locus-tag	class	description
HWV54_RS00005	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HWV54_RS00010	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HWV54_RS00015	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HWV54_RS00025	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HWV54_RS00030	ENOG4107XZX	Involved in the transcription termination process (By similarity)
HWV54_RS00045	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HWV54_RS00050	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HWV54_RS00055	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HWV54_RS00060	ENOG4105WJX	transcriptional regulator MERR family
HWV54_RS00065	ENOG4105C22	threonyL-tRNA synthetase
HWV54_RS00070	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HWV54_RS00080	ENOG4105EUJ	GTP cyclohydrolase i
HWV54_RS00105	ENOG4105EJQ	L-serine dehydratase
HWV54_RS00115	ENOG4105DZ1	carboxypeptidase
HWV54_RS00130	ENOG4105K59	histidine triad (HIT) protein
HWV54_RS00145	ENOG4105CE9	30S ribosomal protein S2
HWV54_RS00150	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HWV54_RS00155	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HWV54_RS00160	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HWV54_RS00170	ENOG4105DZP	Membrane-associated zinc metalloprotease
HWV54_RS00175	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWV54_RS00180	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HWV54_RS00185	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HWV54_RS00190	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HWV54_RS00200	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HWV54_RS00205	ENOG4105CDA	abc transporter atp-binding protein
HWV54_RS00215	ENOG4105GBT	ABC transporter
HWV54_RS00220	ENOG4106PMH	Extracellular solute-binding protein family 3
HWV54_RS00225	ENOG4106PMH	Extracellular solute-binding protein family 3
HWV54_RS00230	ENOG4105BZN	citrate synthase
HWV54_RS00235	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HWV54_RS00240	ENOG4108EC8	DNA internalization-related competence protein ComEC
HWV54_RS00245	ENOG4105E66	phosphoriboisomerase A
HWV54_RS00260	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
HWV54_RS00265	ENOG4105C4K	Nad synthetase
HWV54_RS00270	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HWV54_RS00275	ENOG4105C1J	atp-dependent rna helicase
HWV54_RS00290	ENOG4105C84	Histidine ammonia-lyase
HWV54_RS00300	ENOG4105C85	amino acid
HWV54_RS00325	ENOG4105MZU	cell filamentation protein
HWV54_RS00345	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HWV54_RS00350	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWV54_RS00355	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HWV54_RS00360	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWV54_RS00365	ENOG4105GKE	subunit e
HWV54_RS00370	ENOG4107QIZ	NADH dehydrogenase
HWV54_RS00375	ENOG4107R0R	NADH dehydrogenase subunit g
HWV54_RS00380	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HWV54_RS00385	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWV54_RS00390	ENOG4105DF2	NADH dehydrogenase subunit j
HWV54_RS00395	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWV54_RS00400	ENOG4105D65	subunit l
HWV54_RS00405	ENOG4105C8S	subunit m
HWV54_RS00410	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWV54_RS00425	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HWV54_RS00435	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HWV54_RS00440	ENOG4107NKQ	Flavinator of succinate dehydrogenase
HWV54_RS00455	ENOG4105C03	ribonuclease
HWV54_RS00460	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HWV54_RS00475	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWV54_RS00480	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HWV54_RS00485	ENOG4105DHZ	alpha beta
HWV54_RS00500	ENOG4105C3K	feS assembly ATPase SufC
HWV54_RS00505	ENOG4105JRK	feS assembly protein SufD
HWV54_RS00520	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HWV54_RS00535	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HWV54_RS00540	ENOG4105VE1	Phosphatidylcholine synthase
HWV54_RS00555	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HWV54_RS00560	ENOG4105F8V	Hydrolase, tatD family
HWV54_RS00565	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HWV54_RS00570	ENOG4107QRG	dna polymerase iii
HWV54_RS00575	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HWV54_RS00580	ENOG4105DZ1	carboxypeptidase
HWV54_RS00615	ENOG4105C02	permease
HWV54_RS00620	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HWV54_RS00625	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HWV54_RS00645	ENOG4105DJV	ribulose-phosphate 3-epimerase
HWV54_RS00650	ENOG4105C83	adenylosuccinate lyase
HWV54_RS00660	ENOG4107QPR	SAICAR synthetase
HWV54_RS00670	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HWV54_RS00675	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
HWV54_RS00685	ENOG4105M2J	Glutaredoxin
HWV54_RS00690	ENOG4105C2C	drug resistance transporter, Bcr CflA
HWV54_RS00695	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HWV54_RS00700	ENOG4105C9M	aspartyl-trna synthetase
HWV54_RS00705	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HWV54_RS00710	ENOG4105C9X	ppx gppa phosphatase
HWV54_RS00715	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HWV54_RS00725	ENOG4105MSY	salicylate hydroxylase
HWV54_RS00735	ENOG4105CB5	ATP-dependent DNA helicase recG
HWV54_RS00740	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HWV54_RS00745	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HWV54_RS00750	ENOG4107QIV	Cytochrome c biogenesis protein
HWV54_RS00760	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HWV54_RS00765	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HWV54_RS00770	ENOG4105C75	arginyL-tRNA synthetase
HWV54_RS00785	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HWV54_RS00795	ENOG4105D6E	homoserine dehydrogenase
HWV54_RS00815	ENOG4105F27	Major Facilitator
HWV54_RS00820	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HWV54_RS00835	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HWV54_RS00855	ENOG4108YZA	Nitrogen regulatory protein pii
HWV54_RS00860	ENOG4105C5F	glutamine synthetase
HWV54_RS00875	ENOG4105EI2	Pseudouridine synthase
HWV54_RS00885	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HWV54_RS00890	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HWV54_RS00895	ENOG4105D1H	recombination factor protein RarA
HWV54_RS00900	ENOG4105C0H	protease
HWV54_RS00905	ENOG4108ZT0	50S ribosomal protein l17
HWV54_RS00910	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HWV54_RS00915	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HWV54_RS00920	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HWV54_RS00925	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HWV54_RS00935	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HWV54_RS00940	ENOG41084HQ	50S ribosomal protein L30
HWV54_RS00945	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HWV54_RS00950	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HWV54_RS00955	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HWV54_RS00960	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HWV54_RS00965	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HWV54_RS00970	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HWV54_RS00975	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HWV54_RS00985	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HWV54_RS00990	ENOG41083MP	50s ribosomal protein l29
HWV54_RS00995	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HWV54_RS01000	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HWV54_RS01005	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HWV54_RS01010	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HWV54_RS01015	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HWV54_RS01020	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HWV54_RS01025	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HWV54_RS01030	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HWV54_RS01035	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HWV54_RS01040	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HWV54_RS01045	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HWV54_RS01050	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HWV54_RS01055	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HWV54_RS01060	ENOG4105CGK	Exodeoxyribonuclease III
HWV54_RS01065	ENOG4107RP9	extracellular solute-binding protein, family 3
HWV54_RS01070	ENOG4105EAD	ABC transporter
HWV54_RS01075	ENOG4105DRP	amino acid AbC transporter
HWV54_RS01080	ENOG4105CDA	abc transporter atp-binding protein
HWV54_RS01085	ENOG4108P7N	Exopolysaccharide production negative regulator
HWV54_RS01090	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HWV54_RS01105	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HWV54_RS01120	ENOG4105C1J	atp-dependent rna helicase
HWV54_RS01125	ENOG4105C7B	Threonine dehydratase
HWV54_RS01135	ENOG4105JVC	membrAne
HWV54_RS01145	ENOG4105EGS	Mechanosensitive ion channel
HWV54_RS01160	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HWV54_RS01170	ENOG4105EE5	Membrane protein terC
HWV54_RS01220	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HWV54_RS01225	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HWV54_RS01230	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HWV54_RS01235	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HWV54_RS01240	ENOG4108UJD	30S ribosomal protein S9
HWV54_RS01245	ENOG4108UXN	response regulator
HWV54_RS01260	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HWV54_RS01270	ENOG4107SID	ATP-dependent exodnase (exonuclease v)
HWV54_RS01275	ENOG4105C7K	acetolactate synthase
HWV54_RS01280	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HWV54_RS01285	ENOG4105C0H	protease
HWV54_RS01305	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HWV54_RS01310	ENOG4105CSH	Transporter
HWV54_RS01315	ENOG4105CSH	Transporter
HWV54_RS01320	ENOG4105CSH	Transporter
HWV54_RS01370	ENOG4105DC7	peptidase M24
HWV54_RS01375	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HWV54_RS01380	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HWV54_RS01385	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWV54_RS01395	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HWV54_RS01400	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HWV54_RS01405	ENOG4108UFP	Essential cell division protein (By similarity)
HWV54_RS01410	ENOG4105CPF	Cell wall formation (By similarity)
HWV54_RS01415	ENOG4105D4A	Cell wall formation (By similarity)
HWV54_RS01420	ENOG4105DFU	Cell wall formation (By similarity)
HWV54_RS01425	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HWV54_RS01435	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HWV54_RS01440	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HWV54_RS01465	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HWV54_RS01475	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HWV54_RS01495	ENOG4108RWI	nicotinamidase
HWV54_RS01520	ENOG4105MPN	Membrane
HWV54_RS01530	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HWV54_RS01535	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HWV54_RS01540	ENOG4105CUY	Mechanosensitive ion channel
HWV54_RS01545	ENOG4105EAM	Na Pi-cotransporter
HWV54_RS01555	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HWV54_RS01560	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HWV54_RS01590	ENOG4105CBN	LysR family transcriptional regulator
HWV54_RS01595	ENOG4105C3M	thioredoxin reductase
HWV54_RS01600	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HWV54_RS01610	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HWV54_RS01620	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HWV54_RS01630	ENOG4105C5X	domain protein
HWV54_RS01635	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HWV54_RS01655	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HWV54_RS01680	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HWV54_RS01685	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HWV54_RS01690	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HWV54_RS01695	ENOG4105C3G	gtp-binding protein
HWV54_RS01720	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HWV54_RS01725	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HWV54_RS01730	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HWV54_RS01765	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HWV54_RS01800	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HWV54_RS01825	ENOG4108JQ7	(ABC) transporter
HWV54_RS01830	ENOG4105C3U	ABC transporter
HWV54_RS01835	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HWV54_RS01840	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HWV54_RS01845	ENOG4105DEF	Extracellular solute-binding protein, family 5
HWV54_RS01855	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HWV54_RS01860	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HWV54_RS01865	ENOG4105DEF	Extracellular solute-binding protein, family 5
HWV54_RS01885	ENOG4108VCT	Sulfite exporter TauE/SafE
HWV54_RS01895	ENOG4105BZJ	Electron transfer flavoprotein
HWV54_RS01900	ENOG4105C10	Electron transfer flavoprotein
HWV54_RS01910	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HWV54_RS01925	ENOG41082FP	UPF0102 protein
HWV54_RS01930	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HWV54_RS01945	ENOG4105KK3	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HWV54_RS01955	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HWV54_RS01965	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HWV54_RS01970	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HWV54_RS01995	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HWV54_RS02005	ENOG4105CZQ	inner membrane transport protein YdhC
HWV54_RS02070	ENOG4105C72	UPF0176 protein
HWV54_RS02080	ENOG4105DP0	ferredoxin-NADP reductase
HWV54_RS02090	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWV54_RS02095	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HWV54_RS02100	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HWV54_RS02105	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HWV54_RS02110	ENOG4105W49	UPF0434 protein
HWV54_RS02115	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HWV54_RS02125	ENOG4105D01	(LipO)protein
HWV54_RS02130	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HWV54_RS02135	ENOG4108UMI	ABC transporter, permease
HWV54_RS02160	ENOG4105CKI	cobalamin synthesis protein
HWV54_RS02195	ENOG4105DHS	permease protein
HWV54_RS02200	ENOG4105CM4	permease protein
HWV54_RS02205	ENOG4108IPW	abc transporter atp-binding protein
HWV54_RS02270	ENOG4107QJE	Chromosome Partitioning Protein
HWV54_RS02280	ENOG4105DTN	riboflavin biosynthesis protein ribF
HWV54_RS02350	ENOG4105CMA	conjugation trbi family protein
HWV54_RS02355	ENOG4108EHY	type IV secretion system
HWV54_RS02565	ENOG4108V42	Type IV secretion system protein VirB8
HWV54_RS02575	ENOG4105CMA	conjugation trbi family protein
HWV54_RS02580	ENOG4108EHY	type IV secretion system
HWV54_RS02590	ENOG4105MZU	cell filamentation protein
HWV54_RS02595	ENOG4105E80	TraG TraD family protein
HWV54_RS02600	ENOG4105MZU	cell filamentation protein
HWV54_RS02620	ENOG4105MZU	cell filamentation protein
HWV54_RS02625	ENOG4105CJR	Integral membrane protein (MviN
HWV54_RS02630	ENOG4105C31	Tryptophanyl-tRNA synthetase
HWV54_RS02640	ENOG41083MR	nifu domain-containing protein
HWV54_RS02645	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HWV54_RS02650	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HWV54_RS02655	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HWV54_RS02665	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HWV54_RS02680	ENOG4105CUT	histidyl-tRNA synthetase
HWV54_RS02695	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HWV54_RS02745	ENOG4105RAK	Histidine kinase
HWV54_RS02760	ENOG41074H6	response regulator
HWV54_RS02855	ENOG41086Q3	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
HWV54_RS02860	ENOG4108Z03	MAF-like protein
HWV54_RS02865	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HWV54_RS02875	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HWV54_RS02880	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HWV54_RS02890	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HWV54_RS02900	ENOG4105YK5	50S ribosomal protein L36
HWV54_RS02905	ENOG4105M0T	TPR Repeat-Containing Protein
HWV54_RS02930	ENOG4105D48	metallophosphoesterase
HWV54_RS02935	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HWV54_RS03025	ENOG4108UM1	dedA family
HWV54_RS03040	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HWV54_RS03060	ENOG4108ZZF	transport protein (ExbD)
HWV54_RS03065	ENOG4105CWK	Biopolymer transport protein, ExbB
HWV54_RS03080	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HWV54_RS03085	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HWV54_RS03090	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HWV54_RS03100	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HWV54_RS03110	ENOG4105CDY	transcriptional regulatory protein
HWV54_RS03115	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HWV54_RS03125	ENOG4105SG9	biopolymer transport protein, ExbD
HWV54_RS03130	ENOG4105E02	MotA TolQ exbB proton channel
HWV54_RS03135	ENOG4107YD3	Thioesterase
HWV54_RS03140	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HWV54_RS03145	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HWV54_RS03150	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HWV54_RS03175	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HWV54_RS03180	ENOG4105ECY	inositol monophosphatase
HWV54_RS03185	ENOG4105BZ1	(ABC) transporter
HWV54_RS03190	ENOG41082FS	50S ribosomal protein L31
HWV54_RS03195	ENOG4107R1Y	fructose-bisphosphate aldolase
HWV54_RS03200	ENOG4105BZA	Phosphoglycerate kinase
HWV54_RS03225	ENOG4105CA9	Pyruvate kinase
HWV54_RS03235	ENOG4105Y2X	UPF0335 protein
HWV54_RS03240	ENOG4105C5H	ABC transporter
HWV54_RS03255	ENOG4105ERG	peptidase m48, ste24p
HWV54_RS03260	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HWV54_RS03270	ENOG4108Z4U	Ferredoxin
HWV54_RS03280	ENOG41082R8	50S ribosomal protein l32
HWV54_RS03285	ENOG4105CTB	Polyprenyl synthetase
HWV54_RS03310	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HWV54_RS03320	ENOG4105CW7	secretion protein, HlyD family
HWV54_RS03330	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HWV54_RS03335	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HWV54_RS03340	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HWV54_RS03345	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HWV54_RS03350	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HWV54_RS03355	ENOG4105C25	Primosomal protein n'
HWV54_RS03360	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HWV54_RS03370	ENOG4105C8T	Leucyl-tRNA synthetase
HWV54_RS03375	ENOG4105DFA	alanine racemase domain protein
HWV54_RS03380	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HWV54_RS03385	ENOG4105CAK	Cell division ATP-binding protein ftsE
HWV54_RS03400	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HWV54_RS03405	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HWV54_RS03425	ENOG4105CNU	cell division protein FtsK
HWV54_RS03510	ENOG4105CMA	conjugation trbi family protein
HWV54_RS03520	ENOG4105E33	succinate dehydrogenase
HWV54_RS03525	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HWV54_RS03540	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HWV54_RS03545	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HWV54_RS03550	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HWV54_RS03590	ENOG4105KDC	50s ribosomal protein l28
HWV54_RS03600	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HWV54_RS03610	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HWV54_RS03615	ENOG4105D0M	Protease HtpX homolog
HWV54_RS03625	ENOG4105K5M	30s ribosomal protein S16
HWV54_RS03640	ENOG4107B2H	carbonic anhydrase
HWV54_RS03645	ENOG4105C7I	Dehydrogenase
HWV54_RS03655	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HWV54_RS03670	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HWV54_RS03685	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HWV54_RS03690	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HWV54_RS03740	ENOG4107T0D	ABC, transporter
HWV54_RS03760	ENOG4105DWF	phosphomethylpyrimidine kinase
HWV54_RS03770	ENOG4105DZ1	carboxypeptidase
HWV54_RS03775	ENOG4105CKI	cobalamin synthesis protein
HWV54_RS03780	ENOG4105F7V	ErfK ybiS ycfS ynhG family protein
HWV54_RS03785	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HWV54_RS03800	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HWV54_RS03805	ENOG4105D49	3-dehydroquinate synthase
HWV54_RS03815	ENOG41069B0	Membrane-bound lysozyme-inhibitor of c-type lysozyme
HWV54_RS03820	ENOG4105KJM	monovalent cation h antiporter subunit g
HWV54_RS03825	ENOG4105W4C	monovalent cation H antiporter subunit F
HWV54_RS03830	ENOG4105SC1	monovalent cation H antiporter subunit E
HWV54_RS03835	ENOG4107R4Z	monovalent cation h antiporter subunit d
HWV54_RS03840	ENOG4108ZE9	Monovalent cation H antiporter subunit C
HWV54_RS03845	ENOG4105D65	subunit l
HWV54_RS03850	ENOG4105W6J	BA14K family
HWV54_RS03855	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
HWV54_RS03865	ENOG4107QN2	dihydrolipoyl dehydrogenase
HWV54_RS03870	ENOG4105C7S	Dehydrogenase
HWV54_RS03875	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HWV54_RS03885	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HWV54_RS03890	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HWV54_RS03895	ENOG4105D6Z	AFG1 family ATPase
HWV54_RS03900	ENOG4105UXD	Outer membrane lipoprotein
HWV54_RS03905	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HWV54_RS03910	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HWV54_RS03915	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HWV54_RS03925	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HWV54_RS03940	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
HWV54_RS03945	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HWV54_RS03950	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HWV54_RS03955	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HWV54_RS03960	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HWV54_RS03965	ENOG4108UHJ	MAF-like protein
HWV54_RS03970	ENOG4105E2X	shikimate dehydrogenase
HWV54_RS03975	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HWV54_RS03985	ENOG4105C2M	dna polymerase I
HWV54_RS03995	ENOG4105HFZ	Membrane
HWV54_RS04000	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HWV54_RS04010	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HWV54_RS04020	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HWV54_RS04030	ENOG4105RF0	OstA family
HWV54_RS04035	ENOG4108IUZ	ABC transporter
HWV54_RS04040	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HWV54_RS04050	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HWV54_RS04070	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HWV54_RS04080	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HWV54_RS04095	ENOG4105I8F	Histidine kinase
HWV54_RS04100	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HWV54_RS04105	ENOG4105CGD	Nad-dependent epimerase dehydratase
HWV54_RS04110	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HWV54_RS04115	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HWV54_RS04125	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HWV54_RS04130	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HWV54_RS04135	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HWV54_RS04150	ENOG4105C0P	Mg chelatase subunit ChlI
HWV54_RS04170	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HWV54_RS04185	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HWV54_RS04190	ENOG4105CSA	Coproporphyrinogen iii oxidase
HWV54_RS04195	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HWV54_RS04200	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HWV54_RS04205	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HWV54_RS04220	ENOG4105DAS	pts system
HWV54_RS04225	ENOG4105C3K	feS assembly ATPase SufC
HWV54_RS04230	ENOG4105EB3	Histidine kinase
HWV54_RS04235	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HWV54_RS04240	ENOG4109066	lysm domain bon superfamily protein
HWV54_RS04250	ENOG4105CFG	Acts as a chaperone (By similarity)
HWV54_RS04255	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HWV54_RS04260	ENOG4105CAS	nag kinase
HWV54_RS04270	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HWV54_RS04275	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HWV54_RS04285	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HWV54_RS04290	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HWV54_RS04295	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HWV54_RS04300	ENOG4105CGY	Dna recombination protein
HWV54_RS04325	ENOG41082BR	50S ribosomal protein L35
HWV54_RS04330	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HWV54_RS04335	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HWV54_RS04340	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HWV54_RS04350	ENOG4105DIK	(ABC) transporter
HWV54_RS04355	ENOG4105CC5	ABC transporter
HWV54_RS04360	ENOG4105CC5	ABC transporter
HWV54_RS04365	ENOG4105WD1	Membrane
HWV54_RS04370	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HWV54_RS04380	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HWV54_RS04385	ENOG4105CAT	Cytidine monophosphate kinase
HWV54_RS04390	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HWV54_RS04405	ENOG4105C01	Dihydroxy-acid dehydratase
HWV54_RS04410	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HWV54_RS04415	ENOG4105C6K	Malic enzyme
HWV54_RS04420	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HWV54_RS04425	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HWV54_RS04445	ENOG4105C8Y	Acetylornithine aminotransferase
HWV54_RS04455	ENOG4107QX9	Thiol disulfide interChange protein
HWV54_RS04460	ENOG41060IM	Heme exporter protein
HWV54_RS04465	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HWV54_RS04470	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HWV54_RS04475	ENOG4107QM5	aconitate hydratase
HWV54_RS04480	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HWV54_RS04485	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HWV54_RS04500	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HWV54_RS04505	ENOG4105E2S	oxidase) subunit II
HWV54_RS04510	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HWV54_RS04515	ENOG4105CCU	oxidase (Subunit III)
HWV54_RS04525	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HWV54_RS04530	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HWV54_RS04540	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HWV54_RS04555	ENOG4105K5G	30S ribosomal protein S21
HWV54_RS04560	ENOG4105CKU	formyltetrahydrofolate synthetase
HWV54_RS04575	ENOG4105BZS	acriflavin resistance protein
HWV54_RS04580	ENOG4107QP8	phosphohexose isomerase
HWV54_RS04590	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HWV54_RS04600	ENOG4105K46	50S ribosomal protein l27
HWV54_RS04605	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HWV54_RS04655	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HWV54_RS04660	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HWV54_RS04665	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HWV54_RS04670	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HWV54_RS04675	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HWV54_RS04685	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HWV54_RS04695	ENOG4105CN1	protease
HWV54_RS04700	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HWV54_RS04705	ENOG4105PS1	invasion associated locus B
HWV54_RS04715	ENOG410856B	UPF0235 protein
HWV54_RS04720	ENOG4105F0N	pyrophosphate phospho-hydrolase
HWV54_RS04725	ENOG4105CI3	gtp-binding protein typa
HWV54_RS04730	ENOG4105CJW	magnesium transporter
HWV54_RS04735	ENOG4105DGW	oligopeptidase A
HWV54_RS04745	ENOG4105CVE	Lytic murein transglycosylase
HWV54_RS04755	ENOG4105C2X	Arabinose 5-phosphate isomerase
HWV54_RS04760	ENOG4105ZWB	Outer membrane lipoprotein
HWV54_RS04765	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWV54_RS04770	ENOG4107RZC	phospholipase d
HWV54_RS04785	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HWV54_RS04790	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HWV54_RS04800	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HWV54_RS04820	ENOG4105DSE	periplasmic solute binding protein
HWV54_RS04825	ENOG4105CC5	ABC transporter
HWV54_RS04840	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
HWV54_RS04845	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HWV54_RS04855	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HWV54_RS04860	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HWV54_RS04870	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HWV54_RS04880	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HWV54_RS04895	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HWV54_RS04900	ENOG4105CS9	pantothenic acid kinase
HWV54_RS04905	ENOG4105HDK	L-asparaginase
HWV54_RS04910	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HWV54_RS04915	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HWV54_RS04920	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HWV54_RS04925	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HWV54_RS04930	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HWV54_RS04940	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HWV54_RS04945	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HWV54_RS04950	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HWV54_RS04960	ENOG4105CHV	Transcription elongation factor NusA
HWV54_RS04965	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HWV54_RS04970	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HWV54_RS04975	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HWV54_RS04980	ENOG4108WRK	Transcriptional regulator
HWV54_RS04990	ENOG4108JU5	Magnesium and cobalt efflux protein
HWV54_RS04995	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HWV54_RS05000	ENOG4105C9A	Phoh family
HWV54_RS05005	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HWV54_RS05015	ENOG41072GX	Peptidase M22 Glycoprotease
HWV54_RS05020	ENOG4105HMI	Membrane
HWV54_RS05025	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HWV54_RS05030	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HWV54_RS05035	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HWV54_RS05045	ENOG4105CQC	Prephenate dehydratase
HWV54_RS05050	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HWV54_RS05055	ENOG4105G9V	cytochrome C
HWV54_RS05060	ENOG4105D06	uba thif-type nad fad binding protein
HWV54_RS05075	ENOG4105D7Z	glutathione synthase
HWV54_RS05085	ENOG4105C8U	phosphate abc transporter
HWV54_RS05095	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HWV54_RS05100	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HWV54_RS05110	ENOG4105C88	aminopeptidase
HWV54_RS05115	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HWV54_RS05135	ENOG4108JBU	Outer membrane protein Omp31
HWV54_RS05140	ENOG4105JVC	membrAne
HWV54_RS05145	ENOG4105JVC	membrAne
HWV54_RS05150	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HWV54_RS05160	ENOG4108Z6B	deaminase
HWV54_RS05170	ENOG4106H78	methyltransferase
HWV54_RS05180	ENOG4105DMF	Dehydrogenase
HWV54_RS05185	ENOG4105DHP	deoxycytidine triphosphate deaminase
HWV54_RS05190	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HWV54_RS05200	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HWV54_RS05205	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HWV54_RS05215	ENOG4107TK4	histidinol-phosphate phosphatase
HWV54_RS05220	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HWV54_RS05245	ENOG4105C85	amino acid
HWV54_RS05250	ENOG4108JJB	ABC transporter
HWV54_RS05260	ENOG4107ZYJ	bioY protein
HWV54_RS05275	ENOG4105CHM	Aminotransferase
HWV54_RS05290	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HWV54_RS05295	ENOG4108IUW	ABC transporter
HWV54_RS05350	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HWV54_RS05360	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HWV54_RS05385	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HWV54_RS05390	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HWV54_RS05405	ENOG4105CJP	fad dependent oxidoreductase
HWV54_RS05410	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HWV54_RS05415	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HWV54_RS05425	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HWV54_RS05445	ENOG4105D1K	glutamate--cysteine ligase
HWV54_RS05455	ENOG4108ETY	sodium dicarboxylate symporter
HWV54_RS05465	ENOG41081UC	Inherit from COG: Competence protein
HWV54_RS05470	ENOG4105VW4	glutaredoxin 3
HWV54_RS05475	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HWV54_RS05480	ENOG4105CFH	Aspartokinase
HWV54_RS05485	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HWV54_RS05505	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HWV54_RS05515	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HWV54_RS05520	ENOG4105VD1	ATP synthase subunit C
HWV54_RS05525	ENOG4108VHN	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HWV54_RS05535	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HWV54_RS05550	ENOG4105EAH	synthase
HWV54_RS05555	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HWV54_RS05565	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HWV54_RS05570	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HWV54_RS05575	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HWV54_RS05580	ENOG4105CQB	FAD linked oxidase domain protein
HWV54_RS05595	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HWV54_RS05600	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HWV54_RS05605	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HWV54_RS05610	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HWV54_RS05615	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HWV54_RS05620	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HWV54_RS05625	ENOG41083BM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HWV54_RS05630	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HWV54_RS05645	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HWV54_RS05655	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HWV54_RS05660	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HWV54_RS05665	ENOG4105CUV	Homoserine Kinase
HWV54_RS05670	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HWV54_RS05680	ENOG4108UJU	UPF0301 protein
HWV54_RS05690	ENOG4105C1V	Peptidase, M16
HWV54_RS05695	ENOG4105D98	threonine synthase
HWV54_RS05725	ENOG4105CEC	DNA methylase N-4 N-6
HWV54_RS05730	ENOG4105CEN	a g-specific adenine glycosylase
HWV54_RS05740	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HWV54_RS05745	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HWV54_RS05760	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HWV54_RS05765	ENOG4108YXV	Transcriptional regulator
HWV54_RS05775	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HWV54_RS05805	ENOG4108JQC	penicillin-binding protein 1A
HWV54_RS05815	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HWV54_RS05820	ENOG4105BZU	Histidine kinase
HWV54_RS05830	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HWV54_RS05835	ENOG4105DA4	cytochrome c-type biogenesis protein
HWV54_RS05840	ENOG4105KWW	Biogenesis protein
HWV54_RS05845	ENOG4105C0H	protease
HWV54_RS05850	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HWV54_RS05855	ENOG4105GR3	Histidine kinase
HWV54_RS05865	ENOG4105JVC	membrAne
HWV54_RS05870	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HWV54_RS05875	ENOG4105BZU	Histidine kinase
HWV54_RS05880	ENOG4105CD8	aminopeptidase N
HWV54_RS05890	ENOG4105DWF	phosphomethylpyrimidine kinase
HWV54_RS05900	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HWV54_RS05915	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HWV54_RS05925	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HWV54_RS05930	ENOG4105EHG	Permease protein
HWV54_RS05935	ENOG4107R4I	Periplasmic binding protein
HWV54_RS05940	ENOG4106QJH	hemin transport protein
HWV54_RS05955	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HWV54_RS05960	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HWV54_RS05965	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HWV54_RS05970	ENOG4105E50	uracil-dna glycosylase
HWV54_RS05975	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HWV54_RS05980	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HWV54_RS05985	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HWV54_RS05995	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HWV54_RS06000	ENOG4105C3F	Signal peptidase i
HWV54_RS06005	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HWV54_RS06015	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
HWV54_RS06020	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HWV54_RS06025	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HWV54_RS06030	ENOG4108R7K	Metal Dependent Phosphohydrolase
HWV54_RS06035	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HWV54_RS06040	ENOG4105CD3	dihydroorotase
HWV54_RS06050	ENOG4105C8N	cysteinyl-tRNA synthetase
HWV54_RS06060	ENOG4108JJ7	ABC transporter
HWV54_RS06065	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HWV54_RS06070	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HWV54_RS06075	ENOG4105UBK	short-chain dehydrogenase reductase
HWV54_RS06080	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HWV54_RS06095	ENOG4105CDU	Replicative dna helicase
HWV54_RS06100	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HWV54_RS06110	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HWV54_RS06115	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HWV54_RS06120	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
HWV54_RS06125	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HWV54_RS06135	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HWV54_RS06140	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HWV54_RS06145	ENOG4105HHA	aminodeoxychorismate lyase
HWV54_RS06150	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HWV54_RS06155	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HWV54_RS06160	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HWV54_RS06170	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HWV54_RS06195	ENOG4105CSH	Transporter
HWV54_RS06210	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HWV54_RS06220	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HWV54_RS06225	ENOG4105D6S	protein involved in catabolism of external DNA
HWV54_RS06240	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HWV54_RS06245	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HWV54_RS06250	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HWV54_RS06255	ENOG4108K5P	(LipO)protein
HWV54_RS06260	ENOG4105VIE	preprotein translocase, subunit YajC
HWV54_RS06280	ENOG4105CP7	Triose-phosphate isomerase
HWV54_RS06285	ENOG4105NTZ	Preprotein translocase subunit SecG
HWV54_RS06290	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HWV54_RS06295	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HWV54_RS06300	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HWV54_RS06315	ENOG4108JYK	Dehydrogenase
HWV54_RS06320	ENOG4105CPP	Dehydrogenase, E1 component
HWV54_RS06325	ENOG4105C7S	Dehydrogenase
HWV54_RS06330	ENOG4107QN2	dihydrolipoyl dehydrogenase
HWV54_RS06335	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HWV54_RS06340	ENOG4108Z1B	Cyclase dehydrase
HWV54_RS06345	ENOG4105CEV	competence damage-inducible protein
HWV54_RS06350	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HWV54_RS06355	ENOG4105KPV	Transcriptional regulator
HWV54_RS06360	ENOG4105ES5	Histidine kinase
HWV54_RS06365	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWV54_RS06370	ENOG4105C1A	potassium transporter peripheral membrane
HWV54_RS06380	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HWV54_RS06385	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HWV54_RS06400	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
HWV54_RS06410	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HWV54_RS06415	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HWV54_RS06425	ENOG4106ECF	Uncharacterized protein conserved in bacteria (DUF2155)
HWV54_RS06435	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HWV54_RS06450	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HWV54_RS06460	ENOG410683Z	Preprotein translocase SecE subunit
HWV54_RS06470	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HWV54_RS06475	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HWV54_RS06480	ENOG4108VZM	50s ribosomal protein L10
HWV54_RS06485	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HWV54_RS06490	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HWV54_RS06495	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HWV54_RS06505	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HWV54_RS06510	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HWV54_RS06515	ENOG4105JUY	domain protein, FtsQ-type
HWV54_RS06520	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HWV54_RS06525	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HWV54_RS06530	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HWV54_RS06535	ENOG4108XM1	transcriptional regulator AsnC family
HWV54_RS06540	ENOG4108RG0	uracil-dna glycosylase
HWV54_RS06550	ENOG4105W0E	50S ribosomal protein L33
HWV54_RS06555	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HWV54_RS06565	ENOG4105C79	DNA protecting protein DprA
HWV54_RS06570	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HWV54_RS06575	ENOG4105CD3	dihydroorotase
HWV54_RS06580	ENOG4105CXT	aspartate transcarbamylase
HWV54_RS06590	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HWV54_RS06595	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HWV54_RS06600	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HWV54_RS06605	ENOG4108IV0	ABC, transporter
HWV54_RS06610	ENOG4105C0Z	ABC transporter
HWV54_RS06615	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HWV54_RS06620	ENOG4105C32	Amino acid ABC transporter (Permease)
HWV54_RS06630	ENOG4105VEQ	Cold shock protein
HWV54_RS06650	ENOG4105W5Q	DNA repair protein (RadC
HWV54_RS06655	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HWV54_RS06660	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HWV54_RS06670	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HWV54_RS06675	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HWV54_RS06680	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HWV54_RS06685	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HWV54_RS06690	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HWV54_RS06745	ENOG4108ZNX	Heat shock protein
HWV54_RS06755	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HWV54_RS06770	ENOG4105CPQ	Dehydrogenase
HWV54_RS06775	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HWV54_RS06780	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HWV54_RS06785	ENOG4105J3Q	acyl carrier protein
HWV54_RS06790	ENOG4105C6K	Malic enzyme
HWV54_RS06800	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HWV54_RS06805	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HWV54_RS06815	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)