BT_4581	COG1082	Xylose isomerase domain protein TIM barrel
BT_4582	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BT_4583	COG2195	Cleaves the N-terminal amino acid of tripeptides
BT_4584	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BT_4585	COG4651	solute:proton antiporter activity
BT_4585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BT_4587	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BT_4588	COG0193	aminoacyl-tRNA hydrolase activity
BT_4589	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BT_4591	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BT_4592	COG1862	Preprotein translocase
BT_4594	COG0237	dephospho-CoA kinase activity
BT_4597	COG0542	response to heat
BT_4599	COG0583	DNA-binding transcription factor activity
BT_4602	COG0443	Heat shock 70 kDa protein
BT_4609	COG2855	membrane
BT_4610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BT_4611	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BT_4615	COG0443	Heat shock 70 kDa protein
BT_4628	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BT_4631	COG3119	arylsulfatase activity
BT_4633	COG0702	epimerase
BT_4634	COG4771	TonB-dependent receptor
BT_4637	COG0306	phosphate transporter
BT_4639	COG0586	Pfam SNARE associated Golgi protein
BT_4650	COG0038	chloride channel
BT_4651	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BT_4656	COG3119	arylsulfatase activity
BT_4658	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BT_4659	COG0702	epimerase
BT_4660	COG4771	TonB-dependent receptor
BT_4662	COG5434	Belongs to the glycosyl hydrolase 28 family
BT_4663	COG0745	RESPONSE REGULATOR receiver
BT_4663	COG2205	protein histidine kinase activity
BT_4663	COG3292	Two component regulator propeller
BT_4664	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BT_4665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BT_4667	COG3250	beta-galactosidase activity
BT_4670	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BT_4671	COG4206	TonB-dependent receptor
BT_4671	COG1629	transport
BT_4673	COG5002	protein histidine kinase activity
BT_4678	COG1760	l-serine dehydratase
BT_4679	COG0598	Magnesium transport protein CorA
BT_4680	COG1193	negative regulation of DNA recombination
BT_4681	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BT_4684	COG3250	beta-galactosidase activity
BT_4688	COG0668	transmembrane transport
BT_4689	COG1523	belongs to the glycosyl hydrolase 13 family
BT_4691	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BT_4693	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BT_4695	COG1538	Outer membrane efflux protein
BT_4696	COG0456	acetyltransferase
BT_4698	COG3189	MarR family transcriptional regulator
BT_4699	COG0561	phosphatase activity
BT_4700	COG1169	isochorismate synthase
BT_4701	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BT_4702	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BT_4703	COG4948	Mandelate Racemase Muconate Lactonizing
BT_4707	COG4206	TonB-dependent receptor
BT_4707	COG1629	transport
BT_4715	COG0783	Belongs to the Dps family
BT_4716	COG0583	DNA-binding transcription factor activity
BT_4718	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BT_4722	COG1595	DNA-templated transcription, initiation
BT_4724	COG4771	TonB-dependent receptor
BT_4726	COG0584	glycerophosphoryl diester phosphodiesterase
BT_4727	COG0584	glycerophosphoryl diester phosphodiesterase
BT_4728	COG2271	Major facilitator Superfamily
BT_4736	COG3023	N-Acetylmuramoyl-L-alanine amidase
BT_4737	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BT_4738	COG1882	Formate acetyltransferase
BT_4739	COG4974	Belongs to the 'phage' integrase family
BT_4745	COG5290	Psort location Cytoplasmic, score
BT_4755	COG0326	Molecular chaperone. Has ATPase activity