locus-tag	class	description
BARVI_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BARVI_RS00035	COG1640	4-alpha-glucanotransferase
BARVI_RS00040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BARVI_RS00045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BARVI_RS00050	COG3119	arylsulfatase activity
BARVI_RS00055	COG1501	Belongs to the glycosyl hydrolase 31 family
BARVI_RS00090	COG1629	transport
BARVI_RS00100	COG4771	TonB-dependent receptor
BARVI_RS00105	COG0702	epimerase
BARVI_RS00120	COG3537	Alpha-1,2-mannosidase
BARVI_RS00130	COG2081	HI0933 family
BARVI_RS00135	COG0673	inositol 2-dehydrogenase activity
BARVI_RS00155	COG0574	Belongs to the PEP-utilizing enzyme family
BARVI_RS00155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BARVI_RS00160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BARVI_RS00165	COG0641	radical SAM
BARVI_RS00175	COG3119	arylsulfatase activity
BARVI_RS00215	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BARVI_RS00220	COG0194	GDP metabolic process
BARVI_RS00230	COG1214	PFAM Peptidase M22, glycoprotease
BARVI_RS00240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BARVI_RS00245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BARVI_RS00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BARVI_RS00270	COG2022	thiamine diphosphate biosynthetic process
BARVI_RS00275	COG0352	thiamine-phosphate diphosphorylase activity
BARVI_RS00280	COG0352	thiamine-phosphate diphosphorylase activity
BARVI_RS00290	COG0351	phosphomethylpyrimidine kinase
BARVI_RS00290	COG0352	thiamine-phosphate diphosphorylase activity
BARVI_RS00295	COG0069	glutamate synthase activity
BARVI_RS00295	COG0070	glutamate synthase
BARVI_RS00295	COG0067	glutamate synthase
BARVI_RS00305	COG0367	asparagine synthase
BARVI_RS00335	COG3206	protein involved in exopolysaccharide biosynthesis
BARVI_RS00335	COG0489	protein tyrosine kinase activity
BARVI_RS00355	COG0562	UDP-galactopyranose mutase
BARVI_RS00360	COG1216	Glycosyl transferase, family 2
BARVI_RS00375	COG0438	transferase activity, transferring glycosyl groups
BARVI_RS00390	COG1216	Glycosyl transferase, family 2
BARVI_RS00400	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BARVI_RS00405	COG2089	acid synthase
BARVI_RS00410	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BARVI_RS00415	COG3594	Acyltransferase
BARVI_RS00435	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BARVI_RS00440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BARVI_RS00455	COG1595	DNA-templated transcription, initiation
BARVI_RS00465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BARVI_RS00490	COG0750	zinc metalloprotease
BARVI_RS00495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BARVI_RS00505	COG2885	chlorophyll binding
BARVI_RS00520	COG0066	3-isopropylmalate dehydratase activity
BARVI_RS00525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BARVI_RS00530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BARVI_RS00540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BARVI_RS00545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BARVI_RS00550	COG1295	ribonuclease BN
BARVI_RS00555	COG0251	oxidation-reduction process
BARVI_RS00560	COG0285	dihydrofolate synthase activity
BARVI_RS00575	COG3118	belongs to the thioredoxin family
BARVI_RS00585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BARVI_RS00595	COG0602	queuosine metabolic process
BARVI_RS00605	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BARVI_RS00640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BARVI_RS00645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BARVI_RS00665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BARVI_RS00670	COG0776	regulation of translation
BARVI_RS00675	COG0776	regulation of translation
BARVI_RS00680	COG0714	Associated with various cellular activities
BARVI_RS00700	COG2304	oxidoreductase activity
BARVI_RS00720	COG0671	phosphoesterase, PA-phosphatase related
BARVI_RS00735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BARVI_RS00740	COG0459	protein refolding
BARVI_RS00755	COG0793	Belongs to the peptidase S41A family
BARVI_RS00760	COG2832	Protein of unknown function (DUF454)
BARVI_RS00770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BARVI_RS00775	COG0505	Belongs to the CarA family
BARVI_RS00780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BARVI_RS00785	COG0436	Aminotransferase
BARVI_RS00800	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BARVI_RS00800	COG1918	ferrous iron import across plasma membrane
BARVI_RS00840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BARVI_RS00845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BARVI_RS00855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BARVI_RS00930	COG0668	transmembrane transport
BARVI_RS00935	COG0432	Pfam Uncharacterised protein family UPF0047
BARVI_RS00950	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BARVI_RS00955	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BARVI_RS00955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BARVI_RS00960	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BARVI_RS00965	COG0156	8-amino-7-oxononanoate synthase activity
BARVI_RS00975	COG3850	Histidine kinase
BARVI_RS00975	COG5002	protein histidine kinase activity
BARVI_RS00980	COG0745	RESPONSE REGULATOR receiver
BARVI_RS00985	COG1773	rubredoxin
BARVI_RS01005	COG0534	Mate efflux family protein
BARVI_RS01015	COG0488	(ABC) transporter
BARVI_RS01050	COG1388	LysM domain
BARVI_RS01050	COG3942	CHAP domain
BARVI_RS01060	COG1388	LysM domain
BARVI_RS01060	COG0741	lytic transglycosylase activity
BARVI_RS01065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BARVI_RS01075	COG0543	2 iron, 2 sulfur cluster binding
BARVI_RS01080	COG0167	dihydroorotate dehydrogenase activity
BARVI_RS01090	COG0542	response to heat
BARVI_RS01110	COG1346	cytolysis
BARVI_RS01115	COG1380	Effector of murein hydrolase LrgA
BARVI_RS01125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BARVI_RS01125	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BARVI_RS01155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BARVI_RS01160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BARVI_RS01165	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BARVI_RS01180	COG1966	Carbon starvation protein
BARVI_RS01190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BARVI_RS01200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BARVI_RS01215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BARVI_RS01220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BARVI_RS01230	COG0436	Aminotransferase
BARVI_RS01235	COG4591	ABC-type transport system involved in lipoprotein release permease component
BARVI_RS01240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BARVI_RS01245	COG0481	GTPase activity
BARVI_RS01250	COG1592	Rubrerythrin
BARVI_RS01250	COG1773	rubredoxin
BARVI_RS01260	COG0019	diaminopimelate decarboxylase activity
BARVI_RS01265	COG0527	aspartate kinase activity
BARVI_RS01270	COG2884	Cell division ATP-binding protein ftsE
BARVI_RS01275	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BARVI_RS01275	COG0140	phosphoribosyl-ATP diphosphatase activity
BARVI_RS01280	COG0107	imidazoleglycerol-phosphate synthase activity
BARVI_RS01285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BARVI_RS01295	COG5434	Belongs to the glycosyl hydrolase 28 family
BARVI_RS01305	COG3385	transposase activity
BARVI_RS01310	COG3250	beta-galactosidase activity
BARVI_RS01315	COG4948	Mandelate Racemase Muconate Lactonizing
BARVI_RS01320	COG2755	lipolytic protein G-D-S-L family
BARVI_RS01320	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BARVI_RS01345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BARVI_RS01355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BARVI_RS01380	COG0357	Ribosomal RNA small subunit methyltransferase G
BARVI_RS01385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BARVI_RS01395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BARVI_RS01405	COG1193	negative regulation of DNA recombination
BARVI_RS01420	COG0321	lipoyl(octanoyl) transferase activity
BARVI_RS01420	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BARVI_RS01425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BARVI_RS01465	COG4948	Mandelate Racemase Muconate Lactonizing
BARVI_RS01470	COG2116	formate transmembrane transporter activity
BARVI_RS01475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BARVI_RS01485	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BARVI_RS01495	COG3956	TIGRFAM MazG family protein
BARVI_RS01515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BARVI_RS01525	COG0037	tRNA processing
BARVI_RS01530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BARVI_RS01535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BARVI_RS01540	COG1482	cell wall glycoprotein biosynthetic process
BARVI_RS01545	COG1649	PFAM Uncharacterised BCR, COG1649
BARVI_RS01560	COG0463	Glycosyl transferase, family 2
BARVI_RS01565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BARVI_RS01570	COG0745	RESPONSE REGULATOR receiver
BARVI_RS01575	COG5002	protein histidine kinase activity
BARVI_RS01595	COG1022	Amp-dependent synthetase and ligase
BARVI_RS01605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BARVI_RS01615	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
BARVI_RS01615	COG2878	Part of a membrane complex involved in electron transport
BARVI_RS01620	COG4656	Part of a membrane complex involved in electron transport
BARVI_RS01625	COG4658	electron transport chain
BARVI_RS01635	COG4660	Part of a membrane complex involved in electron transport
BARVI_RS01640	COG4657	Part of a membrane complex involved in electron transport
BARVI_RS01670	COG1595	DNA-templated transcription, initiation
BARVI_RS01730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BARVI_RS01750	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BARVI_RS01755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BARVI_RS01760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BARVI_RS01775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BARVI_RS01780	COG0509	glycine decarboxylation via glycine cleavage system
BARVI_RS01785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BARVI_RS01790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BARVI_RS01795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BARVI_RS01805	COG0358	DNA primase activity
BARVI_RS01810	COG4152	abc transporter atp-binding protein
BARVI_RS01825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BARVI_RS01845	COG0058	SHG alpha-glucan phosphorylase activity
BARVI_RS01850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BARVI_RS01855	COG0284	orotidine-5'-phosphate decarboxylase activity
BARVI_RS01860	COG0126	phosphoglycerate kinase activity
BARVI_RS01895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BARVI_RS01895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BARVI_RS01900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BARVI_RS01910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BARVI_RS01915	COG2264	protein methyltransferase activity
BARVI_RS01965	COG1404	Belongs to the peptidase S8 family
BARVI_RS01980	COG0339	signal peptide processing
BARVI_RS01995	COG2954	triphosphatase activity
BARVI_RS02015	COG2814	Major facilitator Superfamily
BARVI_RS02030	COG0513	Belongs to the DEAD box helicase family
BARVI_RS02040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BARVI_RS02060	COG1760	l-serine dehydratase
BARVI_RS02070	COG2814	Major facilitator Superfamily
BARVI_RS02075	COG0360	Binds together with S18 to 16S ribosomal RNA
BARVI_RS02080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BARVI_RS02085	COG0359	binds to the 23S rRNA
BARVI_RS02115	COG2131	deaminase
BARVI_RS02120	COG0793	Belongs to the peptidase S41A family
BARVI_RS02120	COG3409	Peptidoglycan-binding domain 1 protein
BARVI_RS02145	COG3655	Transcriptional regulator
BARVI_RS02150	COG0612	Peptidase, M16
BARVI_RS02245	COG1132	(ABC) transporter
BARVI_RS02295	COG4771	TonB-dependent receptor
BARVI_RS02360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BARVI_RS02365	COG2086	electron transfer activity
BARVI_RS02370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BARVI_RS02380	COG1012	belongs to the aldehyde dehydrogenase family
BARVI_RS02405	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BARVI_RS02455	COG4974	Belongs to the 'phage' integrase family
BARVI_RS02460	COG4974	Belongs to the 'phage' integrase family
BARVI_RS02465	COG4974	Belongs to the 'phage' integrase family
BARVI_RS02470	COG3328	transposase activity
BARVI_RS02550	COG0210	DNA helicase
BARVI_RS02615	COG2204	response regulator
BARVI_RS02620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BARVI_RS02620	COG2205	protein histidine kinase activity
BARVI_RS02625	COG1393	Belongs to the ArsC family
BARVI_RS02630	COG0228	four-way junction DNA binding
BARVI_RS02645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BARVI_RS02665	COG1757	Na H antiporter
BARVI_RS02695	COG1629	transport
BARVI_RS02695	COG4206	TonB-dependent receptor
BARVI_RS02715	COG0484	heat shock protein binding
BARVI_RS02720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BARVI_RS02725	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BARVI_RS02730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BARVI_RS02730	COG2755	lipolytic protein G-D-S-L family
BARVI_RS02740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BARVI_RS02745	COG0305	Participates in initiation and elongation during chromosome replication
BARVI_RS02750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BARVI_RS02765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BARVI_RS02770	COG0525	valine-tRNA ligase activity
BARVI_RS02775	COG3119	arylsulfatase activity
BARVI_RS02805	COG4771	TonB-dependent receptor
BARVI_RS02815	COG2205	protein histidine kinase activity
BARVI_RS02815	COG3292	Two component regulator propeller
BARVI_RS02815	COG0745	RESPONSE REGULATOR receiver
BARVI_RS02815	COG2205	protein histidine kinase activity
BARVI_RS02815	COG0745	RESPONSE REGULATOR receiver
BARVI_RS02815	COG3292	Two component regulator propeller
BARVI_RS02885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BARVI_RS02890	COG0673	inositol 2-dehydrogenase activity
BARVI_RS02935	COG3119	arylsulfatase activity
BARVI_RS02940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BARVI_RS02945	COG3119	arylsulfatase activity
BARVI_RS02950	COG0702	epimerase
BARVI_RS02955	COG4771	TonB-dependent receptor
BARVI_RS02970	COG2205	protein histidine kinase activity
BARVI_RS02970	COG3292	Two component regulator propeller
BARVI_RS02970	COG3292	Two component regulator propeller
BARVI_RS02970	COG2205	protein histidine kinase activity
BARVI_RS02970	COG0745	RESPONSE REGULATOR receiver
BARVI_RS02970	COG0745	RESPONSE REGULATOR receiver
BARVI_RS02980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BARVI_RS03000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BARVI_RS03050	COG3119	arylsulfatase activity
BARVI_RS03055	COG0039	L-malate dehydrogenase activity
BARVI_RS03085	COG3275	phosphorelay sensor kinase activity
BARVI_RS03105	COG1621	beta-fructofuranosidase activity
BARVI_RS03120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BARVI_RS03125	COG0745	RESPONSE REGULATOR receiver
BARVI_RS03125	COG2205	protein histidine kinase activity
BARVI_RS03125	COG3292	Two component regulator propeller
BARVI_RS03130	COG0561	phosphatase activity
BARVI_RS03135	COG4566	intracellular signal transduction
BARVI_RS03165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BARVI_RS03170	COG0497	DNA recombination
BARVI_RS03185	COG2176	DNA-directed DNA polymerase activity
BARVI_RS03185	COG5002	protein histidine kinase activity
BARVI_RS03220	COG0302	gtp cyclohydrolase
BARVI_RS03230	COG0149	triose-phosphate isomerase activity
BARVI_RS03250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BARVI_RS03255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BARVI_RS03260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BARVI_RS03265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BARVI_RS03295	COG3590	peptidase
BARVI_RS03300	COG0488	(ABC) transporter
BARVI_RS03310	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BARVI_RS03325	COG0616	signal peptide processing
BARVI_RS03330	COG1663	tetraacyldisaccharide 4'-kinase activity
BARVI_RS03340	COG0450	alkyl hydroperoxide reductase
BARVI_RS03345	COG0583	DNA-binding transcription factor activity
BARVI_RS03360	COG0129	dihydroxy-acid dehydratase activity
BARVI_RS03365	COG0028	Belongs to the TPP enzyme family
BARVI_RS03380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BARVI_RS03390	COG0706	membrane insertase activity
BARVI_RS03395	COG0504	CTP synthase activity
BARVI_RS03430	COG0297	glycogen (starch) synthase activity
BARVI_RS03430	COG0438	transferase activity, transferring glycosyl groups
BARVI_RS03435	COG0535	radical SAM domain protein
BARVI_RS03475	COG3206	protein involved in exopolysaccharide biosynthesis
BARVI_RS03475	COG0489	protein tyrosine kinase activity
BARVI_RS03485	COG1215	transferase activity, transferring glycosyl groups
BARVI_RS03500	COG1575	Belongs to the MenA family. Type 1 subfamily
BARVI_RS03510	COG0307	riboflavin synthase, alpha
BARVI_RS03515	COG0778	Nitroreductase
BARVI_RS03585	COG0732	type I restriction modification DNA specificity domain
BARVI_RS03610	COG4974	Belongs to the 'phage' integrase family
BARVI_RS03615	COG4974	Belongs to the 'phage' integrase family
BARVI_RS03715	COG3385	transposase activity
BARVI_RS03750	COG1196	nuclear chromosome segregation
BARVI_RS03830	COG1404	Belongs to the peptidase S8 family
BARVI_RS03850	COG0445	tRNA wobble uridine modification
BARVI_RS03880	COG4864	UPF0365 protein
BARVI_RS03890	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BARVI_RS03915	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BARVI_RS03935	COG1131	(ABC) transporter
BARVI_RS03960	COG1595	DNA-templated transcription, initiation
BARVI_RS03970	COG0343	queuine tRNA-ribosyltransferase activity
BARVI_RS03980	COG0542	response to heat
BARVI_RS03995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BARVI_RS04000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BARVI_RS04005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BARVI_RS04010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BARVI_RS04045	COG0586	Pfam SNARE associated Golgi protein
BARVI_RS04055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BARVI_RS04065	COG3142	Participates in the control of copper homeostasis
BARVI_RS04080	COG0534	Mate efflux family protein
BARVI_RS04090	COG1595	DNA-templated transcription, initiation
BARVI_RS04105	COG1629	transport
BARVI_RS04105	COG4206	TonB-dependent receptor
BARVI_RS04130	COG3537	Alpha-1,2-mannosidase
BARVI_RS04135	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BARVI_RS04140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BARVI_RS04145	COG2807	transmembrane transport
BARVI_RS04150	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BARVI_RS04160	COG0519	Catalyzes the synthesis of GMP from XMP
BARVI_RS04160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BARVI_RS04165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BARVI_RS04165	COG4651	solute:proton antiporter activity
BARVI_RS04170	COG1285	pathogenesis
BARVI_RS04205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BARVI_RS04215	COG0805	protein transport
BARVI_RS04230	COG1752	Esterase of the alpha-beta hydrolase superfamily
BARVI_RS04260	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BARVI_RS04290	COG0583	DNA-binding transcription factor activity
BARVI_RS04295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BARVI_RS04345	COG2207	Transcriptional regulator
BARVI_RS04355	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BARVI_RS04360	COG0511	ligase activity, forming carbon-carbon bonds
BARVI_RS04370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BARVI_RS04375	COG0346	lactoylglutathione lyase activity
BARVI_RS04380	COG0443	Heat shock 70 kDa protein
BARVI_RS04405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BARVI_RS04425	COG0009	L-threonylcarbamoyladenylate synthase
BARVI_RS04430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BARVI_RS04440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BARVI_RS04450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BARVI_RS04455	COG1196	nuclear chromosome segregation
BARVI_RS04465	COG0612	Peptidase, M16
BARVI_RS04470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BARVI_RS04510	COG0632	four-way junction helicase activity
BARVI_RS04525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BARVI_RS04545	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BARVI_RS04570	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BARVI_RS04575	COG1940	carbohydrate kinase activity
BARVI_RS04580	COG0493	'glutamate synthase
BARVI_RS04580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BARVI_RS04585	COG0543	2 iron, 2 sulfur cluster binding
BARVI_RS04635	COG0438	transferase activity, transferring glycosyl groups
BARVI_RS04645	COG3119	arylsulfatase activity
BARVI_RS04650	COG3119	arylsulfatase activity
BARVI_RS04655	COG0217	transcriptional regulatory protein
BARVI_RS04670	COG0688	phosphatidylethanolamine metabolic process
BARVI_RS04675	COG1183	phosphatidylcholine synthase activity
BARVI_RS04690	COG2195	Cleaves the N-terminal amino acid of tripeptides
BARVI_RS04700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BARVI_RS04705	COG2239	Acts as a magnesium transporter
BARVI_RS04715	COG3829	transcription factor binding
BARVI_RS04745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BARVI_RS04750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BARVI_RS04755	COG0842	Transport permease protein
BARVI_RS04760	COG0842	Transport permease protein
BARVI_RS04765	COG1131	(ABC) transporter
BARVI_RS04770	COG1131	(ABC) transporter
BARVI_RS04785	COG1309	transcriptional regulator
BARVI_RS04795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BARVI_RS04800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BARVI_RS04810	COG1253	flavin adenine dinucleotide binding
BARVI_RS04840	COG1629	transport
BARVI_RS04840	COG4206	TonB-dependent receptor
BARVI_RS04845	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BARVI_RS04885	COG0772	Belongs to the SEDS family
BARVI_RS04890	COG0768	penicillin binding
BARVI_RS04910	COG0138	bifunctional purine biosynthesis protein purh
BARVI_RS04915	COG4206	TonB-dependent receptor
BARVI_RS04915	COG1629	transport
BARVI_RS04925	COG0716	FMN binding
BARVI_RS04935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BARVI_RS04940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BARVI_RS04945	COG0363	glucosamine-6-phosphate deaminase activity
BARVI_RS04950	COG0336	Belongs to the RNA methyltransferase TrmD family
BARVI_RS04955	COG0488	(ABC) transporter
BARVI_RS04970	COG0826	peptidase U32
BARVI_RS04990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BARVI_RS05000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BARVI_RS05005	COG0596	Alpha beta hydrolase
BARVI_RS05010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BARVI_RS05015	COG1181	Belongs to the D-alanine--D-alanine ligase family
BARVI_RS05025	COG0488	(ABC) transporter
BARVI_RS05030	COG0242	peptide deformylase activity
BARVI_RS05035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BARVI_RS05040	COG3537	Alpha-1,2-mannosidase
BARVI_RS05060	COG0793	Belongs to the peptidase S41A family
BARVI_RS05075	COG0423	glycine-tRNA ligase activity
BARVI_RS05080	COG1704	LemA family
BARVI_RS05090	COG0704	Plays a role in the regulation of phosphate uptake
BARVI_RS05100	COG1047	Peptidyl-prolyl cis-trans
BARVI_RS05125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BARVI_RS05130	COG1530	ribonuclease E activity
BARVI_RS05135	COG0776	regulation of translation
BARVI_RS05140	COG1253	flavin adenine dinucleotide binding
BARVI_RS05165	COG1242	4 iron, 4 sulfur cluster binding
BARVI_RS05175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BARVI_RS05190	COG2885	chlorophyll binding
BARVI_RS05205	COG0739	heme binding
BARVI_RS05220	COG0733	neurotransmitter:sodium symporter activity
BARVI_RS05230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BARVI_RS05235	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BARVI_RS05240	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BARVI_RS05245	COG1217	gtp-binding protein TYPA
BARVI_RS05250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BARVI_RS05275	COG0438	transferase activity, transferring glycosyl groups
BARVI_RS05285	COG2095	MarC family integral membrane protein
BARVI_RS05325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BARVI_RS05335	COG0590	tRNA wobble adenosine to inosine editing
BARVI_RS05340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BARVI_RS05345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BARVI_RS05360	COG1678	Uncharacterized ACR, COG1678
BARVI_RS05365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BARVI_RS05385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BARVI_RS05390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BARVI_RS05395	COG0166	Belongs to the GPI family
BARVI_RS05400	COG1501	Belongs to the glycosyl hydrolase 31 family
BARVI_RS05415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BARVI_RS05425	COG2814	Major facilitator Superfamily
BARVI_RS05440	COG1595	DNA-templated transcription, initiation
BARVI_RS05445	COG1030	water channel activity
BARVI_RS05450	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BARVI_RS05480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BARVI_RS05500	COG1131	(ABC) transporter
BARVI_RS05500	COG1716	ATPase activity
BARVI_RS05500	COG0842	Transport permease protein
BARVI_RS05505	COG3250	beta-galactosidase activity
BARVI_RS05550	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BARVI_RS05550	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BARVI_RS05560	COG4804	nuclease activity
BARVI_RS05565	COG2226	methyltransferase
BARVI_RS05570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BARVI_RS05575	COG1702	phosphate starvation-inducible protein PhoH
BARVI_RS05595	COG2351	hydroxyisourate hydrolase activity
BARVI_RS05615	COG0084	hydrolase, TatD family'
BARVI_RS05640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BARVI_RS05645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BARVI_RS05650	COG0205	6-phosphofructokinase activity
BARVI_RS05665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BARVI_RS05670	COG1480	7TM receptor with intracellular HD hydrolase
BARVI_RS05705	COG1854	S-ribosylhomocysteine lyase activity
BARVI_RS05710	COG0716	FMN binding
BARVI_RS05720	COG0436	Aminotransferase
BARVI_RS05755	COG1132	(ABC) transporter
BARVI_RS05760	COG0463	Glycosyl transferase, family 2
BARVI_RS05785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BARVI_RS05795	COG1705	Flagellar rod assembly protein muramidase FlgJ
BARVI_RS05800	COG0295	cytidine deaminase activity
BARVI_RS05805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BARVI_RS05825	COG3250	beta-galactosidase activity
BARVI_RS05845	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BARVI_RS05850	COG0527	aspartate kinase activity
BARVI_RS05850	COG0460	homoserine dehydrogenase
BARVI_RS05860	COG0252	asparaginase activity
BARVI_RS05870	COG1477	protein flavinylation
BARVI_RS05875	COG1971	Probably functions as a manganese efflux pump
BARVI_RS05890	COG1595	DNA-templated transcription, initiation
BARVI_RS05895	COG0428	transporter
BARVI_RS05900	COG4771	TonB-dependent receptor
BARVI_RS05910	COG0463	Glycosyl transferase, family 2
BARVI_RS05910	COG1216	Glycosyl transferase, family 2
BARVI_RS05940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BARVI_RS05955	COG1733	regulation of RNA biosynthetic process
BARVI_RS05990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BARVI_RS05995	COG0124	histidyl-tRNA synthetase
BARVI_RS06060	COG1271	oxidase subunit
BARVI_RS06065	COG1294	oxidase, subunit
BARVI_RS06070	COG1739	Uncharacterized protein family UPF0029
BARVI_RS06075	COG0110	maltose O-acetyltransferase activity
BARVI_RS06080	COG1011	Hydrolase
BARVI_RS06090	COG1496	oxidoreductase activity
BARVI_RS06095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BARVI_RS06105	COG0563	adenylate kinase activity
BARVI_RS06110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BARVI_RS06115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BARVI_RS06125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BARVI_RS06150	COG3104	oligopeptide transport
BARVI_RS06155	COG2166	iron-sulfur cluster assembly
BARVI_RS06160	COG2234	aminopeptidase activity
BARVI_RS06165	COG1619	proteins homologs of microcin C7 resistance protein MccF
BARVI_RS06170	COG1160	GTP binding
BARVI_RS06175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BARVI_RS06180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BARVI_RS06260	COG4804	nuclease activity
BARVI_RS06335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BARVI_RS06360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BARVI_RS06370	COG1970	mechanosensitive ion channel activity
BARVI_RS06375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BARVI_RS06405	COG0489	protein tyrosine kinase activity
BARVI_RS06410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BARVI_RS06415	COG1013	pyruvate-flavodoxin oxidoreductase activity
BARVI_RS06420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BARVI_RS06420	COG0674	pyruvate-flavodoxin oxidoreductase activity
BARVI_RS06425	COG0686	Belongs to the AlaDH PNT family
BARVI_RS06430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BARVI_RS06440	COG3341	Caulimovirus viroplasmin
BARVI_RS06440	COG0328	RNA-DNA hybrid ribonuclease activity
BARVI_RS06470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BARVI_RS06475	COG1610	YqeY-like protein
BARVI_RS06480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BARVI_RS06485	COG0849	cell division
BARVI_RS06495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BARVI_RS06500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BARVI_RS06505	COG0772	Belongs to the SEDS family
BARVI_RS06510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BARVI_RS06515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BARVI_RS06520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BARVI_RS06525	COG0768	penicillin binding
BARVI_RS06535	COG0275	rRNA processing
BARVI_RS06560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BARVI_RS06565	COG0612	Peptidase, M16
BARVI_RS06585	COG2096	Adenosyltransferase
BARVI_RS06640	COG4974	Belongs to the 'phage' integrase family
BARVI_RS06665	COG4804	nuclease activity
BARVI_RS06670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BARVI_RS06690	COG3385	transposase activity
BARVI_RS06730	COG2255	four-way junction helicase activity
BARVI_RS06750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BARVI_RS06755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BARVI_RS06760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BARVI_RS06765	COG0571	ribonuclease III activity
BARVI_RS06775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BARVI_RS06775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BARVI_RS06780	COG1216	Glycosyl transferase, family 2
BARVI_RS06800	COG2244	polysaccharide biosynthetic process
BARVI_RS06810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BARVI_RS06835	COG3250	beta-galactosidase activity
BARVI_RS06865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BARVI_RS06890	COG0517	IMP dehydrogenase activity
BARVI_RS06890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BARVI_RS06905	COG0513	Belongs to the DEAD box helicase family
BARVI_RS06920	COG0156	8-amino-7-oxononanoate synthase activity
BARVI_RS06930	COG0196	riboflavin kinase activity
BARVI_RS06955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BARVI_RS06970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BARVI_RS06985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BARVI_RS06995	COG1185	polyribonucleotide nucleotidyltransferase activity
BARVI_RS07010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BARVI_RS07015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BARVI_RS07025	COG1522	sequence-specific DNA binding
BARVI_RS07045	COG1131	(ABC) transporter
BARVI_RS07050	COG1131	(ABC) transporter
BARVI_RS07055	COG0842	Transport permease protein
BARVI_RS07065	COG0545	Peptidyl-prolyl cis-trans isomerase
BARVI_RS07070	COG0545	Peptidyl-prolyl cis-trans isomerase
BARVI_RS07080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BARVI_RS07085	COG1283	sodium-dependent phosphate transmembrane transporter activity
BARVI_RS07090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BARVI_RS07095	COG0142	geranyltranstransferase activity
BARVI_RS07100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BARVI_RS07100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BARVI_RS07105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BARVI_RS07110	COG0668	transmembrane transport
BARVI_RS07115	COG0012	GTP binding
BARVI_RS07120	COG0793	Belongs to the peptidase S41A family
BARVI_RS07125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BARVI_RS07145	COG0561	phosphatase activity
BARVI_RS07155	COG0657	acetylesterase activity
BARVI_RS07155	COG2755	lipolytic protein G-D-S-L family
BARVI_RS07170	COG2610	gluconate transmembrane transporter activity
BARVI_RS07175	COG1929	Belongs to the glycerate kinase type-1 family
BARVI_RS07210	COG0702	epimerase
BARVI_RS07215	COG4771	TonB-dependent receptor
BARVI_RS07225	COG1595	DNA-templated transcription, initiation
BARVI_RS07245	COG1694	Mazg nucleotide pyrophosphohydrolase
BARVI_RS07250	COG1490	D-aminoacyl-tRNA deacylase activity
BARVI_RS07255	COG0322	excinuclease ABC activity
BARVI_RS07260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BARVI_RS07265	COG0445	tRNA wobble uridine modification
BARVI_RS07270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BARVI_RS07275	COG0700	Nucleoside recognition
BARVI_RS07295	COG1505	serine-type exopeptidase activity
BARVI_RS07300	COG1592	Rubrerythrin
BARVI_RS07315	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BARVI_RS07335	COG1045	serine acetyltransferase
BARVI_RS07340	COG0116	Belongs to the methyltransferase superfamily
BARVI_RS07355	COG1238	metal cluster binding
BARVI_RS07360	COG0494	nUDIX hydrolase
BARVI_RS07370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BARVI_RS07375	COG2194	sulfuric ester hydrolase activity
BARVI_RS07385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BARVI_RS07390	COG0495	leucyl-tRNA aminoacylation
BARVI_RS07395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BARVI_RS07410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BARVI_RS07410	COG0731	radical SAM domain protein
BARVI_RS07425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BARVI_RS07430	COG1053	succinate dehydrogenase
BARVI_RS07440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BARVI_RS07450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BARVI_RS07460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BARVI_RS07465	COG0594	ribonuclease P activity
BARVI_RS07500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BARVI_RS07505	COG0363	glucosamine-6-phosphate deaminase activity
BARVI_RS07510	COG0363	glucosamine-6-phosphate deaminase activity
BARVI_RS07515	COG0427	acetyl-CoA hydrolase
BARVI_RS07525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BARVI_RS07530	COG2814	Major facilitator Superfamily
BARVI_RS07535	COG2177	Part of the ABC transporter FtsEX involved in
BARVI_RS07545	COG1968	undecaprenyl-diphosphatase activity
BARVI_RS07550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BARVI_RS07555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BARVI_RS07565	COG1328	CTP reductase activity
BARVI_RS07590	COG1136	(ABC) transporter
BARVI_RS07595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BARVI_RS07605	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BARVI_RS07610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BARVI_RS07620	COG3158	transport of potassium into the cell
BARVI_RS07625	COG0659	secondary active sulfate transmembrane transporter activity
BARVI_RS07635	COG0670	Belongs to the BI1 family
BARVI_RS07640	COG0018	arginyl-trna synthetase
BARVI_RS07645	COG2431	L-lysine efflux transmembrane transporter activity
BARVI_RS07665	COG1649	PFAM Uncharacterised BCR, COG1649
BARVI_RS07670	COG0464	growth
BARVI_RS07680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BARVI_RS07685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BARVI_RS07700	COG0606	chelatase, subunit chli
BARVI_RS07715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BARVI_RS07720	COG0826	peptidase U32
BARVI_RS07755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BARVI_RS07765	COG1381	Involved in DNA repair and RecF pathway recombination
BARVI_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
BARVI_RS07780	COG0667	Aldo Keto reductase
BARVI_RS07790	COG0268	Binds directly to 16S ribosomal RNA
BARVI_RS07805	COG0187	DNA topoisomerase II activity
BARVI_RS07820	COG0557	exoribonuclease II activity
BARVI_RS07830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BARVI_RS07835	COG0793	Belongs to the peptidase S41A family
BARVI_RS07840	COG0339	signal peptide processing
BARVI_RS07865	COG0475	glutathione-regulated potassium exporter activity
BARVI_RS07865	COG0589	response to stress
BARVI_RS07870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BARVI_RS07890	COG0756	dUTP diphosphatase activity
BARVI_RS07920	COG1215	transferase activity, transferring glycosyl groups
BARVI_RS07975	COG1022	Amp-dependent synthetase and ligase
BARVI_RS07980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BARVI_RS07985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BARVI_RS07990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BARVI_RS08000	COG0367	asparagine synthase
BARVI_RS08010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BARVI_RS08015	COG0049	tRNA binding
BARVI_RS08020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BARVI_RS08025	COG0051	transcription antitermination factor activity, RNA binding
BARVI_RS08030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BARVI_RS08035	COG0088	Forms part of the polypeptide exit tunnel
BARVI_RS08040	COG0089	rRNA binding
BARVI_RS08045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BARVI_RS08050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BARVI_RS08055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BARVI_RS08060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BARVI_RS08065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BARVI_RS08070	COG0255	Belongs to the universal ribosomal protein uL29 family
BARVI_RS08075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BARVI_RS08080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BARVI_RS08085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BARVI_RS08090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BARVI_RS08095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BARVI_RS08100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BARVI_RS08105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BARVI_RS08110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BARVI_RS08115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BARVI_RS08120	COG1841	ribosomal large subunit assembly
BARVI_RS08125	COG0200	Binds to the 23S rRNA
BARVI_RS08135	COG0024	Methionine aminopeptidase
BARVI_RS08140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BARVI_RS08145	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BARVI_RS08150	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BARVI_RS08155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BARVI_RS08160	COG0202	RNA polymerase activity
BARVI_RS08165	COG0203	ribosomal protein L17
BARVI_RS08170	COG0148	phosphopyruvate hydratase activity
BARVI_RS08200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BARVI_RS08205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BARVI_RS08210	COG0052	Belongs to the universal ribosomal protein uS2 family
BARVI_RS08215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BARVI_RS08220	COG2205	protein histidine kinase activity
BARVI_RS08220	COG3292	Two component regulator propeller
BARVI_RS08220	COG0745	RESPONSE REGULATOR receiver
BARVI_RS08225	COG3292	Two component regulator propeller
BARVI_RS08225	COG2205	protein histidine kinase activity
BARVI_RS08225	COG0745	RESPONSE REGULATOR receiver
BARVI_RS08270	COG4206	TonB-dependent receptor
BARVI_RS08270	COG1629	transport
BARVI_RS08280	COG1472	Belongs to the glycosyl hydrolase 3 family
BARVI_RS08300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BARVI_RS08305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BARVI_RS08315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BARVI_RS08320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BARVI_RS08325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BARVI_RS08335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BARVI_RS08350	COG0393	Putative heavy-metal-binding
BARVI_RS08355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BARVI_RS08360	COG1120	ATPase activity
BARVI_RS08365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BARVI_RS08400	COG0653	protein targeting
BARVI_RS08420	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BARVI_RS08460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BARVI_RS08505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BARVI_RS08510	COG0517	IMP dehydrogenase activity
BARVI_RS08510	COG0617	tRNA 3'-terminal CCA addition
BARVI_RS08510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BARVI_RS08525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BARVI_RS08540	COG1773	rubredoxin
BARVI_RS08540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BARVI_RS08545	COG1592	Rubrerythrin
BARVI_RS08555	COG3969	phosphoadenosine phosphosulfate
BARVI_RS08560	COG1475	DNA binding
BARVI_RS08565	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BARVI_RS08570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BARVI_RS08575	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BARVI_RS08580	COG0193	aminoacyl-tRNA hydrolase activity
BARVI_RS08585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BARVI_RS08640	COG0742	ribosomal rna small subunit methyltransferase
BARVI_RS08660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BARVI_RS08695	COG1418	mRNA catabolic process
BARVI_RS08700	COG1774	PSP1 C-terminal conserved region
BARVI_RS08715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BARVI_RS08730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BARVI_RS08730	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BARVI_RS08735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BARVI_RS08740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BARVI_RS08780	COG1187	pseudouridine synthase activity
BARVI_RS08785	COG0017	Asparaginyl-tRNA synthetase
BARVI_RS08815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BARVI_RS08825	COG0101	tRNA pseudouridine synthase activity
BARVI_RS08830	COG1166	arginine decarboxylase activity
BARVI_RS08835	COG0191	fructose-bisphosphate aldolase activity
BARVI_RS08840	COG1028	Short-chain dehydrogenase reductase Sdr
BARVI_RS08870	COG0848	biopolymer transport protein
BARVI_RS08875	COG0811	peptide transport
BARVI_RS08890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BARVI_RS08900	COG1695	Transcriptional regulator
BARVI_RS08910	COG0779	Required for maturation of 30S ribosomal subunits
BARVI_RS08915	COG0195	Participates in both transcription termination and antitermination
BARVI_RS08920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BARVI_RS08930	COG0719	Fe-S assembly protein
BARVI_RS08935	COG0396	ATPase activity
BARVI_RS08940	COG0719	Fe-S assembly protein
BARVI_RS08960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BARVI_RS08965	COG0318	PFAM AMP-dependent synthetase and ligase
BARVI_RS08975	COG1785	Belongs to the alkaline phosphatase family
BARVI_RS08980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BARVI_RS08985	COG0463	Glycosyl transferase, family 2
BARVI_RS09000	COG0698	ribose 5-phosphate isomerase
BARVI_RS09025	COG2271	Major facilitator Superfamily
BARVI_RS09030	COG0247	lactate metabolic process
BARVI_RS09040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BARVI_RS09045	COG1349	DNA-binding transcription factor activity
BARVI_RS09050	COG0534	Mate efflux family protein
BARVI_RS09060	COG2217	Heavy metal translocating P-type atpase
BARVI_RS09080	COG4535	Mg2 and Co2 transporter CorC
BARVI_RS09085	COG0629	single-stranded DNA binding
BARVI_RS09095	COG3279	Response regulator of the LytR AlgR family
BARVI_RS09100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BARVI_RS09105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BARVI_RS09110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BARVI_RS09115	COG0137	argininosuccinate synthase activity
BARVI_RS09125	COG1438	arginine binding
BARVI_RS09130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BARVI_RS09135	COG1192	Involved in chromosome partitioning
BARVI_RS09140	COG1475	DNA binding
BARVI_RS09150	COG1388	LysM domain
BARVI_RS09150	COG0741	lytic transglycosylase activity
BARVI_RS09160	COG1162	GTPase activity
BARVI_RS09165	COG0233	cytoplasmic translational termination
BARVI_RS09170	COG0528	UMP kinase activity
BARVI_RS09180	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BARVI_RS09180	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BARVI_RS09185	COG0792	nuclease activity
BARVI_RS09205	COG0539	negative regulation of cytoplasmic translation
BARVI_RS09205	COG2183	response to ionizing radiation
BARVI_RS09210	COG1234	tRNA 3'-trailer cleavage
BARVI_RS09225	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BARVI_RS09240	COG0009	L-threonylcarbamoyladenylate synthase
BARVI_RS09245	COG0039	L-malate dehydrogenase activity
BARVI_RS09285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BARVI_RS09300	COG0802	atpase or kinase
BARVI_RS09305	COG2204	response regulator
BARVI_RS09315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BARVI_RS09330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BARVI_RS09335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BARVI_RS09345	COG0534	Mate efflux family protein
BARVI_RS09380	COG0335	large ribosomal subunit rRNA binding
BARVI_RS09385	COG0737	Belongs to the 5'-nucleotidase family
BARVI_RS09390	COG0737	Belongs to the 5'-nucleotidase family
BARVI_RS09395	COG1472	Belongs to the glycosyl hydrolase 3 family
BARVI_RS09415	COG2211	Major facilitator Superfamily
BARVI_RS09425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BARVI_RS09440	COG0739	heme binding
BARVI_RS09445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BARVI_RS09450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BARVI_RS09460	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BARVI_RS09465	COG2151	metal-sulfur cluster biosynthetic enzyme
BARVI_RS09475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BARVI_RS09500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BARVI_RS09515	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BARVI_RS09520	COG0540	Belongs to the ATCase OTCase family
BARVI_RS09525	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BARVI_RS09530	COG4464	protein tyrosine phosphatase activity
BARVI_RS09535	COG5016	pyruvate
BARVI_RS09535	COG0511	ligase activity, forming carbon-carbon bonds
BARVI_RS09540	COG0254	rRNA binding
BARVI_RS09545	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BARVI_RS09565	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BARVI_RS09575	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BARVI_RS09580	COG1805	sodium ion transport
BARVI_RS09585	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BARVI_RS09590	COG0811	peptide transport
BARVI_RS09630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BARVI_RS09635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BARVI_RS09640	COG0649	NAD binding
BARVI_RS09645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BARVI_RS09660	COG0356	it plays a direct role in the translocation of protons across the membrane
BARVI_RS09665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BARVI_RS09670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BARVI_RS09675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BARVI_RS09680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BARVI_RS09685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BARVI_RS09690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BARVI_RS09695	COG0839	Belongs to the complex I subunit 6 family
BARVI_RS09700	COG0713	ATP synthesis coupled electron transport
BARVI_RS09705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BARVI_RS09710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BARVI_RS09720	COG1333	cytochrome c biogenesis protein
BARVI_RS09720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BARVI_RS09735	COG1730	sister chromatid segregation
BARVI_RS09745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BARVI_RS09750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BARVI_RS09760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BARVI_RS09765	COG0280	phosphate acetyltransferase
BARVI_RS09780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BARVI_RS09780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BARVI_RS09795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BARVI_RS09815	COG0628	permease
BARVI_RS09835	COG1733	regulation of RNA biosynthetic process
BARVI_RS09900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BARVI_RS09915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BARVI_RS09920	COG1722	exodeoxyribonuclease VII activity
BARVI_RS09925	COG1570	exodeoxyribonuclease VII activity
BARVI_RS09935	COG0482	sulfurtransferase activity
BARVI_RS09940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BARVI_RS09955	COG0179	Fumarylacetoacetate (FAA) hydrolase
BARVI_RS09960	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BARVI_RS09975	COG2207	Transcriptional regulator
BARVI_RS10120	COG0358	DNA primase activity
BARVI_RS10225	COG1373	ATPase (AAA superfamily
BARVI_RS10240	COG0551	DNA topoisomerase type I activity
BARVI_RS10240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BARVI_RS10275	COG3189	MarR family transcriptional regulator
BARVI_RS10310	COG1082	Xylose isomerase domain protein TIM barrel
BARVI_RS10325	COG4771	TonB-dependent receptor
BARVI_RS10330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BARVI_RS10355	COG1472	Belongs to the glycosyl hydrolase 3 family
BARVI_RS10380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BARVI_RS10380	COG2198	Histidine kinase
BARVI_RS10380	COG2205	protein histidine kinase activity
BARVI_RS10380	COG0784	Response regulator, receiver
BARVI_RS10385	COG2204	response regulator
BARVI_RS10410	COG4974	Belongs to the 'phage' integrase family
BARVI_RS10415	COG0582	viral genome integration into host DNA
BARVI_RS10425	COG1074	ATP-dependent DNA helicase activity
BARVI_RS10430	COG0671	phosphoesterase, PA-phosphatase related
BARVI_RS10435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BARVI_RS10445	COG2003	Belongs to the UPF0758 family
BARVI_RS10460	COG2195	Cleaves the N-terminal amino acid of tripeptides
BARVI_RS10470	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BARVI_RS10485	COG4589	Belongs to the CDS family
BARVI_RS10490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BARVI_RS10495	COG0799	negative regulation of ribosome biogenesis
BARVI_RS10510	COG0686	Belongs to the AlaDH PNT family
BARVI_RS10545	COG3876	Protein conserved in bacteria
BARVI_RS10550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BARVI_RS10580	COG4771	TonB-dependent receptor
BARVI_RS10600	COG1051	belongs to the nudix hydrolase family
BARVI_RS10610	COG1566	PFAM secretion protein HlyD family protein
BARVI_RS10640	COG0667	Aldo Keto reductase
BARVI_RS10645	COG0165	Argininosuccinate lyase
BARVI_RS10655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BARVI_RS10660	COG1040	competence protein
BARVI_RS10665	COG2137	regulation of response to DNA damage stimulus
BARVI_RS10670	COG2890	protein-(glutamine-N5) methyltransferase activity
BARVI_RS10675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BARVI_RS10675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BARVI_RS10690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BARVI_RS10695	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BARVI_RS10710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BARVI_RS10715	COG1187	pseudouridine synthase activity
BARVI_RS10720	COG2855	membrane
BARVI_RS10725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BARVI_RS10735	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BARVI_RS10740	COG4974	Belongs to the 'phage' integrase family
BARVI_RS10765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BARVI_RS10785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BARVI_RS10790	COG0081	regulation of translation
BARVI_RS10795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BARVI_RS10800	COG0222	ribosome binding
BARVI_RS10805	COG0085	RNA polymerase activity
BARVI_RS10810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BARVI_RS10815	COG1121	(ABC) transporter
BARVI_RS10830	COG1522	sequence-specific DNA binding
BARVI_RS10835	COG0180	Tryptophanyl-tRNA synthetase
BARVI_RS10845	COG0758	DNA mediated transformation
BARVI_RS10845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BARVI_RS10865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BARVI_RS10880	COG2502	aspartate--ammonia ligase
BARVI_RS10900	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
BARVI_RS10905	COG1454	alcohol dehydrogenase
BARVI_RS10915	COG1070	Carbohydrate kinase
BARVI_RS10920	COG0738	Major facilitator superfamily
BARVI_RS10930	COG1566	PFAM secretion protein HlyD family protein
BARVI_RS10935	COG3275	phosphorelay sensor kinase activity
BARVI_RS10940	COG3279	Response regulator of the LytR AlgR family
BARVI_RS10950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BARVI_RS10955	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
BARVI_RS10960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
BARVI_RS11000	COG2264	protein methyltransferase activity
BARVI_RS11005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BARVI_RS11005	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BARVI_RS11015	COG0306	phosphate transporter
BARVI_RS11020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BARVI_RS11025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BARVI_RS11030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BARVI_RS11035	COG0131	Imidazoleglycerol-phosphate dehydratase
BARVI_RS11085	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BARVI_RS11095	COG2076	Multidrug Resistance protein
BARVI_RS11100	COG0564	pseudouridine synthase activity
BARVI_RS11105	COG0513	Belongs to the DEAD box helicase family
BARVI_RS11110	COG0424	maF-like protein
BARVI_RS11115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BARVI_RS11160	COG3153	acetyltransferase
BARVI_RS11160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BARVI_RS11180	COG3279	Response regulator of the LytR AlgR family
BARVI_RS11185	COG2972	Histidine kinase
BARVI_RS11190	COG0577	efflux transmembrane transporter activity
BARVI_RS11190	COG1136	(ABC) transporter
BARVI_RS11195	COG1136	(ABC) transporter
BARVI_RS11200	COG1566	PFAM secretion protein HlyD family protein
BARVI_RS11230	COG0697	spore germination
BARVI_RS11240	COG0076	glutamate decarboxylase activity
BARVI_RS11245	COG2066	Belongs to the glutaminase family
BARVI_RS11255	COG0531	amino acid
BARVI_RS11265	COG0442	prolyl-tRNA aminoacylation
BARVI_RS11275	COG0778	Nitroreductase
BARVI_RS11290	COG1408	metallophosphoesterase
BARVI_RS11300	COG0564	pseudouridine synthase activity
BARVI_RS11380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BARVI_RS11395	COG3385	transposase activity
BARVI_RS11425	COG1472	Belongs to the glycosyl hydrolase 3 family
BARVI_RS11430	COG1082	Xylose isomerase domain protein TIM barrel
BARVI_RS11445	COG4206	TonB-dependent receptor
BARVI_RS11445	COG1629	transport
BARVI_RS11485	COG4948	Mandelate Racemase Muconate Lactonizing
BARVI_RS11510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BARVI_RS11540	COG1501	Belongs to the glycosyl hydrolase 31 family
BARVI_RS11670	COG0598	Magnesium transport protein CorA
BARVI_RS11950	COG0358	DNA primase activity
BARVI_RS12000	COG3344	reverse transcriptase
BARVI_RS12095	COG2198	Histidine kinase
BARVI_RS12095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BARVI_RS12095	COG2205	protein histidine kinase activity
BARVI_RS12095	COG0784	Response regulator, receiver
BARVI_RS12115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BARVI_RS12115	COG0551	DNA topoisomerase type I activity
BARVI_RS12150	COG4974	Belongs to the 'phage' integrase family
BARVI_RS12175	COG0326	Molecular chaperone. Has ATPase activity
BARVI_RS12200	COG4974	Belongs to the 'phage' integrase family
BARVI_RS12205	COG4974	Belongs to the 'phage' integrase family
BARVI_RS12275	COG1196	nuclear chromosome segregation
BARVI_RS12290	COG2865	translation initiation factor activity
BARVI_RS12305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BARVI_RS12315	COG2195	Cleaves the N-terminal amino acid of tripeptides
BARVI_RS12320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BARVI_RS12325	COG2843	Capsule synthesis protein
BARVI_RS12330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BARVI_RS12335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BARVI_RS12340	COG0534	Mate efflux family protein
BARVI_RS12345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BARVI_RS12350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BARVI_RS12355	COG0297	glycogen (starch) synthase activity
BARVI_RS12395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BARVI_RS12395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BARVI_RS12405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BARVI_RS12410	COG1546	Belongs to the CinA family
BARVI_RS12410	COG1058	Belongs to the CinA family
BARVI_RS12415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BARVI_RS12420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BARVI_RS12425	COG0552	protein localization to endoplasmic reticulum
BARVI_RS12430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BARVI_RS12435	COG1169	isochorismate synthase
BARVI_RS12440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BARVI_RS12445	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BARVI_RS12460	COG1472	Belongs to the glycosyl hydrolase 3 family
BARVI_RS12465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BARVI_RS12470	COG0492	ferredoxin-NADP+ reductase activity
BARVI_RS12480	COG1674	ftsk spoiiie
BARVI_RS12490	COG0569	domain protein
BARVI_RS12495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BARVI_RS12510	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BARVI_RS12515	COG0436	Aminotransferase
BARVI_RS12520	COG0077	Prephenate dehydratase
BARVI_RS12520	COG1605	Chorismate mutase
BARVI_RS12530	COG0544	peptidyl-prolyl cis-trans isomerase activity
BARVI_RS12535	COG0740	serine-type endopeptidase activity
BARVI_RS12540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BARVI_RS12550	COG0516	GMP reductase activity
BARVI_RS12550	COG0517	IMP dehydrogenase activity
BARVI_RS12555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BARVI_RS12565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BARVI_RS12575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BARVI_RS12580	COG3022	response to hydroperoxide
BARVI_RS12605	COG4771	TonB-dependent receptor
BARVI_RS12610	COG0702	epimerase
BARVI_RS12620	COG5297	Belongs to the glycosyl hydrolase family 6
BARVI_RS12630	COG1082	Xylose isomerase domain protein TIM barrel
BARVI_RS12650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BARVI_RS12660	COG1538	Outer membrane efflux protein
BARVI_RS12665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BARVI_RS12685	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BARVI_RS12690	COG0390	transport system, permease component
BARVI_RS12695	COG1126	abc transporter atp-binding protein
BARVI_RS12700	COG0823	Involved in the tonB-independent uptake of proteins
BARVI_RS12700	COG1506	peptidase
BARVI_RS12705	COG1032	radical SAM domain protein
BARVI_RS12710	COG0556	nucleotide-excision repair
BARVI_RS12730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BARVI_RS12745	COG0237	dephospho-CoA kinase activity
BARVI_RS12755	COG2333	competence protein COMEC
BARVI_RS12755	COG0658	competence protein
BARVI_RS12760	COG0583	DNA-binding transcription factor activity
BARVI_RS12775	COG0860	N-Acetylmuramoyl-L-alanine amidase
BARVI_RS12805	COG0438	transferase activity, transferring glycosyl groups
BARVI_RS12885	COG1442	glycosyl transferase family 8
BARVI_RS12885	COG1216	Glycosyl transferase, family 2
BARVI_RS12910	COG0545	Peptidyl-prolyl cis-trans isomerase
BARVI_RS12925	COG2207	Transcriptional regulator
BARVI_RS12950	COG4977	sequence-specific DNA binding
BARVI_RS12950	COG1917	Cupin 2, conserved barrel domain protein
BARVI_RS12965	COG1309	transcriptional regulator
BARVI_RS12980	COG1216	Glycosyl transferase, family 2
BARVI_RS12985	COG0463	Glycosyl transferase, family 2
BARVI_RS13000	COG4977	sequence-specific DNA binding
BARVI_RS13015	COG0584	glycerophosphoryl diester phosphodiesterase
BARVI_RS13045	COG2356	endonuclease I