locus-tag	class	description
INE75_RS00020	COG1373	ATPase (AAA superfamily
INE75_RS00025	COG4771	TonB-dependent receptor
INE75_RS00045	COG4206	TonB-dependent receptor
INE75_RS00045	COG1629	transport
INE75_RS00055	COG1373	ATPase (AAA superfamily
INE75_RS00070	COG4206	TonB-dependent receptor
INE75_RS00070	COG1629	transport
INE75_RS00085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INE75_RS00095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INE75_RS00095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INE75_RS00105	COG0531	amino acid
INE75_RS00115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE75_RS00120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE75_RS00125	COG1162	GTPase activity
INE75_RS00130	COG0233	cytoplasmic translational termination
INE75_RS00135	COG0528	UMP kinase activity
INE75_RS00145	COG0697	spore germination
INE75_RS00150	COG2217	Heavy metal translocating P-type atpase
INE75_RS00155	COG0534	Mate efflux family protein
INE75_RS00165	COG3292	Two component regulator propeller
INE75_RS00165	COG2205	protein histidine kinase activity
INE75_RS00165	COG0745	RESPONSE REGULATOR receiver
INE75_RS00175	COG4771	TonB-dependent receptor
INE75_RS00180	COG0702	epimerase
INE75_RS00190	COG3250	beta-galactosidase activity
INE75_RS00205	COG0792	nuclease activity
INE75_RS00230	COG1183	phosphatidylcholine synthase activity
INE75_RS00235	COG0688	phosphatidylethanolamine metabolic process
INE75_RS00265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INE75_RS00275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INE75_RS00285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE75_RS00295	COG0490	domain, Protein
INE75_RS00295	COG2985	domain, Protein
INE75_RS00300	COG0823	Involved in the tonB-independent uptake of proteins
INE75_RS00300	COG1506	peptidase
INE75_RS00300	COG4946	Tricorn protease homolog
INE75_RS00370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INE75_RS00385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INE75_RS00390	COG0742	ribosomal rna small subunit methyltransferase
INE75_RS00420	COG0739	heme binding
INE75_RS00435	COG1388	LysM domain
INE75_RS00435	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE75_RS00445	COG1475	DNA binding
INE75_RS00450	COG1192	Involved in chromosome partitioning
INE75_RS00465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
INE75_RS00470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE75_RS00485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INE75_RS00500	COG0138	bifunctional purine biosynthesis protein purh
INE75_RS00505	COG1196	nuclear chromosome segregation
INE75_RS00510	COG2239	Acts as a magnesium transporter
INE75_RS00515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INE75_RS00525	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE75_RS00560	COG1119	ATPase activity
INE75_RS00570	COG0668	transmembrane transport
INE75_RS00585	COG1404	Belongs to the peptidase S8 family
INE75_RS00585	COG4412	M6 family metalloprotease domain protein
INE75_RS00590	COG0784	Response regulator, receiver
INE75_RS00590	COG2205	protein histidine kinase activity
INE75_RS00590	COG5002	protein histidine kinase activity
INE75_RS00600	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE75_RS00605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INE75_RS00610	COG0713	ATP synthesis coupled electron transport
INE75_RS00615	COG0839	Belongs to the complex I subunit 6 family
INE75_RS00620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE75_RS00625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INE75_RS00630	COG0649	NAD binding
INE75_RS00630	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE75_RS00635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE75_RS00640	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE75_RS00650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE75_RS00655	COG0569	domain protein
INE75_RS00660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INE75_RS00675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INE75_RS00680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INE75_RS00685	COG0805	protein transport
INE75_RS00700	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
INE75_RS00705	COG3775	system Galactitol-specific IIC component
INE75_RS00720	COG4771	TonB-dependent receptor
INE75_RS00735	COG0546	phosphoglycolate phosphatase activity
INE75_RS00740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
INE75_RS00745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE75_RS00755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INE75_RS00760	COG0823	Involved in the tonB-independent uptake of proteins
INE75_RS00760	COG1506	peptidase
INE75_RS00765	COG4821	SIS domain
INE75_RS00770	COG2814	Major facilitator Superfamily
INE75_RS00780	COG1242	4 iron, 4 sulfur cluster binding
INE75_RS00790	COG0363	glucosamine-6-phosphate deaminase activity
INE75_RS00835	COG0681	Belongs to the peptidase S26 family
INE75_RS00945	COG0628	permease
INE75_RS00950	COG0009	L-threonylcarbamoyladenylate synthase
INE75_RS00955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE75_RS00960	COG0561	phosphatase activity
INE75_RS00975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE75_RS00990	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS01000	COG1073	alpha beta
INE75_RS01015	COG3487	Iron-regulated protein
INE75_RS01040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE75_RS01040	COG1333	cytochrome c biogenesis protein
INE75_RS01065	COG1629	transport
INE75_RS01065	COG4206	TonB-dependent receptor
INE75_RS01080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE75_RS01090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE75_RS01095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INE75_RS01095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
INE75_RS01100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE75_RS01105	COG1078	dGTPase activity
INE75_RS01110	COG0284	orotidine-5'-phosphate decarboxylase activity
INE75_RS01115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INE75_RS01120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INE75_RS01125	COG1704	LemA family
INE75_RS01140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INE75_RS01150	COG2226	methyltransferase
INE75_RS01155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INE75_RS01160	COG1702	phosphate starvation-inducible protein PhoH
INE75_RS01175	COG1496	oxidoreductase activity
INE75_RS01180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE75_RS01185	COG0563	adenylate kinase activity
INE75_RS01190	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INE75_RS01195	COG1940	carbohydrate kinase activity
INE75_RS01210	COG2814	Major facilitator Superfamily
INE75_RS01220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE75_RS01260	COG4771	TonB-dependent receptor
INE75_RS01265	COG0702	epimerase
INE75_RS01285	COG3345	alpha-galactosidase
INE75_RS01290	COG1082	Xylose isomerase domain protein TIM barrel
INE75_RS01305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INE75_RS01305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
INE75_RS01320	COG0101	tRNA pseudouridine synthase activity
INE75_RS01330	COG1956	GAF domain-containing protein
INE75_RS01340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE75_RS01350	COG2755	lipolytic protein G-D-S-L family
INE75_RS01350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE75_RS01375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
INE75_RS01400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INE75_RS01405	COG0793	Belongs to the peptidase S41A family
INE75_RS01410	COG2131	deaminase
INE75_RS01420	COG0339	signal peptide processing
INE75_RS01435	COG1970	mechanosensitive ion channel activity
INE75_RS01440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INE75_RS01440	COG0519	Catalyzes the synthesis of GMP from XMP
INE75_RS01445	COG0519	Catalyzes the synthesis of GMP from XMP
INE75_RS01470	COG0438	transferase activity, transferring glycosyl groups
INE75_RS01485	COG0297	glycogen (starch) synthase activity
INE75_RS01490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INE75_RS01495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INE75_RS01505	COG0543	2 iron, 2 sulfur cluster binding
INE75_RS01520	COG3279	Response regulator of the LytR AlgR family
INE75_RS01525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INE75_RS01530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INE75_RS01535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INE75_RS01550	COG1191	sigma factor activity
INE75_RS01560	COG3537	Alpha-1,2-mannosidase
INE75_RS01565	COG1629	transport
INE75_RS01565	COG4206	TonB-dependent receptor
INE75_RS01590	COG3537	Alpha-1,2-mannosidase
INE75_RS01600	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE75_RS01605	COG3537	Alpha-1,2-mannosidase
INE75_RS01620	COG0791	NLP P60 protein
INE75_RS01635	COG0612	Peptidase, M16
INE75_RS01640	COG2877	3-deoxy-8-phosphooctulonate synthase activity
INE75_RS01645	COG1597	lipid kinase activity
INE75_RS01650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE75_RS01655	COG0534	Mate efflux family protein
INE75_RS01665	COG3973	AAA domain
INE75_RS01690	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
INE75_RS01695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
INE75_RS01700	COG1663	tetraacyldisaccharide 4'-kinase activity
INE75_RS01705	COG0616	signal peptide processing
INE75_RS01745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INE75_RS01750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INE75_RS01755	COG0066	3-isopropylmalate dehydratase activity
INE75_RS01775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INE75_RS01785	COG0514	ATP-dependent DNA helicase (RecQ)
INE75_RS01805	COG0735	belongs to the Fur family
INE75_RS01810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INE75_RS01830	COG0124	histidyl-tRNA synthetase
INE75_RS01850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INE75_RS01855	COG0459	protein refolding
INE75_RS01875	COG0484	heat shock protein binding
INE75_RS01895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INE75_RS01900	COG2086	electron transfer activity
INE75_RS01920	COG4771	TonB-dependent receptor
INE75_RS01930	COG1621	beta-fructofuranosidase activity
INE75_RS01935	COG1621	beta-fructofuranosidase activity
INE75_RS01945	COG1621	beta-fructofuranosidase activity
INE75_RS01950	COG1621	beta-fructofuranosidase activity
INE75_RS01965	COG2205	protein histidine kinase activity
INE75_RS01965	COG3292	Two component regulator propeller
INE75_RS01965	COG0745	RESPONSE REGULATOR receiver
INE75_RS01985	COG1649	PFAM Uncharacterised BCR, COG1649
INE75_RS01990	COG1966	Carbon starvation protein
INE75_RS02025	COG5002	protein histidine kinase activity
INE75_RS02025	COG0784	Response regulator, receiver
INE75_RS02030	COG1649	PFAM Uncharacterised BCR, COG1649
INE75_RS02075	COG1803	Methylglyoxal synthase
INE75_RS02080	COG0010	Belongs to the arginase family
INE75_RS02085	COG0058	SHG alpha-glucan phosphorylase activity
INE75_RS02090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE75_RS02090	COG4651	solute:proton antiporter activity
INE75_RS02095	COG0205	6-phosphofructokinase activity
INE75_RS02110	COG0588	phosphoglycerate mutase activity
INE75_RS02115	COG1830	Aldolase
INE75_RS02125	COG2095	MarC family integral membrane protein
INE75_RS02140	COG0655	NAD(P)H dehydrogenase (quinone) activity
INE75_RS02150	COG0667	Aldo Keto reductase
INE75_RS02195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE75_RS02200	COG4771	TonB-dependent receptor
INE75_RS02210	COG2706	6-phosphogluconolactonase activity
INE75_RS02215	COG2207	Transcriptional regulator
INE75_RS02285	COG4974	Belongs to the 'phage' integrase family
INE75_RS02290	COG3292	Two component regulator propeller
INE75_RS02290	COG2205	protein histidine kinase activity
INE75_RS02290	COG0745	RESPONSE REGULATOR receiver
INE75_RS02300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE75_RS02305	COG1280	lysine exporter protein (LysE YggA)
INE75_RS02335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
INE75_RS02350	COG0511	ligase activity, forming carbon-carbon bonds
INE75_RS02365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE75_RS02370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE75_RS02375	COG1554	hydrolase, family 65, central catalytic
INE75_RS02385	COG1609	Transcriptional regulator
INE75_RS02395	COG3250	beta-galactosidase activity
INE75_RS02400	COG4206	TonB-dependent receptor
INE75_RS02400	COG1629	transport
INE75_RS02415	COG5433	transposase activity
INE75_RS02440	COG0778	Nitroreductase
INE75_RS02455	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
INE75_RS02460	COG0424	maF-like protein
INE75_RS02475	COG0126	phosphoglycerate kinase activity
INE75_RS02480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INE75_RS02490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INE75_RS02510	COG2223	nitrite transmembrane transporter activity
INE75_RS02515	COG4413	Urea transporter
INE75_RS02530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INE75_RS02535	COG1523	belongs to the glycosyl hydrolase 13 family
INE75_RS02540	COG1119	ATPase activity
INE75_RS02555	COG0671	phosphoesterase, PA-phosphatase related
INE75_RS02570	COG5002	protein histidine kinase activity
INE75_RS02580	COG0668	transmembrane transport
INE75_RS02590	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE75_RS02605	COG3142	Participates in the control of copper homeostasis
INE75_RS02610	COG1418	mRNA catabolic process
INE75_RS02655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE75_RS02660	COG2832	Protein of unknown function (DUF454)
INE75_RS02665	COG0351	phosphomethylpyrimidine kinase
INE75_RS02680	COG0602	queuosine metabolic process
INE75_RS02695	COG1509	lysine 2,3-aminomutase activity
INE75_RS02705	COG1115	amino acid carrier protein
INE75_RS02730	COG1285	pathogenesis
INE75_RS02735	COG1388	LysM domain
INE75_RS02735	COG0741	lytic transglycosylase activity
INE75_RS02750	COG2205	protein histidine kinase activity
INE75_RS02750	COG0784	Response regulator, receiver
INE75_RS02750	COG5002	protein histidine kinase activity
INE75_RS02795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
INE75_RS02800	COG0346	lactoylglutathione lyase activity
INE75_RS02805	COG1247	-acetyltransferase
INE75_RS02810	COG0564	pseudouridine synthase activity
INE75_RS02815	COG2205	protein histidine kinase activity
INE75_RS02815	COG5002	protein histidine kinase activity
INE75_RS02815	COG0784	Response regulator, receiver
INE75_RS02825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
INE75_RS02830	COG0542	response to heat
INE75_RS02835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
INE75_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
INE75_RS02880	COG1253	flavin adenine dinucleotide binding
INE75_RS02920	COG1757	Na H antiporter
INE75_RS02925	COG2814	Major facilitator Superfamily
INE75_RS02930	COG0745	RESPONSE REGULATOR receiver
INE75_RS02940	COG0813	purine-nucleoside phosphorylase activity
INE75_RS02945	COG4864	UPF0365 protein
INE75_RS02960	COG0037	tRNA processing
INE75_RS02970	COG1477	protein flavinylation
INE75_RS02975	COG1971	Probably functions as a manganese efflux pump
INE75_RS02990	COG0463	Glycosyl transferase, family 2
INE75_RS03030	COG0702	epimerase
INE75_RS03055	COG0148	phosphopyruvate hydratase activity
INE75_RS03065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INE75_RS03075	COG1082	Xylose isomerase domain protein TIM barrel
INE75_RS03090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INE75_RS03095	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE75_RS03100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
INE75_RS03110	COG0254	rRNA binding
INE75_RS03120	COG0191	fructose-bisphosphate aldolase activity
INE75_RS03125	COG0366	Alpha amylase catalytic
INE75_RS03135	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
INE75_RS03140	COG0511	ligase activity, forming carbon-carbon bonds
INE75_RS03150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE75_RS03165	COG2204	response regulator
INE75_RS03170	COG4191	Histidine kinase
INE75_RS03205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INE75_RS03215	COG1979	alcohol dehydrogenase
INE75_RS03220	COG1530	ribonuclease E activity
INE75_RS03225	COG0776	regulation of translation
INE75_RS03235	COG0629	single-stranded DNA binding
INE75_RS03250	COG3033	Beta-eliminating lyase
INE75_RS03255	COG5002	protein histidine kinase activity
INE75_RS03260	COG0745	RESPONSE REGULATOR receiver
INE75_RS03270	COG4771	TonB-dependent receptor
INE75_RS03290	COG0488	(ABC) transporter
INE75_RS03310	COG3591	Belongs to the peptidase S1B family
INE75_RS03315	COG3591	Belongs to the peptidase S1B family
INE75_RS03320	COG0641	radical SAM
INE75_RS03335	COG1408	metallophosphoesterase
INE75_RS03350	COG1410	methionine synthase
INE75_RS03350	COG0646	methionine synthase
INE75_RS03355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INE75_RS03360	COG0463	Glycosyl transferase, family 2
INE75_RS03365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INE75_RS03375	COG1032	radical SAM domain protein
INE75_RS03400	COG0363	glucosamine-6-phosphate deaminase activity
INE75_RS03410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE75_RS03455	COG3757	hydrolase, family 25
INE75_RS03460	COG2264	protein methyltransferase activity
INE75_RS03495	COG1592	Rubrerythrin
INE75_RS03495	COG1773	rubredoxin
INE75_RS03505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INE75_RS03505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE75_RS03510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE75_RS03550	COG0698	ribose 5-phosphate isomerase
INE75_RS03565	COG1070	Carbohydrate kinase
INE75_RS03570	COG2160	L-arabinose isomerase activity
INE75_RS03600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INE75_RS03615	COG1482	cell wall glycoprotein biosynthetic process
INE75_RS03635	COG0513	Belongs to the DEAD box helicase family
INE75_RS03650	COG1218	3'(2'),5'-bisphosphate nucleotidase
INE75_RS03655	COG0471	metal ion transport
INE75_RS03655	COG3273	potassium ion transport
INE75_RS03660	COG0529	Catalyzes the synthesis of activated sulfate
INE75_RS03665	COG0175	sulfate reduction
INE75_RS03670	COG2895	sulfate adenylyltransferase (ATP) activity
INE75_RS03710	COG4974	Belongs to the 'phage' integrase family
INE75_RS03740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INE75_RS03745	COG0242	peptide deformylase activity
INE75_RS03755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INE75_RS03760	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INE75_RS03765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INE75_RS03770	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INE75_RS03775	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE75_RS03780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
INE75_RS03780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE75_RS03780	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE75_RS03780	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE75_RS03790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INE75_RS03795	COG0823	Involved in the tonB-independent uptake of proteins
INE75_RS03835	COG0484	heat shock protein binding
INE75_RS03840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INE75_RS03845	COG0488	(ABC) transporter
INE75_RS03860	COG2183	response to ionizing radiation
INE75_RS03865	COG2202	Pas domain
INE75_RS03865	COG2205	protein histidine kinase activity
INE75_RS03880	COG4771	TonB-dependent receptor
INE75_RS03885	COG4977	sequence-specific DNA binding
INE75_RS03885	COG1917	Cupin 2, conserved barrel domain protein
INE75_RS03915	COG0438	transferase activity, transferring glycosyl groups
INE75_RS03920	COG0438	transferase activity, transferring glycosyl groups
INE75_RS03935	COG0438	transferase activity, transferring glycosyl groups
INE75_RS03945	COG0438	transferase activity, transferring glycosyl groups
INE75_RS03965	COG2244	polysaccharide biosynthetic process
INE75_RS04140	COG3617	BRO family, N-terminal domain
INE75_RS04220	COG1028	Short-chain dehydrogenase reductase Sdr
INE75_RS04225	COG0525	valine-tRNA ligase activity
INE75_RS04245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
INE75_RS04255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INE75_RS04310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE75_RS04320	COG1309	transcriptional regulator
INE75_RS04330	COG0739	heme binding
INE75_RS04400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE75_RS04405	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE75_RS04505	COG1475	DNA binding
INE75_RS04560	COG0534	Mate efflux family protein
INE75_RS04615	COG0306	phosphate transporter
INE75_RS04625	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
INE75_RS04635	COG3119	arylsulfatase activity
INE75_RS04640	COG0318	PFAM AMP-dependent synthetase and ligase
INE75_RS04650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE75_RS04660	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
INE75_RS04665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INE75_RS04670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INE75_RS04675	COG0363	glucosamine-6-phosphate deaminase activity
INE75_RS04685	COG0259	pyridoxamine-phosphate oxidase activity
INE75_RS04695	COG3279	Response regulator of the LytR AlgR family
INE75_RS04705	COG1136	(ABC) transporter
INE75_RS04705	COG0577	efflux transmembrane transporter activity
INE75_RS04710	COG1136	(ABC) transporter
INE75_RS04740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INE75_RS04750	COG0534	Mate efflux family protein
INE75_RS04760	COG1177	transmembrane transport
INE75_RS04765	COG1176	ABC-type spermidine putrescine transport system, permease component I
INE75_RS04770	COG3842	ATPase activity
INE75_RS04775	COG4221	oxidoreductase activity
INE75_RS04790	COG0488	(ABC) transporter
INE75_RS04810	COG0513	Belongs to the DEAD box helicase family
INE75_RS04815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INE75_RS04820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE75_RS04835	COG0545	Peptidyl-prolyl cis-trans isomerase
INE75_RS04845	COG0534	Mate efflux family protein
INE75_RS04850	COG1929	Belongs to the glycerate kinase type-1 family
INE75_RS04855	COG1739	Uncharacterized protein family UPF0029
INE75_RS04865	COG0778	Nitroreductase
INE75_RS04875	COG1725	Transcriptional regulator
INE75_RS04885	COG1131	(ABC) transporter
INE75_RS04895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE75_RS04895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE75_RS04900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INE75_RS04905	COG0357	Ribosomal RNA small subunit methyltransferase G
INE75_RS04930	COG2217	Heavy metal translocating P-type atpase
INE75_RS04940	COG4772	TonB-dependent receptor
INE75_RS04945	COG0321	lipoyl(octanoyl) transferase activity
INE75_RS04975	COG1442	glycosyl transferase family 8
INE75_RS04975	COG1216	Glycosyl transferase, family 2
INE75_RS04985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE75_RS05005	COG1250	3-hydroxyacyl-CoA dehydrogenase
INE75_RS05010	COG0110	maltose O-acetyltransferase activity
INE75_RS05025	COG1215	transferase activity, transferring glycosyl groups
INE75_RS05030	COG2244	polysaccharide biosynthetic process
INE75_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
INE75_RS05050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INE75_RS05055	COG0438	transferase activity, transferring glycosyl groups
INE75_RS05070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INE75_RS05075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE75_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
INE75_RS05095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE75_RS05120	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INE75_RS05125	COG0673	inositol 2-dehydrogenase activity
INE75_RS05130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
INE75_RS05170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INE75_RS05175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE75_RS05195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE75_RS05195	COG0072	phenylalanine-tRNA ligase activity
INE75_RS05200	COG0217	transcriptional regulatory protein
INE75_RS05210	COG1914	H( )-stimulated, divalent metal cation uptake system
INE75_RS05215	COG0708	Exodeoxyribonuclease III
INE75_RS05230	COG0481	GTPase activity
INE75_RS05235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INE75_RS05240	COG5002	protein histidine kinase activity
INE75_RS05255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE75_RS05260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INE75_RS05280	COG0612	Peptidase, M16
INE75_RS05295	COG0784	Response regulator, receiver
INE75_RS05295	COG2205	protein histidine kinase activity
INE75_RS05315	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE75_RS05320	COG1805	sodium ion transport
INE75_RS05325	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE75_RS05335	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE75_RS05350	COG0024	Methionine aminopeptidase
INE75_RS05360	COG0420	3'-5' exonuclease activity
INE75_RS05385	COG2814	Major facilitator Superfamily
INE75_RS05400	COG0564	pseudouridine synthase activity
INE75_RS05405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INE75_RS05410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INE75_RS05410	COG0574	Belongs to the PEP-utilizing enzyme family
INE75_RS05475	COG1192	Involved in chromosome partitioning
INE75_RS05590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE75_RS05655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INE75_RS05730	COG0358	DNA primase activity
INE75_RS05755	COG0784	Response regulator, receiver
INE75_RS05755	COG2205	protein histidine kinase activity
INE75_RS05755	COG5002	protein histidine kinase activity
INE75_RS05760	COG0352	thiamine-phosphate diphosphorylase activity
INE75_RS05820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INE75_RS05835	COG1678	Uncharacterized ACR, COG1678
INE75_RS05845	COG4771	TonB-dependent receptor
INE75_RS05875	COG0110	maltose O-acetyltransferase activity
INE75_RS05885	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE75_RS05900	COG0738	Major facilitator superfamily
INE75_RS05910	COG2059	Chromate
INE75_RS05920	COG3969	phosphoadenosine phosphosulfate
INE75_RS05925	COG1475	DNA binding
INE75_RS05930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE75_RS05945	COG1074	ATP-dependent DNA helicase activity
INE75_RS05955	COG0556	nucleotide-excision repair
INE75_RS05960	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE75_RS05990	COG3942	CHAP domain
INE75_RS05990	COG1388	LysM domain
INE75_RS05995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INE75_RS06000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INE75_RS06005	COG3104	oligopeptide transport
INE75_RS06020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE75_RS06030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INE75_RS06050	COG1695	Transcriptional regulator
INE75_RS06070	COG1086	Polysaccharide biosynthesis protein
INE75_RS06075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE75_RS06080	COG1083	cytidylyl-transferase
INE75_RS06100	COG0151	Belongs to the GarS family
INE75_RS06105	COG2089	acid synthase
INE75_RS06140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
INE75_RS06210	COG3475	LICD family
INE75_RS06215	COG0438	transferase activity, transferring glycosyl groups
INE75_RS06220	COG1216	Glycosyl transferase, family 2
INE75_RS06235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE75_RS06250	COG3250	beta-galactosidase activity
INE75_RS06255	COG2755	lipolytic protein G-D-S-L family
INE75_RS06255	COG0657	acetylesterase activity
INE75_RS06280	COG3059	membrane
INE75_RS06285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE75_RS06300	COG1120	ATPase activity
INE75_RS06305	COG0534	Mate efflux family protein
INE75_RS06310	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
INE75_RS06320	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
INE75_RS06350	COG4771	TonB-dependent receptor
INE75_RS06370	COG1429	ligase activity, forming nitrogen-metal bonds
INE75_RS06390	COG4771	TonB-dependent receptor
INE75_RS06395	COG0439	Biotin carboxylase
INE75_RS06405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE75_RS06415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
INE75_RS06425	COG1797	cobyrinic acid a,c-diamide synthase activity
INE75_RS06580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE75_RS06640	COG0739	heme binding
INE75_RS06640	COG0741	lytic transglycosylase activity
INE75_RS06640	COG1196	nuclear chromosome segregation
INE75_RS06645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INE75_RS06730	COG3209	COG3209 Rhs family protein
INE75_RS06740	COG3209	COG3209 Rhs family protein
INE75_RS06810	COG0542	response to heat
INE75_RS06850	COG0629	single-stranded DNA binding
INE75_RS06855	COG1192	Involved in chromosome partitioning
INE75_RS06870	COG1475	DNA binding
INE75_RS07100	COG4974	Belongs to the 'phage' integrase family
INE75_RS07135	COG2096	Adenosyltransferase
INE75_RS07140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
INE75_RS07160	COG1492	cobalamin metabolic process
INE75_RS07170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
INE75_RS07175	COG2205	protein histidine kinase activity
INE75_RS07175	COG2202	Pas domain
INE75_RS07180	COG2205	protein histidine kinase activity
INE75_RS07180	COG2202	Pas domain
INE75_RS07190	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
INE75_RS07195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
INE75_RS07210	COG2186	Transcriptional regulator
INE75_RS07215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE75_RS07220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE75_RS07225	COG4771	TonB-dependent receptor
INE75_RS07230	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE75_RS07250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
INE75_RS07255	COG2731	YhcH YjgK YiaL family protein
INE75_RS07260	COG0442	prolyl-tRNA aminoacylation
INE75_RS07335	COG1216	Glycosyl transferase, family 2
INE75_RS07345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE75_RS07350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INE75_RS07355	COG0438	transferase activity, transferring glycosyl groups
INE75_RS07370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE75_RS07375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE75_RS07385	COG0823	Involved in the tonB-independent uptake of proteins
INE75_RS07385	COG1506	peptidase
INE75_RS07390	COG0534	Mate efflux family protein
INE75_RS07400	COG0504	CTP synthase activity
INE75_RS07420	COG4656	Part of a membrane complex involved in electron transport
INE75_RS07425	COG4658	electron transport chain
INE75_RS07430	COG4659	FMN binding
INE75_RS07435	COG4660	Part of a membrane complex involved in electron transport
INE75_RS07440	COG4657	Part of a membrane complex involved in electron transport
INE75_RS07445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INE75_RS07465	COG0356	it plays a direct role in the translocation of protons across the membrane
INE75_RS07470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE75_RS07475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INE75_RS07480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE75_RS07485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INE75_RS07490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INE75_RS07495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE75_RS07530	COG2759	Belongs to the formate--tetrahydrofolate ligase family
INE75_RS07535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INE75_RS07550	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
INE75_RS07555	COG0540	Belongs to the ATCase OTCase family
INE75_RS07560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INE75_RS07570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
INE75_RS07585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INE75_RS07590	COG2205	protein histidine kinase activity
INE75_RS07605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
INE75_RS07635	COG2433	Pfam Transposase IS66
INE75_RS07715	COG3328	transposase activity
INE75_RS07910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INE75_RS07955	COG0351	phosphomethylpyrimidine kinase
INE75_RS07960	COG0352	thiamine-phosphate diphosphorylase activity
INE75_RS07975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
INE75_RS07980	COG2022	thiamine diphosphate biosynthetic process
INE75_RS07985	COG0352	thiamine-phosphate diphosphorylase activity
INE75_RS08000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INE75_RS08015	COG2115	Belongs to the xylose isomerase family
INE75_RS08020	COG2814	Major facilitator Superfamily
INE75_RS08020	COG0477	Major facilitator Superfamily
INE75_RS08025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE75_RS08025	COG3153	acetyltransferase
INE75_RS08055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INE75_RS08065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INE75_RS08080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE75_RS08100	COG1252	NADH dehydrogenase
INE75_RS08110	COG2194	sulfuric ester hydrolase activity
INE75_RS08130	COG2249	NAD(P)H dehydrogenase (quinone) activity
INE75_RS08140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE75_RS08155	COG1904	glucuronate isomerase
INE75_RS08160	COG1609	Transcriptional regulator
INE75_RS08165	COG0246	Mannitol dehydrogenase
INE75_RS08200	COG0513	Belongs to the DEAD box helicase family
INE75_RS08205	COG0560	Phosphoserine phosphatase
INE75_RS08205	COG3830	Belongs to the UPF0237 family
INE75_RS08220	COG0343	queuine tRNA-ribosyltransferase activity
INE75_RS08225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
INE75_RS08230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
INE75_RS08285	COG1136	(ABC) transporter
INE75_RS08325	COG0501	Belongs to the peptidase M48B family
INE75_RS08330	COG0156	8-amino-7-oxononanoate synthase activity
INE75_RS08335	COG1597	lipid kinase activity
INE75_RS08340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INE75_RS08355	COG2957	Belongs to the agmatine deiminase family
INE75_RS08365	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
INE75_RS08370	COG0390	transport system, permease component
INE75_RS08385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INE75_RS08430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE75_RS08445	COG0543	2 iron, 2 sulfur cluster binding
INE75_RS08450	COG0167	dihydroorotate dehydrogenase activity
INE75_RS08455	COG0336	Belongs to the RNA methyltransferase TrmD family
INE75_RS08460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INE75_RS08465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE75_RS08500	COG0542	response to heat
INE75_RS08545	COG2304	oxidoreductase activity
INE75_RS08560	COG0714	Associated with various cellular activities
INE75_RS08575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE75_RS08580	COG0552	protein localization to endoplasmic reticulum
INE75_RS08590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INE75_RS08595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INE75_RS08600	COG1546	Belongs to the CinA family
INE75_RS08600	COG1058	Belongs to the CinA family
INE75_RS08605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INE75_RS08615	COG0305	Participates in initiation and elongation during chromosome replication
INE75_RS08620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
INE75_RS08630	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
INE75_RS08640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INE75_RS08645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
INE75_RS08655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
INE75_RS08660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE75_RS08665	COG0534	Mate efflux family protein
INE75_RS08680	COG1136	(ABC) transporter
INE75_RS08680	COG0577	efflux transmembrane transporter activity
INE75_RS08685	COG1136	(ABC) transporter
INE75_RS08710	COG2205	protein histidine kinase activity
INE75_RS08715	COG3263	regulation of cellular component size
INE75_RS08720	COG0318	PFAM AMP-dependent synthetase and ligase
INE75_RS08725	COG1082	Xylose isomerase domain protein TIM barrel
INE75_RS08745	COG0702	epimerase
INE75_RS08750	COG4771	TonB-dependent receptor
INE75_RS08765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INE75_RS08775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE75_RS08775	COG2755	lipolytic protein G-D-S-L family
INE75_RS08785	COG0842	Transport permease protein
INE75_RS08790	COG1131	(ABC) transporter
INE75_RS08805	COG2207	Transcriptional regulator
INE75_RS08805	COG1917	Cupin 2, conserved barrel domain protein
INE75_RS08810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INE75_RS08815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE75_RS08820	COG0505	Belongs to the CarA family
INE75_RS08830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INE75_RS08835	COG0067	glutamate synthase
INE75_RS08835	COG0069	glutamate synthase activity
INE75_RS08835	COG0070	glutamate synthase
INE75_RS08845	COG0367	asparagine synthase
INE75_RS08870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE75_RS08875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE75_RS08885	COG1216	Glycosyl transferase, family 2
INE75_RS08900	COG0438	transferase activity, transferring glycosyl groups
INE75_RS08935	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
INE75_RS08935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
INE75_RS08995	COG0436	Aminotransferase
INE75_RS09005	COG0347	Belongs to the P(II) protein family
INE75_RS09010	COG0004	ammonium transporteR
INE75_RS09030	COG0133	tryptophan synthase activity
INE75_RS09035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INE75_RS09040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INE75_RS09040	COG0512	Glutamine amidotransferase of anthranilate synthase
INE75_RS09045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INE75_RS09050	COG0134	indole-3-glycerol-phosphate synthase activity
INE75_RS09055	COG0135	phosphoribosylanthranilate isomerase activity
INE75_RS09060	COG0159	tryptophan synthase activity
INE75_RS09065	COG0252	asparaginase activity
INE75_RS09075	COG0745	RESPONSE REGULATOR receiver
INE75_RS09165	COG1215	transferase activity, transferring glycosyl groups
INE75_RS09170	COG0438	transferase activity, transferring glycosyl groups
INE75_RS09180	COG0438	transferase activity, transferring glycosyl groups
INE75_RS09185	COG1442	glycosyl transferase family 8
INE75_RS09185	COG1216	Glycosyl transferase, family 2
INE75_RS09190	COG1216	Glycosyl transferase, family 2
INE75_RS09220	COG1609	Transcriptional regulator
INE75_RS09225	COG2721	sulfolactate sulfo-lyase activity
INE75_RS09235	COG0228	four-way junction DNA binding
INE75_RS09240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE75_RS09270	COG0588	phosphoglycerate mutase activity
INE75_RS09280	COG0716	FMN binding
INE75_RS09285	COG0058	SHG alpha-glucan phosphorylase activity
INE75_RS09315	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
INE75_RS09390	COG0582	viral genome integration into host DNA
INE75_RS09455	COG0305	Participates in initiation and elongation during chromosome replication
INE75_RS09485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
INE75_RS09485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE75_RS09500	COG2226	methyltransferase
INE75_RS09510	COG1215	transferase activity, transferring glycosyl groups
INE75_RS09515	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE75_RS09520	COG0436	Aminotransferase
INE75_RS09530	COG0784	Response regulator, receiver
INE75_RS09530	COG2205	protein histidine kinase activity
INE75_RS09550	COG0577	efflux transmembrane transporter activity
INE75_RS09565	COG0577	efflux transmembrane transporter activity
INE75_RS09565	COG1136	(ABC) transporter
INE75_RS09570	COG1136	(ABC) transporter
INE75_RS09580	COG0577	efflux transmembrane transporter activity
INE75_RS09585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE75_RS09590	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE75_RS09595	COG0295	cytidine deaminase activity
INE75_RS09600	COG0488	(ABC) transporter
INE75_RS09605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INE75_RS09620	COG4771	TonB-dependent receptor
INE75_RS09700	COG0484	heat shock protein binding
INE75_RS09740	COG0305	Participates in initiation and elongation during chromosome replication
INE75_RS09740	COG0358	DNA primase activity
INE75_RS09855	COG1373	ATPase (AAA superfamily
INE75_RS09905	COG3344	reverse transcriptase
INE75_RS09935	COG1373	ATPase (AAA superfamily
INE75_RS09955	COG0551	DNA topoisomerase type I activity
INE75_RS09955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE75_RS10045	COG0784	Response regulator, receiver
INE75_RS10045	COG2198	Histidine kinase
INE75_RS10045	COG5002	protein histidine kinase activity
INE75_RS10050	COG2204	response regulator
INE75_RS10075	COG4974	Belongs to the 'phage' integrase family
INE75_RS10080	COG0582	viral genome integration into host DNA
INE75_RS10085	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
INE75_RS10125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE75_RS10135	COG0739	heme binding
INE75_RS10140	COG0686	Belongs to the AlaDH PNT family
INE75_RS10150	COG0076	glutamate decarboxylase activity
INE75_RS10155	COG2066	Belongs to the glutaminase family
INE75_RS10165	COG0531	amino acid
INE75_RS10190	COG1595	DNA-templated transcription, initiation
INE75_RS10215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
INE75_RS10230	COG0446	pyridine nucleotide-disulphide oxidoreductase
INE75_RS10245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INE75_RS10250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INE75_RS10260	COG4948	Mandelate Racemase Muconate Lactonizing
INE75_RS10290	COG0704	Plays a role in the regulation of phosphate uptake
INE75_RS10295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INE75_RS10300	COG0581	inorganic phosphate transmembrane transporter activity
INE75_RS10305	COG0573	inorganic phosphate transmembrane transporter activity
INE75_RS10310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INE75_RS10315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE75_RS10325	COG0586	Pfam SNARE associated Golgi protein
INE75_RS10330	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
INE75_RS10345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE75_RS10365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INE75_RS10370	COG3958	Transketolase
INE75_RS10375	COG3959	Transketolase, thiamine diphosphate binding domain
INE75_RS10380	COG1028	Short-chain dehydrogenase reductase Sdr
INE75_RS10400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE75_RS10470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INE75_RS10475	COG0167	dihydroorotate dehydrogenase activity
INE75_RS10485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
INE75_RS10505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE75_RS10510	COG0497	DNA recombination
INE75_RS10525	COG0592	DNA-directed DNA polymerase activity
INE75_RS10540	COG0321	lipoyl(octanoyl) transferase activity
INE75_RS10540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE75_RS10560	COG0156	8-amino-7-oxononanoate synthase activity
INE75_RS10570	COG0019	diaminopimelate decarboxylase activity
INE75_RS10575	COG0527	aspartate kinase activity
INE75_RS10580	COG2884	Cell division ATP-binding protein ftsE
INE75_RS10585	COG0140	phosphoribosyl-ATP diphosphatase activity
INE75_RS10585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INE75_RS10590	COG0107	imidazoleglycerol-phosphate synthase activity
INE75_RS10595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INE75_RS10600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INE75_RS10605	COG0788	formyltetrahydrofolate deformylase activity
INE75_RS10625	COG0561	phosphatase activity
INE75_RS10630	COG1609	Transcriptional regulator
INE75_RS10630	COG2207	Transcriptional regulator
INE75_RS10640	COG0714	Associated with various cellular activities
INE75_RS10675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
INE75_RS10690	COG1151	hydroxylamine reductase activity
INE75_RS10710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE75_RS10720	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
INE75_RS10745	COG0148	phosphopyruvate hydratase activity
INE75_RS10750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
INE75_RS10755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
INE75_RS10765	COG1629	transport
INE75_RS10765	COG4206	TonB-dependent receptor
INE75_RS10770	COG0702	epimerase
INE75_RS10795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE75_RS10800	COG1741	Belongs to the pirin family
INE75_RS10815	COG0346	lactoylglutathione lyase activity
INE75_RS10840	COG1918	ferrous iron import across plasma membrane
INE75_RS10840	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INE75_RS10845	COG0037	tRNA processing
INE75_RS10860	COG3119	arylsulfatase activity
INE75_RS10865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INE75_RS10870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INE75_RS10885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INE75_RS10895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE75_RS10925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INE75_RS11030	COG2433	Pfam Transposase IS66
INE75_RS11185	COG3344	reverse transcriptase
INE75_RS11220	COG3275	phosphorelay sensor kinase activity
INE75_RS11265	COG0551	DNA topoisomerase type I activity
INE75_RS11265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE75_RS11305	COG1040	competence protein
INE75_RS11315	COG4974	Belongs to the 'phage' integrase family
INE75_RS11320	COG1309	transcriptional regulator
INE75_RS11325	COG4974	Belongs to the 'phage' integrase family
INE75_RS11390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE75_RS11390	COG0551	DNA topoisomerase type I activity
INE75_RS11535	COG4974	Belongs to the 'phage' integrase family
INE75_RS11545	COG1193	negative regulation of DNA recombination
INE75_RS11550	COG1760	l-serine dehydratase
INE75_RS11565	COG5002	protein histidine kinase activity
INE75_RS11565	COG3850	Histidine kinase
INE75_RS11570	COG0745	RESPONSE REGULATOR receiver
INE75_RS11615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE75_RS11620	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
INE75_RS11655	COG4139	cobalamin transport
INE75_RS11675	COG0561	phosphatase activity
INE75_RS11685	COG0443	Heat shock 70 kDa protein
INE75_RS11710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
INE75_RS11715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INE75_RS11730	COG1595	DNA-templated transcription, initiation
INE75_RS11750	COG2855	membrane
INE75_RS11755	COG0583	DNA-binding transcription factor activity
INE75_RS11765	COG0542	response to heat
INE75_RS11775	COG0237	dephospho-CoA kinase activity
INE75_RS11785	COG1862	Preprotein translocase
INE75_RS11790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INE75_RS11800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INE75_RS11805	COG0193	aminoacyl-tRNA hydrolase activity
INE75_RS11810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INE75_RS11815	COG0673	inositol 2-dehydrogenase activity
INE75_RS11820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE75_RS11820	COG4651	solute:proton antiporter activity
INE75_RS11825	COG0131	Imidazoleglycerol-phosphate dehydratase
INE75_RS11830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE75_RS11835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INE75_RS11840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INE75_RS11880	COG4771	TonB-dependent receptor
INE75_RS11890	COG1595	DNA-templated transcription, initiation
INE75_RS11895	COG2271	Major facilitator Superfamily
INE75_RS11905	COG0702	epimerase
INE75_RS11910	COG1629	transport
INE75_RS11935	COG4232	protein-disulfide reductase activity
INE75_RS11945	COG0572	uridine kinase
INE75_RS11950	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE75_RS11955	COG1410	methionine synthase
INE75_RS11955	COG0646	methionine synthase
INE75_RS11960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INE75_RS12015	COG2003	Belongs to the UPF0758 family
INE75_RS12085	COG0110	maltose O-acetyltransferase activity
INE75_RS12145	COG2217	Heavy metal translocating P-type atpase
INE75_RS12175	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS12180	COG2706	6-phosphogluconolactonase activity
INE75_RS12220	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
INE75_RS12230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INE75_RS12240	COG1253	flavin adenine dinucleotide binding
INE75_RS12270	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
INE75_RS12275	COG0653	protein targeting
INE75_RS12305	COG0561	phosphatase activity
INE75_RS12310	COG4206	TonB-dependent receptor
INE75_RS12310	COG1629	transport
INE75_RS12340	COG0525	valine-tRNA ligase activity
INE75_RS12350	COG3956	TIGRFAM MazG family protein
INE75_RS12365	COG1595	DNA-templated transcription, initiation
INE75_RS12410	COG0492	ferredoxin-NADP+ reductase activity
INE75_RS12420	COG1674	ftsk spoiiie
INE75_RS12455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE75_RS12460	COG2211	Major facilitator Superfamily
INE75_RS12480	COG1136	(ABC) transporter
INE75_RS12490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE75_RS12500	COG4948	Mandelate Racemase Muconate Lactonizing
INE75_RS12535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE75_RS12540	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS12560	COG4948	Mandelate Racemase Muconate Lactonizing
INE75_RS12575	COG1629	transport
INE75_RS12575	COG4206	TonB-dependent receptor
INE75_RS12580	COG1595	DNA-templated transcription, initiation
INE75_RS12595	COG0471	metal ion transport
INE75_RS12595	COG0490	domain, Protein
INE75_RS12610	COG1733	regulation of RNA biosynthetic process
INE75_RS12625	COG1917	Cupin 2, conserved barrel domain protein
INE75_RS12625	COG4977	sequence-specific DNA binding
INE75_RS12640	COG2873	o-acetylhomoserine
INE75_RS12655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INE75_RS12660	COG0523	cobalamin synthesis protein
INE75_RS12665	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE75_RS12670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INE75_RS12680	COG0194	GDP metabolic process
INE75_RS12690	COG1214	PFAM Peptidase M22, glycoprotease
INE75_RS12700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INE75_RS12705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INE75_RS12715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INE75_RS12720	COG0750	zinc metalloprotease
INE75_RS12725	COG0673	inositol 2-dehydrogenase activity
INE75_RS12730	COG0632	four-way junction helicase activity
INE75_RS12740	COG0006	proline dipeptidase activity
INE75_RS12750	COG1082	Xylose isomerase domain protein TIM barrel
INE75_RS12770	COG4771	TonB-dependent receptor
INE75_RS12800	COG1629	transport
INE75_RS12815	COG0363	glucosamine-6-phosphate deaminase activity
INE75_RS12820	COG1940	carbohydrate kinase activity
INE75_RS12825	COG2205	protein histidine kinase activity
INE75_RS12825	COG0745	RESPONSE REGULATOR receiver
INE75_RS12825	COG3292	Two component regulator propeller
INE75_RS12835	COG1408	metallophosphoesterase
INE75_RS12840	COG1575	Belongs to the MenA family. Type 1 subfamily
INE75_RS12850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INE75_RS12860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INE75_RS12870	COG0617	tRNA 3'-terminal CCA addition
INE75_RS12880	COG2204	response regulator
INE75_RS12885	COG0488	(ABC) transporter
INE75_RS12890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE75_RS12925	COG4771	TonB-dependent receptor
INE75_RS12940	COG1595	DNA-templated transcription, initiation
INE75_RS12955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INE75_RS12970	COG1522	sequence-specific DNA binding
INE75_RS13000	COG0811	peptide transport
INE75_RS13010	COG0084	hydrolase, TatD family'
INE75_RS13030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INE75_RS13035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INE75_RS13040	COG0205	6-phosphofructokinase activity
INE75_RS13045	COG1028	Short-chain dehydrogenase reductase Sdr
INE75_RS13060	COG0372	Belongs to the citrate synthase family
INE75_RS13075	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE75_RS13080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INE75_RS13090	COG0440	acetolactate synthase activity
INE75_RS13095	COG0028	Belongs to the TPP enzyme family
INE75_RS13100	COG0129	dihydroxy-acid dehydratase activity
INE75_RS13105	COG1047	Peptidyl-prolyl cis-trans
INE75_RS13110	COG3681	Belongs to the UPF0597 family
INE75_RS13140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE75_RS13140	COG0551	DNA topoisomerase type I activity
INE75_RS13145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE75_RS13145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE75_RS13150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE75_RS13155	COG0569	domain protein
INE75_RS13155	COG2985	domain, Protein
INE75_RS13175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INE75_RS13180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INE75_RS13185	COG0166	Belongs to the GPI family
INE75_RS13190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE75_RS13210	COG0789	Transcriptional regulator
INE75_RS13220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INE75_RS13230	COG2502	aspartate--ammonia ligase
INE75_RS13235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INE75_RS13250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
INE75_RS13260	COG0463	Glycosyl transferase, family 2
INE75_RS13300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
INE75_RS13310	COG0358	DNA primase activity
INE75_RS13340	COG0860	N-Acetylmuramoyl-L-alanine amidase
INE75_RS13350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INE75_RS13355	COG0778	Nitroreductase
INE75_RS13365	COG1640	4-alpha-glucanotransferase
INE75_RS13370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INE75_RS13390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE75_RS13395	COG0318	PFAM AMP-dependent synthetase and ligase
INE75_RS13405	COG0724	RNA recognition motif
INE75_RS13410	COG0359	binds to the 23S rRNA
INE75_RS13415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INE75_RS13420	COG0360	Binds together with S18 to 16S ribosomal RNA
INE75_RS13445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE75_RS13450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
INE75_RS13465	COG2818	Glycosylase
INE75_RS13480	COG1629	transport
INE75_RS13480	COG4206	TonB-dependent receptor
INE75_RS13485	COG3292	Two component regulator propeller
INE75_RS13485	COG0745	RESPONSE REGULATOR receiver
INE75_RS13485	COG2205	protein histidine kinase activity
INE75_RS13505	COG2818	Glycosylase
INE75_RS13510	COG3250	beta-galactosidase activity
INE75_RS13530	COG1082	Xylose isomerase domain protein TIM barrel
INE75_RS13555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INE75_RS13585	COG3279	Response regulator of the LytR AlgR family
INE75_RS13590	COG3275	phosphorelay sensor kinase activity
INE75_RS13595	COG0515	serine threonine protein kinase
INE75_RS13595	COG2815	serine threonine protein kinase
INE75_RS13620	COG0631	protein serine/threonine phosphatase activity
INE75_RS13625	COG2815	serine threonine protein kinase
INE75_RS13625	COG0515	serine threonine protein kinase
INE75_RS13635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE75_RS13640	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
INE75_RS13645	COG1115	amino acid carrier protein
INE75_RS13650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE75_RS13660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INE75_RS13665	COG2333	competence protein COMEC
INE75_RS13665	COG0658	competence protein
INE75_RS13675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INE75_RS13680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INE75_RS13690	COG0009	L-threonylcarbamoyladenylate synthase
INE75_RS13700	COG2207	Transcriptional regulator
INE75_RS13700	COG1609	Transcriptional regulator
INE75_RS13705	COG5183	chlorophyll binding
INE75_RS13705	COG2133	pyrroloquinoline quinone binding
INE75_RS13710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE75_RS13725	COG1785	Belongs to the alkaline phosphatase family
INE75_RS13735	COG3537	Alpha-1,2-mannosidase
INE75_RS13745	COG4206	TonB-dependent receptor
INE75_RS13745	COG1629	transport
INE75_RS13755	COG0823	Involved in the tonB-independent uptake of proteins
INE75_RS13760	COG3022	response to hydroperoxide
INE75_RS13765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INE75_RS13765	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INE75_RS13770	COG0514	ATP-dependent DNA helicase (RecQ)
INE75_RS13790	COG0436	Aminotransferase
INE75_RS13795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
INE75_RS13805	COG0784	Response regulator, receiver
INE75_RS13805	COG2205	protein histidine kinase activity
INE75_RS13810	COG0358	DNA primase activity
INE75_RS13815	COG0302	gtp cyclohydrolase
INE75_RS13825	COG0149	triose-phosphate isomerase activity
INE75_RS13840	COG0739	heme binding
INE75_RS13845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INE75_RS13850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INE75_RS13870	COG0811	peptide transport
INE75_RS13880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INE75_RS13895	COG4771	TonB-dependent receptor
INE75_RS13900	COG0702	epimerase
INE75_RS13905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE75_RS13915	COG3458	cephalosporin-C deacetylase activity
INE75_RS13920	COG4948	Mandelate Racemase Muconate Lactonizing
INE75_RS13925	COG3250	beta-galactosidase activity
INE75_RS13955	COG4771	TonB-dependent receptor
INE75_RS13985	COG0039	L-malate dehydrogenase activity
INE75_RS14020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE75_RS14025	COG0673	inositol 2-dehydrogenase activity
INE75_RS14040	COG0489	protein tyrosine kinase activity
INE75_RS14045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INE75_RS14050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE75_RS14065	COG1570	exodeoxyribonuclease VII activity
INE75_RS14075	COG0482	sulfurtransferase activity
INE75_RS14100	COG0673	inositol 2-dehydrogenase activity
INE75_RS14105	COG1408	metallophosphoesterase
INE75_RS14110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INE75_RS14125	COG4206	TonB-dependent receptor
INE75_RS14125	COG1629	transport
INE75_RS14140	COG0179	Fumarylacetoacetate (FAA) hydrolase
INE75_RS14145	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
INE75_RS14155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INE75_RS14160	COG0052	Belongs to the universal ribosomal protein uS2 family
INE75_RS14165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INE75_RS14170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INE75_RS14180	COG0017	Asparaginyl-tRNA synthetase
INE75_RS14185	COG1187	pseudouridine synthase activity
INE75_RS14205	COG0110	maltose O-acetyltransferase activity
INE75_RS14210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE75_RS14230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INE75_RS14245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE75_RS14255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE75_RS14260	COG0517	IMP dehydrogenase activity
INE75_RS14260	COG0516	GMP reductase activity
INE75_RS14265	COG0514	ATP-dependent DNA helicase (RecQ)
INE75_RS14270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INE75_RS14275	COG0740	serine-type endopeptidase activity
INE75_RS14280	COG0544	peptidyl-prolyl cis-trans isomerase activity
INE75_RS14285	COG0724	RNA recognition motif
INE75_RS14295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
INE75_RS14300	COG1127	ABC transporter
INE75_RS14305	COG1160	GTP binding
INE75_RS14310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INE75_RS14315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE75_RS14360	COG4771	TonB-dependent receptor
INE75_RS14365	COG0702	epimerase
INE75_RS14390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INE75_RS14395	COG2202	Pas domain
INE75_RS14395	COG2205	protein histidine kinase activity
INE75_RS14400	COG2202	Pas domain
INE75_RS14400	COG2205	protein histidine kinase activity
INE75_RS14410	COG0436	Aminotransferase
INE75_RS14415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE75_RS14460	COG4753	response regulator
INE75_RS14460	COG2207	Transcriptional regulator
INE75_RS14465	COG5002	protein histidine kinase activity
INE75_RS14470	COG2205	protein histidine kinase activity
INE75_RS14480	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
INE75_RS14485	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
INE75_RS14490	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
INE75_RS14500	COG2204	response regulator
INE75_RS14505	COG0527	aspartate kinase activity
INE75_RS14505	COG0460	homoserine dehydrogenase
INE75_RS14515	COG2942	2-epimerase
INE75_RS14520	COG2211	Major facilitator Superfamily
INE75_RS14525	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE75_RS14530	COG4124	Belongs to the glycosyl hydrolase 26 family
INE75_RS14590	COG4206	TonB-dependent receptor
INE75_RS14590	COG1629	transport
INE75_RS14600	COG4124	Belongs to the glycosyl hydrolase 26 family
INE75_RS14615	COG0561	phosphatase activity
INE75_RS14620	COG4771	TonB-dependent receptor
INE75_RS14625	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE75_RS14635	COG3458	cephalosporin-C deacetylase activity
INE75_RS14640	COG0662	Cupin 2, conserved barrel domain protein
INE75_RS14640	COG2207	Transcriptional regulator
INE75_RS14645	COG3250	beta-galactosidase activity
INE75_RS14650	COG3459	Glycosyltransferase 36 associated
INE75_RS14655	COG0667	Aldo Keto reductase
INE75_RS14660	COG4948	Mandelate Racemase Muconate Lactonizing
INE75_RS14675	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS14680	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS14685	COG0737	Belongs to the 5'-nucleotidase family
INE75_RS14690	COG0737	Belongs to the 5'-nucleotidase family
INE75_RS14695	COG0335	large ribosomal subunit rRNA binding
INE75_RS14700	COG1940	carbohydrate kinase activity
INE75_RS14705	COG1136	(ABC) transporter
INE75_RS14710	COG0577	efflux transmembrane transporter activity
INE75_RS14710	COG1136	(ABC) transporter
INE75_RS14715	COG0577	efflux transmembrane transporter activity
INE75_RS14715	COG1136	(ABC) transporter
INE75_RS14720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE75_RS14740	COG2996	Protein conserved in bacteria
INE75_RS14745	COG0039	L-malate dehydrogenase activity
INE75_RS14765	COG1454	alcohol dehydrogenase
INE75_RS14770	COG0235	Class ii aldolase
INE75_RS14780	COG4806	L-rhamnose isomerase
INE75_RS14785	COG1070	Carbohydrate kinase
INE75_RS14800	COG0137	argininosuccinate synthase activity
INE75_RS14810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INE75_RS14815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INE75_RS14820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INE75_RS14825	COG1396	sequence-specific DNA binding
INE75_RS14825	COG1917	Cupin 2, conserved barrel domain protein
INE75_RS14830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
INE75_RS14880	COG2433	Pfam Transposase IS66
INE75_RS14940	COG0165	Argininosuccinate lyase
INE75_RS14950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INE75_RS14960	COG2890	protein-(glutamine-N5) methyltransferase activity
INE75_RS14965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE75_RS14965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE75_RS14975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INE75_RS14995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INE75_RS15005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
INE75_RS15010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INE75_RS15040	COG0564	pseudouridine synthase activity
INE75_RS15050	COG0230	Belongs to the bacterial ribosomal protein bL34 family
INE75_RS15055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INE75_RS15060	COG1216	Glycosyl transferase, family 2
INE75_RS15065	COG2003	Belongs to the UPF0758 family
INE75_RS15075	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE75_RS15090	COG1785	Belongs to the alkaline phosphatase family
INE75_RS15095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INE75_RS15100	COG0280	phosphate acetyltransferase
INE75_RS15105	COG1380	Effector of murein hydrolase LrgA
INE75_RS15110	COG1346	cytolysis
INE75_RS15125	COG0312	modulator of DNA gyrase
INE75_RS15130	COG0312	modulator of DNA gyrase
INE75_RS15135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
INE75_RS15140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INE75_RS15145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INE75_RS15155	COG0733	neurotransmitter:sodium symporter activity
INE75_RS15170	COG1136	(ABC) transporter
INE75_RS15175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INE75_RS15180	COG0589	response to stress
INE75_RS15180	COG0475	glutathione-regulated potassium exporter activity
INE75_RS15185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INE75_RS15190	COG0702	epimerase
INE75_RS15195	COG4206	TonB-dependent receptor
INE75_RS15195	COG1629	transport
INE75_RS15205	COG4206	TonB-dependent receptor
INE75_RS15205	COG1629	transport
INE75_RS15210	COG0702	epimerase
INE75_RS15240	COG3876	Protein conserved in bacteria
INE75_RS15245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE75_RS15275	COG2807	transmembrane transport
INE75_RS15280	COG3876	Protein conserved in bacteria
INE75_RS15300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
INE75_RS15305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
INE75_RS15315	COG0423	glycine-tRNA ligase activity
INE75_RS15320	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS15325	COG2382	esterase
INE75_RS15335	COG0702	epimerase
INE75_RS15350	COG4771	TonB-dependent receptor
INE75_RS15365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INE75_RS15370	COG3958	Transketolase
INE75_RS15375	COG3959	Transketolase, thiamine diphosphate binding domain
INE75_RS15380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE75_RS15380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE75_RS15385	COG1349	DNA-binding transcription factor activity
INE75_RS15390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE75_RS15400	COG3250	beta-galactosidase activity
INE75_RS15405	COG0745	RESPONSE REGULATOR receiver
INE75_RS15405	COG2205	protein histidine kinase activity
INE75_RS15405	COG3292	Two component regulator propeller
INE75_RS15415	COG2205	protein histidine kinase activity
INE75_RS15415	COG3292	Two component regulator propeller
INE75_RS15415	COG0745	RESPONSE REGULATOR receiver
INE75_RS15420	COG4771	TonB-dependent receptor
INE75_RS15425	COG0561	phosphatase activity
INE75_RS15440	COG4948	Mandelate Racemase Muconate Lactonizing
INE75_RS15445	COG3250	beta-galactosidase activity
INE75_RS15450	COG1874	Beta-galactosidase
INE75_RS15455	COG3250	beta-galactosidase activity
INE75_RS15465	COG1501	Belongs to the glycosyl hydrolase 31 family
INE75_RS15470	COG3507	Belongs to the glycosyl hydrolase 43 family
INE75_RS15505	COG4771	TonB-dependent receptor
INE75_RS15510	COG0702	epimerase
INE75_RS15515	COG4771	TonB-dependent receptor
INE75_RS15520	COG0702	epimerase
INE75_RS15555	COG2954	triphosphatase activity
INE75_RS15560	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INE75_RS15590	COG4771	TonB-dependent receptor
INE75_RS15595	COG1022	Amp-dependent synthetase and ligase
INE75_RS15605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INE75_RS15610	COG4942	peptidase
INE75_RS15625	COG0756	dUTP diphosphatase activity
INE75_RS15660	COG2001	Belongs to the MraZ family
INE75_RS15675	COG0768	penicillin binding
INE75_RS15680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INE75_RS15685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE75_RS15690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INE75_RS15695	COG0772	Belongs to the SEDS family
INE75_RS15700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INE75_RS15705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INE75_RS15715	COG0849	cell division
INE75_RS15720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INE75_RS15725	COG1610	YqeY-like protein
INE75_RS15730	COG1381	Involved in DNA repair and RecF pathway recombination
INE75_RS15740	COG0268	Binds directly to 16S ribosomal RNA
INE75_RS15745	COG0187	DNA topoisomerase II activity
INE75_RS15755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
INE75_RS15765	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INE75_RS15775	COG1629	transport
INE75_RS15780	COG0702	epimerase
INE75_RS15785	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
INE75_RS15785	COG3408	Glycogen debranching enzyme
INE75_RS15790	COG3250	beta-galactosidase activity
INE75_RS15800	COG2431	L-lysine efflux transmembrane transporter activity
INE75_RS15820	COG3426	butyrate kinase activity
INE75_RS15825	COG0280	phosphate acetyltransferase
INE75_RS15840	COG2166	iron-sulfur cluster assembly
INE75_RS15845	COG3655	Transcriptional regulator
INE75_RS15865	COG1266	CAAX protease self-immunity
INE75_RS15875	COG0196	riboflavin kinase activity
INE75_RS15880	COG1011	Hydrolase
INE75_RS15885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INE75_RS15890	COG0784	Response regulator, receiver
INE75_RS15890	COG2205	protein histidine kinase activity
INE75_RS15895	COG1773	rubredoxin
INE75_RS15900	COG1283	sodium-dependent phosphate transmembrane transporter activity
INE75_RS15910	COG2205	protein histidine kinase activity
INE75_RS15915	COG0006	proline dipeptidase activity
INE75_RS15930	COG0509	glycine decarboxylation via glycine cleavage system
INE75_RS15935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INE75_RS15940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INE75_RS15945	COG2066	Belongs to the glutaminase family
INE75_RS15965	COG3119	arylsulfatase activity
INE75_RS15995	COG0702	epimerase
INE75_RS16000	COG4771	TonB-dependent receptor
INE75_RS16020	COG0793	Belongs to the peptidase S41A family
INE75_RS16025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE75_RS16050	COG0483	inositol monophosphate 1-phosphatase activity
INE75_RS16095	COG1484	DNA-dependent DNA replication
INE75_RS16100	COG4584	PFAM Integrase catalytic
INE75_RS16115	COG2816	NAD+ diphosphatase activity
INE75_RS16135	COG0018	arginyl-trna synthetase
INE75_RS16160	COG0339	signal peptide processing
INE75_RS16165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INE75_RS16170	COG0745	RESPONSE REGULATOR receiver
INE75_RS16170	COG3292	Two component regulator propeller
INE75_RS16170	COG2205	protein histidine kinase activity
INE75_RS16190	COG2211	Major facilitator Superfamily
INE75_RS16205	COG3661	Belongs to the glycosyl hydrolase 67 family
INE75_RS16215	COG3507	Belongs to the glycosyl hydrolase 43 family
INE75_RS16220	COG2382	esterase
INE75_RS16225	COG3507	Belongs to the glycosyl hydrolase 43 family
INE75_RS16230	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
INE75_RS16250	COG1629	transport
INE75_RS16250	COG4206	TonB-dependent receptor
INE75_RS16265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE75_RS16265	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE75_RS16270	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE75_RS16275	COG1629	transport
INE75_RS16275	COG4206	TonB-dependent receptor
INE75_RS16305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INE75_RS16310	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INE75_RS16320	COG1217	gtp-binding protein TYPA
INE75_RS16325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INE75_RS16350	COG0318	PFAM AMP-dependent synthetase and ligase
INE75_RS16355	COG1854	S-ribosylhomocysteine lyase activity
INE75_RS16360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE75_RS16370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INE75_RS16375	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE75_RS16390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
INE75_RS16395	COG4974	Belongs to the 'phage' integrase family
INE75_RS16410	COG0606	chelatase, subunit chli
INE75_RS16420	COG3594	Acyltransferase
INE75_RS16425	COG2972	Histidine kinase
INE75_RS16430	COG3279	Response regulator of the LytR AlgR family
INE75_RS16450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE75_RS16450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE75_RS16465	COG3475	LICD family
INE75_RS16475	COG0438	transferase activity, transferring glycosyl groups
INE75_RS16485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INE75_RS16490	COG0545	Peptidyl-prolyl cis-trans isomerase
INE75_RS16495	COG0545	Peptidyl-prolyl cis-trans isomerase
INE75_RS16500	COG1522	sequence-specific DNA binding
INE75_RS16545	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
INE75_RS16590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INE75_RS16595	COG0793	Belongs to the peptidase S41A family
INE75_RS16595	COG3409	Peptidoglycan-binding domain 1 protein
INE75_RS16600	COG0671	phosphoesterase, PA-phosphatase related
INE75_RS16615	COG1053	succinate dehydrogenase
INE75_RS16620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INE75_RS16660	COG0826	peptidase U32
INE75_RS16665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE75_RS16690	COG0557	exoribonuclease II activity
INE75_RS16700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INE75_RS16705	COG1045	serine acetyltransferase
INE75_RS16710	COG0116	Belongs to the methyltransferase superfamily
INE75_RS16710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE75_RS16715	COG1506	peptidase
INE75_RS16715	COG0823	Involved in the tonB-independent uptake of proteins
INE75_RS16720	COG0151	Belongs to the GarS family
INE75_RS16730	COG1238	metal cluster binding
INE75_RS16745	COG1121	(ABC) transporter
INE75_RS16770	COG4206	TonB-dependent receptor
INE75_RS16770	COG1629	transport
INE75_RS16775	COG1501	Belongs to the glycosyl hydrolase 31 family
INE75_RS16780	COG0745	RESPONSE REGULATOR receiver
INE75_RS16780	COG3292	Two component regulator propeller
INE75_RS16780	COG2205	protein histidine kinase activity
INE75_RS16790	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS16800	COG1785	Belongs to the alkaline phosphatase family
INE75_RS16815	COG1501	Belongs to the glycosyl hydrolase 31 family
INE75_RS17050	COG0551	DNA topoisomerase type I activity
INE75_RS17050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE75_RS17130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INE75_RS17135	COG1120	ATPase activity
INE75_RS17140	COG0784	Response regulator, receiver
INE75_RS17140	COG2198	Histidine kinase
INE75_RS17140	COG2205	protein histidine kinase activity
INE75_RS17145	COG2204	response regulator
INE75_RS17175	COG0582	viral genome integration into host DNA
INE75_RS17185	COG1373	ATPase (AAA superfamily
INE75_RS17205	COG4585	Histidine kinase
INE75_RS17220	COG1028	Short-chain dehydrogenase reductase Sdr
INE75_RS17230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INE75_RS17235	COG0084	hydrolase, TatD family'
INE75_RS17240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INE75_RS17245	COG0594	ribonuclease P activity
INE75_RS17260	COG1611	Belongs to the LOG family
INE75_RS17335	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE75_RS17405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INE75_RS17410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INE75_RS17410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INE75_RS17415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE75_RS17420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INE75_RS17425	COG1968	undecaprenyl-diphosphatase activity
INE75_RS17435	COG2177	Part of the ABC transporter FtsEX involved in
INE75_RS17440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INE75_RS17450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE75_RS17460	COG0427	acetyl-CoA hydrolase
INE75_RS17530	COG3279	Response regulator of the LytR AlgR family
INE75_RS17555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
INE75_RS17570	COG1592	Rubrerythrin
INE75_RS17575	COG0659	secondary active sulfate transmembrane transporter activity
INE75_RS17590	COG0731	radical SAM domain protein
INE75_RS17590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE75_RS17610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE75_RS17615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE75_RS17620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
INE75_RS17625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INE75_RS17630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE75_RS17635	COG0495	leucyl-tRNA aminoacylation
INE75_RS17640	COG0697	spore germination
INE75_RS17665	COG1629	transport
INE75_RS17695	COG0383	alpha-mannosidase activity
INE75_RS17705	COG2205	protein histidine kinase activity
INE75_RS17715	COG0745	RESPONSE REGULATOR receiver
INE75_RS17755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE75_RS17760	COG3250	beta-galactosidase activity
INE75_RS17765	COG0745	RESPONSE REGULATOR receiver
INE75_RS17765	COG2205	protein histidine kinase activity
INE75_RS17765	COG3292	Two component regulator propeller
INE75_RS17770	COG4948	Mandelate Racemase Muconate Lactonizing
INE75_RS17795	COG4206	TonB-dependent receptor
INE75_RS17795	COG1629	transport
INE75_RS17800	COG0702	epimerase
INE75_RS17820	COG3408	Glycogen debranching enzyme
INE75_RS17825	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS17830	COG1501	Belongs to the glycosyl hydrolase 31 family
INE75_RS17835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INE75_RS17850	COG0012	GTP binding
INE75_RS17870	COG1629	transport
INE75_RS17885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE75_RS17885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE75_RS17890	COG0142	geranyltranstransferase activity
INE75_RS17900	COG1694	Mazg nucleotide pyrophosphohydrolase
INE75_RS17905	COG1490	D-aminoacyl-tRNA deacylase activity
INE75_RS17910	COG0322	excinuclease ABC activity
INE75_RS17915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE75_RS17925	COG4206	TonB-dependent receptor
INE75_RS17925	COG1629	transport
INE75_RS17940	COG0745	RESPONSE REGULATOR receiver
INE75_RS17940	COG2205	protein histidine kinase activity
INE75_RS17940	COG3292	Two component regulator propeller
INE75_RS17940	COG0745	RESPONSE REGULATOR receiver
INE75_RS17940	COG3292	Two component regulator propeller
INE75_RS17940	COG2205	protein histidine kinase activity
INE75_RS17945	COG4771	TonB-dependent receptor
INE75_RS17950	COG0702	epimerase
INE75_RS17955	COG3408	Glycogen debranching enzyme
INE75_RS17955	COG3119	arylsulfatase activity
INE75_RS17970	COG2017	converts alpha-aldose to the beta-anomer
INE75_RS17980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INE75_RS17985	COG2715	membrane protein required for spore maturation
INE75_RS17990	COG2234	aminopeptidase activity
INE75_RS18015	COG2255	four-way junction helicase activity
INE75_RS18030	COG3591	Belongs to the peptidase S1B family
INE75_RS18035	COG3634	alkyl hydroperoxide reductase activity
INE75_RS18045	COG0583	DNA-binding transcription factor activity
INE75_RS18050	COG0783	Belongs to the Dps family
INE75_RS18055	COG0513	Belongs to the DEAD box helicase family
INE75_RS18080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE75_RS18090	COG0612	Peptidase, M16
INE75_RS18095	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INE75_RS18110	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE75_RS18115	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS18125	COG1312	Catalyzes the dehydration of D-mannonate
INE75_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
INE75_RS18135	COG3250	beta-galactosidase activity
INE75_RS18140	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE75_RS18145	COG3250	beta-galactosidase activity
INE75_RS18165	COG0561	phosphatase activity
INE75_RS18170	COG4771	TonB-dependent receptor
INE75_RS18175	COG3250	beta-galactosidase activity
INE75_RS18190	COG0681	Belongs to the peptidase S26 family
INE75_RS18200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INE75_RS18225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE75_RS18235	COG5492	domain, Protein
INE75_RS18250	COG4771	TonB-dependent receptor
INE75_RS18255	COG3119	arylsulfatase activity
INE75_RS18260	COG3292	Two component regulator propeller
INE75_RS18260	COG0745	RESPONSE REGULATOR receiver
INE75_RS18260	COG2205	protein histidine kinase activity
INE75_RS18260	COG3292	Two component regulator propeller
INE75_RS18260	COG0745	RESPONSE REGULATOR receiver
INE75_RS18260	COG2205	protein histidine kinase activity
INE75_RS18275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE75_RS18290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE75_RS18310	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE75_RS18315	COG3119	arylsulfatase activity
INE75_RS18330	COG0482	sulfurtransferase activity
INE75_RS18345	COG0205	6-phosphofructokinase activity
INE75_RS18350	COG0571	ribonuclease III activity
INE75_RS18355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INE75_RS18360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INE75_RS18365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INE75_RS18370	COG3083	sulfuric ester hydrolase activity
INE75_RS18375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE75_RS18385	COG0438	transferase activity, transferring glycosyl groups
INE75_RS18390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE75_RS18395	COG4750	Nucleotidyl transferase
INE75_RS18400	COG3475	LICD family
INE75_RS18415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
INE75_RS18415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INE75_RS18425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
INE75_RS18435	COG1368	sulfuric ester hydrolase activity
INE75_RS18445	COG1216	Glycosyl transferase, family 2
INE75_RS18460	COG1216	Glycosyl transferase, family 2
INE75_RS18500	COG1132	(ABC) transporter
INE75_RS18515	COG0673	inositol 2-dehydrogenase activity
INE75_RS18520	COG0673	inositol 2-dehydrogenase activity
INE75_RS18535	COG3341	Caulimovirus viroplasmin
INE75_RS18535	COG0328	RNA-DNA hybrid ribonuclease activity
INE75_RS18545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INE75_RS18550	COG1166	arginine decarboxylase activity
INE75_RS18555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INE75_RS18560	COG1595	DNA-templated transcription, initiation
INE75_RS18610	COG0745	RESPONSE REGULATOR receiver
INE75_RS18610	COG3292	Two component regulator propeller
INE75_RS18610	COG2205	protein histidine kinase activity
INE75_RS18615	COG1629	transport
INE75_RS18620	COG0561	phosphatase activity
INE75_RS18630	COG0745	RESPONSE REGULATOR receiver
INE75_RS18630	COG3292	Two component regulator propeller
INE75_RS18630	COG2205	protein histidine kinase activity
INE75_RS18635	COG2272	Belongs to the type-B carboxylesterase lipase family
INE75_RS18640	COG4206	TonB-dependent receptor
INE75_RS18640	COG1629	transport
INE75_RS18645	COG0702	epimerase
INE75_RS18650	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS18655	COG2382	esterase
INE75_RS18655	COG3507	Belongs to the glycosyl hydrolase 43 family
INE75_RS18655	COG3693	PFAM glycoside hydrolase, family 10
INE75_RS18660	COG2382	esterase
INE75_RS18665	COG2382	esterase
INE75_RS18675	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS18680	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS18685	COG0779	Required for maturation of 30S ribosomal subunits
INE75_RS18690	COG0195	Participates in both transcription termination and antitermination
INE75_RS18695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INE75_RS18705	COG0719	Fe-S assembly protein
INE75_RS18710	COG0396	ATPase activity
INE75_RS18715	COG0719	Fe-S assembly protein
INE75_RS18720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INE75_RS18725	COG0393	Putative heavy-metal-binding
INE75_RS18735	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
INE75_RS18745	COG1629	transport
INE75_RS18745	COG4206	TonB-dependent receptor
INE75_RS18760	COG1185	polyribonucleotide nucleotidyltransferase activity
INE75_RS18770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INE75_RS18775	COG0537	adenosine 5'-monophosphoramidase activity
INE75_RS18780	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
INE75_RS18780	COG0662	Cupin 2, conserved barrel domain protein
INE75_RS18825	COG0358	DNA primase activity
INE75_RS18885	COG0784	Response regulator, receiver
INE75_RS18885	COG2205	protein histidine kinase activity
INE75_RS18895	COG4771	TonB-dependent receptor
INE75_RS18915	COG3507	Belongs to the glycosyl hydrolase 43 family
INE75_RS18920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE75_RS18925	COG3292	Two component regulator propeller
INE75_RS18925	COG2205	protein histidine kinase activity
INE75_RS18925	COG0745	RESPONSE REGULATOR receiver
INE75_RS18930	COG1501	Belongs to the glycosyl hydrolase 31 family
INE75_RS18935	COG3250	beta-galactosidase activity
INE75_RS18940	COG1472	Belongs to the glycosyl hydrolase 3 family
INE75_RS18960	COG2096	Adenosyltransferase
INE75_RS18970	COG0514	ATP-dependent DNA helicase (RecQ)
INE75_RS18975	COG3189	MarR family transcriptional regulator
INE75_RS19070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INE75_RS19075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INE75_RS19125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE75_RS19135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
INE75_RS19140	COG0006	proline dipeptidase activity
INE75_RS19145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
INE75_RS19150	COG4974	Belongs to the 'phage' integrase family
INE75_RS19195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INE75_RS19200	COG0081	regulation of translation
INE75_RS19205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INE75_RS19210	COG0222	ribosome binding
INE75_RS19215	COG0085	RNA polymerase activity
INE75_RS19220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INE75_RS19230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INE75_RS19235	COG0049	tRNA binding
INE75_RS19240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE75_RS19245	COG0051	transcription antitermination factor activity, RNA binding
INE75_RS19250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INE75_RS19255	COG0088	Forms part of the polypeptide exit tunnel
INE75_RS19260	COG0089	rRNA binding
INE75_RS19265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INE75_RS19270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INE75_RS19275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INE75_RS19280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INE75_RS19285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INE75_RS19290	COG0255	Belongs to the universal ribosomal protein uL29 family
INE75_RS19295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INE75_RS19300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INE75_RS19305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INE75_RS19310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INE75_RS19315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INE75_RS19320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INE75_RS19325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INE75_RS19330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INE75_RS19335	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INE75_RS19340	COG1841	ribosomal large subunit assembly
INE75_RS19345	COG0200	Binds to the 23S rRNA
INE75_RS19360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INE75_RS19365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INE75_RS19370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INE75_RS19375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
INE75_RS19380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INE75_RS19385	COG0202	RNA polymerase activity
INE75_RS19390	COG0203	ribosomal protein L17
INE75_RS19405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE75_RS19420	COG2431	L-lysine efflux transmembrane transporter activity
INE75_RS19440	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
INE75_RS19450	COG1228	amidohydrolase
INE75_RS19460	COG2986	histidine ammonia-lyase
INE75_RS19465	COG1309	transcriptional regulator
INE75_RS19475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE75_RS19500	COG1696	Membrane protein involved in D-alanine export
INE75_RS19505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE75_RS19515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE75_RS19610	COG1131	(ABC) transporter
INE75_RS19630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
INE75_RS19655	COG0702	epimerase
INE75_RS19660	COG1629	transport
INE75_RS19665	COG0745	RESPONSE REGULATOR receiver
INE75_RS19665	COG3292	Two component regulator propeller
INE75_RS19665	COG2205	protein histidine kinase activity
INE75_RS19665	COG0745	RESPONSE REGULATOR receiver
INE75_RS19665	COG2205	protein histidine kinase activity
INE75_RS19665	COG3292	Two component regulator propeller
INE75_RS19685	COG0564	pseudouridine synthase activity
INE75_RS19690	COG0823	Involved in the tonB-independent uptake of proteins
INE75_RS19690	COG1506	peptidase
INE75_RS19700	COG2204	response regulator
INE75_RS19705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INE75_RS19710	COG0612	Peptidase, M16
INE75_RS19715	COG0534	Mate efflux family protein
INE75_RS19720	COG0784	Response regulator, receiver
INE75_RS19720	COG2205	protein histidine kinase activity
INE75_RS19740	COG1132	(ABC) transporter
INE75_RS19790	COG2205	protein histidine kinase activity
INE75_RS19790	COG0784	Response regulator, receiver
INE75_RS19795	COG0488	(ABC) transporter
INE75_RS19800	COG3590	peptidase
INE75_RS19805	COG0138	bifunctional purine biosynthesis protein purh
INE75_RS19815	COG1792	Involved in formation and maintenance of cell shape
INE75_RS19830	COG0772	Belongs to the SEDS family
INE75_RS19840	COG1774	PSP1 C-terminal conserved region
INE75_RS19845	COG0470	DNA polymerase III
INE75_RS19850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INE75_RS19865	COG0826	peptidase U32
INE75_RS19880	COG1487	ribonuclease activity
INE75_RS19885	COG4771	TonB-dependent receptor
INE75_RS19900	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
INE75_RS19905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INE75_RS19910	COG0288	reversible hydration of carbon dioxide
INE75_RS19915	COG0252	asparaginase activity
INE75_RS19920	COG0460	homoserine dehydrogenase
INE75_RS19920	COG0527	aspartate kinase activity
INE75_RS19925	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
INE75_RS19930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INE75_RS19980	COG1629	transport
INE75_RS19985	COG0702	epimerase
INE75_RS19990	COG3250	beta-galactosidase activity
INE75_RS20035	COG0456	acetyltransferase
INE75_RS20055	COG0628	permease
INE75_RS20060	COG1435	thymidine kinase activity
INE75_RS20070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE75_RS20085	COG2095	MarC family integral membrane protein
INE75_RS20095	COG4206	TonB-dependent receptor
INE75_RS20095	COG1629	transport
INE75_RS20110	COG1629	transport
INE75_RS20115	COG4974	Belongs to the 'phage' integrase family
INE75_RS20200	COG0776	regulation of translation
INE75_RS20240	COG1196	nuclear chromosome segregation
INE75_RS20240	COG0741	lytic transglycosylase activity
INE75_RS20240	COG0739	heme binding
INE75_RS20245	COG3328	transposase activity
INE75_RS20345	COG4227	nucleotidyltransferase activity
INE75_RS20430	COG0517	IMP dehydrogenase activity
INE75_RS20580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INE75_RS20625	COG1629	transport
INE75_RS20630	COG4206	TonB-dependent receptor
INE75_RS20630	COG1629	transport