locus-tag	class	description
INE90_RS00025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INE90_RS00070	COG0582	viral genome integration into host DNA
INE90_RS00080	COG0606	chelatase, subunit chli
INE90_RS00095	COG4974	Belongs to the 'phage' integrase family
INE90_RS00100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
INE90_RS00115	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE90_RS00120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INE90_RS00130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE90_RS00135	COG1854	S-ribosylhomocysteine lyase activity
INE90_RS00140	COG0318	PFAM AMP-dependent synthetase and ligase
INE90_RS00165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INE90_RS00170	COG1217	gtp-binding protein TYPA
INE90_RS00180	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INE90_RS00185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INE90_RS00215	COG4206	TonB-dependent receptor
INE90_RS00215	COG1629	transport
INE90_RS00220	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE90_RS00225	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE90_RS00225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE90_RS00235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INE90_RS00240	COG0339	signal peptide processing
INE90_RS00265	COG0018	arginyl-trna synthetase
INE90_RS00285	COG2816	NAD+ diphosphatase activity
INE90_RS00325	COG0483	inositol monophosphate 1-phosphatase activity
INE90_RS00330	COG1040	competence protein
INE90_RS00350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE90_RS00355	COG0793	Belongs to the peptidase S41A family
INE90_RS00375	COG4771	TonB-dependent receptor
INE90_RS00380	COG0702	epimerase
INE90_RS00405	COG3119	arylsulfatase activity
INE90_RS00425	COG2066	Belongs to the glutaminase family
INE90_RS00430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INE90_RS00435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INE90_RS00440	COG0509	glycine decarboxylation via glycine cleavage system
INE90_RS00455	COG0006	proline dipeptidase activity
INE90_RS00460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE90_RS00465	COG2205	protein histidine kinase activity
INE90_RS00475	COG1283	sodium-dependent phosphate transmembrane transporter activity
INE90_RS00480	COG1773	rubredoxin
INE90_RS00485	COG0784	Response regulator, receiver
INE90_RS00485	COG2205	protein histidine kinase activity
INE90_RS00490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INE90_RS00495	COG1011	Hydrolase
INE90_RS00500	COG0196	riboflavin kinase activity
INE90_RS00510	COG1266	CAAX protease self-immunity
INE90_RS00540	COG3655	Transcriptional regulator
INE90_RS00545	COG2166	iron-sulfur cluster assembly
INE90_RS00560	COG0280	phosphate acetyltransferase
INE90_RS00565	COG3426	butyrate kinase activity
INE90_RS00570	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
INE90_RS00570	COG3408	Glycogen debranching enzyme
INE90_RS00580	COG2431	L-lysine efflux transmembrane transporter activity
INE90_RS00595	COG4206	TonB-dependent receptor
INE90_RS00595	COG1629	transport
INE90_RS00605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INE90_RS00615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
INE90_RS00625	COG0187	DNA topoisomerase II activity
INE90_RS00630	COG0268	Binds directly to 16S ribosomal RNA
INE90_RS00640	COG1381	Involved in DNA repair and RecF pathway recombination
INE90_RS00645	COG1610	YqeY-like protein
INE90_RS00650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INE90_RS00655	COG0849	cell division
INE90_RS00665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INE90_RS00670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INE90_RS00675	COG0772	Belongs to the SEDS family
INE90_RS00680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INE90_RS00685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE90_RS00690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INE90_RS00695	COG0768	penicillin binding
INE90_RS00710	COG2001	Belongs to the MraZ family
INE90_RS00745	COG0756	dUTP diphosphatase activity
INE90_RS00760	COG4942	peptidase
INE90_RS00765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INE90_RS00775	COG1022	Amp-dependent synthetase and ligase
INE90_RS00780	COG4206	TonB-dependent receptor
INE90_RS00780	COG1629	transport
INE90_RS00810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INE90_RS00815	COG2954	triphosphatase activity
INE90_RS00845	COG0702	epimerase
INE90_RS00850	COG4771	TonB-dependent receptor
INE90_RS00875	COG1629	transport
INE90_RS00875	COG4206	TonB-dependent receptor
INE90_RS00885	COG4974	Belongs to the 'phage' integrase family
INE90_RS00920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE90_RS00920	COG0551	DNA topoisomerase type I activity
INE90_RS00940	COG0784	Response regulator, receiver
INE90_RS00940	COG2205	protein histidine kinase activity
INE90_RS00940	COG2198	Histidine kinase
INE90_RS00940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE90_RS01060	COG0358	DNA primase activity
INE90_RS01165	COG3507	Belongs to the glycosyl hydrolase 43 family
INE90_RS01170	COG1501	Belongs to the glycosyl hydrolase 31 family
INE90_RS01180	COG3250	beta-galactosidase activity
INE90_RS01185	COG1874	Beta-galactosidase
INE90_RS01190	COG3250	beta-galactosidase activity
INE90_RS01195	COG4948	Mandelate Racemase Muconate Lactonizing
INE90_RS01210	COG0561	phosphatase activity
INE90_RS01215	COG4771	TonB-dependent receptor
INE90_RS01220	COG0745	RESPONSE REGULATOR receiver
INE90_RS01220	COG2205	protein histidine kinase activity
INE90_RS01220	COG3292	Two component regulator propeller
INE90_RS01225	COG3250	beta-galactosidase activity
INE90_RS01235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE90_RS01240	COG1349	DNA-binding transcription factor activity
INE90_RS01245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE90_RS01245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE90_RS01250	COG3959	Transketolase, thiamine diphosphate binding domain
INE90_RS01255	COG3958	Transketolase
INE90_RS01260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INE90_RS01275	COG4771	TonB-dependent receptor
INE90_RS01280	COG0702	epimerase
INE90_RS01290	COG2382	esterase
INE90_RS01295	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS01300	COG0423	glycine-tRNA ligase activity
INE90_RS01310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
INE90_RS01315	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
INE90_RS01335	COG3876	Protein conserved in bacteria
INE90_RS01340	COG2807	transmembrane transport
INE90_RS01370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE90_RS01375	COG3876	Protein conserved in bacteria
INE90_RS01405	COG0702	epimerase
INE90_RS01410	COG4206	TonB-dependent receptor
INE90_RS01410	COG1629	transport
INE90_RS01420	COG4206	TonB-dependent receptor
INE90_RS01420	COG1629	transport
INE90_RS01425	COG0702	epimerase
INE90_RS01430	COG1649	PFAM Uncharacterised BCR, COG1649
INE90_RS01435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INE90_RS01440	COG0589	response to stress
INE90_RS01440	COG0475	glutathione-regulated potassium exporter activity
INE90_RS01445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INE90_RS01450	COG1136	(ABC) transporter
INE90_RS01465	COG0733	neurotransmitter:sodium symporter activity
INE90_RS01475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INE90_RS01480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INE90_RS01485	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
INE90_RS01490	COG0312	modulator of DNA gyrase
INE90_RS01495	COG0312	modulator of DNA gyrase
INE90_RS01510	COG1346	cytolysis
INE90_RS01515	COG1380	Effector of murein hydrolase LrgA
INE90_RS01520	COG0280	phosphate acetyltransferase
INE90_RS01525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INE90_RS01530	COG1785	Belongs to the alkaline phosphatase family
INE90_RS01545	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE90_RS01555	COG2003	Belongs to the UPF0758 family
INE90_RS01560	COG1216	Glycosyl transferase, family 2
INE90_RS01565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INE90_RS01570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
INE90_RS01580	COG0564	pseudouridine synthase activity
INE90_RS01610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INE90_RS01615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
INE90_RS01625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INE90_RS01645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INE90_RS01655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE90_RS01655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INE90_RS01660	COG2890	protein-(glutamine-N5) methyltransferase activity
INE90_RS01670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INE90_RS01700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
INE90_RS01705	COG1917	Cupin 2, conserved barrel domain protein
INE90_RS01705	COG1396	sequence-specific DNA binding
INE90_RS01710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INE90_RS01715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INE90_RS01720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INE90_RS01730	COG0137	argininosuccinate synthase activity
INE90_RS01810	COG2942	2-epimerase
INE90_RS01815	COG4771	TonB-dependent receptor
INE90_RS01820	COG0702	epimerase
INE90_RS01835	COG3250	beta-galactosidase activity
INE90_RS01850	COG4771	TonB-dependent receptor
INE90_RS01890	COG2433	Pfam Transposase IS66
INE90_RS01910	COG1484	DNA-dependent DNA replication
INE90_RS01980	COG3385	transposase activity
INE90_RS02010	COG0039	L-malate dehydrogenase activity
INE90_RS02015	COG2996	Protein conserved in bacteria
INE90_RS02035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE90_RS02040	COG0577	efflux transmembrane transporter activity
INE90_RS02040	COG1136	(ABC) transporter
INE90_RS02045	COG0577	efflux transmembrane transporter activity
INE90_RS02045	COG1136	(ABC) transporter
INE90_RS02050	COG1136	(ABC) transporter
INE90_RS02055	COG1940	carbohydrate kinase activity
INE90_RS02060	COG3328	transposase activity
INE90_RS02065	COG0335	large ribosomal subunit rRNA binding
INE90_RS02070	COG0737	Belongs to the 5'-nucleotidase family
INE90_RS02075	COG0737	Belongs to the 5'-nucleotidase family
INE90_RS02080	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS02085	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS02100	COG4948	Mandelate Racemase Muconate Lactonizing
INE90_RS02105	COG0667	Aldo Keto reductase
INE90_RS02110	COG3459	Glycosyltransferase 36 associated
INE90_RS02115	COG3250	beta-galactosidase activity
INE90_RS02120	COG2207	Transcriptional regulator
INE90_RS02120	COG0662	Cupin 2, conserved barrel domain protein
INE90_RS02125	COG3458	cephalosporin-C deacetylase activity
INE90_RS02155	COG4771	TonB-dependent receptor
INE90_RS02160	COG0561	phosphatase activity
INE90_RS02175	COG4124	Belongs to the glycosyl hydrolase 26 family
INE90_RS02180	COG4206	TonB-dependent receptor
INE90_RS02180	COG1629	transport
INE90_RS02240	COG4124	Belongs to the glycosyl hydrolase 26 family
INE90_RS02245	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE90_RS02250	COG2211	Major facilitator Superfamily
INE90_RS02255	COG2942	2-epimerase
INE90_RS02265	COG0460	homoserine dehydrogenase
INE90_RS02265	COG0527	aspartate kinase activity
INE90_RS02270	COG2204	response regulator
INE90_RS02290	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
INE90_RS02295	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
INE90_RS02300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
INE90_RS02310	COG2205	protein histidine kinase activity
INE90_RS02315	COG5002	protein histidine kinase activity
INE90_RS02320	COG2207	Transcriptional regulator
INE90_RS02320	COG4753	response regulator
INE90_RS02355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INE90_RS02360	COG0436	Aminotransferase
INE90_RS02370	COG2202	Pas domain
INE90_RS02370	COG2205	protein histidine kinase activity
INE90_RS02375	COG2202	Pas domain
INE90_RS02375	COG2205	protein histidine kinase activity
INE90_RS02380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INE90_RS02405	COG0702	epimerase
INE90_RS02410	COG4771	TonB-dependent receptor
INE90_RS02455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE90_RS02460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INE90_RS02465	COG1160	GTP binding
INE90_RS02470	COG1127	ABC transporter
INE90_RS02475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
INE90_RS02485	COG0724	RNA recognition motif
INE90_RS02490	COG0544	peptidyl-prolyl cis-trans isomerase activity
INE90_RS02495	COG0740	serine-type endopeptidase activity
INE90_RS02500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INE90_RS02505	COG0514	ATP-dependent DNA helicase (RecQ)
INE90_RS02510	COG0516	GMP reductase activity
INE90_RS02510	COG0517	IMP dehydrogenase activity
INE90_RS02515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE90_RS02525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INE90_RS02540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INE90_RS02560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE90_RS02565	COG0110	maltose O-acetyltransferase activity
INE90_RS02585	COG1187	pseudouridine synthase activity
INE90_RS02590	COG0017	Asparaginyl-tRNA synthetase
INE90_RS02600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INE90_RS02605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INE90_RS02610	COG0052	Belongs to the universal ribosomal protein uS2 family
INE90_RS02615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INE90_RS02625	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
INE90_RS02630	COG0179	Fumarylacetoacetate (FAA) hydrolase
INE90_RS02640	COG4206	TonB-dependent receptor
INE90_RS02640	COG1629	transport
INE90_RS02655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INE90_RS02660	COG1408	metallophosphoesterase
INE90_RS02665	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS02675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE90_RS02680	COG1629	transport
INE90_RS02680	COG4206	TonB-dependent receptor
INE90_RS02695	COG0673	inositol 2-dehydrogenase activity
INE90_RS02700	COG0673	inositol 2-dehydrogenase activity
INE90_RS02720	COG0482	sulfurtransferase activity
INE90_RS02730	COG1570	exodeoxyribonuclease VII activity
INE90_RS02745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE90_RS02750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INE90_RS02755	COG0489	protein tyrosine kinase activity
INE90_RS02760	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
INE90_RS02770	COG0673	inositol 2-dehydrogenase activity
INE90_RS02775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE90_RS02810	COG0039	L-malate dehydrogenase activity
INE90_RS02830	COG4771	TonB-dependent receptor
INE90_RS02860	COG3250	beta-galactosidase activity
INE90_RS02865	COG4948	Mandelate Racemase Muconate Lactonizing
INE90_RS02875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE90_RS02890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INE90_RS02900	COG0811	peptide transport
INE90_RS02920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INE90_RS02925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INE90_RS02930	COG0739	heme binding
INE90_RS02945	COG0149	triose-phosphate isomerase activity
INE90_RS02955	COG0302	gtp cyclohydrolase
INE90_RS02960	COG0358	DNA primase activity
INE90_RS02970	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
INE90_RS02975	COG0436	Aminotransferase
INE90_RS02995	COG0514	ATP-dependent DNA helicase (RecQ)
INE90_RS03000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INE90_RS03000	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INE90_RS03005	COG3022	response to hydroperoxide
INE90_RS03010	COG0823	Involved in the tonB-independent uptake of proteins
INE90_RS03020	COG1629	transport
INE90_RS03020	COG4206	TonB-dependent receptor
INE90_RS03030	COG3537	Alpha-1,2-mannosidase
INE90_RS03040	COG1785	Belongs to the alkaline phosphatase family
INE90_RS03055	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE90_RS03060	COG5183	chlorophyll binding
INE90_RS03060	COG2133	pyrroloquinoline quinone binding
INE90_RS03065	COG2207	Transcriptional regulator
INE90_RS03065	COG1609	Transcriptional regulator
INE90_RS03075	COG0009	L-threonylcarbamoyladenylate synthase
INE90_RS03085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INE90_RS03090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INE90_RS03095	COG0658	competence protein
INE90_RS03095	COG2333	competence protein COMEC
INE90_RS03100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INE90_RS03110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE90_RS03115	COG1115	amino acid carrier protein
INE90_RS03120	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
INE90_RS03125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE90_RS03135	COG2815	serine threonine protein kinase
INE90_RS03135	COG0515	serine threonine protein kinase
INE90_RS03140	COG0631	protein serine/threonine phosphatase activity
INE90_RS03165	COG2815	serine threonine protein kinase
INE90_RS03165	COG0515	serine threonine protein kinase
INE90_RS03170	COG3275	phosphorelay sensor kinase activity
INE90_RS03175	COG3279	Response regulator of the LytR AlgR family
INE90_RS03180	COG3328	transposase activity
INE90_RS03210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INE90_RS03235	COG1082	Xylose isomerase domain protein TIM barrel
INE90_RS03255	COG3250	beta-galactosidase activity
INE90_RS03260	COG2818	Glycosylase
INE90_RS03280	COG3292	Two component regulator propeller
INE90_RS03280	COG2205	protein histidine kinase activity
INE90_RS03280	COG0745	RESPONSE REGULATOR receiver
INE90_RS03285	COG4206	TonB-dependent receptor
INE90_RS03285	COG1629	transport
INE90_RS03300	COG2818	Glycosylase
INE90_RS03315	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
INE90_RS03320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE90_RS03345	COG0360	Binds together with S18 to 16S ribosomal RNA
INE90_RS03350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INE90_RS03355	COG0359	binds to the 23S rRNA
INE90_RS03360	COG0724	RNA recognition motif
INE90_RS03370	COG0318	PFAM AMP-dependent synthetase and ligase
INE90_RS03375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE90_RS03395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INE90_RS03400	COG1640	4-alpha-glucanotransferase
INE90_RS03410	COG0778	Nitroreductase
INE90_RS03415	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INE90_RS03425	COG0860	N-Acetylmuramoyl-L-alanine amidase
INE90_RS03460	COG0463	Glycosyl transferase, family 2
INE90_RS03470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
INE90_RS03485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INE90_RS03490	COG2502	aspartate--ammonia ligase
INE90_RS03500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INE90_RS03510	COG0789	Transcriptional regulator
INE90_RS03530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE90_RS03535	COG0166	Belongs to the GPI family
INE90_RS03540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INE90_RS03545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INE90_RS03565	COG0569	domain protein
INE90_RS03565	COG2985	domain, Protein
INE90_RS03570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE90_RS03575	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE90_RS03575	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INE90_RS03580	COG0551	DNA topoisomerase type I activity
INE90_RS03580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE90_RS03610	COG3681	Belongs to the UPF0597 family
INE90_RS03615	COG1047	Peptidyl-prolyl cis-trans
INE90_RS03620	COG0129	dihydroxy-acid dehydratase activity
INE90_RS03625	COG0028	Belongs to the TPP enzyme family
INE90_RS03630	COG0440	acetolactate synthase activity
INE90_RS03640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INE90_RS03645	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
INE90_RS03655	COG0538	isocitrate dehydrogenase activity
INE90_RS03660	COG0372	Belongs to the citrate synthase family
INE90_RS03675	COG1028	Short-chain dehydrogenase reductase Sdr
INE90_RS03680	COG0205	6-phosphofructokinase activity
INE90_RS03685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INE90_RS03690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INE90_RS03710	COG0084	hydrolase, TatD family'
INE90_RS03720	COG0811	peptide transport
INE90_RS03750	COG1522	sequence-specific DNA binding
INE90_RS03760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INE90_RS03775	COG1595	DNA-templated transcription, initiation
INE90_RS03790	COG4771	TonB-dependent receptor
INE90_RS03795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
INE90_RS03795	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
INE90_RS03825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE90_RS03830	COG0488	(ABC) transporter
INE90_RS03835	COG2204	response regulator
INE90_RS03845	COG0617	tRNA 3'-terminal CCA addition
INE90_RS03855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INE90_RS03865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INE90_RS03875	COG1575	Belongs to the MenA family. Type 1 subfamily
INE90_RS03880	COG1408	metallophosphoesterase
INE90_RS03890	COG2205	protein histidine kinase activity
INE90_RS03890	COG0745	RESPONSE REGULATOR receiver
INE90_RS03890	COG3292	Two component regulator propeller
INE90_RS03895	COG1940	carbohydrate kinase activity
INE90_RS03900	COG0363	glucosamine-6-phosphate deaminase activity
INE90_RS03915	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS03925	COG4771	TonB-dependent receptor
INE90_RS03970	COG0006	proline dipeptidase activity
INE90_RS03980	COG0632	four-way junction helicase activity
INE90_RS03985	COG0673	inositol 2-dehydrogenase activity
INE90_RS03990	COG0750	zinc metalloprotease
INE90_RS03995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INE90_RS04005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INE90_RS04010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INE90_RS04020	COG1214	PFAM Peptidase M22, glycoprotease
INE90_RS04030	COG0194	GDP metabolic process
INE90_RS04040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INE90_RS04045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE90_RS04050	COG0523	cobalamin synthesis protein
INE90_RS04055	COG2188	Transcriptional regulator
INE90_RS04065	COG1940	carbohydrate kinase activity
INE90_RS04075	COG3537	Alpha-1,2-mannosidase
INE90_RS04080	COG3119	arylsulfatase activity
INE90_RS04095	COG4771	TonB-dependent receptor
INE90_RS04100	COG0702	epimerase
INE90_RS04115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INE90_RS04130	COG2873	o-acetylhomoserine
INE90_RS04145	COG1917	Cupin 2, conserved barrel domain protein
INE90_RS04145	COG2207	Transcriptional regulator
INE90_RS04160	COG1733	regulation of RNA biosynthetic process
INE90_RS04175	COG0471	metal ion transport
INE90_RS04175	COG0490	domain, Protein
INE90_RS04190	COG1595	DNA-templated transcription, initiation
INE90_RS04195	COG1629	transport
INE90_RS04195	COG4206	TonB-dependent receptor
INE90_RS04210	COG4948	Mandelate Racemase Muconate Lactonizing
INE90_RS04225	COG3328	transposase activity
INE90_RS04235	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS04240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE90_RS04275	COG4948	Mandelate Racemase Muconate Lactonizing
INE90_RS04285	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE90_RS04295	COG1136	(ABC) transporter
INE90_RS04315	COG2211	Major facilitator Superfamily
INE90_RS04320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE90_RS04370	COG1674	ftsk spoiiie
INE90_RS04380	COG0492	ferredoxin-NADP+ reductase activity
INE90_RS04425	COG1595	DNA-templated transcription, initiation
INE90_RS04440	COG3956	TIGRFAM MazG family protein
INE90_RS04450	COG0525	valine-tRNA ligase activity
INE90_RS04480	COG4974	Belongs to the 'phage' integrase family
INE90_RS04560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE90_RS04570	COG0489	protein tyrosine kinase activity
INE90_RS04570	COG3206	protein involved in exopolysaccharide biosynthesis
INE90_RS04595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INE90_RS04610	COG0438	transferase activity, transferring glycosyl groups
INE90_RS04655	COG0110	maltose O-acetyltransferase activity
INE90_RS04665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INE90_RS04670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE90_RS04685	COG1629	transport
INE90_RS04690	COG0561	phosphatase activity
INE90_RS04710	COG3328	transposase activity
INE90_RS04725	COG0653	protein targeting
INE90_RS04730	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
INE90_RS04760	COG1253	flavin adenine dinucleotide binding
INE90_RS04770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INE90_RS04780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
INE90_RS04820	COG2706	6-phosphogluconolactonase activity
INE90_RS04825	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS04855	COG2217	Heavy metal translocating P-type atpase
INE90_RS04870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE90_RS04875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
INE90_RS04880	COG0534	Mate efflux family protein
INE90_RS05005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INE90_RS05010	COG1410	methionine synthase
INE90_RS05010	COG0646	methionine synthase
INE90_RS05015	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE90_RS05020	COG0572	uridine kinase
INE90_RS05030	COG4232	protein-disulfide reductase activity
INE90_RS05040	COG1595	DNA-templated transcription, initiation
INE90_RS05050	COG4771	TonB-dependent receptor
INE90_RS05090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INE90_RS05095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INE90_RS05100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE90_RS05105	COG0131	Imidazoleglycerol-phosphate dehydratase
INE90_RS05110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE90_RS05110	COG4651	solute:proton antiporter activity
INE90_RS05115	COG0673	inositol 2-dehydrogenase activity
INE90_RS05120	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INE90_RS05125	COG0193	aminoacyl-tRNA hydrolase activity
INE90_RS05130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INE90_RS05140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INE90_RS05145	COG1862	Preprotein translocase
INE90_RS05155	COG0237	dephospho-CoA kinase activity
INE90_RS05165	COG0542	response to heat
INE90_RS05175	COG0583	DNA-binding transcription factor activity
INE90_RS05180	COG2855	membrane
INE90_RS05200	COG1595	DNA-templated transcription, initiation
INE90_RS05215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INE90_RS05220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
INE90_RS05245	COG0443	Heat shock 70 kDa protein
INE90_RS05255	COG4974	Belongs to the 'phage' integrase family
INE90_RS05295	COG3328	transposase activity
INE90_RS05300	COG0582	viral genome integration into host DNA
INE90_RS05305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE90_RS05320	COG3328	transposase activity
INE90_RS05330	COG0514	ATP-dependent DNA helicase (RecQ)
INE90_RS05335	COG0561	phosphatase activity
INE90_RS05355	COG4139	cobalamin transport
INE90_RS05390	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
INE90_RS05395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE90_RS05440	COG0745	RESPONSE REGULATOR receiver
INE90_RS05445	COG5002	protein histidine kinase activity
INE90_RS05445	COG3850	Histidine kinase
INE90_RS05460	COG1760	l-serine dehydratase
INE90_RS05465	COG1193	negative regulation of DNA recombination
INE90_RS05480	COG1484	DNA-dependent DNA replication
INE90_RS05725	COG3392	D12 class N6 adenine-specific DNA methyltransferase
INE90_RS05805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INE90_RS05835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE90_RS05845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INE90_RS05860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INE90_RS05865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INE90_RS05870	COG3119	arylsulfatase activity
INE90_RS05885	COG0037	tRNA processing
INE90_RS05890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INE90_RS05890	COG1918	ferrous iron import across plasma membrane
INE90_RS05915	COG0346	lactoylglutathione lyase activity
INE90_RS05930	COG1741	Belongs to the pirin family
INE90_RS05935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE90_RS05960	COG0702	epimerase
INE90_RS05965	COG4206	TonB-dependent receptor
INE90_RS05965	COG1629	transport
INE90_RS05975	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
INE90_RS05980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
INE90_RS05985	COG0148	phosphopyruvate hydratase activity
INE90_RS06010	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
INE90_RS06020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE90_RS06040	COG1151	hydroxylamine reductase activity
INE90_RS06055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
INE90_RS06090	COG0714	Associated with various cellular activities
INE90_RS06100	COG2207	Transcriptional regulator
INE90_RS06100	COG1609	Transcriptional regulator
INE90_RS06105	COG0561	phosphatase activity
INE90_RS06280	COG1690	Belongs to the RtcB family
INE90_RS06620	COG0489	protein tyrosine kinase activity
INE90_RS06625	COG4974	Belongs to the 'phage' integrase family
INE90_RS06630	COG4974	Belongs to the 'phage' integrase family
INE90_RS06640	COG0788	formyltetrahydrofolate deformylase activity
INE90_RS06645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INE90_RS06650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INE90_RS06655	COG0107	imidazoleglycerol-phosphate synthase activity
INE90_RS06660	COG0140	phosphoribosyl-ATP diphosphatase activity
INE90_RS06660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INE90_RS06665	COG2884	Cell division ATP-binding protein ftsE
INE90_RS06670	COG0527	aspartate kinase activity
INE90_RS06675	COG0019	diaminopimelate decarboxylase activity
INE90_RS06685	COG0156	8-amino-7-oxononanoate synthase activity
INE90_RS06705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE90_RS06705	COG0321	lipoyl(octanoyl) transferase activity
INE90_RS06720	COG0592	DNA-directed DNA polymerase activity
INE90_RS06735	COG0497	DNA recombination
INE90_RS06740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE90_RS06760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
INE90_RS06770	COG0167	dihydroorotate dehydrogenase activity
INE90_RS06775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INE90_RS06810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE90_RS06815	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INE90_RS06825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE90_RS06845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE90_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
INE90_RS06855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INE90_RS06860	COG0318	PFAM AMP-dependent synthetase and ligase
INE90_RS06865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE90_RS06890	COG0656	L-ascorbic acid biosynthetic process
INE90_RS06895	COG1234	tRNA 3'-trailer cleavage
INE90_RS06915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE90_RS06930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
INE90_RS06935	COG0586	Pfam SNARE associated Golgi protein
INE90_RS06945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE90_RS06950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INE90_RS06955	COG0573	inorganic phosphate transmembrane transporter activity
INE90_RS06960	COG0581	inorganic phosphate transmembrane transporter activity
INE90_RS06965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INE90_RS06970	COG0704	Plays a role in the regulation of phosphate uptake
INE90_RS07000	COG4948	Mandelate Racemase Muconate Lactonizing
INE90_RS07010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INE90_RS07015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INE90_RS07045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
INE90_RS07070	COG1595	DNA-templated transcription, initiation
INE90_RS07095	COG0531	amino acid
INE90_RS07105	COG2066	Belongs to the glutaminase family
INE90_RS07110	COG0076	glutamate decarboxylase activity
INE90_RS07120	COG0686	Belongs to the AlaDH PNT family
INE90_RS07125	COG0739	heme binding
INE90_RS07135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INE90_RS07175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INE90_RS07180	COG0488	(ABC) transporter
INE90_RS07185	COG0295	cytidine deaminase activity
INE90_RS07190	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE90_RS07195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE90_RS07200	COG0577	efflux transmembrane transporter activity
INE90_RS07210	COG1136	(ABC) transporter
INE90_RS07215	COG1136	(ABC) transporter
INE90_RS07215	COG0577	efflux transmembrane transporter activity
INE90_RS07230	COG0577	efflux transmembrane transporter activity
INE90_RS07250	COG0784	Response regulator, receiver
INE90_RS07250	COG2205	protein histidine kinase activity
INE90_RS07260	COG0436	Aminotransferase
INE90_RS07265	COG4591	ABC-type transport system involved in lipoprotein release permease component
INE90_RS07270	COG1215	transferase activity, transferring glycosyl groups
INE90_RS07280	COG2226	methyltransferase
INE90_RS07295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
INE90_RS07295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE90_RS07325	COG0305	Participates in initiation and elongation during chromosome replication
INE90_RS07670	COG1131	(ABC) transporter
INE90_RS07690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
INE90_RS07715	COG0702	epimerase
INE90_RS07720	COG1629	transport
INE90_RS07725	COG0745	RESPONSE REGULATOR receiver
INE90_RS07725	COG2205	protein histidine kinase activity
INE90_RS07725	COG0745	RESPONSE REGULATOR receiver
INE90_RS07725	COG3292	Two component regulator propeller
INE90_RS07725	COG2205	protein histidine kinase activity
INE90_RS07725	COG3292	Two component regulator propeller
INE90_RS07740	COG0564	pseudouridine synthase activity
INE90_RS07745	COG0823	Involved in the tonB-independent uptake of proteins
INE90_RS07745	COG1506	peptidase
INE90_RS07755	COG2204	response regulator
INE90_RS07760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INE90_RS07765	COG0612	Peptidase, M16
INE90_RS07770	COG0534	Mate efflux family protein
INE90_RS07775	COG0784	Response regulator, receiver
INE90_RS07775	COG2205	protein histidine kinase activity
INE90_RS07795	COG1132	(ABC) transporter
INE90_RS07855	COG2205	protein histidine kinase activity
INE90_RS07855	COG0784	Response regulator, receiver
INE90_RS07860	COG0488	(ABC) transporter
INE90_RS07865	COG3590	peptidase
INE90_RS07870	COG0138	bifunctional purine biosynthesis protein purh
INE90_RS07880	COG1792	Involved in formation and maintenance of cell shape
INE90_RS07895	COG0772	Belongs to the SEDS family
INE90_RS07905	COG1774	PSP1 C-terminal conserved region
INE90_RS07910	COG0470	DNA polymerase III
INE90_RS07915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INE90_RS07930	COG0826	peptidase U32
INE90_RS07945	COG1487	ribonuclease activity
INE90_RS07950	COG4771	TonB-dependent receptor
INE90_RS07965	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
INE90_RS07970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INE90_RS07975	COG0288	reversible hydration of carbon dioxide
INE90_RS07980	COG0252	asparaginase activity
INE90_RS07985	COG0527	aspartate kinase activity
INE90_RS07985	COG0460	homoserine dehydrogenase
INE90_RS07990	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
INE90_RS07995	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INE90_RS08070	COG0456	acetyltransferase
INE90_RS08090	COG0628	permease
INE90_RS08095	COG1435	thymidine kinase activity
INE90_RS08105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE90_RS08120	COG2095	MarC family integral membrane protein
INE90_RS08130	COG1629	transport
INE90_RS08130	COG4206	TonB-dependent receptor
INE90_RS08145	COG1373	ATPase (AAA superfamily
INE90_RS08155	COG1629	transport
INE90_RS08155	COG4206	TonB-dependent receptor
INE90_RS08165	COG1629	transport
INE90_RS08165	COG4206	TonB-dependent receptor
INE90_RS08170	COG1373	ATPase (AAA superfamily
INE90_RS08185	COG4771	TonB-dependent receptor
INE90_RS08190	COG4974	Belongs to the 'phage' integrase family
INE90_RS08195	COG1629	transport
INE90_RS08195	COG4206	TonB-dependent receptor
INE90_RS08210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INE90_RS08220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INE90_RS08220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INE90_RS08225	COG0531	amino acid
INE90_RS08235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE90_RS08240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE90_RS08245	COG1162	GTPase activity
INE90_RS08250	COG0233	cytoplasmic translational termination
INE90_RS08255	COG0528	UMP kinase activity
INE90_RS08265	COG0697	spore germination
INE90_RS08270	COG2217	Heavy metal translocating P-type atpase
INE90_RS08275	COG0534	Mate efflux family protein
INE90_RS08285	COG2205	protein histidine kinase activity
INE90_RS08285	COG0745	RESPONSE REGULATOR receiver
INE90_RS08285	COG3292	Two component regulator propeller
INE90_RS08295	COG4771	TonB-dependent receptor
INE90_RS08300	COG0702	epimerase
INE90_RS08310	COG3250	beta-galactosidase activity
INE90_RS08325	COG0792	nuclease activity
INE90_RS08350	COG1183	phosphatidylcholine synthase activity
INE90_RS08355	COG0688	phosphatidylethanolamine metabolic process
INE90_RS08385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INE90_RS08395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INE90_RS08405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INE90_RS08415	COG0490	domain, Protein
INE90_RS08415	COG2985	domain, Protein
INE90_RS08420	COG0823	Involved in the tonB-independent uptake of proteins
INE90_RS08420	COG1506	peptidase
INE90_RS08420	COG4946	Tricorn protease homolog
INE90_RS08445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INE90_RS08460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INE90_RS08465	COG0742	ribosomal rna small subunit methyltransferase
INE90_RS08495	COG0739	heme binding
INE90_RS08510	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE90_RS08510	COG1388	LysM domain
INE90_RS08520	COG1475	DNA binding
INE90_RS08525	COG1192	Involved in chromosome partitioning
INE90_RS08540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
INE90_RS08545	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE90_RS08560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INE90_RS08575	COG0138	bifunctional purine biosynthesis protein purh
INE90_RS08580	COG1196	nuclear chromosome segregation
INE90_RS08585	COG2239	Acts as a magnesium transporter
INE90_RS08590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INE90_RS08600	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE90_RS08630	COG1119	ATPase activity
INE90_RS08640	COG0668	transmembrane transport
INE90_RS08655	COG1404	Belongs to the peptidase S8 family
INE90_RS08655	COG4412	M6 family metalloprotease domain protein
INE90_RS08660	COG0784	Response regulator, receiver
INE90_RS08660	COG2205	protein histidine kinase activity
INE90_RS08660	COG5002	protein histidine kinase activity
INE90_RS08670	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE90_RS08675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INE90_RS08680	COG0713	ATP synthesis coupled electron transport
INE90_RS08685	COG0839	Belongs to the complex I subunit 6 family
INE90_RS08690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE90_RS08695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INE90_RS08700	COG0649	NAD binding
INE90_RS08700	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE90_RS08705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE90_RS08710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INE90_RS08720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INE90_RS08725	COG0569	domain protein
INE90_RS08730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INE90_RS08750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INE90_RS08755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INE90_RS08760	COG0805	protein transport
INE90_RS08775	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
INE90_RS08780	COG3775	system Galactitol-specific IIC component
INE90_RS08795	COG4771	TonB-dependent receptor
INE90_RS08810	COG0546	phosphoglycolate phosphatase activity
INE90_RS08815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
INE90_RS08820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INE90_RS08830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INE90_RS08835	COG1506	peptidase
INE90_RS08835	COG0823	Involved in the tonB-independent uptake of proteins
INE90_RS08840	COG4821	SIS domain
INE90_RS08845	COG2814	Major facilitator Superfamily
INE90_RS08855	COG1242	4 iron, 4 sulfur cluster binding
INE90_RS08865	COG0363	glucosamine-6-phosphate deaminase activity
INE90_RS08910	COG0681	Belongs to the peptidase S26 family
INE90_RS09045	COG4974	Belongs to the 'phage' integrase family
INE90_RS09050	COG4974	Belongs to the 'phage' integrase family
INE90_RS09075	COG0628	permease
INE90_RS09080	COG0009	L-threonylcarbamoyladenylate synthase
INE90_RS09085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE90_RS09090	COG0561	phosphatase activity
INE90_RS09105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE90_RS09120	COG5297	Belongs to the glycosyl hydrolase family 6
INE90_RS09120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE90_RS09125	COG2205	protein histidine kinase activity
INE90_RS09125	COG3292	Two component regulator propeller
INE90_RS09125	COG0745	RESPONSE REGULATOR receiver
INE90_RS09125	COG0745	RESPONSE REGULATOR receiver
INE90_RS09125	COG2205	protein histidine kinase activity
INE90_RS09125	COG3292	Two component regulator propeller
INE90_RS09130	COG4206	TonB-dependent receptor
INE90_RS09130	COG1629	transport
INE90_RS09145	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS09150	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS09160	COG1073	alpha beta
INE90_RS09180	COG3487	Iron-regulated protein
INE90_RS09205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INE90_RS09205	COG1333	cytochrome c biogenesis protein
INE90_RS09230	COG4206	TonB-dependent receptor
INE90_RS09230	COG1629	transport
INE90_RS09435	COG0456	acetyltransferase
INE90_RS09435	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
INE90_RS09465	COG1538	Outer membrane efflux protein
INE90_RS09495	COG0739	heme binding
INE90_RS09565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE90_RS09570	COG1705	Flagellar rod assembly protein muramidase FlgJ
INE90_RS09600	COG1373	ATPase (AAA superfamily
INE90_RS09655	COG3118	belongs to the thioredoxin family
INE90_RS09710	COG1192	Involved in chromosome partitioning
INE90_RS09715	COG0629	single-stranded DNA binding
INE90_RS09770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE90_RS09780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE90_RS09785	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
INE90_RS09785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INE90_RS09790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE90_RS09795	COG1078	dGTPase activity
INE90_RS09800	COG0284	orotidine-5'-phosphate decarboxylase activity
INE90_RS09805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INE90_RS09810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INE90_RS09815	COG1704	LemA family
INE90_RS09830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INE90_RS09840	COG2226	methyltransferase
INE90_RS09845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INE90_RS09850	COG1702	phosphate starvation-inducible protein PhoH
INE90_RS09865	COG1496	oxidoreductase activity
INE90_RS09870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE90_RS09875	COG0563	adenylate kinase activity
INE90_RS09880	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INE90_RS09890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
INE90_RS09890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INE90_RS09905	COG0101	tRNA pseudouridine synthase activity
INE90_RS09915	COG1956	GAF domain-containing protein
INE90_RS09925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE90_RS09935	COG2755	lipolytic protein G-D-S-L family
INE90_RS09935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE90_RS09960	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
INE90_RS09985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INE90_RS09990	COG0793	Belongs to the peptidase S41A family
INE90_RS09995	COG2131	deaminase
INE90_RS10005	COG0339	signal peptide processing
INE90_RS10015	COG1970	mechanosensitive ion channel activity
INE90_RS10020	COG0519	Catalyzes the synthesis of GMP from XMP
INE90_RS10020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INE90_RS10025	COG0519	Catalyzes the synthesis of GMP from XMP
INE90_RS10050	COG0438	transferase activity, transferring glycosyl groups
INE90_RS10065	COG0297	glycogen (starch) synthase activity
INE90_RS10070	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INE90_RS10075	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INE90_RS10085	COG0543	2 iron, 2 sulfur cluster binding
INE90_RS10170	COG3279	Response regulator of the LytR AlgR family
INE90_RS10175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INE90_RS10180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INE90_RS10185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INE90_RS10200	COG1191	sigma factor activity
INE90_RS10210	COG3537	Alpha-1,2-mannosidase
INE90_RS10215	COG4771	TonB-dependent receptor
INE90_RS10240	COG3537	Alpha-1,2-mannosidase
INE90_RS10250	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INE90_RS10255	COG3537	Alpha-1,2-mannosidase
INE90_RS10270	COG0791	NLP P60 protein
INE90_RS10285	COG0612	Peptidase, M16
INE90_RS10290	COG2877	3-deoxy-8-phosphooctulonate synthase activity
INE90_RS10295	COG1597	lipid kinase activity
INE90_RS10300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INE90_RS10305	COG0534	Mate efflux family protein
INE90_RS10315	COG3973	AAA domain
INE90_RS10410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE90_RS10410	COG0551	DNA topoisomerase type I activity
INE90_RS10435	COG0784	Response regulator, receiver
INE90_RS10435	COG2205	protein histidine kinase activity
INE90_RS10445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INE90_RS10490	COG4104	PAAR repeat-containing protein
INE90_RS10490	COG3209	COG3209 Rhs family protein
INE90_RS10555	COG0542	response to heat
INE90_RS10675	COG1192	Involved in chromosome partitioning
INE90_RS10880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
INE90_RS10885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
INE90_RS10890	COG1663	tetraacyldisaccharide 4'-kinase activity
INE90_RS10895	COG0616	signal peptide processing
INE90_RS10930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INE90_RS10935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INE90_RS10940	COG0066	3-isopropylmalate dehydratase activity
INE90_RS10960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INE90_RS10970	COG0514	ATP-dependent DNA helicase (RecQ)
INE90_RS10990	COG0735	belongs to the Fur family
INE90_RS10995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INE90_RS11015	COG0124	histidyl-tRNA synthetase
INE90_RS11035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INE90_RS11040	COG0459	protein refolding
INE90_RS11060	COG0484	heat shock protein binding
INE90_RS11080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INE90_RS11085	COG2086	electron transfer activity
INE90_RS11105	COG4771	TonB-dependent receptor
INE90_RS11115	COG1621	beta-fructofuranosidase activity
INE90_RS11120	COG1621	beta-fructofuranosidase activity
INE90_RS11130	COG1621	beta-fructofuranosidase activity
INE90_RS11135	COG1621	beta-fructofuranosidase activity
INE90_RS11150	COG3292	Two component regulator propeller
INE90_RS11150	COG2205	protein histidine kinase activity
INE90_RS11150	COG0745	RESPONSE REGULATOR receiver
INE90_RS11175	COG1649	PFAM Uncharacterised BCR, COG1649
INE90_RS11180	COG1966	Carbon starvation protein
INE90_RS11215	COG5002	protein histidine kinase activity
INE90_RS11215	COG0784	Response regulator, receiver
INE90_RS11220	COG1649	PFAM Uncharacterised BCR, COG1649
INE90_RS11235	COG3292	Two component regulator propeller
INE90_RS11235	COG0745	RESPONSE REGULATOR receiver
INE90_RS11235	COG2205	protein histidine kinase activity
INE90_RS11245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE90_RS11250	COG1280	lysine exporter protein (LysE YggA)
INE90_RS11265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
INE90_RS11280	COG0511	ligase activity, forming carbon-carbon bonds
INE90_RS11295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INE90_RS11300	COG1566	PFAM secretion protein HlyD family protein
INE90_RS11305	COG1554	hydrolase, family 65, central catalytic
INE90_RS11315	COG1609	Transcriptional regulator
INE90_RS11325	COG3250	beta-galactosidase activity
INE90_RS11330	COG4206	TonB-dependent receptor
INE90_RS11330	COG1629	transport
INE90_RS11335	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INE90_RS11360	COG0778	Nitroreductase
INE90_RS11375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
INE90_RS11380	COG0424	maF-like protein
INE90_RS11395	COG0126	phosphoglycerate kinase activity
INE90_RS11400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INE90_RS11410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INE90_RS11420	COG1629	transport
INE90_RS11430	COG2223	nitrite transmembrane transporter activity
INE90_RS11450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INE90_RS11455	COG1523	belongs to the glycosyl hydrolase 13 family
INE90_RS11460	COG1119	ATPase activity
INE90_RS11475	COG0671	phosphoesterase, PA-phosphatase related
INE90_RS11495	COG0745	RESPONSE REGULATOR receiver
INE90_RS11500	COG0668	transmembrane transport
INE90_RS11510	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE90_RS11525	COG3142	Participates in the control of copper homeostasis
INE90_RS11530	COG1418	mRNA catabolic process
INE90_RS11560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE90_RS11565	COG2832	Protein of unknown function (DUF454)
INE90_RS11570	COG0351	phosphomethylpyrimidine kinase
INE90_RS11585	COG0602	queuosine metabolic process
INE90_RS11600	COG1509	lysine 2,3-aminomutase activity
INE90_RS11610	COG1115	amino acid carrier protein
INE90_RS11635	COG1285	pathogenesis
INE90_RS11640	COG1388	LysM domain
INE90_RS11640	COG0741	lytic transglycosylase activity
INE90_RS11700	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
INE90_RS11710	COG1247	-acetyltransferase
INE90_RS11715	COG0564	pseudouridine synthase activity
INE90_RS11720	COG5002	protein histidine kinase activity
INE90_RS11720	COG2205	protein histidine kinase activity
INE90_RS11720	COG0784	Response regulator, receiver
INE90_RS11730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
INE90_RS11735	COG0542	response to heat
INE90_RS11740	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
INE90_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
INE90_RS11770	COG1253	flavin adenine dinucleotide binding
INE90_RS11810	COG1757	Na H antiporter
INE90_RS11815	COG2814	Major facilitator Superfamily
INE90_RS11820	COG0745	RESPONSE REGULATOR receiver
INE90_RS11830	COG0813	purine-nucleoside phosphorylase activity
INE90_RS11835	COG4864	UPF0365 protein
INE90_RS11850	COG0037	tRNA processing
INE90_RS11860	COG1477	protein flavinylation
INE90_RS11865	COG1971	Probably functions as a manganese efflux pump
INE90_RS11880	COG0463	Glycosyl transferase, family 2
INE90_RS11900	COG1629	transport
INE90_RS11900	COG4206	TonB-dependent receptor
INE90_RS11905	COG0702	epimerase
INE90_RS11930	COG0148	phosphopyruvate hydratase activity
INE90_RS11940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INE90_RS11950	COG1082	Xylose isomerase domain protein TIM barrel
INE90_RS12085	COG0740	serine-type endopeptidase activity
INE90_RS12175	COG3392	D12 class N6 adenine-specific DNA methyltransferase
INE90_RS12190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INE90_RS12195	COG2195	Cleaves the N-terminal amino acid of tripeptides
INE90_RS12200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
INE90_RS12210	COG0254	rRNA binding
INE90_RS12220	COG0191	fructose-bisphosphate aldolase activity
INE90_RS12225	COG0366	Alpha amylase catalytic
INE90_RS12235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
INE90_RS12240	COG0511	ligase activity, forming carbon-carbon bonds
INE90_RS12250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE90_RS12265	COG2204	response regulator
INE90_RS12270	COG4191	Histidine kinase
INE90_RS12305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INE90_RS12315	COG1979	alcohol dehydrogenase
INE90_RS12320	COG1530	ribonuclease E activity
INE90_RS12325	COG0776	regulation of translation
INE90_RS12335	COG0629	single-stranded DNA binding
INE90_RS12350	COG3033	Beta-eliminating lyase
INE90_RS12355	COG5002	protein histidine kinase activity
INE90_RS12360	COG0745	RESPONSE REGULATOR receiver
INE90_RS12370	COG4771	TonB-dependent receptor
INE90_RS12390	COG0488	(ABC) transporter
INE90_RS12410	COG3591	Belongs to the peptidase S1B family
INE90_RS12415	COG3591	Belongs to the peptidase S1B family
INE90_RS12420	COG0641	radical SAM
INE90_RS12435	COG1408	metallophosphoesterase
INE90_RS12450	COG0646	methionine synthase
INE90_RS12450	COG1410	methionine synthase
INE90_RS12455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INE90_RS12460	COG0463	Glycosyl transferase, family 2
INE90_RS12465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INE90_RS12475	COG1032	radical SAM domain protein
INE90_RS12500	COG0363	glucosamine-6-phosphate deaminase activity
INE90_RS12510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE90_RS12555	COG3757	hydrolase, family 25
INE90_RS12560	COG2264	protein methyltransferase activity
INE90_RS12595	COG1592	Rubrerythrin
INE90_RS12595	COG1773	rubredoxin
INE90_RS12605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INE90_RS12605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE90_RS12610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INE90_RS12620	COG0582	viral genome integration into host DNA
INE90_RS12665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INE90_RS12680	COG0784	Response regulator, receiver
INE90_RS12680	COG2205	protein histidine kinase activity
INE90_RS12680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE90_RS12680	COG2198	Histidine kinase
INE90_RS12720	COG0698	ribose 5-phosphate isomerase
INE90_RS12735	COG1070	Carbohydrate kinase
INE90_RS12740	COG2160	L-arabinose isomerase activity
INE90_RS12765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INE90_RS12780	COG1482	cell wall glycoprotein biosynthetic process
INE90_RS12800	COG0513	Belongs to the DEAD box helicase family
INE90_RS12815	COG1218	3'(2'),5'-bisphosphate nucleotidase
INE90_RS12820	COG0471	metal ion transport
INE90_RS12820	COG3273	potassium ion transport
INE90_RS12825	COG0529	Catalyzes the synthesis of activated sulfate
INE90_RS12830	COG0175	sulfate reduction
INE90_RS12835	COG2895	sulfate adenylyltransferase (ATP) activity
INE90_RS12875	COG4974	Belongs to the 'phage' integrase family
INE90_RS12880	COG2433	Pfam Transposase IS66
INE90_RS12895	COG4974	Belongs to the 'phage' integrase family
INE90_RS12935	COG2223	nitrite transmembrane transporter activity
INE90_RS12980	COG1484	DNA-dependent DNA replication
INE90_RS12985	COG2205	protein histidine kinase activity
INE90_RS12985	COG2198	Histidine kinase
INE90_RS12985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE90_RS12985	COG0784	Response regulator, receiver
INE90_RS13035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INE90_RS13040	COG0242	peptide deformylase activity
INE90_RS13050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INE90_RS13055	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INE90_RS13060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INE90_RS13065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INE90_RS13070	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE90_RS13075	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INE90_RS13075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
INE90_RS13075	COG1013	pyruvate-flavodoxin oxidoreductase activity
INE90_RS13075	COG0674	pyruvate-flavodoxin oxidoreductase activity
INE90_RS13085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INE90_RS13090	COG0823	Involved in the tonB-independent uptake of proteins
INE90_RS13135	COG1940	carbohydrate kinase activity
INE90_RS13155	COG2814	Major facilitator Superfamily
INE90_RS13160	COG2942	2-epimerase
INE90_RS13165	COG4771	TonB-dependent receptor
INE90_RS13170	COG0702	epimerase
INE90_RS13185	COG0457	Tetratricopeptide repeat
INE90_RS13195	COG0484	heat shock protein binding
INE90_RS13200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INE90_RS13205	COG0488	(ABC) transporter
INE90_RS13220	COG2183	response to ionizing radiation
INE90_RS13245	COG4771	TonB-dependent receptor
INE90_RS13250	COG4977	sequence-specific DNA binding
INE90_RS13250	COG1917	Cupin 2, conserved barrel domain protein
INE90_RS13280	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INE90_RS13285	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
INE90_RS13290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE90_RS13295	COG0438	transferase activity, transferring glycosyl groups
INE90_RS13310	COG1215	transferase activity, transferring glycosyl groups
INE90_RS13320	COG1045	serine acetyltransferase
INE90_RS13365	COG1045	serine acetyltransferase
INE90_RS13460	COG0534	Mate efflux family protein
INE90_RS13485	COG0586	Pfam SNARE associated Golgi protein
INE90_RS13495	COG0306	phosphate transporter
INE90_RS13505	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
INE90_RS13515	COG3119	arylsulfatase activity
INE90_RS13520	COG0318	PFAM AMP-dependent synthetase and ligase
INE90_RS13530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE90_RS13540	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
INE90_RS13545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INE90_RS13550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INE90_RS13555	COG0363	glucosamine-6-phosphate deaminase activity
INE90_RS13565	COG0259	pyridoxamine-phosphate oxidase activity
INE90_RS13695	COG0863	Belongs to the N(4) N(6)-methyltransferase family
INE90_RS13750	COG2433	Pfam Transposase IS66
INE90_RS13765	COG3328	transposase activity
INE90_RS13830	COG0740	serine-type endopeptidase activity
INE90_RS13915	COG3328	transposase activity
INE90_RS13920	COG3969	phosphoadenosine phosphosulfate
INE90_RS13935	COG0322	excinuclease ABC activity
INE90_RS13975	COG3279	Response regulator of the LytR AlgR family
INE90_RS13985	COG1136	(ABC) transporter
INE90_RS13985	COG0577	efflux transmembrane transporter activity
INE90_RS13990	COG1136	(ABC) transporter
INE90_RS14020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INE90_RS14030	COG0534	Mate efflux family protein
INE90_RS14040	COG1177	transmembrane transport
INE90_RS14045	COG1176	ABC-type spermidine putrescine transport system, permease component I
INE90_RS14050	COG3842	ATPase activity
INE90_RS14055	COG4221	oxidoreductase activity
INE90_RS14070	COG0488	(ABC) transporter
INE90_RS14090	COG0513	Belongs to the DEAD box helicase family
INE90_RS14095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INE90_RS14100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE90_RS14130	COG0545	Peptidyl-prolyl cis-trans isomerase
INE90_RS14140	COG3328	transposase activity
INE90_RS14145	COG0534	Mate efflux family protein
INE90_RS14150	COG1929	Belongs to the glycerate kinase type-1 family
INE90_RS14155	COG0110	maltose O-acetyltransferase activity
INE90_RS14160	COG1917	Cupin 2, conserved barrel domain protein
INE90_RS14160	COG2207	Transcriptional regulator
INE90_RS14165	COG1739	Uncharacterized protein family UPF0029
INE90_RS14270	COG3392	D12 class N6 adenine-specific DNA methyltransferase
INE90_RS14415	COG1725	Transcriptional regulator
INE90_RS14425	COG1131	(ABC) transporter
INE90_RS14435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE90_RS14435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INE90_RS14440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INE90_RS14445	COG0357	Ribosomal RNA small subunit methyltransferase G
INE90_RS14470	COG2217	Heavy metal translocating P-type atpase
INE90_RS14480	COG0321	lipoyl(octanoyl) transferase activity
INE90_RS14555	COG1086	Polysaccharide biosynthesis protein
INE90_RS14570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
INE90_RS14590	COG0494	nUDIX hydrolase
INE90_RS14595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE90_RS14630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
INE90_RS14645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE90_RS14670	COG1216	Glycosyl transferase, family 2
INE90_RS14680	COG1028	Short-chain dehydrogenase reductase Sdr
INE90_RS14685	COG2089	acid synthase
INE90_RS14695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INE90_RS14700	COG0318	PFAM AMP-dependent synthetase and ligase
INE90_RS14720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE90_RS14735	COG0110	maltose O-acetyltransferase activity
INE90_RS14750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE90_RS14770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE90_RS14770	COG0072	phenylalanine-tRNA ligase activity
INE90_RS14775	COG0217	transcriptional regulatory protein
INE90_RS14785	COG1914	H( )-stimulated, divalent metal cation uptake system
INE90_RS14790	COG0708	Exodeoxyribonuclease III
INE90_RS14805	COG0481	GTPase activity
INE90_RS14810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INE90_RS14815	COG5002	protein histidine kinase activity
INE90_RS14830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INE90_RS14835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INE90_RS14855	COG0612	Peptidase, M16
INE90_RS14870	COG2205	protein histidine kinase activity
INE90_RS14870	COG0784	Response regulator, receiver
INE90_RS14890	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE90_RS14895	COG1805	sodium ion transport
INE90_RS14900	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE90_RS14910	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INE90_RS14925	COG0024	Methionine aminopeptidase
INE90_RS14935	COG0420	3'-5' exonuclease activity
INE90_RS14960	COG2814	Major facilitator Superfamily
INE90_RS14975	COG0564	pseudouridine synthase activity
INE90_RS14980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INE90_RS14985	COG0574	Belongs to the PEP-utilizing enzyme family
INE90_RS14985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INE90_RS14990	COG5002	protein histidine kinase activity
INE90_RS14990	COG2205	protein histidine kinase activity
INE90_RS14990	COG0784	Response regulator, receiver
INE90_RS14995	COG0352	thiamine-phosphate diphosphorylase activity
INE90_RS15055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INE90_RS15070	COG1678	Uncharacterized ACR, COG1678
INE90_RS15075	COG4771	TonB-dependent receptor
INE90_RS15110	COG0110	maltose O-acetyltransferase activity
INE90_RS15125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INE90_RS15140	COG0738	Major facilitator superfamily
INE90_RS15150	COG2059	Chromate
INE90_RS15160	COG3969	phosphoadenosine phosphosulfate
INE90_RS15165	COG1475	DNA binding
INE90_RS15170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE90_RS15185	COG1074	ATP-dependent DNA helicase activity
INE90_RS15195	COG0556	nucleotide-excision repair
INE90_RS15200	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
INE90_RS15230	COG1388	LysM domain
INE90_RS15230	COG3942	CHAP domain
INE90_RS15235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INE90_RS15240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INE90_RS15245	COG3104	oligopeptide transport
INE90_RS15260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INE90_RS15270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INE90_RS15275	COG1695	Transcriptional regulator
INE90_RS15295	COG1086	Polysaccharide biosynthesis protein
INE90_RS15300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE90_RS15305	COG1083	cytidylyl-transferase
INE90_RS15325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INE90_RS15330	COG2089	acid synthase
INE90_RS15405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE90_RS15435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE90_RS15440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE90_RS15455	COG3250	beta-galactosidase activity
INE90_RS15460	COG2755	lipolytic protein G-D-S-L family
INE90_RS15460	COG0657	acetylesterase activity
INE90_RS15485	COG3059	membrane
INE90_RS15490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INE90_RS15505	COG1120	ATPase activity
INE90_RS15510	COG0534	Mate efflux family protein
INE90_RS15515	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
INE90_RS15525	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
INE90_RS15555	COG4771	TonB-dependent receptor
INE90_RS15575	COG1429	ligase activity, forming nitrogen-metal bonds
INE90_RS15595	COG4771	TonB-dependent receptor
INE90_RS15610	COG4772	TonB-dependent receptor
INE90_RS15625	COG0439	Biotin carboxylase
INE90_RS15635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INE90_RS15645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
INE90_RS15655	COG1797	cobyrinic acid a,c-diamide synthase activity
INE90_RS15695	COG2096	Adenosyltransferase
INE90_RS15700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
INE90_RS15720	COG1492	cobalamin metabolic process
INE90_RS15730	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
INE90_RS15735	COG2205	protein histidine kinase activity
INE90_RS15735	COG2202	Pas domain
INE90_RS15740	COG2202	Pas domain
INE90_RS15740	COG2205	protein histidine kinase activity
INE90_RS15755	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
INE90_RS15770	COG4974	Belongs to the 'phage' integrase family
INE90_RS15870	COG2186	Transcriptional regulator
INE90_RS15875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INE90_RS15880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE90_RS15885	COG4771	TonB-dependent receptor
INE90_RS15890	COG0702	epimerase
INE90_RS15910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
INE90_RS15915	COG2731	YhcH YjgK YiaL family protein
INE90_RS15920	COG0442	prolyl-tRNA aminoacylation
INE90_RS15975	COG2244	polysaccharide biosynthetic process
INE90_RS16055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
INE90_RS16075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE90_RS16080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INE90_RS16090	COG0823	Involved in the tonB-independent uptake of proteins
INE90_RS16090	COG1506	peptidase
INE90_RS16095	COG0534	Mate efflux family protein
INE90_RS16105	COG0504	CTP synthase activity
INE90_RS16125	COG4656	Part of a membrane complex involved in electron transport
INE90_RS16130	COG4658	electron transport chain
INE90_RS16135	COG4659	FMN binding
INE90_RS16140	COG4660	Part of a membrane complex involved in electron transport
INE90_RS16145	COG4657	Part of a membrane complex involved in electron transport
INE90_RS16150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INE90_RS16170	COG0356	it plays a direct role in the translocation of protons across the membrane
INE90_RS16175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE90_RS16180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INE90_RS16185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INE90_RS16190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INE90_RS16195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INE90_RS16200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INE90_RS16235	COG2759	Belongs to the formate--tetrahydrofolate ligase family
INE90_RS16240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INE90_RS16255	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
INE90_RS16260	COG0540	Belongs to the ATCase OTCase family
INE90_RS16265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INE90_RS16275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
INE90_RS16290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INE90_RS16295	COG2205	protein histidine kinase activity
INE90_RS16310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
INE90_RS16335	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INE90_RS16380	COG0351	phosphomethylpyrimidine kinase
INE90_RS16385	COG0352	thiamine-phosphate diphosphorylase activity
INE90_RS16400	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
INE90_RS16405	COG2022	thiamine diphosphate biosynthetic process
INE90_RS16410	COG0352	thiamine-phosphate diphosphorylase activity
INE90_RS16420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INE90_RS16435	COG2115	Belongs to the xylose isomerase family
INE90_RS16440	COG0477	Major facilitator Superfamily
INE90_RS16440	COG2814	Major facilitator Superfamily
INE90_RS16445	COG3153	acetyltransferase
INE90_RS16445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INE90_RS16455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INE90_RS16465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INE90_RS16480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INE90_RS16500	COG1252	NADH dehydrogenase
INE90_RS16510	COG2194	sulfuric ester hydrolase activity
INE90_RS16535	COG2249	NAD(P)H dehydrogenase (quinone) activity
INE90_RS16555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INE90_RS16570	COG1904	glucuronate isomerase
INE90_RS16575	COG1609	Transcriptional regulator
INE90_RS16580	COG0246	Mannitol dehydrogenase
INE90_RS16615	COG0513	Belongs to the DEAD box helicase family
INE90_RS16620	COG0560	Phosphoserine phosphatase
INE90_RS16620	COG3830	Belongs to the UPF0237 family
INE90_RS16635	COG0343	queuine tRNA-ribosyltransferase activity
INE90_RS16640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
INE90_RS16645	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
INE90_RS16915	COG1484	DNA-dependent DNA replication
INE90_RS16935	COG1061	Type III restriction enzyme res subunit
INE90_RS17215	COG0358	DNA primase activity
INE90_RS17335	COG1136	(ABC) transporter
INE90_RS17365	COG0501	Belongs to the peptidase M48B family
INE90_RS17370	COG0156	8-amino-7-oxononanoate synthase activity
INE90_RS17375	COG1597	lipid kinase activity
INE90_RS17380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INE90_RS17395	COG2957	Belongs to the agmatine deiminase family
INE90_RS17405	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
INE90_RS17410	COG0390	transport system, permease component
INE90_RS17425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INE90_RS17445	COG1538	Outer membrane efflux protein
INE90_RS17470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INE90_RS17485	COG0543	2 iron, 2 sulfur cluster binding
INE90_RS17490	COG0167	dihydroorotate dehydrogenase activity
INE90_RS17495	COG0336	Belongs to the RNA methyltransferase TrmD family
INE90_RS17500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INE90_RS17505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INE90_RS17530	COG0542	response to heat
INE90_RS17535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INE90_RS17575	COG2304	oxidoreductase activity
INE90_RS17590	COG0714	Associated with various cellular activities
INE90_RS17605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE90_RS17610	COG0552	protein localization to endoplasmic reticulum
INE90_RS17620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INE90_RS17625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INE90_RS17630	COG1546	Belongs to the CinA family
INE90_RS17630	COG1058	Belongs to the CinA family
INE90_RS17635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INE90_RS17645	COG0305	Participates in initiation and elongation during chromosome replication
INE90_RS17650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
INE90_RS17660	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
INE90_RS17670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INE90_RS17675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
INE90_RS17685	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
INE90_RS17690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INE90_RS17695	COG0534	Mate efflux family protein
INE90_RS17705	COG1136	(ABC) transporter
INE90_RS17705	COG0577	efflux transmembrane transporter activity
INE90_RS17710	COG1136	(ABC) transporter
INE90_RS17735	COG2205	protein histidine kinase activity
INE90_RS17740	COG3263	regulation of cellular component size
INE90_RS17745	COG0318	PFAM AMP-dependent synthetase and ligase
INE90_RS17750	COG1082	Xylose isomerase domain protein TIM barrel
INE90_RS17770	COG0702	epimerase
INE90_RS17775	COG4771	TonB-dependent receptor
INE90_RS17790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INE90_RS17800	COG2755	lipolytic protein G-D-S-L family
INE90_RS17800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE90_RS17810	COG0842	Transport permease protein
INE90_RS17815	COG1131	(ABC) transporter
INE90_RS17830	COG1917	Cupin 2, conserved barrel domain protein
INE90_RS17830	COG2207	Transcriptional regulator
INE90_RS17835	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INE90_RS17840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INE90_RS17845	COG0505	Belongs to the CarA family
INE90_RS17855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INE90_RS17860	COG0070	glutamate synthase
INE90_RS17860	COG0067	glutamate synthase
INE90_RS17860	COG0069	glutamate synthase activity
INE90_RS17870	COG0367	asparagine synthase
INE90_RS17895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INE90_RS17900	COG0110	maltose O-acetyltransferase activity
INE90_RS17905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INE90_RS17910	COG0438	transferase activity, transferring glycosyl groups
INE90_RS17950	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
INE90_RS17970	COG0562	UDP-galactopyranose mutase
INE90_RS17995	COG2433	Pfam Transposase IS66
INE90_RS18040	COG0436	Aminotransferase
INE90_RS18050	COG0347	Belongs to the P(II) protein family
INE90_RS18055	COG0004	ammonium transporteR
INE90_RS18075	COG0133	tryptophan synthase activity
INE90_RS18080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INE90_RS18085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INE90_RS18085	COG0512	Glutamine amidotransferase of anthranilate synthase
INE90_RS18090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INE90_RS18095	COG0134	indole-3-glycerol-phosphate synthase activity
INE90_RS18100	COG0135	phosphoribosylanthranilate isomerase activity
INE90_RS18105	COG0159	tryptophan synthase activity
INE90_RS18110	COG0252	asparaginase activity
INE90_RS18120	COG0745	RESPONSE REGULATOR receiver
INE90_RS18165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INE90_RS18220	COG0438	transferase activity, transferring glycosyl groups
INE90_RS18225	COG1216	Glycosyl transferase, family 2
INE90_RS18230	COG1216	Glycosyl transferase, family 2
INE90_RS18260	COG1609	Transcriptional regulator
INE90_RS18265	COG2721	sulfolactate sulfo-lyase activity
INE90_RS18275	COG0228	four-way junction DNA binding
INE90_RS18280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INE90_RS18310	COG0588	phosphoglycerate mutase activity
INE90_RS18320	COG0716	FMN binding
INE90_RS18325	COG0058	SHG alpha-glucan phosphorylase activity
INE90_RS18355	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
INE90_RS18690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INE90_RS18695	COG1696	Membrane protein involved in D-alanine export
INE90_RS18720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE90_RS18730	COG1309	transcriptional regulator
INE90_RS18735	COG2986	histidine ammonia-lyase
INE90_RS18745	COG1228	amidohydrolase
INE90_RS18755	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
INE90_RS18770	COG2431	L-lysine efflux transmembrane transporter activity
INE90_RS18785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE90_RS18800	COG0203	ribosomal protein L17
INE90_RS18805	COG0202	RNA polymerase activity
INE90_RS18810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INE90_RS18815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
INE90_RS18820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INE90_RS18825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INE90_RS18830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INE90_RS18845	COG0200	Binds to the 23S rRNA
INE90_RS18850	COG1841	ribosomal large subunit assembly
INE90_RS18855	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INE90_RS18860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INE90_RS18865	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INE90_RS18870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INE90_RS18875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INE90_RS18880	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INE90_RS18885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INE90_RS18890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INE90_RS18895	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INE90_RS18900	COG0255	Belongs to the universal ribosomal protein uL29 family
INE90_RS18905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INE90_RS18910	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INE90_RS18915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INE90_RS18920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INE90_RS18925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INE90_RS18930	COG0089	rRNA binding
INE90_RS18935	COG0088	Forms part of the polypeptide exit tunnel
INE90_RS18940	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INE90_RS18945	COG0051	transcription antitermination factor activity, RNA binding
INE90_RS18950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INE90_RS18955	COG0049	tRNA binding
INE90_RS18960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INE90_RS18970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INE90_RS18975	COG0085	RNA polymerase activity
INE90_RS18980	COG0222	ribosome binding
INE90_RS18985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INE90_RS18990	COG0081	regulation of translation
INE90_RS18995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INE90_RS19040	COG4974	Belongs to the 'phage' integrase family
INE90_RS19045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
INE90_RS19050	COG0006	proline dipeptidase activity
INE90_RS19055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
INE90_RS19065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INE90_RS19130	COG2433	Pfam Transposase IS66
INE90_RS19205	COG3550	peptidyl-serine autophosphorylation
INE90_RS19225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INE90_RS19230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INE90_RS19280	COG3189	MarR family transcriptional regulator
INE90_RS19285	COG0514	ATP-dependent DNA helicase (RecQ)
INE90_RS19295	COG2096	Adenosyltransferase
INE90_RS19315	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS19320	COG3250	beta-galactosidase activity
INE90_RS19325	COG1501	Belongs to the glycosyl hydrolase 31 family
INE90_RS19330	COG2205	protein histidine kinase activity
INE90_RS19330	COG0745	RESPONSE REGULATOR receiver
INE90_RS19330	COG3292	Two component regulator propeller
INE90_RS19335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE90_RS19340	COG3507	Belongs to the glycosyl hydrolase 43 family
INE90_RS19370	COG4771	TonB-dependent receptor
INE90_RS19380	COG0784	Response regulator, receiver
INE90_RS19380	COG2205	protein histidine kinase activity
INE90_RS19425	COG0358	DNA primase activity
INE90_RS19450	COG0582	viral genome integration into host DNA
INE90_RS19485	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
INE90_RS19505	COG0732	type I restriction modification DNA specificity domain
INE90_RS19510	COG4974	Belongs to the 'phage' integrase family
INE90_RS19515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
INE90_RS19530	COG4974	Belongs to the 'phage' integrase family
INE90_RS19535	COG4804	nuclease activity
INE90_RS19545	COG1051	belongs to the nudix hydrolase family
INE90_RS19550	COG0546	phosphoglycolate phosphatase activity
INE90_RS19585	COG0358	DNA primase activity
INE90_RS19660	COG3385	transposase activity
INE90_RS19685	COG0537	adenosine 5'-monophosphoramidase activity
INE90_RS19690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INE90_RS19700	COG1185	polyribonucleotide nucleotidyltransferase activity
INE90_RS19715	COG4206	TonB-dependent receptor
INE90_RS19715	COG1629	transport
INE90_RS19725	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
INE90_RS19735	COG0393	Putative heavy-metal-binding
INE90_RS19740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INE90_RS19745	COG0719	Fe-S assembly protein
INE90_RS19750	COG0396	ATPase activity
INE90_RS19755	COG0719	Fe-S assembly protein
INE90_RS19765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INE90_RS19770	COG0195	Participates in both transcription termination and antitermination
INE90_RS19775	COG0779	Required for maturation of 30S ribosomal subunits
INE90_RS19780	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS19785	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS19790	COG2382	esterase
INE90_RS19795	COG2382	esterase
INE90_RS19800	COG2382	esterase
INE90_RS19800	COG3507	Belongs to the glycosyl hydrolase 43 family
INE90_RS19800	COG3693	PFAM glycoside hydrolase, family 10
INE90_RS19805	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS19810	COG0702	epimerase
INE90_RS19815	COG4206	TonB-dependent receptor
INE90_RS19815	COG1629	transport
INE90_RS19820	COG2272	Belongs to the type-B carboxylesterase lipase family
INE90_RS19825	COG0745	RESPONSE REGULATOR receiver
INE90_RS19825	COG2205	protein histidine kinase activity
INE90_RS19825	COG3292	Two component regulator propeller
INE90_RS19850	COG1595	DNA-templated transcription, initiation
INE90_RS19855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INE90_RS19860	COG1166	arginine decarboxylase activity
INE90_RS19865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INE90_RS19875	COG3341	Caulimovirus viroplasmin
INE90_RS19875	COG0328	RNA-DNA hybrid ribonuclease activity
INE90_RS19890	COG0673	inositol 2-dehydrogenase activity
INE90_RS19895	COG0673	inositol 2-dehydrogenase activity
INE90_RS19900	COG1132	(ABC) transporter
INE90_RS19935	COG1442	glycosyl transferase family 8
INE90_RS19935	COG1216	Glycosyl transferase, family 2
INE90_RS19960	COG3754	Rhamnan synthesis protein F
INE90_RS19965	COG1216	Glycosyl transferase, family 2
INE90_RS19965	COG1442	glycosyl transferase family 8
INE90_RS19975	COG1368	sulfuric ester hydrolase activity
INE90_RS19985	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
INE90_RS19990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
INE90_RS19995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
INE90_RS19995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INE90_RS20010	COG3475	LICD family
INE90_RS20015	COG4750	Nucleotidyl transferase
INE90_RS20020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INE90_RS20025	COG0438	transferase activity, transferring glycosyl groups
INE90_RS20035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INE90_RS20040	COG3083	sulfuric ester hydrolase activity
INE90_RS20045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INE90_RS20050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INE90_RS20055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INE90_RS20060	COG0571	ribonuclease III activity
INE90_RS20065	COG0205	6-phosphofructokinase activity
INE90_RS20080	COG0482	sulfurtransferase activity
INE90_RS20095	COG3119	arylsulfatase activity
INE90_RS20100	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INE90_RS20120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INE90_RS20135	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INE90_RS20150	COG0745	RESPONSE REGULATOR receiver
INE90_RS20150	COG3292	Two component regulator propeller
INE90_RS20150	COG2205	protein histidine kinase activity
INE90_RS20150	COG3292	Two component regulator propeller
INE90_RS20150	COG2205	protein histidine kinase activity
INE90_RS20150	COG0745	RESPONSE REGULATOR receiver
INE90_RS20155	COG3119	arylsulfatase activity
INE90_RS20175	COG5492	domain, Protein
INE90_RS20185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE90_RS20210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INE90_RS20220	COG0681	Belongs to the peptidase S26 family
INE90_RS20235	COG1028	Short-chain dehydrogenase reductase Sdr
INE90_RS20240	COG1312	Catalyzes the dehydration of D-mannonate
INE90_RS20250	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS20255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE90_RS20270	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INE90_RS20275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
INE90_RS20280	COG0612	Peptidase, M16
INE90_RS20285	COG0582	viral genome integration into host DNA
INE90_RS20330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INE90_RS20345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE90_RS20345	COG0784	Response regulator, receiver
INE90_RS20345	COG2198	Histidine kinase
INE90_RS20345	COG2205	protein histidine kinase activity
INE90_RS20360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE90_RS20385	COG0513	Belongs to the DEAD box helicase family
INE90_RS20390	COG0783	Belongs to the Dps family
INE90_RS20395	COG0583	DNA-binding transcription factor activity
INE90_RS20405	COG3634	alkyl hydroperoxide reductase activity
INE90_RS20410	COG3591	Belongs to the peptidase S1B family
INE90_RS20425	COG2255	four-way junction helicase activity
INE90_RS20450	COG2234	aminopeptidase activity
INE90_RS20455	COG2715	membrane protein required for spore maturation
INE90_RS20460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INE90_RS20485	COG2017	converts alpha-aldose to the beta-anomer
INE90_RS20495	COG3408	Glycogen debranching enzyme
INE90_RS20525	COG4771	TonB-dependent receptor
INE90_RS20530	COG0745	RESPONSE REGULATOR receiver
INE90_RS20530	COG3292	Two component regulator propeller
INE90_RS20530	COG2205	protein histidine kinase activity
INE90_RS20530	COG0745	RESPONSE REGULATOR receiver
INE90_RS20530	COG3292	Two component regulator propeller
INE90_RS20530	COG2205	protein histidine kinase activity
INE90_RS20545	COG1629	transport
INE90_RS20545	COG4206	TonB-dependent receptor
INE90_RS20555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INE90_RS20560	COG0322	excinuclease ABC activity
INE90_RS20565	COG1490	D-aminoacyl-tRNA deacylase activity
INE90_RS20570	COG1694	Mazg nucleotide pyrophosphohydrolase
INE90_RS20580	COG0142	geranyltranstransferase activity
INE90_RS20585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE90_RS20585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INE90_RS20605	COG0012	GTP binding
INE90_RS20620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INE90_RS20625	COG1501	Belongs to the glycosyl hydrolase 31 family
INE90_RS20630	COG1472	Belongs to the glycosyl hydrolase 3 family
INE90_RS20635	COG3408	Glycogen debranching enzyme
INE90_RS20655	COG0702	epimerase
INE90_RS20660	COG1629	transport
INE90_RS20660	COG4206	TonB-dependent receptor
INE90_RS20685	COG4948	Mandelate Racemase Muconate Lactonizing
INE90_RS20690	COG3292	Two component regulator propeller
INE90_RS20690	COG2205	protein histidine kinase activity
INE90_RS20690	COG0745	RESPONSE REGULATOR receiver
INE90_RS20695	COG3250	beta-galactosidase activity
INE90_RS20700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INE90_RS20740	COG0745	RESPONSE REGULATOR receiver
INE90_RS20760	COG0383	alpha-mannosidase activity
INE90_RS20790	COG4948	Mandelate Racemase Muconate Lactonizing
INE90_RS20820	COG4771	TonB-dependent receptor
INE90_RS20835	COG0738	Major facilitator superfamily
INE90_RS20850	COG1609	Transcriptional regulator
INE90_RS20880	COG1629	transport
INE90_RS20880	COG4206	TonB-dependent receptor
INE90_RS20900	COG4771	TonB-dependent receptor
INE90_RS20915	COG2433	Pfam Transposase IS66
INE90_RS20930	COG0697	spore germination
INE90_RS20935	COG0495	leucyl-tRNA aminoacylation
INE90_RS20940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE90_RS20945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INE90_RS20950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
INE90_RS20960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INE90_RS20980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INE90_RS20980	COG0731	radical SAM domain protein
INE90_RS20995	COG0659	secondary active sulfate transmembrane transporter activity
INE90_RS21000	COG1592	Rubrerythrin
INE90_RS21015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
INE90_RS21105	COG0427	acetyl-CoA hydrolase
INE90_RS21115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INE90_RS21125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INE90_RS21130	COG2177	Part of the ABC transporter FtsEX involved in
INE90_RS21140	COG1968	undecaprenyl-diphosphatase activity
INE90_RS21145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INE90_RS21150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INE90_RS21155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INE90_RS21155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INE90_RS21160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INE90_RS21165	COG2205	protein histidine kinase activity
INE90_RS21165	COG0784	Response regulator, receiver
INE90_RS21195	COG3023	N-Acetylmuramoyl-L-alanine amidase
INE90_RS21255	COG1611	Belongs to the LOG family
INE90_RS21270	COG0594	ribonuclease P activity
INE90_RS21275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INE90_RS21280	COG0084	hydrolase, TatD family'
INE90_RS21285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INE90_RS21300	COG1028	Short-chain dehydrogenase reductase Sdr
INE90_RS21315	COG4585	Histidine kinase
INE90_RS21375	COG3291	Pkd domain containing protein
INE90_RS21380	COG0745	RESPONSE REGULATOR receiver
INE90_RS21380	COG2205	protein histidine kinase activity
INE90_RS21380	COG3292	Two component regulator propeller
INE90_RS21385	COG1501	Belongs to the glycosyl hydrolase 31 family
INE90_RS21395	COG1629	transport
INE90_RS21395	COG4206	TonB-dependent receptor
INE90_RS21405	COG2942	2-epimerase
INE90_RS21435	COG1238	metal cluster binding
INE90_RS21445	COG0151	Belongs to the GarS family
INE90_RS21450	COG1506	peptidase
INE90_RS21450	COG0823	Involved in the tonB-independent uptake of proteins
INE90_RS21455	COG0116	Belongs to the methyltransferase superfamily
INE90_RS21455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INE90_RS21460	COG1045	serine acetyltransferase
INE90_RS21475	COG0557	exoribonuclease II activity
INE90_RS21500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INE90_RS21505	COG0826	peptidase U32
INE90_RS21540	COG3328	transposase activity
INE90_RS21550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INE90_RS21555	COG1053	succinate dehydrogenase
INE90_RS21570	COG0671	phosphoesterase, PA-phosphatase related
INE90_RS21575	COG0793	Belongs to the peptidase S41A family
INE90_RS21575	COG3409	Peptidoglycan-binding domain 1 protein
INE90_RS21580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INE90_RS21625	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
INE90_RS21625	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
INE90_RS21635	COG1940	carbohydrate kinase activity
INE90_RS21650	COG2814	Major facilitator Superfamily
INE90_RS21665	COG4206	TonB-dependent receptor
INE90_RS21665	COG1629	transport
INE90_RS21675	COG4771	TonB-dependent receptor
INE90_RS21680	COG0702	epimerase
INE90_RS21700	COG2755	lipolytic protein G-D-S-L family
INE90_RS21700	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INE90_RS21720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INE90_RS21730	COG3250	beta-galactosidase activity
INE90_RS21735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INE90_RS21810	COG3344	reverse transcriptase
INE90_RS21930	COG2095	MarC family integral membrane protein
INE90_RS21940	COG1830	Aldolase
INE90_RS21945	COG0588	phosphoglycerate mutase activity
INE90_RS21960	COG0205	6-phosphofructokinase activity
INE90_RS21965	COG4651	solute:proton antiporter activity
INE90_RS21965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INE90_RS21970	COG0058	SHG alpha-glucan phosphorylase activity
INE90_RS21975	COG0010	Belongs to the arginase family
INE90_RS21980	COG1803	Methylglyoxal synthase
INE90_RS21985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE90_RS21985	COG2205	protein histidine kinase activity
INE90_RS21985	COG2198	Histidine kinase
INE90_RS21985	COG0784	Response regulator, receiver
INE90_RS22040	COG0739	heme binding
INE90_RS22040	COG0741	lytic transglycosylase activity
INE90_RS22040	COG1196	nuclear chromosome segregation
INE90_RS22110	COG4974	Belongs to the 'phage' integrase family
INE90_RS22145	COG1196	nuclear chromosome segregation
INE90_RS22155	COG3328	transposase activity
INE90_RS22180	COG1522	sequence-specific DNA binding
INE90_RS22185	COG0545	Peptidyl-prolyl cis-trans isomerase
INE90_RS22190	COG0545	Peptidyl-prolyl cis-trans isomerase
INE90_RS22195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INE90_RS22205	COG0438	transferase activity, transferring glycosyl groups
INE90_RS22215	COG3475	LICD family
INE90_RS22235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE90_RS22235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INE90_RS22255	COG3279	Response regulator of the LytR AlgR family
INE90_RS22265	COG3594	Acyltransferase
INE90_RS22340	COG0358	DNA primase activity
INE90_RS22455	COG2204	response regulator
INE90_RS22460	COG0784	Response regulator, receiver
INE90_RS22460	COG2205	protein histidine kinase activity
INE90_RS22460	COG2198	Histidine kinase
INE90_RS22460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INE90_RS22510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INE90_RS22510	COG0551	DNA topoisomerase type I activity
INE90_RS22545	COG4974	Belongs to the 'phage' integrase family
INE90_RS22675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INE90_RS22690	COG0784	Response regulator, receiver
INE90_RS22690	COG2205	protein histidine kinase activity
INE90_RS22700	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INE90_RS22715	COG1192	Involved in chromosome partitioning
INE90_RS22825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INE90_RS22830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INE90_RS22860	COG0438	transferase activity, transferring glycosyl groups
INE90_RS22870	COG1216	Glycosyl transferase, family 2
INE90_RS22870	COG1442	glycosyl transferase family 8
INE90_RS22885	COG0662	Cupin 2, conserved barrel domain protein
INE90_RS22885	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
INE90_RS23015	COG0629	single-stranded DNA binding
INE90_RS23100	COG3385	transposase activity
INE90_RS23105	COG4474	Belongs to the UPF0398 family
INE90_RS23165	COG0776	regulation of translation
INE90_RS23175	COG2337	Toxic component of a toxin-antitoxin (TA) module
INE90_RS23210	COG2003	Belongs to the UPF0758 family
INE90_RS23275	COG3385	transposase activity
INE90_RS23290	COG4206	TonB-dependent receptor
INE90_RS23290	COG1629	transport
INE90_RS23295	COG4771	TonB-dependent receptor
INE90_RS23410	COG3507	Belongs to the glycosyl hydrolase 43 family
INE90_RS23445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INE90_RS23485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
INE90_RS23510	COG2205	protein histidine kinase activity
INE90_RS23570	COG1115	amino acid carrier protein
INE90_RS23575	COG0662	Cupin 2, conserved barrel domain protein
INE90_RS23575	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family