locus-tag	class	description
CYPRO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYPRO_RS00010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CYPRO_RS00020	COG1428	Deoxynucleoside kinase
CYPRO_RS00045	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYPRO_RS00050	COG0740	serine-type endopeptidase activity
CYPRO_RS00055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYPRO_RS00070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CYPRO_RS00075	COG1196	nuclear chromosome segregation
CYPRO_RS00080	COG0233	cytoplasmic translational termination
CYPRO_RS00085	COG0528	UMP kinase activity
CYPRO_RS00090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYPRO_RS00095	COG0052	Belongs to the universal ribosomal protein uS2 family
CYPRO_RS00100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYPRO_RS00105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYPRO_RS00120	COG0540	Belongs to the ATCase OTCase family
CYPRO_RS00140	COG1388	LysM domain
CYPRO_RS00140	COG1705	Flagellar rod assembly protein muramidase FlgJ
CYPRO_RS00150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYPRO_RS00160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CYPRO_RS00165	COG1127	ABC transporter
CYPRO_RS00180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYPRO_RS00180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYPRO_RS00185	COG0307	riboflavin synthase, alpha
CYPRO_RS00195	COG0784	Response regulator, receiver
CYPRO_RS00195	COG5002	protein histidine kinase activity
CYPRO_RS00195	COG2198	Histidine kinase
CYPRO_RS00260	COG3177	Filamentation induced by cAMP protein fic
CYPRO_RS00270	COG2382	esterase
CYPRO_RS00285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYPRO_RS00295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CYPRO_RS00300	COG5002	protein histidine kinase activity
CYPRO_RS00300	COG0784	Response regulator, receiver
CYPRO_RS00300	COG2205	protein histidine kinase activity
CYPRO_RS00315	COG1187	pseudouridine synthase activity
CYPRO_RS00325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CYPRO_RS00335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CYPRO_RS00350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYPRO_RS00355	COG0039	L-malate dehydrogenase activity
CYPRO_RS00380	COG2957	Belongs to the agmatine deiminase family
CYPRO_RS00390	COG2819	hydrolase of the alpha beta superfamily
CYPRO_RS00405	COG1629	transport
CYPRO_RS00405	COG4206	TonB-dependent receptor
CYPRO_RS00410	COG3275	phosphorelay sensor kinase activity
CYPRO_RS00415	COG3279	Response regulator of the LytR AlgR family
CYPRO_RS00420	COG0784	Response regulator, receiver
CYPRO_RS00420	COG2205	protein histidine kinase activity
CYPRO_RS00420	COG5002	protein histidine kinase activity
CYPRO_RS00435	COG0606	chelatase, subunit chli
CYPRO_RS00465	COG2116	formate transmembrane transporter activity
CYPRO_RS00470	COG0488	(ABC) transporter
CYPRO_RS00475	COG2255	four-way junction helicase activity
CYPRO_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
CYPRO_RS00495	COG4124	Belongs to the glycosyl hydrolase 26 family
CYPRO_RS00500	COG1252	NADH dehydrogenase
CYPRO_RS00515	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CYPRO_RS00530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CYPRO_RS00535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYPRO_RS00540	COG1722	exodeoxyribonuclease VII activity
CYPRO_RS00545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYPRO_RS00555	COG1960	acyl-CoA dehydrogenase activity
CYPRO_RS00580	COG0564	pseudouridine synthase activity
CYPRO_RS00595	COG1629	transport
CYPRO_RS00595	COG4206	TonB-dependent receptor
CYPRO_RS00605	COG4772	TonB-dependent receptor
CYPRO_RS00610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CYPRO_RS00645	COG4771	TonB-dependent receptor
CYPRO_RS00655	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CYPRO_RS00660	COG2205	protein histidine kinase activity
CYPRO_RS00660	COG3437	response regulator, receiver
CYPRO_RS00660	COG3850	Histidine kinase
CYPRO_RS00660	COG4999	Histidine kinase
CYPRO_RS00670	COG1510	regulation of RNA biosynthetic process
CYPRO_RS00680	COG0577	efflux transmembrane transporter activity
CYPRO_RS00695	COG1136	(ABC) transporter
CYPRO_RS00710	COG1136	(ABC) transporter
CYPRO_RS00710	COG0577	efflux transmembrane transporter activity
CYPRO_RS00715	COG0577	efflux transmembrane transporter activity
CYPRO_RS00715	COG1136	(ABC) transporter
CYPRO_RS00730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYPRO_RS00735	COG2204	response regulator
CYPRO_RS00740	COG1757	Na H antiporter
CYPRO_RS00750	COG3237	CsbD-like
CYPRO_RS00770	COG0492	ferredoxin-NADP+ reductase activity
CYPRO_RS00785	COG4977	sequence-specific DNA binding
CYPRO_RS00850	COG2205	protein histidine kinase activity
CYPRO_RS00885	COG2234	aminopeptidase activity
CYPRO_RS00905	COG2972	Histidine kinase
CYPRO_RS00910	COG3279	Response regulator of the LytR AlgR family
CYPRO_RS00915	COG1373	ATPase (AAA superfamily
CYPRO_RS00920	COG1228	amidohydrolase
CYPRO_RS00925	COG0445	tRNA wobble uridine modification
CYPRO_RS00930	COG0357	Ribosomal RNA small subunit methyltransferase G
CYPRO_RS00955	COG2259	Doxx family
CYPRO_RS00960	COG1115	amino acid carrier protein
CYPRO_RS00970	COG5002	protein histidine kinase activity
CYPRO_RS00975	COG2813	Specifically methylates the guanine in position
CYPRO_RS00980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYPRO_RS00990	COG1490	D-aminoacyl-tRNA deacylase activity
CYPRO_RS01025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYPRO_RS01030	COG0537	adenosine 5'-monophosphoramidase activity
CYPRO_RS01040	COG0616	signal peptide processing
CYPRO_RS01060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYPRO_RS01080	COG1193	negative regulation of DNA recombination
CYPRO_RS01115	COG4372	Transposase
CYPRO_RS01125	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CYPRO_RS01130	COG4771	TonB-dependent receptor
CYPRO_RS01170	COG0501	Belongs to the peptidase M48B family
CYPRO_RS01175	COG0077	Prephenate dehydratase
CYPRO_RS01175	COG1605	Chorismate mutase
CYPRO_RS01180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYPRO_RS01190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CYPRO_RS01200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYPRO_RS01205	COG0552	protein localization to endoplasmic reticulum
CYPRO_RS01230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYPRO_RS01235	COG2207	Transcriptional regulator
CYPRO_RS01240	COG2217	Heavy metal translocating P-type atpase
CYPRO_RS01270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYPRO_RS01275	COG2183	response to ionizing radiation
CYPRO_RS01300	COG3590	peptidase
CYPRO_RS01315	COG0346	lactoylglutathione lyase activity
CYPRO_RS01320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYPRO_RS01320	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYPRO_RS01375	COG1373	ATPase (AAA superfamily
CYPRO_RS01390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYPRO_RS01395	COG0513	Belongs to the DEAD box helicase family
CYPRO_RS01410	COG1959	2 iron, 2 sulfur cluster binding
CYPRO_RS01415	COG0471	metal ion transport
CYPRO_RS01440	COG2205	protein histidine kinase activity
CYPRO_RS01440	COG0784	Response regulator, receiver
CYPRO_RS01465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYPRO_RS01485	COG0534	Mate efflux family protein
CYPRO_RS01495	COG1426	Protein conserved in bacteria
CYPRO_RS01505	COG0500	methyltransferase
CYPRO_RS01520	COG0742	ribosomal rna small subunit methyltransferase
CYPRO_RS01525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CYPRO_RS01530	COG0436	Aminotransferase
CYPRO_RS01555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYPRO_RS01560	COG0321	lipoyl(octanoyl) transferase activity
CYPRO_RS01565	COG0686	Belongs to the AlaDH PNT family
CYPRO_RS01575	COG0792	nuclease activity
CYPRO_RS01580	COG0506	proline dehydrogenase activity
CYPRO_RS01600	COG3568	Endonuclease Exonuclease Phosphatase
CYPRO_RS01600	COG1555	photosystem II stabilization
CYPRO_RS01620	COG2095	MarC family integral membrane protein
CYPRO_RS01640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CYPRO_RS01650	COG1446	asparaginase
CYPRO_RS01665	COG1575	Belongs to the MenA family. Type 1 subfamily
CYPRO_RS01680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYPRO_RS01685	COG1253	flavin adenine dinucleotide binding
CYPRO_RS01690	COG0629	single-stranded DNA binding
CYPRO_RS01695	COG0640	Transcriptional regulator
CYPRO_RS01705	COG1754	DNA topoisomerase type I activity
CYPRO_RS01705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYPRO_RS01715	COG2153	protein acetylation
CYPRO_RS01725	COG1555	photosystem II stabilization
CYPRO_RS01730	COG2204	response regulator
CYPRO_RS01735	COG3963	phosphatidate phosphatase activity
CYPRO_RS01745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYPRO_RS01750	COG0708	Exodeoxyribonuclease III
CYPRO_RS01755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYPRO_RS01770	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYPRO_RS01775	COG0527	aspartate kinase activity
CYPRO_RS01780	COG1473	amidohydrolase
CYPRO_RS01785	COG0316	Belongs to the HesB IscA family
CYPRO_RS01795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYPRO_RS01800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CYPRO_RS01815	COG0668	transmembrane transport
CYPRO_RS01835	COG1288	antiporter activity
CYPRO_RS01845	COG0647	UMP catabolic process
CYPRO_RS01860	COG1505	serine-type exopeptidase activity
CYPRO_RS01865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYPRO_RS01870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYPRO_RS01885	COG1410	methionine synthase
CYPRO_RS01885	COG0646	methionine synthase
CYPRO_RS01890	COG0070	glutamate synthase
CYPRO_RS01890	COG0067	glutamate synthase
CYPRO_RS01890	COG0069	glutamate synthase activity
CYPRO_RS01895	COG0493	'glutamate synthase
CYPRO_RS01905	COG0791	NLP P60 protein
CYPRO_RS01910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CYPRO_RS01915	COG1395	domain, Protein
CYPRO_RS01930	COG3011	Protein conserved in bacteria
CYPRO_RS01935	COG0423	glycine-tRNA ligase activity
CYPRO_RS01940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYPRO_RS01970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CYPRO_RS01970	COG0116	Belongs to the methyltransferase superfamily
CYPRO_RS01975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYPRO_RS01975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYPRO_RS02010	COG1012	belongs to the aldehyde dehydrogenase family
CYPRO_RS02015	COG2996	Protein conserved in bacteria
CYPRO_RS02030	COG0628	permease
CYPRO_RS02035	COG0784	Response regulator, receiver
CYPRO_RS02040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYPRO_RS02090	COG1024	Enoyl-CoA hydratase
CYPRO_RS02090	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYPRO_RS02145	COG3118	belongs to the thioredoxin family
CYPRO_RS02155	COG0577	efflux transmembrane transporter activity
CYPRO_RS02160	COG1136	(ABC) transporter
CYPRO_RS02160	COG0577	efflux transmembrane transporter activity
CYPRO_RS02165	COG1566	PFAM secretion protein HlyD family protein
CYPRO_RS02170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CYPRO_RS02185	COG3292	Two component regulator propeller
CYPRO_RS02185	COG0745	RESPONSE REGULATOR receiver
CYPRO_RS02185	COG2205	protein histidine kinase activity
CYPRO_RS02190	COG0154	amidase activity
CYPRO_RS02220	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS02225	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS02255	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CYPRO_RS02260	COG3604	Transcriptional regulator
CYPRO_RS02270	COG1222	aaa ATPase
CYPRO_RS02280	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CYPRO_RS02290	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CYPRO_RS02305	COG2827	Endonuclease containing a URI domain
CYPRO_RS02380	COG1501	Belongs to the glycosyl hydrolase 31 family
CYPRO_RS02450	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CYPRO_RS02525	COG5002	protein histidine kinase activity
CYPRO_RS02535	COG0187	DNA topoisomerase II activity
CYPRO_RS02540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYPRO_RS02565	COG0783	Belongs to the Dps family
CYPRO_RS02570	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CYPRO_RS02570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYPRO_RS02580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CYPRO_RS02590	COG3264	Mechanosensitive ion channel
CYPRO_RS02590	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYPRO_RS02595	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CYPRO_RS02605	COG0477	Major facilitator Superfamily
CYPRO_RS02620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYPRO_RS02625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYPRO_RS02630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CYPRO_RS02635	COG3657	addiction module killer protein
CYPRO_RS02645	COG1288	antiporter activity
CYPRO_RS02660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYPRO_RS02680	COG0667	Aldo Keto reductase
CYPRO_RS02695	COG1770	oligopeptidase
CYPRO_RS02720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYPRO_RS02725	COG0517	IMP dehydrogenase activity
CYPRO_RS02790	COG1796	DNA polymerase
CYPRO_RS02790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CYPRO_RS02815	COG0346	lactoylglutathione lyase activity
CYPRO_RS02835	COG1131	(ABC) transporter
CYPRO_RS02840	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CYPRO_RS02850	COG0556	nucleotide-excision repair
CYPRO_RS02870	COG4974	Belongs to the 'phage' integrase family
CYPRO_RS02885	COG4974	Belongs to the 'phage' integrase family
CYPRO_RS02950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CYPRO_RS02960	COG5002	protein histidine kinase activity
CYPRO_RS02970	COG1366	Belongs to the anti-sigma-factor antagonist family
CYPRO_RS02980	COG0784	Response regulator, receiver
CYPRO_RS02980	COG2205	protein histidine kinase activity
CYPRO_RS02980	COG5002	protein histidine kinase activity
CYPRO_RS02985	COG0745	RESPONSE REGULATOR receiver
CYPRO_RS02990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYPRO_RS03010	COG1506	peptidase
CYPRO_RS03010	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS03020	COG4242	Belongs to the peptidase S51 family
CYPRO_RS03025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYPRO_RS03030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CYPRO_RS03040	COG1196	nuclear chromosome segregation
CYPRO_RS03050	COG0802	atpase or kinase
CYPRO_RS03055	COG2212	antiporter activity
CYPRO_RS03060	COG1320	monovalent cation:proton antiporter activity
CYPRO_RS03065	COG2111	Na H antiporter
CYPRO_RS03065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYPRO_RS03070	COG2111	Na H antiporter
CYPRO_RS03075	COG1006	Multisubunit Na H antiporter MnhC subunit
CYPRO_RS03080	COG0651	ATP synthesis coupled electron transport
CYPRO_RS03085	COG1863	multisubunit Na H antiporter MnhE subunit
CYPRO_RS03090	COG2814	Major facilitator Superfamily
CYPRO_RS03095	COG1862	Preprotein translocase
CYPRO_RS03100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYPRO_RS03100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYPRO_RS03110	COG2172	sigma factor antagonist activity
CYPRO_RS03115	COG2208	phosphoserine phosphatase activity
CYPRO_RS03120	COG0277	FAD linked oxidase domain protein
CYPRO_RS03125	COG0724	RNA recognition motif
CYPRO_RS03145	COG0653	protein targeting
CYPRO_RS03150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CYPRO_RS03155	COG0594	ribonuclease P activity
CYPRO_RS03160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYPRO_RS03165	COG0706	membrane insertase activity
CYPRO_RS03190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CYPRO_RS03200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYPRO_RS03205	COG0006	proline dipeptidase activity
CYPRO_RS03270	COG0631	protein serine/threonine phosphatase activity
CYPRO_RS03295	COG0747	negative chemotaxis
CYPRO_RS03310	COG0444	Belongs to the ABC transporter superfamily
CYPRO_RS03315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CYPRO_RS03400	COG0210	DNA helicase
CYPRO_RS03445	COG3023	N-Acetylmuramoyl-L-alanine amidase
CYPRO_RS03475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CYPRO_RS03495	COG1024	Enoyl-CoA hydratase
CYPRO_RS03500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CYPRO_RS03510	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYPRO_RS03515	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CYPRO_RS03550	COG1475	DNA binding
CYPRO_RS03555	COG1192	Involved in chromosome partitioning
CYPRO_RS03570	COG0322	excinuclease ABC activity
CYPRO_RS03580	COG0658	competence protein
CYPRO_RS03580	COG2333	competence protein COMEC
CYPRO_RS03600	COG0405	Gamma-glutamyltransferase
CYPRO_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
CYPRO_RS03615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYPRO_RS03630	COG2030	dehydratase
CYPRO_RS03645	COG2267	carboxylic ester hydrolase activity
CYPRO_RS03675	COG0442	prolyl-tRNA aminoacylation
CYPRO_RS03680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYPRO_RS03695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CYPRO_RS03695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CYPRO_RS03705	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CYPRO_RS03725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CYPRO_RS03735	COG1278	Cold shock
CYPRO_RS03745	COG1595	DNA-templated transcription, initiation
CYPRO_RS03760	COG1187	pseudouridine synthase activity
CYPRO_RS03765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYPRO_RS03790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYPRO_RS03800	COG1595	DNA-templated transcription, initiation
CYPRO_RS03810	COG0393	Putative heavy-metal-binding
CYPRO_RS03820	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CYPRO_RS03845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYPRO_RS03855	COG0045	succinate-CoA ligase (ADP-forming) activity
CYPRO_RS03865	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CYPRO_RS03975	COG1217	gtp-binding protein TYPA
CYPRO_RS03980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CYPRO_RS03985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CYPRO_RS03990	COG0049	tRNA binding
CYPRO_RS03995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYPRO_RS04005	COG0051	transcription antitermination factor activity, RNA binding
CYPRO_RS04010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYPRO_RS04015	COG0088	Forms part of the polypeptide exit tunnel
CYPRO_RS04020	COG0089	rRNA binding
CYPRO_RS04025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYPRO_RS04030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYPRO_RS04040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYPRO_RS04045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CYPRO_RS04050	COG0255	Belongs to the universal ribosomal protein uL29 family
CYPRO_RS04055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYPRO_RS04060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CYPRO_RS04070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYPRO_RS04075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYPRO_RS04080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYPRO_RS04085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CYPRO_RS04090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYPRO_RS04095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYPRO_RS04100	COG0200	Binds to the 23S rRNA
CYPRO_RS04110	COG0024	Methionine aminopeptidase
CYPRO_RS04120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYPRO_RS04125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CYPRO_RS04130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYPRO_RS04135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYPRO_RS04140	COG0202	RNA polymerase activity
CYPRO_RS04145	COG0203	ribosomal protein L17
CYPRO_RS04150	COG1231	oxidoreductase activity
CYPRO_RS04175	COG2133	pyrroloquinoline quinone binding
CYPRO_RS04225	COG1397	ADP-ribosylglycohydrolase
CYPRO_RS04230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYPRO_RS04260	COG1024	Enoyl-CoA hydratase
CYPRO_RS04290	COG1045	serine acetyltransferase
CYPRO_RS04300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CYPRO_RS04305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYPRO_RS04310	COG1702	phosphate starvation-inducible protein PhoH
CYPRO_RS04315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYPRO_RS04355	COG0183	Belongs to the thiolase family
CYPRO_RS04365	COG0626	cystathionine gamma-synthase activity
CYPRO_RS04385	COG0251	oxidation-reduction process
CYPRO_RS04395	COG0179	Fumarylacetoacetate (FAA) hydrolase
CYPRO_RS04400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CYPRO_RS04405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYPRO_RS04420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CYPRO_RS04425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYPRO_RS04440	COG1739	Uncharacterized protein family UPF0029
CYPRO_RS04450	COG1053	succinate dehydrogenase
CYPRO_RS04455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CYPRO_RS04495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYPRO_RS04510	COG1506	peptidase
CYPRO_RS04510	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS04515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYPRO_RS04530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CYPRO_RS04535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CYPRO_RS04545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYPRO_RS04550	COG1640	4-alpha-glucanotransferase
CYPRO_RS04555	COG0297	glycogen (starch) synthase activity
CYPRO_RS04575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CYPRO_RS04580	COG1137	ATPase activity
CYPRO_RS04590	COG0047	phosphoribosylformylglycinamidine synthase activity
CYPRO_RS04595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYPRO_RS04600	COG4771	TonB-dependent receptor
CYPRO_RS04610	COG0803	Belongs to the bacterial solute-binding protein 9 family
CYPRO_RS04615	COG1121	(ABC) transporter
CYPRO_RS04620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYPRO_RS04620	COG1321	iron dependent repressor
CYPRO_RS04625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYPRO_RS04630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYPRO_RS04635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYPRO_RS04645	COG4771	TonB-dependent receptor
CYPRO_RS04665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CYPRO_RS04670	COG1283	sodium-dependent phosphate transmembrane transporter activity
CYPRO_RS04695	COG2094	Belongs to the DNA glycosylase MPG family
CYPRO_RS04715	COG3457	Alanine racemase
CYPRO_RS04725	COG1473	amidohydrolase
CYPRO_RS04725	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CYPRO_RS04730	COG1629	transport
CYPRO_RS04785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYPRO_RS04790	COG4191	Histidine kinase
CYPRO_RS04800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYPRO_RS04815	COG2133	pyrroloquinoline quinone binding
CYPRO_RS04825	COG0259	pyridoxamine-phosphate oxidase activity
CYPRO_RS04860	COG0095	Lipoate-protein ligase
CYPRO_RS04885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CYPRO_RS04900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYPRO_RS04930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYPRO_RS04945	COG0534	Mate efflux family protein
CYPRO_RS04950	COG5000	phosphorelay sensor kinase activity
CYPRO_RS04955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYPRO_RS04960	COG0799	negative regulation of ribosome biogenesis
CYPRO_RS04975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYPRO_RS04980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYPRO_RS04980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYPRO_RS05035	COG0081	regulation of translation
CYPRO_RS05040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYPRO_RS05045	COG0222	ribosome binding
CYPRO_RS05050	COG0085	RNA polymerase activity
CYPRO_RS05055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYPRO_RS05060	COG5002	protein histidine kinase activity
CYPRO_RS05060	COG2205	protein histidine kinase activity
CYPRO_RS05060	COG0784	Response regulator, receiver
CYPRO_RS05075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYPRO_RS05080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYPRO_RS05100	COG3279	Response regulator of the LytR AlgR family
CYPRO_RS05110	COG0784	Response regulator, receiver
CYPRO_RS05110	COG2198	Histidine kinase
CYPRO_RS05110	COG5002	protein histidine kinase activity
CYPRO_RS05125	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS05150	COG1216	Glycosyl transferase, family 2
CYPRO_RS05170	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS05190	COG1366	Belongs to the anti-sigma-factor antagonist family
CYPRO_RS05255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CYPRO_RS05270	COG0300	oxidoreductase activity
CYPRO_RS05275	COG3186	Phenylalanine-4-hydroxylase
CYPRO_RS05280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYPRO_RS05290	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYPRO_RS05300	COG0745	RESPONSE REGULATOR receiver
CYPRO_RS05310	COG0592	DNA-directed DNA polymerase activity
CYPRO_RS05315	COG2001	Belongs to the MraZ family
CYPRO_RS05320	COG0275	rRNA processing
CYPRO_RS05330	COG0768	penicillin binding
CYPRO_RS05335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CYPRO_RS05340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYPRO_RS05345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYPRO_RS05350	COG0772	Belongs to the SEDS family
CYPRO_RS05355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYPRO_RS05360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYPRO_RS05375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYPRO_RS05380	COG0671	phosphoesterase, PA-phosphatase related
CYPRO_RS05415	COG0668	transmembrane transport
CYPRO_RS05440	COG0569	domain protein
CYPRO_RS05450	COG0126	phosphoglycerate kinase activity
CYPRO_RS05465	COG0105	UTP biosynthetic process
CYPRO_RS05470	COG3876	Protein conserved in bacteria
CYPRO_RS05475	COG1132	(ABC) transporter
CYPRO_RS05605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CYPRO_RS05640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CYPRO_RS05660	COG3695	enzyme binding
CYPRO_RS05685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYPRO_RS05700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYPRO_RS05705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYPRO_RS05710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYPRO_RS05715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYPRO_RS05725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CYPRO_RS05730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CYPRO_RS05735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYPRO_RS05770	COG0494	nUDIX hydrolase
CYPRO_RS05780	COG2192	nodulation
CYPRO_RS05785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYPRO_RS05795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYPRO_RS05795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYPRO_RS05800	COG1523	belongs to the glycosyl hydrolase 13 family
CYPRO_RS05810	COG0733	neurotransmitter:sodium symporter activity
CYPRO_RS05815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYPRO_RS05825	COG0439	Biotin carboxylase
CYPRO_RS05830	COG0509	glycine decarboxylation via glycine cleavage system
CYPRO_RS05835	COG0519	Catalyzes the synthesis of GMP from XMP
CYPRO_RS05835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYPRO_RS05870	COG1850	ribulose-bisphosphate carboxylase activity
CYPRO_RS05875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CYPRO_RS05880	COG1366	Belongs to the anti-sigma-factor antagonist family
CYPRO_RS05885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYPRO_RS05890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYPRO_RS05935	COG4152	abc transporter atp-binding protein
CYPRO_RS05940	COG0297	glycogen (starch) synthase activity
CYPRO_RS05945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYPRO_RS05950	COG1752	Esterase of the alpha-beta hydrolase superfamily
CYPRO_RS05960	COG0475	glutathione-regulated potassium exporter activity
CYPRO_RS05960	COG0589	response to stress
CYPRO_RS05965	COG0516	GMP reductase activity
CYPRO_RS05965	COG0517	IMP dehydrogenase activity
CYPRO_RS05995	COG0356	it plays a direct role in the translocation of protons across the membrane
CYPRO_RS06000	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYPRO_RS06005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYPRO_RS06010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYPRO_RS06015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYPRO_RS06020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYPRO_RS06055	COG3152	Membrane
CYPRO_RS06060	COG4206	TonB-dependent receptor
CYPRO_RS06065	COG1506	peptidase
CYPRO_RS06065	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS06075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYPRO_RS06115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYPRO_RS06135	COG2197	response regulator
CYPRO_RS06145	COG1331	Highly conserved protein containing a thioredoxin domain
CYPRO_RS06150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYPRO_RS06155	COG0805	protein transport
CYPRO_RS06160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYPRO_RS06175	COG0366	Alpha amylase catalytic
CYPRO_RS06200	COG3530	Putative quorum-sensing-regulated virulence factor
CYPRO_RS06240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYPRO_RS06255	COG0463	Glycosyl transferase, family 2
CYPRO_RS06265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYPRO_RS06270	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CYPRO_RS06285	COG4771	TonB-dependent receptor
CYPRO_RS06300	COG0483	inositol monophosphate 1-phosphatase activity
CYPRO_RS06305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CYPRO_RS06330	COG1136	(ABC) transporter
CYPRO_RS06335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYPRO_RS06340	COG1496	oxidoreductase activity
CYPRO_RS06345	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYPRO_RS06370	COG1201	RNA secondary structure unwinding
CYPRO_RS06375	COG1012	belongs to the aldehyde dehydrogenase family
CYPRO_RS06380	COG0205	6-phosphofructokinase activity
CYPRO_RS06385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYPRO_RS06405	COG1012	belongs to the aldehyde dehydrogenase family
CYPRO_RS06425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CYPRO_RS06450	COG3292	Two component regulator propeller
CYPRO_RS06450	COG0745	RESPONSE REGULATOR receiver
CYPRO_RS06450	COG2205	protein histidine kinase activity
CYPRO_RS06490	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYPRO_RS06495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYPRO_RS06500	COG0429	hydrolase of the alpha beta-hydrolase fold
CYPRO_RS06525	COG0596	Alpha beta hydrolase
CYPRO_RS06545	COG0084	hydrolase, TatD family'
CYPRO_RS06575	COG0326	Molecular chaperone. Has ATPase activity
CYPRO_RS06645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYPRO_RS06650	COG2045	Belongs to the ComB family
CYPRO_RS06655	COG1674	ftsk spoiiie
CYPRO_RS06680	COG0811	peptide transport
CYPRO_RS06700	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CYPRO_RS06730	COG1404	Belongs to the peptidase S8 family
CYPRO_RS06745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYPRO_RS06770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYPRO_RS06775	COG0137	argininosuccinate synthase activity
CYPRO_RS06780	COG0165	Argininosuccinate lyase
CYPRO_RS06785	COG1373	ATPase (AAA superfamily
CYPRO_RS06790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CYPRO_RS06810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CYPRO_RS06820	COG1047	Peptidyl-prolyl cis-trans
CYPRO_RS06840	COG0167	dihydroorotate dehydrogenase activity
CYPRO_RS06845	COG0285	dihydrofolate synthase activity
CYPRO_RS06850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CYPRO_RS06860	COG0616	signal peptide processing
CYPRO_RS06875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYPRO_RS06880	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS06925	COG4372	Transposase
CYPRO_RS06930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CYPRO_RS06955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CYPRO_RS06960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYPRO_RS06965	COG0114	fumarate hydratase activity
CYPRO_RS06970	COG1785	Belongs to the alkaline phosphatase family
CYPRO_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
CYPRO_RS06985	COG1073	alpha beta
CYPRO_RS07000	COG1254	Belongs to the acylphosphatase family
CYPRO_RS07020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYPRO_RS07030	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CYPRO_RS07030	COG1793	dna ligase
CYPRO_RS07060	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CYPRO_RS07075	COG3459	Glycosyltransferase 36 associated
CYPRO_RS07100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CYPRO_RS07235	COG2204	response regulator
CYPRO_RS07240	COG4191	Histidine kinase
CYPRO_RS07255	COG2954	triphosphatase activity
CYPRO_RS07265	COG1392	Phosphate transport regulator
CYPRO_RS07315	COG2211	Major facilitator Superfamily
CYPRO_RS07335	COG2814	Major facilitator Superfamily
CYPRO_RS07340	COG1472	Belongs to the glycosyl hydrolase 3 family
CYPRO_RS07355	COG2201	protein-glutamate methylesterase activity
CYPRO_RS07360	COG2205	protein histidine kinase activity
CYPRO_RS07360	COG0784	Response regulator, receiver
CYPRO_RS07365	COG1472	Belongs to the glycosyl hydrolase 3 family
CYPRO_RS07380	COG3428	Bacterial PH domain
CYPRO_RS07385	COG3402	PFAM membrane-flanked domain
CYPRO_RS07395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYPRO_RS07425	COG4864	UPF0365 protein
CYPRO_RS07430	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CYPRO_RS07440	COG1979	alcohol dehydrogenase
CYPRO_RS07445	COG1473	amidohydrolase
CYPRO_RS07470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYPRO_RS07485	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CYPRO_RS07500	COG0693	protein deglycase activity
CYPRO_RS07535	COG0343	queuine tRNA-ribosyltransferase activity
CYPRO_RS07540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYPRO_RS07545	COG0463	Glycosyl transferase, family 2
CYPRO_RS07550	COG0825	malonyl-CoA metabolic process
CYPRO_RS07585	COG4589	Belongs to the CDS family
CYPRO_RS07590	COG1090	epimerase
CYPRO_RS07610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYPRO_RS07625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYPRO_RS07630	COG0071	Belongs to the small heat shock protein (HSP20) family
CYPRO_RS07635	COG0443	Heat shock 70 kDa protein
CYPRO_RS07645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYPRO_RS07685	COG0484	heat shock protein binding
CYPRO_RS07695	COG0473	3-isopropylmalate dehydrogenase activity
CYPRO_RS07700	COG1216	Glycosyl transferase, family 2
CYPRO_RS07710	COG0037	tRNA processing
CYPRO_RS07710	COG0590	tRNA wobble adenosine to inosine editing
CYPRO_RS07725	COG2234	aminopeptidase activity
CYPRO_RS07725	COG4935	Belongs to the peptidase S8 family
CYPRO_RS07730	COG0686	Belongs to the AlaDH PNT family
CYPRO_RS07735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYPRO_RS07745	COG2311	Membrane
CYPRO_RS07750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYPRO_RS07755	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CYPRO_RS07770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYPRO_RS07785	COG0254	rRNA binding
CYPRO_RS07790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYPRO_RS07810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYPRO_RS07845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CYPRO_RS07850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYPRO_RS07855	COG1058	Belongs to the CinA family
CYPRO_RS07855	COG1546	Belongs to the CinA family
CYPRO_RS07875	COG1132	(ABC) transporter
CYPRO_RS07905	COG0280	phosphate acetyltransferase
CYPRO_RS07915	COG2205	protein histidine kinase activity
CYPRO_RS07915	COG3437	response regulator, receiver
CYPRO_RS07915	COG3850	Histidine kinase
CYPRO_RS07915	COG4999	Histidine kinase
CYPRO_RS07920	COG0719	Fe-S assembly protein
CYPRO_RS07925	COG0396	ATPase activity
CYPRO_RS07930	COG0719	Fe-S assembly protein
CYPRO_RS07935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYPRO_RS07950	COG0316	Belongs to the HesB IscA family
CYPRO_RS07960	COG1304	FMN binding
CYPRO_RS07965	COG0142	geranyltranstransferase activity
CYPRO_RS07975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYPRO_RS07980	COG0590	tRNA wobble adenosine to inosine editing
CYPRO_RS07985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CYPRO_RS08010	COG0745	RESPONSE REGULATOR receiver
CYPRO_RS08025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYPRO_RS08035	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CYPRO_RS08040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYPRO_RS08045	COG0758	DNA mediated transformation
CYPRO_RS08050	COG2172	sigma factor antagonist activity
CYPRO_RS08055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYPRO_RS08060	COG0791	NLP P60 protein
CYPRO_RS08070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYPRO_RS08075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYPRO_RS08080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYPRO_RS08090	COG0248	Ppx GppA phosphatase
CYPRO_RS08095	COG2814	Major facilitator Superfamily
CYPRO_RS08105	COG2379	hydroxypyruvate reductase
CYPRO_RS08120	COG0714	Associated with various cellular activities
CYPRO_RS08125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYPRO_RS08135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYPRO_RS08140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CYPRO_RS08155	COG0662	Cupin 2, conserved barrel domain protein
CYPRO_RS08155	COG2207	Transcriptional regulator
CYPRO_RS08165	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CYPRO_RS08175	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CYPRO_RS08235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYPRO_RS08265	COG1024	Enoyl-CoA hydratase
CYPRO_RS08280	COG2264	protein methyltransferase activity
CYPRO_RS08285	COG0009	L-threonylcarbamoyladenylate synthase
CYPRO_RS08310	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CYPRO_RS08325	COG1169	isochorismate synthase
CYPRO_RS08345	COG0577	efflux transmembrane transporter activity
CYPRO_RS08350	COG1136	(ABC) transporter
CYPRO_RS08360	COG0779	Required for maturation of 30S ribosomal subunits
CYPRO_RS08365	COG0195	Participates in both transcription termination and antitermination
CYPRO_RS08370	COG5180	pathogenesis
CYPRO_RS08370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYPRO_RS08370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYPRO_RS08370	COG5180	pathogenesis
CYPRO_RS08375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYPRO_RS08380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYPRO_RS08385	COG0196	riboflavin kinase activity
CYPRO_RS08390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYPRO_RS08395	COG1185	polyribonucleotide nucleotidyltransferase activity
CYPRO_RS08400	COG0612	Peptidase, M16
CYPRO_RS08405	COG0017	Asparaginyl-tRNA synthetase
CYPRO_RS08415	COG1595	DNA-templated transcription, initiation
CYPRO_RS08430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYPRO_RS08435	COG1115	amino acid carrier protein
CYPRO_RS08440	COG0776	regulation of translation
CYPRO_RS08460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYPRO_RS08465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYPRO_RS08475	COG0557	exoribonuclease II activity
CYPRO_RS08515	COG0604	alcohol dehydrogenase
CYPRO_RS08525	COG0564	pseudouridine synthase activity
CYPRO_RS08530	COG3850	Histidine kinase
CYPRO_RS08530	COG4999	Histidine kinase
CYPRO_RS08530	COG3437	response regulator, receiver
CYPRO_RS08530	COG2205	protein histidine kinase activity
CYPRO_RS08540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYPRO_RS08545	COG0215	cysteine-tRNA ligase activity
CYPRO_RS08570	COG1570	exodeoxyribonuclease VII activity
CYPRO_RS08575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYPRO_RS08590	COG2205	protein histidine kinase activity
CYPRO_RS08600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYPRO_RS08605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CYPRO_RS08635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYPRO_RS08635	COG0140	phosphoribosyl-ATP diphosphatase activity
CYPRO_RS08640	COG0107	imidazoleglycerol-phosphate synthase activity
CYPRO_RS08645	COG2304	oxidoreductase activity
CYPRO_RS08660	COG0686	Belongs to the AlaDH PNT family
CYPRO_RS08670	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS08700	COG1136	(ABC) transporter
CYPRO_RS08705	COG1692	metallophosphoesterase
CYPRO_RS08720	COG0072	phenylalanine-tRNA ligase activity
CYPRO_RS08720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYPRO_RS08725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYPRO_RS08730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CYPRO_RS08735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CYPRO_RS08740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYPRO_RS08745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYPRO_RS08760	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CYPRO_RS08765	COG1132	(ABC) transporter
CYPRO_RS08770	COG1234	tRNA 3'-trailer cleavage
CYPRO_RS08775	COG1132	(ABC) transporter
CYPRO_RS08780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYPRO_RS08785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYPRO_RS08790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CYPRO_RS08795	COG0022	dehydrogenase e1 component
CYPRO_RS08800	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYPRO_RS08815	COG1088	dTDP-glucose 4,6-dehydratase activity
CYPRO_RS08830	COG2205	protein histidine kinase activity
CYPRO_RS08830	COG0784	Response regulator, receiver
CYPRO_RS08835	COG3437	response regulator, receiver
CYPRO_RS08845	COG0735	belongs to the Fur family
CYPRO_RS08855	COG0180	Tryptophanyl-tRNA synthetase
CYPRO_RS08860	COG0512	Glutamine amidotransferase of anthranilate synthase
CYPRO_RS08860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYPRO_RS08865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYPRO_RS08870	COG0134	indole-3-glycerol-phosphate synthase activity
CYPRO_RS08875	COG0135	phosphoribosylanthranilate isomerase activity
CYPRO_RS08880	COG0482	sulfurtransferase activity
CYPRO_RS08900	COG0737	Belongs to the 5'-nucleotidase family
CYPRO_RS08905	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYPRO_RS08910	COG0750	zinc metalloprotease
CYPRO_RS08915	COG0688	phosphatidylethanolamine metabolic process
CYPRO_RS08920	COG1183	phosphatidylcholine synthase activity
CYPRO_RS08930	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CYPRO_RS08940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYPRO_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
CYPRO_RS08960	COG0602	queuosine metabolic process
CYPRO_RS08965	COG0720	synthase
CYPRO_RS08980	COG0733	neurotransmitter:sodium symporter activity
CYPRO_RS09000	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYPRO_RS09015	COG4399	Belongs to the UPF0754 family
CYPRO_RS09030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CYPRO_RS09045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CYPRO_RS09050	COG0778	Nitroreductase
CYPRO_RS09085	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYPRO_RS09085	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYPRO_RS09085	COG1703	isobutyryl-CoA mutase activity
CYPRO_RS09100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CYPRO_RS09105	COG1335	isochorismatase
CYPRO_RS09130	COG1595	DNA-templated transcription, initiation
CYPRO_RS09135	COG0488	(ABC) transporter
CYPRO_RS09145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYPRO_RS09160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYPRO_RS09165	COG1381	Involved in DNA repair and RecF pathway recombination
CYPRO_RS09170	COG2409	Drug exporters of the RND superfamily
CYPRO_RS09175	COG0358	DNA primase activity
CYPRO_RS09185	COG1295	ribonuclease BN
CYPRO_RS09195	COG0259	pyridoxamine-phosphate oxidase activity
CYPRO_RS09200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYPRO_RS09205	COG1830	Aldolase
CYPRO_RS09220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYPRO_RS09225	COG1968	undecaprenyl-diphosphatase activity
CYPRO_RS09240	COG0159	tryptophan synthase activity
CYPRO_RS09245	COG0133	tryptophan synthase activity
CYPRO_RS09255	COG0436	Aminotransferase
CYPRO_RS09280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYPRO_RS09285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYPRO_RS09290	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYPRO_RS09295	COG0649	NAD binding
CYPRO_RS09325	COG0189	ligase activity
CYPRO_RS09335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYPRO_RS09350	COG4221	oxidoreductase activity
CYPRO_RS09355	COG0259	pyridoxamine-phosphate oxidase activity
CYPRO_RS09360	COG0033	Phosphoglucomutase
CYPRO_RS09370	COG1114	Component of the transport system for branched-chain amino acids
CYPRO_RS09375	COG3447	MASE1 domain protein
CYPRO_RS09375	COG5001	Diguanylate cyclase
CYPRO_RS09375	COG5002	protein histidine kinase activity
CYPRO_RS09380	COG4251	negative regulation of phosphorylation
CYPRO_RS09385	COG2201	protein-glutamate methylesterase activity
CYPRO_RS09395	COG0840	transmembrane signaling receptor activity
CYPRO_RS09430	COG1228	amidohydrolase
CYPRO_RS09485	COG2205	protein histidine kinase activity
CYPRO_RS09485	COG3292	Two component regulator propeller
CYPRO_RS09485	COG0745	RESPONSE REGULATOR receiver
CYPRO_RS09495	COG2188	Transcriptional regulator
CYPRO_RS09520	COG0471	metal ion transport
CYPRO_RS09520	COG3273	potassium ion transport
CYPRO_RS09525	COG1054	Belongs to the UPF0176 family
CYPRO_RS09585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYPRO_RS09620	COG1309	transcriptional regulator
CYPRO_RS09635	COG1442	glycosyl transferase family 8
CYPRO_RS09635	COG1216	Glycosyl transferase, family 2
CYPRO_RS09640	COG4974	Belongs to the 'phage' integrase family
CYPRO_RS09650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CYPRO_RS09655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYPRO_RS09660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CYPRO_RS09670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYPRO_RS09675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CYPRO_RS09680	COG1228	amidohydrolase
CYPRO_RS09700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CYPRO_RS09705	COG0527	aspartate kinase activity
CYPRO_RS09705	COG0460	homoserine dehydrogenase
CYPRO_RS09710	COG0083	homoserine kinase activity
CYPRO_RS09715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYPRO_RS09720	COG1505	serine-type exopeptidase activity
CYPRO_RS09735	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CYPRO_RS09745	COG0514	ATP-dependent DNA helicase (RecQ)
CYPRO_RS09750	COG0784	Response regulator, receiver
CYPRO_RS09750	COG2205	protein histidine kinase activity
CYPRO_RS09760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYPRO_RS09765	COG0484	heat shock protein binding
CYPRO_RS09770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYPRO_RS09785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CYPRO_RS09815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYPRO_RS09820	COG1111	helicase
CYPRO_RS09820	COG1205	dead DEAH box helicase
CYPRO_RS09840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CYPRO_RS09845	COG4638	Rieske (2fe-2S)
CYPRO_RS09850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYPRO_RS09860	COG3573	Dehydrogenase
CYPRO_RS09880	COG1960	acyl-CoA dehydrogenase activity
CYPRO_RS09885	COG0183	Belongs to the thiolase family
CYPRO_RS09890	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYPRO_RS09890	COG1024	Enoyl-CoA hydratase
CYPRO_RS09905	COG1012	belongs to the aldehyde dehydrogenase family
CYPRO_RS09905	COG1454	alcohol dehydrogenase
CYPRO_RS09910	COG1454	alcohol dehydrogenase
CYPRO_RS09930	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYPRO_RS09935	COG0019	diaminopimelate decarboxylase activity
CYPRO_RS09950	COG1472	Belongs to the glycosyl hydrolase 3 family
CYPRO_RS09970	COG0737	Belongs to the 5'-nucleotidase family
CYPRO_RS09990	COG0384	phenazine biosynthesis protein PhzF
CYPRO_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
CYPRO_RS10000	COG1022	Amp-dependent synthetase and ligase
CYPRO_RS10005	COG2050	protein possibly involved in aromatic compounds catabolism
CYPRO_RS10020	COG1078	dGTPase activity
CYPRO_RS10040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CYPRO_RS10045	COG0463	Glycosyl transferase, family 2
CYPRO_RS10065	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CYPRO_RS10075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CYPRO_RS10115	COG2205	protein histidine kinase activity
CYPRO_RS10115	COG0745	RESPONSE REGULATOR receiver
CYPRO_RS10115	COG3292	Two component regulator propeller
CYPRO_RS10120	COG4372	Transposase
CYPRO_RS10155	COG0210	DNA helicase
CYPRO_RS10170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYPRO_RS10175	COG1162	GTPase activity
CYPRO_RS10185	COG0531	amino acid
CYPRO_RS10190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CYPRO_RS10195	COG1012	belongs to the aldehyde dehydrogenase family
CYPRO_RS10225	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CYPRO_RS10240	COG0732	type I restriction modification DNA specificity domain
CYPRO_RS10245	COG1943	Transposase
CYPRO_RS10270	COG4772	TonB-dependent receptor
CYPRO_RS10295	COG0300	oxidoreductase activity
CYPRO_RS10310	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS10315	COG2326	polyphosphate kinase activity
CYPRO_RS10325	COG1506	peptidase
CYPRO_RS10325	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS10330	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CYPRO_RS10335	COG4221	oxidoreductase activity
CYPRO_RS10360	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CYPRO_RS10365	COG0439	Biotin carboxylase
CYPRO_RS10375	COG1562	ergosterol biosynthetic process
CYPRO_RS10380	COG1609	Transcriptional regulator
CYPRO_RS10385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYPRO_RS10390	COG1752	Esterase of the alpha-beta hydrolase superfamily
CYPRO_RS10395	COG1666	GTP binding
CYPRO_RS10410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CYPRO_RS10425	COG0151	Belongs to the GarS family
CYPRO_RS10440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYPRO_RS10445	COG2957	Belongs to the agmatine deiminase family
CYPRO_RS10450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYPRO_RS10450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYPRO_RS10460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CYPRO_RS10510	COG0640	Transcriptional regulator
CYPRO_RS10525	COG2385	sporulation resulting in formation of a cellular spore
CYPRO_RS10535	COG0237	dephospho-CoA kinase activity
CYPRO_RS10540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CYPRO_RS10545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CYPRO_RS10555	COG0483	inositol monophosphate 1-phosphatase activity
CYPRO_RS10560	COG1573	uracil-dna glycosylase
CYPRO_RS10565	COG0305	Participates in initiation and elongation during chromosome replication
CYPRO_RS10630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYPRO_RS10635	COG2211	Major facilitator Superfamily
CYPRO_RS10640	COG0673	inositol 2-dehydrogenase activity
CYPRO_RS10655	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CYPRO_RS10660	COG1074	ATP-dependent DNA helicase activity
CYPRO_RS10665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CYPRO_RS10675	COG0514	ATP-dependent DNA helicase (RecQ)
CYPRO_RS10690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CYPRO_RS10710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CYPRO_RS10715	COG2224	Isocitrate lyase
CYPRO_RS10720	COG0012	GTP binding
CYPRO_RS10730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYPRO_RS10750	COG0339	signal peptide processing
CYPRO_RS10755	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS10755	COG1506	peptidase
CYPRO_RS10780	COG0745	RESPONSE REGULATOR receiver
CYPRO_RS10785	COG2176	DNA-directed DNA polymerase activity
CYPRO_RS10785	COG5002	protein histidine kinase activity
CYPRO_RS10900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CYPRO_RS10930	COG0322	excinuclease ABC activity
CYPRO_RS10935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYPRO_RS10940	COG4106	trans-aconitate 2-methyltransferase activity
CYPRO_RS10970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYPRO_RS10980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CYPRO_RS10985	COG2264	protein methyltransferase activity
CYPRO_RS10990	COG2884	Cell division ATP-binding protein ftsE
CYPRO_RS10995	COG0860	N-Acetylmuramoyl-L-alanine amidase
CYPRO_RS11015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYPRO_RS11020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYPRO_RS11085	COG1160	GTP binding
CYPRO_RS11110	COG0101	tRNA pseudouridine synthase activity
CYPRO_RS11120	COG1138	Cytochrome C-type biogenesis protein
CYPRO_RS11145	COG0756	dUTP diphosphatase activity
CYPRO_RS11170	COG0511	ligase activity, forming carbon-carbon bonds
CYPRO_RS11175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYPRO_RS11185	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CYPRO_RS11190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CYPRO_RS11195	COG0793	Belongs to the peptidase S41A family
CYPRO_RS11215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYPRO_RS11220	COG0488	(ABC) transporter
CYPRO_RS11235	COG1506	peptidase
CYPRO_RS11235	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS11260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CYPRO_RS11265	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYPRO_RS11280	COG0205	6-phosphofructokinase activity
CYPRO_RS11285	COG0166	Belongs to the GPI family
CYPRO_RS11290	COG1428	Deoxynucleoside kinase
CYPRO_RS11300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYPRO_RS11305	COG0416	fatty acid biosynthetic process
CYPRO_RS11310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYPRO_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
CYPRO_RS11325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYPRO_RS11330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYPRO_RS11335	COG0571	ribonuclease III activity
CYPRO_RS11340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYPRO_RS11345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CYPRO_RS11350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CYPRO_RS11360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYPRO_RS11365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CYPRO_RS11365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYPRO_RS11370	COG0525	valine-tRNA ligase activity
CYPRO_RS11380	COG1469	GTP cyclohydrolase I activity
CYPRO_RS11390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYPRO_RS11400	COG0076	glutamate decarboxylase activity
CYPRO_RS11410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CYPRO_RS11435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYPRO_RS11435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYPRO_RS11445	COG1363	Peptidase, m42
CYPRO_RS11450	COG1022	Amp-dependent synthetase and ligase
CYPRO_RS11475	COG2177	Part of the ABC transporter FtsEX involved in
CYPRO_RS11490	COG2873	o-acetylhomoserine
CYPRO_RS11495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYPRO_RS11500	COG0527	aspartate kinase activity
CYPRO_RS11500	COG0460	homoserine dehydrogenase
CYPRO_RS11545	COG4771	TonB-dependent receptor
CYPRO_RS11620	COG3118	belongs to the thioredoxin family
CYPRO_RS11630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CYPRO_RS11640	COG1522	sequence-specific DNA binding
CYPRO_RS11650	COG2020	methyltransferase activity
CYPRO_RS11665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYPRO_RS11700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CYPRO_RS11710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CYPRO_RS11710	COG0131	Imidazoleglycerol-phosphate dehydratase
CYPRO_RS11715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYPRO_RS11720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CYPRO_RS11725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CYPRO_RS11730	COG0481	GTPase activity
CYPRO_RS11750	COG0366	Alpha amylase catalytic
CYPRO_RS11755	COG0436	Aminotransferase
CYPRO_RS11760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYPRO_RS11765	COG2204	response regulator
CYPRO_RS11775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYPRO_RS11775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CYPRO_RS11775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CYPRO_RS11790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYPRO_RS11800	COG0022	dehydrogenase e1 component
CYPRO_RS11805	COG0456	acetyltransferase
CYPRO_RS11810	COG0156	8-amino-7-oxononanoate synthase activity
CYPRO_RS11825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYPRO_RS11840	COG1309	transcriptional regulator
CYPRO_RS11845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CYPRO_RS11860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYPRO_RS11885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYPRO_RS11920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYPRO_RS11925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYPRO_RS11935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYPRO_RS12025	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYPRO_RS12030	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CYPRO_RS12060	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS12160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CYPRO_RS12200	COG2244	polysaccharide biosynthetic process
CYPRO_RS12240	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS12245	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS12270	COG0469	pyruvate kinase activity
CYPRO_RS12275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYPRO_RS12290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CYPRO_RS12300	COG0489	protein tyrosine kinase activity
CYPRO_RS12310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYPRO_RS12310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYPRO_RS12325	COG0542	response to heat
CYPRO_RS12390	COG4206	TonB-dependent receptor
CYPRO_RS12390	COG1629	transport
CYPRO_RS12405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYPRO_RS12425	COG1024	Enoyl-CoA hydratase
CYPRO_RS12430	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CYPRO_RS12445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYPRO_RS12450	COG0252	asparaginase activity
CYPRO_RS12460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CYPRO_RS12465	COG2322	membrane
CYPRO_RS12470	COG0523	cobalamin synthesis protein
CYPRO_RS12475	COG5002	protein histidine kinase activity
CYPRO_RS12515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYPRO_RS12520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CYPRO_RS12530	COG0793	Belongs to the peptidase S41A family
CYPRO_RS12540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYPRO_RS12540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYPRO_RS12555	COG2816	NAD+ diphosphatase activity
CYPRO_RS12560	COG0504	CTP synthase activity
CYPRO_RS12575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYPRO_RS12580	COG0745	RESPONSE REGULATOR receiver
CYPRO_RS12585	COG5002	protein histidine kinase activity
CYPRO_RS12590	COG1131	(ABC) transporter
CYPRO_RS12600	COG1725	Transcriptional regulator
CYPRO_RS12610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYPRO_RS12615	COG0628	permease
CYPRO_RS12640	COG1234	tRNA 3'-trailer cleavage
CYPRO_RS12655	COG1404	Belongs to the peptidase S8 family
CYPRO_RS12665	COG1104	cysteine desulfurase activity
CYPRO_RS12680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CYPRO_RS12690	COG0501	Belongs to the peptidase M48B family
CYPRO_RS12695	COG1704	LemA family
CYPRO_RS12705	COG2366	antibiotic biosynthetic process
CYPRO_RS12730	COG0415	Belongs to the DNA photolyase family
CYPRO_RS12755	COG0415	Belongs to the DNA photolyase family
CYPRO_RS12765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYPRO_RS12780	COG2239	Acts as a magnesium transporter
CYPRO_RS12785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYPRO_RS12790	COG0242	peptide deformylase activity
CYPRO_RS12795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYPRO_RS12805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYPRO_RS12810	COG4953	penicillin-binding protein 1C
CYPRO_RS12820	COG2373	Large extracellular alpha-helical protein
CYPRO_RS12850	COG3483	tryptophan 2,3-dioxygenase activity
CYPRO_RS12855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYPRO_RS12860	COG2137	regulation of response to DNA damage stimulus
CYPRO_RS12865	COG0628	permease
CYPRO_RS12875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CYPRO_RS12880	COG0138	bifunctional purine biosynthesis protein purh
CYPRO_RS12900	COG0768	penicillin binding
CYPRO_RS12905	COG0772	Belongs to the SEDS family
CYPRO_RS12910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYPRO_RS12940	COG2086	electron transfer activity
CYPRO_RS12945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CYPRO_RS12950	COG0644	oxidoreductase
CYPRO_RS12965	COG2161	toxin-antitoxin pair type II binding
CYPRO_RS12975	COG0419	ATPase involved in DNA repair
CYPRO_RS12980	COG0420	3'-5' exonuclease activity
CYPRO_RS13000	COG1629	transport
CYPRO_RS13020	COG0567	Dehydrogenase, E1 component
CYPRO_RS13020	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYPRO_RS13040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYPRO_RS13055	COG0589	response to stress
CYPRO_RS13060	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYPRO_RS13070	COG0346	lactoylglutathione lyase activity
CYPRO_RS13075	COG1554	hydrolase, family 65, central catalytic
CYPRO_RS13085	COG0154	amidase activity
CYPRO_RS13090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYPRO_RS13110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYPRO_RS13115	COG1233	COG1233 Phytoene dehydrogenase and related
CYPRO_RS13120	COG0668	transmembrane transport
CYPRO_RS13140	COG0300	oxidoreductase activity
CYPRO_RS13155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYPRO_RS13160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CYPRO_RS13180	COG0811	peptide transport
CYPRO_RS13190	COG0359	binds to the 23S rRNA
CYPRO_RS13195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CYPRO_RS13200	COG0360	Binds together with S18 to 16S ribosomal RNA
CYPRO_RS13205	COG1007	ATP synthesis coupled electron transport
CYPRO_RS13210	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYPRO_RS13220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYPRO_RS13230	COG0839	Belongs to the complex I subunit 6 family
CYPRO_RS13235	COG0714	Associated with various cellular activities
CYPRO_RS13250	COG0539	negative regulation of cytoplasmic translation
CYPRO_RS13250	COG2183	response to ionizing radiation
CYPRO_RS13255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYPRO_RS13260	COG0268	Binds directly to 16S ribosomal RNA
CYPRO_RS13275	COG0542	response to heat
CYPRO_RS13285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYPRO_RS13290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYPRO_RS13295	COG4133	protoheme IX ABC transporter activity
CYPRO_RS13305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYPRO_RS13320	COG0469	pyruvate kinase activity
CYPRO_RS13330	COG1285	pathogenesis
CYPRO_RS13355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CYPRO_RS13360	COG0037	tRNA processing
CYPRO_RS13365	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CYPRO_RS13365	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CYPRO_RS13375	COG2222	sugar isomerase
CYPRO_RS13380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYPRO_RS13385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYPRO_RS13390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYPRO_RS13400	COG3850	Histidine kinase
CYPRO_RS13400	COG2205	protein histidine kinase activity
CYPRO_RS13400	COG3437	response regulator, receiver
CYPRO_RS13400	COG4999	Histidine kinase
CYPRO_RS13425	COG3391	amine dehydrogenase activity
CYPRO_RS13445	COG0469	pyruvate kinase activity
CYPRO_RS13450	COG0469	pyruvate kinase activity
CYPRO_RS13460	COG0584	glycerophosphoryl diester phosphodiesterase
CYPRO_RS13480	COG4181	ATPase activity
CYPRO_RS13490	COG0124	histidyl-tRNA synthetase
CYPRO_RS13505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYPRO_RS13510	COG0542	response to heat
CYPRO_RS13520	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS13530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYPRO_RS13535	COG0058	SHG alpha-glucan phosphorylase activity
CYPRO_RS13545	COG0179	Fumarylacetoacetate (FAA) hydrolase
CYPRO_RS13580	COG1228	amidohydrolase
CYPRO_RS13580	COG1228	amidohydrolase
CYPRO_RS13595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYPRO_RS13625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYPRO_RS13630	COG1472	Belongs to the glycosyl hydrolase 3 family
CYPRO_RS13635	COG0497	DNA recombination
CYPRO_RS13645	COG0564	pseudouridine synthase activity
CYPRO_RS13660	COG0730	response to heat
CYPRO_RS13665	COG1283	sodium-dependent phosphate transmembrane transporter activity
CYPRO_RS13675	COG1960	acyl-CoA dehydrogenase activity
CYPRO_RS13680	COG1960	acyl-CoA dehydrogenase activity
CYPRO_RS13695	COG0432	Pfam Uncharacterised protein family UPF0047
CYPRO_RS13715	COG3842	ATPase activity
CYPRO_RS13725	COG2967	ApaG domain
CYPRO_RS13760	COG0386	Belongs to the glutathione peroxidase family
CYPRO_RS13775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CYPRO_RS13775	COG0321	lipoyl(octanoyl) transferase activity
CYPRO_RS13785	COG0193	aminoacyl-tRNA hydrolase activity
CYPRO_RS13790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CYPRO_RS13795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYPRO_RS13820	COG5002	protein histidine kinase activity
CYPRO_RS13830	COG0632	four-way junction helicase activity
CYPRO_RS13835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CYPRO_RS13840	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYPRO_RS13850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYPRO_RS13855	COG0228	four-way junction DNA binding
CYPRO_RS13860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYPRO_RS13865	COG0336	Belongs to the RNA methyltransferase TrmD family
CYPRO_RS13870	COG0335	large ribosomal subunit rRNA binding
CYPRO_RS13880	COG0489	protein tyrosine kinase activity
CYPRO_RS13900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CYPRO_RS13905	COG2172	sigma factor antagonist activity
CYPRO_RS13910	COG0113	porphobilinogen synthase activity
CYPRO_RS13915	COG0408	coproporphyrinogen oxidase activity
CYPRO_RS13920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYPRO_RS13930	COG0181	hydroxymethylbilane synthase activity
CYPRO_RS13935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYPRO_RS13940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYPRO_RS13945	COG3852	Histidine kinase
CYPRO_RS13955	COG2770	Histidine kinase
CYPRO_RS13955	COG2208	phosphoserine phosphatase activity
CYPRO_RS13980	COG4232	protein-disulfide reductase activity
CYPRO_RS13985	COG4232	protein-disulfide reductase activity
CYPRO_RS14010	COG3015	lipoprotein NlpE involved in copper resistance
CYPRO_RS14020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYPRO_RS14025	COG1760	l-serine dehydratase
CYPRO_RS14040	COG0405	Gamma-glutamyltransferase
CYPRO_RS14055	COG0673	inositol 2-dehydrogenase activity
CYPRO_RS14075	COG1373	ATPase (AAA superfamily
CYPRO_RS14105	COG0385	Bile acid
CYPRO_RS14120	COG5002	protein histidine kinase activity
CYPRO_RS14125	COG0514	ATP-dependent DNA helicase (RecQ)
CYPRO_RS14130	COG2133	pyrroloquinoline quinone binding
CYPRO_RS14150	COG0415	Belongs to the DNA photolyase family
CYPRO_RS14155	COG3046	protein related to deoxyribodipyrimidine photolyase
CYPRO_RS14245	COG1836	PFAM Integral membrane protein DUF92
CYPRO_RS14250	COG1301	dicarboxylic acid transport
CYPRO_RS14265	COG0424	maF-like protein
CYPRO_RS14280	COG3956	TIGRFAM MazG family protein
CYPRO_RS14285	COG0372	Belongs to the citrate synthase family
CYPRO_RS14295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CYPRO_RS14370	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS14405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYPRO_RS14420	COG0723	plastoquinol--plastocyanin reductase activity
CYPRO_RS14440	COG2234	aminopeptidase activity
CYPRO_RS14450	COG0631	protein serine/threonine phosphatase activity
CYPRO_RS14485	COG1959	2 iron, 2 sulfur cluster binding
CYPRO_RS14490	COG2217	Heavy metal translocating P-type atpase
CYPRO_RS14500	COG3278	Belongs to the heme-copper respiratory oxidase family
CYPRO_RS14510	COG2010	Cytochrome c
CYPRO_RS14525	COG1561	YicC-like family, N-terminal region
CYPRO_RS14530	COG0194	GDP metabolic process
CYPRO_RS14540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CYPRO_RS14555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYPRO_RS14560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CYPRO_RS14565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYPRO_RS14570	COG2226	methyltransferase
CYPRO_RS14600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYPRO_RS14605	COG1366	Belongs to the anti-sigma-factor antagonist family
CYPRO_RS14610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYPRO_RS14615	COG1480	7TM receptor with intracellular HD hydrolase
CYPRO_RS14620	COG4974	Belongs to the 'phage' integrase family
CYPRO_RS14625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CYPRO_RS14630	COG1418	mRNA catabolic process
CYPRO_RS14635	COG0009	L-threonylcarbamoyladenylate synthase
CYPRO_RS14640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CYPRO_RS14645	COG0109	protoheme IX farnesyltransferase activity
CYPRO_RS14670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYPRO_RS14675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CYPRO_RS14710	COG0437	4 iron, 4 sulfur cluster binding
CYPRO_RS14725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYPRO_RS14765	COG4191	Histidine kinase
CYPRO_RS14775	COG0471	metal ion transport
CYPRO_RS14785	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CYPRO_RS14795	COG0330	HflC and HflK could
CYPRO_RS14805	COG0788	formyltetrahydrofolate deformylase activity
CYPRO_RS14810	COG1690	Belongs to the RtcB family
CYPRO_RS14820	COG2116	formate transmembrane transporter activity
CYPRO_RS14830	COG0004	ammonium transporteR
CYPRO_RS14870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CYPRO_RS14890	COG0328	RNA-DNA hybrid ribonuclease activity
CYPRO_RS14900	COG1082	Xylose isomerase domain protein TIM barrel
CYPRO_RS14925	COG2081	HI0933 family
CYPRO_RS14945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYPRO_RS14950	COG1461	Dihydroxyacetone kinase
CYPRO_RS14955	COG2376	Dihydroxyacetone kinase
CYPRO_RS14965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CYPRO_RS14970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CYPRO_RS15000	COG1193	negative regulation of DNA recombination
CYPRO_RS15010	COG5002	protein histidine kinase activity
CYPRO_RS15045	COG3275	phosphorelay sensor kinase activity
CYPRO_RS15050	COG3279	Response regulator of the LytR AlgR family
CYPRO_RS15090	COG0826	peptidase U32
CYPRO_RS15100	COG0495	leucyl-tRNA aminoacylation
CYPRO_RS15105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYPRO_RS15130	COG0018	arginyl-trna synthetase
CYPRO_RS15135	COG2003	Belongs to the UPF0758 family
CYPRO_RS15140	COG0822	iron-sulfur transferase activity
CYPRO_RS15145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CYPRO_RS15155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYPRO_RS15165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CYPRO_RS15170	COG3001	Fructosamine kinase
CYPRO_RS15175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYPRO_RS15225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CYPRO_RS15230	COG0248	Ppx GppA phosphatase
CYPRO_RS15235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYPRO_RS15235	COG3153	acetyltransferase
CYPRO_RS15245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYPRO_RS15250	COG0505	Belongs to the CarA family
CYPRO_RS15260	COG4372	Transposase
CYPRO_RS15275	COG0537	adenosine 5'-monophosphoramidase activity
CYPRO_RS15305	COG1487	ribonuclease activity
CYPRO_RS15335	COG0492	ferredoxin-NADP+ reductase activity
CYPRO_RS15340	COG0471	metal ion transport
CYPRO_RS15355	COG1620	l-lactate permease
CYPRO_RS15370	COG1012	belongs to the aldehyde dehydrogenase family
CYPRO_RS15395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYPRO_RS15410	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CYPRO_RS15420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYPRO_RS15465	COG1131	(ABC) transporter
CYPRO_RS15470	COG2135	peptidase activity
CYPRO_RS15475	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CYPRO_RS15480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYPRO_RS15525	COG0668	transmembrane transport
CYPRO_RS15530	COG0300	oxidoreductase activity
CYPRO_RS15560	COG0523	cobalamin synthesis protein
CYPRO_RS15565	COG1054	Belongs to the UPF0176 family
CYPRO_RS15570	COG0564	pseudouridine synthase activity
CYPRO_RS15580	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYPRO_RS15585	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYPRO_RS15590	COG0427	acetyl-CoA hydrolase
CYPRO_RS15610	COG0513	Belongs to the DEAD box helicase family
CYPRO_RS15625	COG1215	transferase activity, transferring glycosyl groups
CYPRO_RS15645	COG0823	Involved in the tonB-independent uptake of proteins
CYPRO_RS15645	COG1506	peptidase
CYPRO_RS15665	COG1228	amidohydrolase
CYPRO_RS15670	COG0402	S-adenosylhomocysteine deaminase activity
CYPRO_RS15740	COG1518	maintenance of DNA repeat elements
CYPRO_RS15745	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CYPRO_RS15775	COG1337	RAMP superfamily
CYPRO_RS15790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CYPRO_RS15880	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CYPRO_RS15885	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS15890	COG0217	transcriptional regulatory protein
CYPRO_RS15910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYPRO_RS15955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYPRO_RS15990	COG1943	Transposase
CYPRO_RS16095	COG0287	Prephenate dehydrogenase
CYPRO_RS16095	COG1605	Chorismate mutase
CYPRO_RS16105	COG0700	Nucleoside recognition
CYPRO_RS16110	COG2715	membrane protein required for spore maturation
CYPRO_RS16130	COG2911	Protein conserved in bacteria
CYPRO_RS16135	COG0729	surface antigen
CYPRO_RS16160	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CYPRO_RS16185	COG1013	pyruvate-flavodoxin oxidoreductase activity
CYPRO_RS16190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CYPRO_RS16190	COG0674	pyruvate-flavodoxin oxidoreductase activity
CYPRO_RS16195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYPRO_RS16220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CYPRO_RS16235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYPRO_RS16245	COG2197	response regulator
CYPRO_RS16265	COG0564	pseudouridine synthase activity
CYPRO_RS16280	COG1401	restriction endodeoxyribonuclease activity
CYPRO_RS16315	COG0438	transferase activity, transferring glycosyl groups
CYPRO_RS16335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYPRO_RS16350	COG4191	Histidine kinase
CYPRO_RS16355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYPRO_RS16360	COG0724	RNA recognition motif
CYPRO_RS16365	COG0148	phosphopyruvate hydratase activity
CYPRO_RS16370	COG0546	phosphoglycolate phosphatase activity
CYPRO_RS16385	COG2890	protein-(glutamine-N5) methyltransferase activity