locus-tag	class	description
AL467_RS00010	COG0729	surface antigen
AL467_RS00025	COG2226	methyltransferase
AL467_RS00030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL467_RS00035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL467_RS00050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL467_RS00055	COG0285	dihydrofolate synthase activity
AL467_RS00065	COG2205	protein histidine kinase activity
AL467_RS00070	COG3178	'Phosphotransferase
AL467_RS00090	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL467_RS00100	COG0137	argininosuccinate synthase activity
AL467_RS00110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL467_RS00120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL467_RS00130	COG1137	ATPase activity
AL467_RS00145	COG0776	regulation of translation
AL467_RS00155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL467_RS00155	COG0116	Belongs to the methyltransferase superfamily
AL467_RS00160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL467_RS00165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL467_RS00170	COG0670	Belongs to the BI1 family
AL467_RS00180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL467_RS00180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL467_RS00185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL467_RS00190	COG0237	dephospho-CoA kinase activity
AL467_RS00195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL467_RS00200	COG0424	maF-like protein
AL467_RS00205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL467_RS00210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL467_RS00215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL467_RS00220	COG0445	tRNA wobble uridine modification
AL467_RS00225	COG0357	Ribosomal RNA small subunit methyltransferase G
AL467_RS00245	COG2917	probably involved in intracellular septation
AL467_RS00250	COG0552	protein localization to endoplasmic reticulum
AL467_RS00255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL467_RS00260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL467_RS00270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL467_RS00275	COG0039	L-malate dehydrogenase activity
AL467_RS00280	COG0045	succinate-CoA ligase (ADP-forming) activity
AL467_RS00285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL467_RS00290	COG0567	Dehydrogenase, E1 component
AL467_RS00295	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL467_RS00310	COG0019	diaminopimelate decarboxylase activity
AL467_RS00315	COG2111	Na H antiporter
AL467_RS00315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL467_RS00320	COG1006	Multisubunit Na H antiporter MnhC subunit
AL467_RS00325	COG0651	ATP synthesis coupled electron transport
AL467_RS00330	COG1863	multisubunit Na H antiporter MnhE subunit
AL467_RS00335	COG2212	antiporter activity
AL467_RS00340	COG1320	monovalent cation:proton antiporter activity
AL467_RS00350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL467_RS00355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL467_RS00365	COG0825	malonyl-CoA metabolic process
AL467_RS00370	COG3034	peptidoglycan biosynthetic process
AL467_RS00375	COG1686	Belongs to the peptidase S11 family
AL467_RS00405	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AL467_RS00410	COG1466	dna polymerase III delta subunit
AL467_RS00420	COG1671	Belongs to the UPF0178 family
AL467_RS00425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL467_RS00430	COG0165	Argininosuccinate lyase
AL467_RS00440	COG0019	diaminopimelate decarboxylase activity
AL467_RS00455	COG0745	RESPONSE REGULATOR receiver
AL467_RS00470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL467_RS00485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL467_RS00485	COG0519	Catalyzes the synthesis of GMP from XMP
AL467_RS00490	COG2902	Dehydrogenase
AL467_RS00495	COG0288	reversible hydration of carbon dioxide
AL467_RS00500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL467_RS00505	COG0228	four-way junction DNA binding
AL467_RS00515	COG0501	Belongs to the peptidase M48B family
AL467_RS00530	COG0138	bifunctional purine biosynthesis protein purh
AL467_RS00545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL467_RS00550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL467_RS00575	COG4974	Belongs to the 'phage' integrase family
AL467_RS00585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL467_RS00590	COG0336	Belongs to the RNA methyltransferase TrmD family
AL467_RS00595	COG0335	large ribosomal subunit rRNA binding
AL467_RS00605	COG2009	succinate dehydrogenase
AL467_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL467_RS00645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL467_RS00650	COG1136	(ABC) transporter
AL467_RS00650	COG0577	efflux transmembrane transporter activity
AL467_RS00665	COG2884	Cell division ATP-binding protein ftsE
AL467_RS00670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL467_RS00680	COG0495	leucyl-tRNA aminoacylation
AL467_RS00690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL467_RS00710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL467_RS00715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL467_RS00720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL467_RS00725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL467_RS00730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL467_RS00740	COG1566	PFAM secretion protein HlyD family protein
AL467_RS00745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL467_RS00760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL467_RS00770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL467_RS00780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL467_RS00785	COG4783	chaperone-mediated protein folding
AL467_RS00800	COG0488	(ABC) transporter
AL467_RS00805	COG3750	Belongs to the UPF0335 family
AL467_RS00835	COG0126	phosphoglycerate kinase activity
AL467_RS00840	COG3588	fructose-bisphosphate aldolase
AL467_RS00850	COG0823	Involved in the tonB-independent uptake of proteins
AL467_RS00875	COG0824	Thioesterase
AL467_RS00880	COG2255	four-way junction helicase activity
AL467_RS00885	COG0632	four-way junction helicase activity
AL467_RS00890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL467_RS00915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL467_RS00920	COG0483	inositol monophosphate 1-phosphatase activity
AL467_RS00925	COG1132	(ABC) transporter
AL467_RS00930	COG0254	rRNA binding
AL467_RS00940	COG0217	transcriptional regulatory protein
AL467_RS00950	COG2885	chlorophyll binding
AL467_RS00965	COG0037	tRNA processing
AL467_RS00965	COG0037	tRNA processing
AL467_RS00970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL467_RS00975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL467_RS00990	COG0848	biopolymer transport protein
AL467_RS01000	COG0756	dUTP diphosphatase activity
AL467_RS01020	COG1238	metal cluster binding
AL467_RS01090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL467_RS01095	COG1692	metallophosphoesterase
AL467_RS01110	COG0457	Tetratricopeptide repeat
AL467_RS01115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL467_RS01130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL467_RS01135	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL467_RS01150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL467_RS01155	COG0424	maF-like protein
AL467_RS01160	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL467_RS01165	COG0542	response to heat
AL467_RS01315	COG0784	Response regulator, receiver
AL467_RS01325	COG3920	Histidine kinase
AL467_RS01395	COG4680	protein conserved in bacteria
AL467_RS01405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL467_RS01435	COG3657	addiction module killer protein
AL467_RS01470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL467_RS01480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL467_RS01485	COG0564	pseudouridine synthase activity
AL467_RS01500	COG1970	mechanosensitive ion channel activity
AL467_RS01505	COG0167	dihydroorotate dehydrogenase activity
AL467_RS01515	COG0174	glutamine synthetase
AL467_RS01520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL467_RS01525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL467_RS01545	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL467_RS01560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL467_RS01565	COG0166	Belongs to the GPI family
AL467_RS01575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL467_RS01580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL467_RS01605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL467_RS01610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL467_RS01615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL467_RS01620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL467_RS01625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL467_RS01630	COG0799	negative regulation of ribosome biogenesis
AL467_RS01635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL467_RS01645	COG0793	Belongs to the peptidase S41A family
AL467_RS01650	COG0494	nUDIX hydrolase
AL467_RS01655	COG5342	invasion associated locus B
AL467_RS01665	COG1872	DUF167
AL467_RS01670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL467_RS01675	COG1217	gtp-binding protein TYPA
AL467_RS01680	COG2239	Acts as a magnesium transporter
AL467_RS01685	COG0339	signal peptide processing
AL467_RS01690	COG2951	lytic endotransglycosylase activity
AL467_RS01695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL467_RS01700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL467_RS01700	COG0517	IMP dehydrogenase activity
AL467_RS01730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL467_RS01730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL467_RS01735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL467_RS01735	COG0519	Catalyzes the synthesis of GMP from XMP
AL467_RS01745	COG3842	ATPase activity
AL467_RS01750	COG0395	ABC-type sugar transport system, permease component
AL467_RS01755	COG1175	transmembrane transport
AL467_RS01765	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL467_RS01775	COG1121	(ABC) transporter
AL467_RS01785	COG1780	Probably involved in ribonucleotide reductase function
AL467_RS01790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL467_RS01800	COG2890	protein-(glutamine-N5) methyltransferase activity
AL467_RS01805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL467_RS01815	COG0653	protein targeting
AL467_RS01820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL467_RS01825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AL467_RS01830	COG0494	nUDIX hydrolase
AL467_RS01835	COG1823	symporter activity
AL467_RS01840	COG2226	methyltransferase
AL467_RS01845	COG1040	competence protein
AL467_RS01850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL467_RS01855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL467_RS01860	COG0527	aspartate kinase activity
AL467_RS01865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL467_RS01880	COG1160	GTP binding
AL467_RS01890	COG0356	it plays a direct role in the translocation of protons across the membrane
AL467_RS01895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL467_RS01900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL467_RS01905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL467_RS01910	COG0751	glycine-tRNA ligase activity
AL467_RS01925	COG0142	geranyltranstransferase activity
AL467_RS01945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL467_RS01950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL467_RS01960	COG0277	FAD linked oxidase domain protein
AL467_RS01980	COG0259	pyridoxamine-phosphate oxidase activity
AL467_RS01985	COG0484	heat shock protein binding
AL467_RS01990	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL467_RS01995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL467_RS02000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL467_RS02000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL467_RS02005	COG1722	exodeoxyribonuclease VII activity
AL467_RS02010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL467_RS02015	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AL467_RS02020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL467_RS02025	COG0312	modulator of DNA gyrase
AL467_RS02035	COG0109	protoheme IX farnesyltransferase activity
AL467_RS02040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL467_RS02045	COG0328	RNA-DNA hybrid ribonuclease activity
AL467_RS02060	COG5001	Diguanylate cyclase
AL467_RS02060	COG1716	ATPase activity
AL467_RS02065	COG0612	Peptidase, M16
AL467_RS02070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL467_RS02075	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AL467_RS02080	COG1194	a g-specific adenine glycosylase
AL467_RS02095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL467_RS02095	COG0574	Belongs to the PEP-utilizing enzyme family
AL467_RS02105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL467_RS02120	COG2166	iron-sulfur cluster assembly
AL467_RS02155	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL467_RS02160	COG1138	Cytochrome C-type biogenesis protein
AL467_RS02165	COG3088	subunit of a heme lyase
AL467_RS02170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL467_RS02175	COG0745	RESPONSE REGULATOR receiver
AL467_RS02185	COG2202	Pas domain
AL467_RS02185	COG2205	protein histidine kinase activity
AL467_RS02190	COG0308	aminopeptidase N
AL467_RS02200	COG0351	phosphomethylpyrimidine kinase
AL467_RS02210	COG2022	thiamine diphosphate biosynthetic process
AL467_RS02225	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL467_RS02265	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL467_RS02275	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL467_RS02280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL467_RS02285	COG4558	Periplasmic binding protein
AL467_RS02290	COG3720	iron ion transport
AL467_RS02295	COG4771	TonB-dependent receptor
AL467_RS02310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL467_RS02315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL467_RS02320	COG1573	uracil-dna glycosylase
AL467_RS02325	COG1758	RNA polymerase activity
AL467_RS02335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL467_RS02345	COG0736	holo-[acyl-carrier-protein] synthase activity
AL467_RS02355	COG0571	ribonuclease III activity
AL467_RS02365	COG1381	Involved in DNA repair and RecF pathway recombination
AL467_RS02370	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL467_RS02375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL467_RS02390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AL467_RS02395	COG0215	cysteine-tRNA ligase activity
AL467_RS02400	COG5265	(ABC) transporter
AL467_RS02405	COG0688	phosphatidylethanolamine metabolic process
AL467_RS02410	COG1183	phosphatidylcholine synthase activity
AL467_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
AL467_RS02420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL467_RS02440	COG0305	Participates in initiation and elongation during chromosome replication
AL467_RS02445	COG0359	binds to the 23S rRNA
AL467_RS02455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL467_RS02460	COG0360	Binds together with S18 to 16S ribosomal RNA
AL467_RS02465	COG0671	phosphoesterase, PA-phosphatase related
AL467_RS02470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AL467_RS02480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL467_RS02485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL467_RS02490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL467_RS02495	COG0194	GDP metabolic process
AL467_RS02500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL467_RS02505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL467_RS02510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL467_RS02555	COG0105	UTP biosynthetic process
AL467_RS02560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL467_RS02565	COG0322	excinuclease ABC activity
AL467_RS02570	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL467_RS02580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL467_RS02585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL467_RS02590	COG0739	heme binding
AL467_RS02590	COG1388	LysM domain
AL467_RS02595	COG1862	Preprotein translocase
AL467_RS02605	COG1562	ergosterol biosynthetic process
AL467_RS02615	COG0149	triose-phosphate isomerase activity
AL467_RS02625	COG0504	CTP synthase activity
AL467_RS02630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL467_RS02635	COG0148	phosphopyruvate hydratase activity
AL467_RS02645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL467_RS02650	COG0022	dehydrogenase e1 component
AL467_RS02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL467_RS02655	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL467_RS02660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL467_RS02665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL467_RS02670	COG2867	negative regulation of translational initiation
AL467_RS02675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL467_RS02675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL467_RS02680	COG5000	phosphorelay sensor kinase activity
AL467_RS02685	COG2204	response regulator
AL467_RS02690	COG0569	domain protein
AL467_RS02700	COG0740	serine-type endopeptidase activity
AL467_RS02705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL467_RS02720	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AL467_RS02730	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL467_RS02735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL467_RS02745	COG4765	Protein conserved in bacteria
AL467_RS02760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL467_RS02775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL467_RS02785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL467_RS02795	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL467_RS02800	COG0081	regulation of translation
AL467_RS02805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL467_RS02810	COG0222	ribosome binding
AL467_RS02815	COG0085	RNA polymerase activity
AL467_RS02820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL467_RS02835	COG1686	Belongs to the peptidase S11 family
AL467_RS02850	COG0537	adenosine 5'-monophosphoramidase activity
AL467_RS02865	COG0052	Belongs to the universal ribosomal protein uS2 family
AL467_RS02870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL467_RS02875	COG0528	UMP kinase activity
AL467_RS02880	COG0233	cytoplasmic translational termination
AL467_RS02900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL467_RS02905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL467_RS02910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL467_RS02920	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL467_RS02925	COG1126	abc transporter atp-binding protein
AL467_RS02935	COG4215	(ABC) transporter
AL467_RS02940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL467_RS02945	COG0372	Belongs to the citrate synthase family
AL467_RS02950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL467_RS02955	COG2333	competence protein COMEC
AL467_RS02955	COG0658	competence protein
AL467_RS02960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL467_RS02975	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AL467_RS02985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL467_RS02985	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AL467_RS02990	COG0513	Belongs to the DEAD box helicase family
AL467_RS03015	COG0071	Belongs to the small heat shock protein (HSP20) family
AL467_RS03025	COG0316	Belongs to the HesB IscA family
AL467_RS03040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL467_RS03050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL467_RS03055	COG0281	malic enzyme
AL467_RS03055	COG0280	phosphate acetyltransferase
AL467_RS03065	COG1923	regulation of RNA biosynthetic process
AL467_RS03070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL467_RS03080	COG1612	heme a metabolic process
AL467_RS03090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL467_RS03095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL467_RS03100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL467_RS03100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL467_RS03110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL467_RS03115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL467_RS03130	COG0416	fatty acid biosynthetic process
AL467_RS03135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL467_RS03140	COG0776	regulation of translation
AL467_RS03150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL467_RS03155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL467_RS03165	COG0302	gtp cyclohydrolase
AL467_RS03200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL467_RS03215	COG0525	valine-tRNA ligase activity
AL467_RS03220	COG1126	abc transporter atp-binding protein
AL467_RS03225	COG0765	amino acid transport
AL467_RS03230	COG0765	amino acid transport
AL467_RS03260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL467_RS03280	COG0089	rRNA binding
AL467_RS03290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL467_RS03295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL467_RS03300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL467_RS03305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL467_RS03310	COG0255	Belongs to the universal ribosomal protein uL29 family
AL467_RS03315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL467_RS03320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL467_RS03325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL467_RS03330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL467_RS03360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL467_RS03375	COG0525	valine-tRNA ligase activity
AL467_RS03380	COG1126	abc transporter atp-binding protein
AL467_RS03385	COG0765	amino acid transport
AL467_RS03390	COG0765	amino acid transport
AL467_RS03405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL467_RS03410	COG0049	tRNA binding
AL467_RS03415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL467_RS03420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL467_RS03430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL467_RS03435	COG0088	Forms part of the polypeptide exit tunnel
AL467_RS03440	COG0089	rRNA binding
AL467_RS03445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL467_RS03450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL467_RS03455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL467_RS03460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL467_RS03465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL467_RS03470	COG0255	Belongs to the universal ribosomal protein uL29 family
AL467_RS03475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL467_RS03480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL467_RS03485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL467_RS03490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL467_RS03495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL467_RS03500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL467_RS03505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL467_RS03510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL467_RS03515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL467_RS03520	COG1841	ribosomal large subunit assembly
AL467_RS03525	COG0200	Binds to the 23S rRNA
AL467_RS03535	COG0563	adenylate kinase activity
AL467_RS03540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL467_RS03545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL467_RS03550	COG0202	RNA polymerase activity
AL467_RS03555	COG0203	ribosomal protein L17
AL467_RS03560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL467_RS03565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL467_RS03575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL467_RS03580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL467_RS03585	COG1132	(ABC) transporter
AL467_RS03605	COG0174	glutamine synthetase
AL467_RS03620	COG0629	single-stranded DNA binding
AL467_RS03625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL467_RS03630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL467_RS03645	COG0343	queuine tRNA-ribosyltransferase activity
AL467_RS03655	COG0538	isocitrate dehydrogenase activity
AL467_RS03670	COG1494	fructose-1,6-bisphosphatase
AL467_RS03675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL467_RS03685	COG0018	arginyl-trna synthetase
AL467_RS03690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL467_RS03695	COG0316	Belongs to the HesB IscA family
AL467_RS03705	COG0785	Cytochrome C biogenesis protein
AL467_RS03710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL467_RS03715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL467_RS03720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL467_RS03740	COG0439	Biotin carboxylase
AL467_RS03745	COG0511	ligase activity, forming carbon-carbon bonds
AL467_RS03755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL467_RS03760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL467_RS03765	COG0628	permease
AL467_RS03825	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL467_RS03830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL467_RS03835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL467_RS03840	COG0649	NAD binding
AL467_RS03845	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AL467_RS03850	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AL467_RS03860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AL467_RS03865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL467_RS03875	COG0713	ATP synthesis coupled electron transport
AL467_RS03890	COG1007	ATP synthesis coupled electron transport
AL467_RS03905	COG0442	prolyl-tRNA aminoacylation
AL467_RS03915	COG1136	(ABC) transporter
AL467_RS03920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL467_RS03925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL467_RS03930	COG4166	transmembrane transport
AL467_RS03950	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL467_RS03955	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL467_RS03965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL467_RS03970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL467_RS03975	COG2945	thiolester hydrolase activity
AL467_RS03980	COG1104	cysteine desulfurase activity
AL467_RS03985	COG0719	Fe-S assembly protein
AL467_RS03990	COG0396	ATPase activity
AL467_RS03995	COG0719	Fe-S assembly protein
AL467_RS04000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL467_RS04015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL467_RS04020	COG1183	phosphatidylcholine synthase activity
AL467_RS04030	COG0084	hydrolase, TatD family'
AL467_RS04035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL467_RS04045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL467_RS04060	COG0037	tRNA processing
AL467_RS04065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL467_RS04070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL467_RS04080	COG0024	Methionine aminopeptidase
AL467_RS04085	COG2003	Belongs to the UPF0758 family
AL467_RS04095	COG2267	carboxylic ester hydrolase activity
AL467_RS04105	COG1278	Cold shock
AL467_RS04110	COG0154	amidase activity
AL467_RS04115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL467_RS04120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL467_RS04130	COG0540	Belongs to the ATCase OTCase family
AL467_RS04140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL467_RS04145	COG0758	DNA mediated transformation
AL467_RS04155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL467_RS04160	COG0557	exoribonuclease II activity
AL467_RS04175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL467_RS04190	COG1522	sequence-specific DNA binding
AL467_RS04200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL467_RS04215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL467_RS04225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL467_RS04235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL467_RS04240	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL467_RS04245	COG0047	phosphoribosylformylglycinamidine synthase activity
AL467_RS04250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL467_RS04265	COG2814	Major facilitator Superfamily
AL467_RS04270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL467_RS04275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL467_RS04280	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL467_RS04290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL467_RS04305	COG0513	Belongs to the DEAD box helicase family
AL467_RS04330	COG0392	lysyltransferase activity
AL467_RS04330	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AL467_RS04335	COG1253	flavin adenine dinucleotide binding
AL467_RS04390	COG0321	lipoyl(octanoyl) transferase activity
AL467_RS04395	COG0187	DNA topoisomerase II activity
AL467_RS04405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL467_RS04410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL467_RS04415	COG0784	Response regulator, receiver
AL467_RS04420	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL467_RS04445	COG1113	amino acid transport
AL467_RS04450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL467_RS04460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL467_RS04475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL467_RS04495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL467_RS04500	COG0477	Major facilitator Superfamily
AL467_RS04535	COG1999	signal sequence binding
AL467_RS04545	COG0006	proline dipeptidase activity
AL467_RS04550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL467_RS04560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL467_RS04575	COG0849	cell division
AL467_RS04585	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL467_RS04590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL467_RS04595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL467_RS04600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL467_RS04610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL467_RS04615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL467_RS04625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL467_RS04640	COG0275	rRNA processing
AL467_RS04660	COG1335	isochorismatase
AL467_RS04685	COG2968	Membrane
AL467_RS04690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL467_RS04695	COG0358	DNA primase activity
AL467_RS04700	COG0668	transmembrane transport
AL467_RS04705	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL467_RS04715	COG3161	chorismate lyase activity
AL467_RS04720	COG0505	Belongs to the CarA family
AL467_RS04740	COG1278	Cold shock
AL467_RS04745	COG0436	Aminotransferase
AL467_RS04750	COG0583	DNA-binding transcription factor activity
AL467_RS04755	COG0492	ferredoxin-NADP+ reductase activity
AL467_RS04760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL467_RS04770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL467_RS04780	COG0556	nucleotide-excision repair
AL467_RS04790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL467_RS04795	COG0745	RESPONSE REGULATOR receiver
AL467_RS04800	COG2205	protein histidine kinase activity
AL467_RS04815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL467_RS04835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL467_RS04840	COG0193	aminoacyl-tRNA hydrolase activity
AL467_RS04845	COG1376	ErfK ybiS ycfS ynhG family protein
AL467_RS04850	COG0012	GTP binding
AL467_RS04860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL467_RS04865	COG0617	tRNA 3'-terminal CCA addition
AL467_RS04870	COG0714	Associated with various cellular activities
AL467_RS04900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL467_RS04910	COG0482	sulfurtransferase activity
AL467_RS04960	COG4608	Belongs to the ABC transporter superfamily
AL467_RS04965	COG0444	Belongs to the ABC transporter superfamily
AL467_RS04970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL467_RS04975	COG0601	transmembrane transport
AL467_RS04980	COG0747	negative chemotaxis
AL467_RS04990	COG0519	Catalyzes the synthesis of GMP from XMP
AL467_RS04995	COG1570	exodeoxyribonuclease VII activity
AL467_RS05010	COG2086	electron transfer activity
AL467_RS05015	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AL467_RS05035	COG0792	nuclease activity
AL467_RS05040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL467_RS05050	COG0489	protein tyrosine kinase activity
AL467_RS05055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL467_RS05060	COG0594	ribonuclease P activity
AL467_RS05070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL467_RS05080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL467_RS05085	COG0588	phosphoglycerate mutase activity
AL467_RS05110	COG1598	PFAM Uncharacterised protein family UPF0150
AL467_RS05160	COG3561	AntA/AntB antirepressor
AL467_RS05260	COG1054	Belongs to the UPF0176 family
AL467_RS05275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL467_RS05275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL467_RS05280	COG0509	glycine decarboxylation via glycine cleavage system
AL467_RS05285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL467_RS05290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL467_RS05295	COG2835	tetraacyldisaccharide 4'-kinase activity
AL467_RS05305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL467_RS05315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL467_RS05320	COG2011	ABC-type metal ion transport system permease component
AL467_RS05355	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL467_RS05360	COG4605	iron ion homeostasis
AL467_RS05365	COG4604	ABC transporter, ATP-binding protein
AL467_RS05380	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL467_RS05400	COG1256	bacterial-type flagellum assembly
AL467_RS05475	COG1338	Plays a role in the flagellum-specific transport system
AL467_RS05485	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL467_RS05495	COG1706	bacterial-type flagellum-dependent cell motility
AL467_RS05500	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AL467_RS05505	COG4786	Flagellar basal body rod
AL467_RS05510	COG1677	Flagellar hook-basal body complex protein FliE
AL467_RS05515	COG1558	bacterial-type flagellum-dependent cell motility
AL467_RS05520	COG1815	bacterial-type flagellum-dependent cell motility
AL467_RS05525	COG1157	protein secretion by the type III secretion system
AL467_RS05530	COG4786	Flagellar basal body rod
AL467_RS05540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL467_RS05555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL467_RS05560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL467_RS05565	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL467_RS05595	COG1684	flagellar biosynthetic protein fliR
AL467_RS05600	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL467_RS05610	COG0196	riboflavin kinase activity
AL467_RS05620	COG0728	peptidoglycan biosynthetic process
AL467_RS05625	COG0180	Tryptophanyl-tRNA synthetase
AL467_RS05635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL467_RS05645	COG0459	protein refolding
AL467_RS05650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL467_RS05660	COG0033	Phosphoglucomutase
AL467_RS05670	COG0124	histidyl-tRNA synthetase
AL467_RS05725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL467_RS05730	COG1113	amino acid transport
AL467_RS05735	COG1268	BioY protein
AL467_RS05740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AL467_RS05745	COG1122	ATPase activity
AL467_RS05750	COG1113	amino acid transport
AL467_RS05765	COG0717	Belongs to the dCTP deaminase family
AL467_RS05770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL467_RS05780	COG1663	tetraacyldisaccharide 4'-kinase activity
AL467_RS05785	COG1519	Transferase
AL467_RS05805	COG0312	modulator of DNA gyrase
AL467_RS05810	COG0742	ribosomal rna small subunit methyltransferase
AL467_RS05820	COG0590	tRNA wobble adenosine to inosine editing
AL467_RS05825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL467_RS05830	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AL467_RS05835	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AL467_RS05865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL467_RS05870	COG2309	aminopeptidase activity
AL467_RS05880	COG0704	Plays a role in the regulation of phosphate uptake
AL467_RS05885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL467_RS05890	COG0581	inorganic phosphate transmembrane transporter activity
AL467_RS05895	COG0573	inorganic phosphate transmembrane transporter activity
AL467_RS05905	COG0189	ligase activity
AL467_RS05910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL467_RS05930	COG3474	cytochrome
AL467_RS05935	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL467_RS05945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL467_RS05950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL467_RS05955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL467_RS05960	COG1214	PFAM Peptidase M22, glycoprotease
AL467_RS05970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL467_RS05975	COG1702	phosphate starvation-inducible protein PhoH
AL467_RS05980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL467_RS05990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL467_RS05995	COG1396	sequence-specific DNA binding
AL467_RS06000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL467_RS06005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL467_RS06010	COG0779	Required for maturation of 30S ribosomal subunits
AL467_RS06015	COG0195	Participates in both transcription termination and antitermination
AL467_RS06015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL467_RS06025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL467_RS06030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL467_RS06035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL467_RS06040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL467_RS06045	COG1185	polyribonucleotide nucleotidyltransferase activity
AL467_RS06050	COG2813	Specifically methylates the guanine in position
AL467_RS06055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL467_RS06060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL467_RS06065	COG0252	asparaginase activity
AL467_RS06070	COG1072	(Pantothenic acid kinase))
AL467_RS06075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL467_RS06095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL467_RS06105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL467_RS06110	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL467_RS06120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL467_RS06130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL467_RS06145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL467_RS06150	COG0268	Binds directly to 16S ribosomal RNA
AL467_RS06155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL467_RS06160	COG4133	protoheme IX ABC transporter activity
AL467_RS06165	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL467_RS06170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL467_RS06180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL467_RS06190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL467_RS06215	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL467_RS06220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL467_RS06230	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL467_RS06245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL467_RS06250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL467_RS06255	COG0539	negative regulation of cytoplasmic translation
AL467_RS06260	COG3459	Glycosyltransferase 36 associated
AL467_RS06265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL467_RS06270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL467_RS06275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL467_RS06280	COG1121	(ABC) transporter
AL467_RS06290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL467_RS06290	COG0072	phenylalanine-tRNA ligase activity
AL467_RS06295	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL467_RS06300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL467_RS06305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL467_RS06325	COG0242	peptide deformylase activity
AL467_RS06330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL467_RS06335	COG0101	tRNA pseudouridine synthase activity
AL467_RS06345	COG2171	N-acyltransferase activity
AL467_RS06350	COG0481	GTPase activity
AL467_RS06360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL467_RS06365	COG0484	heat shock protein binding
AL467_RS06370	COG0443	Heat shock 70 kDa protein
AL467_RS06380	COG0745	RESPONSE REGULATOR receiver
AL467_RS06385	COG2205	protein histidine kinase activity
AL467_RS06390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL467_RS06400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL467_RS06405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL467_RS06410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL467_RS06425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AL467_RS06430	COG1132	(ABC) transporter