locus-tag	class	description
INE84_RS00075	COG1592	Rubrerythrin
INE84_RS00075	COG1773	rubredoxin
INE84_RS00110	COG2264	protein methyltransferase activity
INE84_RS00115	COG3757	hydrolase, family 25
INE84_RS00160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE84_RS00170	COG0363	glucosamine-6-phosphate deaminase activity
INE84_RS00195	COG1032	radical SAM domain protein
INE84_RS00205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INE84_RS00210	COG0463	Glycosyl transferase, family 2
INE84_RS00215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INE84_RS00220	COG0646	methionine synthase
INE84_RS00220	COG1410	methionine synthase
INE84_RS00235	COG1408	metallophosphoesterase
INE84_RS00250	COG0641	radical SAM
INE84_RS00255	COG3591	Belongs to the peptidase S1B family
INE84_RS00260	COG3591	Belongs to the peptidase S1B family
INE84_RS00280	COG0488	(ABC) transporter
INE84_RS00295	COG4771	TonB-dependent receptor
INE84_RS00305	COG0745	RESPONSE REGULATOR receiver
INE84_RS00310	COG5002	protein histidine kinase activity
INE84_RS00315	COG3033	Beta-eliminating lyase
INE84_RS00330	COG0629	single-stranded DNA binding
INE84_RS00340	COG0776	regulation of translation
INE84_RS00345	COG1530	ribonuclease E activity
INE84_RS00350	COG1979	alcohol dehydrogenase
INE84_RS00360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INE84_RS00395	COG4191	Histidine kinase
INE84_RS00400	COG2204	response regulator
INE84_RS00415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE84_RS00425	COG0511	ligase activity, forming carbon-carbon bonds
INE84_RS00430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
INE84_RS00440	COG0366	Alpha amylase catalytic
INE84_RS00445	COG0191	fructose-bisphosphate aldolase activity
INE84_RS00455	COG0254	rRNA binding
INE84_RS00465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
INE84_RS00470	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE84_RS00475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INE84_RS00490	COG1082	Xylose isomerase domain protein TIM barrel
INE84_RS00500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INE84_RS00510	COG0148	phosphopyruvate hydratase activity
INE84_RS00535	COG0702	epimerase
INE84_RS00540	COG1629	transport
INE84_RS00540	COG4206	TonB-dependent receptor
INE84_RS00560	COG0463	Glycosyl transferase, family 2
INE84_RS00575	COG1971	Probably functions as a manganese efflux pump
INE84_RS00580	COG1477	protein flavinylation
INE84_RS00590	COG0037	tRNA processing
INE84_RS00605	COG4864	UPF0365 protein
INE84_RS00625	COG1484	DNA-dependent DNA replication
INE84_RS00630	COG4584	PFAM Integrase catalytic
INE84_RS00670	COG0745	RESPONSE REGULATOR receiver
INE84_RS00675	COG2814	Major facilitator Superfamily
INE84_RS00680	COG1757	Na H antiporter
INE84_RS00720	COG1253	flavin adenine dinucleotide binding
INE84_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
INE84_RS00765	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
INE84_RS00770	COG0542	response to heat
INE84_RS00775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
INE84_RS00795	COG0564	pseudouridine synthase activity
INE84_RS00800	COG1247	-acetyltransferase
INE84_RS00805	COG0346	lactoylglutathione lyase activity
INE84_RS00810	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
INE84_RS00865	COG1388	LysM domain
INE84_RS00865	COG0741	lytic transglycosylase activity
INE84_RS00870	COG1285	pathogenesis
INE84_RS00895	COG1115	amino acid carrier protein
INE84_RS00905	COG1509	lysine 2,3-aminomutase activity
INE84_RS00920	COG0602	queuosine metabolic process
INE84_RS00935	COG0351	phosphomethylpyrimidine kinase
INE84_RS00940	COG2832	Protein of unknown function (DUF454)
INE84_RS00945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE84_RS00975	COG1418	mRNA catabolic process
INE84_RS00980	COG3142	Participates in the control of copper homeostasis
INE84_RS00995	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE84_RS01005	COG0668	transmembrane transport
INE84_RS01010	COG0745	RESPONSE REGULATOR receiver
INE84_RS01030	COG0671	phosphoesterase, PA-phosphatase related
INE84_RS01045	COG1119	ATPase activity
INE84_RS01050	COG1523	belongs to the glycosyl hydrolase 13 family
INE84_RS01055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INE84_RS01075	COG2223	nitrite transmembrane transporter activity
INE84_RS01085	COG1629	transport
INE84_RS01095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INE84_RS01105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INE84_RS01110	COG0126	phosphoglycerate kinase activity
INE84_RS01125	COG0424	maF-like protein
INE84_RS01130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
INE84_RS01145	COG0778	Nitroreductase
INE84_RS01175	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE84_RS01180	COG1629	transport
INE84_RS01180	COG4206	TonB-dependent receptor
INE84_RS01185	COG3250	beta-galactosidase activity
INE84_RS01195	COG1609	Transcriptional regulator
INE84_RS01205	COG1554	hydrolase, family 65, central catalytic
INE84_RS01210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE84_RS01215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE84_RS01230	COG0511	ligase activity, forming carbon-carbon bonds
INE84_RS01245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
INE84_RS01260	COG1280	lysine exporter protein (LysE YggA)
INE84_RS01265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE84_RS01275	COG3292	Two component regulator propeller
INE84_RS01275	COG2205	protein histidine kinase activity
INE84_RS01275	COG0745	RESPONSE REGULATOR receiver
INE84_RS01290	COG1649	PFAM Uncharacterised BCR, COG1649
INE84_RS01295	COG5002	protein histidine kinase activity
INE84_RS01295	COG0784	Response regulator, receiver
INE84_RS01330	COG1966	Carbon starvation protein
INE84_RS01335	COG1649	PFAM Uncharacterised BCR, COG1649
INE84_RS01360	COG2205	protein histidine kinase activity
INE84_RS01360	COG0745	RESPONSE REGULATOR receiver
INE84_RS01360	COG3292	Two component regulator propeller
INE84_RS01375	COG1621	beta-fructofuranosidase activity
INE84_RS01380	COG1621	beta-fructofuranosidase activity
INE84_RS01390	COG1621	beta-fructofuranosidase activity
INE84_RS01395	COG1621	beta-fructofuranosidase activity
INE84_RS01405	COG4771	TonB-dependent receptor
INE84_RS01425	COG2086	electron transfer activity
INE84_RS01430	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INE84_RS01450	COG0484	heat shock protein binding
INE84_RS01470	COG0459	protein refolding
INE84_RS01475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INE84_RS01495	COG0124	histidyl-tRNA synthetase
INE84_RS01515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INE84_RS01520	COG0735	belongs to the Fur family
INE84_RS01540	COG0514	ATP-dependent DNA helicase (RecQ)
INE84_RS01550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INE84_RS01570	COG0066	3-isopropylmalate dehydratase activity
INE84_RS01575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INE84_RS01580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INE84_RS01615	COG0616	signal peptide processing
INE84_RS01620	COG1663	tetraacyldisaccharide 4'-kinase activity
INE84_RS01625	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
INE84_RS01630	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
INE84_RS01800	COG4112	unkown
INE84_RS01825	COG3973	AAA domain
INE84_RS01835	COG0534	Mate efflux family protein
INE84_RS01840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE84_RS01845	COG1597	lipid kinase activity
INE84_RS01850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
INE84_RS01855	COG0612	Peptidase, M16
INE84_RS01870	COG0791	NLP P60 protein
INE84_RS01885	COG3537	Alpha-1,2-mannosidase
INE84_RS01890	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE84_RS01900	COG3537	Alpha-1,2-mannosidase
INE84_RS01925	COG4206	TonB-dependent receptor
INE84_RS01925	COG1629	transport
INE84_RS01930	COG3537	Alpha-1,2-mannosidase
INE84_RS01940	COG1191	sigma factor activity
INE84_RS01955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INE84_RS01960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INE84_RS01965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INE84_RS01970	COG3279	Response regulator of the LytR AlgR family
INE84_RS01985	COG0543	2 iron, 2 sulfur cluster binding
INE84_RS01995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INE84_RS02000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INE84_RS02005	COG0297	glycogen (starch) synthase activity
INE84_RS02020	COG0438	transferase activity, transferring glycosyl groups
INE84_RS02045	COG0519	Catalyzes the synthesis of GMP from XMP
INE84_RS02050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INE84_RS02050	COG0519	Catalyzes the synthesis of GMP from XMP
INE84_RS02055	COG1970	mechanosensitive ion channel activity
INE84_RS02065	COG0339	signal peptide processing
INE84_RS02075	COG2131	deaminase
INE84_RS02080	COG0793	Belongs to the peptidase S41A family
INE84_RS02085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INE84_RS02110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
INE84_RS02125	COG1484	DNA-dependent DNA replication
INE84_RS02130	COG4584	PFAM Integrase catalytic
INE84_RS02195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE84_RS02195	COG2755	lipolytic protein G-D-S-L family
INE84_RS02210	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE84_RS02215	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS02230	COG0702	epimerase
INE84_RS02235	COG4771	TonB-dependent receptor
INE84_RS02245	COG2814	Major facilitator Superfamily
INE84_RS02265	COG2140	Oxalate decarboxylase
INE84_RS02275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE84_RS02285	COG1956	GAF domain-containing protein
INE84_RS02295	COG0101	tRNA pseudouridine synthase activity
INE84_RS02310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
INE84_RS02310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INE84_RS02320	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INE84_RS02325	COG0563	adenylate kinase activity
INE84_RS02330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE84_RS02335	COG1496	oxidoreductase activity
INE84_RS02350	COG1702	phosphate starvation-inducible protein PhoH
INE84_RS02355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INE84_RS02360	COG2226	methyltransferase
INE84_RS02370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INE84_RS02385	COG1704	LemA family
INE84_RS02390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INE84_RS02395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INE84_RS02400	COG0284	orotidine-5'-phosphate decarboxylase activity
INE84_RS02405	COG1078	dGTPase activity
INE84_RS02410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE84_RS02415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INE84_RS02415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
INE84_RS02420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE84_RS02430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE84_RS02445	COG4206	TonB-dependent receptor
INE84_RS02445	COG1629	transport
INE84_RS02470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE84_RS02470	COG1333	cytochrome c biogenesis protein
INE84_RS02495	COG3487	Iron-regulated protein
INE84_RS02510	COG1073	alpha beta
INE84_RS02520	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS02535	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE84_RS02550	COG0561	phosphatase activity
INE84_RS02555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE84_RS02560	COG0009	L-threonylcarbamoyladenylate synthase
INE84_RS02565	COG0628	permease
INE84_RS02655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE84_RS02675	COG0681	Belongs to the peptidase S26 family
INE84_RS02715	COG0363	glucosamine-6-phosphate deaminase activity
INE84_RS02725	COG1242	4 iron, 4 sulfur cluster binding
INE84_RS02735	COG2814	Major facilitator Superfamily
INE84_RS02740	COG4821	SIS domain
INE84_RS02745	COG0823	Involved in the tonB-independent uptake of proteins
INE84_RS02745	COG1506	peptidase
INE84_RS02750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INE84_RS02760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE84_RS02765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
INE84_RS02770	COG0546	phosphoglycolate phosphatase activity
INE84_RS02785	COG4771	TonB-dependent receptor
INE84_RS02800	COG3775	system Galactitol-specific IIC component
INE84_RS02805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
INE84_RS02820	COG0805	protein transport
INE84_RS02825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INE84_RS02830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INE84_RS02845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INE84_RS02850	COG0569	domain protein
INE84_RS02855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE84_RS02865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE84_RS02870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE84_RS02875	COG0649	NAD binding
INE84_RS02875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE84_RS02880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INE84_RS02885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE84_RS02890	COG0839	Belongs to the complex I subunit 6 family
INE84_RS02895	COG0713	ATP synthesis coupled electron transport
INE84_RS02900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INE84_RS02905	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE84_RS02915	COG0784	Response regulator, receiver
INE84_RS02915	COG2205	protein histidine kinase activity
INE84_RS02915	COG5002	protein histidine kinase activity
INE84_RS02920	COG1404	Belongs to the peptidase S8 family
INE84_RS02920	COG4412	M6 family metalloprotease domain protein
INE84_RS02935	COG0668	transmembrane transport
INE84_RS02945	COG1119	ATPase activity
INE84_RS02975	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE84_RS02985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INE84_RS02990	COG2239	Acts as a magnesium transporter
INE84_RS02995	COG1196	nuclear chromosome segregation
INE84_RS03000	COG0138	bifunctional purine biosynthesis protein purh
INE84_RS03015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INE84_RS03030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE84_RS03035	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
INE84_RS03050	COG1192	Involved in chromosome partitioning
INE84_RS03055	COG1475	DNA binding
INE84_RS03065	COG1388	LysM domain
INE84_RS03065	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE84_RS03080	COG0739	heme binding
INE84_RS03110	COG0742	ribosomal rna small subunit methyltransferase
INE84_RS03115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INE84_RS03130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INE84_RS03135	COG2315	Protein conserved in bacteria
INE84_RS03155	COG1484	DNA-dependent DNA replication
INE84_RS03160	COG4584	PFAM Integrase catalytic
INE84_RS03200	COG0561	phosphatase activity
INE84_RS03205	COG4771	TonB-dependent receptor
INE84_RS03255	COG0823	Involved in the tonB-independent uptake of proteins
INE84_RS03255	COG1506	peptidase
INE84_RS03255	COG4946	Tricorn protease homolog
INE84_RS03260	COG0490	domain, Protein
INE84_RS03260	COG2985	domain, Protein
INE84_RS03270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE84_RS03280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INE84_RS03290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INE84_RS03320	COG0688	phosphatidylethanolamine metabolic process
INE84_RS03325	COG1183	phosphatidylcholine synthase activity
INE84_RS03350	COG0792	nuclease activity
INE84_RS03365	COG3250	beta-galactosidase activity
INE84_RS03375	COG0702	epimerase
INE84_RS03380	COG4771	TonB-dependent receptor
INE84_RS03400	COG0534	Mate efflux family protein
INE84_RS03405	COG2217	Heavy metal translocating P-type atpase
INE84_RS03410	COG0697	spore germination
INE84_RS03420	COG0528	UMP kinase activity
INE84_RS03425	COG0233	cytoplasmic translational termination
INE84_RS03430	COG1162	GTPase activity
INE84_RS03435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE84_RS03440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE84_RS03450	COG0531	amino acid
INE84_RS03460	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INE84_RS03460	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INE84_RS03470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INE84_RS03485	COG1629	transport
INE84_RS03485	COG4206	TonB-dependent receptor
INE84_RS03495	COG1629	transport
INE84_RS03510	COG1373	ATPase (AAA superfamily
INE84_RS03520	COG1629	transport
INE84_RS03520	COG4206	TonB-dependent receptor
INE84_RS03525	COG4771	TonB-dependent receptor
INE84_RS03540	COG1373	ATPase (AAA superfamily
INE84_RS03545	COG1629	transport
INE84_RS03545	COG4206	TonB-dependent receptor
INE84_RS03555	COG2095	MarC family integral membrane protein
INE84_RS03570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE84_RS03580	COG1435	thymidine kinase activity
INE84_RS03585	COG0628	permease
INE84_RS03615	COG1309	transcriptional regulator
INE84_RS03665	COG0326	Molecular chaperone. Has ATPase activity
INE84_RS03695	COG0456	acetyltransferase
INE84_RS03765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INE84_RS03770	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
INE84_RS03775	COG0460	homoserine dehydrogenase
INE84_RS03775	COG0527	aspartate kinase activity
INE84_RS03780	COG0252	asparaginase activity
INE84_RS03785	COG0288	reversible hydration of carbon dioxide
INE84_RS03790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INE84_RS03795	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
INE84_RS03800	COG3292	Two component regulator propeller
INE84_RS03800	COG2205	protein histidine kinase activity
INE84_RS03800	COG0745	RESPONSE REGULATOR receiver
INE84_RS03800	COG0745	RESPONSE REGULATOR receiver
INE84_RS03800	COG2205	protein histidine kinase activity
INE84_RS03800	COG3292	Two component regulator propeller
INE84_RS03810	COG4771	TonB-dependent receptor
INE84_RS03815	COG1487	ribonuclease activity
INE84_RS03830	COG0826	peptidase U32
INE84_RS03845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INE84_RS03850	COG0470	DNA polymerase III
INE84_RS03855	COG1774	PSP1 C-terminal conserved region
INE84_RS03875	COG0772	Belongs to the SEDS family
INE84_RS03890	COG1792	Involved in formation and maintenance of cell shape
INE84_RS03900	COG0138	bifunctional purine biosynthesis protein purh
INE84_RS03905	COG3590	peptidase
INE84_RS03910	COG0488	(ABC) transporter
INE84_RS03915	COG2205	protein histidine kinase activity
INE84_RS03915	COG0784	Response regulator, receiver
INE84_RS03990	COG2205	protein histidine kinase activity
INE84_RS03990	COG0784	Response regulator, receiver
INE84_RS03995	COG0534	Mate efflux family protein
INE84_RS04000	COG0612	Peptidase, M16
INE84_RS04005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INE84_RS04010	COG2204	response regulator
INE84_RS04020	COG1506	peptidase
INE84_RS04020	COG0823	Involved in the tonB-independent uptake of proteins
INE84_RS04025	COG0564	pseudouridine synthase activity
INE84_RS04045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
INE84_RS04065	COG1131	(ABC) transporter
INE84_RS04155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE84_RS04165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE84_RS04170	COG1696	Membrane protein involved in D-alanine export
INE84_RS04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE84_RS04205	COG1309	transcriptional regulator
INE84_RS04210	COG2986	histidine ammonia-lyase
INE84_RS04220	COG1228	amidohydrolase
INE84_RS04230	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
INE84_RS04250	COG2431	L-lysine efflux transmembrane transporter activity
INE84_RS04265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE84_RS04280	COG0203	ribosomal protein L17
INE84_RS04285	COG0202	RNA polymerase activity
INE84_RS04290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INE84_RS04295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
INE84_RS04300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INE84_RS04305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INE84_RS04310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INE84_RS04325	COG0200	Binds to the 23S rRNA
INE84_RS04330	COG1841	ribosomal large subunit assembly
INE84_RS04335	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INE84_RS04340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INE84_RS04345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INE84_RS04350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INE84_RS04355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INE84_RS04360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INE84_RS04365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INE84_RS04370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INE84_RS04375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INE84_RS04380	COG0255	Belongs to the universal ribosomal protein uL29 family
INE84_RS04385	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INE84_RS04390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INE84_RS04395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INE84_RS04400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INE84_RS04405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INE84_RS04410	COG0089	rRNA binding
INE84_RS04415	COG0088	Forms part of the polypeptide exit tunnel
INE84_RS04420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INE84_RS04425	COG0051	transcription antitermination factor activity, RNA binding
INE84_RS04430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE84_RS04435	COG0049	tRNA binding
INE84_RS04440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INE84_RS04450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INE84_RS04455	COG0085	RNA polymerase activity
INE84_RS04460	COG0222	ribosome binding
INE84_RS04465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INE84_RS04470	COG0081	regulation of translation
INE84_RS04475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INE84_RS04520	COG4974	Belongs to the 'phage' integrase family
INE84_RS04525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
INE84_RS04530	COG0006	proline dipeptidase activity
INE84_RS04535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
INE84_RS04545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE84_RS04605	COG3550	peptidyl-serine autophosphorylation
INE84_RS04640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INE84_RS04645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INE84_RS04660	COG4974	Belongs to the 'phage' integrase family
INE84_RS04665	COG4974	Belongs to the 'phage' integrase family
INE84_RS04690	COG0010	Belongs to the arginase family
INE84_RS04695	COG0058	SHG alpha-glucan phosphorylase activity
INE84_RS04700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE84_RS04700	COG4651	solute:proton antiporter activity
INE84_RS04705	COG0205	6-phosphofructokinase activity
INE84_RS04720	COG0588	phosphoglycerate mutase activity
INE84_RS04725	COG1830	Aldolase
INE84_RS04735	COG2095	MarC family integral membrane protein
INE84_RS04765	COG1477	protein flavinylation
INE84_RS04860	COG3189	MarR family transcriptional regulator
INE84_RS04865	COG0514	ATP-dependent DNA helicase (RecQ)
INE84_RS04875	COG2096	Adenosyltransferase
INE84_RS04895	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS04900	COG3250	beta-galactosidase activity
INE84_RS04905	COG1501	Belongs to the glycosyl hydrolase 31 family
INE84_RS04910	COG3292	Two component regulator propeller
INE84_RS04910	COG2205	protein histidine kinase activity
INE84_RS04910	COG0745	RESPONSE REGULATOR receiver
INE84_RS04915	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE84_RS04920	COG3507	Belongs to the glycosyl hydrolase 43 family
INE84_RS04940	COG4771	TonB-dependent receptor
INE84_RS04950	COG2205	protein histidine kinase activity
INE84_RS04950	COG0784	Response regulator, receiver
INE84_RS04965	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
INE84_RS04965	COG0662	Cupin 2, conserved barrel domain protein
INE84_RS04970	COG0537	adenosine 5'-monophosphoramidase activity
INE84_RS04975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INE84_RS04985	COG1185	polyribonucleotide nucleotidyltransferase activity
INE84_RS05000	COG4206	TonB-dependent receptor
INE84_RS05000	COG1629	transport
INE84_RS05010	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
INE84_RS05020	COG0393	Putative heavy-metal-binding
INE84_RS05025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INE84_RS05030	COG0719	Fe-S assembly protein
INE84_RS05035	COG0396	ATPase activity
INE84_RS05040	COG0719	Fe-S assembly protein
INE84_RS05050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INE84_RS05055	COG0195	Participates in both transcription termination and antitermination
INE84_RS05060	COG0779	Required for maturation of 30S ribosomal subunits
INE84_RS05065	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS05070	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS05075	COG2382	esterase
INE84_RS05080	COG2382	esterase
INE84_RS05085	COG2382	esterase
INE84_RS05085	COG3507	Belongs to the glycosyl hydrolase 43 family
INE84_RS05085	COG3693	PFAM glycoside hydrolase, family 10
INE84_RS05090	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS05095	COG0702	epimerase
INE84_RS05100	COG4206	TonB-dependent receptor
INE84_RS05100	COG1629	transport
INE84_RS05105	COG2272	Belongs to the type-B carboxylesterase lipase family
INE84_RS05110	COG3292	Two component regulator propeller
INE84_RS05110	COG0745	RESPONSE REGULATOR receiver
INE84_RS05110	COG2205	protein histidine kinase activity
INE84_RS05150	COG1595	DNA-templated transcription, initiation
INE84_RS05155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INE84_RS05160	COG1166	arginine decarboxylase activity
INE84_RS05165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INE84_RS05175	COG0328	RNA-DNA hybrid ribonuclease activity
INE84_RS05175	COG3341	Caulimovirus viroplasmin
INE84_RS05190	COG0673	inositol 2-dehydrogenase activity
INE84_RS05195	COG0673	inositol 2-dehydrogenase activity
INE84_RS05200	COG1132	(ABC) transporter
INE84_RS05230	COG1216	Glycosyl transferase, family 2
INE84_RS05230	COG1442	glycosyl transferase family 8
INE84_RS05255	COG3754	Rhamnan synthesis protein F
INE84_RS05260	COG1442	glycosyl transferase family 8
INE84_RS05260	COG1216	Glycosyl transferase, family 2
INE84_RS05270	COG1368	sulfuric ester hydrolase activity
INE84_RS05280	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
INE84_RS05285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
INE84_RS05290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
INE84_RS05290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INE84_RS05305	COG3475	LICD family
INE84_RS05310	COG4750	Nucleotidyl transferase
INE84_RS05315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE84_RS05320	COG0438	transferase activity, transferring glycosyl groups
INE84_RS05330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE84_RS05335	COG3083	sulfuric ester hydrolase activity
INE84_RS05340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INE84_RS05345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INE84_RS05350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INE84_RS05355	COG0571	ribonuclease III activity
INE84_RS05360	COG0205	6-phosphofructokinase activity
INE84_RS05375	COG0482	sulfurtransferase activity
INE84_RS05390	COG3119	arylsulfatase activity
INE84_RS05395	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE84_RS05415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE84_RS05430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE84_RS05445	COG3292	Two component regulator propeller
INE84_RS05445	COG2205	protein histidine kinase activity
INE84_RS05445	COG0745	RESPONSE REGULATOR receiver
INE84_RS05445	COG3292	Two component regulator propeller
INE84_RS05445	COG2205	protein histidine kinase activity
INE84_RS05445	COG0745	RESPONSE REGULATOR receiver
INE84_RS05450	COG3119	arylsulfatase activity
INE84_RS05455	COG4771	TonB-dependent receptor
INE84_RS05470	COG5492	domain, Protein
INE84_RS05480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE84_RS05505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INE84_RS05515	COG0681	Belongs to the peptidase S26 family
INE84_RS05530	COG1028	Short-chain dehydrogenase reductase Sdr
INE84_RS05535	COG1312	Catalyzes the dehydration of D-mannonate
INE84_RS05540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INE84_RS05545	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS05550	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE84_RS05565	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INE84_RS05570	COG0612	Peptidase, M16
INE84_RS05580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE84_RS05605	COG0513	Belongs to the DEAD box helicase family
INE84_RS05610	COG0783	Belongs to the Dps family
INE84_RS05615	COG0583	DNA-binding transcription factor activity
INE84_RS05625	COG3634	alkyl hydroperoxide reductase activity
INE84_RS05630	COG3591	Belongs to the peptidase S1B family
INE84_RS05640	COG3645	SOS response
INE84_RS05650	COG2255	four-way junction helicase activity
INE84_RS05660	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE84_RS05665	COG4206	TonB-dependent receptor
INE84_RS05665	COG1629	transport
INE84_RS05675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE84_RS05680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE84_RS05695	COG2234	aminopeptidase activity
INE84_RS05700	COG2715	membrane protein required for spore maturation
INE84_RS05705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INE84_RS05715	COG2017	converts alpha-aldose to the beta-anomer
INE84_RS05725	COG3408	Glycogen debranching enzyme
INE84_RS05755	COG4771	TonB-dependent receptor
INE84_RS05760	COG0745	RESPONSE REGULATOR receiver
INE84_RS05760	COG3292	Two component regulator propeller
INE84_RS05760	COG0745	RESPONSE REGULATOR receiver
INE84_RS05760	COG2205	protein histidine kinase activity
INE84_RS05760	COG3292	Two component regulator propeller
INE84_RS05760	COG2205	protein histidine kinase activity
INE84_RS05775	COG1629	transport
INE84_RS05775	COG4206	TonB-dependent receptor
INE84_RS05785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE84_RS05790	COG0322	excinuclease ABC activity
INE84_RS05795	COG1490	D-aminoacyl-tRNA deacylase activity
INE84_RS05800	COG1694	Mazg nucleotide pyrophosphohydrolase
INE84_RS05810	COG0142	geranyltranstransferase activity
INE84_RS05815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE84_RS05815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE84_RS05835	COG0012	GTP binding
INE84_RS05850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INE84_RS05855	COG1501	Belongs to the glycosyl hydrolase 31 family
INE84_RS05860	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS05865	COG3408	Glycogen debranching enzyme
INE84_RS05885	COG0702	epimerase
INE84_RS05890	COG4206	TonB-dependent receptor
INE84_RS05890	COG1629	transport
INE84_RS05915	COG4948	Mandelate Racemase Muconate Lactonizing
INE84_RS05920	COG0745	RESPONSE REGULATOR receiver
INE84_RS05920	COG3292	Two component regulator propeller
INE84_RS05920	COG2205	protein histidine kinase activity
INE84_RS05925	COG3250	beta-galactosidase activity
INE84_RS05930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE84_RS05935	COG4584	PFAM Integrase catalytic
INE84_RS05940	COG1484	DNA-dependent DNA replication
INE84_RS05945	COG4948	Mandelate Racemase Muconate Lactonizing
INE84_RS05975	COG4771	TonB-dependent receptor
INE84_RS05990	COG0738	Major facilitator superfamily
INE84_RS06005	COG1609	Transcriptional regulator
INE84_RS06025	COG1629	transport
INE84_RS06025	COG4206	TonB-dependent receptor
INE84_RS06035	COG4948	Mandelate Racemase Muconate Lactonizing
INE84_RS06045	COG0697	spore germination
INE84_RS06050	COG0495	leucyl-tRNA aminoacylation
INE84_RS06055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE84_RS06060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INE84_RS06065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
INE84_RS06070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE84_RS06075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE84_RS06095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE84_RS06095	COG0731	radical SAM domain protein
INE84_RS06110	COG0659	secondary active sulfate transmembrane transporter activity
INE84_RS06115	COG1592	Rubrerythrin
INE84_RS06150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
INE84_RS06240	COG0427	acetyl-CoA hydrolase
INE84_RS06250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE84_RS06265	COG2177	Part of the ABC transporter FtsEX involved in
INE84_RS06275	COG1968	undecaprenyl-diphosphatase activity
INE84_RS06280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INE84_RS06285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE84_RS06290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INE84_RS06290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INE84_RS06295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INE84_RS06300	COG0784	Response regulator, receiver
INE84_RS06300	COG2205	protein histidine kinase activity
INE84_RS06330	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE84_RS06400	COG1611	Belongs to the LOG family
INE84_RS06415	COG0594	ribonuclease P activity
INE84_RS06420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INE84_RS06425	COG0084	hydrolase, TatD family'
INE84_RS06430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INE84_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
INE84_RS06455	COG4585	Histidine kinase
INE84_RS06505	COG3291	Pkd domain containing protein
INE84_RS06510	COG0745	RESPONSE REGULATOR receiver
INE84_RS06510	COG2205	protein histidine kinase activity
INE84_RS06510	COG3292	Two component regulator propeller
INE84_RS06515	COG1501	Belongs to the glycosyl hydrolase 31 family
INE84_RS06520	COG1629	transport
INE84_RS06520	COG4206	TonB-dependent receptor
INE84_RS06530	COG2942	2-epimerase
INE84_RS06560	COG1238	metal cluster binding
INE84_RS06570	COG0151	Belongs to the GarS family
INE84_RS06575	COG0823	Involved in the tonB-independent uptake of proteins
INE84_RS06575	COG1506	peptidase
INE84_RS06580	COG0116	Belongs to the methyltransferase superfamily
INE84_RS06580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE84_RS06585	COG1045	serine acetyltransferase
INE84_RS06590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INE84_RS06600	COG0557	exoribonuclease II activity
INE84_RS06620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE84_RS06625	COG0826	peptidase U32
INE84_RS06635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INE84_RS06635	COG0758	DNA mediated transformation
INE84_RS06665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INE84_RS06670	COG1053	succinate dehydrogenase
INE84_RS06685	COG0671	phosphoesterase, PA-phosphatase related
INE84_RS06690	COG3409	Peptidoglycan-binding domain 1 protein
INE84_RS06690	COG0793	Belongs to the peptidase S41A family
INE84_RS06695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INE84_RS06740	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
INE84_RS06765	COG3279	Response regulator of the LytR AlgR family
INE84_RS06815	COG1522	sequence-specific DNA binding
INE84_RS06820	COG0545	Peptidyl-prolyl cis-trans isomerase
INE84_RS06825	COG0545	Peptidyl-prolyl cis-trans isomerase
INE84_RS06830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INE84_RS06840	COG0438	transferase activity, transferring glycosyl groups
INE84_RS06850	COG3475	LICD family
INE84_RS06870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE84_RS06870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE84_RS06905	COG2972	Histidine kinase
INE84_RS06910	COG3594	Acyltransferase
INE84_RS06920	COG2205	protein histidine kinase activity
INE84_RS06920	COG0745	RESPONSE REGULATOR receiver
INE84_RS06920	COG3292	Two component regulator propeller
INE84_RS06935	COG4975	Glucose uptake
INE84_RS06940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE84_RS06950	COG1629	transport
INE84_RS06960	COG3537	Alpha-1,2-mannosidase
INE84_RS06970	COG0366	Alpha amylase catalytic
INE84_RS06975	COG0606	chelatase, subunit chli
INE84_RS06990	COG4974	Belongs to the 'phage' integrase family
INE84_RS06995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
INE84_RS07010	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE84_RS07015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INE84_RS07025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE84_RS07030	COG1854	S-ribosylhomocysteine lyase activity
INE84_RS07035	COG0318	PFAM AMP-dependent synthetase and ligase
INE84_RS07060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INE84_RS07065	COG1217	gtp-binding protein TYPA
INE84_RS07075	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INE84_RS07080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INE84_RS07110	COG4206	TonB-dependent receptor
INE84_RS07110	COG1629	transport
INE84_RS07115	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE84_RS07120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE84_RS07120	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE84_RS07135	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS07145	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS07150	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS07165	COG4771	TonB-dependent receptor
INE84_RS07175	COG4977	sequence-specific DNA binding
INE84_RS07175	COG1917	Cupin 2, conserved barrel domain protein
INE84_RS07180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE84_RS07185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE84_RS07205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INE84_RS07210	COG0339	signal peptide processing
INE84_RS07235	COG0018	arginyl-trna synthetase
INE84_RS07255	COG2816	NAD+ diphosphatase activity
INE84_RS07290	COG0483	inositol monophosphate 1-phosphatase activity
INE84_RS07315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE84_RS07320	COG0793	Belongs to the peptidase S41A family
INE84_RS07335	COG4584	PFAM Integrase catalytic
INE84_RS07340	COG1484	DNA-dependent DNA replication
INE84_RS07355	COG3250	beta-galactosidase activity
INE84_RS07360	COG3119	arylsulfatase activity
INE84_RS07370	COG3119	arylsulfatase activity
INE84_RS07375	COG3119	arylsulfatase activity
INE84_RS07385	COG4771	TonB-dependent receptor
INE84_RS07390	COG0702	epimerase
INE84_RS07410	COG3119	arylsulfatase activity
INE84_RS07425	COG3119	arylsulfatase activity
INE84_RS07440	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INE84_RS07445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INE84_RS07450	COG0509	glycine decarboxylation via glycine cleavage system
INE84_RS07465	COG0006	proline dipeptidase activity
INE84_RS07470	COG2205	protein histidine kinase activity
INE84_RS07475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INE84_RS07480	COG1283	sodium-dependent phosphate transmembrane transporter activity
INE84_RS07485	COG1773	rubredoxin
INE84_RS07490	COG0784	Response regulator, receiver
INE84_RS07490	COG2205	protein histidine kinase activity
INE84_RS07495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INE84_RS07500	COG1011	Hydrolase
INE84_RS07505	COG0196	riboflavin kinase activity
INE84_RS07515	COG1266	CAAX protease self-immunity
INE84_RS07545	COG3655	Transcriptional regulator
INE84_RS07560	COG2166	iron-sulfur cluster assembly
INE84_RS07575	COG0280	phosphate acetyltransferase
INE84_RS07580	COG3426	butyrate kinase activity
INE84_RS07585	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
INE84_RS07585	COG3408	Glycogen debranching enzyme
INE84_RS07595	COG2431	L-lysine efflux transmembrane transporter activity
INE84_RS07605	COG3250	beta-galactosidase activity
INE84_RS07610	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
INE84_RS07610	COG3408	Glycogen debranching enzyme
INE84_RS07615	COG0702	epimerase
INE84_RS07620	COG1629	transport
INE84_RS07630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INE84_RS07650	COG2942	2-epimerase
INE84_RS07655	COG4771	TonB-dependent receptor
INE84_RS07660	COG0702	epimerase
INE84_RS07670	COG4124	Belongs to the glycosyl hydrolase 26 family
INE84_RS07675	COG3250	beta-galactosidase activity
INE84_RS07690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
INE84_RS07700	COG0187	DNA topoisomerase II activity
INE84_RS07705	COG0268	Binds directly to 16S ribosomal RNA
INE84_RS07715	COG1381	Involved in DNA repair and RecF pathway recombination
INE84_RS07720	COG1610	YqeY-like protein
INE84_RS07725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INE84_RS07730	COG0849	cell division
INE84_RS07740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INE84_RS07745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INE84_RS07750	COG0772	Belongs to the SEDS family
INE84_RS07755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INE84_RS07760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE84_RS07765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INE84_RS07770	COG0768	penicillin binding
INE84_RS07785	COG2001	Belongs to the MraZ family
INE84_RS07820	COG0756	dUTP diphosphatase activity
INE84_RS07835	COG4942	peptidase
INE84_RS07840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INE84_RS07850	COG1022	Amp-dependent synthetase and ligase
INE84_RS07855	COG4771	TonB-dependent receptor
INE84_RS07890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INE84_RS07895	COG2954	triphosphatase activity
INE84_RS07925	COG0702	epimerase
INE84_RS07930	COG4771	TonB-dependent receptor
INE84_RS07955	COG4206	TonB-dependent receptor
INE84_RS07955	COG1629	transport
INE84_RS07990	COG3507	Belongs to the glycosyl hydrolase 43 family
INE84_RS07995	COG1501	Belongs to the glycosyl hydrolase 31 family
INE84_RS08005	COG3250	beta-galactosidase activity
INE84_RS08010	COG1874	Beta-galactosidase
INE84_RS08015	COG3250	beta-galactosidase activity
INE84_RS08020	COG4948	Mandelate Racemase Muconate Lactonizing
INE84_RS08035	COG0561	phosphatase activity
INE84_RS08040	COG4771	TonB-dependent receptor
INE84_RS08045	COG3292	Two component regulator propeller
INE84_RS08045	COG2205	protein histidine kinase activity
INE84_RS08045	COG0745	RESPONSE REGULATOR receiver
INE84_RS08050	COG3250	beta-galactosidase activity
INE84_RS08060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE84_RS08065	COG1349	DNA-binding transcription factor activity
INE84_RS08070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE84_RS08070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE84_RS08075	COG3959	Transketolase, thiamine diphosphate binding domain
INE84_RS08080	COG3958	Transketolase
INE84_RS08085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INE84_RS08100	COG4771	TonB-dependent receptor
INE84_RS08105	COG0702	epimerase
INE84_RS08115	COG2382	esterase
INE84_RS08120	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS08125	COG0423	glycine-tRNA ligase activity
INE84_RS08135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
INE84_RS08140	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
INE84_RS08160	COG3876	Protein conserved in bacteria
INE84_RS08165	COG2807	transmembrane transport
INE84_RS08195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE84_RS08200	COG3876	Protein conserved in bacteria
INE84_RS08230	COG0702	epimerase
INE84_RS08235	COG1629	transport
INE84_RS08235	COG4206	TonB-dependent receptor
INE84_RS08245	COG1629	transport
INE84_RS08245	COG4206	TonB-dependent receptor
INE84_RS08260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INE84_RS08265	COG0589	response to stress
INE84_RS08265	COG0475	glutathione-regulated potassium exporter activity
INE84_RS08270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INE84_RS08275	COG1136	(ABC) transporter
INE84_RS08290	COG0733	neurotransmitter:sodium symporter activity
INE84_RS08300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INE84_RS08305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INE84_RS08310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
INE84_RS08315	COG0312	modulator of DNA gyrase
INE84_RS08320	COG0312	modulator of DNA gyrase
INE84_RS08335	COG1346	cytolysis
INE84_RS08340	COG1380	Effector of murein hydrolase LrgA
INE84_RS08345	COG0280	phosphate acetyltransferase
INE84_RS08350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INE84_RS08355	COG1785	Belongs to the alkaline phosphatase family
INE84_RS08370	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE84_RS08390	COG2003	Belongs to the UPF0758 family
INE84_RS08395	COG1216	Glycosyl transferase, family 2
INE84_RS08400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INE84_RS08405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
INE84_RS08415	COG0564	pseudouridine synthase activity
INE84_RS08445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INE84_RS08450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
INE84_RS08460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INE84_RS08480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INE84_RS08490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE84_RS08490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE84_RS08495	COG2890	protein-(glutamine-N5) methyltransferase activity
INE84_RS08505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INE84_RS08515	COG0165	Argininosuccinate lyase
INE84_RS08535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
INE84_RS08540	COG1917	Cupin 2, conserved barrel domain protein
INE84_RS08540	COG1396	sequence-specific DNA binding
INE84_RS08545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INE84_RS08550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INE84_RS08555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INE84_RS08565	COG0137	argininosuccinate synthase activity
INE84_RS08580	COG1070	Carbohydrate kinase
INE84_RS08585	COG4806	L-rhamnose isomerase
INE84_RS08595	COG0235	Class ii aldolase
INE84_RS08600	COG1454	alcohol dehydrogenase
INE84_RS08620	COG0039	L-malate dehydrogenase activity
INE84_RS08625	COG2996	Protein conserved in bacteria
INE84_RS08645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE84_RS08650	COG0577	efflux transmembrane transporter activity
INE84_RS08650	COG1136	(ABC) transporter
INE84_RS08655	COG1136	(ABC) transporter
INE84_RS08655	COG0577	efflux transmembrane transporter activity
INE84_RS08660	COG1136	(ABC) transporter
INE84_RS08665	COG1940	carbohydrate kinase activity
INE84_RS08670	COG0335	large ribosomal subunit rRNA binding
INE84_RS08675	COG0737	Belongs to the 5'-nucleotidase family
INE84_RS08680	COG0737	Belongs to the 5'-nucleotidase family
INE84_RS08685	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS08690	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS08705	COG4948	Mandelate Racemase Muconate Lactonizing
INE84_RS08710	COG0667	Aldo Keto reductase
INE84_RS08715	COG3459	Glycosyltransferase 36 associated
INE84_RS08720	COG3250	beta-galactosidase activity
INE84_RS08725	COG0662	Cupin 2, conserved barrel domain protein
INE84_RS08725	COG2207	Transcriptional regulator
INE84_RS08730	COG3458	cephalosporin-C deacetylase activity
INE84_RS08740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE84_RS08745	COG4771	TonB-dependent receptor
INE84_RS08750	COG0561	phosphatase activity
INE84_RS08765	COG4124	Belongs to the glycosyl hydrolase 26 family
INE84_RS08770	COG1629	transport
INE84_RS08770	COG4206	TonB-dependent receptor
INE84_RS08830	COG4124	Belongs to the glycosyl hydrolase 26 family
INE84_RS08835	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE84_RS08840	COG2211	Major facilitator Superfamily
INE84_RS08845	COG2942	2-epimerase
INE84_RS08855	COG0460	homoserine dehydrogenase
INE84_RS08855	COG0527	aspartate kinase activity
INE84_RS08860	COG2204	response regulator
INE84_RS08870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
INE84_RS08875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
INE84_RS08880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
INE84_RS08890	COG2205	protein histidine kinase activity
INE84_RS08895	COG5002	protein histidine kinase activity
INE84_RS08900	COG2207	Transcriptional regulator
INE84_RS08900	COG4753	response regulator
INE84_RS08935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE84_RS08940	COG0436	Aminotransferase
INE84_RS08950	COG2202	Pas domain
INE84_RS08950	COG2205	protein histidine kinase activity
INE84_RS08955	COG2205	protein histidine kinase activity
INE84_RS08955	COG2202	Pas domain
INE84_RS08960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INE84_RS08985	COG0702	epimerase
INE84_RS08990	COG4771	TonB-dependent receptor
INE84_RS09035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE84_RS09040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INE84_RS09045	COG1160	GTP binding
INE84_RS09050	COG1127	ABC transporter
INE84_RS09055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
INE84_RS09065	COG0724	RNA recognition motif
INE84_RS09070	COG0544	peptidyl-prolyl cis-trans isomerase activity
INE84_RS09075	COG0740	serine-type endopeptidase activity
INE84_RS09080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INE84_RS09085	COG0514	ATP-dependent DNA helicase (RecQ)
INE84_RS09090	COG0517	IMP dehydrogenase activity
INE84_RS09090	COG0516	GMP reductase activity
INE84_RS09095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE84_RS09105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE84_RS09120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INE84_RS09140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE84_RS09145	COG0110	maltose O-acetyltransferase activity
INE84_RS09165	COG1187	pseudouridine synthase activity
INE84_RS09170	COG0017	Asparaginyl-tRNA synthetase
INE84_RS09180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INE84_RS09185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INE84_RS09190	COG0052	Belongs to the universal ribosomal protein uS2 family
INE84_RS09195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INE84_RS09205	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
INE84_RS09210	COG0179	Fumarylacetoacetate (FAA) hydrolase
INE84_RS09225	COG0745	RESPONSE REGULATOR receiver
INE84_RS09225	COG2205	protein histidine kinase activity
INE84_RS09225	COG3292	Two component regulator propeller
INE84_RS09230	COG3119	arylsulfatase activity
INE84_RS09235	COG3119	arylsulfatase activity
INE84_RS09245	COG3119	arylsulfatase activity
INE84_RS09250	COG1629	transport
INE84_RS09250	COG4206	TonB-dependent receptor
INE84_RS09255	COG0702	epimerase
INE84_RS09275	COG3250	beta-galactosidase activity
INE84_RS09280	COG3119	arylsulfatase activity
INE84_RS09295	COG3119	arylsulfatase activity
INE84_RS09300	COG0641	radical SAM
INE84_RS09310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INE84_RS09315	COG1408	metallophosphoesterase
INE84_RS09320	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS09330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE84_RS09335	COG4206	TonB-dependent receptor
INE84_RS09335	COG1629	transport
INE84_RS09350	COG0673	inositol 2-dehydrogenase activity
INE84_RS09355	COG0673	inositol 2-dehydrogenase activity
INE84_RS09390	COG1629	transport
INE84_RS09395	COG0702	epimerase
INE84_RS09420	COG3507	Belongs to the glycosyl hydrolase 43 family
INE84_RS09465	COG0482	sulfurtransferase activity
INE84_RS09475	COG1570	exodeoxyribonuclease VII activity
INE84_RS09490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE84_RS09495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INE84_RS09500	COG0489	protein tyrosine kinase activity
INE84_RS09505	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
INE84_RS09515	COG0673	inositol 2-dehydrogenase activity
INE84_RS09520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE84_RS09555	COG0039	L-malate dehydrogenase activity
INE84_RS09575	COG4771	TonB-dependent receptor
INE84_RS09605	COG3250	beta-galactosidase activity
INE84_RS09610	COG4948	Mandelate Racemase Muconate Lactonizing
INE84_RS09615	COG3458	cephalosporin-C deacetylase activity
INE84_RS09625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE84_RS09630	COG0702	epimerase
INE84_RS09635	COG4771	TonB-dependent receptor
INE84_RS09660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INE84_RS09670	COG0811	peptide transport
INE84_RS09690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INE84_RS09695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INE84_RS09700	COG0739	heme binding
INE84_RS09715	COG0149	triose-phosphate isomerase activity
INE84_RS09725	COG0302	gtp cyclohydrolase
INE84_RS09730	COG0358	DNA primase activity
INE84_RS09735	COG0784	Response regulator, receiver
INE84_RS09735	COG2205	protein histidine kinase activity
INE84_RS09745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
INE84_RS09750	COG0436	Aminotransferase
INE84_RS09770	COG0514	ATP-dependent DNA helicase (RecQ)
INE84_RS09775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INE84_RS09775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INE84_RS09780	COG3022	response to hydroperoxide
INE84_RS09785	COG0823	Involved in the tonB-independent uptake of proteins
INE84_RS09795	COG1629	transport
INE84_RS09795	COG4206	TonB-dependent receptor
INE84_RS09805	COG3537	Alpha-1,2-mannosidase
INE84_RS09815	COG1785	Belongs to the alkaline phosphatase family
INE84_RS09830	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE84_RS09835	COG2133	pyrroloquinoline quinone binding
INE84_RS09835	COG5183	chlorophyll binding
INE84_RS09840	COG2207	Transcriptional regulator
INE84_RS09840	COG1609	Transcriptional regulator
INE84_RS09850	COG0009	L-threonylcarbamoyladenylate synthase
INE84_RS09860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INE84_RS09865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INE84_RS09870	COG0658	competence protein
INE84_RS09870	COG2333	competence protein COMEC
INE84_RS09875	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INE84_RS09885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE84_RS09890	COG1115	amino acid carrier protein
INE84_RS09895	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
INE84_RS09900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE84_RS09910	COG2815	serine threonine protein kinase
INE84_RS09910	COG0515	serine threonine protein kinase
INE84_RS09915	COG0631	protein serine/threonine phosphatase activity
INE84_RS09940	COG2815	serine threonine protein kinase
INE84_RS09940	COG0515	serine threonine protein kinase
INE84_RS09945	COG3275	phosphorelay sensor kinase activity
INE84_RS09950	COG3279	Response regulator of the LytR AlgR family
INE84_RS09980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INE84_RS10005	COG1082	Xylose isomerase domain protein TIM barrel
INE84_RS10025	COG3250	beta-galactosidase activity
INE84_RS10030	COG2818	Glycosylase
INE84_RS10050	COG2205	protein histidine kinase activity
INE84_RS10050	COG3292	Two component regulator propeller
INE84_RS10050	COG0745	RESPONSE REGULATOR receiver
INE84_RS10055	COG1629	transport
INE84_RS10055	COG4206	TonB-dependent receptor
INE84_RS10070	COG2818	Glycosylase
INE84_RS10085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
INE84_RS10090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE84_RS10115	COG0360	Binds together with S18 to 16S ribosomal RNA
INE84_RS10120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INE84_RS10125	COG0359	binds to the 23S rRNA
INE84_RS10130	COG0724	RNA recognition motif
INE84_RS10140	COG0318	PFAM AMP-dependent synthetase and ligase
INE84_RS10145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE84_RS10165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INE84_RS10170	COG1640	4-alpha-glucanotransferase
INE84_RS10180	COG0778	Nitroreductase
INE84_RS10185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INE84_RS10195	COG0860	N-Acetylmuramoyl-L-alanine amidase
INE84_RS10230	COG0463	Glycosyl transferase, family 2
INE84_RS10240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
INE84_RS10255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INE84_RS10260	COG2502	aspartate--ammonia ligase
INE84_RS10270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INE84_RS10280	COG0789	Transcriptional regulator
INE84_RS10300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE84_RS10305	COG0166	Belongs to the GPI family
INE84_RS10310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INE84_RS10315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INE84_RS10335	COG0569	domain protein
INE84_RS10335	COG2985	domain, Protein
INE84_RS10340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE84_RS10345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE84_RS10345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE84_RS10350	COG0551	DNA topoisomerase type I activity
INE84_RS10350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE84_RS10380	COG3681	Belongs to the UPF0597 family
INE84_RS10385	COG1047	Peptidyl-prolyl cis-trans
INE84_RS10390	COG0129	dihydroxy-acid dehydratase activity
INE84_RS10400	COG0440	acetolactate synthase activity
INE84_RS10410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INE84_RS10415	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE84_RS10430	COG0372	Belongs to the citrate synthase family
INE84_RS10445	COG1028	Short-chain dehydrogenase reductase Sdr
INE84_RS10450	COG0205	6-phosphofructokinase activity
INE84_RS10455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INE84_RS10460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INE84_RS10480	COG0084	hydrolase, TatD family'
INE84_RS10490	COG0811	peptide transport
INE84_RS10520	COG1522	sequence-specific DNA binding
INE84_RS10530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INE84_RS10545	COG1595	DNA-templated transcription, initiation
INE84_RS10560	COG4771	TonB-dependent receptor
INE84_RS10595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE84_RS10600	COG0488	(ABC) transporter
INE84_RS10605	COG2204	response regulator
INE84_RS10615	COG0617	tRNA 3'-terminal CCA addition
INE84_RS10625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INE84_RS10635	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INE84_RS10645	COG1575	Belongs to the MenA family. Type 1 subfamily
INE84_RS10650	COG1408	metallophosphoesterase
INE84_RS10660	COG3292	Two component regulator propeller
INE84_RS10660	COG2205	protein histidine kinase activity
INE84_RS10660	COG0745	RESPONSE REGULATOR receiver
INE84_RS10665	COG1940	carbohydrate kinase activity
INE84_RS10670	COG0363	glucosamine-6-phosphate deaminase activity
INE84_RS10685	COG1629	transport
INE84_RS10710	COG4771	TonB-dependent receptor
INE84_RS10730	COG1082	Xylose isomerase domain protein TIM barrel
INE84_RS10740	COG0006	proline dipeptidase activity
INE84_RS10750	COG0632	four-way junction helicase activity
INE84_RS10755	COG0673	inositol 2-dehydrogenase activity
INE84_RS10760	COG0750	zinc metalloprotease
INE84_RS10765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INE84_RS10775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INE84_RS10780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INE84_RS10790	COG1214	PFAM Peptidase M22, glycoprotease
INE84_RS10800	COG0194	GDP metabolic process
INE84_RS10810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INE84_RS10815	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE84_RS10820	COG0523	cobalamin synthesis protein
INE84_RS10825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INE84_RS10840	COG2873	o-acetylhomoserine
INE84_RS10855	COG4977	sequence-specific DNA binding
INE84_RS10855	COG1917	Cupin 2, conserved barrel domain protein
INE84_RS10870	COG1733	regulation of RNA biosynthetic process
INE84_RS10885	COG0490	domain, Protein
INE84_RS10885	COG0471	metal ion transport
INE84_RS10890	COG1501	Belongs to the glycosyl hydrolase 31 family
INE84_RS10905	COG1136	(ABC) transporter
INE84_RS10925	COG2211	Major facilitator Superfamily
INE84_RS10930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE84_RS10955	COG1674	ftsk spoiiie
INE84_RS10965	COG0492	ferredoxin-NADP+ reductase activity
INE84_RS11010	COG1595	DNA-templated transcription, initiation
INE84_RS11025	COG3956	TIGRFAM MazG family protein
INE84_RS11035	COG0525	valine-tRNA ligase activity
INE84_RS11065	COG1629	transport
INE84_RS11070	COG0561	phosphatase activity
INE84_RS11100	COG0653	protein targeting
INE84_RS11105	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
INE84_RS11135	COG1253	flavin adenine dinucleotide binding
INE84_RS11145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INE84_RS11155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
INE84_RS11195	COG2706	6-phosphogluconolactonase activity
INE84_RS11200	COG1472	Belongs to the glycosyl hydrolase 3 family
INE84_RS11235	COG4584	PFAM Integrase catalytic
INE84_RS11240	COG1484	DNA-dependent DNA replication
INE84_RS11270	COG2217	Heavy metal translocating P-type atpase
INE84_RS11285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE84_RS11290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
INE84_RS11295	COG0534	Mate efflux family protein
INE84_RS11340	COG4974	Belongs to the 'phage' integrase family
INE84_RS11375	COG0551	DNA topoisomerase type I activity
INE84_RS11375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE84_RS11390	COG1484	DNA-dependent DNA replication
INE84_RS11395	COG4584	PFAM Integrase catalytic
INE84_RS11440	COG0784	Response regulator, receiver
INE84_RS11440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE84_RS11440	COG2198	Histidine kinase
INE84_RS11440	COG2205	protein histidine kinase activity
INE84_RS11445	COG2204	response regulator
INE84_RS11560	COG0358	DNA primase activity
INE84_RS11635	COG0110	maltose O-acetyltransferase activity
INE84_RS11665	COG1063	alcohol dehydrogenase
INE84_RS11700	COG0582	viral genome integration into host DNA
INE84_RS11705	COG1215	transferase activity, transferring glycosyl groups
INE84_RS11755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INE84_RS11760	COG1410	methionine synthase
INE84_RS11760	COG0646	methionine synthase
INE84_RS11765	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE84_RS11770	COG0572	uridine kinase
INE84_RS11780	COG4232	protein-disulfide reductase activity
INE84_RS11805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INE84_RS11810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INE84_RS11815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE84_RS11820	COG0131	Imidazoleglycerol-phosphate dehydratase
INE84_RS11825	COG4651	solute:proton antiporter activity
INE84_RS11825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE84_RS11830	COG0673	inositol 2-dehydrogenase activity
INE84_RS11835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INE84_RS11840	COG0193	aminoacyl-tRNA hydrolase activity
INE84_RS11845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INE84_RS11855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INE84_RS11860	COG1862	Preprotein translocase
INE84_RS11870	COG0237	dephospho-CoA kinase activity
INE84_RS11880	COG0542	response to heat
INE84_RS11890	COG0583	DNA-binding transcription factor activity
INE84_RS11895	COG2855	membrane
INE84_RS11910	COG1595	DNA-templated transcription, initiation
INE84_RS11925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INE84_RS11930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
INE84_RS11955	COG0443	Heat shock 70 kDa protein
INE84_RS12035	COG1484	DNA-dependent DNA replication
INE84_RS12040	COG4584	PFAM Integrase catalytic
INE84_RS12045	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE84_RS12050	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE84_RS12065	COG4974	Belongs to the 'phage' integrase family
INE84_RS12070	COG4974	Belongs to the 'phage' integrase family
INE84_RS12075	COG4974	Belongs to the 'phage' integrase family
INE84_RS12095	COG1373	ATPase (AAA superfamily
INE84_RS12155	COG4584	PFAM Integrase catalytic
INE84_RS12160	COG1484	DNA-dependent DNA replication
INE84_RS12170	COG0561	phosphatase activity
INE84_RS12190	COG4139	cobalamin transport
INE84_RS12225	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
INE84_RS12230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE84_RS12275	COG0745	RESPONSE REGULATOR receiver
INE84_RS12280	COG5002	protein histidine kinase activity
INE84_RS12280	COG3850	Histidine kinase
INE84_RS12295	COG1760	l-serine dehydratase
INE84_RS12300	COG1193	negative regulation of DNA recombination
INE84_RS12310	COG0210	DNA helicase
INE84_RS12350	COG4804	nuclease activity
INE84_RS12425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INE84_RS12445	COG1484	DNA-dependent DNA replication
INE84_RS12450	COG4584	PFAM Integrase catalytic
INE84_RS12455	COG2205	protein histidine kinase activity
INE84_RS12455	COG0745	RESPONSE REGULATOR receiver
INE84_RS12455	COG3292	Two component regulator propeller
INE84_RS12470	COG4771	TonB-dependent receptor
INE84_RS12480	COG2755	lipolytic protein G-D-S-L family
INE84_RS12490	COG3250	beta-galactosidase activity
INE84_RS12500	COG3292	Two component regulator propeller
INE84_RS12500	COG2205	protein histidine kinase activity
INE84_RS12500	COG0745	RESPONSE REGULATOR receiver
INE84_RS12510	COG4206	TonB-dependent receptor
INE84_RS12510	COG1629	transport
INE84_RS12515	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE84_RS12520	COG3507	Belongs to the glycosyl hydrolase 43 family
INE84_RS12530	COG3250	beta-galactosidase activity
INE84_RS12540	COG1312	Catalyzes the dehydration of D-mannonate
INE84_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
INE84_RS12550	COG2205	protein histidine kinase activity
INE84_RS12550	COG0784	Response regulator, receiver
INE84_RS12625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE84_RS12635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INE84_RS12650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INE84_RS12655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INE84_RS12660	COG3119	arylsulfatase activity
INE84_RS12675	COG0037	tRNA processing
INE84_RS12680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INE84_RS12680	COG1918	ferrous iron import across plasma membrane
INE84_RS12705	COG0346	lactoylglutathione lyase activity
INE84_RS12720	COG1741	Belongs to the pirin family
INE84_RS12725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE84_RS12750	COG0702	epimerase
INE84_RS12755	COG1629	transport
INE84_RS12755	COG4206	TonB-dependent receptor
INE84_RS12765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
INE84_RS12770	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
INE84_RS12775	COG0148	phosphopyruvate hydratase activity
INE84_RS12800	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
INE84_RS12810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE84_RS12830	COG1151	hydroxylamine reductase activity
INE84_RS12845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
INE84_RS12880	COG0714	Associated with various cellular activities
INE84_RS12890	COG2207	Transcriptional regulator
INE84_RS12890	COG4753	response regulator
INE84_RS12895	COG0561	phosphatase activity
INE84_RS12950	COG0788	formyltetrahydrofolate deformylase activity
INE84_RS12955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INE84_RS12960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INE84_RS12965	COG0107	imidazoleglycerol-phosphate synthase activity
INE84_RS12970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INE84_RS12970	COG0140	phosphoribosyl-ATP diphosphatase activity
INE84_RS12975	COG2884	Cell division ATP-binding protein ftsE
INE84_RS12980	COG0527	aspartate kinase activity
INE84_RS12985	COG0019	diaminopimelate decarboxylase activity
INE84_RS12995	COG0156	8-amino-7-oxononanoate synthase activity
INE84_RS13015	COG0321	lipoyl(octanoyl) transferase activity
INE84_RS13015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE84_RS13030	COG0592	DNA-directed DNA polymerase activity
INE84_RS13045	COG0497	DNA recombination
INE84_RS13050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE84_RS13070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
INE84_RS13080	COG0167	dihydroorotate dehydrogenase activity
INE84_RS13085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INE84_RS13120	COG1216	Glycosyl transferase, family 2
INE84_RS13160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
INE84_RS13170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE84_RS13175	COG0110	maltose O-acetyltransferase activity
INE84_RS13180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE84_RS13195	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
INE84_RS13200	COG0586	Pfam SNARE associated Golgi protein
INE84_RS13210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE84_RS13215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INE84_RS13220	COG0573	inorganic phosphate transmembrane transporter activity
INE84_RS13225	COG0581	inorganic phosphate transmembrane transporter activity
INE84_RS13230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INE84_RS13235	COG0704	Plays a role in the regulation of phosphate uptake
INE84_RS13325	COG0358	DNA primase activity
INE84_RS13460	COG2205	protein histidine kinase activity
INE84_RS13460	COG2198	Histidine kinase
INE84_RS13460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE84_RS13460	COG0784	Response regulator, receiver
INE84_RS13480	COG0551	DNA topoisomerase type I activity
INE84_RS13480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE84_RS13515	COG4974	Belongs to the 'phage' integrase family
INE84_RS13525	COG4948	Mandelate Racemase Muconate Lactonizing
INE84_RS13535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INE84_RS13540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INE84_RS13555	COG0446	pyridine nucleotide-disulphide oxidoreductase
INE84_RS13645	COG0247	lactate metabolic process
INE84_RS13645	COG0277	FAD linked oxidase domain protein
INE84_RS13650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE84_RS13665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
INE84_RS13690	COG1595	DNA-templated transcription, initiation
INE84_RS13715	COG0531	amino acid
INE84_RS13725	COG2066	Belongs to the glutaminase family
INE84_RS13730	COG0076	glutamate decarboxylase activity
INE84_RS13740	COG0686	Belongs to the AlaDH PNT family
INE84_RS13745	COG0739	heme binding
INE84_RS13755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE84_RS13800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INE84_RS13805	COG0488	(ABC) transporter
INE84_RS13810	COG0295	cytidine deaminase activity
INE84_RS13815	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE84_RS13820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE84_RS13825	COG0577	efflux transmembrane transporter activity
INE84_RS13835	COG1136	(ABC) transporter
INE84_RS13840	COG1136	(ABC) transporter
INE84_RS13840	COG0577	efflux transmembrane transporter activity
INE84_RS13855	COG0577	efflux transmembrane transporter activity
INE84_RS13875	COG2205	protein histidine kinase activity
INE84_RS13875	COG0784	Response regulator, receiver
INE84_RS13885	COG0436	Aminotransferase
INE84_RS13890	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE84_RS13895	COG1215	transferase activity, transferring glycosyl groups
INE84_RS13905	COG2226	methyltransferase
INE84_RS13920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE84_RS13920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
INE84_RS13950	COG0305	Participates in initiation and elongation during chromosome replication
INE84_RS13965	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE84_RS14010	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
INE84_RS14040	COG0058	SHG alpha-glucan phosphorylase activity
INE84_RS14045	COG0716	FMN binding
INE84_RS14055	COG0588	phosphoglycerate mutase activity
INE84_RS14085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE84_RS14090	COG0228	four-way junction DNA binding
INE84_RS14100	COG2721	sulfolactate sulfo-lyase activity
INE84_RS14105	COG1609	Transcriptional regulator
INE84_RS14135	COG1216	Glycosyl transferase, family 2
INE84_RS14140	COG1216	Glycosyl transferase, family 2
INE84_RS14145	COG0438	transferase activity, transferring glycosyl groups
INE84_RS14205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE84_RS14250	COG0745	RESPONSE REGULATOR receiver
INE84_RS14260	COG0252	asparaginase activity
INE84_RS14265	COG0159	tryptophan synthase activity
INE84_RS14270	COG0135	phosphoribosylanthranilate isomerase activity
INE84_RS14275	COG0134	indole-3-glycerol-phosphate synthase activity
INE84_RS14280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INE84_RS14285	COG0512	Glutamine amidotransferase of anthranilate synthase
INE84_RS14285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INE84_RS14290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INE84_RS14295	COG0133	tryptophan synthase activity
INE84_RS14315	COG0004	ammonium transporteR
INE84_RS14320	COG0347	Belongs to the P(II) protein family
INE84_RS14330	COG0436	Aminotransferase
INE84_RS14385	COG2244	polysaccharide biosynthetic process
INE84_RS14390	COG0110	maltose O-acetyltransferase activity
INE84_RS14400	COG0438	transferase activity, transferring glycosyl groups
INE84_RS14410	COG1442	glycosyl transferase family 8
INE84_RS14410	COG1216	Glycosyl transferase, family 2
INE84_RS14430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE84_RS14435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE84_RS14465	COG0367	asparagine synthase
INE84_RS14475	COG0069	glutamate synthase activity
INE84_RS14475	COG0070	glutamate synthase
INE84_RS14475	COG0067	glutamate synthase
INE84_RS14480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INE84_RS14490	COG0505	Belongs to the CarA family
INE84_RS14495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE84_RS14555	COG0484	heat shock protein binding
INE84_RS14665	COG1309	transcriptional regulator
INE84_RS14730	COG3344	reverse transcriptase
INE84_RS14850	COG0484	heat shock protein binding
INE84_RS14905	COG0358	DNA primase activity
INE84_RS14990	COG1192	Involved in chromosome partitioning
INE84_RS15035	COG1373	ATPase (AAA superfamily
INE84_RS15050	COG0551	DNA topoisomerase type I activity
INE84_RS15050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE84_RS15100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE84_RS15140	COG0438	transferase activity, transferring glycosyl groups
INE84_RS15150	COG3274	enterobacterial common antigen metabolic process
INE84_RS15155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INE84_RS15160	COG1028	Short-chain dehydrogenase reductase Sdr
INE84_RS15165	COG0438	transferase activity, transferring glycosyl groups
INE84_RS15210	COG0110	maltose O-acetyltransferase activity
INE84_RS15230	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INE84_RS15235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE84_RS15240	COG0662	Cupin 2, conserved barrel domain protein
INE84_RS15240	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
INE84_RS15250	COG5002	protein histidine kinase activity
INE84_RS15250	COG0784	Response regulator, receiver
INE84_RS15255	COG2204	response regulator
INE84_RS15280	COG4974	Belongs to the 'phage' integrase family
INE84_RS15285	COG4974	Belongs to the 'phage' integrase family
INE84_RS15290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INE84_RS15295	COG2207	Transcriptional regulator
INE84_RS15295	COG1917	Cupin 2, conserved barrel domain protein
INE84_RS15310	COG1131	(ABC) transporter
INE84_RS15315	COG0842	Transport permease protein
INE84_RS15325	COG2755	lipolytic protein G-D-S-L family
INE84_RS15325	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE84_RS15335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INE84_RS15350	COG4771	TonB-dependent receptor
INE84_RS15355	COG0702	epimerase
INE84_RS15375	COG1082	Xylose isomerase domain protein TIM barrel
INE84_RS15380	COG0318	PFAM AMP-dependent synthetase and ligase
INE84_RS15385	COG3263	regulation of cellular component size
INE84_RS15390	COG3852	Histidine kinase
INE84_RS15415	COG1136	(ABC) transporter
INE84_RS15420	COG0577	efflux transmembrane transporter activity
INE84_RS15420	COG1136	(ABC) transporter
INE84_RS15430	COG0534	Mate efflux family protein
INE84_RS15435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE84_RS15440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
INE84_RS15450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
INE84_RS15455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INE84_RS15465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
INE84_RS15475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
INE84_RS15480	COG0305	Participates in initiation and elongation during chromosome replication
INE84_RS15490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INE84_RS15495	COG1058	Belongs to the CinA family
INE84_RS15495	COG1546	Belongs to the CinA family
INE84_RS15500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INE84_RS15505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INE84_RS15515	COG0552	protein localization to endoplasmic reticulum
INE84_RS15520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE84_RS15535	COG0714	Associated with various cellular activities
INE84_RS15550	COG2304	oxidoreductase activity
INE84_RS15595	COG0542	response to heat
INE84_RS15620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE84_RS15625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INE84_RS15630	COG0336	Belongs to the RNA methyltransferase TrmD family
INE84_RS15635	COG0167	dihydroorotate dehydrogenase activity
INE84_RS15640	COG0543	2 iron, 2 sulfur cluster binding
INE84_RS15655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE84_RS15680	COG1538	Outer membrane efflux protein
INE84_RS15700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INE84_RS15715	COG0390	transport system, permease component
INE84_RS15720	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
INE84_RS15730	COG2957	Belongs to the agmatine deiminase family
INE84_RS15745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INE84_RS15750	COG1597	lipid kinase activity
INE84_RS15755	COG0156	8-amino-7-oxononanoate synthase activity
INE84_RS15760	COG0501	Belongs to the peptidase M48B family
INE84_RS15780	COG4584	PFAM Integrase catalytic
INE84_RS15785	COG1484	DNA-dependent DNA replication
INE84_RS15795	COG4974	Belongs to the 'phage' integrase family
INE84_RS15805	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
INE84_RS15810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
INE84_RS15815	COG0343	queuine tRNA-ribosyltransferase activity
INE84_RS15830	COG3830	Belongs to the UPF0237 family
INE84_RS15830	COG0560	Phosphoserine phosphatase
INE84_RS15835	COG0513	Belongs to the DEAD box helicase family
INE84_RS15870	COG0246	Mannitol dehydrogenase
INE84_RS15875	COG1609	Transcriptional regulator
INE84_RS15880	COG1904	glucuronate isomerase
INE84_RS15895	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE84_RS15905	COG2249	NAD(P)H dehydrogenase (quinone) activity
INE84_RS15915	COG3387	PFAM Glycoside hydrolase 15-related
INE84_RS15935	COG2194	sulfuric ester hydrolase activity
INE84_RS15945	COG1252	NADH dehydrogenase
INE84_RS15965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE84_RS15980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INE84_RS15990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INE84_RS16020	COG3153	acetyltransferase
INE84_RS16020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE84_RS16025	COG2814	Major facilitator Superfamily
INE84_RS16025	COG0477	Major facilitator Superfamily
INE84_RS16030	COG2115	Belongs to the xylose isomerase family
INE84_RS16045	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INE84_RS16060	COG0352	thiamine-phosphate diphosphorylase activity
INE84_RS16065	COG2022	thiamine diphosphate biosynthetic process
INE84_RS16070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
INE84_RS16085	COG0352	thiamine-phosphate diphosphorylase activity
INE84_RS16090	COG0351	phosphomethylpyrimidine kinase
INE84_RS16135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INE84_RS16205	COG1484	DNA-dependent DNA replication
INE84_RS16210	COG4584	PFAM Integrase catalytic
INE84_RS16235	COG4584	PFAM Integrase catalytic
INE84_RS16240	COG1484	DNA-dependent DNA replication
INE84_RS16255	COG0393	Putative heavy-metal-binding
INE84_RS16295	COG0358	DNA primase activity
INE84_RS16370	COG2003	Belongs to the UPF0758 family
INE84_RS16530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
INE84_RS16545	COG2205	protein histidine kinase activity
INE84_RS16550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INE84_RS16565	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
INE84_RS16575	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INE84_RS16580	COG0540	Belongs to the ATCase OTCase family
INE84_RS16585	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
INE84_RS16600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INE84_RS16605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
INE84_RS16640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE84_RS16645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INE84_RS16650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INE84_RS16655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE84_RS16660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INE84_RS16665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE84_RS16670	COG0356	it plays a direct role in the translocation of protons across the membrane
INE84_RS16690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INE84_RS16695	COG4657	Part of a membrane complex involved in electron transport
INE84_RS16700	COG4660	Part of a membrane complex involved in electron transport
INE84_RS16705	COG4659	FMN binding
INE84_RS16710	COG4658	electron transport chain
INE84_RS16715	COG4656	Part of a membrane complex involved in electron transport
INE84_RS16735	COG0504	CTP synthase activity
INE84_RS16750	COG0823	Involved in the tonB-independent uptake of proteins
INE84_RS16750	COG1506	peptidase
INE84_RS16760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE84_RS16765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE84_RS16785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
INE84_RS16835	COG0463	Glycosyl transferase, family 2
INE84_RS16835	COG1216	Glycosyl transferase, family 2
INE84_RS16845	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INE84_RS16910	COG0442	prolyl-tRNA aminoacylation
INE84_RS16915	COG2731	YhcH YjgK YiaL family protein
INE84_RS16920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
INE84_RS16940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE84_RS16945	COG4771	TonB-dependent receptor
INE84_RS16950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE84_RS16955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE84_RS16960	COG2186	Transcriptional regulator
INE84_RS16975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
INE84_RS16990	COG2202	Pas domain
INE84_RS16990	COG2205	protein histidine kinase activity
INE84_RS16995	COG2205	protein histidine kinase activity
INE84_RS16995	COG2202	Pas domain
INE84_RS17000	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
INE84_RS17010	COG1492	cobalamin metabolic process
INE84_RS17030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
INE84_RS17035	COG2096	Adenosyltransferase
INE84_RS17200	COG4974	Belongs to the 'phage' integrase family
INE84_RS17205	COG4974	Belongs to the 'phage' integrase family
INE84_RS17215	COG1484	DNA-dependent DNA replication
INE84_RS17220	COG4584	PFAM Integrase catalytic
INE84_RS17225	COG4974	Belongs to the 'phage' integrase family
INE84_RS17230	COG1484	DNA-dependent DNA replication
INE84_RS17235	COG4584	PFAM Integrase catalytic
INE84_RS17255	COG3344	reverse transcriptase
INE84_RS17285	COG3209	COG3209 Rhs family protein
INE84_RS17350	COG0542	response to heat
INE84_RS17395	COG1192	Involved in chromosome partitioning
INE84_RS17410	COG1475	DNA binding
INE84_RS17565	COG4974	Belongs to the 'phage' integrase family
INE84_RS17575	COG4974	Belongs to the 'phage' integrase family
INE84_RS17580	COG4974	Belongs to the 'phage' integrase family
INE84_RS17640	COG1629	transport
INE84_RS17645	COG1192	Involved in chromosome partitioning
INE84_RS17670	COG1120	ATPase activity
INE84_RS17675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INE84_RS17720	COG1797	cobyrinic acid a,c-diamide synthase activity
INE84_RS17730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
INE84_RS17740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE84_RS17750	COG0439	Biotin carboxylase
INE84_RS17795	COG4771	TonB-dependent receptor
INE84_RS17825	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
INE84_RS17835	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
INE84_RS17840	COG0534	Mate efflux family protein
INE84_RS17845	COG1120	ATPase activity
INE84_RS17860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE84_RS17865	COG3059	membrane
INE84_RS17890	COG0657	acetylesterase activity
INE84_RS17890	COG2755	lipolytic protein G-D-S-L family
INE84_RS17895	COG3250	beta-galactosidase activity
INE84_RS17910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE84_RS17915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE84_RS17920	COG1216	Glycosyl transferase, family 2
INE84_RS17925	COG0438	transferase activity, transferring glycosyl groups
INE84_RS17930	COG3475	LICD family
INE84_RS17965	COG3594	Acyltransferase
INE84_RS18000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
INE84_RS18035	COG2089	acid synthase
INE84_RS18040	COG0151	Belongs to the GarS family
INE84_RS18060	COG1083	cytidylyl-transferase
INE84_RS18065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE84_RS18070	COG1086	Polysaccharide biosynthesis protein
INE84_RS18090	COG1695	Transcriptional regulator
INE84_RS18095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INE84_RS18105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE84_RS18120	COG3104	oligopeptide transport
INE84_RS18125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INE84_RS18130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INE84_RS18135	COG1388	LysM domain
INE84_RS18135	COG3942	CHAP domain
INE84_RS18165	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE84_RS18170	COG0556	nucleotide-excision repair
INE84_RS18195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE84_RS18200	COG1475	DNA binding
INE84_RS18205	COG3969	phosphoadenosine phosphosulfate
INE84_RS18215	COG2059	Chromate
INE84_RS18225	COG0738	Major facilitator superfamily
INE84_RS18240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE84_RS18255	COG0110	maltose O-acetyltransferase activity
INE84_RS18315	COG0210	DNA helicase
INE84_RS18320	COG4584	PFAM Integrase catalytic
INE84_RS18325	COG1484	DNA-dependent DNA replication
INE84_RS18355	COG4771	TonB-dependent receptor
INE84_RS18360	COG1678	Uncharacterized ACR, COG1678
INE84_RS18375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INE84_RS18435	COG0352	thiamine-phosphate diphosphorylase activity
INE84_RS18440	COG5002	protein histidine kinase activity
INE84_RS18440	COG2205	protein histidine kinase activity
INE84_RS18440	COG0784	Response regulator, receiver
INE84_RS18445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INE84_RS18445	COG0574	Belongs to the PEP-utilizing enzyme family
INE84_RS18450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INE84_RS18455	COG0564	pseudouridine synthase activity
INE84_RS18470	COG2814	Major facilitator Superfamily
INE84_RS18495	COG0420	3'-5' exonuclease activity
INE84_RS18505	COG0024	Methionine aminopeptidase
INE84_RS18520	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE84_RS18530	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE84_RS18535	COG1805	sodium ion transport
INE84_RS18540	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE84_RS18560	COG2205	protein histidine kinase activity
INE84_RS18560	COG0784	Response regulator, receiver
INE84_RS18575	COG0612	Peptidase, M16
INE84_RS18595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INE84_RS18600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE84_RS18615	COG5002	protein histidine kinase activity
INE84_RS18620	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INE84_RS18625	COG0481	GTPase activity
INE84_RS18640	COG0708	Exodeoxyribonuclease III
INE84_RS18645	COG1914	H( )-stimulated, divalent metal cation uptake system
INE84_RS18655	COG0217	transcriptional regulatory protein
INE84_RS18660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE84_RS18660	COG0072	phenylalanine-tRNA ligase activity
INE84_RS18675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE84_RS18715	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INE84_RS18740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INE84_RS18745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
INE84_RS18780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
INE84_RS18790	COG1083	cytidylyl-transferase
INE84_RS18795	COG2089	acid synthase
INE84_RS18800	COG1442	glycosyl transferase family 8
INE84_RS18800	COG1216	Glycosyl transferase, family 2
INE84_RS18810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE84_RS18815	COG1086	Polysaccharide biosynthesis protein
INE84_RS18845	COG0321	lipoyl(octanoyl) transferase activity
INE84_RS18880	COG0357	Ribosomal RNA small subunit methyltransferase G
INE84_RS18885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INE84_RS18890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE84_RS18890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE84_RS18900	COG1131	(ABC) transporter
INE84_RS18910	COG1725	Transcriptional regulator
INE84_RS18920	COG0778	Nitroreductase
INE84_RS18930	COG1739	Uncharacterized protein family UPF0029
INE84_RS18945	COG1929	Belongs to the glycerate kinase type-1 family
INE84_RS18950	COG0534	Mate efflux family protein
INE84_RS18960	COG0545	Peptidyl-prolyl cis-trans isomerase
INE84_RS18975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE84_RS18980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INE84_RS18985	COG0513	Belongs to the DEAD box helicase family
INE84_RS19005	COG0488	(ABC) transporter
INE84_RS19090	COG0740	serine-type endopeptidase activity
INE84_RS19110	COG4383	Mu-like prophage protein gp29
INE84_RS19245	COG4221	oxidoreductase activity
INE84_RS19250	COG3842	ATPase activity
INE84_RS19255	COG1176	ABC-type spermidine putrescine transport system, permease component I
INE84_RS19260	COG1177	transmembrane transport
INE84_RS19270	COG0534	Mate efflux family protein
INE84_RS19280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INE84_RS19310	COG1136	(ABC) transporter
INE84_RS19315	COG0577	efflux transmembrane transporter activity
INE84_RS19315	COG1136	(ABC) transporter
INE84_RS19325	COG3279	Response regulator of the LytR AlgR family
INE84_RS19335	COG0259	pyridoxamine-phosphate oxidase activity
INE84_RS19345	COG0363	glucosamine-6-phosphate deaminase activity
INE84_RS19350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INE84_RS19355	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INE84_RS19370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE84_RS19380	COG0318	PFAM AMP-dependent synthetase and ligase
INE84_RS19385	COG3119	arylsulfatase activity
INE84_RS19395	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
INE84_RS19405	COG0306	phosphate transporter
INE84_RS19415	COG0586	Pfam SNARE associated Golgi protein
INE84_RS19440	COG0534	Mate efflux family protein
INE84_RS19525	COG1215	transferase activity, transferring glycosyl groups
INE84_RS19555	COG1216	Glycosyl transferase, family 2
INE84_RS19610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE84_RS19615	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
INE84_RS19620	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INE84_RS19650	COG4977	sequence-specific DNA binding
INE84_RS19650	COG1917	Cupin 2, conserved barrel domain protein
INE84_RS19655	COG4771	TonB-dependent receptor
INE84_RS19680	COG2183	response to ionizing radiation
INE84_RS19695	COG0488	(ABC) transporter
INE84_RS19700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INE84_RS19705	COG0484	heat shock protein binding
INE84_RS19715	COG0457	Tetratricopeptide repeat
INE84_RS19730	COG0702	epimerase
INE84_RS19735	COG4771	TonB-dependent receptor
INE84_RS19740	COG2942	2-epimerase
INE84_RS19745	COG2814	Major facilitator Superfamily
INE84_RS19755	COG1940	carbohydrate kinase activity
INE84_RS19790	COG3507	Belongs to the glycosyl hydrolase 43 family
INE84_RS19800	COG0823	Involved in the tonB-independent uptake of proteins
INE84_RS19805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INE84_RS19815	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE84_RS19815	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
INE84_RS19815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE84_RS19815	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE84_RS19820	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE84_RS19825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INE84_RS19830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INE84_RS19835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INE84_RS19840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INE84_RS19850	COG0242	peptide deformylase activity
INE84_RS19855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INE84_RS19885	COG4974	Belongs to the 'phage' integrase family
INE84_RS19890	COG4974	Belongs to the 'phage' integrase family
INE84_RS20020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INE84_RS20070	COG2895	sulfate adenylyltransferase (ATP) activity
INE84_RS20075	COG0175	sulfate reduction
INE84_RS20080	COG0529	Catalyzes the synthesis of activated sulfate
INE84_RS20085	COG0471	metal ion transport
INE84_RS20085	COG3273	potassium ion transport
INE84_RS20090	COG1218	3'(2'),5'-bisphosphate nucleotidase
INE84_RS20105	COG0513	Belongs to the DEAD box helicase family
INE84_RS20125	COG1482	cell wall glycoprotein biosynthetic process
INE84_RS20140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INE84_RS20165	COG2160	L-arabinose isomerase activity
INE84_RS20170	COG1070	Carbohydrate kinase
INE84_RS20185	COG0698	ribose 5-phosphate isomerase
INE84_RS20225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE84_RS20230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INE84_RS20230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE84_RS20235	COG4974	Belongs to the 'phage' integrase family
INE84_RS20270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE84_RS20270	COG0551	DNA topoisomerase type I activity
INE84_RS20310	COG0741	lytic transglycosylase activity
INE84_RS20310	COG1196	nuclear chromosome segregation
INE84_RS20310	COG0739	heme binding
INE84_RS20330	COG1475	DNA binding
INE84_RS20420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INE84_RS20445	COG4974	Belongs to the 'phage' integrase family
INE84_RS20450	COG4974	Belongs to the 'phage' integrase family
INE84_RS20455	COG4974	Belongs to the 'phage' integrase family
INE84_RS20505	COG3177	Filamentation induced by cAMP protein fic
INE84_RS20545	COG1192	Involved in chromosome partitioning
INE84_RS20550	COG4974	Belongs to the 'phage' integrase family
INE84_RS20575	COG0629	single-stranded DNA binding
INE84_RS20645	COG0662	Cupin 2, conserved barrel domain protein
INE84_RS20645	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
INE84_RS20660	COG1216	Glycosyl transferase, family 2
INE84_RS20660	COG1442	glycosyl transferase family 8
INE84_RS20670	COG0438	transferase activity, transferring glycosyl groups
INE84_RS20700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INE84_RS20705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE84_RS20815	COG1192	Involved in chromosome partitioning
INE84_RS20830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INE84_RS20835	COG2205	protein histidine kinase activity
INE84_RS20835	COG0784	Response regulator, receiver
INE84_RS20850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INE84_RS20860	COG0656	L-ascorbic acid biosynthetic process
INE84_RS20895	COG2003	Belongs to the UPF0758 family
INE84_RS20930	COG2337	Toxic component of a toxin-antitoxin (TA) module
INE84_RS20940	COG0776	regulation of translation
INE84_RS21000	COG4474	Belongs to the UPF0398 family
INE84_RS21005	COG3385	transposase activity
INE84_RS21090	COG0629	single-stranded DNA binding
INE84_RS21100	COG4974	Belongs to the 'phage' integrase family
INE84_RS21105	COG4974	Belongs to the 'phage' integrase family
INE84_RS21110	COG4974	Belongs to the 'phage' integrase family