locus-tag	class	description
PU02_RS00015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PU02_RS00015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PU02_RS00020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PU02_RS00025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PU02_RS00035	COG0166	Belongs to the GPI family
PU02_RS00040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PU02_RS00055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PU02_RS00075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PU02_RS00080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PU02_RS00095	COG0167	dihydroorotate dehydrogenase activity
PU02_RS00100	COG1970	mechanosensitive ion channel activity
PU02_RS00115	COG0564	pseudouridine synthase activity
PU02_RS00120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PU02_RS00130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PU02_RS00135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PU02_RS00180	COG3561	AntA/AntB antirepressor
PU02_RS00325	COG3077	Addiction module antitoxin, RelB DinJ family
PU02_RS00335	COG3561	AntA/AntB antirepressor
PU02_RS00345	COG4680	protein conserved in bacteria
PU02_RS00385	COG3561	AntA/AntB antirepressor
PU02_RS00480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PU02_RS00515	COG0735	belongs to the Fur family
PU02_RS00540	COG1054	Belongs to the UPF0176 family
PU02_RS00555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PU02_RS00555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PU02_RS00560	COG0509	glycine decarboxylation via glycine cleavage system
PU02_RS00565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PU02_RS00570	COG2835	tetraacyldisaccharide 4'-kinase activity
PU02_RS00575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PU02_RS00585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PU02_RS00590	COG2011	ABC-type metal ion transport system permease component
PU02_RS00645	COG4605	iron ion homeostasis
PU02_RS00650	COG4604	ABC transporter, ATP-binding protein
PU02_RS00665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PU02_RS00745	COG1338	Plays a role in the flagellum-specific transport system
PU02_RS00755	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PU02_RS00765	COG1706	bacterial-type flagellum-dependent cell motility
PU02_RS00770	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
PU02_RS00775	COG4786	Flagellar basal body rod
PU02_RS00780	COG1677	Flagellar hook-basal body complex protein FliE
PU02_RS00785	COG1558	bacterial-type flagellum-dependent cell motility
PU02_RS00790	COG1815	bacterial-type flagellum-dependent cell motility
PU02_RS00795	COG1157	protein secretion by the type III secretion system
PU02_RS00800	COG4786	Flagellar basal body rod
PU02_RS00810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PU02_RS00825	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PU02_RS00830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PU02_RS00835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PU02_RS00865	COG1684	flagellar biosynthetic protein fliR
PU02_RS00870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PU02_RS00880	COG0196	riboflavin kinase activity
PU02_RS00890	COG0728	peptidoglycan biosynthetic process
PU02_RS00895	COG0180	Tryptophanyl-tRNA synthetase
PU02_RS00900	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PU02_RS00905	COG0459	protein refolding
PU02_RS00910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PU02_RS00920	COG0033	Phosphoglucomutase
PU02_RS00930	COG0124	histidyl-tRNA synthetase
PU02_RS00935	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PU02_RS00975	COG3838	Conjugal transfer protein Trbc
PU02_RS00980	COG3702	type iv secretory pathway
PU02_RS00985	COG3451	type IV secretory pathway VirB4
PU02_RS00995	COG3704	protein secretion by the type IV secretion system
PU02_RS01005	COG3736	Type IV secretory pathway, component VirB8
PU02_RS01010	COG3504	Conjugal transfer protein
PU02_RS01015	COG2948	multi-organism process
PU02_RS01020	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
PU02_RS01025	COG2184	nucleotidyltransferase activity
PU02_RS01030	COG3505	Type IV secretory pathway VirD4
PU02_RS01040	COG2184	nucleotidyltransferase activity
PU02_RS01050	COG2184	nucleotidyltransferase activity
PU02_RS01055	COG2184	nucleotidyltransferase activity
PU02_RS01065	COG2184	nucleotidyltransferase activity
PU02_RS01075	COG2184	nucleotidyltransferase activity
PU02_RS01115	COG2184	nucleotidyltransferase activity
PU02_RS01135	COG2184	nucleotidyltransferase activity
PU02_RS01140	COG2184	nucleotidyltransferase activity
PU02_RS01145	COG2184	nucleotidyltransferase activity
PU02_RS01155	COG2184	nucleotidyltransferase activity
PU02_RS01160	COG2184	nucleotidyltransferase activity
PU02_RS01165	COG2184	nucleotidyltransferase activity
PU02_RS01175	COG2184	nucleotidyltransferase activity
PU02_RS01285	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PU02_RS01290	COG0424	maF-like protein
PU02_RS01295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PU02_RS01300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PU02_RS01305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PU02_RS01310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PU02_RS01315	COG0457	Tetratricopeptide repeat
PU02_RS01330	COG1692	metallophosphoesterase
PU02_RS01335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PU02_RS01390	COG1238	metal cluster binding
PU02_RS01405	COG0756	dUTP diphosphatase activity
PU02_RS01410	COG0848	biopolymer transport protein
PU02_RS01425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PU02_RS01430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PU02_RS01435	COG0037	tRNA processing
PU02_RS01440	COG2885	chlorophyll binding
PU02_RS01450	COG0217	transcriptional regulatory protein
PU02_RS01455	COG0254	rRNA binding
PU02_RS01460	COG1132	(ABC) transporter
PU02_RS01465	COG0483	inositol monophosphate 1-phosphatase activity
PU02_RS01470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PU02_RS01495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PU02_RS01500	COG0632	four-way junction helicase activity
PU02_RS01505	COG2255	four-way junction helicase activity
PU02_RS01510	COG0824	Thioesterase
PU02_RS01530	COG0823	Involved in the tonB-independent uptake of proteins
PU02_RS01535	COG3588	fructose-bisphosphate aldolase
PU02_RS01540	COG0126	phosphoglycerate kinase activity
PU02_RS01575	COG3750	Belongs to the UPF0335 family
PU02_RS01580	COG0488	(ABC) transporter
PU02_RS01595	COG4783	chaperone-mediated protein folding
PU02_RS01600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PU02_RS01610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PU02_RS01620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PU02_RS01630	COG0142	geranyltranstransferase activity
PU02_RS01635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PU02_RS01640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PU02_RS01645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PU02_RS01650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PU02_RS01655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PU02_RS01660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PU02_RS01675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PU02_RS01685	COG0495	leucyl-tRNA aminoacylation
PU02_RS01690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PU02_RS01695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PU02_RS01700	COG2884	Cell division ATP-binding protein ftsE
PU02_RS01715	COG1136	(ABC) transporter
PU02_RS01715	COG0577	efflux transmembrane transporter activity
PU02_RS01720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PU02_RS01735	COG1674	ftsk spoiiie
PU02_RS01740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PU02_RS01760	COG2009	succinate dehydrogenase
PU02_RS01765	COG0335	large ribosomal subunit rRNA binding
PU02_RS01770	COG0336	Belongs to the RNA methyltransferase TrmD family
PU02_RS01775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PU02_RS01815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PU02_RS01825	COG0138	bifunctional purine biosynthesis protein purh
PU02_RS01840	COG0501	Belongs to the peptidase M48B family
PU02_RS01850	COG0228	four-way junction DNA binding
PU02_RS01860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PU02_RS01870	COG0288	reversible hydration of carbon dioxide
PU02_RS01875	COG2902	Dehydrogenase
PU02_RS01890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PU02_RS01905	COG0745	RESPONSE REGULATOR receiver
PU02_RS01920	COG0019	diaminopimelate decarboxylase activity
PU02_RS01930	COG0165	Argininosuccinate lyase
PU02_RS01935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PU02_RS01940	COG1671	Belongs to the UPF0178 family
PU02_RS01950	COG1122	ATPase activity
PU02_RS01975	COG1686	Belongs to the peptidase S11 family
PU02_RS01980	COG3034	peptidoglycan biosynthetic process
PU02_RS01985	COG0825	malonyl-CoA metabolic process
PU02_RS02000	COG1320	monovalent cation:proton antiporter activity
PU02_RS02005	COG2212	antiporter activity
PU02_RS02010	COG1863	multisubunit Na H antiporter MnhE subunit
PU02_RS02015	COG0651	ATP synthesis coupled electron transport
PU02_RS02020	COG1006	Multisubunit Na H antiporter MnhC subunit
PU02_RS02025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PU02_RS02025	COG2111	Na H antiporter
PU02_RS02030	COG0019	diaminopimelate decarboxylase activity
PU02_RS02040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PU02_RS02045	COG0508	dehydrogenase complex catalyzes the overall conversion of
PU02_RS02050	COG0567	Dehydrogenase, E1 component
PU02_RS02055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PU02_RS02060	COG0045	succinate-CoA ligase (ADP-forming) activity
PU02_RS02065	COG0039	L-malate dehydrogenase activity
PU02_RS02070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PU02_RS02080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PU02_RS02085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PU02_RS02090	COG0552	protein localization to endoplasmic reticulum
PU02_RS02095	COG2917	probably involved in intracellular septation
PU02_RS02115	COG0357	Ribosomal RNA small subunit methyltransferase G
PU02_RS02120	COG0445	tRNA wobble uridine modification
PU02_RS02125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PU02_RS02130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PU02_RS02135	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PU02_RS02140	COG0424	maF-like protein
PU02_RS02145	COG0237	dephospho-CoA kinase activity
PU02_RS02150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PU02_RS02155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PU02_RS02155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PU02_RS02160	COG0670	Belongs to the BI1 family
PU02_RS02165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PU02_RS02170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PU02_RS02175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PU02_RS02175	COG0116	Belongs to the methyltransferase superfamily
PU02_RS02185	COG0776	regulation of translation
PU02_RS02200	COG1137	ATPase activity
PU02_RS02205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PU02_RS02215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PU02_RS02220	COG1280	lysine exporter protein (LysE YggA)
PU02_RS02225	COG0137	argininosuccinate synthase activity
PU02_RS02235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PU02_RS02245	COG1074	ATP-dependent DNA helicase activity
PU02_RS02250	COG2887	Belongs to the helicase family. UvrD subfamily
PU02_RS02260	COG2205	protein histidine kinase activity
PU02_RS02265	COG0702	epimerase
PU02_RS02270	COG0285	dihydrofolate synthase activity
PU02_RS02275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PU02_RS02285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PU02_RS02290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PU02_RS02295	COG2226	methyltransferase
PU02_RS02320	COG1132	(ABC) transporter
PU02_RS02325	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PU02_RS02340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PU02_RS02345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PU02_RS02350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PU02_RS02355	COG1420	regulation of RNA biosynthetic process
PU02_RS02360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PU02_RS02365	COG2205	protein histidine kinase activity
PU02_RS02370	COG0745	RESPONSE REGULATOR receiver
PU02_RS02385	COG0443	Heat shock 70 kDa protein
PU02_RS02390	COG0484	heat shock protein binding
PU02_RS02395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PU02_RS02405	COG0481	GTPase activity
PU02_RS02410	COG2171	N-acyltransferase activity
PU02_RS02420	COG0101	tRNA pseudouridine synthase activity
PU02_RS02425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PU02_RS02430	COG0242	peptide deformylase activity
PU02_RS02455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PU02_RS02460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PU02_RS02465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PU02_RS02470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PU02_RS02470	COG0072	phenylalanine-tRNA ligase activity
PU02_RS02480	COG1121	(ABC) transporter
PU02_RS02485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PU02_RS02490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PU02_RS02495	COG2832	Protein of unknown function (DUF454)
PU02_RS02500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PU02_RS02510	COG0539	negative regulation of cytoplasmic translation
PU02_RS02515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PU02_RS02535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PU02_RS02540	COG0280	phosphate acetyltransferase
PU02_RS02540	COG0281	malic enzyme
PU02_RS02545	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PU02_RS02550	COG3030	protein affecting phage T7 exclusion by the F plasmid
PU02_RS02575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PU02_RS02585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PU02_RS02590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PU02_RS02595	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PU02_RS02600	COG4133	protoheme IX ABC transporter activity
PU02_RS02605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PU02_RS02610	COG0268	Binds directly to 16S ribosomal RNA
PU02_RS02615	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PU02_RS02630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PU02_RS02635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PU02_RS02640	COG1845	cytochrome c oxidase, subunit III
PU02_RS02645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PU02_RS02650	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PU02_RS02660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PU02_RS02675	COG0791	NLP P60 protein
PU02_RS02680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PU02_RS02685	COG1072	(Pantothenic acid kinase))
PU02_RS02690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PU02_RS02695	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PU02_RS02700	COG1185	polyribonucleotide nucleotidyltransferase activity
PU02_RS02705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PU02_RS02715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PU02_RS02720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PU02_RS02725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PU02_RS02735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PU02_RS02735	COG0195	Participates in both transcription termination and antitermination
PU02_RS02740	COG0779	Required for maturation of 30S ribosomal subunits
PU02_RS02745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PU02_RS02750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PU02_RS02755	COG1396	sequence-specific DNA binding
PU02_RS02760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PU02_RS02770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PU02_RS02775	COG1702	phosphate starvation-inducible protein PhoH
PU02_RS02780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PU02_RS02790	COG1214	PFAM Peptidase M22, glycoprotease
PU02_RS02795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PU02_RS02800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PU02_RS02810	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PU02_RS02815	COG3474	cytochrome
PU02_RS02820	COG4174	ABC transporter (Permease)
PU02_RS02825	COG4239	(ABC) transporter, permease
PU02_RS02830	COG4172	Belongs to the ABC transporter superfamily
PU02_RS02840	COG0189	ligase activity
PU02_RS02865	COG3561	AntA/AntB antirepressor
PU02_RS02990	COG0573	inorganic phosphate transmembrane transporter activity
PU02_RS03000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PU02_RS03005	COG0704	Plays a role in the regulation of phosphate uptake
PU02_RS03020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PU02_RS03035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PU02_RS03040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
PU02_RS03045	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PU02_RS03050	COG0590	tRNA wobble adenosine to inosine editing
PU02_RS03060	COG0742	ribosomal rna small subunit methyltransferase
PU02_RS03065	COG0312	modulator of DNA gyrase
PU02_RS03070	COG0483	inositol monophosphate 1-phosphatase activity
PU02_RS03085	COG1519	Transferase
PU02_RS03090	COG1663	tetraacyldisaccharide 4'-kinase activity
PU02_RS03095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PU02_RS03100	COG0717	Belongs to the dCTP deaminase family
PU02_RS03110	COG1113	amino acid transport
PU02_RS03115	COG1122	ATPase activity
PU02_RS03120	COG1113	amino acid transport
PU02_RS03125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PU02_RS03130	COG1268	BioY protein
PU02_RS03165	COG3561	AntA/AntB antirepressor
PU02_RS03250	COG2948	multi-organism process
PU02_RS03300	COG3646	Phage regulatory protein
PU02_RS03335	COG0588	phosphoglycerate mutase activity
PU02_RS03340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PU02_RS03350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PU02_RS03360	COG0594	ribonuclease P activity
PU02_RS03365	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PU02_RS03370	COG0489	protein tyrosine kinase activity
PU02_RS03380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PU02_RS03385	COG0792	nuclease activity
PU02_RS03405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PU02_RS03410	COG2086	electron transfer activity
PU02_RS03425	COG1570	exodeoxyribonuclease VII activity
PU02_RS03430	COG2818	Glycosylase
PU02_RS03435	COG0747	negative chemotaxis
PU02_RS03440	COG0747	negative chemotaxis
PU02_RS03445	COG0601	transmembrane transport
PU02_RS03450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PU02_RS03460	COG4608	Belongs to the ABC transporter superfamily
PU02_RS03510	COG0482	sulfurtransferase activity
PU02_RS03520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PU02_RS03550	COG0714	Associated with various cellular activities
PU02_RS03555	COG0617	tRNA 3'-terminal CCA addition
PU02_RS03560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PU02_RS03565	COG0012	GTP binding
PU02_RS03570	COG1376	ErfK ybiS ycfS ynhG family protein
PU02_RS03575	COG0193	aminoacyl-tRNA hydrolase activity
PU02_RS03580	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PU02_RS03585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PU02_RS03600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PU02_RS03615	COG2205	protein histidine kinase activity
PU02_RS03620	COG0745	RESPONSE REGULATOR receiver
PU02_RS03625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PU02_RS03635	COG0556	nucleotide-excision repair
PU02_RS03640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PU02_RS03650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PU02_RS03655	COG0492	ferredoxin-NADP+ reductase activity
PU02_RS03660	COG0583	DNA-binding transcription factor activity
PU02_RS03665	COG0436	Aminotransferase
PU02_RS03670	COG1278	Cold shock
PU02_RS03685	COG0505	Belongs to the CarA family
PU02_RS03695	COG0668	transmembrane transport
PU02_RS03705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PU02_RS03715	COG2968	Membrane
PU02_RS03735	COG1335	isochorismatase
PU02_RS03750	COG0275	rRNA processing
PU02_RS03775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PU02_RS03780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PU02_RS03790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PU02_RS03795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PU02_RS03800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PU02_RS03805	COG1181	Belongs to the D-alanine--D-alanine ligase family
PU02_RS03815	COG0849	cell division
PU02_RS03830	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PU02_RS03835	COG0497	DNA recombination
PU02_RS03840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PU02_RS03845	COG0006	proline dipeptidase activity
PU02_RS03850	COG2264	protein methyltransferase activity
PU02_RS03855	COG1999	signal sequence binding
PU02_RS03885	COG0477	Major facilitator Superfamily
PU02_RS03890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PU02_RS03905	COG0330	HflC and HflK could
PU02_RS03915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PU02_RS03920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PU02_RS03930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PU02_RS03935	COG1113	amino acid transport
PU02_RS03945	COG1253	flavin adenine dinucleotide binding
PU02_RS03950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PU02_RS03950	COG0392	lysyltransferase activity
PU02_RS03970	COG0513	Belongs to the DEAD box helicase family
PU02_RS03990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PU02_RS04005	COG0525	valine-tRNA ligase activity
PU02_RS04010	COG1126	abc transporter atp-binding protein
PU02_RS04015	COG0765	amino acid transport
PU02_RS04020	COG0765	amino acid transport
PU02_RS04035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PU02_RS04040	COG0049	tRNA binding
PU02_RS04045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PU02_RS04050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PU02_RS04055	COG0051	transcription antitermination factor activity, RNA binding
PU02_RS04060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PU02_RS04065	COG0088	Forms part of the polypeptide exit tunnel
PU02_RS04075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PU02_RS04080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PU02_RS04090	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PU02_RS04095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PU02_RS04100	COG0255	Belongs to the universal ribosomal protein uL29 family
PU02_RS04105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PU02_RS04110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PU02_RS04115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PU02_RS04120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PU02_RS04125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PU02_RS04130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PU02_RS04135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PU02_RS04140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PU02_RS04145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PU02_RS04150	COG1841	ribosomal large subunit assembly
PU02_RS04155	COG0200	Binds to the 23S rRNA
PU02_RS04160	COG0201	protein transport
PU02_RS04165	COG0563	adenylate kinase activity
PU02_RS04170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PU02_RS04175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PU02_RS04180	COG0202	RNA polymerase activity
PU02_RS04185	COG0203	ribosomal protein L17
PU02_RS04195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PU02_RS04200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PU02_RS04205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PU02_RS04210	COG1132	(ABC) transporter
PU02_RS04225	COG0174	glutamine synthetase
PU02_RS04240	COG0629	single-stranded DNA binding
PU02_RS04245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PU02_RS04250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PU02_RS04265	COG0343	queuine tRNA-ribosyltransferase activity
PU02_RS04275	COG0538	isocitrate dehydrogenase activity
PU02_RS04285	COG1494	fructose-1,6-bisphosphatase
PU02_RS04290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PU02_RS04300	COG0018	arginyl-trna synthetase
PU02_RS04305	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PU02_RS04310	COG0316	Belongs to the HesB IscA family
PU02_RS04320	COG0785	Cytochrome C biogenesis protein
PU02_RS04325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PU02_RS04330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PU02_RS04335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PU02_RS04355	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
PU02_RS04360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PU02_RS04365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PU02_RS04370	COG2814	Major facilitator Superfamily
PU02_RS04385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PU02_RS04390	COG0047	phosphoribosylformylglycinamidine synthase activity
PU02_RS04395	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PU02_RS04400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PU02_RS04410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PU02_RS04420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PU02_RS04435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PU02_RS04445	COG1522	sequence-specific DNA binding
PU02_RS04455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PU02_RS04460	COG0557	exoribonuclease II activity
PU02_RS04465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PU02_RS04470	COG0758	DNA mediated transformation
PU02_RS04475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PU02_RS04485	COG0540	Belongs to the ATCase OTCase family
PU02_RS04495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PU02_RS04500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PU02_RS04505	COG0154	amidase activity
PU02_RS04510	COG1278	Cold shock
PU02_RS04520	COG0596	Alpha beta hydrolase
PU02_RS04530	COG2003	Belongs to the UPF0758 family
PU02_RS04535	COG0024	Methionine aminopeptidase
PU02_RS04545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PU02_RS04550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PU02_RS04555	COG0037	tRNA processing
PU02_RS04570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PU02_RS04585	COG0084	hydrolase, TatD family'
PU02_RS04590	COG0321	lipoyl(octanoyl) transferase activity
PU02_RS04590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PU02_RS04595	COG1183	phosphatidylcholine synthase activity
PU02_RS04600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PU02_RS04610	COG2032	superoxide dismutase activity
PU02_RS04615	COG2151	metal-sulfur cluster biosynthetic enzyme
PU02_RS04620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PU02_RS04625	COG0719	Fe-S assembly protein
PU02_RS04630	COG0396	ATPase activity
PU02_RS04635	COG0719	Fe-S assembly protein
PU02_RS04645	COG2945	thiolester hydrolase activity
PU02_RS04650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PU02_RS04655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PU02_RS04665	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PU02_RS04670	COG0860	N-Acetylmuramoyl-L-alanine amidase
PU02_RS04675	COG1530	ribonuclease E activity
PU02_RS04685	COG4166	transmembrane transport
PU02_RS04690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PU02_RS04695	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PU02_RS04700	COG1136	(ABC) transporter
PU02_RS04710	COG0442	prolyl-tRNA aminoacylation
PU02_RS04725	COG1007	ATP synthesis coupled electron transport
PU02_RS04740	COG0713	ATP synthesis coupled electron transport
PU02_RS04750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PU02_RS04755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PU02_RS04765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PU02_RS04770	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PU02_RS04775	COG0649	NAD binding
PU02_RS04780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PU02_RS04785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PU02_RS04790	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PU02_RS04810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PU02_RS04815	COG0321	lipoyl(octanoyl) transferase activity
PU02_RS04820	COG0187	DNA topoisomerase II activity
PU02_RS04830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PU02_RS04835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PU02_RS04845	COG3023	N-Acetylmuramoyl-L-alanine amidase
PU02_RS04870	COG0628	permease
PU02_RS04875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PU02_RS04880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PU02_RS04890	COG0511	ligase activity, forming carbon-carbon bonds
PU02_RS04915	COG0302	gtp cyclohydrolase
PU02_RS04925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PU02_RS04930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PU02_RS04940	COG0776	regulation of translation
PU02_RS04945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PU02_RS04950	COG0416	fatty acid biosynthetic process
PU02_RS04965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PU02_RS04970	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PU02_RS04980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PU02_RS04980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PU02_RS04985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PU02_RS04990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PU02_RS05000	COG1612	heme a metabolic process
PU02_RS05005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PU02_RS05010	COG1923	regulation of RNA biosynthetic process
PU02_RS05020	COG0281	malic enzyme
PU02_RS05020	COG0280	phosphate acetyltransferase
PU02_RS05025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PU02_RS05030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PU02_RS05035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PU02_RS05040	COG1063	alcohol dehydrogenase
PU02_RS05060	COG0071	Belongs to the small heat shock protein (HSP20) family
PU02_RS05090	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
PU02_RS05090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PU02_RS05110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PU02_RS05115	COG2333	competence protein COMEC
PU02_RS05115	COG0658	competence protein
PU02_RS05120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PU02_RS05125	COG0372	Belongs to the citrate synthase family
PU02_RS05135	COG4215	(ABC) transporter
PU02_RS05145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PU02_RS05150	COG3494	Protein of unknown function (DUF1009)
PU02_RS05155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PU02_RS05160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PU02_RS05165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PU02_RS05175	COG0750	zinc metalloprotease
PU02_RS05185	COG0233	cytoplasmic translational termination
PU02_RS05190	COG0528	UMP kinase activity
PU02_RS05195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PU02_RS05200	COG0052	Belongs to the universal ribosomal protein uS2 family
PU02_RS05225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PU02_RS05230	COG1686	Belongs to the peptidase S11 family
PU02_RS05235	COG1760	l-serine dehydratase
PU02_RS05245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PU02_RS05250	COG0085	RNA polymerase activity
PU02_RS05255	COG0222	ribosome binding
PU02_RS05260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PU02_RS05265	COG0081	regulation of translation
PU02_RS05270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PU02_RS05290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PU02_RS05305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PU02_RS05320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PU02_RS05325	COG0544	peptidyl-prolyl cis-trans isomerase activity
PU02_RS05350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PU02_RS05355	COG0740	serine-type endopeptidase activity
PU02_RS05360	COG0569	domain protein
PU02_RS05365	COG2204	response regulator
PU02_RS05370	COG5000	phosphorelay sensor kinase activity
PU02_RS05375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PU02_RS05375	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PU02_RS05380	COG2867	negative regulation of translational initiation
PU02_RS05385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PU02_RS05390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PU02_RS05395	COG0508	dehydrogenase complex catalyzes the overall conversion of
PU02_RS05400	COG0022	dehydrogenase e1 component
PU02_RS05400	COG0508	dehydrogenase complex catalyzes the overall conversion of
PU02_RS05405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PU02_RS05415	COG0148	phosphopyruvate hydratase activity
PU02_RS05420	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PU02_RS05425	COG0504	CTP synthase activity
PU02_RS05430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PU02_RS05435	COG0149	triose-phosphate isomerase activity
PU02_RS05440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PU02_RS05445	COG1562	ergosterol biosynthetic process
PU02_RS05455	COG1862	Preprotein translocase
PU02_RS05460	COG1388	LysM domain
PU02_RS05460	COG0739	heme binding
PU02_RS05465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PU02_RS05470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PU02_RS05475	COG0805	protein transport
PU02_RS05480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PU02_RS05485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PU02_RS05490	COG1472	Belongs to the glycosyl hydrolase 3 family
PU02_RS05495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PU02_RS05500	COG0322	excinuclease ABC activity
PU02_RS05505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PU02_RS05510	COG0105	UTP biosynthetic process
PU02_RS05545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PU02_RS05550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PU02_RS05555	COG0194	GDP metabolic process
PU02_RS05560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PU02_RS05565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PU02_RS05570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PU02_RS05580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PU02_RS05585	COG0671	phosphoesterase, PA-phosphatase related
PU02_RS05590	COG0360	Binds together with S18 to 16S ribosomal RNA
PU02_RS05605	COG0359	binds to the 23S rRNA
PU02_RS05625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PU02_RS05630	COG1028	Short-chain dehydrogenase reductase Sdr
PU02_RS05635	COG1183	phosphatidylcholine synthase activity
PU02_RS05640	COG0688	phosphatidylethanolamine metabolic process
PU02_RS05645	COG5265	(ABC) transporter
PU02_RS05650	COG0215	cysteine-tRNA ligase activity
PU02_RS05655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PU02_RS05660	COG0354	folic acid binding
PU02_RS05665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PU02_RS05670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PU02_RS05675	COG1381	Involved in DNA repair and RecF pathway recombination
PU02_RS05685	COG0571	ribonuclease III activity
PU02_RS05690	COG0681	Belongs to the peptidase S26 family
PU02_RS05695	COG0736	holo-[acyl-carrier-protein] synthase activity
PU02_RS05705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PU02_RS05715	COG1758	RNA polymerase activity
PU02_RS05720	COG1573	uracil-dna glycosylase
PU02_RS05725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PU02_RS05730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PU02_RS05735	COG0741	lytic transglycosylase activity
PU02_RS05745	COG1629	transport
PU02_RS05745	COG4771	TonB-dependent receptor
PU02_RS05750	COG3720	iron ion transport
PU02_RS05755	COG4558	Periplasmic binding protein
PU02_RS05765	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PU02_RS05785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PU02_RS05800	COG2022	thiamine diphosphate biosynthetic process
PU02_RS05820	COG0308	aminopeptidase N
PU02_RS05825	COG2202	Pas domain
PU02_RS05825	COG2205	protein histidine kinase activity
PU02_RS05830	COG2205	protein histidine kinase activity
PU02_RS05835	COG0745	RESPONSE REGULATOR receiver
PU02_RS05840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PU02_RS05845	COG3088	subunit of a heme lyase
PU02_RS05850	COG1138	Cytochrome C-type biogenesis protein
PU02_RS05855	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PU02_RS05875	COG2166	iron-sulfur cluster assembly
PU02_RS05880	COG4957	zinc ion binding
PU02_RS05890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PU02_RS05900	COG0574	Belongs to the PEP-utilizing enzyme family
PU02_RS05900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PU02_RS05915	COG1194	a g-specific adenine glycosylase
PU02_RS05920	COG2189	Belongs to the N(4) N(6)-methyltransferase family
PU02_RS05930	COG0612	Peptidase, M16
PU02_RS05940	COG1678	Uncharacterized ACR, COG1678
PU02_RS05950	COG0328	RNA-DNA hybrid ribonuclease activity
PU02_RS05955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PU02_RS05970	COG0312	modulator of DNA gyrase
PU02_RS05985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PU02_RS05990	COG1722	exodeoxyribonuclease VII activity
PU02_RS05995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PU02_RS05995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PU02_RS06000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PU02_RS06005	COG0484	heat shock protein binding
PU02_RS06010	COG0259	pyridoxamine-phosphate oxidase activity
PU02_RS06030	COG0277	FAD linked oxidase domain protein
PU02_RS06035	COG0009	L-threonylcarbamoyladenylate synthase
PU02_RS06040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PU02_RS06045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PU02_RS06060	COG0142	geranyltranstransferase activity
PU02_RS06070	COG0752	glycyl-tRNA synthetase alpha subunit
PU02_RS06075	COG0751	glycine-tRNA ligase activity
PU02_RS06080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PU02_RS06085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PU02_RS06090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PU02_RS06095	COG0356	it plays a direct role in the translocation of protons across the membrane
PU02_RS06105	COG1160	GTP binding
PU02_RS06120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PU02_RS06130	COG0527	aspartate kinase activity
PU02_RS06135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PU02_RS06140	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PU02_RS06145	COG1040	competence protein
PU02_RS06150	COG2226	methyltransferase
PU02_RS06155	COG1823	symporter activity
PU02_RS06160	COG0494	nUDIX hydrolase
PU02_RS06165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PU02_RS06170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PU02_RS06180	COG0653	protein targeting
PU02_RS06190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PU02_RS06195	COG2890	protein-(glutamine-N5) methyltransferase activity
PU02_RS06205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PU02_RS06210	COG1780	Probably involved in ribonucleotide reductase function
PU02_RS06220	COG1121	(ABC) transporter
PU02_RS06230	COG0803	Belongs to the bacterial solute-binding protein 9 family
PU02_RS06245	COG0395	ABC-type sugar transport system, permease component
PU02_RS06250	COG3842	ATPase activity
PU02_RS06260	COG0519	Catalyzes the synthesis of GMP from XMP
PU02_RS06260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PU02_RS06265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PU02_RS06265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PU02_RS06285	COG0517	IMP dehydrogenase activity
PU02_RS06285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PU02_RS06290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PU02_RS06295	COG2951	lytic endotransglycosylase activity
PU02_RS06300	COG0339	signal peptide processing
PU02_RS06305	COG2239	Acts as a magnesium transporter
PU02_RS06310	COG1217	gtp-binding protein TYPA
PU02_RS06315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PU02_RS06320	COG1872	DUF167
PU02_RS06330	COG5342	invasion associated locus B
PU02_RS06335	COG0494	nUDIX hydrolase
PU02_RS06340	COG0793	Belongs to the peptidase S41A family
PU02_RS06350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PU02_RS06355	COG0799	negative regulation of ribosome biogenesis
PU02_RS06360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PU02_RS06365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PU02_RS06370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PU02_RS06375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PU02_RS06380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit