locus-tag	class	description
HWV54_RS00005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HWV54_RS00010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HWV54_RS00015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWV54_RS00015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWV54_RS00025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HWV54_RS00030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWV54_RS00045	COG0416	fatty acid biosynthetic process
HWV54_RS00050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWV54_RS00055	COG0776	regulation of translation
HWV54_RS00065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HWV54_RS00070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HWV54_RS00080	COG0302	gtp cyclohydrolase
HWV54_RS00105	COG1760	l-serine dehydratase
HWV54_RS00115	COG1686	Belongs to the peptidase S11 family
HWV54_RS00130	COG0537	adenosine 5'-monophosphoramidase activity
HWV54_RS00145	COG0052	Belongs to the universal ribosomal protein uS2 family
HWV54_RS00150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HWV54_RS00155	COG0528	UMP kinase activity
HWV54_RS00160	COG0233	cytoplasmic translational termination
HWV54_RS00170	COG0750	zinc metalloprotease
HWV54_RS00175	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWV54_RS00180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWV54_RS00185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWV54_RS00190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWV54_RS00200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWV54_RS00205	COG1126	abc transporter atp-binding protein
HWV54_RS00215	COG4215	(ABC) transporter
HWV54_RS00220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV54_RS00225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV54_RS00230	COG0372	Belongs to the citrate synthase family
HWV54_RS00235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWV54_RS00245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HWV54_RS00260	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HWV54_RS00270	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HWV54_RS00270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWV54_RS00290	COG2986	histidine ammonia-lyase
HWV54_RS00325	COG2184	nucleotidyltransferase activity
HWV54_RS00345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWV54_RS00350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWV54_RS00355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWV54_RS00360	COG0649	NAD binding
HWV54_RS00365	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HWV54_RS00370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HWV54_RS00380	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HWV54_RS00385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWV54_RS00395	COG0713	ATP synthesis coupled electron transport
HWV54_RS00410	COG1007	ATP synthesis coupled electron transport
HWV54_RS00425	COG0442	prolyl-tRNA aminoacylation
HWV54_RS00435	COG1136	(ABC) transporter
HWV54_RS00440	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HWV54_RS00445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HWV54_RS00455	COG1530	ribonuclease E activity
HWV54_RS00460	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV54_RS00465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HWV54_RS00475	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWV54_RS00480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWV54_RS00485	COG2945	thiolester hydrolase activity
HWV54_RS00495	COG0719	Fe-S assembly protein
HWV54_RS00500	COG0396	ATPase activity
HWV54_RS00505	COG0719	Fe-S assembly protein
HWV54_RS00510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWV54_RS00520	COG2032	superoxide dismutase activity
HWV54_RS00535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWV54_RS00540	COG1183	phosphatidylcholine synthase activity
HWV54_RS00555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HWV54_RS00555	COG0321	lipoyl(octanoyl) transferase activity
HWV54_RS00560	COG0084	hydrolase, TatD family'
HWV54_RS00565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV54_RS00570	COG0470	DNA polymerase III
HWV54_RS00575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HWV54_RS00580	COG1686	Belongs to the peptidase S11 family
HWV54_RS00615	COG0628	permease
HWV54_RS00620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HWV54_RS00625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HWV54_RS00650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HWV54_RS00660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HWV54_RS00665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWV54_RS00670	COG0047	phosphoribosylformylglycinamidine synthase activity
HWV54_RS00675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWV54_RS00685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HWV54_RS00690	COG2814	Major facilitator Superfamily
HWV54_RS00695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWV54_RS00700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HWV54_RS00705	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HWV54_RS00715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HWV54_RS00725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWV54_RS00735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HWV54_RS00740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWV54_RS00745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HWV54_RS00750	COG0785	Cytochrome C biogenesis protein
HWV54_RS00760	COG0316	Belongs to the HesB IscA family
HWV54_RS00765	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HWV54_RS00770	COG0018	arginyl-trna synthetase
HWV54_RS00785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWV54_RS00805	COG0538	isocitrate dehydrogenase activity
HWV54_RS00815	COG2814	Major facilitator Superfamily
HWV54_RS00820	COG0343	queuine tRNA-ribosyltransferase activity
HWV54_RS00835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HWV54_RS00840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWV54_RS00855	COG0347	Belongs to the P(II) protein family
HWV54_RS00860	COG0174	glutamine synthetase
HWV54_RS00885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HWV54_RS00890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HWV54_RS00895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWV54_RS00900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV54_RS00905	COG0203	ribosomal protein L17
HWV54_RS00910	COG0202	RNA polymerase activity
HWV54_RS00915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HWV54_RS00920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HWV54_RS00925	COG0563	adenylate kinase activity
HWV54_RS00935	COG0200	Binds to the 23S rRNA
HWV54_RS00940	COG1841	ribosomal large subunit assembly
HWV54_RS00945	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HWV54_RS00950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HWV54_RS00955	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HWV54_RS00960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HWV54_RS00965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HWV54_RS00970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HWV54_RS00975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HWV54_RS00980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HWV54_RS00985	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HWV54_RS00990	COG0255	Belongs to the universal ribosomal protein uL29 family
HWV54_RS00995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HWV54_RS01000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HWV54_RS01005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HWV54_RS01010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HWV54_RS01015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HWV54_RS01020	COG0089	rRNA binding
HWV54_RS01025	COG0088	Forms part of the polypeptide exit tunnel
HWV54_RS01030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HWV54_RS01035	COG0051	transcription antitermination factor activity, RNA binding
HWV54_RS01040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HWV54_RS01045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HWV54_RS01050	COG0049	tRNA binding
HWV54_RS01055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HWV54_RS01060	COG0708	Exodeoxyribonuclease III
HWV54_RS01070	COG0765	amino acid transport
HWV54_RS01075	COG0765	amino acid transport
HWV54_RS01080	COG1126	abc transporter atp-binding protein
HWV54_RS01085	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HWV54_RS01090	COG0525	valine-tRNA ligase activity
HWV54_RS01105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HWV54_RS01120	COG0513	Belongs to the DEAD box helicase family
HWV54_RS01125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWV54_RS01135	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HWV54_RS01145	COG3264	Mechanosensitive ion channel
HWV54_RS01145	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HWV54_RS01160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWV54_RS01160	COG4651	solute:proton antiporter activity
HWV54_RS01170	COG1253	flavin adenine dinucleotide binding
HWV54_RS01220	COG0321	lipoyl(octanoyl) transferase activity
HWV54_RS01225	COG0187	DNA topoisomerase II activity
HWV54_RS01235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HWV54_RS01240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HWV54_RS01245	COG0784	Response regulator, receiver
HWV54_RS01255	COG1113	amino acid transport
HWV54_RS01260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HWV54_RS01270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWV54_RS01275	COG0028	Belongs to the TPP enzyme family
HWV54_RS01280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HWV54_RS01285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV54_RS01305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWV54_RS01310	COG0477	Major facilitator Superfamily
HWV54_RS01315	COG0477	Major facilitator Superfamily
HWV54_RS01320	COG0477	Major facilitator Superfamily
HWV54_RS01360	COG1999	signal sequence binding
HWV54_RS01370	COG0006	proline dipeptidase activity
HWV54_RS01375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWV54_RS01380	COG0497	DNA recombination
HWV54_RS01385	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWV54_RS01400	COG0849	cell division
HWV54_RS01410	COG1181	Belongs to the D-alanine--D-alanine ligase family
HWV54_RS01415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HWV54_RS01420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWV54_RS01425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWV54_RS01435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HWV54_RS01440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWV54_RS01465	COG0275	rRNA processing
HWV54_RS01475	COG0741	lytic transglycosylase activity
HWV54_RS01495	COG1335	isochorismatase
HWV54_RS01520	COG2968	Membrane
HWV54_RS01530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HWV54_RS01540	COG0668	transmembrane transport
HWV54_RS01555	COG3161	chorismate lyase activity
HWV54_RS01560	COG0505	Belongs to the CarA family
HWV54_RS01580	COG1278	Cold shock
HWV54_RS01585	COG0436	Aminotransferase
HWV54_RS01590	COG0583	DNA-binding transcription factor activity
HWV54_RS01595	COG0492	ferredoxin-NADP+ reductase activity
HWV54_RS01600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWV54_RS01610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWV54_RS01620	COG0556	nucleotide-excision repair
HWV54_RS01630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV54_RS01635	COG0745	RESPONSE REGULATOR receiver
HWV54_RS01655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HWV54_RS01680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HWV54_RS01685	COG0193	aminoacyl-tRNA hydrolase activity
HWV54_RS01690	COG1376	ErfK ybiS ycfS ynhG family protein
HWV54_RS01695	COG0012	GTP binding
HWV54_RS01720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HWV54_RS01725	COG0617	tRNA 3'-terminal CCA addition
HWV54_RS01730	COG0714	Associated with various cellular activities
HWV54_RS01755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWV54_RS01765	COG0482	sulfurtransferase activity
HWV54_RS01825	COG4608	Belongs to the ABC transporter superfamily
HWV54_RS01840	COG0601	transmembrane transport
HWV54_RS01845	COG0747	negative chemotaxis
HWV54_RS01855	COG0519	Catalyzes the synthesis of GMP from XMP
HWV54_RS01860	COG1570	exodeoxyribonuclease VII activity
HWV54_RS01865	COG0747	negative chemotaxis
HWV54_RS01885	COG0730	response to heat
HWV54_RS01895	COG2086	electron transfer activity
HWV54_RS01925	COG0792	nuclease activity
HWV54_RS01930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HWV54_RS01935	COG0489	protein tyrosine kinase activity
HWV54_RS01940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HWV54_RS01945	COG0594	ribonuclease P activity
HWV54_RS01955	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HWV54_RS01965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HWV54_RS01970	COG0588	phosphoglycerate mutase activity
HWV54_RS01995	COG3023	N-Acetylmuramoyl-L-alanine amidase
HWV54_RS02005	COG2814	Major facilitator Superfamily
HWV54_RS02090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWV54_RS02090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWV54_RS02095	COG0509	glycine decarboxylation via glycine cleavage system
HWV54_RS02100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWV54_RS02105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HWV54_RS02110	COG2835	tetraacyldisaccharide 4'-kinase activity
HWV54_RS02115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HWV54_RS02130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWV54_RS02135	COG2011	ABC-type metal ion transport system permease component
HWV54_RS02160	COG0523	cobalamin synthesis protein
HWV54_RS02190	COG4607	ABC-type enterochelin transport system periplasmic component
HWV54_RS02195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV54_RS02200	COG4605	iron ion homeostasis
HWV54_RS02205	COG4604	ABC transporter, ATP-binding protein
HWV54_RS02270	COG1192	Involved in chromosome partitioning
HWV54_RS02280	COG0196	riboflavin kinase activity
HWV54_RS02305	COG3838	Conjugal transfer protein Trbc
HWV54_RS02310	COG3702	type iv secretory pathway
HWV54_RS02315	COG3451	type IV secretory pathway VirB4
HWV54_RS02330	COG3704	protein secretion by the type IV secretion system
HWV54_RS02340	COG3736	Type IV secretory pathway, component VirB8
HWV54_RS02345	COG3504	Conjugal transfer protein
HWV54_RS02350	COG2948	multi-organism process
HWV54_RS02355	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HWV54_RS02360	COG3077	Addiction module antitoxin, RelB DinJ family
HWV54_RS02440	COG5314	conjugation
HWV54_RS02445	COG3451	type IV secretory pathway VirB4
HWV54_RS02455	COG3838	Conjugal transfer protein Trbc
HWV54_RS02460	COG4962	Type ii secretion system protein e
HWV54_RS02505	COG2948	multi-organism process
HWV54_RS02520	COG3701	Conjugal transfer protein
HWV54_RS02535	COG3838	Conjugal transfer protein Trbc
HWV54_RS02540	COG3702	type iv secretory pathway
HWV54_RS02545	COG3451	type IV secretory pathway VirB4
HWV54_RS02555	COG3704	protein secretion by the type IV secretion system
HWV54_RS02565	COG3736	Type IV secretory pathway, component VirB8
HWV54_RS02570	COG3504	Conjugal transfer protein
HWV54_RS02575	COG2948	multi-organism process
HWV54_RS02580	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HWV54_RS02590	COG2184	nucleotidyltransferase activity
HWV54_RS02595	COG3505	Type IV secretory pathway VirD4
HWV54_RS02600	COG2184	nucleotidyltransferase activity
HWV54_RS02620	COG2184	nucleotidyltransferase activity
HWV54_RS02625	COG0728	peptidoglycan biosynthetic process
HWV54_RS02630	COG0180	Tryptophanyl-tRNA synthetase
HWV54_RS02640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HWV54_RS02645	COG2824	Alkylphosphonate utilization operon protein PhnA
HWV54_RS02650	COG0459	protein refolding
HWV54_RS02655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HWV54_RS02665	COG0033	Phosphoglucomutase
HWV54_RS02680	COG0124	histidyl-tRNA synthetase
HWV54_RS02695	COG0284	orotidine-5'-phosphate decarboxylase activity
HWV54_RS02745	COG3920	Histidine kinase
HWV54_RS02760	COG0784	Response regulator, receiver
HWV54_RS02855	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HWV54_RS02860	COG0424	maF-like protein
HWV54_RS02865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HWV54_RS02875	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HWV54_RS02880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HWV54_RS02890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HWV54_RS02900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HWV54_RS02905	COG0457	Tetratricopeptide repeat
HWV54_RS02930	COG1692	metallophosphoesterase
HWV54_RS02935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWV54_RS03025	COG1238	metal cluster binding
HWV54_RS03040	COG0756	dUTP diphosphatase activity
HWV54_RS03060	COG0848	biopolymer transport protein
HWV54_RS03065	COG0811	peptide transport
HWV54_RS03080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWV54_RS03085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWV54_RS03090	COG0037	tRNA processing
HWV54_RS03100	COG2885	chlorophyll binding
HWV54_RS03110	COG0217	transcriptional regulatory protein
HWV54_RS03115	COG0823	Involved in the tonB-independent uptake of proteins
HWV54_RS03135	COG0824	Thioesterase
HWV54_RS03140	COG2255	four-way junction helicase activity
HWV54_RS03145	COG0632	four-way junction helicase activity
HWV54_RS03150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HWV54_RS03175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HWV54_RS03180	COG0483	inositol monophosphate 1-phosphatase activity
HWV54_RS03185	COG1132	(ABC) transporter
HWV54_RS03190	COG0254	rRNA binding
HWV54_RS03195	COG3588	fructose-bisphosphate aldolase
HWV54_RS03200	COG0126	phosphoglycerate kinase activity
HWV54_RS03225	COG0469	pyruvate kinase activity
HWV54_RS03235	COG3750	Belongs to the UPF0335 family
HWV54_RS03260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HWV54_RS03270	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HWV54_RS03280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HWV54_RS03285	COG0142	geranyltranstransferase activity
HWV54_RS03310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HWV54_RS03320	COG1566	PFAM secretion protein HlyD family protein
HWV54_RS03330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HWV54_RS03335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HWV54_RS03340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HWV54_RS03345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HWV54_RS03350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HWV54_RS03360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HWV54_RS03370	COG0495	leucyl-tRNA aminoacylation
HWV54_RS03380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWV54_RS03385	COG2884	Cell division ATP-binding protein ftsE
HWV54_RS03400	COG1136	(ABC) transporter
HWV54_RS03400	COG0577	efflux transmembrane transporter activity
HWV54_RS03405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWV54_RS03425	COG1674	ftsk spoiiie
HWV54_RS03430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWV54_RS03510	COG2948	multi-organism process
HWV54_RS03540	COG0335	large ribosomal subunit rRNA binding
HWV54_RS03545	COG0336	Belongs to the RNA methyltransferase TrmD family
HWV54_RS03550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HWV54_RS03590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HWV54_RS03600	COG0138	bifunctional purine biosynthesis protein purh
HWV54_RS03610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWV54_RS03610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HWV54_RS03615	COG0501	Belongs to the peptidase M48B family
HWV54_RS03625	COG0228	four-way junction DNA binding
HWV54_RS03635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWV54_RS03640	COG0288	reversible hydration of carbon dioxide
HWV54_RS03645	COG2902	Dehydrogenase
HWV54_RS03655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWV54_RS03655	COG0519	Catalyzes the synthesis of GMP from XMP
HWV54_RS03670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HWV54_RS03685	COG0745	RESPONSE REGULATOR receiver
HWV54_RS03690	COG2226	methyltransferase
HWV54_RS03700	COG0019	diaminopimelate decarboxylase activity
HWV54_RS03730	COG0287	Prephenate dehydrogenase
HWV54_RS03740	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HWV54_RS03770	COG1686	Belongs to the peptidase S11 family
HWV54_RS03775	COG0523	cobalamin synthesis protein
HWV54_RS03780	COG3034	peptidoglycan biosynthetic process
HWV54_RS03785	COG0825	malonyl-CoA metabolic process
HWV54_RS03800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HWV54_RS03805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HWV54_RS03815	COG3895	Periplasmic Protein
HWV54_RS03825	COG2212	antiporter activity
HWV54_RS03830	COG1863	multisubunit Na H antiporter MnhE subunit
HWV54_RS03835	COG0651	ATP synthesis coupled electron transport
HWV54_RS03840	COG1006	Multisubunit Na H antiporter MnhC subunit
HWV54_RS03845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWV54_RS03845	COG2111	Na H antiporter
HWV54_RS03855	COG0019	diaminopimelate decarboxylase activity
HWV54_RS03870	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV54_RS03875	COG0567	Dehydrogenase, E1 component
HWV54_RS03880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HWV54_RS03885	COG0045	succinate-CoA ligase (ADP-forming) activity
HWV54_RS03890	COG0039	L-malate dehydrogenase activity
HWV54_RS03895	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HWV54_RS03905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HWV54_RS03910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWV54_RS03915	COG0552	protein localization to endoplasmic reticulum
HWV54_RS03925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV54_RS03940	COG0357	Ribosomal RNA small subunit methyltransferase G
HWV54_RS03945	COG0445	tRNA wobble uridine modification
HWV54_RS03950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HWV54_RS03955	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HWV54_RS03960	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HWV54_RS03965	COG0424	maF-like protein
HWV54_RS03970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HWV54_RS03975	COG0237	dephospho-CoA kinase activity
HWV54_RS03985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWV54_RS03985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWV54_RS03995	COG0670	Belongs to the BI1 family
HWV54_RS04000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HWV54_RS04010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HWV54_RS04010	COG0116	Belongs to the methyltransferase superfamily
HWV54_RS04020	COG0776	regulation of translation
HWV54_RS04035	COG1137	ATPase activity
HWV54_RS04040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV54_RS04050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HWV54_RS04070	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HWV54_RS04080	COG1074	ATP-dependent DNA helicase activity
HWV54_RS04085	COG2887	Belongs to the helicase family. UvrD subfamily
HWV54_RS04095	COG2205	protein histidine kinase activity
HWV54_RS04100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HWV54_RS04105	COG0702	epimerase
HWV54_RS04110	COG0285	dihydrofolate synthase activity
HWV54_RS04115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HWV54_RS04125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWV54_RS04130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HWV54_RS04135	COG2226	methyltransferase
HWV54_RS04150	COG0606	chelatase, subunit chli
HWV54_RS04165	COG1132	(ABC) transporter
HWV54_RS04170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HWV54_RS04185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWV54_RS04190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWV54_RS04195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HWV54_RS04200	COG1420	regulation of RNA biosynthetic process
HWV54_RS04205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HWV54_RS04220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV54_RS04220	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV54_RS04225	COG0396	ATPase activity
HWV54_RS04230	COG2205	protein histidine kinase activity
HWV54_RS04235	COG0745	RESPONSE REGULATOR receiver
HWV54_RS04240	COG1652	LysM domain
HWV54_RS04250	COG0443	Heat shock 70 kDa protein
HWV54_RS04255	COG0484	heat shock protein binding
HWV54_RS04260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HWV54_RS04270	COG0481	GTPase activity
HWV54_RS04275	COG2171	N-acyltransferase activity
HWV54_RS04285	COG0101	tRNA pseudouridine synthase activity
HWV54_RS04290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HWV54_RS04295	COG0242	peptide deformylase activity
HWV54_RS04325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HWV54_RS04330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HWV54_RS04335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HWV54_RS04340	COG0072	phenylalanine-tRNA ligase activity
HWV54_RS04340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV54_RS04350	COG1121	(ABC) transporter
HWV54_RS04355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWV54_RS04360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWV54_RS04365	COG2832	Protein of unknown function (DUF454)
HWV54_RS04370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HWV54_RS04380	COG0539	negative regulation of cytoplasmic translation
HWV54_RS04385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HWV54_RS04390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HWV54_RS04405	COG0129	dihydroxy-acid dehydratase activity
HWV54_RS04410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HWV54_RS04415	COG0281	malic enzyme
HWV54_RS04415	COG0280	phosphate acetyltransferase
HWV54_RS04420	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HWV54_RS04425	COG3030	protein affecting phage T7 exclusion by the F plasmid
HWV54_RS04445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWV54_RS04455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV54_RS04460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWV54_RS04465	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWV54_RS04470	COG4133	protoheme IX ABC transporter activity
HWV54_RS04475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HWV54_RS04480	COG0268	Binds directly to 16S ribosomal RNA
HWV54_RS04485	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HWV54_RS04500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HWV54_RS04505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWV54_RS04510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWV54_RS04515	COG1845	cytochrome c oxidase, subunit III
HWV54_RS04525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HWV54_RS04530	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HWV54_RS04540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWV54_RS04555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HWV54_RS04560	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HWV54_RS04575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWV54_RS04580	COG0166	Belongs to the GPI family
HWV54_RS04590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV54_RS04590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWV54_RS04600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HWV54_RS04605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HWV54_RS04655	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HWV54_RS04660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HWV54_RS04665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HWV54_RS04670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HWV54_RS04675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HWV54_RS04680	COG0799	negative regulation of ribosome biogenesis
HWV54_RS04685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HWV54_RS04695	COG0793	Belongs to the peptidase S41A family
HWV54_RS04700	COG0494	nUDIX hydrolase
HWV54_RS04705	COG5342	invasion associated locus B
HWV54_RS04715	COG1872	DUF167
HWV54_RS04720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HWV54_RS04730	COG2239	Acts as a magnesium transporter
HWV54_RS04735	COG0339	signal peptide processing
HWV54_RS04745	COG2951	lytic endotransglycosylase activity
HWV54_RS04750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWV54_RS04755	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HWV54_RS04755	COG0517	IMP dehydrogenase activity
HWV54_RS04765	COG2204	response regulator
HWV54_RS04770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWV54_RS04785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HWV54_RS04785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWV54_RS04790	COG0519	Catalyzes the synthesis of GMP from XMP
HWV54_RS04790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWV54_RS04800	COG3842	ATPase activity
HWV54_RS04805	COG0395	ABC-type sugar transport system, permease component
HWV54_RS04810	COG1175	transmembrane transport
HWV54_RS04820	COG0803	Belongs to the bacterial solute-binding protein 9 family
HWV54_RS04825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWV54_RS04840	COG1780	Probably involved in ribonucleotide reductase function
HWV54_RS04845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWV54_RS04855	COG2890	protein-(glutamine-N5) methyltransferase activity
HWV54_RS04860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HWV54_RS04870	COG0653	protein targeting
HWV54_RS04880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HWV54_RS04895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HWV54_RS04900	COG1072	(Pantothenic acid kinase))
HWV54_RS04905	COG0252	asparaginase activity
HWV54_RS04910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HWV54_RS04915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HWV54_RS04920	COG2813	Specifically methylates the guanine in position
HWV54_RS04925	COG1185	polyribonucleotide nucleotidyltransferase activity
HWV54_RS04930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HWV54_RS04940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HWV54_RS04945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HWV54_RS04950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HWV54_RS04960	COG0195	Participates in both transcription termination and antitermination
HWV54_RS04960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWV54_RS04965	COG0779	Required for maturation of 30S ribosomal subunits
HWV54_RS04970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HWV54_RS04975	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HWV54_RS04980	COG1396	sequence-specific DNA binding
HWV54_RS04990	COG4535	Mg2 and Co2 transporter CorC
HWV54_RS04995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HWV54_RS05000	COG1702	phosphate starvation-inducible protein PhoH
HWV54_RS05005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWV54_RS05015	COG1214	PFAM Peptidase M22, glycoprotease
HWV54_RS05020	COG2855	membrane
HWV54_RS05025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HWV54_RS05030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HWV54_RS05045	COG1605	Chorismate mutase
HWV54_RS05045	COG0077	Prephenate dehydratase
HWV54_RS05050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HWV54_RS05055	COG3474	cytochrome
HWV54_RS05060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWV54_RS05075	COG0189	ligase activity
HWV54_RS05085	COG0573	inorganic phosphate transmembrane transporter activity
HWV54_RS05095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWV54_RS05100	COG0704	Plays a role in the regulation of phosphate uptake
HWV54_RS05115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HWV54_RS05135	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HWV54_RS05140	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HWV54_RS05145	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HWV54_RS05150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HWV54_RS05160	COG0590	tRNA wobble adenosine to inosine editing
HWV54_RS05170	COG0742	ribosomal rna small subunit methyltransferase
HWV54_RS05180	COG1304	FMN binding
HWV54_RS05185	COG0717	Belongs to the dCTP deaminase family
HWV54_RS05190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HWV54_RS05200	COG1663	tetraacyldisaccharide 4'-kinase activity
HWV54_RS05205	COG1519	Transferase
HWV54_RS05215	COG0483	inositol monophosphate 1-phosphatase activity
HWV54_RS05220	COG0312	modulator of DNA gyrase
HWV54_RS05245	COG1113	amino acid transport
HWV54_RS05250	COG1122	ATPase activity
HWV54_RS05260	COG1268	BioY protein
HWV54_RS05275	COG0436	Aminotransferase
HWV54_RS05290	COG0189	ligase activity
HWV54_RS05295	COG4555	ABC transporter
HWV54_RS05350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HWV54_RS05360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HWV54_RS05365	COG0564	pseudouridine synthase activity
HWV54_RS05385	COG1970	mechanosensitive ion channel activity
HWV54_RS05390	COG0167	dihydroorotate dehydrogenase activity
HWV54_RS05405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWV54_RS05410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HWV54_RS05415	COG0363	glucosamine-6-phosphate deaminase activity
HWV54_RS05425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HWV54_RS05445	COG3572	ergothioneine biosynthetic process
HWV54_RS05465	COG1040	competence protein
HWV54_RS05470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HWV54_RS05475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWV54_RS05480	COG0527	aspartate kinase activity
HWV54_RS05485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HWV54_RS05495	COG3273	potassium ion transport
HWV54_RS05495	COG0471	metal ion transport
HWV54_RS05505	COG1160	GTP binding
HWV54_RS05515	COG0356	it plays a direct role in the translocation of protons across the membrane
HWV54_RS05525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HWV54_RS05530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HWV54_RS05535	COG0751	glycine-tRNA ligase activity
HWV54_RS05550	COG0142	geranyltranstransferase activity
HWV54_RS05565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HWV54_RS05570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWV54_RS05575	COG0009	L-threonylcarbamoyladenylate synthase
HWV54_RS05580	COG0277	FAD linked oxidase domain protein
HWV54_RS05595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HWV54_RS05600	COG0259	pyridoxamine-phosphate oxidase activity
HWV54_RS05605	COG0484	heat shock protein binding
HWV54_RS05610	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HWV54_RS05615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HWV54_RS05620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWV54_RS05620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWV54_RS05625	COG1722	exodeoxyribonuclease VII activity
HWV54_RS05630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HWV54_RS05645	COG0312	modulator of DNA gyrase
HWV54_RS05655	COG0109	protoheme IX farnesyltransferase activity
HWV54_RS05660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HWV54_RS05665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV54_RS05670	COG0328	RNA-DNA hybrid ribonuclease activity
HWV54_RS05680	COG1678	Uncharacterized ACR, COG1678
HWV54_RS05690	COG0612	Peptidase, M16
HWV54_RS05725	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HWV54_RS05730	COG1194	a g-specific adenine glycosylase
HWV54_RS05740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HWV54_RS05740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWV54_RS05745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWV54_RS05745	COG0574	Belongs to the PEP-utilizing enzyme family
HWV54_RS05760	COG2166	iron-sulfur cluster assembly
HWV54_RS05775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWV54_RS05805	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HWV54_RS05815	COG0745	RESPONSE REGULATOR receiver
HWV54_RS05820	COG5002	protein histidine kinase activity
HWV54_RS05830	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HWV54_RS05835	COG1138	Cytochrome C-type biogenesis protein
HWV54_RS05840	COG3088	subunit of a heme lyase
HWV54_RS05845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV54_RS05850	COG0745	RESPONSE REGULATOR receiver
HWV54_RS05855	COG0642	Histidine kinase
HWV54_RS05865	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HWV54_RS05875	COG2202	Pas domain
HWV54_RS05875	COG2205	protein histidine kinase activity
HWV54_RS05880	COG0308	aminopeptidase N
HWV54_RS05890	COG0351	phosphomethylpyrimidine kinase
HWV54_RS05900	COG2022	thiamine diphosphate biosynthetic process
HWV54_RS05915	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HWV54_RS05925	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HWV54_RS05930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV54_RS05935	COG4558	Periplasmic binding protein
HWV54_RS05940	COG3720	iron ion transport
HWV54_RS05960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWV54_RS05965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HWV54_RS05970	COG1573	uracil-dna glycosylase
HWV54_RS05975	COG1758	RNA polymerase activity
HWV54_RS05980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWV54_RS05985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HWV54_RS05995	COG0736	holo-[acyl-carrier-protein] synthase activity
HWV54_RS06000	COG0681	Belongs to the peptidase S26 family
HWV54_RS06005	COG0571	ribonuclease III activity
HWV54_RS06015	COG1381	Involved in DNA repair and RecF pathway recombination
HWV54_RS06020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HWV54_RS06025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HWV54_RS06030	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HWV54_RS06035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWV54_RS06040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWV54_RS06050	COG0215	cysteine-tRNA ligase activity
HWV54_RS06060	COG5265	(ABC) transporter
HWV54_RS06065	COG0688	phosphatidylethanolamine metabolic process
HWV54_RS06070	COG1183	phosphatidylcholine synthase activity
HWV54_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
HWV54_RS06080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HWV54_RS06095	COG0305	Participates in initiation and elongation during chromosome replication
HWV54_RS06100	COG0359	binds to the 23S rRNA
HWV54_RS06110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HWV54_RS06115	COG0360	Binds together with S18 to 16S ribosomal RNA
HWV54_RS06120	COG0671	phosphoesterase, PA-phosphatase related
HWV54_RS06125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWV54_RS06135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV54_RS06140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWV54_RS06145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWV54_RS06150	COG0194	GDP metabolic process
HWV54_RS06155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HWV54_RS06160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HWV54_RS06170	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HWV54_RS06195	COG0477	Major facilitator Superfamily
HWV54_RS06210	COG0105	UTP biosynthetic process
HWV54_RS06215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HWV54_RS06220	COG0322	excinuclease ABC activity
HWV54_RS06225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HWV54_RS06230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWV54_RS06235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWV54_RS06240	COG0805	protein transport
HWV54_RS06245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HWV54_RS06250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HWV54_RS06255	COG4942	peptidase
HWV54_RS06255	COG1388	LysM domain
HWV54_RS06260	COG1862	Preprotein translocase
HWV54_RS06280	COG0149	triose-phosphate isomerase activity
HWV54_RS06285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWV54_RS06290	COG0504	CTP synthase activity
HWV54_RS06295	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HWV54_RS06300	COG0148	phosphopyruvate hydratase activity
HWV54_RS06315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWV54_RS06320	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV54_RS06320	COG0022	dehydrogenase e1 component
HWV54_RS06325	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV54_RS06330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWV54_RS06335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWV54_RS06340	COG2867	negative regulation of translational initiation
HWV54_RS06345	COG1546	Belongs to the CinA family
HWV54_RS06345	COG1058	Belongs to the CinA family
HWV54_RS06350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HWV54_RS06350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HWV54_RS06355	COG1959	2 iron, 2 sulfur cluster binding
HWV54_RS06360	COG5000	phosphorelay sensor kinase activity
HWV54_RS06365	COG2204	response regulator
HWV54_RS06370	COG0569	domain protein
HWV54_RS06380	COG0740	serine-type endopeptidase activity
HWV54_RS06385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HWV54_RS06400	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HWV54_RS06410	COG0544	peptidyl-prolyl cis-trans isomerase activity
HWV54_RS06415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWV54_RS06425	COG4765	Protein conserved in bacteria
HWV54_RS06435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWV54_RS06450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HWV54_RS06460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWV54_RS06470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HWV54_RS06475	COG0081	regulation of translation
HWV54_RS06480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HWV54_RS06485	COG0222	ribosome binding
HWV54_RS06490	COG0085	RNA polymerase activity
HWV54_RS06495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HWV54_RS06510	COG0511	ligase activity, forming carbon-carbon bonds
HWV54_RS06525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWV54_RS06530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HWV54_RS06535	COG1522	sequence-specific DNA binding
HWV54_RS06540	COG1573	uracil-dna glycosylase
HWV54_RS06550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HWV54_RS06555	COG0557	exoribonuclease II activity
HWV54_RS06560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HWV54_RS06565	COG0758	DNA mediated transformation
HWV54_RS06570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HWV54_RS06575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWV54_RS06580	COG0540	Belongs to the ATCase OTCase family
HWV54_RS06590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HWV54_RS06595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWV54_RS06600	COG0154	amidase activity
HWV54_RS06630	COG1278	Cold shock
HWV54_RS06640	COG0596	Alpha beta hydrolase
HWV54_RS06650	COG2003	Belongs to the UPF0758 family
HWV54_RS06655	COG0024	Methionine aminopeptidase
HWV54_RS06660	COG1489	DNA binding
HWV54_RS06670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWV54_RS06675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HWV54_RS06680	COG0037	tRNA processing
HWV54_RS06685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWV54_RS06690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWV54_RS06745	COG0071	Belongs to the small heat shock protein (HSP20) family
HWV54_RS06755	COG0316	Belongs to the HesB IscA family
HWV54_RS06770	COG1063	alcohol dehydrogenase
HWV54_RS06775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWV54_RS06780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWV54_RS06785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV54_RS06790	COG0280	phosphate acetyltransferase
HWV54_RS06790	COG0281	malic enzyme
HWV54_RS06800	COG1923	regulation of RNA biosynthetic process
HWV54_RS06805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWV54_RS06815	COG1612	heme a metabolic process