locus-tag	class	description
C4H11_RS00010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4H11_RS00040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4H11_RS00045	COG0488	(ABC) transporter
C4H11_RS00060	COG2183	response to ionizing radiation
C4H11_RS00065	COG0366	Alpha amylase catalytic
C4H11_RS00075	COG0778	Nitroreductase
C4H11_RS00095	COG0424	maF-like protein
C4H11_RS00110	COG0126	phosphoglycerate kinase activity
C4H11_RS00115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4H11_RS00125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4H11_RS00135	COG1649	PFAM Uncharacterised BCR, COG1649
C4H11_RS00150	COG3292	Two component regulator propeller
C4H11_RS00150	COG0745	RESPONSE REGULATOR receiver
C4H11_RS00150	COG2205	protein histidine kinase activity
C4H11_RS00155	COG0047	phosphoribosylformylglycinamidine synthase activity
C4H11_RS00155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4H11_RS00160	COG1280	lysine exporter protein (LysE YggA)
C4H11_RS00175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4H11_RS00185	COG4771	TonB-dependent receptor
C4H11_RS00215	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS00240	COG2885	chlorophyll binding
C4H11_RS00290	COG2233	PERMEase
C4H11_RS00310	COG4771	TonB-dependent receptor
C4H11_RS00320	COG1629	transport
C4H11_RS00325	COG0702	epimerase
C4H11_RS00330	COG0006	proline dipeptidase activity
C4H11_RS00335	COG0632	four-way junction helicase activity
C4H11_RS00340	COG0673	inositol 2-dehydrogenase activity
C4H11_RS00385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4H11_RS00395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4H11_RS00400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4H11_RS00420	COG0194	GDP metabolic process
C4H11_RS00425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4H11_RS00430	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4H11_RS00435	COG0523	cobalamin synthesis protein
C4H11_RS00450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4H11_RS00465	COG2873	o-acetylhomoserine
C4H11_RS00475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4H11_RS00480	COG0284	orotidine-5'-phosphate decarboxylase activity
C4H11_RS00485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4H11_RS00505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4H11_RS00525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4H11_RS00530	COG2226	methyltransferase
C4H11_RS00535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4H11_RS00545	COG1702	phosphate starvation-inducible protein PhoH
C4H11_RS00560	COG1496	oxidoreductase activity
C4H11_RS00565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4H11_RS00570	COG0563	adenylate kinase activity
C4H11_RS00575	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4H11_RS00590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4H11_RS00595	COG1523	belongs to the glycosyl hydrolase 13 family
C4H11_RS00600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4H11_RS00610	COG0671	phosphoesterase, PA-phosphatase related
C4H11_RS00630	COG0745	RESPONSE REGULATOR receiver
C4H11_RS00640	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4H11_RS00655	COG3142	Participates in the control of copper homeostasis
C4H11_RS00660	COG1418	mRNA catabolic process
C4H11_RS00675	COG2832	Protein of unknown function (DUF454)
C4H11_RS00680	COG0351	phosphomethylpyrimidine kinase
C4H11_RS00700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4H11_RS00715	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C4H11_RS00720	COG0540	Belongs to the ATCase OTCase family
C4H11_RS00725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C4H11_RS00735	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4H11_RS00750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4H11_RS00760	COG0156	8-amino-7-oxononanoate synthase activity
C4H11_RS00770	COG1597	lipid kinase activity
C4H11_RS00775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4H11_RS00785	COG2957	Belongs to the agmatine deiminase family
C4H11_RS00790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4H11_RS00810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4H11_RS00910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C4H11_RS00915	COG0564	pseudouridine synthase activity
C4H11_RS00925	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C4H11_RS00940	COG1482	cell wall glycoprotein biosynthetic process
C4H11_RS00945	COG2198	Histidine kinase
C4H11_RS00945	COG0784	Response regulator, receiver
C4H11_RS00945	COG5002	protein histidine kinase activity
C4H11_RS00950	COG0463	Glycosyl transferase, family 2
C4H11_RS00965	COG2184	nucleotidyltransferase activity
C4H11_RS00980	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS01000	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C4H11_RS01005	COG1805	sodium ion transport
C4H11_RS01010	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C4H11_RS01020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C4H11_RS01035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4H11_RS01040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4H11_RS01050	COG1929	Belongs to the glycerate kinase type-1 family
C4H11_RS01055	COG1739	Uncharacterized protein family UPF0029
C4H11_RS01105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4H11_RS01110	COG0242	peptide deformylase activity
C4H11_RS01120	COG1193	negative regulation of DNA recombination
C4H11_RS01130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4H11_RS01135	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C4H11_RS01140	COG3119	arylsulfatase activity
C4H11_RS01150	COG1629	transport
C4H11_RS01150	COG4206	TonB-dependent receptor
C4H11_RS01165	COG4771	TonB-dependent receptor
C4H11_RS01170	COG0546	phosphoglycolate phosphatase activity
C4H11_RS01190	COG0612	Peptidase, M16
C4H11_RS01195	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4H11_RS01200	COG1597	lipid kinase activity
C4H11_RS01205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4H11_RS01240	COG2996	Protein conserved in bacteria
C4H11_RS01275	COG0488	(ABC) transporter
C4H11_RS01280	COG2204	response regulator
C4H11_RS01290	COG0617	tRNA 3'-terminal CCA addition
C4H11_RS01295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4H11_RS01305	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4H11_RS01310	COG1088	dTDP-glucose 4,6-dehydratase activity
C4H11_RS01315	COG1575	Belongs to the MenA family. Type 1 subfamily
C4H11_RS01335	COG1484	DNA-dependent DNA replication
C4H11_RS01340	COG4584	PFAM Integrase catalytic
C4H11_RS01345	COG1518	maintenance of DNA repeat elements
C4H11_RS01370	COG1203	CRISPR-associated helicase, Cas3
C4H11_RS01410	COG1904	glucuronate isomerase
C4H11_RS01415	COG1609	Transcriptional regulator
C4H11_RS01420	COG0246	Mannitol dehydrogenase
C4H11_RS01450	COG0513	Belongs to the DEAD box helicase family
C4H11_RS01455	COG3830	Belongs to the UPF0237 family
C4H11_RS01455	COG0560	Phosphoserine phosphatase
C4H11_RS01500	COG0343	queuine tRNA-ribosyltransferase activity
C4H11_RS01505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4H11_RS01510	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4H11_RS01515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4H11_RS01520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4H11_RS01525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4H11_RS01530	COG0131	Imidazoleglycerol-phosphate dehydratase
C4H11_RS01530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4H11_RS01535	COG4771	TonB-dependent receptor
C4H11_RS01555	COG0561	phosphatase activity
C4H11_RS01560	COG4771	TonB-dependent receptor
C4H11_RS01575	COG0556	nucleotide-excision repair
C4H11_RS01580	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C4H11_RS01615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4H11_RS01620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4H11_RS01625	COG3104	oligopeptide transport
C4H11_RS01640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4H11_RS01660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4H11_RS01665	COG2205	protein histidine kinase activity
C4H11_RS01670	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS01685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4H11_RS01695	COG0366	Alpha amylase catalytic
C4H11_RS01710	COG0351	phosphomethylpyrimidine kinase
C4H11_RS01730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4H11_RS01735	COG2022	thiamine diphosphate biosynthetic process
C4H11_RS01740	COG0352	thiamine-phosphate diphosphorylase activity
C4H11_RS01750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4H11_RS01760	COG2096	Adenosyltransferase
C4H11_RS01765	COG1797	cobyrinic acid a,c-diamide synthase activity
C4H11_RS01770	COG1660	Displays ATPase and GTPase activities
C4H11_RS01775	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4H11_RS01790	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
C4H11_RS01795	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4H11_RS01805	COG0542	response to heat
C4H11_RS01815	COG2855	membrane
C4H11_RS01840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4H11_RS01855	COG0543	2 iron, 2 sulfur cluster binding
C4H11_RS01860	COG0167	dihydroorotate dehydrogenase activity
C4H11_RS01865	COG0336	Belongs to the RNA methyltransferase TrmD family
C4H11_RS01870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4H11_RS01875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4H11_RS01900	COG0542	response to heat
C4H11_RS01945	COG2304	oxidoreductase activity
C4H11_RS01960	COG0714	Associated with various cellular activities
C4H11_RS01965	COG0776	regulation of translation
C4H11_RS01975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4H11_RS01980	COG0552	protein localization to endoplasmic reticulum
C4H11_RS01990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4H11_RS01995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4H11_RS02000	COG1546	Belongs to the CinA family
C4H11_RS02000	COG1058	Belongs to the CinA family
C4H11_RS02005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4H11_RS02015	COG0305	Participates in initiation and elongation during chromosome replication
C4H11_RS02020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4H11_RS02025	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4H11_RS02035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4H11_RS02045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4H11_RS02060	COG0577	efflux transmembrane transporter activity
C4H11_RS02060	COG1136	(ABC) transporter
C4H11_RS02070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4H11_RS02100	COG2205	protein histidine kinase activity
C4H11_RS02100	COG0745	RESPONSE REGULATOR receiver
C4H11_RS02100	COG3292	Two component regulator propeller
C4H11_RS02115	COG0463	Glycosyl transferase, family 2
C4H11_RS02130	COG1971	Probably functions as a manganese efflux pump
C4H11_RS02135	COG1477	protein flavinylation
C4H11_RS02155	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4H11_RS02220	COG1120	ATPase activity
C4H11_RS02225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4H11_RS02255	COG3250	beta-galactosidase activity
C4H11_RS02290	COG1695	Transcriptional regulator
C4H11_RS02295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4H11_RS02305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4H11_RS02315	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4H11_RS02335	COG1760	l-serine dehydratase
C4H11_RS02360	COG2433	Pfam Transposase IS66
C4H11_RS02375	COG0237	dephospho-CoA kinase activity
C4H11_RS02385	COG1862	Preprotein translocase
C4H11_RS02390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4H11_RS02400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4H11_RS02405	COG0193	aminoacyl-tRNA hydrolase activity
C4H11_RS02410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4H11_RS02415	COG0673	inositol 2-dehydrogenase activity
C4H11_RS02435	COG0321	lipoyl(octanoyl) transferase activity
C4H11_RS02440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C4H11_RS02445	COG4771	TonB-dependent receptor
C4H11_RS02455	COG0357	Ribosomal RNA small subunit methyltransferase G
C4H11_RS02460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4H11_RS02465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4H11_RS02465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4H11_RS02470	COG4232	protein-disulfide reductase activity
C4H11_RS02480	COG0572	uridine kinase
C4H11_RS02485	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4H11_RS02490	COG1410	methionine synthase
C4H11_RS02490	COG0646	methionine synthase
C4H11_RS02495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4H11_RS02530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4H11_RS02545	COG1678	Uncharacterized ACR, COG1678
C4H11_RS02565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4H11_RS02575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4H11_RS02580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4H11_RS02585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4H11_RS02590	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4H11_RS02595	COG0356	it plays a direct role in the translocation of protons across the membrane
C4H11_RS02600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4H11_RS02610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4H11_RS02610	COG0574	Belongs to the PEP-utilizing enzyme family
C4H11_RS02620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4H11_RS02625	COG0564	pseudouridine synthase activity
C4H11_RS02635	COG0024	Methionine aminopeptidase
C4H11_RS02645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4H11_RS02650	COG0481	GTPase activity
C4H11_RS02665	COG0708	Exodeoxyribonuclease III
C4H11_RS02680	COG0217	transcriptional regulatory protein
C4H11_RS02700	COG0842	Transport permease protein
C4H11_RS02705	COG1131	(ABC) transporter
C4H11_RS02740	COG1917	Cupin 2, conserved barrel domain protein
C4H11_RS02740	COG2207	Transcriptional regulator
C4H11_RS02765	COG3507	Belongs to the glycosyl hydrolase 43 family
C4H11_RS02770	COG0745	RESPONSE REGULATOR receiver
C4H11_RS02770	COG2205	protein histidine kinase activity
C4H11_RS02770	COG3292	Two component regulator propeller
C4H11_RS02780	COG1629	transport
C4H11_RS02785	COG0702	epimerase
C4H11_RS02790	COG1629	transport
C4H11_RS02795	COG0702	epimerase
C4H11_RS02800	COG3507	Belongs to the glycosyl hydrolase 43 family
C4H11_RS02825	COG2160	L-arabinose isomerase activity
C4H11_RS02840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4H11_RS02860	COG4191	Histidine kinase
C4H11_RS02865	COG3263	regulation of cellular component size
C4H11_RS02870	COG1022	Amp-dependent synthetase and ligase
C4H11_RS02880	COG1169	isochorismate synthase
C4H11_RS02885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C4H11_RS02890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C4H11_RS02905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4H11_RS02915	COG0512	Glutamine amidotransferase of anthranilate synthase
C4H11_RS02915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4H11_RS02925	COG0745	RESPONSE REGULATOR receiver
C4H11_RS02930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4H11_RS02955	COG0438	transferase activity, transferring glycosyl groups
C4H11_RS02985	COG1216	Glycosyl transferase, family 2
C4H11_RS02990	COG1216	Glycosyl transferase, family 2
C4H11_RS03095	COG4584	PFAM Integrase catalytic
C4H11_RS03100	COG1484	DNA-dependent DNA replication
C4H11_RS03220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4H11_RS03220	COG2205	protein histidine kinase activity
C4H11_RS03220	COG0784	Response regulator, receiver
C4H11_RS03220	COG2198	Histidine kinase
C4H11_RS03290	COG4974	Belongs to the 'phage' integrase family
C4H11_RS03300	COG1609	Transcriptional regulator
C4H11_RS03305	COG2721	sulfolactate sulfo-lyase activity
C4H11_RS03310	COG0228	four-way junction DNA binding
C4H11_RS03315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4H11_RS03320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4H11_RS03325	COG1328	CTP reductase activity
C4H11_RS03335	COG0716	FMN binding
C4H11_RS03345	COG0058	SHG alpha-glucan phosphorylase activity
C4H11_RS03360	COG1269	ATP hydrolysis coupled proton transport
C4H11_RS03375	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C4H11_RS03430	COG4206	TonB-dependent receptor
C4H11_RS03430	COG1629	transport
C4H11_RS03465	COG1032	radical SAM domain protein
C4H11_RS03475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4H11_RS03480	COG0463	Glycosyl transferase, family 2
C4H11_RS03485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4H11_RS03490	COG1410	methionine synthase
C4H11_RS03490	COG0646	methionine synthase
C4H11_RS03505	COG1408	metallophosphoesterase
C4H11_RS03520	COG0641	radical SAM
C4H11_RS03525	COG3591	Belongs to the peptidase S1B family
C4H11_RS03530	COG3591	Belongs to the peptidase S1B family
C4H11_RS03550	COG0488	(ABC) transporter
C4H11_RS03565	COG1629	transport
C4H11_RS03565	COG4206	TonB-dependent receptor
C4H11_RS03570	COG1629	transport
C4H11_RS03570	COG4206	TonB-dependent receptor
C4H11_RS03590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4H11_RS03595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4H11_RS03600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4H11_RS03605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4H11_RS03620	COG4864	UPF0365 protein
C4H11_RS03635	COG0037	tRNA processing
C4H11_RS03655	COG0612	Peptidase, M16
C4H11_RS03660	COG0110	maltose O-acetyltransferase activity
C4H11_RS03665	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS03675	COG0667	Aldo Keto reductase
C4H11_RS03700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4H11_RS03705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4H11_RS03715	COG1864	DNA RNA non-specific endonuclease
C4H11_RS03715	COG3591	Belongs to the peptidase S1B family
C4H11_RS03725	COG1629	transport
C4H11_RS03725	COG4206	TonB-dependent receptor
C4H11_RS03730	COG0488	(ABC) transporter
C4H11_RS03740	COG3345	alpha-galactosidase
C4H11_RS03750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4H11_RS03760	COG1271	oxidase subunit
C4H11_RS03775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4H11_RS03780	COG1136	(ABC) transporter
C4H11_RS03785	COG1136	(ABC) transporter
C4H11_RS03785	COG0577	efflux transmembrane transporter activity
C4H11_RS03795	COG3279	Response regulator of the LytR AlgR family
C4H11_RS03800	COG0363	glucosamine-6-phosphate deaminase activity
C4H11_RS03805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4H11_RS03810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C4H11_RS03815	COG3292	Two component regulator propeller
C4H11_RS03815	COG2205	protein histidine kinase activity
C4H11_RS03815	COG0745	RESPONSE REGULATOR receiver
C4H11_RS03820	COG1629	transport
C4H11_RS03820	COG4206	TonB-dependent receptor
C4H11_RS03830	COG2205	protein histidine kinase activity
C4H11_RS03830	COG3292	Two component regulator propeller
C4H11_RS03830	COG0745	RESPONSE REGULATOR receiver
C4H11_RS03850	COG4771	TonB-dependent receptor
C4H11_RS03865	COG0673	inositol 2-dehydrogenase activity
C4H11_RS03870	COG3458	cephalosporin-C deacetylase activity
C4H11_RS03875	COG2755	lipolytic protein G-D-S-L family
C4H11_RS03880	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C4H11_RS03885	COG3775	system Galactitol-specific IIC component
C4H11_RS03890	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C4H11_RS03895	COG2271	Major facilitator Superfamily
C4H11_RS03905	COG0799	negative regulation of ribosome biogenesis
C4H11_RS03910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4H11_RS03925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4H11_RS03930	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4H11_RS03935	COG1192	Involved in chromosome partitioning
C4H11_RS03940	COG1475	DNA binding
C4H11_RS03950	COG1388	LysM domain
C4H11_RS03950	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4H11_RS03955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4H11_RS03990	COG0739	heme binding
C4H11_RS04015	COG0742	ribosomal rna small subunit methyltransferase
C4H11_RS04020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4H11_RS04035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4H11_RS04080	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS04115	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4H11_RS04130	COG4206	TonB-dependent receptor
C4H11_RS04130	COG1629	transport
C4H11_RS04145	COG3537	Alpha-1,2-mannosidase
C4H11_RS04150	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C4H11_RS04155	COG2211	Major facilitator Superfamily
C4H11_RS04165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4H11_RS04180	COG0546	phosphoglycolate phosphatase activity
C4H11_RS04185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4H11_RS04195	COG0440	acetolactate synthase activity
C4H11_RS04205	COG0129	dihydroxy-acid dehydratase activity
C4H11_RS04220	COG3250	beta-galactosidase activity
C4H11_RS04230	COG5492	domain, Protein
C4H11_RS04240	COG4771	TonB-dependent receptor
C4H11_RS04245	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C4H11_RS04255	COG1047	Peptidyl-prolyl cis-trans
C4H11_RS04260	COG3681	Belongs to the UPF0597 family
C4H11_RS04265	COG3385	transposase activity
C4H11_RS04285	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS04300	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS04305	COG3408	Glycogen debranching enzyme
C4H11_RS04305	COG3119	arylsulfatase activity
C4H11_RS04310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4H11_RS04310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4H11_RS04315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4H11_RS04320	COG0776	regulation of translation
C4H11_RS04325	COG1530	ribonuclease E activity
C4H11_RS04335	COG4771	TonB-dependent receptor
C4H11_RS04345	COG0352	thiamine-phosphate diphosphorylase activity
C4H11_RS04360	COG1074	ATP-dependent DNA helicase activity
C4H11_RS04370	COG4139	cobalamin transport
C4H11_RS04385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4H11_RS04390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4H11_RS04470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4H11_RS04475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4H11_RS04480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4H11_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
C4H11_RS04495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4H11_RS04525	COG2801	Transposase and inactivated derivatives
C4H11_RS04545	COG2089	acid synthase
C4H11_RS04550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4H11_RS04555	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4H11_RS04560	COG1086	Polysaccharide biosynthesis protein
C4H11_RS04575	COG0191	fructose-bisphosphate aldolase activity
C4H11_RS04585	COG1215	transferase activity, transferring glycosyl groups
C4H11_RS04590	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4H11_RS04595	COG0436	Aminotransferase
C4H11_RS04605	COG0784	Response regulator, receiver
C4H11_RS04605	COG2205	protein histidine kinase activity
C4H11_RS04625	COG1136	(ABC) transporter
C4H11_RS04625	COG0577	efflux transmembrane transporter activity
C4H11_RS04630	COG1136	(ABC) transporter
C4H11_RS04640	COG0577	efflux transmembrane transporter activity
C4H11_RS04640	COG1136	(ABC) transporter
C4H11_RS04645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4H11_RS04650	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4H11_RS04650	COG3951	Flagellar rod assembly protein muramidase FlgJ
C4H11_RS04655	COG0295	cytidine deaminase activity
C4H11_RS04665	COG1082	Xylose isomerase domain protein TIM barrel
C4H11_RS04670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4H11_RS04675	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4H11_RS04680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4H11_RS04685	COG0254	rRNA binding
C4H11_RS04695	COG1918	ferrous iron import across plasma membrane
C4H11_RS04695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C4H11_RS04710	COG3328	transposase activity
C4H11_RS04895	COG3385	transposase activity
C4H11_RS04915	COG2433	Pfam Transposase IS66
C4H11_RS04945	COG3385	transposase activity
C4H11_RS04950	COG4974	Belongs to the 'phage' integrase family
C4H11_RS04960	COG0443	Heat shock 70 kDa protein
C4H11_RS04980	COG2161	toxin-antitoxin pair type II binding
C4H11_RS05000	COG1966	Carbon starvation protein
C4H11_RS05005	COG1649	PFAM Uncharacterised BCR, COG1649
C4H11_RS05045	COG4206	TonB-dependent receptor
C4H11_RS05045	COG1629	transport
C4H11_RS05050	COG0745	RESPONSE REGULATOR receiver
C4H11_RS05050	COG2205	protein histidine kinase activity
C4H11_RS05050	COG3292	Two component regulator propeller
C4H11_RS05065	COG1621	beta-fructofuranosidase activity
C4H11_RS05075	COG4206	TonB-dependent receptor
C4H11_RS05075	COG1629	transport
C4H11_RS05120	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4H11_RS05130	COG2086	electron transfer activity
C4H11_RS05135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4H11_RS05170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4H11_RS05210	COG1373	ATPase (AAA superfamily
C4H11_RS05225	COG4584	PFAM Integrase catalytic
C4H11_RS05230	COG1484	DNA-dependent DNA replication
C4H11_RS05270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4H11_RS05285	COG0514	ATP-dependent DNA helicase (RecQ)
C4H11_RS05310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4H11_RS05335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4H11_RS05340	COG0459	protein refolding
C4H11_RS05350	COG1078	dGTPase activity
C4H11_RS05355	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4H11_RS05360	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4H11_RS05360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4H11_RS05365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4H11_RS05375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4H11_RS05385	COG0442	prolyl-tRNA aminoacylation
C4H11_RS05425	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4H11_RS05430	COG0205	6-phosphofructokinase activity
C4H11_RS05435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4H11_RS05440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4H11_RS05460	COG0084	hydrolase, TatD family'
C4H11_RS05470	COG0811	peptide transport
C4H11_RS05500	COG1522	sequence-specific DNA binding
C4H11_RS05510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4H11_RS05540	COG1595	DNA-templated transcription, initiation
C4H11_RS05555	COG4771	TonB-dependent receptor
C4H11_RS05595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4H11_RS05605	COG0737	Belongs to the 5'-nucleotidase family
C4H11_RS05610	COG0737	Belongs to the 5'-nucleotidase family
C4H11_RS05615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4H11_RS05620	COG1472	Belongs to the glycosyl hydrolase 3 family
C4H11_RS05625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4H11_RS05630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4H11_RS05635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4H11_RS05645	COG0543	2 iron, 2 sulfur cluster binding
C4H11_RS05650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C4H11_RS05655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4H11_RS05660	COG0297	glycogen (starch) synthase activity
C4H11_RS05675	COG0438	transferase activity, transferring glycosyl groups
C4H11_RS05695	COG0519	Catalyzes the synthesis of GMP from XMP
C4H11_RS05695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4H11_RS05715	COG1970	mechanosensitive ion channel activity
C4H11_RS05725	COG0339	signal peptide processing
C4H11_RS05735	COG2131	deaminase
C4H11_RS05740	COG0793	Belongs to the peptidase S41A family
C4H11_RS05745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4H11_RS05765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4H11_RS05810	COG4372	Transposase
C4H11_RS05840	COG3385	transposase activity
C4H11_RS05855	COG0202	RNA polymerase activity
C4H11_RS05860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4H11_RS05865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4H11_RS05870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4H11_RS05875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4H11_RS05880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4H11_RS05895	COG0200	Binds to the 23S rRNA
C4H11_RS05900	COG1841	ribosomal large subunit assembly
C4H11_RS05905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4H11_RS05910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4H11_RS05915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4H11_RS05920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4H11_RS05925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4H11_RS05930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4H11_RS05935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4H11_RS05940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4H11_RS05945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4H11_RS05950	COG0255	Belongs to the universal ribosomal protein uL29 family
C4H11_RS05955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4H11_RS05960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4H11_RS05965	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4H11_RS05970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4H11_RS05975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4H11_RS05980	COG0089	rRNA binding
C4H11_RS05985	COG0088	Forms part of the polypeptide exit tunnel
C4H11_RS05990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4H11_RS05995	COG0051	transcription antitermination factor activity, RNA binding
C4H11_RS06000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4H11_RS06005	COG0049	tRNA binding
C4H11_RS06010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4H11_RS06020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4H11_RS06025	COG0085	RNA polymerase activity
C4H11_RS06030	COG0222	ribosome binding
C4H11_RS06035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4H11_RS06040	COG0081	regulation of translation
C4H11_RS06045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4H11_RS06090	COG4974	Belongs to the 'phage' integrase family
C4H11_RS06095	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4H11_RS06100	COG0006	proline dipeptidase activity
C4H11_RS06105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4H11_RS06115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4H11_RS06120	COG1480	7TM receptor with intracellular HD hydrolase
C4H11_RS06130	COG1196	nuclear chromosome segregation
C4H11_RS06135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4H11_RS06165	COG0514	ATP-dependent DNA helicase (RecQ)
C4H11_RS06180	COG2096	Adenosyltransferase
C4H11_RS06200	COG4206	TonB-dependent receptor
C4H11_RS06200	COG1629	transport
C4H11_RS06205	COG4977	sequence-specific DNA binding
C4H11_RS06210	COG1501	Belongs to the glycosyl hydrolase 31 family
C4H11_RS06215	COG0745	RESPONSE REGULATOR receiver
C4H11_RS06215	COG3292	Two component regulator propeller
C4H11_RS06215	COG2205	protein histidine kinase activity
C4H11_RS06270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4H11_RS06285	COG0492	ferredoxin-NADP+ reductase activity
C4H11_RS06285	COG3118	belongs to the thioredoxin family
C4H11_RS06310	COG0489	protein tyrosine kinase activity
C4H11_RS06315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4H11_RS06320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4H11_RS06330	COG1570	exodeoxyribonuclease VII activity
C4H11_RS06340	COG0482	sulfurtransferase activity
C4H11_RS06350	COG4206	TonB-dependent receptor
C4H11_RS06385	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C4H11_RS06390	COG4206	TonB-dependent receptor
C4H11_RS06390	COG1629	transport
C4H11_RS06395	COG0745	RESPONSE REGULATOR receiver
C4H11_RS06395	COG2205	protein histidine kinase activity
C4H11_RS06395	COG3292	Two component regulator propeller
C4H11_RS06400	COG3250	beta-galactosidase activity
C4H11_RS06415	COG4948	Mandelate Racemase Muconate Lactonizing
C4H11_RS06435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4H11_RS06470	COG2095	MarC family integral membrane protein
C4H11_RS06485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C4H11_RS06500	COG0628	permease
C4H11_RS06530	COG0537	adenosine 5'-monophosphoramidase activity
C4H11_RS06535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4H11_RS06545	COG1185	polyribonucleotide nucleotidyltransferase activity
C4H11_RS06555	COG3426	butyrate kinase activity
C4H11_RS06560	COG0280	phosphate acetyltransferase
C4H11_RS06575	COG2166	iron-sulfur cluster assembly
C4H11_RS06580	COG3655	Transcriptional regulator
C4H11_RS06590	COG1266	CAAX protease self-immunity
C4H11_RS06595	COG1629	transport
C4H11_RS06595	COG4206	TonB-dependent receptor
C4H11_RS06605	COG0196	riboflavin kinase activity
C4H11_RS06610	COG1011	Hydrolase
C4H11_RS06615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4H11_RS06620	COG1773	rubredoxin
C4H11_RS06625	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4H11_RS06630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4H11_RS06655	COG0006	proline dipeptidase activity
C4H11_RS06675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C4H11_RS06680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4H11_RS06720	COG1629	transport
C4H11_RS06735	COG2814	Major facilitator Superfamily
C4H11_RS06750	COG0793	Belongs to the peptidase S41A family
C4H11_RS06785	COG2176	DNA-directed DNA polymerase activity
C4H11_RS06790	COG2816	NAD+ diphosphatase activity
C4H11_RS06810	COG0018	arginyl-trna synthetase
C4H11_RS06835	COG0339	signal peptide processing
C4H11_RS06840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4H11_RS06850	COG2211	Major facilitator Superfamily
C4H11_RS06860	COG3661	Belongs to the glycosyl hydrolase 67 family
C4H11_RS06870	COG0732	type I restriction modification DNA specificity domain
C4H11_RS06875	COG4584	PFAM Integrase catalytic
C4H11_RS06880	COG1484	DNA-dependent DNA replication
C4H11_RS06890	COG2205	protein histidine kinase activity
C4H11_RS06890	COG3292	Two component regulator propeller
C4H11_RS06890	COG0745	RESPONSE REGULATOR receiver
C4H11_RS06895	COG3507	Belongs to the glycosyl hydrolase 43 family
C4H11_RS06900	COG2382	esterase
C4H11_RS06910	COG1472	Belongs to the glycosyl hydrolase 3 family
C4H11_RS06935	COG0702	epimerase
C4H11_RS06940	COG4206	TonB-dependent receptor
C4H11_RS06940	COG1629	transport
C4H11_RS06945	COG0561	phosphatase activity
C4H11_RS06950	COG4771	TonB-dependent receptor
C4H11_RS06955	COG3507	Belongs to the glycosyl hydrolase 43 family
C4H11_RS06970	COG0488	(ABC) transporter
C4H11_RS06975	COG3590	peptidase
C4H11_RS06985	COG0138	bifunctional purine biosynthesis protein purh
C4H11_RS07010	COG0772	Belongs to the SEDS family
C4H11_RS07020	COG1774	PSP1 C-terminal conserved region
C4H11_RS07025	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS07035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4H11_RS07050	COG0826	peptidase U32
C4H11_RS07060	COG4771	TonB-dependent receptor
C4H11_RS07100	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4H11_RS07105	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C4H11_RS07120	COG0252	asparaginase activity
C4H11_RS07130	COG0460	homoserine dehydrogenase
C4H11_RS07130	COG0527	aspartate kinase activity
C4H11_RS07135	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
C4H11_RS07145	COG1381	Involved in DNA repair and RecF pathway recombination
C4H11_RS07160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4H11_RS07165	COG0849	cell division
C4H11_RS07175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4H11_RS07180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4H11_RS07185	COG0772	Belongs to the SEDS family
C4H11_RS07190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4H11_RS07195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4H11_RS07200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4H11_RS07205	COG0768	penicillin binding
C4H11_RS07220	COG2001	Belongs to the MraZ family
C4H11_RS07225	COG1595	DNA-templated transcription, initiation
C4H11_RS07245	COG0756	dUTP diphosphatase activity
C4H11_RS07265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4H11_RS07275	COG1022	Amp-dependent synthetase and ligase
C4H11_RS07280	COG0612	Peptidase, M16
C4H11_RS07285	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4H11_RS07290	COG1785	Belongs to the alkaline phosphatase family
C4H11_RS07295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4H11_RS07305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4H11_RS07320	COG1136	(ABC) transporter
C4H11_RS07325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4H11_RS07330	COG0475	glutathione-regulated potassium exporter activity
C4H11_RS07330	COG0589	response to stress
C4H11_RS07335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4H11_RS07355	COG3485	protocatechuate 3,4-dioxygenase
C4H11_RS07370	COG1151	hydroxylamine reductase activity
C4H11_RS07390	COG4206	TonB-dependent receptor
C4H11_RS07390	COG1629	transport
C4H11_RS07395	COG0702	epimerase
C4H11_RS07400	COG3876	Protein conserved in bacteria
C4H11_RS07405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4H11_RS07415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4H11_RS07420	COG1216	Glycosyl transferase, family 2
C4H11_RS07420	COG0463	Glycosyl transferase, family 2
C4H11_RS07450	COG3876	Protein conserved in bacteria
C4H11_RS07475	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C4H11_RS07490	COG0423	glycine-tRNA ligase activity
C4H11_RS07530	COG2954	triphosphatase activity
C4H11_RS07550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4H11_RS07565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4H11_RS07575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4H11_RS07580	COG0438	transferase activity, transferring glycosyl groups
C4H11_RS07585	COG1216	Glycosyl transferase, family 2
C4H11_RS07590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4H11_RS07605	COG0545	Peptidyl-prolyl cis-trans isomerase
C4H11_RS07610	COG0545	Peptidyl-prolyl cis-trans isomerase
C4H11_RS07615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4H11_RS07620	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4H11_RS07620	COG0517	IMP dehydrogenase activity
C4H11_RS07630	COG1028	Short-chain dehydrogenase reductase Sdr
C4H11_RS07635	COG2910	NAD(P)H-binding
C4H11_RS07640	COG1733	regulation of RNA biosynthetic process
C4H11_RS07645	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4H11_RS07655	COG1131	(ABC) transporter
C4H11_RS07680	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS07700	COG5492	domain, Protein
C4H11_RS07705	COG0783	Belongs to the Dps family
C4H11_RS07720	COG3634	alkyl hydroperoxide reductase activity
C4H11_RS07725	COG0612	Peptidase, M16
C4H11_RS07730	COG1592	Rubrerythrin
C4H11_RS07735	COG0659	secondary active sulfate transmembrane transporter activity
C4H11_RS07750	COG2252	PERMEase
C4H11_RS07765	COG4771	TonB-dependent receptor
C4H11_RS07785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4H11_RS07795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4H11_RS07825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4H11_RS07825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4H11_RS07855	COG3250	beta-galactosidase activity
C4H11_RS07860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4H11_RS07870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4H11_RS07880	COG1396	sequence-specific DNA binding
C4H11_RS07880	COG1917	Cupin 2, conserved barrel domain protein
C4H11_RS07885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4H11_RS07900	COG0564	pseudouridine synthase activity
C4H11_RS07945	COG0205	6-phosphofructokinase activity
C4H11_RS07950	COG0571	ribonuclease III activity
C4H11_RS07955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4H11_RS07960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4H11_RS07965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4H11_RS08030	COG1028	Short-chain dehydrogenase reductase Sdr
C4H11_RS08035	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C4H11_RS08040	COG4771	TonB-dependent receptor
C4H11_RS08045	COG1217	gtp-binding protein TYPA
C4H11_RS08050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4H11_RS08070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4H11_RS08075	COG0793	Belongs to the peptidase S41A family
C4H11_RS08075	COG3409	Peptidoglycan-binding domain 1 protein
C4H11_RS08090	COG1053	succinate dehydrogenase
C4H11_RS08095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4H11_RS08100	COG0671	phosphoesterase, PA-phosphatase related
C4H11_RS08105	COG0584	glycerophosphoryl diester phosphodiesterase
C4H11_RS08110	COG0758	DNA mediated transformation
C4H11_RS08120	COG0826	peptidase U32
C4H11_RS08130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4H11_RS08135	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4H11_RS08145	COG0606	chelatase, subunit chli
C4H11_RS08160	COG4974	Belongs to the 'phage' integrase family
C4H11_RS08165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4H11_RS08180	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4H11_RS08185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4H11_RS08195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4H11_RS08200	COG1854	S-ribosylhomocysteine lyase activity
C4H11_RS08225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4H11_RS08240	COG0318	PFAM AMP-dependent synthetase and ligase
C4H11_RS08255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4H11_RS08260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4H11_RS08265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4H11_RS08270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4H11_RS08280	COG0495	leucyl-tRNA aminoacylation
C4H11_RS08285	COG0697	spore germination
C4H11_RS08295	COG2755	lipolytic protein G-D-S-L family
C4H11_RS08295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4H11_RS08315	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4H11_RS08325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4H11_RS08330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4H11_RS08345	COG0012	GTP binding
C4H11_RS08355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4H11_RS08355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4H11_RS08360	COG0142	geranyltranstransferase activity
C4H11_RS08370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4H11_RS08375	COG1694	Mazg nucleotide pyrophosphohydrolase
C4H11_RS08380	COG1490	D-aminoacyl-tRNA deacylase activity
C4H11_RS08385	COG0322	excinuclease ABC activity
C4H11_RS08390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4H11_RS08410	COG3291	Pkd domain containing protein
C4H11_RS08435	COG0745	RESPONSE REGULATOR receiver
C4H11_RS08435	COG2205	protein histidine kinase activity
C4H11_RS08435	COG3292	Two component regulator propeller
C4H11_RS08440	COG1629	transport
C4H11_RS08440	COG4206	TonB-dependent receptor
C4H11_RS08460	COG3507	Belongs to the glycosyl hydrolase 43 family
C4H11_RS08480	COG4771	TonB-dependent receptor
C4H11_RS08495	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4H11_RS08500	COG2715	membrane protein required for spore maturation
C4H11_RS08505	COG2234	aminopeptidase activity
C4H11_RS08525	COG4771	TonB-dependent receptor
C4H11_RS08535	COG5492	domain, Protein
C4H11_RS08540	COG3119	arylsulfatase activity
C4H11_RS08545	COG2205	protein histidine kinase activity
C4H11_RS08545	COG3292	Two component regulator propeller
C4H11_RS08545	COG2205	protein histidine kinase activity
C4H11_RS08545	COG0745	RESPONSE REGULATOR receiver
C4H11_RS08545	COG0745	RESPONSE REGULATOR receiver
C4H11_RS08545	COG3292	Two component regulator propeller
C4H11_RS08580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C4H11_RS08585	COG3119	arylsulfatase activity
C4H11_RS08590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4H11_RS08595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4H11_RS08600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4H11_RS08610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4H11_RS08630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4H11_RS08650	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C4H11_RS08655	COG2271	Major facilitator Superfamily
C4H11_RS08665	COG0702	epimerase
C4H11_RS08670	COG1629	transport
C4H11_RS08690	COG0562	UDP-galactopyranose mutase
C4H11_RS08695	COG0438	transferase activity, transferring glycosyl groups
C4H11_RS08715	COG1368	sulfuric ester hydrolase activity
C4H11_RS08720	COG1132	(ABC) transporter
C4H11_RS08730	COG3119	arylsulfatase activity
C4H11_RS08740	COG0328	RNA-DNA hybrid ribonuclease activity
C4H11_RS08740	COG3341	Caulimovirus viroplasmin
C4H11_RS08750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4H11_RS08755	COG1166	arginine decarboxylase activity
C4H11_RS08760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4H11_RS08765	COG1595	DNA-templated transcription, initiation
C4H11_RS08790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4H11_RS08795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4H11_RS08800	COG2382	esterase
C4H11_RS08800	COG3507	Belongs to the glycosyl hydrolase 43 family
C4H11_RS08800	COG3693	PFAM glycoside hydrolase, family 10
C4H11_RS08805	COG2382	esterase
C4H11_RS08805	COG3693	PFAM glycoside hydrolase, family 10
C4H11_RS08810	COG1472	Belongs to the glycosyl hydrolase 3 family
C4H11_RS08830	COG1940	carbohydrate kinase activity
C4H11_RS08845	COG2814	Major facilitator Superfamily
C4H11_RS08850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4H11_RS08870	COG0187	DNA topoisomerase II activity
C4H11_RS08875	COG0268	Binds directly to 16S ribosomal RNA
C4H11_RS08885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4H11_RS08900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4H11_RS08930	COG0681	Belongs to the peptidase S26 family
C4H11_RS08940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4H11_RS08950	COG2255	four-way junction helicase activity
C4H11_RS08965	COG3591	Belongs to the peptidase S1B family
C4H11_RS08970	COG1045	serine acetyltransferase
C4H11_RS08975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4H11_RS08975	COG0116	Belongs to the methyltransferase superfamily
C4H11_RS08980	COG1506	peptidase
C4H11_RS08980	COG0823	Involved in the tonB-independent uptake of proteins
C4H11_RS08985	COG0151	Belongs to the GarS family
C4H11_RS09000	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4H11_RS09000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4H11_RS09010	COG1121	(ABC) transporter
C4H11_RS09015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4H11_RS09020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4H11_RS09025	COG0137	argininosuccinate synthase activity
C4H11_RS09040	COG3119	arylsulfatase activity
C4H11_RS09055	COG1595	DNA-templated transcription, initiation
C4H11_RS09065	COG4206	TonB-dependent receptor
C4H11_RS09065	COG1629	transport
C4H11_RS09090	COG0534	Mate efflux family protein
C4H11_RS09095	COG0612	Peptidase, M16
C4H11_RS09100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4H11_RS09100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4H11_RS09180	COG1506	peptidase
C4H11_RS09180	COG0823	Involved in the tonB-independent uptake of proteins
C4H11_RS09185	COG0564	pseudouridine synthase activity
C4H11_RS09215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4H11_RS09225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4H11_RS09230	COG0594	ribonuclease P activity
C4H11_RS09270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4H11_RS09275	COG4584	PFAM Integrase catalytic
C4H11_RS09280	COG1484	DNA-dependent DNA replication
C4H11_RS09325	COG1629	transport
C4H11_RS09325	COG4206	TonB-dependent receptor
C4H11_RS09330	COG0702	epimerase
C4H11_RS09340	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C4H11_RS09345	COG3119	arylsulfatase activity
C4H11_RS09355	COG4206	TonB-dependent receptor
C4H11_RS09355	COG1629	transport
C4H11_RS09360	COG3250	beta-galactosidase activity
C4H11_RS09375	COG3408	Glycogen debranching enzyme
C4H11_RS09375	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C4H11_RS09380	COG3250	beta-galactosidase activity
C4H11_RS09385	COG2431	L-lysine efflux transmembrane transporter activity
C4H11_RS09395	COG0702	epimerase
C4H11_RS09400	COG1629	transport
C4H11_RS09400	COG4206	TonB-dependent receptor
C4H11_RS09415	COG0656	L-ascorbic acid biosynthetic process
C4H11_RS09430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4H11_RS09435	COG0280	phosphate acetyltransferase
C4H11_RS09440	COG1380	Effector of murein hydrolase LrgA
C4H11_RS09445	COG1346	cytolysis
C4H11_RS09465	COG0312	modulator of DNA gyrase
C4H11_RS09470	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C4H11_RS09475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4H11_RS09485	COG0297	glycogen (starch) synthase activity
C4H11_RS09520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4H11_RS09525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4H11_RS09530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4H11_RS09535	COG1968	undecaprenyl-diphosphatase activity
C4H11_RS09545	COG2177	Part of the ABC transporter FtsEX involved in
C4H11_RS09570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4H11_RS09580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4H11_RS09595	COG4206	TonB-dependent receptor
C4H11_RS09595	COG1629	transport
C4H11_RS09610	COG5434	Belongs to the glycosyl hydrolase 28 family
C4H11_RS09615	COG0513	Belongs to the DEAD box helicase family
C4H11_RS09635	COG0557	exoribonuclease II activity
C4H11_RS09660	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4H11_RS09660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4H11_RS09665	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4H11_RS09690	COG1136	(ABC) transporter
C4H11_RS09715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4H11_RS09730	COG0427	acetyl-CoA hydrolase
C4H11_RS09745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4H11_RS09745	COG0731	radical SAM domain protein
C4H11_RS09750	COG1522	sequence-specific DNA binding
C4H11_RS09795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4H11_RS09795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4H11_RS09800	COG2890	protein-(glutamine-N5) methyltransferase activity
C4H11_RS09810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4H11_RS09820	COG0165	Argininosuccinate lyase
C4H11_RS09835	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4H11_RS09840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4H11_RS09845	COG0463	Glycosyl transferase, family 2
C4H11_RS09845	COG1216	Glycosyl transferase, family 2
C4H11_RS09850	COG2003	Belongs to the UPF0758 family
C4H11_RS09865	COG4771	TonB-dependent receptor
C4H11_RS09870	COG4974	Belongs to the 'phage' integrase family
C4H11_RS09875	COG1629	transport
C4H11_RS09880	COG0702	epimerase
C4H11_RS09900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4H11_RS09910	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C4H11_RS09910	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4H11_RS09920	COG1162	GTPase activity
C4H11_RS09925	COG0233	cytoplasmic translational termination
C4H11_RS09930	COG0528	UMP kinase activity
C4H11_RS09935	COG2217	Heavy metal translocating P-type atpase
C4H11_RS09945	COG2375	cellular response to nickel ion
C4H11_RS09945	COG1132	(ABC) transporter
C4H11_RS09950	COG1132	(ABC) transporter
C4H11_RS09955	COG0534	Mate efflux family protein
C4H11_RS09990	COG0792	nuclease activity
C4H11_RS10040	COG1609	Transcriptional regulator
C4H11_RS10040	COG2207	Transcriptional regulator
C4H11_RS10065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4H11_RS10075	COG3325	Belongs to the glycosyl hydrolase 18 family
C4H11_RS10075	COG3469	chitinase activity
C4H11_RS10085	COG4771	TonB-dependent receptor
C4H11_RS10105	COG1183	phosphatidylcholine synthase activity
C4H11_RS10110	COG0688	phosphatidylethanolamine metabolic process
C4H11_RS10140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4H11_RS10150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4H11_RS10160	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4H11_RS10170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4H11_RS10175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4H11_RS10210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4H11_RS10220	COG1228	amidohydrolase
C4H11_RS10230	COG2986	histidine ammonia-lyase
C4H11_RS10235	COG1309	transcriptional regulator
C4H11_RS10245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4H11_RS10270	COG1696	Membrane protein involved in D-alanine export
C4H11_RS10320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4H11_RS10325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4H11_RS10330	COG1160	GTP binding
C4H11_RS10335	COG1127	ABC transporter
C4H11_RS10340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4H11_RS10360	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4H11_RS10365	COG0740	serine-type endopeptidase activity
C4H11_RS10370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4H11_RS10380	COG0516	GMP reductase activity
C4H11_RS10380	COG0517	IMP dehydrogenase activity
C4H11_RS10405	COG0592	DNA-directed DNA polymerase activity
C4H11_RS10615	COG1475	DNA binding
C4H11_RS10620	COG3969	phosphoadenosine phosphosulfate
C4H11_RS10775	COG1187	pseudouridine synthase activity
C4H11_RS10780	COG0017	Asparaginyl-tRNA synthetase
C4H11_RS10790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4H11_RS10795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4H11_RS10800	COG0052	Belongs to the universal ribosomal protein uS2 family
C4H11_RS10805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4H11_RS10815	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C4H11_RS10820	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4H11_RS10825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4H11_RS10880	COG0463	Glycosyl transferase, family 2
C4H11_RS10900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4H11_RS10905	COG2502	aspartate--ammonia ligase
C4H11_RS10915	COG4124	Belongs to the glycosyl hydrolase 26 family
C4H11_RS10920	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C4H11_RS10925	COG2211	Major facilitator Superfamily
C4H11_RS10930	COG2942	2-epimerase
C4H11_RS10935	COG0583	DNA-binding transcription factor activity
C4H11_RS10940	COG3610	response to peptide
C4H11_RS10945	COG2966	Psort location CytoplasmicMembrane, score
C4H11_RS10960	COG1629	transport
C4H11_RS10960	COG4206	TonB-dependent receptor
C4H11_RS10965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C4H11_RS10975	COG0745	RESPONSE REGULATOR receiver
C4H11_RS10975	COG3292	Two component regulator propeller
C4H11_RS10975	COG2205	protein histidine kinase activity
C4H11_RS10995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4H11_RS11000	COG0436	Aminotransferase
C4H11_RS11010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4H11_RS11025	COG0363	glucosamine-6-phosphate deaminase activity
C4H11_RS11030	COG4953	penicillin-binding protein 1C
C4H11_RS11035	COG2373	Large extracellular alpha-helical protein
C4H11_RS11040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4H11_RS11060	COG3757	hydrolase, family 25
C4H11_RS11065	COG2264	protein methyltransferase activity
C4H11_RS11100	COG1592	Rubrerythrin
C4H11_RS11100	COG1773	rubredoxin
C4H11_RS11110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4H11_RS11110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4H11_RS11115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4H11_RS11230	COG1492	cobalamin metabolic process
C4H11_RS11235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4H11_RS11265	COG4206	TonB-dependent receptor
C4H11_RS11265	COG1629	transport
C4H11_RS11270	COG1979	alcohol dehydrogenase
C4H11_RS11280	COG0823	Involved in the tonB-independent uptake of proteins
C4H11_RS11280	COG1506	peptidase
C4H11_RS11300	COG2115	Belongs to the xylose isomerase family
C4H11_RS11305	COG0477	Major facilitator Superfamily
C4H11_RS11305	COG2814	Major facilitator Superfamily
C4H11_RS11310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4H11_RS11320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4H11_RS11335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4H11_RS11355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4H11_RS11360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4H11_RS11370	COG0037	tRNA processing
C4H11_RS11380	COG2226	methyltransferase
C4H11_RS11395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4H11_RS11395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4H11_RS11435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4H11_RS11465	COG1917	Cupin 2, conserved barrel domain protein
C4H11_RS11465	COG4977	sequence-specific DNA binding
C4H11_RS11475	COG0166	Belongs to the GPI family
C4H11_RS11480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4H11_RS11485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4H11_RS11490	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4H11_RS11500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4H11_RS11515	COG1640	4-alpha-glucanotransferase
C4H11_RS11520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4H11_RS11555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4H11_RS11560	COG0318	PFAM AMP-dependent synthetase and ligase
C4H11_RS11570	COG0359	binds to the 23S rRNA
C4H11_RS11575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4H11_RS11580	COG0360	Binds together with S18 to 16S ribosomal RNA
C4H11_RS11605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4H11_RS11615	COG1312	Catalyzes the dehydration of D-mannonate
C4H11_RS11670	COG1234	tRNA 3'-trailer cleavage
C4H11_RS11675	COG1595	DNA-templated transcription, initiation
C4H11_RS11690	COG3956	TIGRFAM MazG family protein
C4H11_RS11700	COG0525	valine-tRNA ligase activity
C4H11_RS11715	COG0653	protein targeting
C4H11_RS11720	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
C4H11_RS11765	COG1253	flavin adenine dinucleotide binding
C4H11_RS11770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4H11_RS11775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4H11_RS11785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4H11_RS11825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C4H11_RS11835	COG4771	TonB-dependent receptor
C4H11_RS11840	COG0745	RESPONSE REGULATOR receiver
C4H11_RS11840	COG2205	protein histidine kinase activity
C4H11_RS11840	COG3292	Two component regulator propeller
C4H11_RS11885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4H11_RS11885	COG0551	DNA topoisomerase type I activity
C4H11_RS11920	COG1132	(ABC) transporter
C4H11_RS11925	COG1132	(ABC) transporter
C4H11_RS11995	COG4584	PFAM Integrase catalytic
C4H11_RS12000	COG1484	DNA-dependent DNA replication
C4H11_RS12050	COG2226	methyltransferase
C4H11_RS12085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4H11_RS12170	COG2217	Heavy metal translocating P-type atpase
C4H11_RS12205	COG0779	Required for maturation of 30S ribosomal subunits
C4H11_RS12210	COG0195	Participates in both transcription termination and antitermination
C4H11_RS12215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4H11_RS12225	COG0719	Fe-S assembly protein
C4H11_RS12230	COG0396	ATPase activity
C4H11_RS12240	COG0719	Fe-S assembly protein
C4H11_RS12255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4H11_RS12270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4H11_RS12275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4H11_RS12285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C4H11_RS12300	COG0101	tRNA pseudouridine synthase activity
C4H11_RS12310	COG3292	Two component regulator propeller
C4H11_RS12310	COG0745	RESPONSE REGULATOR receiver
C4H11_RS12310	COG2205	protein histidine kinase activity
C4H11_RS12315	COG3250	beta-galactosidase activity
C4H11_RS12320	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C4H11_RS12340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4H11_RS12340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4H11_RS12400	COG0009	L-threonylcarbamoyladenylate synthase
C4H11_RS12410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4H11_RS12415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4H11_RS12435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4H11_RS12480	COG0335	large ribosomal subunit rRNA binding
C4H11_RS12505	COG3385	transposase activity
C4H11_RS12515	COG0039	L-malate dehydrogenase activity
C4H11_RS12540	COG0148	phosphopyruvate hydratase activity
C4H11_RS12595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4H11_RS12610	COG0848	biopolymer transport protein
C4H11_RS12625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4H11_RS12630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4H11_RS12635	COG0739	heme binding
C4H11_RS12650	COG0149	triose-phosphate isomerase activity
C4H11_RS12660	COG0302	gtp cyclohydrolase
C4H11_RS12665	COG0358	DNA primase activity
C4H11_RS12685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4H11_RS12690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C4H11_RS12700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4H11_RS12760	COG1484	DNA-dependent DNA replication
C4H11_RS12765	COG4584	PFAM Integrase catalytic
C4H11_RS12795	COG1242	4 iron, 4 sulfur cluster binding
C4H11_RS12805	COG0363	glucosamine-6-phosphate deaminase activity
C4H11_RS12840	COG3547	Transposase (IS116 IS110 IS902 family)
C4H11_RS12875	COG0681	Belongs to the peptidase S26 family
C4H11_RS12905	COG0673	inositol 2-dehydrogenase activity
C4H11_RS12910	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4H11_RS12925	COG1629	transport
C4H11_RS12925	COG4206	TonB-dependent receptor
C4H11_RS12965	COG1119	ATPase activity
C4H11_RS12975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4H11_RS12980	COG0569	domain protein
C4H11_RS12985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4H11_RS13000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4H11_RS13005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4H11_RS13010	COG0805	protein transport
C4H11_RS13025	COG0492	ferredoxin-NADP+ reductase activity
C4H11_RS13035	COG1674	ftsk spoiiie
C4H11_RS13040	COG1333	cytochrome c biogenesis protein
C4H11_RS13040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4H11_RS13065	COG3487	Iron-regulated protein
C4H11_RS13085	COG1073	alpha beta
C4H11_RS13095	COG0561	phosphatase activity
C4H11_RS13100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4H11_RS13105	COG0009	L-threonylcarbamoyladenylate synthase
C4H11_RS13110	COG1196	nuclear chromosome segregation
C4H11_RS13115	COG2239	Acts as a magnesium transporter
C4H11_RS13120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4H11_RS13135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4H11_RS13140	COG0436	Aminotransferase
C4H11_RS13155	COG2186	Transcriptional regulator
C4H11_RS13160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4H11_RS13165	COG4771	TonB-dependent receptor
C4H11_RS13170	COG0702	epimerase
C4H11_RS13185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4H11_RS13185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4H11_RS13190	COG3022	response to hydroperoxide
C4H11_RS13205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4H11_RS13210	COG0107	imidazoleglycerol-phosphate synthase activity
C4H11_RS13215	COG0140	phosphoribosyl-ATP diphosphatase activity
C4H11_RS13215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4H11_RS13220	COG2884	Cell division ATP-binding protein ftsE
C4H11_RS13225	COG0527	aspartate kinase activity
C4H11_RS13230	COG0019	diaminopimelate decarboxylase activity
C4H11_RS13250	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4H11_RS13255	COG0156	8-amino-7-oxononanoate synthase activity
C4H11_RS13270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4H11_RS13275	COG0321	lipoyl(octanoyl) transferase activity
C4H11_RS13275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4H11_RS13290	COG0592	DNA-directed DNA polymerase activity
C4H11_RS13305	COG0497	DNA recombination
C4H11_RS13310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4H11_RS13325	COG0285	dihydrofolate synthase activity
C4H11_RS13330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4H11_RS13340	COG0167	dihydroorotate dehydrogenase activity
C4H11_RS13345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4H11_RS13355	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C4H11_RS13360	COG0586	Pfam SNARE associated Golgi protein
C4H11_RS13370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4H11_RS13375	COG0307	riboflavin synthase, alpha
C4H11_RS13400	COG1554	hydrolase, family 65, central catalytic
C4H11_RS13425	COG1629	transport
C4H11_RS13425	COG4206	TonB-dependent receptor
C4H11_RS13430	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C4H11_RS13450	COG0534	Mate efflux family protein
C4H11_RS13470	COG1295	ribonuclease BN
C4H11_RS13485	COG4948	Mandelate Racemase Muconate Lactonizing
C4H11_RS13495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4H11_RS13500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4H11_RS13525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4H11_RS13565	COG0686	Belongs to the AlaDH PNT family
C4H11_RS13570	COG0739	heme binding
C4H11_RS13580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4H11_RS13600	COG3119	arylsulfatase activity
C4H11_RS13605	COG0318	PFAM AMP-dependent synthetase and ligase
C4H11_RS13620	COG1518	maintenance of DNA repeat elements
C4H11_RS13625	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C4H11_RS13630	COG2433	Pfam Transposase IS66
C4H11_RS13665	COG4974	Belongs to the 'phage' integrase family
C4H11_RS13675	COG1484	DNA-dependent DNA replication
C4H11_RS13680	COG4584	PFAM Integrase catalytic
C4H11_RS13710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4H11_RS13715	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4H11_RS13720	COG1663	tetraacyldisaccharide 4'-kinase activity
C4H11_RS13725	COG0616	signal peptide processing
C4H11_RS13765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4H11_RS13770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4H11_RS13775	COG0066	3-isopropylmalate dehydratase activity
C4H11_RS13795	COG0471	metal ion transport
C4H11_RS13795	COG0490	domain, Protein
C4H11_RS13810	COG0577	efflux transmembrane transporter activity
C4H11_RS13810	COG1136	(ABC) transporter
C4H11_RS13815	COG1136	(ABC) transporter
C4H11_RS13815	COG0577	efflux transmembrane transporter activity
C4H11_RS13820	COG1136	(ABC) transporter
C4H11_RS13820	COG0577	efflux transmembrane transporter activity
C4H11_RS13825	COG1940	carbohydrate kinase activity
C4H11_RS13830	COG2985	domain, Protein
C4H11_RS13830	COG0569	domain protein
C4H11_RS13835	COG1194	a g-specific adenine glycosylase
C4H11_RS13840	COG0629	single-stranded DNA binding
C4H11_RS13940	COG0504	CTP synthase activity
C4H11_RS13965	COG4656	Part of a membrane complex involved in electron transport
C4H11_RS13970	COG4658	electron transport chain
C4H11_RS13975	COG4659	FMN binding
C4H11_RS13980	COG4660	Part of a membrane complex involved in electron transport
C4H11_RS13985	COG4657	Part of a membrane complex involved in electron transport
C4H11_RS13990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4H11_RS13995	COG0366	Alpha amylase catalytic
C4H11_RS14005	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C4H11_RS14010	COG0511	ligase activity, forming carbon-carbon bonds
C4H11_RS14020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4H11_RS14035	COG2204	response regulator
C4H11_RS14045	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C4H11_RS14050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4H11_RS14050	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4H11_RS14050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4H11_RS14050	COG1013	pyruvate-flavodoxin oxidoreductase activity