locus-tag	class	description
GFH35_RS00070	COG0358	DNA primase activity
GFH35_RS00075	COG4974	Belongs to the 'phage' integrase family
GFH35_RS00080	COG0582	viral genome integration into host DNA
GFH35_RS00085	COG0582	viral genome integration into host DNA
GFH35_RS00090	COG4974	Belongs to the 'phage' integrase family
GFH35_RS00165	COG3344	reverse transcriptase
GFH35_RS00180	COG3344	reverse transcriptase
GFH35_RS00185	COG3344	reverse transcriptase
GFH35_RS00255	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GFH35_RS00385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFH35_RS00420	COG1475	DNA binding
GFH35_RS00430	COG1192	Involved in chromosome partitioning
GFH35_RS00465	COG0739	heme binding
GFH35_RS00465	COG0741	lytic transglycosylase activity
GFH35_RS00465	COG1196	nuclear chromosome segregation
GFH35_RS00525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFH35_RS00640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH35_RS00645	COG1120	ATPase activity
GFH35_RS00740	COG2204	response regulator
GFH35_RS00745	COG0784	Response regulator, receiver
GFH35_RS00745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH35_RS00745	COG2198	Histidine kinase
GFH35_RS00745	COG2205	protein histidine kinase activity
GFH35_RS00800	COG3344	reverse transcriptase
GFH35_RS00815	COG0551	DNA topoisomerase type I activity
GFH35_RS00815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFH35_RS00860	COG1678	Uncharacterized ACR, COG1678
GFH35_RS00875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFH35_RS00885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GFH35_RS00905	COG2755	lipolytic protein G-D-S-L family
GFH35_RS00905	COG0657	acetylesterase activity
GFH35_RS00915	COG0321	lipoyl(octanoyl) transferase activity
GFH35_RS00925	COG2217	Heavy metal translocating P-type atpase
GFH35_RS00945	COG1408	metallophosphoesterase
GFH35_RS00960	COG0357	Ribosomal RNA small subunit methyltransferase G
GFH35_RS00965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH35_RS00970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH35_RS00970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH35_RS00975	COG0778	Nitroreductase
GFH35_RS01010	COG1739	Uncharacterized protein family UPF0029
GFH35_RS01025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GFH35_RS01030	COG0513	Belongs to the DEAD box helicase family
GFH35_RS01040	COG2871	sodium ion transport
GFH35_RS01055	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GFH35_RS01060	COG1805	sodium ion transport
GFH35_RS01095	COG1215	transferase activity, transferring glycosyl groups
GFH35_RS01110	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS01155	COG1442	glycosyl transferase family 8
GFH35_RS01155	COG1216	Glycosyl transferase, family 2
GFH35_RS01160	COG2244	polysaccharide biosynthetic process
GFH35_RS01170	COG0438	transferase activity, transferring glycosyl groups
GFH35_RS01185	COG1368	sulfuric ester hydrolase activity
GFH35_RS01195	COG0784	Response regulator, receiver
GFH35_RS01195	COG2205	protein histidine kinase activity
GFH35_RS01205	COG4206	TonB-dependent receptor
GFH35_RS01205	COG1629	transport
GFH35_RS01210	COG0488	(ABC) transporter
GFH35_RS01220	COG0784	Response regulator, receiver
GFH35_RS01220	COG2205	protein histidine kinase activity
GFH35_RS01225	COG0657	acetylesterase activity
GFH35_RS01225	COG2755	lipolytic protein G-D-S-L family
GFH35_RS01230	COG0534	Mate efflux family protein
GFH35_RS01235	COG2885	chlorophyll binding
GFH35_RS01240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH35_RS01250	COG1704	LemA family
GFH35_RS01255	COG0501	Belongs to the peptidase M48B family
GFH35_RS01280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFH35_RS01285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFH35_RS01295	COG1271	oxidase subunit
GFH35_RS01310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH35_RS01315	COG1136	(ABC) transporter
GFH35_RS01320	COG0577	efflux transmembrane transporter activity
GFH35_RS01320	COG1136	(ABC) transporter
GFH35_RS01330	COG3279	Response regulator of the LytR AlgR family
GFH35_RS01425	COG1595	DNA-templated transcription, initiation
GFH35_RS01495	COG3728	DNA packaging
GFH35_RS01540	COG0582	viral genome integration into host DNA
GFH35_RS01615	COG1475	DNA binding
GFH35_RS01640	COG1061	Type III restriction enzyme res subunit
GFH35_RS01660	COG0629	single-stranded DNA binding
GFH35_RS01770	COG2837	iron assimilation
GFH35_RS01775	COG0363	glucosamine-6-phosphate deaminase activity
GFH35_RS01780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GFH35_RS01785	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GFH35_RS01790	COG1301	dicarboxylic acid transport
GFH35_RS01795	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GFH35_RS01800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH35_RS01805	COG1022	Amp-dependent synthetase and ligase
GFH35_RS01820	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GFH35_RS01825	COG2985	domain, Protein
GFH35_RS01825	COG0490	domain, Protein
GFH35_RS01840	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GFH35_RS01880	COG0737	Belongs to the 5'-nucleotidase family
GFH35_RS01885	COG2205	protein histidine kinase activity
GFH35_RS01885	COG2202	Pas domain
GFH35_RS01890	COG2183	response to ionizing radiation
GFH35_RS01910	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS01940	COG0488	(ABC) transporter
GFH35_RS01945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFH35_RS01950	COG0484	heat shock protein binding
GFH35_RS01955	COG4335	DNA alkylation repair
GFH35_RS01960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH35_RS01965	COG4771	TonB-dependent receptor
GFH35_RS01970	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH35_RS01975	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH35_RS02000	COG1629	transport
GFH35_RS02045	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH35_RS02070	COG0561	phosphatase activity
GFH35_RS02075	COG1629	transport
GFH35_RS02095	COG2814	Major facilitator Superfamily
GFH35_RS02110	COG1940	carbohydrate kinase activity
GFH35_RS02125	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GFH35_RS02135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFH35_RS02145	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFH35_RS02145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GFH35_RS02145	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFH35_RS02145	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFH35_RS02150	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GFH35_RS02155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFH35_RS02165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFH35_RS02170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFH35_RS02175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFH35_RS02180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFH35_RS02190	COG0242	peptide deformylase activity
GFH35_RS02195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFH35_RS02215	COG2895	sulfate adenylyltransferase (ATP) activity
GFH35_RS02220	COG0175	sulfate reduction
GFH35_RS02225	COG0529	Catalyzes the synthesis of activated sulfate
GFH35_RS02230	COG0471	metal ion transport
GFH35_RS02230	COG3273	potassium ion transport
GFH35_RS02235	COG1218	3'(2'),5'-bisphosphate nucleotidase
GFH35_RS02245	COG4221	oxidoreductase activity
GFH35_RS02290	COG0110	maltose O-acetyltransferase activity
GFH35_RS02295	COG0297	glycogen (starch) synthase activity
GFH35_RS02300	COG0110	maltose O-acetyltransferase activity
GFH35_RS02305	COG0438	transferase activity, transferring glycosyl groups
GFH35_RS02320	COG0438	transferase activity, transferring glycosyl groups
GFH35_RS02325	COG0562	UDP-galactopyranose mutase
GFH35_RS02330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GFH35_RS02335	COG1882	Formate acetyltransferase
GFH35_RS02345	COG1216	Glycosyl transferase, family 2
GFH35_RS02360	COG1216	Glycosyl transferase, family 2
GFH35_RS02440	COG4974	Belongs to the 'phage' integrase family
GFH35_RS02445	COG1482	cell wall glycoprotein biosynthetic process
GFH35_RS02460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GFH35_RS02480	COG2816	NAD+ diphosphatase activity
GFH35_RS02490	COG2160	L-arabinose isomerase activity
GFH35_RS02495	COG1070	Carbohydrate kinase
GFH35_RS02515	COG0698	ribose 5-phosphate isomerase
GFH35_RS02520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GFH35_RS02535	COG5012	cobalamin binding
GFH35_RS02540	COG1501	Belongs to the glycosyl hydrolase 31 family
GFH35_RS02615	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GFH35_RS02620	COG0673	inositol 2-dehydrogenase activity
GFH35_RS02625	COG0590	tRNA wobble adenosine to inosine editing
GFH35_RS02645	COG2264	protein methyltransferase activity
GFH35_RS02655	COG0022	dehydrogenase e1 component
GFH35_RS02660	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH35_RS02700	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFH35_RS02720	COG4974	Belongs to the 'phage' integrase family
GFH35_RS02740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH35_RS02745	COG0363	glucosamine-6-phosphate deaminase activity
GFH35_RS02765	COG1032	radical SAM domain protein
GFH35_RS02770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFH35_RS02775	COG0463	Glycosyl transferase, family 2
GFH35_RS02780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFH35_RS02785	COG1410	methionine synthase
GFH35_RS02785	COG0646	methionine synthase
GFH35_RS02805	COG0420	3'-5' exonuclease activity
GFH35_RS02830	COG0641	radical SAM
GFH35_RS02835	COG3591	Belongs to the peptidase S1B family
GFH35_RS02840	COG3591	Belongs to the peptidase S1B family
GFH35_RS02855	COG3118	belongs to the thioredoxin family
GFH35_RS02870	COG1773	rubredoxin
GFH35_RS02870	COG1592	Rubrerythrin
GFH35_RS02920	COG4206	TonB-dependent receptor
GFH35_RS02920	COG1629	transport
GFH35_RS02925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH35_RS02925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFH35_RS02935	COG0131	Imidazoleglycerol-phosphate dehydratase
GFH35_RS02940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFH35_RS02945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFH35_RS02950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFH35_RS02970	COG2271	Major facilitator Superfamily
GFH35_RS02995	COG0702	epimerase
GFH35_RS03000	COG4771	TonB-dependent receptor
GFH35_RS03015	COG4232	protein-disulfide reductase activity
GFH35_RS03025	COG0572	uridine kinase
GFH35_RS03030	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GFH35_RS03040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH35_RS03045	COG0778	Nitroreductase
GFH35_RS03050	COG1410	methionine synthase
GFH35_RS03050	COG0646	methionine synthase
GFH35_RS03055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GFH35_RS03120	COG0545	Peptidyl-prolyl cis-trans isomerase
GFH35_RS03125	COG2373	Large extracellular alpha-helical protein
GFH35_RS03130	COG4953	penicillin-binding protein 1C
GFH35_RS03135	COG2814	Major facilitator Superfamily
GFH35_RS03145	COG1757	Na H antiporter
GFH35_RS03155	COG2197	response regulator
GFH35_RS03170	COG0482	sulfurtransferase activity
GFH35_RS03200	COG0501	Belongs to the peptidase M48B family
GFH35_RS03205	COG1253	flavin adenine dinucleotide binding
GFH35_RS03215	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH35_RS03240	COG3344	reverse transcriptase
GFH35_RS03250	COG0702	epimerase
GFH35_RS03255	COG4206	TonB-dependent receptor
GFH35_RS03255	COG1629	transport
GFH35_RS03270	COG3250	beta-galactosidase activity
GFH35_RS03280	COG5492	domain, Protein
GFH35_RS03290	COG1629	transport
GFH35_RS03340	COG0656	L-ascorbic acid biosynthetic process
GFH35_RS03345	COG4948	Mandelate Racemase Muconate Lactonizing
GFH35_RS03350	COG0662	Cupin 2, conserved barrel domain protein
GFH35_RS03350	COG2207	Transcriptional regulator
GFH35_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
GFH35_RS03390	COG0561	phosphatase activity
GFH35_RS03395	COG1629	transport
GFH35_RS03400	COG1595	DNA-templated transcription, initiation
GFH35_RS03410	COG0745	RESPONSE REGULATOR receiver
GFH35_RS03410	COG2205	protein histidine kinase activity
GFH35_RS03410	COG3292	Two component regulator propeller
GFH35_RS03500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH35_RS03500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH35_RS03505	COG0551	DNA topoisomerase type I activity
GFH35_RS03505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFH35_RS03575	COG3344	reverse transcriptase
GFH35_RS03670	COG4974	Belongs to the 'phage' integrase family
GFH35_RS03680	COG1882	Formate acetyltransferase
GFH35_RS03685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GFH35_RS03690	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS03720	COG4680	protein conserved in bacteria
GFH35_RS03740	COG2271	Major facilitator Superfamily
GFH35_RS03745	COG0584	glycerophosphoryl diester phosphodiesterase
GFH35_RS03755	COG0702	epimerase
GFH35_RS03760	COG4771	TonB-dependent receptor
GFH35_RS03765	COG1629	transport
GFH35_RS03790	COG0584	glycerophosphoryl diester phosphodiesterase
GFH35_RS03795	COG0584	glycerophosphoryl diester phosphodiesterase
GFH35_RS03805	COG4771	TonB-dependent receptor
GFH35_RS03820	COG1595	DNA-templated transcription, initiation
GFH35_RS03840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFH35_RS03850	COG0583	DNA-binding transcription factor activity
GFH35_RS03855	COG0783	Belongs to the Dps family
GFH35_RS03875	COG4206	TonB-dependent receptor
GFH35_RS03875	COG1629	transport
GFH35_RS03890	COG1191	sigma factor activity
GFH35_RS03900	COG4948	Mandelate Racemase Muconate Lactonizing
GFH35_RS03905	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GFH35_RS03910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GFH35_RS03915	COG1169	isochorismate synthase
GFH35_RS03920	COG0561	phosphatase activity
GFH35_RS03925	COG3189	MarR family transcriptional regulator
GFH35_RS03935	COG0456	acetyltransferase
GFH35_RS03940	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GFH35_RS03950	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GFH35_RS03975	COG1132	(ABC) transporter
GFH35_RS04005	COG2885	chlorophyll binding
GFH35_RS04055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFH35_RS04060	COG0438	transferase activity, transferring glycosyl groups
GFH35_RS04085	COG1216	Glycosyl transferase, family 2
GFH35_RS04090	COG1216	Glycosyl transferase, family 2
GFH35_RS04095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFH35_RS04100	COG0438	transferase activity, transferring glycosyl groups
GFH35_RS04110	COG1216	Glycosyl transferase, family 2
GFH35_RS04110	COG1442	glycosyl transferase family 8
GFH35_RS04140	COG3344	reverse transcriptase
GFH35_RS04190	COG1629	transport
GFH35_RS04190	COG4206	TonB-dependent receptor
GFH35_RS04250	COG5002	protein histidine kinase activity
GFH35_RS04250	COG2198	Histidine kinase
GFH35_RS04250	COG0784	Response regulator, receiver
GFH35_RS04295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFH35_RS04340	COG0584	glycerophosphoryl diester phosphodiesterase
GFH35_RS04360	COG1475	DNA binding
GFH35_RS04465	COG3344	reverse transcriptase
GFH35_RS04480	COG3344	reverse transcriptase
GFH35_RS04545	COG0464	growth
GFH35_RS04585	COG0582	viral genome integration into host DNA
GFH35_RS04625	COG5290	Psort location Cytoplasmic, score
GFH35_RS04650	COG4974	Belongs to the 'phage' integrase family
GFH35_RS04660	COG1193	negative regulation of DNA recombination
GFH35_RS04665	COG0598	Magnesium transport protein CorA
GFH35_RS04670	COG1760	l-serine dehydratase
GFH35_RS04690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFH35_RS04715	COG3754	Rhamnan synthesis protein F
GFH35_RS04755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH35_RS04785	COG4974	Belongs to the 'phage' integrase family
GFH35_RS04800	COG3250	beta-galactosidase activity
GFH35_RS04810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFH35_RS04815	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GFH35_RS04820	COG0745	RESPONSE REGULATOR receiver
GFH35_RS04820	COG3292	Two component regulator propeller
GFH35_RS04820	COG2205	protein histidine kinase activity
GFH35_RS04825	COG5434	Belongs to the glycosyl hydrolase 28 family
GFH35_RS04835	COG4771	TonB-dependent receptor
GFH35_RS04840	COG0702	epimerase
GFH35_RS04845	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH35_RS04855	COG3119	arylsulfatase activity
GFH35_RS04865	COG1940	carbohydrate kinase activity
GFH35_RS04880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GFH35_RS04895	COG0038	chloride channel
GFH35_RS04960	COG0586	Pfam SNARE associated Golgi protein
GFH35_RS04970	COG0306	phosphate transporter
GFH35_RS04975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFH35_RS04975	COG4651	solute:proton antiporter activity
GFH35_RS05020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFH35_RS05090	COG0443	Heat shock 70 kDa protein
GFH35_RS05110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFH35_RS05115	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFH35_RS05120	COG2855	membrane
GFH35_RS05125	COG3304	Inner membrane component domain
GFH35_RS05130	COG1373	ATPase (AAA superfamily
GFH35_RS05145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH35_RS05210	COG0583	DNA-binding transcription factor activity
GFH35_RS05225	COG0542	response to heat
GFH35_RS05240	COG0237	dephospho-CoA kinase activity
GFH35_RS05255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFH35_RS05265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GFH35_RS05270	COG0193	aminoacyl-tRNA hydrolase activity
GFH35_RS05275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GFH35_RS05285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFH35_RS05285	COG4651	solute:proton antiporter activity
GFH35_RS05290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFH35_RS05295	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFH35_RS05300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFH35_RS05305	COG1082	Xylose isomerase domain protein TIM barrel
GFH35_RS05310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFH35_RS05320	COG0148	phosphopyruvate hydratase activity
GFH35_RS05340	COG0463	Glycosyl transferase, family 2
GFH35_RS05355	COG1971	Probably functions as a manganese efflux pump
GFH35_RS05360	COG1477	protein flavinylation
GFH35_RS05370	COG0037	tRNA processing
GFH35_RS05385	COG4864	UPF0365 protein
GFH35_RS05395	COG0702	epimerase
GFH35_RS05400	COG2205	protein histidine kinase activity
GFH35_RS05400	COG0784	Response regulator, receiver
GFH35_RS05405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GFH35_RS05420	COG1063	alcohol dehydrogenase
GFH35_RS05435	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GFH35_RS05465	COG0582	viral genome integration into host DNA
GFH35_RS05480	COG1396	sequence-specific DNA binding
GFH35_RS05530	COG0346	lactoylglutathione lyase activity
GFH35_RS05560	COG0564	pseudouridine synthase activity
GFH35_RS05565	COG0534	Mate efflux family protein
GFH35_RS05615	COG1388	LysM domain
GFH35_RS05615	COG0741	lytic transglycosylase activity
GFH35_RS05620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFH35_RS05635	COG1285	pathogenesis
GFH35_RS05665	COG0776	regulation of translation
GFH35_RS05675	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS05710	COG1115	amino acid carrier protein
GFH35_RS05720	COG1509	lysine 2,3-aminomutase activity
GFH35_RS05725	COG2233	PERMEase
GFH35_RS05740	COG4771	TonB-dependent receptor
GFH35_RS05750	COG1393	Belongs to the ArsC family
GFH35_RS05760	COG2304	oxidoreductase activity
GFH35_RS05770	COG4589	Belongs to the CDS family
GFH35_RS05790	COG0351	phosphomethylpyrimidine kinase
GFH35_RS05800	COG1139	Iron-sulfur cluster binding protein
GFH35_RS05805	COG0247	lactate metabolic process
GFH35_RS05810	COG0602	queuosine metabolic process
GFH35_RS05820	COG2832	Protein of unknown function (DUF454)
GFH35_RS05825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GFH35_RS05840	COG1063	alcohol dehydrogenase
GFH35_RS05850	COG0246	Mannitol dehydrogenase
GFH35_RS05880	COG0702	epimerase
GFH35_RS05885	COG4771	TonB-dependent receptor
GFH35_RS05920	COG1418	mRNA catabolic process
GFH35_RS05925	COG3142	Participates in the control of copper homeostasis
GFH35_RS05965	COG4804	nuclease activity
GFH35_RS05975	COG2706	6-phosphogluconolactonase activity
GFH35_RS05990	COG1496	oxidoreductase activity
GFH35_RS05995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFH35_RS06000	COG0563	adenylate kinase activity
GFH35_RS06005	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GFH35_RS06020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GFH35_RS06020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFH35_RS06060	COG2204	response regulator
GFH35_RS06065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GFH35_RS06075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GFH35_RS06085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFH35_RS06090	COG1253	flavin adenine dinucleotide binding
GFH35_RS06110	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GFH35_RS06125	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
GFH35_RS06130	COG0653	protein targeting
GFH35_RS06155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH35_RS06160	COG4206	TonB-dependent receptor
GFH35_RS06160	COG1629	transport
GFH35_RS06180	COG0525	valine-tRNA ligase activity
GFH35_RS06230	COG3956	TIGRFAM MazG family protein
GFH35_RS06250	COG2989	Protein conserved in bacteria
GFH35_RS06255	COG1234	tRNA 3'-trailer cleavage
GFH35_RS06310	COG4206	TonB-dependent receptor
GFH35_RS06310	COG1629	transport
GFH35_RS06350	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH35_RS06355	COG0492	ferredoxin-NADP+ reductase activity
GFH35_RS06365	COG1674	ftsk spoiiie
GFH35_RS06380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GFH35_RS06385	COG2211	Major facilitator Superfamily
GFH35_RS06405	COG1136	(ABC) transporter
GFH35_RS06420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFH35_RS06425	COG1597	lipid kinase activity
GFH35_RS06430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GFH35_RS06435	COG0612	Peptidase, M16
GFH35_RS06450	COG0791	NLP P60 protein
GFH35_RS06465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFH35_RS06470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFH35_RS06475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFH35_RS06480	COG0543	2 iron, 2 sulfur cluster binding
GFH35_RS06485	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GFH35_RS06490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GFH35_RS06495	COG0297	glycogen (starch) synthase activity
GFH35_RS06510	COG0297	glycogen (starch) synthase activity
GFH35_RS06535	COG0519	Catalyzes the synthesis of GMP from XMP
GFH35_RS06535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFH35_RS06540	COG1970	mechanosensitive ion channel activity
GFH35_RS06550	COG0339	signal peptide processing
GFH35_RS06560	COG2131	deaminase
GFH35_RS06565	COG0793	Belongs to the peptidase S41A family
GFH35_RS06570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFH35_RS06585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFH35_RS06595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFH35_RS06610	COG0673	inositol 2-dehydrogenase activity
GFH35_RS06615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFH35_RS06620	COG3250	beta-galactosidase activity
GFH35_RS06640	COG0101	tRNA pseudouridine synthase activity
GFH35_RS06650	COG2268	Band 7 protein
GFH35_RS06675	COG1702	phosphate starvation-inducible protein PhoH
GFH35_RS06680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFH35_RS06685	COG2226	methyltransferase
GFH35_RS06690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFH35_RS06715	COG1704	LemA family
GFH35_RS06720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFH35_RS06725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFH35_RS06730	COG0284	orotidine-5'-phosphate decarboxylase activity
GFH35_RS06735	COG1078	dGTPase activity
GFH35_RS06740	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH35_RS06745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFH35_RS06745	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GFH35_RS06760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFH35_RS06780	COG0823	Involved in the tonB-independent uptake of proteins
GFH35_RS06780	COG1506	peptidase
GFH35_RS06785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFH35_RS06795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFH35_RS06805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GFH35_RS06835	COG0546	phosphoglycolate phosphatase activity
GFH35_RS06855	COG0745	RESPONSE REGULATOR receiver
GFH35_RS06855	COG2205	protein histidine kinase activity
GFH35_RS06855	COG2205	protein histidine kinase activity
GFH35_RS06855	COG0745	RESPONSE REGULATOR receiver
GFH35_RS06855	COG3292	Two component regulator propeller
GFH35_RS06855	COG3292	Two component regulator propeller
GFH35_RS06920	COG4771	TonB-dependent receptor
GFH35_RS06935	COG0702	epimerase
GFH35_RS06940	COG4771	TonB-dependent receptor
GFH35_RS06960	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH35_RS06975	COG3401	FG-GAP repeat protein
GFH35_RS07000	COG1629	transport
GFH35_RS07035	COG0582	viral genome integration into host DNA
GFH35_RS07045	COG3292	Two component regulator propeller
GFH35_RS07045	COG2205	protein histidine kinase activity
GFH35_RS07045	COG0745	RESPONSE REGULATOR receiver
GFH35_RS07080	COG3250	beta-galactosidase activity
GFH35_RS07100	COG0745	RESPONSE REGULATOR receiver
GFH35_RS07100	COG3292	Two component regulator propeller
GFH35_RS07100	COG0745	RESPONSE REGULATOR receiver
GFH35_RS07100	COG2205	protein histidine kinase activity
GFH35_RS07100	COG3292	Two component regulator propeller
GFH35_RS07100	COG2205	protein histidine kinase activity
GFH35_RS07105	COG3254	rhamnose metabolic process
GFH35_RS07115	COG3401	FG-GAP repeat protein
GFH35_RS07125	COG2755	lipolytic protein G-D-S-L family
GFH35_RS07140	COG3401	FG-GAP repeat protein
GFH35_RS07150	COG1629	transport
GFH35_RS07160	COG4771	TonB-dependent receptor
GFH35_RS07180	COG1629	transport
GFH35_RS07185	COG0702	epimerase
GFH35_RS07215	COG2755	lipolytic protein G-D-S-L family
GFH35_RS07240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GFH35_RS07245	COG0561	phosphatase activity
GFH35_RS07250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH35_RS07260	COG0009	L-threonylcarbamoyladenylate synthase
GFH35_RS07265	COG0363	glucosamine-6-phosphate deaminase activity
GFH35_RS07275	COG1242	4 iron, 4 sulfur cluster binding
GFH35_RS07280	COG3279	Response regulator of the LytR AlgR family
GFH35_RS07300	COG4771	TonB-dependent receptor
GFH35_RS07305	COG0702	epimerase
GFH35_RS07315	COG0745	RESPONSE REGULATOR receiver
GFH35_RS07315	COG2205	protein histidine kinase activity
GFH35_RS07315	COG3292	Two component regulator propeller
GFH35_RS07325	COG2755	lipolytic protein G-D-S-L family
GFH35_RS07340	COG3775	system Galactitol-specific IIC component
GFH35_RS07345	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GFH35_RS07350	COG2271	Major facilitator Superfamily
GFH35_RS07365	COG0805	protein transport
GFH35_RS07370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFH35_RS07375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFH35_RS07395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFH35_RS07400	COG0569	domain protein
GFH35_RS07405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFH35_RS07420	COG3537	Alpha-1,2-mannosidase
GFH35_RS07450	COG4771	TonB-dependent receptor
GFH35_RS07455	COG0702	epimerase
GFH35_RS07460	COG4771	TonB-dependent receptor
GFH35_RS07475	COG3250	beta-galactosidase activity
GFH35_RS07485	COG3250	beta-galactosidase activity
GFH35_RS07520	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH35_RS07525	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH35_RS07530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH35_RS07530	COG0649	NAD binding
GFH35_RS07535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GFH35_RS07550	COG0713	ATP synthesis coupled electron transport
GFH35_RS07555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH35_RS07560	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH35_RS07570	COG0784	Response regulator, receiver
GFH35_RS07570	COG2198	Histidine kinase
GFH35_RS07570	COG5002	protein histidine kinase activity
GFH35_RS07590	COG0662	Cupin 2, conserved barrel domain protein
GFH35_RS07590	COG2207	Transcriptional regulator
GFH35_RS07595	COG0668	transmembrane transport
GFH35_RS07635	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFH35_RS07645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFH35_RS07650	COG2239	Acts as a magnesium transporter
GFH35_RS07655	COG1196	nuclear chromosome segregation
GFH35_RS07690	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS07745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFH35_RS07750	COG4589	Belongs to the CDS family
GFH35_RS07760	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH35_RS07765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GFH35_RS07770	COG1192	Involved in chromosome partitioning
GFH35_RS07775	COG1475	DNA binding
GFH35_RS07785	COG0741	lytic transglycosylase activity
GFH35_RS07785	COG1388	LysM domain
GFH35_RS07790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFH35_RS07800	COG0739	heme binding
GFH35_RS07805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFH35_RS07825	COG3537	Alpha-1,2-mannosidase
GFH35_RS07830	COG3537	Alpha-1,2-mannosidase
GFH35_RS07865	COG4771	TonB-dependent receptor
GFH35_RS07875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH35_RS07890	COG0742	ribosomal rna small subunit methyltransferase
GFH35_RS07895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFH35_RS07910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFH35_RS07920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFH35_RS07955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFH35_RS07965	COG0386	Belongs to the glutathione peroxidase family
GFH35_RS07980	COG3275	phosphorelay sensor kinase activity
GFH35_RS07985	COG3279	Response regulator of the LytR AlgR family
GFH35_RS07995	COG4948	Mandelate Racemase Muconate Lactonizing
GFH35_RS08000	COG3537	Alpha-1,2-mannosidase
GFH35_RS08010	COG3537	Alpha-1,2-mannosidase
GFH35_RS08015	COG3537	Alpha-1,2-mannosidase
GFH35_RS08045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH35_RS08055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFH35_RS08060	COG2333	competence protein COMEC
GFH35_RS08060	COG0658	competence protein
GFH35_RS08065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFH35_RS08070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFH35_RS08080	COG0009	L-threonylcarbamoyladenylate synthase
GFH35_RS08090	COG1785	Belongs to the alkaline phosphatase family
GFH35_RS08110	COG0702	epimerase
GFH35_RS08115	COG4771	TonB-dependent receptor
GFH35_RS08130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFH35_RS08130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFH35_RS08135	COG0514	ATP-dependent DNA helicase (RecQ)
GFH35_RS08160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GFH35_RS08170	COG0358	DNA primase activity
GFH35_RS08175	COG0302	gtp cyclohydrolase
GFH35_RS08185	COG0149	triose-phosphate isomerase activity
GFH35_RS08200	COG0739	heme binding
GFH35_RS08205	COG0105	UTP biosynthetic process
GFH35_RS08210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFH35_RS08215	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GFH35_RS08230	COG0848	biopolymer transport protein
GFH35_RS08235	COG0811	peptide transport
GFH35_RS08240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GFH35_RS08245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFH35_RS08280	COG4771	TonB-dependent receptor
GFH35_RS08295	COG0039	L-malate dehydrogenase activity
GFH35_RS08335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH35_RS08345	COG0489	protein tyrosine kinase activity
GFH35_RS08350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFH35_RS08360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFH35_RS08370	COG1570	exodeoxyribonuclease VII activity
GFH35_RS08380	COG0482	sulfurtransferase activity
GFH35_RS08395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GFH35_RS08400	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFH35_RS08405	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GFH35_RS08420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GFH35_RS08425	COG0052	Belongs to the universal ribosomal protein uS2 family
GFH35_RS08430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFH35_RS08435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFH35_RS08440	COG0702	epimerase
GFH35_RS08445	COG4771	TonB-dependent receptor
GFH35_RS08480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH35_RS08490	COG0017	Asparaginyl-tRNA synthetase
GFH35_RS08495	COG1187	pseudouridine synthase activity
GFH35_RS08515	COG0110	maltose O-acetyltransferase activity
GFH35_RS08520	COG3022	response to hydroperoxide
GFH35_RS08560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFH35_RS08575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFH35_RS08585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFH35_RS08590	COG0516	GMP reductase activity
GFH35_RS08590	COG0517	IMP dehydrogenase activity
GFH35_RS08595	COG0514	ATP-dependent DNA helicase (RecQ)
GFH35_RS08600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFH35_RS08605	COG0740	serine-type endopeptidase activity
GFH35_RS08610	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFH35_RS08615	COG0724	RNA recognition motif
GFH35_RS08620	COG1127	ABC transporter
GFH35_RS08625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GFH35_RS08635	COG1160	GTP binding
GFH35_RS08640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFH35_RS08645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFH35_RS08715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GFH35_RS08720	COG0470	DNA polymerase III
GFH35_RS08725	COG1774	PSP1 C-terminal conserved region
GFH35_RS08735	COG0772	Belongs to the SEDS family
GFH35_RS08760	COG0138	bifunctional purine biosynthesis protein purh
GFH35_RS08765	COG3590	peptidase
GFH35_RS08770	COG0488	(ABC) transporter
GFH35_RS08790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH35_RS08795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH35_RS08795	COG2205	protein histidine kinase activity
GFH35_RS08800	COG0534	Mate efflux family protein
GFH35_RS08810	COG0612	Peptidase, M16
GFH35_RS08815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFH35_RS08815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFH35_RS08820	COG2204	response regulator
GFH35_RS08825	COG3119	arylsulfatase activity
GFH35_RS08845	COG4771	TonB-dependent receptor
GFH35_RS08865	COG2205	protein histidine kinase activity
GFH35_RS08865	COG3292	Two component regulator propeller
GFH35_RS08865	COG0745	RESPONSE REGULATOR receiver
GFH35_RS08870	COG3537	Alpha-1,2-mannosidase
GFH35_RS08900	COG0564	pseudouridine synthase activity
GFH35_RS08935	COG3250	beta-galactosidase activity
GFH35_RS08940	COG1501	Belongs to the glycosyl hydrolase 31 family
GFH35_RS08970	COG0702	epimerase
GFH35_RS08975	COG4771	TonB-dependent receptor
GFH35_RS08980	COG0745	RESPONSE REGULATOR receiver
GFH35_RS08980	COG2205	protein histidine kinase activity
GFH35_RS08980	COG3292	Two component regulator propeller
GFH35_RS08990	COG1454	alcohol dehydrogenase
GFH35_RS08995	COG0235	Class ii aldolase
GFH35_RS09005	COG4806	L-rhamnose isomerase
GFH35_RS09010	COG1070	Carbohydrate kinase
GFH35_RS09015	COG1438	arginine binding
GFH35_RS09025	COG0137	argininosuccinate synthase activity
GFH35_RS09030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GFH35_RS09040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFH35_RS09050	COG1396	sequence-specific DNA binding
GFH35_RS09050	COG1917	Cupin 2, conserved barrel domain protein
GFH35_RS09055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFH35_RS09115	COG4771	TonB-dependent receptor
GFH35_RS09145	COG1629	transport
GFH35_RS09145	COG4206	TonB-dependent receptor
GFH35_RS09170	COG0165	Argininosuccinate lyase
GFH35_RS09180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFH35_RS09190	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH35_RS09195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH35_RS09195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFH35_RS09205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFH35_RS09210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GFH35_RS09225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFH35_RS09235	COG0436	Aminotransferase
GFH35_RS09240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFH35_RS09245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFH35_RS09250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFH35_RS09280	COG0564	pseudouridine synthase activity
GFH35_RS09285	COG2815	serine threonine protein kinase
GFH35_RS09285	COG0515	serine threonine protein kinase
GFH35_RS09290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GFH35_RS09295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFH35_RS09300	COG1785	Belongs to the alkaline phosphatase family
GFH35_RS09310	COG0366	Alpha amylase catalytic
GFH35_RS09315	COG1082	Xylose isomerase domain protein TIM barrel
GFH35_RS09320	COG4206	TonB-dependent receptor
GFH35_RS09320	COG1629	transport
GFH35_RS09325	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH35_RS09450	COG3344	reverse transcriptase
GFH35_RS09565	COG1475	DNA binding
GFH35_RS09605	COG1629	transport
GFH35_RS09625	COG1501	Belongs to the glycosyl hydrolase 31 family
GFH35_RS09630	COG1082	Xylose isomerase domain protein TIM barrel
GFH35_RS09635	COG2205	protein histidine kinase activity
GFH35_RS09635	COG0784	Response regulator, receiver
GFH35_RS09670	COG1040	competence protein
GFH35_RS09695	COG4974	Belongs to the 'phage' integrase family
GFH35_RS09710	COG2003	Belongs to the UPF0758 family
GFH35_RS09715	COG0463	Glycosyl transferase, family 2
GFH35_RS09715	COG1216	Glycosyl transferase, family 2
GFH35_RS09730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GFH35_RS09735	COG0280	phosphate acetyltransferase
GFH35_RS09740	COG1380	Effector of murein hydrolase LrgA
GFH35_RS09745	COG1346	cytolysis
GFH35_RS09770	COG1082	Xylose isomerase domain protein TIM barrel
GFH35_RS09790	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GFH35_RS09795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFH35_RS09800	COG5002	protein histidine kinase activity
GFH35_RS09800	COG0784	Response regulator, receiver
GFH35_RS09805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFH35_RS09815	COG0733	neurotransmitter:sodium symporter activity
GFH35_RS09825	COG1136	(ABC) transporter
GFH35_RS09830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GFH35_RS09835	COG0475	glutathione-regulated potassium exporter activity
GFH35_RS09835	COG0589	response to stress
GFH35_RS09840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GFH35_RS09895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH35_RS09900	COG0463	Glycosyl transferase, family 2
GFH35_RS09900	COG1216	Glycosyl transferase, family 2
GFH35_RS09910	COG2211	Major facilitator Superfamily
GFH35_RS09920	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFH35_RS09935	COG0745	RESPONSE REGULATOR receiver
GFH35_RS09935	COG3292	Two component regulator propeller
GFH35_RS09935	COG2205	protein histidine kinase activity
GFH35_RS09940	COG3507	Belongs to the glycosyl hydrolase 43 family
GFH35_RS09945	COG2382	esterase
GFH35_RS09975	COG1629	transport
GFH35_RS09985	COG4771	TonB-dependent receptor
GFH35_RS09990	COG3507	Belongs to the glycosyl hydrolase 43 family
GFH35_RS09995	COG3507	Belongs to the glycosyl hydrolase 43 family
GFH35_RS10005	COG1501	Belongs to the glycosyl hydrolase 31 family
GFH35_RS10010	COG3507	Belongs to the glycosyl hydrolase 43 family
GFH35_RS10015	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH35_RS10025	COG1063	alcohol dehydrogenase
GFH35_RS10030	COG0738	Major facilitator superfamily
GFH35_RS10045	COG1609	Transcriptional regulator
GFH35_RS10060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFH35_RS10060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GFH35_RS10075	COG0423	glycine-tRNA ligase activity
GFH35_RS10085	COG1609	Transcriptional regulator
GFH35_RS10085	COG2207	Transcriptional regulator
GFH35_RS10095	COG1629	transport
GFH35_RS10115	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH35_RS10125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GFH35_RS10130	COG0363	glucosamine-6-phosphate deaminase activity
GFH35_RS10150	COG0673	inositol 2-dehydrogenase activity
GFH35_RS10155	COG0673	inositol 2-dehydrogenase activity
GFH35_RS10160	COG1595	DNA-templated transcription, initiation
GFH35_RS10195	COG1629	transport
GFH35_RS10205	COG2271	Major facilitator Superfamily
GFH35_RS10235	COG4771	TonB-dependent receptor
GFH35_RS10240	COG0561	phosphatase activity
GFH35_RS10275	COG1864	DNA RNA non-specific endonuclease
GFH35_RS10275	COG3591	Belongs to the peptidase S1B family
GFH35_RS10310	COG2954	triphosphatase activity
GFH35_RS10330	COG1022	Amp-dependent synthetase and ligase
GFH35_RS10365	COG1595	DNA-templated transcription, initiation
GFH35_RS10370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH35_RS10375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH35_RS10425	COG3537	Alpha-1,2-mannosidase
GFH35_RS10450	COG0702	epimerase
GFH35_RS10455	COG4206	TonB-dependent receptor
GFH35_RS10455	COG1629	transport
GFH35_RS10485	COG3408	Glycogen debranching enzyme
GFH35_RS10485	COG3119	arylsulfatase activity
GFH35_RS10500	COG3119	arylsulfatase activity
GFH35_RS10535	COG4942	peptidase
GFH35_RS10550	COG0756	dUTP diphosphatase activity
GFH35_RS10580	COG4771	TonB-dependent receptor
GFH35_RS10590	COG3940	Belongs to the glycosyl hydrolase 43 family
GFH35_RS10595	COG2205	protein histidine kinase activity
GFH35_RS10595	COG3292	Two component regulator propeller
GFH35_RS10595	COG0745	RESPONSE REGULATOR receiver
GFH35_RS10595	COG3292	Two component regulator propeller
GFH35_RS10595	COG2205	protein histidine kinase activity
GFH35_RS10595	COG0745	RESPONSE REGULATOR receiver
GFH35_RS10600	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GFH35_RS10615	COG1595	DNA-templated transcription, initiation
GFH35_RS10620	COG2001	Belongs to the MraZ family
GFH35_RS10625	COG0275	rRNA processing
GFH35_RS10640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFH35_RS10645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH35_RS10650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFH35_RS10655	COG0772	Belongs to the SEDS family
GFH35_RS10660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFH35_RS10665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFH35_RS10680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFH35_RS10755	COG1381	Involved in DNA repair and RecF pathway recombination
GFH35_RS10765	COG0268	Binds directly to 16S ribosomal RNA
GFH35_RS10770	COG0187	DNA topoisomerase II activity
GFH35_RS10785	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GFH35_RS10800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFH35_RS10805	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GFH35_RS10810	COG2205	protein histidine kinase activity
GFH35_RS10810	COG0745	RESPONSE REGULATOR receiver
GFH35_RS10810	COG3292	Two component regulator propeller
GFH35_RS10810	COG2205	protein histidine kinase activity
GFH35_RS10810	COG3292	Two component regulator propeller
GFH35_RS10810	COG0745	RESPONSE REGULATOR receiver
GFH35_RS10825	COG0393	Putative heavy-metal-binding
GFH35_RS10830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFH35_RS10835	COG0719	Fe-S assembly protein
GFH35_RS10840	COG0396	ATPase activity
GFH35_RS10845	COG0719	Fe-S assembly protein
GFH35_RS10855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFH35_RS10860	COG0195	Participates in both transcription termination and antitermination
GFH35_RS10865	COG0779	Required for maturation of 30S ribosomal subunits
GFH35_RS10910	COG1595	DNA-templated transcription, initiation
GFH35_RS10915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFH35_RS10920	COG1166	arginine decarboxylase activity
GFH35_RS10930	COG0326	Molecular chaperone. Has ATPase activity
GFH35_RS10940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GFH35_RS10950	COG0328	RNA-DNA hybrid ribonuclease activity
GFH35_RS10950	COG3341	Caulimovirus viroplasmin
GFH35_RS10960	COG1368	sulfuric ester hydrolase activity
GFH35_RS10970	COG0463	Glycosyl transferase, family 2
GFH35_RS10980	COG1132	(ABC) transporter
GFH35_RS11050	COG1442	glycosyl transferase family 8
GFH35_RS11050	COG1216	Glycosyl transferase, family 2
GFH35_RS11055	COG1216	Glycosyl transferase, family 2
GFH35_RS11070	COG1216	Glycosyl transferase, family 2
GFH35_RS11070	COG1442	glycosyl transferase family 8
GFH35_RS11085	COG4750	Nucleotidyl transferase
GFH35_RS11090	COG3475	LICD family
GFH35_RS11095	COG0438	transferase activity, transferring glycosyl groups
GFH35_RS11130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH35_RS11140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH35_RS11145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFH35_RS11150	COG0571	ribonuclease III activity
GFH35_RS11155	COG0205	6-phosphofructokinase activity
GFH35_RS11165	COG0482	sulfurtransferase activity
GFH35_RS11185	COG0561	phosphatase activity
GFH35_RS11190	COG0215	cysteine-tRNA ligase activity
GFH35_RS11195	COG5492	domain, Protein
GFH35_RS11200	COG3119	arylsulfatase activity
GFH35_RS11205	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH35_RS11215	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GFH35_RS11220	COG3507	Belongs to the glycosyl hydrolase 43 family
GFH35_RS11225	COG0702	epimerase
GFH35_RS11230	COG4206	TonB-dependent receptor
GFH35_RS11230	COG1629	transport
GFH35_RS11280	COG3250	beta-galactosidase activity
GFH35_RS11285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH35_RS11295	COG1538	Outer membrane efflux protein
GFH35_RS11300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFH35_RS11310	COG1609	Transcriptional regulator
GFH35_RS11320	COG3250	beta-galactosidase activity
GFH35_RS11325	COG1940	carbohydrate kinase activity
GFH35_RS11340	COG0738	Major facilitator superfamily
GFH35_RS11360	COG1629	transport
GFH35_RS11370	COG4206	TonB-dependent receptor
GFH35_RS11370	COG1629	transport
GFH35_RS11375	COG0702	epimerase
GFH35_RS11390	COG0745	RESPONSE REGULATOR receiver
GFH35_RS11390	COG2205	protein histidine kinase activity
GFH35_RS11390	COG3292	Two component regulator propeller
GFH35_RS11390	COG0745	RESPONSE REGULATOR receiver
GFH35_RS11390	COG2205	protein histidine kinase activity
GFH35_RS11390	COG3292	Two component regulator propeller
GFH35_RS11395	COG3119	arylsulfatase activity
GFH35_RS11400	COG4771	TonB-dependent receptor
GFH35_RS11405	COG0702	epimerase
GFH35_RS11415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFH35_RS11425	COG5492	domain, Protein
GFH35_RS11445	COG1215	transferase activity, transferring glycosyl groups
GFH35_RS11475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFH35_RS11485	COG0681	Belongs to the peptidase S26 family
GFH35_RS11530	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH35_RS11545	COG0702	epimerase
GFH35_RS11550	COG4771	TonB-dependent receptor
GFH35_RS11560	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
GFH35_RS11580	COG1595	DNA-templated transcription, initiation
GFH35_RS11590	COG4771	TonB-dependent receptor
GFH35_RS11595	COG0702	epimerase
GFH35_RS11615	COG0584	glycerophosphoryl diester phosphodiesterase
GFH35_RS11625	COG0612	Peptidase, M16
GFH35_RS11640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH35_RS11665	COG0513	Belongs to the DEAD box helicase family
GFH35_RS11670	COG3591	Belongs to the peptidase S1B family
GFH35_RS11690	COG2255	four-way junction helicase activity
GFH35_RS11695	COG2715	membrane protein required for spore maturation
GFH35_RS11700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFH35_RS11740	COG4771	TonB-dependent receptor
GFH35_RS11755	COG0445	tRNA wobble uridine modification
GFH35_RS11760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFH35_RS11765	COG0322	excinuclease ABC activity
GFH35_RS11770	COG1490	D-aminoacyl-tRNA deacylase activity
GFH35_RS11775	COG1694	Mazg nucleotide pyrophosphohydrolase
GFH35_RS11780	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFH35_RS11790	COG0142	geranyltranstransferase activity
GFH35_RS11795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFH35_RS11795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFH35_RS11805	COG3279	Response regulator of the LytR AlgR family
GFH35_RS11815	COG1045	serine acetyltransferase
GFH35_RS11820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GFH35_RS11820	COG0116	Belongs to the methyltransferase superfamily
GFH35_RS11830	COG1506	peptidase
GFH35_RS11830	COG0823	Involved in the tonB-independent uptake of proteins
GFH35_RS11845	COG1238	metal cluster binding
GFH35_RS11850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFH35_RS11850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GFH35_RS11860	COG1121	(ABC) transporter
GFH35_RS11870	COG0726	polysaccharide deacetylase
GFH35_RS11905	COG1028	Short-chain dehydrogenase reductase Sdr
GFH35_RS11910	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GFH35_RS11920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFH35_RS11930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GFH35_RS11935	COG0594	ribonuclease P activity
GFH35_RS11950	COG1611	Belongs to the LOG family
GFH35_RS11985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFH35_RS11995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GFH35_RS12000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFH35_RS12005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFH35_RS12010	COG1968	undecaprenyl-diphosphatase activity
GFH35_RS12020	COG2177	Part of the ABC transporter FtsEX involved in
GFH35_RS12040	COG3209	COG3209 Rhs family protein
GFH35_RS12055	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS12080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH35_RS12090	COG0427	acetyl-CoA hydrolase
GFH35_RS12095	COG2027	D-alanyl-D-alanine carboxypeptidase
GFH35_RS12125	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GFH35_RS12140	COG4771	TonB-dependent receptor
GFH35_RS12150	COG3292	Two component regulator propeller
GFH35_RS12150	COG2205	protein histidine kinase activity
GFH35_RS12150	COG2205	protein histidine kinase activity
GFH35_RS12150	COG0745	RESPONSE REGULATOR receiver
GFH35_RS12150	COG3292	Two component regulator propeller
GFH35_RS12150	COG0745	RESPONSE REGULATOR receiver
GFH35_RS12225	COG0358	DNA primase activity
GFH35_RS12300	COG3344	reverse transcriptase
GFH35_RS12375	COG0577	efflux transmembrane transporter activity
GFH35_RS12395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH35_RS12410	COG3344	reverse transcriptase
GFH35_RS12425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFH35_RS12425	COG0551	DNA topoisomerase type I activity
GFH35_RS12460	COG4974	Belongs to the 'phage' integrase family
GFH35_RS12475	COG1592	Rubrerythrin
GFH35_RS12480	COG0659	secondary active sulfate transmembrane transporter activity
GFH35_RS12485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH35_RS12500	COG4206	TonB-dependent receptor
GFH35_RS12500	COG1629	transport
GFH35_RS12535	COG2205	protein histidine kinase activity
GFH35_RS12535	COG0745	RESPONSE REGULATOR receiver
GFH35_RS12535	COG0745	RESPONSE REGULATOR receiver
GFH35_RS12535	COG3292	Two component regulator propeller
GFH35_RS12535	COG3292	Two component regulator propeller
GFH35_RS12535	COG2205	protein histidine kinase activity
GFH35_RS12585	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH35_RS12605	COG1629	transport
GFH35_RS12615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH35_RS12615	COG0784	Response regulator, receiver
GFH35_RS12615	COG2205	protein histidine kinase activity
GFH35_RS12615	COG2198	Histidine kinase
GFH35_RS12635	COG4771	TonB-dependent receptor
GFH35_RS12640	COG0702	epimerase
GFH35_RS12660	COG1247	-acetyltransferase
GFH35_RS12675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFH35_RS12675	COG0731	radical SAM domain protein
GFH35_RS12705	COG4206	TonB-dependent receptor
GFH35_RS12705	COG1629	transport
GFH35_RS12735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFH35_RS12740	COG1360	Flagellar Motor Protein
GFH35_RS12745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFH35_RS12750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFH35_RS12755	COG0495	leucyl-tRNA aminoacylation
GFH35_RS12760	COG3408	Glycogen debranching enzyme
GFH35_RS12775	COG0697	spore germination
GFH35_RS12780	COG1785	Belongs to the alkaline phosphatase family
GFH35_RS12790	COG3537	Alpha-1,2-mannosidase
GFH35_RS12805	COG0582	viral genome integration into host DNA
GFH35_RS12865	COG4974	Belongs to the 'phage' integrase family
GFH35_RS13005	COG1629	transport
GFH35_RS13010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFH35_RS13015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFH35_RS13020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFH35_RS13025	COG0012	GTP binding
GFH35_RS13030	COG2814	Major facilitator Superfamily
GFH35_RS13040	COG3119	arylsulfatase activity
GFH35_RS13065	COG4206	TonB-dependent receptor
GFH35_RS13065	COG1629	transport
GFH35_RS13075	COG1629	transport
GFH35_RS13075	COG4206	TonB-dependent receptor
GFH35_RS13125	COG0745	RESPONSE REGULATOR receiver
GFH35_RS13125	COG2205	protein histidine kinase activity
GFH35_RS13125	COG3292	Two component regulator propeller
GFH35_RS13170	COG4771	TonB-dependent receptor
GFH35_RS13175	COG0702	epimerase
GFH35_RS13210	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GFH35_RS13215	COG4771	TonB-dependent receptor
GFH35_RS13220	COG0702	epimerase
GFH35_RS13240	COG4124	Belongs to the glycosyl hydrolase 26 family
GFH35_RS13250	COG1917	Cupin 2, conserved barrel domain protein
GFH35_RS13255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFH35_RS13260	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH35_RS13275	COG1629	transport
GFH35_RS13275	COG4206	TonB-dependent receptor
GFH35_RS13285	COG5002	protein histidine kinase activity
GFH35_RS13300	COG1629	transport
GFH35_RS13300	COG4206	TonB-dependent receptor
GFH35_RS13305	COG0702	epimerase
GFH35_RS13325	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH35_RS13335	COG0557	exoribonuclease II activity
GFH35_RS13370	COG4206	TonB-dependent receptor
GFH35_RS13370	COG1629	transport
GFH35_RS13395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFH35_RS13400	COG0826	peptidase U32
GFH35_RS13410	COG0758	DNA mediated transformation
GFH35_RS13520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GFH35_RS13525	COG1053	succinate dehydrogenase
GFH35_RS13545	COG0745	RESPONSE REGULATOR receiver
GFH35_RS13545	COG2205	protein histidine kinase activity
GFH35_RS13545	COG3292	Two component regulator propeller
GFH35_RS13550	COG1629	transport
GFH35_RS13550	COG4206	TonB-dependent receptor
GFH35_RS13555	COG0561	phosphatase activity
GFH35_RS13585	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH35_RS13590	COG3507	Belongs to the glycosyl hydrolase 43 family
GFH35_RS13595	COG4206	TonB-dependent receptor
GFH35_RS13595	COG1629	transport
GFH35_RS13610	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GFH35_RS13615	COG0745	RESPONSE REGULATOR receiver
GFH35_RS13615	COG2205	protein histidine kinase activity
GFH35_RS13615	COG3292	Two component regulator propeller
GFH35_RS13620	COG1501	Belongs to the glycosyl hydrolase 31 family
GFH35_RS13625	COG3250	beta-galactosidase activity
GFH35_RS13630	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH35_RS13635	COG3409	Peptidoglycan-binding domain 1 protein
GFH35_RS13635	COG0793	Belongs to the peptidase S41A family
GFH35_RS13640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFH35_RS13665	COG3408	Glycogen debranching enzyme
GFH35_RS13670	COG2211	Major facilitator Superfamily
GFH35_RS13675	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GFH35_RS13685	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GFH35_RS13695	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GFH35_RS13705	COG0702	epimerase
GFH35_RS13710	COG4771	TonB-dependent receptor
GFH35_RS13785	COG0561	phosphatase activity
GFH35_RS13805	COG0545	Peptidyl-prolyl cis-trans isomerase
GFH35_RS13810	COG0545	Peptidyl-prolyl cis-trans isomerase
GFH35_RS13815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFH35_RS13845	COG0438	transferase activity, transferring glycosyl groups
GFH35_RS13860	COG3475	LICD family
GFH35_RS13875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH35_RS13875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH35_RS13885	COG0673	inositol 2-dehydrogenase activity
GFH35_RS13890	COG0673	inositol 2-dehydrogenase activity
GFH35_RS13905	COG0745	RESPONSE REGULATOR receiver
GFH35_RS13905	COG3292	Two component regulator propeller
GFH35_RS13905	COG2205	protein histidine kinase activity
GFH35_RS13925	COG4771	TonB-dependent receptor
GFH35_RS13945	COG3507	Belongs to the glycosyl hydrolase 43 family
GFH35_RS13950	COG1501	Belongs to the glycosyl hydrolase 31 family
GFH35_RS13960	COG4771	TonB-dependent receptor
GFH35_RS13965	COG0702	epimerase
GFH35_RS13975	COG2205	protein histidine kinase activity
GFH35_RS13980	COG0606	chelatase, subunit chli
GFH35_RS13995	COG4974	Belongs to the 'phage' integrase family
GFH35_RS14015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFH35_RS14020	COG4591	ABC-type transport system involved in lipoprotein release permease component
GFH35_RS14035	COG4771	TonB-dependent receptor
GFH35_RS14075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH35_RS14080	COG3345	alpha-galactosidase
GFH35_RS14085	COG3458	cephalosporin-C deacetylase activity
GFH35_RS14090	COG3250	beta-galactosidase activity
GFH35_RS14100	COG1373	ATPase (AAA superfamily
GFH35_RS14110	COG4974	Belongs to the 'phage' integrase family
GFH35_RS14145	COG1196	nuclear chromosome segregation
GFH35_RS14145	COG0741	lytic transglycosylase activity
GFH35_RS14145	COG0739	heme binding
GFH35_RS14180	COG1629	transport
GFH35_RS14215	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GFH35_RS14225	COG3458	cephalosporin-C deacetylase activity
GFH35_RS14255	COG0622	Phosphoesterase
GFH35_RS14295	COG3344	reverse transcriptase
GFH35_RS14410	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFH35_RS14415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFH35_RS14415	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFH35_RS14425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFH35_RS14430	COG0339	signal peptide processing
GFH35_RS14445	COG0705	Rhomboid family
GFH35_RS14455	COG0018	arginyl-trna synthetase
GFH35_RS14475	COG0745	RESPONSE REGULATOR receiver
GFH35_RS14475	COG2205	protein histidine kinase activity
GFH35_RS14475	COG3292	Two component regulator propeller
GFH35_RS14500	COG1629	transport
GFH35_RS14525	COG3250	beta-galactosidase activity
GFH35_RS14535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GFH35_RS14550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GFH35_RS14615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH35_RS14675	COG4948	Mandelate Racemase Muconate Lactonizing
GFH35_RS14695	COG2816	NAD+ diphosphatase activity
GFH35_RS14705	COG3634	alkyl hydroperoxide reductase activity
GFH35_RS14725	COG3693	PFAM glycoside hydrolase, family 10
GFH35_RS14725	COG2382	esterase
GFH35_RS14755	COG4206	TonB-dependent receptor
GFH35_RS14755	COG1629	transport
GFH35_RS14760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH35_RS14765	COG1609	Transcriptional regulator
GFH35_RS14775	COG1629	transport
GFH35_RS14795	COG1929	Belongs to the glycerate kinase type-1 family
GFH35_RS14800	COG2610	gluconate transmembrane transporter activity
GFH35_RS14845	COG1040	competence protein
GFH35_RS14865	COG0662	Cupin 2, conserved barrel domain protein
GFH35_RS14865	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GFH35_RS14880	COG1396	sequence-specific DNA binding
GFH35_RS14885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFH35_RS14900	COG2059	Chromate
GFH35_RS14915	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GFH35_RS14920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFH35_RS14950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GFH35_RS14955	COG2205	protein histidine kinase activity
GFH35_RS14955	COG0784	Response regulator, receiver
GFH35_RS14955	COG5002	protein histidine kinase activity
GFH35_RS14960	COG0793	Belongs to the peptidase S41A family
GFH35_RS14965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH35_RS15015	COG2096	Adenosyltransferase
GFH35_RS15055	COG3940	Belongs to the glycosyl hydrolase 43 family
GFH35_RS15065	COG4206	TonB-dependent receptor
GFH35_RS15065	COG1629	transport
GFH35_RS15090	COG0584	glycerophosphoryl diester phosphodiesterase
GFH35_RS15095	COG0745	RESPONSE REGULATOR receiver
GFH35_RS15095	COG2205	protein histidine kinase activity
GFH35_RS15095	COG3292	Two component regulator propeller
GFH35_RS15100	COG4804	nuclease activity
GFH35_RS15130	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GFH35_RS15135	COG1027	Aspartate ammonia-lyase
GFH35_RS15140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH35_RS15165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFH35_RS15175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFH35_RS15185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFH35_RS15195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GFH35_RS15200	COG0006	proline dipeptidase activity
GFH35_RS15205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFH35_RS15210	COG4974	Belongs to the 'phage' integrase family
GFH35_RS15240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFH35_RS15250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFH35_RS15260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFH35_RS15265	COG0081	regulation of translation
GFH35_RS15270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFH35_RS15275	COG0222	ribosome binding
GFH35_RS15280	COG0085	RNA polymerase activity
GFH35_RS15285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFH35_RS15295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFH35_RS15300	COG0049	tRNA binding
GFH35_RS15305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFH35_RS15310	COG0051	transcription antitermination factor activity, RNA binding
GFH35_RS15315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFH35_RS15320	COG0088	Forms part of the polypeptide exit tunnel
GFH35_RS15325	COG0089	rRNA binding
GFH35_RS15330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFH35_RS15335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFH35_RS15340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFH35_RS15345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFH35_RS15350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFH35_RS15355	COG0255	Belongs to the universal ribosomal protein uL29 family
GFH35_RS15360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFH35_RS15365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFH35_RS15370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFH35_RS15375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFH35_RS15380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFH35_RS15385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFH35_RS15390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFH35_RS15395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GFH35_RS15400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFH35_RS15405	COG1841	ribosomal large subunit assembly
GFH35_RS15410	COG0200	Binds to the 23S rRNA
GFH35_RS15425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFH35_RS15430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFH35_RS15435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFH35_RS15440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFH35_RS15445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFH35_RS15450	COG0202	RNA polymerase activity
GFH35_RS15455	COG0203	ribosomal protein L17
GFH35_RS15470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFH35_RS15480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GFH35_RS15490	COG1228	amidohydrolase
GFH35_RS15500	COG2986	histidine ammonia-lyase
GFH35_RS15505	COG1309	transcriptional regulator
GFH35_RS15540	COG1696	Membrane protein involved in D-alanine export
GFH35_RS15545	COG0667	Aldo Keto reductase
GFH35_RS15620	COG1131	(ABC) transporter
GFH35_RS15640	COG3345	alpha-galactosidase
GFH35_RS15665	COG0531	amino acid
GFH35_RS15675	COG2066	Belongs to the glutaminase family
GFH35_RS15680	COG0076	glutamate decarboxylase activity
GFH35_RS15700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFH35_RS15710	COG1185	polyribonucleotide nucleotidyltransferase activity
GFH35_RS15735	COG3426	butyrate kinase activity
GFH35_RS15740	COG0280	phosphate acetyltransferase
GFH35_RS15745	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFH35_RS15750	COG2234	aminopeptidase activity
GFH35_RS15755	COG2166	iron-sulfur cluster assembly
GFH35_RS15760	COG1266	CAAX protease self-immunity
GFH35_RS15765	COG0196	riboflavin kinase activity
GFH35_RS15770	COG1011	Hydrolase
GFH35_RS15775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFH35_RS15785	COG1773	rubredoxin
GFH35_RS15790	COG1283	sodium-dependent phosphate transmembrane transporter activity
GFH35_RS15805	COG3458	cephalosporin-C deacetylase activity
GFH35_RS15810	COG0006	proline dipeptidase activity
GFH35_RS15825	COG0509	glycine decarboxylation via glycine cleavage system
GFH35_RS15830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFH35_RS15835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GFH35_RS15845	COG2217	Heavy metal translocating P-type atpase
GFH35_RS15855	COG0039	L-malate dehydrogenase activity
GFH35_RS15860	COG2996	Protein conserved in bacteria
GFH35_RS15875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH35_RS15885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFH35_RS15885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFH35_RS15900	COG1136	(ABC) transporter
GFH35_RS15900	COG0577	efflux transmembrane transporter activity
GFH35_RS15905	COG0577	efflux transmembrane transporter activity
GFH35_RS15905	COG1136	(ABC) transporter
GFH35_RS15910	COG1136	(ABC) transporter
GFH35_RS15910	COG0577	efflux transmembrane transporter activity
GFH35_RS15920	COG0335	large ribosomal subunit rRNA binding
GFH35_RS15925	COG0737	Belongs to the 5'-nucleotidase family
GFH35_RS15930	COG0737	Belongs to the 5'-nucleotidase family
GFH35_RS15935	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH35_RS15955	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFH35_RS15960	COG2204	response regulator
GFH35_RS15965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFH35_RS16075	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS16090	COG3973	AAA domain
GFH35_RS16105	COG0724	RNA recognition motif
GFH35_RS16110	COG2070	2-Nitropropane dioxygenase
GFH35_RS16115	COG0513	Belongs to the DEAD box helicase family
GFH35_RS16145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GFH35_RS16150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GFH35_RS16155	COG1663	tetraacyldisaccharide 4'-kinase activity
GFH35_RS16160	COG0616	signal peptide processing
GFH35_RS16185	COG4771	TonB-dependent receptor
GFH35_RS16190	COG0702	epimerase
GFH35_RS16225	COG0471	metal ion transport
GFH35_RS16240	COG4771	TonB-dependent receptor
GFH35_RS16270	COG4948	Mandelate Racemase Muconate Lactonizing
GFH35_RS16325	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GFH35_RS16330	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GFH35_RS16335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GFH35_RS16345	COG2205	protein histidine kinase activity
GFH35_RS16350	COG5002	protein histidine kinase activity
GFH35_RS16365	COG1131	(ABC) transporter
GFH35_RS16405	COG4771	TonB-dependent receptor
GFH35_RS16420	COG0519	Catalyzes the synthesis of GMP from XMP
GFH35_RS16440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFH35_RS16455	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GFH35_RS16460	COG0826	peptidase U32
GFH35_RS16475	COG4771	TonB-dependent receptor
GFH35_RS16485	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GFH35_RS16490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GFH35_RS16500	COG0252	asparaginase activity
GFH35_RS16505	COG0460	homoserine dehydrogenase
GFH35_RS16505	COG0527	aspartate kinase activity
GFH35_RS16510	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GFH35_RS16535	COG0668	transmembrane transport
GFH35_RS16550	COG1522	sequence-specific DNA binding
GFH35_RS16570	COG0534	Mate efflux family protein
GFH35_RS16585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH35_RS16590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH35_RS16600	COG2207	Transcriptional regulator
GFH35_RS16625	COG0475	glutathione-regulated potassium exporter activity
GFH35_RS16625	COG0589	response to stress
GFH35_RS16640	COG2076	Multidrug Resistance protein
GFH35_RS16700	COG4771	TonB-dependent receptor
GFH35_RS16710	COG1396	sequence-specific DNA binding
GFH35_RS16715	COG4413	Urea transporter
GFH35_RS16720	COG0010	Belongs to the arginase family
GFH35_RS16725	COG0058	SHG alpha-glucan phosphorylase activity
GFH35_RS16730	COG0205	6-phosphofructokinase activity
GFH35_RS16735	COG1595	DNA-templated transcription, initiation
GFH35_RS16750	COG0588	phosphoglycerate mutase activity
GFH35_RS16755	COG1830	Aldolase
GFH35_RS16785	COG0628	permease
GFH35_RS16790	COG1435	thymidine kinase activity
GFH35_RS16800	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFH35_RS16815	COG2095	MarC family integral membrane protein
GFH35_RS16825	COG1629	transport
GFH35_RS16825	COG4206	TonB-dependent receptor
GFH35_RS16830	COG4974	Belongs to the 'phage' integrase family
GFH35_RS16835	COG1629	transport
GFH35_RS16835	COG4206	TonB-dependent receptor
GFH35_RS16845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFH35_RS16855	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GFH35_RS16855	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GFH35_RS16870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFH35_RS16880	COG1162	GTPase activity
GFH35_RS16885	COG0233	cytoplasmic translational termination
GFH35_RS16895	COG2205	protein histidine kinase activity
GFH35_RS16895	COG3292	Two component regulator propeller
GFH35_RS16895	COG0745	RESPONSE REGULATOR receiver
GFH35_RS16900	COG4206	TonB-dependent receptor
GFH35_RS16900	COG1629	transport
GFH35_RS16905	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH35_RS16915	COG3250	beta-galactosidase activity
GFH35_RS16930	COG0528	UMP kinase activity
GFH35_RS16935	COG0534	Mate efflux family protein
GFH35_RS16960	COG0792	nuclease activity
GFH35_RS16980	COG1183	phosphatidylcholine synthase activity
GFH35_RS16985	COG0688	phosphatidylethanolamine metabolic process
GFH35_RS16995	COG3118	belongs to the thioredoxin family
GFH35_RS17030	COG0714	Associated with various cellular activities
GFH35_RS17045	COG0802	atpase or kinase
GFH35_RS17050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFH35_RS17060	COG2234	aminopeptidase activity
GFH35_RS17075	COG4206	TonB-dependent receptor
GFH35_RS17075	COG1629	transport
GFH35_RS17090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GFH35_RS17095	COG1373	ATPase (AAA superfamily
GFH35_RS17140	COG2431	L-lysine efflux transmembrane transporter activity
GFH35_RS17175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFH35_RS17180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFH35_RS17205	COG0360	Binds together with S18 to 16S ribosomal RNA
GFH35_RS17210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GFH35_RS17215	COG0359	binds to the 23S rRNA
GFH35_RS17255	COG1022	Amp-dependent synthetase and ligase
GFH35_RS17260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH35_RS17270	COG1216	Glycosyl transferase, family 2
GFH35_RS17290	COG1640	4-alpha-glucanotransferase
GFH35_RS17300	COG0778	Nitroreductase
GFH35_RS17305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFH35_RS17315	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS17345	COG2315	Protein conserved in bacteria
GFH35_RS17375	COG3876	Protein conserved in bacteria
GFH35_RS17390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFH35_RS17395	COG2502	aspartate--ammonia ligase
GFH35_RS17415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH35_RS17430	COG0166	Belongs to the GPI family
GFH35_RS17435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFH35_RS17440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFH35_RS17445	COG0534	Mate efflux family protein
GFH35_RS17450	COG2207	Transcriptional regulator
GFH35_RS17450	COG1609	Transcriptional regulator
GFH35_RS17515	COG2188	Transcriptional regulator
GFH35_RS17525	COG1940	carbohydrate kinase activity
GFH35_RS17530	COG4206	TonB-dependent receptor
GFH35_RS17530	COG1629	transport
GFH35_RS17535	COG0702	epimerase
GFH35_RS17580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH35_RS17620	COG2985	domain, Protein
GFH35_RS17620	COG0569	domain protein
GFH35_RS17625	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH35_RS17630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH35_RS17630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH35_RS17635	COG1595	DNA-templated transcription, initiation
GFH35_RS17700	COG4206	TonB-dependent receptor
GFH35_RS17700	COG1629	transport
GFH35_RS17765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFH35_RS17785	COG3681	Belongs to the UPF0597 family
GFH35_RS17800	COG0129	dihydroxy-acid dehydratase activity
GFH35_RS17805	COG0028	Belongs to the TPP enzyme family
GFH35_RS17820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFH35_RS17830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GFH35_RS17835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFH35_RS17845	COG0372	Belongs to the citrate synthase family
GFH35_RS17900	COG4372	Transposase
GFH35_RS17905	COG0205	6-phosphofructokinase activity
GFH35_RS17910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GFH35_RS17915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GFH35_RS17935	COG0084	hydrolase, TatD family'
GFH35_RS17945	COG0811	peptide transport
GFH35_RS17975	COG1522	sequence-specific DNA binding
GFH35_RS17985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GFH35_RS18005	COG1595	DNA-templated transcription, initiation
GFH35_RS18055	COG0488	(ABC) transporter
GFH35_RS18060	COG2204	response regulator
GFH35_RS18070	COG1629	transport
GFH35_RS18075	COG4206	TonB-dependent receptor
GFH35_RS18075	COG1629	transport
GFH35_RS18080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GFH35_RS18085	COG1272	protein, Hemolysin III
GFH35_RS18090	COG0673	inositol 2-dehydrogenase activity
GFH35_RS18095	COG0632	four-way junction helicase activity
GFH35_RS18110	COG0617	tRNA 3'-terminal CCA addition
GFH35_RS18120	COG3119	arylsulfatase activity
GFH35_RS18135	COG1505	serine-type exopeptidase activity
GFH35_RS18175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFH35_RS18200	COG4771	TonB-dependent receptor
GFH35_RS18205	COG0561	phosphatase activity
GFH35_RS18220	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH35_RS18265	COG1538	Outer membrane efflux protein
GFH35_RS18295	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS18320	COG1629	transport
GFH35_RS18320	COG4206	TonB-dependent receptor
GFH35_RS18325	COG4206	TonB-dependent receptor
GFH35_RS18325	COG1629	transport
GFH35_RS18380	COG1328	CTP reductase activity
GFH35_RS18390	COG2814	Major facilitator Superfamily
GFH35_RS18400	COG0750	zinc metalloprotease
GFH35_RS18405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GFH35_RS18415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFH35_RS18420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFH35_RS18440	COG0194	GDP metabolic process
GFH35_RS18450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFH35_RS18460	COG1408	metallophosphoesterase
GFH35_RS18465	COG1575	Belongs to the MenA family. Type 1 subfamily
GFH35_RS18470	COG1088	dTDP-glucose 4,6-dehydratase activity
GFH35_RS18475	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFH35_RS18485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFH35_RS18545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH35_RS18550	COG1120	ATPase activity
GFH35_RS18575	COG1192	Involved in chromosome partitioning
GFH35_RS18585	COG1629	transport
GFH35_RS18650	COG4974	Belongs to the 'phage' integrase family
GFH35_RS18685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFH35_RS18690	COG2873	o-acetylhomoserine
GFH35_RS18700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH35_RS18710	COG0439	Biotin carboxylase
GFH35_RS18715	COG3118	belongs to the thioredoxin family
GFH35_RS18720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GFH35_RS18740	COG1028	Short-chain dehydrogenase reductase Sdr
GFH35_RS18765	COG4977	sequence-specific DNA binding
GFH35_RS18765	COG1917	Cupin 2, conserved barrel domain protein
GFH35_RS18830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFH35_RS18835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFH35_RS18840	COG0066	3-isopropylmalate dehydratase activity
GFH35_RS18850	COG0473	3-isopropylmalate dehydrogenase activity
GFH35_RS18855	COG0671	phosphoesterase, PA-phosphatase related
GFH35_RS18860	COG1368	sulfuric ester hydrolase activity
GFH35_RS18865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFH35_RS18875	COG0514	ATP-dependent DNA helicase (RecQ)
GFH35_RS18900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFH35_RS18915	COG0124	histidyl-tRNA synthetase
GFH35_RS18920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GFH35_RS18930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GFH35_RS18960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFH35_RS18965	COG0459	protein refolding
GFH35_RS18995	COG0028	Belongs to the TPP enzyme family
GFH35_RS19020	COG0484	heat shock protein binding
GFH35_RS19030	COG1956	GAF domain-containing protein
GFH35_RS19045	COG0705	Rhomboid family
GFH35_RS19050	COG1960	acyl-CoA dehydrogenase activity
GFH35_RS19055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFH35_RS19085	COG5002	protein histidine kinase activity
GFH35_RS19090	COG2205	protein histidine kinase activity
GFH35_RS19090	COG2202	Pas domain
GFH35_RS19095	COG2205	protein histidine kinase activity
GFH35_RS19095	COG2202	Pas domain
GFH35_RS19135	COG0475	glutathione-regulated potassium exporter activity
GFH35_RS19140	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFH35_RS19150	COG1621	beta-fructofuranosidase activity
GFH35_RS19160	COG1629	transport
GFH35_RS19180	COG1621	beta-fructofuranosidase activity
GFH35_RS19190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GFH35_RS19190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GFH35_RS19200	COG0745	RESPONSE REGULATOR receiver
GFH35_RS19200	COG2205	protein histidine kinase activity
GFH35_RS19200	COG3292	Two component regulator propeller
GFH35_RS19210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFH35_RS19220	COG4176	ABC-type proline glycine betaine transport system permease component
GFH35_RS19225	COG2113	Glycine betaine
GFH35_RS19255	COG4372	Transposase
GFH35_RS19270	COG1649	PFAM Uncharacterised BCR, COG1649
GFH35_RS19275	COG1966	Carbon starvation protein
GFH35_RS19295	COG1649	PFAM Uncharacterised BCR, COG1649
GFH35_RS19310	COG3292	Two component regulator propeller
GFH35_RS19310	COG2205	protein histidine kinase activity
GFH35_RS19310	COG0745	RESPONSE REGULATOR receiver
GFH35_RS19310	COG0745	RESPONSE REGULATOR receiver
GFH35_RS19310	COG3292	Two component regulator propeller
GFH35_RS19310	COG2205	protein histidine kinase activity
GFH35_RS19320	COG1280	lysine exporter protein (LysE YggA)
GFH35_RS19335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GFH35_RS19355	COG0511	ligase activity, forming carbon-carbon bonds
GFH35_RS19360	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GFH35_RS19385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH35_RS19400	COG1373	ATPase (AAA superfamily
GFH35_RS19405	COG0254	rRNA binding
GFH35_RS19410	COG0191	fructose-bisphosphate aldolase activity
GFH35_RS19420	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GFH35_RS19425	COG0511	ligase activity, forming carbon-carbon bonds
GFH35_RS19435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH35_RS19450	COG1629	transport
GFH35_RS19460	COG0288	reversible hydration of carbon dioxide
GFH35_RS19470	COG0778	Nitroreductase
GFH35_RS19490	COG0424	maF-like protein
GFH35_RS19500	COG2311	Membrane
GFH35_RS19515	COG0126	phosphoglycerate kinase activity
GFH35_RS19520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFH35_RS19525	COG2814	Major facilitator Superfamily
GFH35_RS19530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFH35_RS19540	COG4372	Transposase
GFH35_RS19575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GFH35_RS19580	COG1523	belongs to the glycosyl hydrolase 13 family
GFH35_RS19590	COG2211	Major facilitator Superfamily
GFH35_RS19605	COG3661	Belongs to the glycosyl hydrolase 67 family
GFH35_RS19610	COG1119	ATPase activity
GFH35_RS19640	COG1629	transport
GFH35_RS19640	COG4206	TonB-dependent receptor
GFH35_RS19655	COG0588	phosphoglycerate mutase activity
GFH35_RS19660	COG1830	Aldolase
GFH35_RS19665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFH35_RS19670	COG3292	Two component regulator propeller
GFH35_RS19670	COG0745	RESPONSE REGULATOR receiver
GFH35_RS19670	COG3292	Two component regulator propeller
GFH35_RS19670	COG0745	RESPONSE REGULATOR receiver
GFH35_RS19670	COG2205	protein histidine kinase activity
GFH35_RS19670	COG2205	protein histidine kinase activity
GFH35_RS19680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFH35_RS19700	COG4771	TonB-dependent receptor
GFH35_RS19710	COG3119	arylsulfatase activity
GFH35_RS19715	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH35_RS19720	COG3250	beta-galactosidase activity
GFH35_RS19730	COG0668	transmembrane transport
GFH35_RS19745	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFH35_RS19770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFH35_RS19775	COG1983	PspC domain protein
GFH35_RS19795	COG4372	Transposase
GFH35_RS19830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFH35_RS19835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFH35_RS19840	COG0534	Mate efflux family protein
GFH35_RS19845	COG3119	arylsulfatase activity
GFH35_RS19860	COG0037	tRNA processing
GFH35_RS19865	COG1918	ferrous iron import across plasma membrane
GFH35_RS19865	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GFH35_RS19915	COG0346	lactoylglutathione lyase activity
GFH35_RS19930	COG0259	pyridoxamine-phosphate oxidase activity
GFH35_RS19935	COG1741	Belongs to the pirin family
GFH35_RS19940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFH35_RS19955	COG1595	DNA-templated transcription, initiation
GFH35_RS19970	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GFH35_RS19975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GFH35_RS19985	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GFH35_RS20035	COG0686	Belongs to the AlaDH PNT family
GFH35_RS20050	COG4206	TonB-dependent receptor
GFH35_RS20050	COG1629	transport
GFH35_RS20070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH35_RS20100	COG0488	(ABC) transporter
GFH35_RS20105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH35_RS20110	COG3059	membrane
GFH35_RS20120	COG0295	cytidine deaminase activity
GFH35_RS20125	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFH35_RS20130	COG1252	NADH dehydrogenase
GFH35_RS20140	COG1136	(ABC) transporter
GFH35_RS20160	COG0577	efflux transmembrane transporter activity
GFH35_RS20190	COG2204	response regulator
GFH35_RS20195	COG4191	Histidine kinase
GFH35_RS20210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GFH35_RS20220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFH35_RS20235	COG1979	alcohol dehydrogenase
GFH35_RS20240	COG4771	TonB-dependent receptor
GFH35_RS20275	COG3023	N-Acetylmuramoyl-L-alanine amidase
GFH35_RS20325	COG1530	ribonuclease E activity
GFH35_RS20335	COG1194	a g-specific adenine glycosylase
GFH35_RS20340	COG0629	single-stranded DNA binding
GFH35_RS20365	COG3033	Beta-eliminating lyase
GFH35_RS20380	COG4206	TonB-dependent receptor
GFH35_RS20440	COG0745	RESPONSE REGULATOR receiver
GFH35_RS20455	COG0488	(ABC) transporter
GFH35_RS20470	COG0436	Aminotransferase
GFH35_RS20475	COG1136	(ABC) transporter
GFH35_RS20475	COG0577	efflux transmembrane transporter activity
GFH35_RS20480	COG0189	ligase activity
GFH35_RS20480	COG0569	domain protein
GFH35_RS20485	COG0456	acetyltransferase
GFH35_RS20490	COG1215	transferase activity, transferring glycosyl groups
GFH35_RS20495	COG0628	permease
GFH35_RS20515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH35_RS20530	COG4771	TonB-dependent receptor
GFH35_RS20535	COG0702	epimerase
GFH35_RS20550	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH35_RS20575	COG3279	Response regulator of the LytR AlgR family
GFH35_RS20585	COG1690	Belongs to the RtcB family
GFH35_RS20605	COG1620	l-lactate permease
GFH35_RS20615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH35_RS20620	COG0439	Biotin carboxylase
GFH35_RS20625	COG0511	ligase activity, forming carbon-carbon bonds
GFH35_RS20630	COG2205	protein histidine kinase activity
GFH35_RS20630	COG0784	Response regulator, receiver
GFH35_RS20660	COG2226	methyltransferase
GFH35_RS20675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFH35_RS20675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GFH35_RS20685	COG4771	TonB-dependent receptor
GFH35_RS20695	COG2223	nitrite transmembrane transporter activity
GFH35_RS20710	COG1609	Transcriptional regulator
GFH35_RS20715	COG1028	Short-chain dehydrogenase reductase Sdr
GFH35_RS20720	COG1312	Catalyzes the dehydration of D-mannonate
GFH35_RS20730	COG5002	protein histidine kinase activity
GFH35_RS20735	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GFH35_RS20770	COG1162	GTPase activity
GFH35_RS20785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GFH35_RS20800	COG3831	ATPase activity
GFH35_RS20800	COG4884	unkown
GFH35_RS20860	COG4771	TonB-dependent receptor
GFH35_RS20875	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GFH35_RS20885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFH35_RS20910	COG1506	peptidase
GFH35_RS20910	COG0823	Involved in the tonB-independent uptake of proteins
GFH35_RS20910	COG4946	Tricorn protease homolog
GFH35_RS20930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFH35_RS20945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GFH35_RS20980	COG2885	chlorophyll binding
GFH35_RS20980	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GFH35_RS20985	COG3831	ATPase activity
GFH35_RS20985	COG4884	unkown
GFH35_RS21000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFH35_RS21010	COG0534	Mate efflux family protein
GFH35_RS21030	COG0693	protein deglycase activity
GFH35_RS21045	COG0788	formyltetrahydrofolate deformylase activity
GFH35_RS21050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFH35_RS21055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFH35_RS21060	COG0107	imidazoleglycerol-phosphate synthase activity
GFH35_RS21065	COG0140	phosphoribosyl-ATP diphosphatase activity
GFH35_RS21065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFH35_RS21070	COG2884	Cell division ATP-binding protein ftsE
GFH35_RS21075	COG0527	aspartate kinase activity
GFH35_RS21080	COG0019	diaminopimelate decarboxylase activity
GFH35_RS21100	COG0156	8-amino-7-oxononanoate synthase activity
GFH35_RS21105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH35_RS21115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFH35_RS21120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFH35_RS21120	COG0321	lipoyl(octanoyl) transferase activity
GFH35_RS21140	COG0592	DNA-directed DNA polymerase activity
GFH35_RS21155	COG0497	DNA recombination
GFH35_RS21160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFH35_RS21195	COG1028	Short-chain dehydrogenase reductase Sdr
GFH35_RS21205	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GFH35_RS21220	COG1216	Glycosyl transferase, family 2
GFH35_RS21320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GFH35_RS21385	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GFH35_RS21395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFH35_RS21410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GFH35_RS21420	COG0586	Pfam SNARE associated Golgi protein
GFH35_RS21430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFH35_RS21440	COG0573	inorganic phosphate transmembrane transporter activity
GFH35_RS21445	COG0581	inorganic phosphate transmembrane transporter activity
GFH35_RS21450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFH35_RS21455	COG0704	Plays a role in the regulation of phosphate uptake
GFH35_RS21465	COG0778	Nitroreductase
GFH35_RS21470	COG1295	ribonuclease BN
GFH35_RS21485	COG4948	Mandelate Racemase Muconate Lactonizing
GFH35_RS21490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH35_RS21495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFH35_RS21550	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GFH35_RS21570	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFH35_RS21580	COG0058	SHG alpha-glucan phosphorylase activity
GFH35_RS21585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH35_RS21590	COG3842	ATPase activity
GFH35_RS21595	COG1176	ABC-type spermidine putrescine transport system, permease component I
GFH35_RS21600	COG1177	transmembrane transport
GFH35_RS21620	COG2204	response regulator
GFH35_RS21640	COG0738	Major facilitator superfamily
GFH35_RS21650	COG1070	Carbohydrate kinase
GFH35_RS21660	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
GFH35_RS21670	COG0228	four-way junction DNA binding
GFH35_RS21690	COG1733	regulation of RNA biosynthetic process
GFH35_RS21775	COG4452	Inner membrane protein CreD
GFH35_RS21790	COG2721	sulfolactate sulfo-lyase activity
GFH35_RS21795	COG1609	Transcriptional regulator
GFH35_RS21810	COG1230	cation diffusion facilitator family transporter
GFH35_RS21815	COG2985	domain, Protein
GFH35_RS21815	COG0490	domain, Protein
GFH35_RS21825	COG4771	TonB-dependent receptor
GFH35_RS21835	COG4771	TonB-dependent receptor
GFH35_RS21870	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GFH35_RS21875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFH35_RS21875	COG1333	cytochrome c biogenesis protein
GFH35_RS21900	COG3487	Iron-regulated protein
GFH35_RS21905	COG1730	sister chromatid segregation
GFH35_RS21920	COG0138	bifunctional purine biosynthesis protein purh
GFH35_RS21955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFH35_RS21960	COG0745	RESPONSE REGULATOR receiver
GFH35_RS21970	COG0252	asparaginase activity
GFH35_RS21975	COG0159	tryptophan synthase activity
GFH35_RS21980	COG0135	phosphoribosylanthranilate isomerase activity
GFH35_RS21985	COG0134	indole-3-glycerol-phosphate synthase activity
GFH35_RS21990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFH35_RS22000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFH35_RS22005	COG0133	tryptophan synthase activity
GFH35_RS22015	COG1979	alcohol dehydrogenase
GFH35_RS22020	COG2205	protein histidine kinase activity
GFH35_RS22020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH35_RS22025	COG0471	metal ion transport
GFH35_RS22025	COG0490	domain, Protein
GFH35_RS22055	COG0004	ammonium transporteR
GFH35_RS22060	COG0347	Belongs to the P(II) protein family
GFH35_RS22070	COG0436	Aminotransferase
GFH35_RS22075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFH35_RS22090	COG0367	asparagine synthase
GFH35_RS22100	COG0067	glutamate synthase
GFH35_RS22100	COG0070	glutamate synthase
GFH35_RS22100	COG0069	glutamate synthase activity
GFH35_RS22105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFH35_RS22115	COG0505	Belongs to the CarA family
GFH35_RS22120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GFH35_RS22130	COG2207	Transcriptional regulator
GFH35_RS22130	COG1917	Cupin 2, conserved barrel domain protein
GFH35_RS22145	COG1131	(ABC) transporter
GFH35_RS22150	COG0842	Transport permease protein
GFH35_RS22155	COG0842	Transport permease protein
GFH35_RS22165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFH35_RS22185	COG0556	nucleotide-excision repair
GFH35_RS22190	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GFH35_RS22225	COG1388	LysM domain
GFH35_RS22225	COG3942	CHAP domain
GFH35_RS22235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFH35_RS22255	COG1983	PspC domain protein
GFH35_RS22270	COG0823	Involved in the tonB-independent uptake of proteins
GFH35_RS22270	COG1506	peptidase
GFH35_RS22275	COG0534	Mate efflux family protein
GFH35_RS22280	COG0706	membrane insertase activity
GFH35_RS22285	COG0504	CTP synthase activity
GFH35_RS22315	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFH35_RS22375	COG0438	transferase activity, transferring glycosyl groups
GFH35_RS22415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFH35_RS22420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GFH35_RS22475	COG4656	Part of a membrane complex involved in electron transport
GFH35_RS22480	COG4658	electron transport chain
GFH35_RS22485	COG4659	FMN binding
GFH35_RS22490	COG4660	Part of a membrane complex involved in electron transport
GFH35_RS22495	COG4657	Part of a membrane complex involved in electron transport
GFH35_RS22500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFH35_RS22505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GFH35_RS22510	COG0305	Participates in initiation and elongation during chromosome replication
GFH35_RS22515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH35_RS22515	COG0072	phenylalanine-tRNA ligase activity
GFH35_RS22520	COG0217	transcriptional regulatory protein
GFH35_RS22535	COG0708	Exodeoxyribonuclease III
GFH35_RS22560	COG0481	GTPase activity
GFH35_RS22570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFH35_RS22580	COG0024	Methionine aminopeptidase
GFH35_RS22600	COG0564	pseudouridine synthase activity
GFH35_RS22605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFH35_RS22610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFH35_RS22610	COG0574	Belongs to the PEP-utilizing enzyme family
GFH35_RS22630	COG1192	Involved in chromosome partitioning
GFH35_RS22730	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFH35_RS22730	COG1388	LysM domain
GFH35_RS22740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFH35_RS22815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH35_RS22820	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GFH35_RS22820	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GFH35_RS22895	COG4474	Belongs to the UPF0398 family
GFH35_RS22915	COG0358	DNA primase activity
GFH35_RS22915	COG0305	Participates in initiation and elongation during chromosome replication
GFH35_RS22975	COG1192	Involved in chromosome partitioning
GFH35_RS23010	COG3344	reverse transcriptase
GFH35_RS23095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFH35_RS23160	COG1192	Involved in chromosome partitioning
GFH35_RS23185	COG0758	DNA mediated transformation
GFH35_RS23205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH35_RS23290	COG1396	sequence-specific DNA binding
GFH35_RS23300	COG0776	regulation of translation
GFH35_RS23350	COG0352	thiamine-phosphate diphosphorylase activity
GFH35_RS23355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFH35_RS23365	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GFH35_RS23370	COG2022	thiamine diphosphate biosynthetic process
GFH35_RS23375	COG0352	thiamine-phosphate diphosphorylase activity
GFH35_RS23385	COG5002	protein histidine kinase activity
GFH35_RS23460	COG3118	belongs to the thioredoxin family
GFH35_RS23480	COG5002	protein histidine kinase activity
GFH35_RS23485	COG0745	RESPONSE REGULATOR receiver
GFH35_RS23490	COG1022	Amp-dependent synthetase and ligase
GFH35_RS23500	COG2233	PERMEase
GFH35_RS23505	COG1151	hydroxylamine reductase activity
GFH35_RS23520	COG2204	response regulator
GFH35_RS23535	COG1136	(ABC) transporter
GFH35_RS23535	COG0577	efflux transmembrane transporter activity
GFH35_RS23545	COG0534	Mate efflux family protein
GFH35_RS23550	COG1011	Hydrolase
GFH35_RS23555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFH35_RS23565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFH35_RS23595	COG0454	-acetyltransferase
GFH35_RS23600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GFH35_RS23605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFH35_RS23610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFH35_RS23620	COG0356	it plays a direct role in the translocation of protons across the membrane
GFH35_RS23625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFH35_RS23630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFH35_RS23635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFH35_RS23640	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFH35_RS23645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFH35_RS23655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH35_RS23660	COG2431	L-lysine efflux transmembrane transporter activity
GFH35_RS23670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFH35_RS23670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH35_RS23675	COG1690	Belongs to the RtcB family
GFH35_RS23685	COG2207	Transcriptional regulator
GFH35_RS23690	COG2207	Transcriptional regulator
GFH35_RS23690	COG1917	Cupin 2, conserved barrel domain protein
GFH35_RS23710	COG2985	domain, Protein
GFH35_RS23715	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GFH35_RS23720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFH35_RS23735	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GFH35_RS23740	COG0540	Belongs to the ATCase OTCase family
GFH35_RS23770	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFH35_RS23825	COG0438	transferase activity, transferring glycosyl groups
GFH35_RS23830	COG0110	maltose O-acetyltransferase activity
GFH35_RS23855	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GFH35_RS23890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GFH35_RS23900	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GFH35_RS23920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFH35_RS23925	COG2205	protein histidine kinase activity
GFH35_RS23955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFH35_RS23965	COG2731	YhcH YjgK YiaL family protein
GFH35_RS23970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GFH35_RS23990	COG0348	domain, Protein
GFH35_RS23995	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
GFH35_RS24125	COG3344	reverse transcriptase
GFH35_RS24165	COG0622	Phosphoesterase
GFH35_RS24180	COG2801	Transposase and inactivated derivatives
GFH35_RS24190	COG4771	TonB-dependent receptor
GFH35_RS24210	COG1132	(ABC) transporter
GFH35_RS24215	COG2375	cellular response to nickel ion
GFH35_RS24215	COG1132	(ABC) transporter
GFH35_RS24225	COG0428	transporter
GFH35_RS24275	COG3015	lipoprotein NlpE involved in copper resistance
GFH35_RS24405	COG0745	RESPONSE REGULATOR receiver
GFH35_RS24405	COG2205	protein histidine kinase activity
GFH35_RS24405	COG2205	protein histidine kinase activity
GFH35_RS24405	COG3292	Two component regulator propeller
GFH35_RS24405	COG0745	RESPONSE REGULATOR receiver
GFH35_RS24405	COG3292	Two component regulator propeller
GFH35_RS24450	COG0702	epimerase
GFH35_RS24455	COG1629	transport
GFH35_RS24460	COG2205	protein histidine kinase activity
GFH35_RS24460	COG3292	Two component regulator propeller
GFH35_RS24460	COG0745	RESPONSE REGULATOR receiver
GFH35_RS24495	COG2095	MarC family integral membrane protein
GFH35_RS24505	COG1830	Aldolase
GFH35_RS24510	COG0588	phosphoglycerate mutase activity
GFH35_RS24525	COG0205	6-phosphofructokinase activity
GFH35_RS24530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFH35_RS24530	COG4651	solute:proton antiporter activity
GFH35_RS24540	COG0010	Belongs to the arginase family
GFH35_RS24550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH35_RS24550	COG2198	Histidine kinase
GFH35_RS24550	COG2205	protein histidine kinase activity
GFH35_RS24550	COG0784	Response regulator, receiver
GFH35_RS24615	COG0739	heme binding
GFH35_RS24690	COG4974	Belongs to the 'phage' integrase family
GFH35_RS24715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GFH35_RS24720	COG0045	succinate-CoA ligase (ADP-forming) activity
GFH35_RS24730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFH35_RS24735	COG0351	phosphomethylpyrimidine kinase
GFH35_RS24750	COG2115	Belongs to the xylose isomerase family
GFH35_RS24755	COG2814	Major facilitator Superfamily
GFH35_RS24755	COG0477	Major facilitator Superfamily
GFH35_RS24790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH35_RS24790	COG3153	acetyltransferase
GFH35_RS24800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFH35_RS24810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFH35_RS24825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFH35_RS24865	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFH35_RS24885	COG1904	glucuronate isomerase
GFH35_RS24890	COG1609	Transcriptional regulator
GFH35_RS24895	COG0246	Mannitol dehydrogenase
GFH35_RS24925	COG0513	Belongs to the DEAD box helicase family
GFH35_RS24930	COG0560	Phosphoserine phosphatase
GFH35_RS24930	COG3830	Belongs to the UPF0237 family
GFH35_RS24950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFH35_RS24955	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GFH35_RS24960	COG2433	Pfam Transposase IS66
GFH35_RS25095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFH35_RS25110	COG0156	8-amino-7-oxononanoate synthase activity
GFH35_RS25115	COG1597	lipid kinase activity
GFH35_RS25120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFH35_RS25180	COG4988	ABC transporter
GFH35_RS25200	COG1595	DNA-templated transcription, initiation
GFH35_RS25205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFH35_RS25215	COG1538	Outer membrane efflux protein
GFH35_RS25220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFH35_RS25235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GFH35_RS25250	COG0543	2 iron, 2 sulfur cluster binding
GFH35_RS25255	COG0167	dihydroorotate dehydrogenase activity
GFH35_RS25265	COG0336	Belongs to the RNA methyltransferase TrmD family
GFH35_RS25270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFH35_RS25275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH35_RS25305	COG1752	Esterase of the alpha-beta hydrolase superfamily
GFH35_RS25310	COG0326	Molecular chaperone. Has ATPase activity
GFH35_RS25315	COG0542	response to heat
GFH35_RS25320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFH35_RS25360	COG2304	oxidoreductase activity
GFH35_RS25375	COG0714	Associated with various cellular activities
GFH35_RS25385	COG0776	regulation of translation
GFH35_RS25390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH35_RS25395	COG0552	protein localization to endoplasmic reticulum
GFH35_RS25405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFH35_RS25410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFH35_RS25420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFH35_RS25455	COG2205	protein histidine kinase activity
GFH35_RS25460	COG0745	RESPONSE REGULATOR receiver
GFH35_RS25465	COG0442	prolyl-tRNA aminoacylation
GFH35_RS25500	COG3292	Two component regulator propeller
GFH35_RS25500	COG0745	RESPONSE REGULATOR receiver
GFH35_RS25500	COG2205	protein histidine kinase activity
GFH35_RS25500	COG0745	RESPONSE REGULATOR receiver
GFH35_RS25500	COG2205	protein histidine kinase activity
GFH35_RS25500	COG3292	Two component regulator propeller
GFH35_RS25560	COG4372	Transposase
GFH35_RS25570	COG1011	Hydrolase
GFH35_RS25575	COG0300	oxidoreductase activity
GFH35_RS25590	COG2966	Psort location CytoplasmicMembrane, score
GFH35_RS25620	COG0745	RESPONSE REGULATOR receiver
GFH35_RS25620	COG2205	protein histidine kinase activity
GFH35_RS25620	COG3292	Two component regulator propeller
GFH35_RS25625	COG3250	beta-galactosidase activity
GFH35_RS25720	COG5002	protein histidine kinase activity
GFH35_RS25725	COG0745	RESPONSE REGULATOR receiver
GFH35_RS25730	COG3250	beta-galactosidase activity
GFH35_RS25735	COG3250	beta-galactosidase activity
GFH35_RS25740	COG0784	Response regulator, receiver
GFH35_RS25740	COG2205	protein histidine kinase activity
GFH35_RS25750	COG3250	beta-galactosidase activity
GFH35_RS25770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFH35_RS25805	COG1629	transport
GFH35_RS25805	COG4206	TonB-dependent receptor
GFH35_RS25825	COG3420	alginic acid biosynthetic process
GFH35_RS25840	COG4232	protein-disulfide reductase activity
GFH35_RS25975	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFH35_RS25985	COG3408	Glycogen debranching enzyme
GFH35_RS25990	COG1028	Short-chain dehydrogenase reductase Sdr
GFH35_RS26010	COG3408	Glycogen debranching enzyme
GFH35_RS26040	COG0702	epimerase
GFH35_RS26045	COG4206	TonB-dependent receptor
GFH35_RS26045	COG1629	transport
GFH35_RS26060	COG3537	Alpha-1,2-mannosidase
GFH35_RS26065	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GFH35_RS26095	COG4771	TonB-dependent receptor
GFH35_RS26105	COG4206	TonB-dependent receptor
GFH35_RS26105	COG1629	transport
GFH35_RS26165	COG0745	RESPONSE REGULATOR receiver
GFH35_RS26225	COG1475	DNA binding
GFH35_RS26230	COG3969	phosphoadenosine phosphosulfate
GFH35_RS26255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFH35_RS26310	COG0776	regulation of translation
GFH35_RS26360	COG0167	dihydroorotate dehydrogenase activity
GFH35_RS26365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFH35_RS26410	COG4227	nucleotidyltransferase activity
GFH35_RS26485	COG2814	Major facilitator Superfamily
GFH35_RS26490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFH35_RS26530	COG4974	Belongs to the 'phage' integrase family
GFH35_RS26585	COG0739	heme binding
GFH35_RS26585	COG1196	nuclear chromosome segregation
GFH35_RS26585	COG0741	lytic transglycosylase activity