locus-tag	class	description
BBC0178_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BBC0178_RS00010	COG0424	maF-like protein
BBC0178_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BBC0178_RS00020	COG0237	dephospho-CoA kinase activity
BBC0178_RS00025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBC0178_RS00030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBC0178_RS00030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBC0178_RS00045	COG0137	argininosuccinate synthase activity
BBC0178_RS00055	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBC0178_RS00070	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBC0178_RS00075	COG2096	Adenosyltransferase
BBC0178_RS00085	COG1671	Belongs to the UPF0178 family
BBC0178_RS00090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBC0178_RS00105	COG0019	diaminopimelate decarboxylase activity
BBC0178_RS00120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBC0178_RS00135	COG2226	methyltransferase
BBC0178_RS00145	COG0745	RESPONSE REGULATOR receiver
BBC0178_RS00155	COG0825	malonyl-CoA metabolic process
BBC0178_RS00160	COG4974	Belongs to the 'phage' integrase family
BBC0178_RS00175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BBC0178_RS00180	COG1686	Belongs to the peptidase S11 family
BBC0178_RS00185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BBC0178_RS00190	COG0181	hydroxymethylbilane synthase activity
BBC0178_RS00195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBC0178_RS00205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BBC0178_RS00210	COG1420	regulation of RNA biosynthetic process
BBC0178_RS00220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BBC0178_RS00225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BBC0178_RS00230	COG0346	lactoylglutathione lyase activity
BBC0178_RS00235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBC0178_RS00235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BBC0178_RS00240	COG4770	biotin carboxylase activity
BBC0178_RS00245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBC0178_RS00250	COG1396	sequence-specific DNA binding
BBC0178_RS00250	COG3800	Transcriptional regulator
BBC0178_RS00255	COG0667	Aldo Keto reductase
BBC0178_RS00260	COG0583	DNA-binding transcription factor activity
BBC0178_RS00270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BBC0178_RS00280	COG0697	spore germination
BBC0178_RS00285	COG0481	GTPase activity
BBC0178_RS00295	COG2171	N-acyltransferase activity
BBC0178_RS00310	COG0443	Heat shock 70 kDa protein
BBC0178_RS00315	COG0484	heat shock protein binding
BBC0178_RS00320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBC0178_RS00330	COG1473	amidohydrolase
BBC0178_RS00335	COG1473	amidohydrolase
BBC0178_RS00345	COG1473	amidohydrolase
BBC0178_RS00350	COG1376	ErfK ybiS ycfS ynhG family protein
BBC0178_RS00360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BBC0178_RS00375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BBC0178_RS00380	COG0531	amino acid
BBC0178_RS00395	COG1132	(ABC) transporter
BBC0178_RS00400	COG0604	alcohol dehydrogenase
BBC0178_RS00410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BBC0178_RS00415	COG1072	(Pantothenic acid kinase))
BBC0178_RS00430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BBC0178_RS00440	COG0131	Imidazoleglycerol-phosphate dehydratase
BBC0178_RS00445	COG0252	asparaginase activity
BBC0178_RS00450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BBC0178_RS00455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BBC0178_RS00460	COG2855	membrane
BBC0178_RS00465	COG0583	DNA-binding transcription factor activity
BBC0178_RS00480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BBC0178_RS00490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BBC0178_RS00490	COG0116	Belongs to the methyltransferase superfamily
BBC0178_RS00520	COG1137	ATPase activity
BBC0178_RS00525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BBC0178_RS00530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBC0178_RS00535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBC0178_RS00585	COG0606	chelatase, subunit chli
BBC0178_RS00590	COG0729	surface antigen
BBC0178_RS00605	COG1216	Glycosyl transferase, family 2
BBC0178_RS00605	COG0463	Glycosyl transferase, family 2
BBC0178_RS00610	COG0438	transferase activity, transferring glycosyl groups
BBC0178_RS00640	COG0673	inositol 2-dehydrogenase activity
BBC0178_RS00650	COG1091	dTDP-4-dehydrorhamnose reductase activity
BBC0178_RS00655	COG1088	dTDP-glucose 4,6-dehydratase activity
BBC0178_RS00675	COG2205	protein histidine kinase activity
BBC0178_RS00680	COG0802	atpase or kinase
BBC0178_RS00685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BBC0178_RS00690	COG2887	Belongs to the helicase family. UvrD subfamily
BBC0178_RS00695	COG1074	ATP-dependent DNA helicase activity
BBC0178_RS00710	COG1396	sequence-specific DNA binding
BBC0178_RS00715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BBC0178_RS00755	COG1652	LysM domain
BBC0178_RS00770	COG0745	RESPONSE REGULATOR receiver
BBC0178_RS00775	COG2205	protein histidine kinase activity
BBC0178_RS00785	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBC0178_RS00785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBC0178_RS00790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBC0178_RS00795	COG2860	membrane
BBC0178_RS00800	COG2130	NADP-dependent
BBC0178_RS00805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBC0178_RS00810	COG2326	polyphosphate kinase activity
BBC0178_RS00815	COG0101	tRNA pseudouridine synthase activity
BBC0178_RS00820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BBC0178_RS00825	COG0242	peptide deformylase activity
BBC0178_RS00850	COG0697	spore germination
BBC0178_RS00895	COG0071	Belongs to the small heat shock protein (HSP20) family
BBC0178_RS00910	COG2169	Transcriptional regulator
BBC0178_RS00910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BBC0178_RS00915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BBC0178_RS00920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BBC0178_RS00930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BBC0178_RS00935	COG0072	phenylalanine-tRNA ligase activity
BBC0178_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBC0178_RS00965	COG0702	epimerase
BBC0178_RS00970	COG0285	dihydrofolate synthase activity
BBC0178_RS00975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BBC0178_RS00980	COG0159	tryptophan synthase activity
BBC0178_RS00985	COG0133	tryptophan synthase activity
BBC0178_RS01000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBC0178_RS01005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BBC0178_RS01010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BBC0178_RS01015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBC0178_RS01020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BBC0178_RS01030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BBC0178_RS01055	COG1121	(ABC) transporter
BBC0178_RS01060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBC0178_RS01065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBC0178_RS01080	COG1388	LysM domain
BBC0178_RS01080	COG1376	ErfK ybiS ycfS ynhG family protein
BBC0178_RS01085	COG2832	Protein of unknown function (DUF454)
BBC0178_RS01100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBC0178_RS01115	COG0670	Belongs to the BI1 family
BBC0178_RS01125	COG4181	ATPase activity
BBC0178_RS01140	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BBC0178_RS01150	COG1643	Atp-dependent helicase
BBC0178_RS01160	COG0251	oxidation-reduction process
BBC0178_RS01180	COG3459	Glycosyltransferase 36 associated
BBC0178_RS01185	COG0280	phosphate acetyltransferase
BBC0178_RS01185	COG0281	malic enzyme
BBC0178_RS01190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BBC0178_RS01200	COG0183	Belongs to the thiolase family
BBC0178_RS01205	COG0318	PFAM AMP-dependent synthetase and ligase
BBC0178_RS01210	COG0129	dihydroxy-acid dehydratase activity
BBC0178_RS01215	COG0778	Nitroreductase
BBC0178_RS01235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BBC0178_RS01240	COG0539	negative regulation of cytoplasmic translation
BBC0178_RS01245	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BBC0178_RS01250	COG3030	protein affecting phage T7 exclusion by the F plasmid
BBC0178_RS01270	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BBC0178_RS01285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBC0178_RS01295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBC0178_RS01310	COG0189	ligase activity
BBC0178_RS01315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBC0178_RS01325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBC0178_RS01330	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBC0178_RS01335	COG4133	protoheme IX ABC transporter activity
BBC0178_RS01340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BBC0178_RS01345	COG0268	Binds directly to 16S ribosomal RNA
BBC0178_RS01350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BBC0178_RS01365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBC0178_RS01370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BBC0178_RS01375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BBC0178_RS01380	COG1845	cytochrome c oxidase, subunit III
BBC0178_RS01385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BBC0178_RS01405	COG1214	PFAM Peptidase M22, glycoprotease
BBC0178_RS01415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBC0178_RS01420	COG1702	phosphate starvation-inducible protein PhoH
BBC0178_RS01425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BBC0178_RS01430	COG4535	Mg2 and Co2 transporter CorC
BBC0178_RS01435	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BBC0178_RS01445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BBC0178_RS01450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BBC0178_RS01455	COG0779	Required for maturation of 30S ribosomal subunits
BBC0178_RS01460	COG0195	Participates in both transcription termination and antitermination
BBC0178_RS01460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BBC0178_RS01470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BBC0178_RS01480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BBC0178_RS01500	COG1185	polyribonucleotide nucleotidyltransferase activity
BBC0178_RS01505	COG2813	Specifically methylates the guanine in position
BBC0178_RS01510	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BBC0178_RS01520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BBC0178_RS01555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BBC0178_RS01570	COG2816	NAD+ diphosphatase activity
BBC0178_RS01575	COG0077	Prephenate dehydratase
BBC0178_RS01575	COG1605	Chorismate mutase
BBC0178_RS01580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BBC0178_RS01585	COG3474	cytochrome
BBC0178_RS01590	COG4166	transmembrane transport
BBC0178_RS01595	COG4174	ABC transporter (Permease)
BBC0178_RS01600	COG4239	(ABC) transporter, permease
BBC0178_RS01605	COG4172	Belongs to the ABC transporter superfamily
BBC0178_RS01620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BBC0178_RS01625	COG0189	ligase activity
BBC0178_RS01635	COG0573	inorganic phosphate transmembrane transporter activity
BBC0178_RS01645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BBC0178_RS01650	COG0704	Plays a role in the regulation of phosphate uptake
BBC0178_RS01665	COG4993	Dehydrogenase
BBC0178_RS01675	COG0717	Belongs to the dCTP deaminase family
BBC0178_RS01685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BBC0178_RS01695	COG1663	tetraacyldisaccharide 4'-kinase activity
BBC0178_RS01700	COG1519	Transferase
BBC0178_RS01705	COG2121	Domain of unknown function (DUF374)
BBC0178_RS01715	COG0483	inositol monophosphate 1-phosphatase activity
BBC0178_RS01720	COG0312	modulator of DNA gyrase
BBC0178_RS01725	COG0612	Peptidase, M16
BBC0178_RS01730	COG0612	Peptidase, M16
BBC0178_RS01735	COG0742	ribosomal rna small subunit methyltransferase
BBC0178_RS01745	COG0590	tRNA wobble adenosine to inosine editing
BBC0178_RS01750	COG0656	L-ascorbic acid biosynthetic process
BBC0178_RS01765	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BBC0178_RS01770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BBC0178_RS01780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBC0178_RS01785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBC0178_RS01790	COG2309	aminopeptidase activity
BBC0178_RS01795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBC0178_RS01800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BBC0178_RS01810	COG2181	nitrate reductase activity
BBC0178_RS01815	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BBC0178_RS01825	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BBC0178_RS01845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBC0178_RS01850	COG2900	Belongs to the SlyX family
BBC0178_RS01880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBC0178_RS01900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBC0178_RS01930	COG3938	Belongs to the proline racemase family
BBC0178_RS01935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBC0178_RS01940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBC0178_RS01955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBC0178_RS01965	COG0765	amino acid transport
BBC0178_RS01970	COG0765	amino acid transport
BBC0178_RS01975	COG1126	abc transporter atp-binding protein
BBC0178_RS01990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BBC0178_RS02005	COG0732	type I restriction modification DNA specificity domain
BBC0178_RS02010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BBC0178_RS02020	COG2204	response regulator
BBC0178_RS02025	COG3852	Histidine kinase
BBC0178_RS02055	COG3848	Pyruvate phosphate dikinase
BBC0178_RS02055	COG0574	Belongs to the PEP-utilizing enzyme family
BBC0178_RS02075	COG0318	PFAM AMP-dependent synthetase and ligase
BBC0178_RS02145	COG3842	ATPase activity
BBC0178_RS02155	COG1349	DNA-binding transcription factor activity
BBC0178_RS02160	COG2271	Major facilitator Superfamily
BBC0178_RS02165	COG0583	DNA-binding transcription factor activity
BBC0178_RS02190	COG1012	belongs to the aldehyde dehydrogenase family
BBC0178_RS02225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BBC0178_RS02230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBC0178_RS02235	COG1116	anion transmembrane transporter activity
BBC0178_RS02245	COG1064	alcohol dehydrogenase
BBC0178_RS02260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BBC0178_RS02295	COG0745	RESPONSE REGULATOR receiver
BBC0178_RS02300	COG2205	protein histidine kinase activity
BBC0178_RS02315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBC0178_RS02320	COG0505	Belongs to the CarA family
BBC0178_RS02335	COG2086	electron transfer activity
BBC0178_RS02340	COG0667	Aldo Keto reductase
BBC0178_RS02350	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BBC0178_RS02360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBC0178_RS02375	COG0730	response to heat
BBC0178_RS02395	COG1201	RNA secondary structure unwinding
BBC0178_RS02405	COG2340	Cysteine-rich secretory protein family
BBC0178_RS02420	COG0519	Catalyzes the synthesis of GMP from XMP
BBC0178_RS02435	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BBC0178_RS02455	COG0033	Phosphoglucomutase
BBC0178_RS02465	COG0459	protein refolding
BBC0178_RS02470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BBC0178_RS02485	COG3920	Histidine kinase
BBC0178_RS02490	COG0180	Tryptophanyl-tRNA synthetase
BBC0178_RS02495	COG0728	peptidoglycan biosynthetic process
BBC0178_RS02510	COG0196	riboflavin kinase activity
BBC0178_RS02525	COG0431	NADPH-dependent FMN reductase
BBC0178_RS02540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BBC0178_RS02545	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BBC0178_RS02550	COG1684	flagellar biosynthetic protein fliR
BBC0178_RS02585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BBC0178_RS02590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BBC0178_RS02595	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BBC0178_RS02610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BBC0178_RS02620	COG4786	Flagellar basal body rod
BBC0178_RS02625	COG1157	protein secretion by the type III secretion system
BBC0178_RS02640	COG1815	bacterial-type flagellum-dependent cell motility
BBC0178_RS02645	COG1558	bacterial-type flagellum-dependent cell motility
BBC0178_RS02655	COG1677	Flagellar hook-basal body complex protein FliE
BBC0178_RS02660	COG4786	Flagellar basal body rod
BBC0178_RS02665	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
BBC0178_RS02670	COG1706	bacterial-type flagellum-dependent cell motility
BBC0178_RS02680	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BBC0178_RS02690	COG1338	Plays a role in the flagellum-specific transport system
BBC0178_RS02725	COG1360	Flagellar Motor Protein
BBC0178_RS02755	COG1256	bacterial-type flagellum assembly
BBC0178_RS02775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BBC0178_RS02810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BBC0178_RS02810	COG0248	Ppx GppA phosphatase
BBC0178_RS02825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BBC0178_RS02830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BBC0178_RS02835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BBC0178_RS02840	COG0799	negative regulation of ribosome biogenesis
BBC0178_RS02845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BBC0178_RS02855	COG0793	Belongs to the peptidase S41A family
BBC0178_RS02860	COG0494	nUDIX hydrolase
BBC0178_RS02865	COG5342	invasion associated locus B
BBC0178_RS02875	COG0789	Transcriptional regulator
BBC0178_RS02900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BBC0178_RS02905	COG1217	gtp-binding protein TYPA
BBC0178_RS02910	COG2239	Acts as a magnesium transporter
BBC0178_RS02915	COG0747	negative chemotaxis
BBC0178_RS02920	COG0339	signal peptide processing
BBC0178_RS02925	COG0066	3-isopropylmalate dehydratase activity
BBC0178_RS02940	COG2951	lytic endotransglycosylase activity
BBC0178_RS02945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BBC0178_RS02950	COG0517	IMP dehydrogenase activity
BBC0178_RS02950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BBC0178_RS02955	COG1012	belongs to the aldehyde dehydrogenase family
BBC0178_RS02965	COG0747	negative chemotaxis
BBC0178_RS02975	COG0601	transmembrane transport
BBC0178_RS02980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBC0178_RS02985	COG0444	Belongs to the ABC transporter superfamily
BBC0178_RS02990	COG4608	Belongs to the ABC transporter superfamily
BBC0178_RS02995	COG1063	alcohol dehydrogenase
BBC0178_RS03000	COG0753	catalase activity
BBC0178_RS03025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBC0178_RS03050	COG3189	MarR family transcriptional regulator
BBC0178_RS03055	COG0277	FAD linked oxidase domain protein
BBC0178_RS03060	COG0277	FAD linked oxidase domain protein
BBC0178_RS03080	COG2204	response regulator
BBC0178_RS03090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BBC0178_RS03095	COG0330	HflC and HflK could
BBC0178_RS03100	COG1585	Membrane protein implicated in regulation of membrane protease activity
BBC0178_RS03105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BBC0178_RS03105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBC0178_RS03120	COG0826	peptidase U32
BBC0178_RS03135	COG0642	Histidine kinase
BBC0178_RS03145	COG2194	sulfuric ester hydrolase activity
BBC0178_RS03165	COG0527	aspartate kinase activity
BBC0178_RS03170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BBC0178_RS03185	COG1040	competence protein
BBC0178_RS03190	COG2226	methyltransferase
BBC0178_RS03195	COG1823	symporter activity
BBC0178_RS03205	COG0494	nUDIX hydrolase
BBC0178_RS03215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BBC0178_RS03225	COG0653	protein targeting
BBC0178_RS03240	COG2890	protein-(glutamine-N5) methyltransferase activity
BBC0178_RS03245	COG2814	Major facilitator Superfamily
BBC0178_RS03255	COG1780	Probably involved in ribonucleotide reductase function
BBC0178_RS03260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBC0178_RS03280	COG1573	uracil-dna glycosylase
BBC0178_RS03290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBC0178_RS03315	COG0659	secondary active sulfate transmembrane transporter activity
BBC0178_RS03325	COG0471	metal ion transport
BBC0178_RS03325	COG3273	potassium ion transport
BBC0178_RS03340	COG1160	GTP binding
BBC0178_RS03360	COG0356	it plays a direct role in the translocation of protons across the membrane
BBC0178_RS03370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BBC0178_RS03375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BBC0178_RS03385	COG3781	membrane
BBC0178_RS03390	COG0751	glycine-tRNA ligase activity
BBC0178_RS03405	COG0142	geranyltranstransferase activity
BBC0178_RS03430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BBC0178_RS03435	COG0521	Mo-molybdopterin cofactor biosynthetic process
BBC0178_RS03455	COG0009	L-threonylcarbamoyladenylate synthase
BBC0178_RS03460	COG0277	FAD linked oxidase domain protein
BBC0178_RS03495	COG0484	heat shock protein binding
BBC0178_RS03510	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BBC0178_RS03535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBC0178_RS03535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBC0178_RS03540	COG1722	exodeoxyribonuclease VII activity
BBC0178_RS03545	COG0586	Pfam SNARE associated Golgi protein
BBC0178_RS03550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBC0178_RS03565	COG2391	methyltransferase activity
BBC0178_RS03570	COG0312	modulator of DNA gyrase
BBC0178_RS03580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BBC0178_RS03585	COG0109	protoheme IX farnesyltransferase activity
BBC0178_RS03590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BBC0178_RS03595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BBC0178_RS03610	COG1678	Uncharacterized ACR, COG1678
BBC0178_RS03615	COG3300	MHYT domain
BBC0178_RS03615	COG5001	Diguanylate cyclase
BBC0178_RS03625	COG0612	Peptidase, M16
BBC0178_RS03645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BBC0178_RS03650	COG1194	a g-specific adenine glycosylase
BBC0178_RS03670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBC0178_RS03675	COG1196	nuclear chromosome segregation
BBC0178_RS03680	COG0574	Belongs to the PEP-utilizing enzyme family
BBC0178_RS03680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBC0178_RS03715	COG0598	Magnesium transport protein CorA
BBC0178_RS03725	COG0433	COG0433 Predicted ATPase
BBC0178_RS03730	COG1376	ErfK ybiS ycfS ynhG family protein
BBC0178_RS03735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BBC0178_RS03755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBC0178_RS03765	COG2166	iron-sulfur cluster assembly
BBC0178_RS03775	COG2205	protein histidine kinase activity
BBC0178_RS03820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBC0178_RS03830	COG4235	cytochrome complex assembly
BBC0178_RS03835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BBC0178_RS03840	COG1138	Cytochrome C-type biogenesis protein
BBC0178_RS03845	COG3088	subunit of a heme lyase
BBC0178_RS03850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBC0178_RS03855	COG0745	RESPONSE REGULATOR receiver
BBC0178_RS03860	COG2205	protein histidine kinase activity
BBC0178_RS03865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BBC0178_RS03870	COG2202	Pas domain
BBC0178_RS03870	COG2205	protein histidine kinase activity
BBC0178_RS03875	COG0308	aminopeptidase N
BBC0178_RS03885	COG1573	uracil-dna glycosylase
BBC0178_RS03905	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BBC0178_RS03910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BBC0178_RS03910	COG0352	thiamine-phosphate diphosphorylase activity
BBC0178_RS03910	COG0351	phosphomethylpyrimidine kinase
BBC0178_RS03920	COG2022	thiamine diphosphate biosynthetic process
BBC0178_RS03940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BBC0178_RS03975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBC0178_RS03990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BBC0178_RS03995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBC0178_RS04000	COG4558	Periplasmic binding protein
BBC0178_RS04005	COG3720	iron ion transport
BBC0178_RS04025	COG0741	lytic transglycosylase activity
BBC0178_RS04030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBC0178_RS04035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BBC0178_RS04040	COG1573	uracil-dna glycosylase
BBC0178_RS04050	COG1758	RNA polymerase activity
BBC0178_RS04060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BBC0178_RS04065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBC0178_RS04070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BBC0178_RS04075	COG2223	nitrite transmembrane transporter activity
BBC0178_RS04085	COG0736	holo-[acyl-carrier-protein] synthase activity
BBC0178_RS04090	COG0681	Belongs to the peptidase S26 family
BBC0178_RS04095	COG0571	ribonuclease III activity
BBC0178_RS04120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BBC0178_RS04125	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BBC0178_RS04135	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BBC0178_RS04140	COG0354	folic acid binding
BBC0178_RS04145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBC0178_RS04175	COG0215	cysteine-tRNA ligase activity
BBC0178_RS04200	COG5265	(ABC) transporter
BBC0178_RS04205	COG0688	phosphatidylethanolamine metabolic process
BBC0178_RS04210	COG1183	phosphatidylcholine synthase activity
BBC0178_RS04220	COG4221	oxidoreductase activity
BBC0178_RS04225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BBC0178_RS04240	COG0305	Participates in initiation and elongation during chromosome replication
BBC0178_RS04265	COG0360	Binds together with S18 to 16S ribosomal RNA
BBC0178_RS04270	COG0671	phosphoesterase, PA-phosphatase related
BBC0178_RS04275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BBC0178_RS04290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBC0178_RS04295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BBC0178_RS04300	COG0028	Belongs to the TPP enzyme family
BBC0178_RS04305	COG0477	Major facilitator Superfamily
BBC0178_RS04315	COG1561	YicC-like family, N-terminal region
BBC0178_RS04320	COG0194	GDP metabolic process
BBC0178_RS04330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BBC0178_RS04340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BBC0178_RS04355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BBC0178_RS04375	COG0477	Major facilitator Superfamily
BBC0178_RS04385	COG0488	(ABC) transporter
BBC0178_RS04390	COG0105	UTP biosynthetic process
BBC0178_RS04400	COG0314	molybdopterin synthase activity
BBC0178_RS04410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBC0178_RS04435	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BBC0178_RS04450	COG0243	molybdopterin cofactor binding
BBC0178_RS04455	COG1472	Belongs to the glycosyl hydrolase 3 family
BBC0178_RS04465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BBC0178_RS04470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBC0178_RS04475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBC0178_RS04480	COG0805	protein transport
BBC0178_RS04490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BBC0178_RS04495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BBC0178_RS04500	COG4942	peptidase
BBC0178_RS04500	COG1388	LysM domain
BBC0178_RS04510	COG1862	Preprotein translocase
BBC0178_RS04530	COG0303	'Molybdopterin
BBC0178_RS04540	COG0134	indole-3-glycerol-phosphate synthase activity
BBC0178_RS04545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBC0178_RS04555	COG0149	triose-phosphate isomerase activity
BBC0178_RS04560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBC0178_RS04570	COG0504	CTP synthase activity
BBC0178_RS04590	COG2314	TM2 domain
BBC0178_RS04595	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BBC0178_RS04600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BBC0178_RS04605	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBC0178_RS04605	COG0022	dehydrogenase e1 component
BBC0178_RS04610	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBC0178_RS04620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBC0178_RS04625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BBC0178_RS04630	COG2867	negative regulation of translational initiation
BBC0178_RS04640	COG1546	Belongs to the CinA family
BBC0178_RS04640	COG1058	Belongs to the CinA family
BBC0178_RS04645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BBC0178_RS04645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BBC0178_RS04650	COG1959	2 iron, 2 sulfur cluster binding
BBC0178_RS04655	COG5000	phosphorelay sensor kinase activity
BBC0178_RS04660	COG2204	response regulator
BBC0178_RS04665	COG0569	domain protein
BBC0178_RS04675	COG0740	serine-type endopeptidase activity
BBC0178_RS04680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BBC0178_RS04700	COG0546	phosphoglycolate phosphatase activity
BBC0178_RS04720	COG0544	peptidyl-prolyl cis-trans isomerase activity
BBC0178_RS04725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BBC0178_RS04740	COG4765	Protein conserved in bacteria
BBC0178_RS04750	COG1376	ErfK ybiS ycfS ynhG family protein
BBC0178_RS04765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBC0178_RS04780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBC0178_RS04795	COG0250	Participates in transcription elongation, termination and antitermination
BBC0178_RS04805	COG0081	regulation of translation
BBC0178_RS04815	COG0222	ribosome binding
BBC0178_RS04825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BBC0178_RS04840	COG0789	Transcriptional regulator
BBC0178_RS04855	COG1760	l-serine dehydratase
BBC0178_RS04870	COG1686	Belongs to the peptidase S11 family
BBC0178_RS04905	COG0052	Belongs to the universal ribosomal protein uS2 family
BBC0178_RS04910	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BBC0178_RS04915	COG0528	UMP kinase activity
BBC0178_RS04935	COG0750	zinc metalloprotease
BBC0178_RS04940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBC0178_RS04945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBC0178_RS04955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBC0178_RS04965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBC0178_RS04970	COG1126	abc transporter atp-binding protein
BBC0178_RS04975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBC0178_RS04990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBC0178_RS05005	COG1473	amidohydrolase
BBC0178_RS05025	COG0330	HflC and HflK could
BBC0178_RS05035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBC0178_RS05040	COG0560	Phosphoserine phosphatase
BBC0178_RS05045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BBC0178_RS05050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBC0178_RS05060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBC0178_RS05065	COG1183	phosphatidylcholine synthase activity
BBC0178_RS05080	COG2989	Protein conserved in bacteria
BBC0178_RS05100	COG1612	heme a metabolic process
BBC0178_RS05105	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BBC0178_RS05110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BBC0178_RS05115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBC0178_RS05120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBC0178_RS05120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBC0178_RS05130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BBC0178_RS05150	COG0416	fatty acid biosynthetic process
BBC0178_RS05155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BBC0178_RS05160	COG0776	regulation of translation
BBC0178_RS05195	COG0071	Belongs to the small heat shock protein (HSP20) family
BBC0178_RS05200	COG0070	glutamate synthase
BBC0178_RS05200	COG0067	glutamate synthase
BBC0178_RS05200	COG0069	glutamate synthase activity
BBC0178_RS05225	COG3956	TIGRFAM MazG family protein
BBC0178_RS05230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BBC0178_RS05250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBC0178_RS05260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBC0178_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
BBC0178_RS05280	COG1127	ABC transporter
BBC0178_RS05290	COG3218	ABC-type transport auxiliary lipoprotein component
BBC0178_RS05290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BBC0178_RS05305	COG0633	Ferredoxin
BBC0178_RS05315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BBC0178_RS05320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBC0178_RS05360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBC0178_RS05380	COG0028	Belongs to the TPP enzyme family
BBC0178_RS05385	COG0440	acetolactate synthase activity
BBC0178_RS05390	COG2070	2-Nitropropane dioxygenase
BBC0178_RS05395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBC0178_RS05405	COG0372	Belongs to the citrate synthase family
BBC0178_RS05430	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BBC0178_RS05445	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BBC0178_RS05465	COG0513	Belongs to the DEAD box helicase family
BBC0178_RS05485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BBC0178_RS05500	COG1530	ribonuclease E activity
BBC0178_RS05510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BBC0178_RS05525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BBC0178_RS05535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BBC0178_RS05540	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BBC0178_RS05545	COG2945	thiolester hydrolase activity
BBC0178_RS05555	COG0719	Fe-S assembly protein
BBC0178_RS05560	COG0396	ATPase activity
BBC0178_RS05565	COG0719	Fe-S assembly protein
BBC0178_RS05570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBC0178_RS05575	COG2151	metal-sulfur cluster biosynthetic enzyme
BBC0178_RS05580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBC0178_RS05595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BBC0178_RS05600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BBC0178_RS05610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BBC0178_RS05615	COG0187	DNA topoisomerase II activity
BBC0178_RS05650	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BBC0178_RS05655	COG1704	LemA family
BBC0178_RS05670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBC0178_RS05675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBC0178_RS05680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBC0178_RS05685	COG0649	NAD binding
BBC0178_RS05690	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BBC0178_RS05695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BBC0178_RS05705	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BBC0178_RS05710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBC0178_RS05720	COG0713	ATP synthesis coupled electron transport
BBC0178_RS05735	COG1007	ATP synthesis coupled electron transport
BBC0178_RS05740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BBC0178_RS05740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BBC0178_RS05760	COG1136	(ABC) transporter
BBC0178_RS05780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BBC0178_RS05790	COG4166	transmembrane transport
BBC0178_RS05800	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BBC0178_RS05815	COG1686	Belongs to the peptidase S11 family
BBC0178_RS05820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BBC0178_RS05825	COG0470	DNA polymerase III
BBC0178_RS05830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBC0178_RS05835	COG0084	hydrolase, TatD family'
BBC0178_RS05845	COG1120	ATPase activity
BBC0178_RS05850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBC0178_RS05860	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BBC0178_RS05865	COG4774	siderophore transport
BBC0178_RS05865	COG1629	transport
BBC0178_RS05890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BBC0178_RS05895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBC0178_RS05900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BBC0178_RS05910	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BBC0178_RS05915	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BBC0178_RS05920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBC0178_RS05940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BBC0178_RS05945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BBC0178_RS05965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BBC0178_RS05975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBC0178_RS05980	COG1126	abc transporter atp-binding protein
BBC0178_RS05985	COG0765	amino acid transport
BBC0178_RS05990	COG4597	amino acid ABC transporter
BBC0178_RS05995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBC0178_RS06000	COG0626	cystathionine gamma-synthase activity
BBC0178_RS06010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BBC0178_RS06020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBC0178_RS06025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BBC0178_RS06030	COG0785	Cytochrome C biogenesis protein
BBC0178_RS06045	COG2879	small protein
BBC0178_RS06050	COG1966	Carbon starvation protein
BBC0178_RS06070	COG2010	Cytochrome c
BBC0178_RS06075	COG3381	protein complex oligomerization
BBC0178_RS06105	COG0842	Transport permease protein
BBC0178_RS06110	COG0842	Transport permease protein
BBC0178_RS06110	COG1129	ABC transporter
BBC0178_RS06115	COG1129	ABC transporter
BBC0178_RS06115	COG0842	Transport permease protein
BBC0178_RS06120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBC0178_RS06145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BBC0178_RS06160	COG0316	Belongs to the HesB IscA family
BBC0178_RS06180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBC0178_RS06185	COG1494	fructose-1,6-bisphosphatase
BBC0178_RS06195	COG0436	Aminotransferase
BBC0178_RS06215	COG0129	dihydroxy-acid dehydratase activity
BBC0178_RS06225	COG0583	DNA-binding transcription factor activity
BBC0178_RS06295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BBC0178_RS06350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BBC0178_RS06360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBC0178_RS06375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BBC0178_RS06380	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBC0178_RS06395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBC0178_RS06405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BBC0178_RS06410	COG2814	Major facilitator Superfamily
BBC0178_RS06415	COG0037	tRNA processing
BBC0178_RS06420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BBC0178_RS06430	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BBC0178_RS06435	COG0024	Methionine aminopeptidase
BBC0178_RS06440	COG2003	Belongs to the UPF0758 family
BBC0178_RS06455	COG0596	Alpha beta hydrolase
BBC0178_RS06465	COG1278	Cold shock
BBC0178_RS06500	COG0154	amidase activity
BBC0178_RS06505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BBC0178_RS06520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BBC0178_RS06525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BBC0178_RS06535	COG0540	Belongs to the ATCase OTCase family
BBC0178_RS06540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBC0178_RS06545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BBC0178_RS06550	COG0758	DNA mediated transformation
BBC0178_RS06560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBC0178_RS06560	COG1754	DNA topoisomerase type I activity
BBC0178_RS06565	COG0557	exoribonuclease II activity
BBC0178_RS06575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BBC0178_RS06585	COG0746	molybdenum cofactor guanylyltransferase activity
BBC0178_RS06595	COG0625	glutathione transferase activity
BBC0178_RS06610	COG1573	uracil-dna glycosylase
BBC0178_RS06615	COG1522	sequence-specific DNA binding
BBC0178_RS06620	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BBC0178_RS06630	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BBC0178_RS06635	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BBC0178_RS06650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BBC0178_RS06655	COG0436	Aminotransferase
BBC0178_RS06670	COG0511	ligase activity, forming carbon-carbon bonds
BBC0178_RS06720	COG2999	glutathione oxidoreductase activity
BBC0178_RS06730	COG0538	isocitrate dehydrogenase activity
BBC0178_RS06745	COG2814	Major facilitator Superfamily
BBC0178_RS06760	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BBC0178_RS06820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBC0178_RS06825	COG0343	queuine tRNA-ribosyltransferase activity
BBC0178_RS06855	COG2095	MarC family integral membrane protein
BBC0178_RS06865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBC0178_RS06880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BBC0178_RS06880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BBC0178_RS06885	COG0347	Belongs to the P(II) protein family
BBC0178_RS06890	COG0174	glutamine synthetase
BBC0178_RS06910	COG1764	response to oxidative stress
BBC0178_RS06920	COG0546	phosphoglycolate phosphatase activity
BBC0178_RS06930	COG1132	(ABC) transporter
BBC0178_RS06940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BBC0178_RS06945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BBC0178_RS06950	COG2885	chlorophyll binding
BBC0178_RS06970	COG0203	ribosomal protein L17
BBC0178_RS06985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BBC0178_RS06990	COG0563	adenylate kinase activity
BBC0178_RS07000	COG0200	Binds to the 23S rRNA
BBC0178_RS07005	COG1841	ribosomal large subunit assembly
BBC0178_RS07010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BBC0178_RS07015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BBC0178_RS07020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BBC0178_RS07030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BBC0178_RS07035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BBC0178_RS07040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BBC0178_RS07045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BBC0178_RS07050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BBC0178_RS07060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BBC0178_RS07065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BBC0178_RS07075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BBC0178_RS07080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BBC0178_RS07090	COG0088	Forms part of the polypeptide exit tunnel
BBC0178_RS07095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BBC0178_RS07105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBC0178_RS07110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BBC0178_RS07115	COG0049	tRNA binding
BBC0178_RS07135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBC0178_RS07140	COG0765	amino acid transport
BBC0178_RS07145	COG0765	amino acid transport
BBC0178_RS07150	COG1126	abc transporter atp-binding protein
BBC0178_RS07185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BBC0178_RS07205	COG0625	glutathione transferase activity
BBC0178_RS07220	COG4993	Dehydrogenase
BBC0178_RS07235	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BBC0178_RS07245	COG0535	radical SAM domain protein
BBC0178_RS07255	COG2897	thiosulfate sulfurtransferase activity
BBC0178_RS07260	COG0513	Belongs to the DEAD box helicase family
BBC0178_RS07270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BBC0178_RS07285	COG3264	Mechanosensitive ion channel
BBC0178_RS07285	COG1196	nuclear chromosome segregation
BBC0178_RS07315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBC0178_RS07320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBC0178_RS07320	COG4651	solute:proton antiporter activity
BBC0178_RS07340	COG1253	flavin adenine dinucleotide binding
BBC0178_RS07350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBC0178_RS07355	COG0765	amino acid transport
BBC0178_RS07365	COG2801	Transposase and inactivated derivatives
BBC0178_RS07375	COG0384	phenazine biosynthesis protein PhzF
BBC0178_RS07400	COG3158	transport of potassium into the cell
BBC0178_RS07415	COG1301	dicarboxylic acid transport
BBC0178_RS07455	COG0028	Belongs to the TPP enzyme family
BBC0178_RS07465	COG1999	signal sequence binding
BBC0178_RS07475	COG0006	proline dipeptidase activity
BBC0178_RS07480	COG0697	spore germination
BBC0178_RS07490	COG0497	DNA recombination
BBC0178_RS07495	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBC0178_RS07510	COG0849	cell division
BBC0178_RS07520	COG1181	Belongs to the D-alanine--D-alanine ligase family
BBC0178_RS07525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBC0178_RS07530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBC0178_RS07535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BBC0178_RS07545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BBC0178_RS07550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBC0178_RS07560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BBC0178_RS07575	COG0275	rRNA processing
BBC0178_RS07580	COG1914	H( )-stimulated, divalent metal cation uptake system
BBC0178_RS07590	COG3023	N-Acetylmuramoyl-L-alanine amidase
BBC0178_RS07630	COG2226	methyltransferase
BBC0178_RS07640	COG1376	ErfK ybiS ycfS ynhG family protein
BBC0178_RS07645	COG4106	trans-aconitate 2-methyltransferase activity
BBC0178_RS07680	COG1335	isochorismatase
BBC0178_RS07685	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BBC0178_RS07690	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BBC0178_RS07725	COG2353	YceI-like domain
BBC0178_RS07770	COG4172	Belongs to the ABC transporter superfamily
BBC0178_RS07775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBC0178_RS07780	COG0601	transmembrane transport
BBC0178_RS07805	COG0477	Major facilitator Superfamily
BBC0178_RS07810	COG1454	alcohol dehydrogenase
BBC0178_RS07815	COG1012	belongs to the aldehyde dehydrogenase family
BBC0178_RS07830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BBC0178_RS07835	COG1061	Type III restriction enzyme res subunit
BBC0178_RS07840	COG1002	Type II restriction enzyme, methylase subunits
BBC0178_RS07850	COG2968	Membrane
BBC0178_RS07855	COG2983	Belongs to the UPF0260 family
BBC0178_RS07865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBC0178_RS07900	COG2321	neutral zinc metallopeptidase
BBC0178_RS07920	COG0672	)-iron permease
BBC0178_RS07940	COG1278	Cold shock
BBC0178_RS07955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBC0178_RS07960	COG1120	ATPase activity
BBC0178_RS07970	COG0436	Aminotransferase
BBC0178_RS07980	COG0583	DNA-binding transcription factor activity
BBC0178_RS07985	COG0492	ferredoxin-NADP+ reductase activity
BBC0178_RS07990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBC0178_RS07995	COG1522	sequence-specific DNA binding
BBC0178_RS08015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBC0178_RS08025	COG0556	nucleotide-excision repair
BBC0178_RS08030	COG1278	Cold shock
BBC0178_RS08040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBC0178_RS08050	COG0745	RESPONSE REGULATOR receiver
BBC0178_RS08055	COG2205	protein histidine kinase activity
BBC0178_RS08065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBC0178_RS08080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BBC0178_RS08100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BBC0178_RS08110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BBC0178_RS08115	COG0193	aminoacyl-tRNA hydrolase activity
BBC0178_RS08120	COG1388	LysM domain
BBC0178_RS08120	COG1376	ErfK ybiS ycfS ynhG family protein
BBC0178_RS08125	COG0012	GTP binding
BBC0178_RS08140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BBC0178_RS08140	COG2857	Cytochrome c1
BBC0178_RS08160	COG1132	(ABC) transporter
BBC0178_RS08170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBC0178_RS08180	COG0617	tRNA 3'-terminal CCA addition
BBC0178_RS08185	COG0494	nUDIX hydrolase
BBC0178_RS08190	COG0714	Associated with various cellular activities
BBC0178_RS08225	COG3047	cAMP biosynthetic process
BBC0178_RS08255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BBC0178_RS08260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBC0178_RS08260	COG0512	Glutamine amidotransferase of anthranilate synthase
BBC0178_RS08275	COG3448	diguanylate cyclase activity
BBC0178_RS08275	COG4175	Glycine betaine
BBC0178_RS08290	COG0482	sulfurtransferase activity
BBC0178_RS08325	COG2252	PERMEase
BBC0178_RS08335	COG0673	inositol 2-dehydrogenase activity
BBC0178_RS08350	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BBC0178_RS08370	COG0166	Belongs to the GPI family
BBC0178_RS08375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BBC0178_RS08385	COG5000	phosphorelay sensor kinase activity
BBC0178_RS08460	COG1027	Aspartate ammonia-lyase
BBC0178_RS08465	COG1126	abc transporter atp-binding protein
BBC0178_RS08470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BBC0178_RS08490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBC0178_RS08505	COG0656	L-ascorbic acid biosynthetic process
BBC0178_RS08545	COG2072	flavoprotein involved in K transport
BBC0178_RS08565	COG4176	ABC-type proline glycine betaine transport system permease component
BBC0178_RS08575	COG3257	ureidoglycine aminohydrolase activity
BBC0178_RS08600	COG0534	Mate efflux family protein
BBC0178_RS08605	COG0477	Major facilitator Superfamily
BBC0178_RS08615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BBC0178_RS08620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BBC0178_RS08665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBC0178_RS08665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBC0178_RS08670	COG1105	Belongs to the carbohydrate kinase PfkB family
BBC0178_RS08675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBC0178_RS08675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBC0178_RS08680	COG1609	Transcriptional regulator
BBC0178_RS08690	COG2084	Dehydrogenase
BBC0178_RS08695	COG1064	alcohol dehydrogenase
BBC0178_RS08710	COG4771	TonB-dependent receptor
BBC0178_RS08720	COG4607	ABC-type enterochelin transport system periplasmic component
BBC0178_RS08725	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBC0178_RS08730	COG4605	iron ion homeostasis
BBC0178_RS08735	COG4604	ABC transporter, ATP-binding protein
BBC0178_RS08740	COG2814	Major facilitator Superfamily
BBC0178_RS08745	COG0025	NhaP-type Na H and K H
BBC0178_RS08770	COG3620	sequence-specific DNA binding
BBC0178_RS08990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBC0178_RS09005	COG0792	nuclease activity
BBC0178_RS09010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BBC0178_RS09015	COG0427	acetyl-CoA hydrolase
BBC0178_RS09020	COG0284	orotidine-5'-phosphate decarboxylase activity
BBC0178_RS09030	COG0489	protein tyrosine kinase activity
BBC0178_RS09035	COG0400	carboxylic ester hydrolase activity
BBC0178_RS09055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BBC0178_RS09060	COG0594	ribonuclease P activity
BBC0178_RS09070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BBC0178_RS09080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BBC0178_RS09095	COG0837	glucose binding
BBC0178_RS09220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBC0178_RS09225	COG2274	protein secretion by the type I secretion system
BBC0178_RS09260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBC0178_RS09265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BBC0178_RS09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBC0178_RS09295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBC0178_RS09300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBC0178_RS09325	COG2362	D-Aminopeptidase
BBC0178_RS09335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBC0178_RS09345	COG0747	negative chemotaxis
BBC0178_RS09350	COG0747	negative chemotaxis
BBC0178_RS09355	COG4172	Belongs to the ABC transporter superfamily
BBC0178_RS09365	COG4770	biotin carboxylase activity
BBC0178_RS09370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BBC0178_RS09375	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BBC0178_RS09380	COG1802	Transcriptional regulator
BBC0178_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
BBC0178_RS09420	COG1132	(ABC) transporter
BBC0178_RS09420	COG2375	cellular response to nickel ion
BBC0178_RS09440	COG1620	l-lactate permease
BBC0178_RS09445	COG1304	FMN binding
BBC0178_RS09455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BBC0178_RS09455	COG1116	anion transmembrane transporter activity
BBC0178_RS09465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBC0178_RS09470	COG1733	regulation of RNA biosynthetic process
BBC0178_RS09475	COG2814	Major facilitator Superfamily
BBC0178_RS09480	COG0583	DNA-binding transcription factor activity
BBC0178_RS09485	COG4988	ABC transporter
BBC0178_RS09490	COG1132	(ABC) transporter
BBC0178_RS09495	COG1271	oxidase subunit
BBC0178_RS09500	COG1294	oxidase, subunit
BBC0178_RS09540	COG1470	cell adhesion involved in biofilm formation
BBC0178_RS09540	COG1388	LysM domain
BBC0178_RS09595	COG1121	(ABC) transporter
BBC0178_RS09600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBC0178_RS09605	COG0735	belongs to the Fur family
BBC0178_RS09640	COG0583	DNA-binding transcription factor activity
BBC0178_RS09650	COG0800	Aldolase
BBC0178_RS09670	COG2233	PERMEase
BBC0178_RS09675	COG0789	Transcriptional regulator
BBC0178_RS09680	COG1304	FMN binding
BBC0178_RS09690	COG1522	sequence-specific DNA binding
BBC0178_RS09700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBC0178_RS09710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BBC0178_RS09710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BBC0178_RS09715	COG0509	glycine decarboxylation via glycine cleavage system
BBC0178_RS09720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BBC0178_RS09725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BBC0178_RS09740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BBC0178_RS09745	COG2835	tetraacyldisaccharide 4'-kinase activity
BBC0178_RS09755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BBC0178_RS09765	COG1464	Belongs to the NlpA lipoprotein family
BBC0178_RS09770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBC0178_RS09775	COG2011	ABC-type metal ion transport system permease component
BBC0178_RS09790	COG2183	response to ionizing radiation
BBC0178_RS09795	COG1902	pentaerythritol trinitrate reductase activity
BBC0178_RS09805	COG0523	cobalamin synthesis protein
BBC0178_RS09815	COG1846	Transcriptional regulator
BBC0178_RS09820	COG1609	Transcriptional regulator
BBC0178_RS09825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BBC0178_RS09870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BBC0178_RS09910	COG0656	L-ascorbic acid biosynthetic process
BBC0178_RS09915	COG2258	MOSC domain
BBC0178_RS09940	COG0583	DNA-binding transcription factor activity
BBC0178_RS09945	COG1380	Effector of murein hydrolase LrgA
BBC0178_RS09950	COG1346	cytolysis
BBC0178_RS09955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BBC0178_RS09960	COG0129	dihydroxy-acid dehydratase activity
BBC0178_RS09965	COG0363	glucosamine-6-phosphate deaminase activity
BBC0178_RS09970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BBC0178_RS09980	COG0174	glutamine synthetase
BBC0178_RS09995	COG0167	dihydroorotate dehydrogenase activity
BBC0178_RS10010	COG1970	mechanosensitive ion channel activity
BBC0178_RS10030	COG1522	sequence-specific DNA binding
BBC0178_RS10055	COG0564	pseudouridine synthase activity
BBC0178_RS10060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBC0178_RS10075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BBC0178_RS10090	COG2271	Major facilitator Superfamily
BBC0178_RS10120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBC0178_RS10145	COG0831	urea catabolic process
BBC0178_RS10155	COG0832	Belongs to the urease beta subunit family
BBC0178_RS10160	COG0804	urea catabolic process
BBC0178_RS10165	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BBC0178_RS10170	COG0830	nickel cation binding
BBC0178_RS10175	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BBC0178_RS10195	COG3617	BRO family, N-terminal domain
BBC0178_RS10230	COG2315	Protein conserved in bacteria
BBC0178_RS10270	COG4942	peptidase
BBC0178_RS10285	COG0784	Response regulator, receiver
BBC0178_RS10310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BBC0178_RS10315	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BBC0178_RS10325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BBC0178_RS10375	COG1393	Belongs to the ArsC family
BBC0178_RS10395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BBC0178_RS10425	COG0756	dUTP diphosphatase activity
BBC0178_RS10430	COG2864	formate dehydrogenase
BBC0178_RS10435	COG0437	4 iron, 4 sulfur cluster binding
BBC0178_RS10450	COG0709	Synthesizes selenophosphate from selenide and ATP
BBC0178_RS10465	COG1921	L-seryl-tRNASec selenium transferase activity
BBC0178_RS10475	COG0848	biopolymer transport protein
BBC0178_RS10505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBC0178_RS10510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBC0178_RS10515	COG0037	tRNA processing
BBC0178_RS10525	COG2885	chlorophyll binding
BBC0178_RS10530	COG0823	Involved in the tonB-independent uptake of proteins
BBC0178_RS10555	COG0604	alcohol dehydrogenase
BBC0178_RS10575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BBC0178_RS10580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BBC0178_RS10585	COG0457	Tetratricopeptide repeat
BBC0178_RS10600	COG1692	metallophosphoesterase
BBC0178_RS10615	COG1132	(ABC) transporter
BBC0178_RS10625	COG0483	inositol monophosphate 1-phosphatase activity
BBC0178_RS10630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BBC0178_RS10660	COG0632	four-way junction helicase activity
BBC0178_RS10665	COG2255	four-way junction helicase activity
BBC0178_RS10670	COG0824	Thioesterase
BBC0178_RS10675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBC0178_RS10685	COG3588	fructose-bisphosphate aldolase
BBC0178_RS10690	COG0126	phosphoglycerate kinase activity
BBC0178_RS10715	COG0469	pyruvate kinase activity
BBC0178_RS10735	COG0488	(ABC) transporter
BBC0178_RS10760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBC0178_RS10765	COG1329	Transcriptional regulator
BBC0178_RS10770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BBC0178_RS10790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BBC0178_RS10880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BBC0178_RS10885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BBC0178_RS10895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BBC0178_RS10915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBC0178_RS10935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BBC0178_RS10940	COG1028	Short-chain dehydrogenase reductase Sdr
BBC0178_RS10945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBC0178_RS10950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBC0178_RS10955	COG0280	phosphate acetyltransferase
BBC0178_RS10965	COG3920	Histidine kinase
BBC0178_RS10965	COG2202	Pas domain
BBC0178_RS10975	COG2884	Cell division ATP-binding protein ftsE
BBC0178_RS10990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBC0178_RS11000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBC0178_RS11025	COG0004	ammonium transporteR
BBC0178_RS11030	COG0347	Belongs to the P(II) protein family
BBC0178_RS11035	COG1946	Acyl-CoA thioesterase
BBC0178_RS11040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBC0178_RS11080	COG0335	large ribosomal subunit rRNA binding
BBC0178_RS11085	COG0336	Belongs to the RNA methyltransferase TrmD family
BBC0178_RS11090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BBC0178_RS11145	COG2271	Major facilitator Superfamily
BBC0178_RS11175	COG0697	spore germination
BBC0178_RS11200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BBC0178_RS11200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBC0178_RS11205	COG0501	Belongs to the peptidase M48B family
BBC0178_RS11210	COG5508	conserved small protein
BBC0178_RS11215	COG0228	four-way junction DNA binding
BBC0178_RS11225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BBC0178_RS11235	COG0288	reversible hydration of carbon dioxide
BBC0178_RS11250	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BBC0178_RS11255	COG0519	Catalyzes the synthesis of GMP from XMP
BBC0178_RS11255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BBC0178_RS11280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BBC0178_RS11300	COG2264	protein methyltransferase activity
BBC0178_RS11305	COG3034	peptidoglycan biosynthetic process
BBC0178_RS11320	COG0523	cobalamin synthesis protein
BBC0178_RS11325	COG1686	Belongs to the peptidase S11 family
BBC0178_RS11330	COG0589	response to stress
BBC0178_RS11335	COG1268	BioY protein
BBC0178_RS11345	COG1122	ATPase activity
BBC0178_RS11375	COG0351	phosphomethylpyrimidine kinase
BBC0178_RS11390	COG0471	metal ion transport
BBC0178_RS11460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BBC0178_RS11470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BBC0178_RS11475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BBC0178_RS11485	COG0287	Prephenate dehydrogenase
BBC0178_RS11495	COG2212	antiporter activity
BBC0178_RS11500	COG1863	multisubunit Na H antiporter MnhE subunit
BBC0178_RS11505	COG0651	ATP synthesis coupled electron transport
BBC0178_RS11510	COG1006	Multisubunit Na H antiporter MnhC subunit
BBC0178_RS11515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BBC0178_RS11515	COG2111	Na H antiporter
BBC0178_RS11525	COG0019	diaminopimelate decarboxylase activity
BBC0178_RS11545	COG1280	lysine exporter protein (LysE YggA)
BBC0178_RS11555	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBC0178_RS11560	COG0567	Dehydrogenase, E1 component
BBC0178_RS11565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BBC0178_RS11570	COG0045	succinate-CoA ligase (ADP-forming) activity
BBC0178_RS11575	COG0039	L-malate dehydrogenase activity
BBC0178_RS11580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BBC0178_RS11590	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBC0178_RS11595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBC0178_RS11600	COG0552	protein localization to endoplasmic reticulum
BBC0178_RS11610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBC0178_RS11630	COG0357	Ribosomal RNA small subunit methyltransferase G
BBC0178_RS11635	COG0445	tRNA wobble uridine modification
BBC0178_RS11640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BBC0178_RS11645	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BBC0178_RS11650	COG1981	membrane
BBC0178_RS11655	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III