locus-tag	class	description
BARCL_RS00015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BARCL_RS00020	COG0424	maF-like protein
BARCL_RS00030	COG0237	dephospho-CoA kinase activity
BARCL_RS00035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BARCL_RS00040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BARCL_RS00040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BARCL_RS00050	COG0670	Belongs to the BI1 family
BARCL_RS00055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BARCL_RS00060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BARCL_RS00065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BARCL_RS00065	COG0116	Belongs to the methyltransferase superfamily
BARCL_RS00075	COG0776	regulation of translation
BARCL_RS00090	COG1137	ATPase activity
BARCL_RS00105	COG0137	argininosuccinate synthase activity
BARCL_RS00115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BARCL_RS00145	COG0802	atpase or kinase
BARCL_RS00150	COG2205	protein histidine kinase activity
BARCL_RS00155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BARCL_RS00165	COG0285	dihydrofolate synthase activity
BARCL_RS00170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BARCL_RS00180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BARCL_RS00185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BARCL_RS00190	COG2226	methyltransferase
BARCL_RS00220	COG1132	(ABC) transporter
BARCL_RS00225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BARCL_RS00240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BARCL_RS00245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BARCL_RS00250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BARCL_RS00255	COG1420	regulation of RNA biosynthetic process
BARCL_RS00260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BARCL_RS00265	COG2205	protein histidine kinase activity
BARCL_RS00270	COG0745	RESPONSE REGULATOR receiver
BARCL_RS00280	COG0443	Heat shock 70 kDa protein
BARCL_RS00285	COG0484	heat shock protein binding
BARCL_RS00290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BARCL_RS00300	COG2184	nucleotidyltransferase activity
BARCL_RS00305	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BARCL_RS00310	COG2948	multi-organism process
BARCL_RS00315	COG3504	Conjugal transfer protein
BARCL_RS00320	COG3736	Type IV secretory pathway, component VirB8
BARCL_RS00335	COG3704	protein secretion by the type IV secretion system
BARCL_RS00345	COG3451	type IV secretory pathway VirB4
BARCL_RS00350	COG3702	type iv secretory pathway
BARCL_RS00355	COG3838	Conjugal transfer protein Trbc
BARCL_RS00360	COG2171	N-acyltransferase activity
BARCL_RS00365	COG0481	GTPase activity
BARCL_RS00370	COG0101	tRNA pseudouridine synthase activity
BARCL_RS00375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BARCL_RS00380	COG0242	peptide deformylase activity
BARCL_RS00405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BARCL_RS00410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BARCL_RS00415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BARCL_RS00420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BARCL_RS00420	COG0072	phenylalanine-tRNA ligase activity
BARCL_RS00430	COG1121	(ABC) transporter
BARCL_RS00435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BARCL_RS00440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BARCL_RS00445	COG2832	Protein of unknown function (DUF454)
BARCL_RS00450	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BARCL_RS00460	COG0539	negative regulation of cytoplasmic translation
BARCL_RS00465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BARCL_RS00470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BARCL_RS00485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BARCL_RS00495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BARCL_RS00500	COG3030	protein affecting phage T7 exclusion by the F plasmid
BARCL_RS00515	COG2184	nucleotidyltransferase activity
BARCL_RS00530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BARCL_RS00540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BARCL_RS00550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BARCL_RS00555	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BARCL_RS00560	COG4133	protoheme IX ABC transporter activity
BARCL_RS00565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BARCL_RS00570	COG0268	Binds directly to 16S ribosomal RNA
BARCL_RS00575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BARCL_RS00595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BARCL_RS00600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BARCL_RS00605	COG1845	cytochrome c oxidase, subunit III
BARCL_RS00610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BARCL_RS00615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BARCL_RS00625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BARCL_RS00650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BARCL_RS00655	COG1072	(Pantothenic acid kinase))
BARCL_RS00660	COG0252	asparaginase activity
BARCL_RS00665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BARCL_RS00670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BARCL_RS00675	COG2813	Specifically methylates the guanine in position
BARCL_RS00680	COG1185	polyribonucleotide nucleotidyltransferase activity
BARCL_RS00685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BARCL_RS00690	COG2814	Major facilitator Superfamily
BARCL_RS00695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BARCL_RS00700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BARCL_RS00705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BARCL_RS00715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BARCL_RS00715	COG0195	Participates in both transcription termination and antitermination
BARCL_RS00720	COG0779	Required for maturation of 30S ribosomal subunits
BARCL_RS00725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BARCL_RS00730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BARCL_RS00735	COG1396	sequence-specific DNA binding
BARCL_RS00750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BARCL_RS00755	COG1702	phosphate starvation-inducible protein PhoH
BARCL_RS00760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BARCL_RS00770	COG1214	PFAM Peptidase M22, glycoprotease
BARCL_RS00775	COG2855	membrane
BARCL_RS00780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BARCL_RS00785	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BARCL_RS00790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BARCL_RS00795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BARCL_RS00800	COG3474	cytochrome
BARCL_RS00805	COG4174	ABC transporter (Permease)
BARCL_RS00810	COG4239	(ABC) transporter, permease
BARCL_RS00815	COG4172	Belongs to the ABC transporter superfamily
BARCL_RS00825	COG0189	ligase activity
BARCL_RS00835	COG0573	inorganic phosphate transmembrane transporter activity
BARCL_RS00845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BARCL_RS00850	COG0704	Plays a role in the regulation of phosphate uptake
BARCL_RS00865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BARCL_RS00870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BARCL_RS00885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BARCL_RS00890	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BARCL_RS00895	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BARCL_RS00900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BARCL_RS00910	COG0590	tRNA wobble adenosine to inosine editing
BARCL_RS00915	COG1187	pseudouridine synthase activity
BARCL_RS00920	COG0742	ribosomal rna small subunit methyltransferase
BARCL_RS00930	COG0312	modulator of DNA gyrase
BARCL_RS00935	COG0483	inositol monophosphate 1-phosphatase activity
BARCL_RS00950	COG1519	Transferase
BARCL_RS00955	COG1663	tetraacyldisaccharide 4'-kinase activity
BARCL_RS00965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BARCL_RS00970	COG0717	Belongs to the dCTP deaminase family
BARCL_RS00975	COG1304	FMN binding
BARCL_RS00980	COG1268	BioY protein
BARCL_RS00985	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BARCL_RS00990	COG1122	ATPase activity
BARCL_RS00995	COG1113	amino acid transport
BARCL_RS01005	COG2900	Belongs to the SlyX family
BARCL_RS01025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BARCL_RS01035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BARCL_RS01040	COG0564	pseudouridine synthase activity
BARCL_RS01055	COG1970	mechanosensitive ion channel activity
BARCL_RS01060	COG0167	dihydroorotate dehydrogenase activity
BARCL_RS01070	COG0174	glutamine synthetase
BARCL_RS01075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BARCL_RS01080	COG0363	glucosamine-6-phosphate deaminase activity
BARCL_RS01085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BARCL_RS01105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BARCL_RS01110	COG2184	nucleotidyltransferase activity
BARCL_RS01130	COG0166	Belongs to the GPI family
BARCL_RS01145	COG2184	nucleotidyltransferase activity
BARCL_RS01150	COG0588	phosphoglycerate mutase activity
BARCL_RS01155	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BARCL_RS01160	COG2184	nucleotidyltransferase activity
BARCL_RS01170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BARCL_RS01180	COG0594	ribonuclease P activity
BARCL_RS01185	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BARCL_RS01190	COG0489	protein tyrosine kinase activity
BARCL_RS01200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BARCL_RS01205	COG0792	nuclease activity
BARCL_RS01230	COG2086	electron transfer activity
BARCL_RS01240	COG0730	response to heat
BARCL_RS01250	COG1570	exodeoxyribonuclease VII activity
BARCL_RS01255	COG2818	Glycosylase
BARCL_RS01260	COG0747	negative chemotaxis
BARCL_RS01265	COG0747	negative chemotaxis
BARCL_RS01270	COG0601	transmembrane transport
BARCL_RS01275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BARCL_RS01280	COG0444	Belongs to the ABC transporter superfamily
BARCL_RS01335	COG0482	sulfurtransferase activity
BARCL_RS01340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BARCL_RS01375	COG0714	Associated with various cellular activities
BARCL_RS01380	COG0617	tRNA 3'-terminal CCA addition
BARCL_RS01385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BARCL_RS01400	COG0012	GTP binding
BARCL_RS01405	COG1376	ErfK ybiS ycfS ynhG family protein
BARCL_RS01410	COG0193	aminoacyl-tRNA hydrolase activity
BARCL_RS01415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BARCL_RS01445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BARCL_RS01460	COG2205	protein histidine kinase activity
BARCL_RS01465	COG0745	RESPONSE REGULATOR receiver
BARCL_RS01470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BARCL_RS01495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BARCL_RS01505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BARCL_RS01510	COG0492	ferredoxin-NADP+ reductase activity
BARCL_RS01515	COG0583	DNA-binding transcription factor activity
BARCL_RS01520	COG0436	Aminotransferase
BARCL_RS01525	COG1278	Cold shock
BARCL_RS01535	COG0505	Belongs to the CarA family
BARCL_RS01540	COG3161	chorismate lyase activity
BARCL_RS01550	COG0668	transmembrane transport
BARCL_RS01560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BARCL_RS01570	COG2968	Membrane
BARCL_RS01580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BARCL_RS01585	COG0328	RNA-DNA hybrid ribonuclease activity
BARCL_RS01595	COG1678	Uncharacterized ACR, COG1678
BARCL_RS01600	COG1716	ATPase activity
BARCL_RS01600	COG5001	Diguanylate cyclase
BARCL_RS01605	COG0612	Peptidase, M16
BARCL_RS01615	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BARCL_RS01620	COG1194	a g-specific adenine glycosylase
BARCL_RS01630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BARCL_RS01630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BARCL_RS01635	COG0574	Belongs to the PEP-utilizing enzyme family
BARCL_RS01635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BARCL_RS01655	COG0433	COG0433 Predicted ATPase
BARCL_RS01660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BARCL_RS01675	COG2166	iron-sulfur cluster assembly
BARCL_RS01725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BARCL_RS01730	COG1138	Cytochrome C-type biogenesis protein
BARCL_RS01735	COG3088	subunit of a heme lyase
BARCL_RS01740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BARCL_RS01745	COG0745	RESPONSE REGULATOR receiver
BARCL_RS01750	COG0642	Histidine kinase
BARCL_RS01755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BARCL_RS01765	COG2202	Pas domain
BARCL_RS01765	COG2205	protein histidine kinase activity
BARCL_RS01770	COG0308	aminopeptidase N
BARCL_RS01790	COG2022	thiamine diphosphate biosynthetic process
BARCL_RS01805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BARCL_RS01820	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BARCL_RS01825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BARCL_RS01830	COG4558	Periplasmic binding protein
BARCL_RS01835	COG3720	iron ion transport
BARCL_RS01850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BARCL_RS01855	COG0009	L-threonylcarbamoyladenylate synthase
BARCL_RS01860	COG0277	FAD linked oxidase domain protein
BARCL_RS01880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BARCL_RS01885	COG0259	pyridoxamine-phosphate oxidase activity
BARCL_RS01890	COG0484	heat shock protein binding
BARCL_RS01895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BARCL_RS01905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BARCL_RS01905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BARCL_RS01910	COG1722	exodeoxyribonuclease VII activity
BARCL_RS01915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BARCL_RS01925	COG0312	modulator of DNA gyrase
BARCL_RS01935	COG0109	protoheme IX farnesyltransferase activity
BARCL_RS01940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BARCL_RS01950	COG0180	Tryptophanyl-tRNA synthetase
BARCL_RS01955	COG0728	peptidoglycan biosynthetic process
BARCL_RS01965	COG0196	riboflavin kinase activity
BARCL_RS01970	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BARCL_RS02005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BARCL_RS02010	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BARCL_RS02015	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BARCL_RS02025	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BARCL_RS02030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BARCL_RS02040	COG4786	Flagellar basal body rod
BARCL_RS02045	COG1157	protein secretion by the type III secretion system
BARCL_RS02050	COG1815	bacterial-type flagellum-dependent cell motility
BARCL_RS02055	COG1558	bacterial-type flagellum-dependent cell motility
BARCL_RS02060	COG1677	Flagellar hook-basal body complex protein FliE
BARCL_RS02065	COG4786	Flagellar basal body rod
BARCL_RS02070	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
BARCL_RS02075	COG1706	bacterial-type flagellum-dependent cell motility
BARCL_RS02085	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BARCL_RS02095	COG1338	Plays a role in the flagellum-specific transport system
BARCL_RS02130	COG1360	Flagellar Motor Protein
BARCL_RS02180	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BARCL_RS02195	COG4604	ABC transporter, ATP-binding protein
BARCL_RS02200	COG4605	iron ion homeostasis
BARCL_RS02205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BARCL_RS02210	COG4607	ABC-type enterochelin transport system periplasmic component
BARCL_RS02225	COG2011	ABC-type metal ion transport system permease component
BARCL_RS02230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BARCL_RS02245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BARCL_RS02250	COG2835	tetraacyldisaccharide 4'-kinase activity
BARCL_RS02255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BARCL_RS02260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BARCL_RS02265	COG0509	glycine decarboxylation via glycine cleavage system
BARCL_RS02270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BARCL_RS02270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BARCL_RS02285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BARCL_RS02290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BARCL_RS02295	COG1573	uracil-dna glycosylase
BARCL_RS02300	COG1758	RNA polymerase activity
BARCL_RS02310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BARCL_RS02320	COG0736	holo-[acyl-carrier-protein] synthase activity
BARCL_RS02330	COG0571	ribonuclease III activity
BARCL_RS02345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BARCL_RS02350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BARCL_RS02355	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BARCL_RS02360	COG0354	folic acid binding
BARCL_RS02365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BARCL_RS02380	COG0215	cysteine-tRNA ligase activity
BARCL_RS02390	COG5265	(ABC) transporter
BARCL_RS02395	COG0688	phosphatidylethanolamine metabolic process
BARCL_RS02400	COG1183	phosphatidylcholine synthase activity
BARCL_RS02405	COG4221	oxidoreductase activity
BARCL_RS02410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BARCL_RS02425	COG0305	Participates in initiation and elongation during chromosome replication
BARCL_RS02430	COG0359	binds to the 23S rRNA
BARCL_RS02440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BARCL_RS02445	COG0360	Binds together with S18 to 16S ribosomal RNA
BARCL_RS02450	COG0671	phosphoesterase, PA-phosphatase related
BARCL_RS02455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BARCL_RS02465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BARCL_RS02470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BARCL_RS02475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BARCL_RS02480	COG0194	GDP metabolic process
BARCL_RS02485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BARCL_RS02490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BARCL_RS02525	COG0477	Major facilitator Superfamily
BARCL_RS02555	COG0105	UTP biosynthetic process
BARCL_RS02560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BARCL_RS02565	COG0322	excinuclease ABC activity
BARCL_RS02570	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BARCL_RS02580	COG1253	flavin adenine dinucleotide binding
BARCL_RS02590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BARCL_RS02590	COG4651	solute:proton antiporter activity
BARCL_RS02600	COG1196	nuclear chromosome segregation
BARCL_RS02600	COG3264	Mechanosensitive ion channel
BARCL_RS02605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BARCL_RS02610	COG1113	amino acid transport
BARCL_RS02620	COG0149	triose-phosphate isomerase activity
BARCL_RS02630	COG0504	CTP synthase activity
BARCL_RS02635	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BARCL_RS02640	COG0148	phosphopyruvate hydratase activity
BARCL_RS02655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BARCL_RS02660	COG0022	dehydrogenase e1 component
BARCL_RS02660	COG0508	dehydrogenase complex catalyzes the overall conversion of
BARCL_RS02665	COG0508	dehydrogenase complex catalyzes the overall conversion of
BARCL_RS02670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BARCL_RS02675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BARCL_RS02680	COG2867	negative regulation of translational initiation
BARCL_RS02685	COG1546	Belongs to the CinA family
BARCL_RS02685	COG1058	Belongs to the CinA family
BARCL_RS02690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BARCL_RS02690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BARCL_RS02695	COG1959	2 iron, 2 sulfur cluster binding
BARCL_RS02700	COG5000	phosphorelay sensor kinase activity
BARCL_RS02705	COG2204	response regulator
BARCL_RS02710	COG0569	domain protein
BARCL_RS02720	COG0740	serine-type endopeptidase activity
BARCL_RS02725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BARCL_RS02740	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BARCL_RS02750	COG0544	peptidyl-prolyl cis-trans isomerase activity
BARCL_RS02755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BARCL_RS02770	COG0174	glutamine synthetase
BARCL_RS02780	COG3838	Conjugal transfer protein Trbc
BARCL_RS02785	COG3702	type iv secretory pathway
BARCL_RS02790	COG3451	type IV secretory pathway VirB4
BARCL_RS02800	COG3704	protein secretion by the type IV secretion system
BARCL_RS02815	COG3736	Type IV secretory pathway, component VirB8
BARCL_RS02820	COG3504	Conjugal transfer protein
BARCL_RS02825	COG2948	multi-organism process
BARCL_RS02830	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BARCL_RS02835	COG2184	nucleotidyltransferase activity
BARCL_RS02840	COG2184	nucleotidyltransferase activity
BARCL_RS02845	COG2184	nucleotidyltransferase activity
BARCL_RS02850	COG2184	nucleotidyltransferase activity
BARCL_RS02855	COG3505	Type IV secretory pathway VirD4
BARCL_RS02865	COG2184	nucleotidyltransferase activity
BARCL_RS02875	COG2184	nucleotidyltransferase activity
BARCL_RS02880	COG2184	nucleotidyltransferase activity
BARCL_RS02885	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BARCL_RS02890	COG2948	multi-organism process
BARCL_RS02895	COG3504	Conjugal transfer protein
BARCL_RS02900	COG3736	Type IV secretory pathway, component VirB8
BARCL_RS02915	COG3704	protein secretion by the type IV secretion system
BARCL_RS02925	COG3451	type IV secretory pathway VirB4
BARCL_RS02930	COG3702	type iv secretory pathway
BARCL_RS02935	COG3838	Conjugal transfer protein Trbc
BARCL_RS02945	COG0174	glutamine synthetase
BARCL_RS02950	COG0347	Belongs to the P(II) protein family
BARCL_RS02960	COG0629	single-stranded DNA binding
BARCL_RS02965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BARCL_RS02970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BARCL_RS02985	COG0343	queuine tRNA-ribosyltransferase activity
BARCL_RS02990	COG2814	Major facilitator Superfamily
BARCL_RS02995	COG0538	isocitrate dehydrogenase activity
BARCL_RS03010	COG1494	fructose-1,6-bisphosphatase
BARCL_RS03015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BARCL_RS03030	COG0018	arginyl-trna synthetase
BARCL_RS03035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BARCL_RS03040	COG0316	Belongs to the HesB IscA family
BARCL_RS03050	COG0785	Cytochrome C biogenesis protein
BARCL_RS03055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BARCL_RS03060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BARCL_RS03065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BARCL_RS03075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BARCL_RS03085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BARCL_RS03090	COG0248	Ppx GppA phosphatase
BARCL_RS03095	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BARCL_RS03100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BARCL_RS03105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BARCL_RS03110	COG2814	Major facilitator Superfamily
BARCL_RS03120	COG0271	Belongs to the BolA IbaG family
BARCL_RS03125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BARCL_RS03130	COG0047	phosphoribosylformylglycinamidine synthase activity
BARCL_RS03135	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BARCL_RS03140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BARCL_RS03150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BARCL_RS03160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BARCL_RS03175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BARCL_RS03180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BARCL_RS03185	COG0628	permease
BARCL_RS03215	COG0784	Response regulator, receiver
BARCL_RS03220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BARCL_RS03225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BARCL_RS03235	COG0187	DNA topoisomerase II activity
BARCL_RS03240	COG0321	lipoyl(octanoyl) transferase activity
BARCL_RS03245	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BARCL_RS03250	COG1704	LemA family
BARCL_RS03265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BARCL_RS03270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BARCL_RS03275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BARCL_RS03280	COG0649	NAD binding
BARCL_RS03285	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BARCL_RS03290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BARCL_RS03300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BARCL_RS03305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BARCL_RS03315	COG0713	ATP synthesis coupled electron transport
BARCL_RS03330	COG1007	ATP synthesis coupled electron transport
BARCL_RS03335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BARCL_RS03335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BARCL_RS03345	COG0442	prolyl-tRNA aminoacylation
BARCL_RS03350	COG4591	ABC-type transport system involved in lipoprotein release permease component
BARCL_RS03355	COG1136	(ABC) transporter
BARCL_RS03360	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BARCL_RS03365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BARCL_RS03375	COG4166	transmembrane transport
BARCL_RS03390	COG0860	N-Acetylmuramoyl-L-alanine amidase
BARCL_RS03395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BARCL_RS03405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BARCL_RS03410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BARCL_RS03425	COG0024	Methionine aminopeptidase
BARCL_RS03430	COG1489	DNA binding
BARCL_RS03440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BARCL_RS03445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BARCL_RS03450	COG0037	tRNA processing
BARCL_RS03455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BARCL_RS03460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BARCL_RS03475	COG1686	Belongs to the peptidase S11 family
BARCL_RS03480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BARCL_RS03485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BARCL_RS03495	COG0084	hydrolase, TatD family'
BARCL_RS03500	COG0321	lipoyl(octanoyl) transferase activity
BARCL_RS03500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BARCL_RS03505	COG1183	phosphatidylcholine synthase activity
BARCL_RS03510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BARCL_RS03540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BARCL_RS03545	COG0719	Fe-S assembly protein
BARCL_RS03550	COG0396	ATPase activity
BARCL_RS03555	COG0719	Fe-S assembly protein
BARCL_RS03565	COG2945	thiolester hydrolase activity
BARCL_RS03570	COG2267	carboxylic ester hydrolase activity
BARCL_RS03575	COG1278	Cold shock
BARCL_RS03590	COG4177	L-phenylalanine transmembrane transporter activity
BARCL_RS03595	COG0411	ABC transporter
BARCL_RS03605	COG0154	amidase activity
BARCL_RS03610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BARCL_RS03615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BARCL_RS03625	COG0540	Belongs to the ATCase OTCase family
BARCL_RS03630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BARCL_RS03635	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BARCL_RS03640	COG0758	DNA mediated transformation
BARCL_RS03645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BARCL_RS03650	COG0557	exoribonuclease II activity
BARCL_RS03660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BARCL_RS03675	COG1573	uracil-dna glycosylase
BARCL_RS03680	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BARCL_RS03685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BARCL_RS03700	COG0511	ligase activity, forming carbon-carbon bonds
BARCL_RS03715	COG3023	N-Acetylmuramoyl-L-alanine amidase
BARCL_RS03735	COG0302	gtp cyclohydrolase
BARCL_RS03745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BARCL_RS03750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BARCL_RS03760	COG0776	regulation of translation
BARCL_RS03765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BARCL_RS03770	COG0416	fatty acid biosynthetic process
BARCL_RS03785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BARCL_RS03790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BARCL_RS03800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BARCL_RS03800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BARCL_RS03805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BARCL_RS03810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BARCL_RS03820	COG1612	heme a metabolic process
BARCL_RS03830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BARCL_RS03835	COG1923	regulation of RNA biosynthetic process
BARCL_RS03845	COG0280	phosphate acetyltransferase
BARCL_RS03845	COG0281	malic enzyme
BARCL_RS03850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BARCL_RS03855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BARCL_RS03860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BARCL_RS03865	COG1063	alcohol dehydrogenase
BARCL_RS03890	COG0071	Belongs to the small heat shock protein (HSP20) family
BARCL_RS03920	COG2986	histidine ammonia-lyase
BARCL_RS03935	COG0513	Belongs to the DEAD box helicase family
BARCL_RS03940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BARCL_RS03940	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BARCL_RS03965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BARCL_RS03975	COG2333	competence protein COMEC
BARCL_RS03975	COG0658	competence protein
BARCL_RS03980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BARCL_RS03985	COG0372	Belongs to the citrate synthase family
BARCL_RS03990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BARCL_RS03995	COG4215	(ABC) transporter
BARCL_RS04005	COG1126	abc transporter atp-binding protein
BARCL_RS04010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BARCL_RS04015	COG3494	Protein of unknown function (DUF1009)
BARCL_RS04020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BARCL_RS04025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BARCL_RS04030	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BARCL_RS04035	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BARCL_RS04050	COG0233	cytoplasmic translational termination
BARCL_RS04055	COG0528	UMP kinase activity
BARCL_RS04060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BARCL_RS04065	COG0052	Belongs to the universal ribosomal protein uS2 family
BARCL_RS04090	COG1686	Belongs to the peptidase S11 family
BARCL_RS04100	COG1760	l-serine dehydratase
BARCL_RS04110	COG0789	Transcriptional regulator
BARCL_RS04115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BARCL_RS04120	COG0085	RNA polymerase activity
BARCL_RS04125	COG0222	ribosome binding
BARCL_RS04130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BARCL_RS04135	COG0081	regulation of translation
BARCL_RS04140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BARCL_RS04150	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BARCL_RS04160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BARCL_RS04175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BARCL_RS04190	COG1132	(ABC) transporter
BARCL_RS04195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BARCL_RS04200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BARCL_RS04205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BARCL_RS04210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BARCL_RS04215	COG0203	ribosomal protein L17
BARCL_RS04220	COG0202	RNA polymerase activity
BARCL_RS04225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BARCL_RS04230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BARCL_RS04235	COG0563	adenylate kinase activity
BARCL_RS04240	COG0201	protein transport
BARCL_RS04245	COG0200	Binds to the 23S rRNA
BARCL_RS04250	COG1841	ribosomal large subunit assembly
BARCL_RS04255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BARCL_RS04260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BARCL_RS04265	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BARCL_RS04270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BARCL_RS04275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BARCL_RS04280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BARCL_RS04285	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BARCL_RS04290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BARCL_RS04295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BARCL_RS04300	COG0255	Belongs to the universal ribosomal protein uL29 family
BARCL_RS04305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BARCL_RS04310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BARCL_RS04320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BARCL_RS04325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BARCL_RS04330	COG0089	rRNA binding
BARCL_RS04335	COG0088	Forms part of the polypeptide exit tunnel
BARCL_RS04340	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BARCL_RS04350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BARCL_RS04355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BARCL_RS04360	COG0049	tRNA binding
BARCL_RS04365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BARCL_RS04370	COG0708	Exodeoxyribonuclease III
BARCL_RS04380	COG0765	amino acid transport
BARCL_RS04385	COG0765	amino acid transport
BARCL_RS04390	COG1126	abc transporter atp-binding protein
BARCL_RS04395	COG0525	valine-tRNA ligase activity
BARCL_RS04410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BARCL_RS04425	COG0513	Belongs to the DEAD box helicase family
BARCL_RS04455	COG2184	nucleotidyltransferase activity
BARCL_RS04465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BARCL_RS04470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BARCL_RS04475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BARCL_RS04480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BARCL_RS04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BARCL_RS04500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BARCL_RS04505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BARCL_RS04510	COG0477	Major facilitator Superfamily
BARCL_RS04555	COG1999	signal sequence binding
BARCL_RS04565	COG0006	proline dipeptidase activity
BARCL_RS04575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BARCL_RS04585	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BARCL_RS04600	COG0849	cell division
BARCL_RS04610	COG1181	Belongs to the D-alanine--D-alanine ligase family
BARCL_RS04615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BARCL_RS04620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BARCL_RS04625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BARCL_RS04635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BARCL_RS04640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BARCL_RS04665	COG0275	rRNA processing
BARCL_RS04690	COG1335	isochorismatase
BARCL_RS04725	COG0523	cobalamin synthesis protein
BARCL_RS04750	COG1862	Preprotein translocase
BARCL_RS04755	COG4942	peptidase
BARCL_RS04755	COG1388	LysM domain
BARCL_RS04760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BARCL_RS04765	COG2184	nucleotidyltransferase activity
BARCL_RS04790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BARCL_RS04795	COG0805	protein transport
BARCL_RS04800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BARCL_RS04805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BARCL_RS04810	COG1472	Belongs to the glycosyl hydrolase 3 family
BARCL_RS04820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BARCL_RS04840	COG0142	geranyltranstransferase activity
BARCL_RS04855	COG0751	glycine-tRNA ligase activity
BARCL_RS04860	COG2226	methyltransferase
BARCL_RS04870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BARCL_RS04875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BARCL_RS04880	COG0527	aspartate kinase activity
BARCL_RS04885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BARCL_RS04895	COG0471	metal ion transport
BARCL_RS04895	COG3273	potassium ion transport
BARCL_RS04905	COG1160	GTP binding
BARCL_RS04915	COG0356	it plays a direct role in the translocation of protons across the membrane
BARCL_RS04925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BARCL_RS04930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BARCL_RS04940	COG1823	symporter activity
BARCL_RS04945	COG0494	nUDIX hydrolase
BARCL_RS04950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BARCL_RS04955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BARCL_RS04960	COG0653	protein targeting
BARCL_RS04970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BARCL_RS04975	COG2890	protein-(glutamine-N5) methyltransferase activity
BARCL_RS04990	COG1780	Probably involved in ribonucleotide reductase function
BARCL_RS05000	COG1121	(ABC) transporter
BARCL_RS05010	COG0803	Belongs to the bacterial solute-binding protein 9 family
BARCL_RS05020	COG1175	transmembrane transport
BARCL_RS05025	COG0395	ABC-type sugar transport system, permease component
BARCL_RS05030	COG3842	ATPase activity
BARCL_RS05040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BARCL_RS05040	COG0519	Catalyzes the synthesis of GMP from XMP
BARCL_RS05045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BARCL_RS05060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BARCL_RS05075	COG0517	IMP dehydrogenase activity
BARCL_RS05075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BARCL_RS05080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BARCL_RS05085	COG2951	lytic endotransglycosylase activity
BARCL_RS05090	COG0339	signal peptide processing
BARCL_RS05095	COG2239	Acts as a magnesium transporter
BARCL_RS05100	COG1217	gtp-binding protein TYPA
BARCL_RS05105	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BARCL_RS05110	COG1872	DUF167
BARCL_RS05120	COG5342	invasion associated locus B
BARCL_RS05130	COG0793	Belongs to the peptidase S41A family
BARCL_RS05140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BARCL_RS05145	COG0799	negative regulation of ribosome biogenesis
BARCL_RS05150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BARCL_RS05155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BARCL_RS05160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BARCL_RS05165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BARCL_RS05170	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BARCL_RS05215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BARCL_RS05220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BARCL_RS05230	COG3023	N-Acetylmuramoyl-L-alanine amidase
BARCL_RS05295	COG1054	Belongs to the UPF0176 family
BARCL_RS05305	COG2824	Alkylphosphonate utilization operon protein PhnA
BARCL_RS05310	COG0459	protein refolding
BARCL_RS05315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BARCL_RS05325	COG0033	Phosphoglucomutase
BARCL_RS05335	COG0124	histidyl-tRNA synthetase
BARCL_RS05380	COG3920	Histidine kinase
BARCL_RS05395	COG0784	Response regulator, receiver
BARCL_RS05485	COG1783	phage Terminase large subunit
BARCL_RS05500	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BARCL_RS05505	COG0424	maF-like protein
BARCL_RS05510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BARCL_RS05515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BARCL_RS05520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BARCL_RS05530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BARCL_RS05540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BARCL_RS05545	COG1692	metallophosphoesterase
BARCL_RS05555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BARCL_RS05610	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BARCL_RS05620	COG0756	dUTP diphosphatase activity
BARCL_RS05645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BARCL_RS05650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BARCL_RS05655	COG0037	tRNA processing
BARCL_RS05660	COG2885	chlorophyll binding
BARCL_RS05670	COG0217	transcriptional regulatory protein
BARCL_RS05675	COG0254	rRNA binding
BARCL_RS05680	COG1132	(ABC) transporter
BARCL_RS05685	COG0483	inositol monophosphate 1-phosphatase activity
BARCL_RS05690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BARCL_RS05715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BARCL_RS05720	COG0632	four-way junction helicase activity
BARCL_RS05725	COG2255	four-way junction helicase activity
BARCL_RS05730	COG0824	Thioesterase
BARCL_RS05750	COG0823	Involved in the tonB-independent uptake of proteins
BARCL_RS05760	COG3588	fructose-bisphosphate aldolase
BARCL_RS05765	COG0126	phosphoglycerate kinase activity
BARCL_RS05795	COG3750	Belongs to the UPF0335 family
BARCL_RS05800	COG0488	(ABC) transporter
BARCL_RS05820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BARCL_RS05830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BARCL_RS05840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BARCL_RS05850	COG0142	geranyltranstransferase activity
BARCL_RS05855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BARCL_RS05875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BARCL_RS05880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BARCL_RS05885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BARCL_RS05890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BARCL_RS05895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BARCL_RS05910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BARCL_RS05920	COG0495	leucyl-tRNA aminoacylation
BARCL_RS05925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BARCL_RS05935	COG2884	Cell division ATP-binding protein ftsE
BARCL_RS05950	COG1136	(ABC) transporter
BARCL_RS05950	COG0577	efflux transmembrane transporter activity
BARCL_RS05955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BARCL_RS05975	COG1674	ftsk spoiiie
BARCL_RS05980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BARCL_RS06005	COG0335	large ribosomal subunit rRNA binding
BARCL_RS06010	COG0336	Belongs to the RNA methyltransferase TrmD family
BARCL_RS06015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BARCL_RS06050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BARCL_RS06055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BARCL_RS06065	COG0138	bifunctional purine biosynthesis protein purh
BARCL_RS06075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BARCL_RS06075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BARCL_RS06080	COG0501	Belongs to the peptidase M48B family
BARCL_RS06090	COG0228	four-way junction DNA binding
BARCL_RS06100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BARCL_RS06105	COG0288	reversible hydration of carbon dioxide
BARCL_RS06110	COG2902	Dehydrogenase
BARCL_RS06135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BARCL_RS06140	COG0165	Argininosuccinate lyase
BARCL_RS06165	COG0745	RESPONSE REGULATOR receiver
BARCL_RS06180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BARCL_RS06215	COG1686	Belongs to the peptidase S11 family
BARCL_RS06220	COG0523	cobalamin synthesis protein
BARCL_RS06225	COG3034	peptidoglycan biosynthetic process
BARCL_RS06230	COG0825	malonyl-CoA metabolic process
BARCL_RS06275	COG0019	diaminopimelate decarboxylase activity
BARCL_RS06290	COG0508	dehydrogenase complex catalyzes the overall conversion of
BARCL_RS06295	COG0567	Dehydrogenase, E1 component
BARCL_RS06300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BARCL_RS06305	COG0045	succinate-CoA ligase (ADP-forming) activity
BARCL_RS06310	COG0039	L-malate dehydrogenase activity
BARCL_RS06315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BARCL_RS06330	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BARCL_RS06335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BARCL_RS06340	COG0552	protein localization to endoplasmic reticulum
BARCL_RS06350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BARCL_RS06365	COG0357	Ribosomal RNA small subunit methyltransferase G
BARCL_RS06370	COG0445	tRNA wobble uridine modification
BARCL_RS06375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BARCL_RS06380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BARCL_RS06390	COG2184	nucleotidyltransferase activity
BARCL_RS06400	COG0488	(ABC) transporter