locus-tag	class	description
K8O99_RS00030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K8O99_RS00035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K8O99_RS00040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K8O99_RS00045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K8O99_RS00050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K8O99_RS00055	COG0799	negative regulation of ribosome biogenesis
K8O99_RS00060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K8O99_RS00070	COG0793	Belongs to the peptidase S41A family
K8O99_RS00075	COG0494	nUDIX hydrolase
K8O99_RS00080	COG5342	invasion associated locus B
K8O99_RS00090	COG1872	DUF167
K8O99_RS00095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K8O99_RS00100	COG1217	gtp-binding protein TYPA
K8O99_RS00105	COG2239	Acts as a magnesium transporter
K8O99_RS00110	COG0339	signal peptide processing
K8O99_RS00120	COG2951	lytic endotransglycosylase activity
K8O99_RS00125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K8O99_RS00130	COG0517	IMP dehydrogenase activity
K8O99_RS00130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K8O99_RS00145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8O99_RS00165	COG0519	Catalyzes the synthesis of GMP from XMP
K8O99_RS00165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K8O99_RS00170	COG0584	glycerophosphoryl diester phosphodiesterase
K8O99_RS00175	COG3842	ATPase activity
K8O99_RS00180	COG0395	ABC-type sugar transport system, permease component
K8O99_RS00185	COG1175	transmembrane transport
K8O99_RS00195	COG0803	Belongs to the bacterial solute-binding protein 9 family
K8O99_RS00200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K8O99_RS00205	COG1121	(ABC) transporter
K8O99_RS00215	COG1780	Probably involved in ribonucleotide reductase function
K8O99_RS00220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8O99_RS00230	COG2890	protein-(glutamine-N5) methyltransferase activity
K8O99_RS00235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K8O99_RS00245	COG0653	protein targeting
K8O99_RS00250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8O99_RS00255	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K8O99_RS00260	COG0494	nUDIX hydrolase
K8O99_RS00270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K8O99_RS00275	COG1072	(Pantothenic acid kinase))
K8O99_RS00280	COG0252	asparaginase activity
K8O99_RS00285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K8O99_RS00290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K8O99_RS00295	COG2813	Specifically methylates the guanine in position
K8O99_RS00300	COG1185	polyribonucleotide nucleotidyltransferase activity
K8O99_RS00305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K8O99_RS00315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K8O99_RS00320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K8O99_RS00325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K8O99_RS00335	COG0195	Participates in both transcription termination and antitermination
K8O99_RS00335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K8O99_RS00340	COG0779	Required for maturation of 30S ribosomal subunits
K8O99_RS00345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K8O99_RS00350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K8O99_RS00355	COG1396	sequence-specific DNA binding
K8O99_RS00360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K8O99_RS00370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K8O99_RS00375	COG1702	phosphate starvation-inducible protein PhoH
K8O99_RS00380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8O99_RS00390	COG1214	PFAM Peptidase M22, glycoprotease
K8O99_RS00395	COG2855	membrane
K8O99_RS00400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K8O99_RS00405	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K8O99_RS00410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K8O99_RS00425	COG0077	Prephenate dehydratase
K8O99_RS00425	COG1605	Chorismate mutase
K8O99_RS00430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K8O99_RS00435	COG3474	cytochrome
K8O99_RS00440	COG4174	ABC transporter (Permease)
K8O99_RS00445	COG4239	(ABC) transporter, permease
K8O99_RS00450	COG4172	Belongs to the ABC transporter superfamily
K8O99_RS00465	COG0189	ligase activity
K8O99_RS00475	COG0573	inorganic phosphate transmembrane transporter activity
K8O99_RS00485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K8O99_RS00490	COG0704	Plays a role in the regulation of phosphate uptake
K8O99_RS00510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K8O99_RS00530	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K8O99_RS00535	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K8O99_RS00540	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K8O99_RS00545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K8O99_RS00555	COG0590	tRNA wobble adenosine to inosine editing
K8O99_RS00560	COG1187	pseudouridine synthase activity
K8O99_RS00565	COG0742	ribosomal rna small subunit methyltransferase
K8O99_RS00570	COG0312	modulator of DNA gyrase
K8O99_RS00575	COG0483	inositol monophosphate 1-phosphatase activity
K8O99_RS00585	COG1519	Transferase
K8O99_RS00590	COG1663	tetraacyldisaccharide 4'-kinase activity
K8O99_RS00600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K8O99_RS00605	COG0717	Belongs to the dCTP deaminase family
K8O99_RS00610	COG1304	FMN binding
K8O99_RS00630	COG1113	amino acid transport
K8O99_RS00635	COG1122	ATPase activity
K8O99_RS00645	COG1268	BioY protein
K8O99_RS00685	COG0582	viral genome integration into host DNA
K8O99_RS00690	COG3561	AntA/AntB antirepressor
K8O99_RS00695	COG3077	Addiction module antitoxin, RelB DinJ family
K8O99_RS00700	COG3041	Addiction module toxin RelE StbE family
K8O99_RS00740	COG3561	AntA/AntB antirepressor
K8O99_RS00745	COG3561	AntA/AntB antirepressor
K8O99_RS00870	COG3561	AntA/AntB antirepressor
K8O99_RS00935	COG3077	Addiction module antitoxin, RelB DinJ family
K8O99_RS00940	COG3041	Addiction module toxin RelE StbE family
K8O99_RS00950	COG3561	AntA/AntB antirepressor
K8O99_RS00955	COG3561	AntA/AntB antirepressor
K8O99_RS00995	COG0629	single-stranded DNA binding
K8O99_RS01005	COG3093	addiction module antidote protein HigA
K8O99_RS01065	COG3561	AntA/AntB antirepressor
K8O99_RS01070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K8O99_RS01100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K8O99_RS01110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8O99_RS01115	COG0564	pseudouridine synthase activity
K8O99_RS01140	COG1970	mechanosensitive ion channel activity
K8O99_RS01145	COG0167	dihydroorotate dehydrogenase activity
K8O99_RS01160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8O99_RS01165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K8O99_RS01170	COG0363	glucosamine-6-phosphate deaminase activity
K8O99_RS01175	COG0129	dihydroxy-acid dehydratase activity
K8O99_RS01180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K8O99_RS01205	COG1823	symporter activity
K8O99_RS01210	COG2226	methyltransferase
K8O99_RS01215	COG1040	competence protein
K8O99_RS01220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K8O99_RS01225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K8O99_RS01230	COG0527	aspartate kinase activity
K8O99_RS01235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K8O99_RS01245	COG0471	metal ion transport
K8O99_RS01245	COG3273	potassium ion transport
K8O99_RS01255	COG1160	GTP binding
K8O99_RS01270	COG0356	it plays a direct role in the translocation of protons across the membrane
K8O99_RS01280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K8O99_RS01285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K8O99_RS01290	COG0751	glycine-tRNA ligase activity
K8O99_RS01305	COG0142	geranyltranstransferase activity
K8O99_RS01320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K8O99_RS01330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K8O99_RS01335	COG0009	L-threonylcarbamoyladenylate synthase
K8O99_RS01340	COG0277	FAD linked oxidase domain protein
K8O99_RS01355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K8O99_RS01360	COG0259	pyridoxamine-phosphate oxidase activity
K8O99_RS01365	COG0484	heat shock protein binding
K8O99_RS01370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K8O99_RS01375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K8O99_RS01380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8O99_RS01380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8O99_RS01385	COG1722	exodeoxyribonuclease VII activity
K8O99_RS01390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K8O99_RS01405	COG0312	modulator of DNA gyrase
K8O99_RS01415	COG0109	protoheme IX farnesyltransferase activity
K8O99_RS01420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K8O99_RS01425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8O99_RS01430	COG0328	RNA-DNA hybrid ribonuclease activity
K8O99_RS01440	COG1678	Uncharacterized ACR, COG1678
K8O99_RS01450	COG0612	Peptidase, M16
K8O99_RS01480	COG2189	Belongs to the N(4) N(6)-methyltransferase family
K8O99_RS01485	COG1194	a g-specific adenine glycosylase
K8O99_RS01495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K8O99_RS01495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K8O99_RS01500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K8O99_RS01500	COG0574	Belongs to the PEP-utilizing enzyme family
K8O99_RS01515	COG2166	iron-sulfur cluster assembly
K8O99_RS01530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K8O99_RS01555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K8O99_RS01580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K8O99_RS01585	COG1138	Cytochrome C-type biogenesis protein
K8O99_RS01590	COG3088	subunit of a heme lyase
K8O99_RS01595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8O99_RS01600	COG0745	RESPONSE REGULATOR receiver
K8O99_RS01605	COG0642	Histidine kinase
K8O99_RS01610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K8O99_RS01615	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K8O99_RS01625	COG2202	Pas domain
K8O99_RS01625	COG2205	protein histidine kinase activity
K8O99_RS01630	COG0308	aminopeptidase N
K8O99_RS01640	COG0351	phosphomethylpyrimidine kinase
K8O99_RS01650	COG2022	thiamine diphosphate biosynthetic process
K8O99_RS01665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K8O99_RS01675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K8O99_RS01680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8O99_RS01685	COG4558	Periplasmic binding protein
K8O99_RS01690	COG3720	iron ion transport
K8O99_RS01695	COG4771	TonB-dependent receptor
K8O99_RS01705	COG0741	lytic transglycosylase activity
K8O99_RS01710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K8O99_RS01715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K8O99_RS01720	COG1573	uracil-dna glycosylase
K8O99_RS01725	COG1758	RNA polymerase activity
K8O99_RS01735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K8O99_RS01745	COG0736	holo-[acyl-carrier-protein] synthase activity
K8O99_RS01755	COG0571	ribonuclease III activity
K8O99_RS01765	COG1381	Involved in DNA repair and RecF pathway recombination
K8O99_RS01770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K8O99_RS01775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K8O99_RS01780	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K8O99_RS01785	COG0354	folic acid binding
K8O99_RS01790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K8O99_RS01800	COG0215	cysteine-tRNA ligase activity
K8O99_RS01805	COG2323	membrane
K8O99_RS01810	COG5265	(ABC) transporter
K8O99_RS01815	COG0688	phosphatidylethanolamine metabolic process
K8O99_RS01820	COG1183	phosphatidylcholine synthase activity
K8O99_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
K8O99_RS01830	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K8O99_RS01845	COG0305	Participates in initiation and elongation during chromosome replication
K8O99_RS01850	COG0359	binds to the 23S rRNA
K8O99_RS01860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K8O99_RS01865	COG0360	Binds together with S18 to 16S ribosomal RNA
K8O99_RS01870	COG0671	phosphoesterase, PA-phosphatase related
K8O99_RS01875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K8O99_RS01885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8O99_RS01890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K8O99_RS01895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K8O99_RS01900	COG0194	GDP metabolic process
K8O99_RS01905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K8O99_RS01910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K8O99_RS01920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K8O99_RS01950	COG0477	Major facilitator Superfamily
K8O99_RS01970	COG0488	(ABC) transporter
K8O99_RS01975	COG0105	UTP biosynthetic process
K8O99_RS01980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K8O99_RS01985	COG0322	excinuclease ABC activity
K8O99_RS01990	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K8O99_RS02010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K8O99_RS02015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K8O99_RS02020	COG0805	protein transport
K8O99_RS02025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K8O99_RS02030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K8O99_RS02035	COG4942	peptidase
K8O99_RS02035	COG1388	LysM domain
K8O99_RS02040	COG1862	Preprotein translocase
K8O99_RS02060	COG0149	triose-phosphate isomerase activity
K8O99_RS02070	COG0504	CTP synthase activity
K8O99_RS02075	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K8O99_RS02080	COG0148	phosphopyruvate hydratase activity
K8O99_RS02100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K8O99_RS02105	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8O99_RS02105	COG0022	dehydrogenase e1 component
K8O99_RS02110	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8O99_RS02115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8O99_RS02120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K8O99_RS02125	COG2867	negative regulation of translational initiation
K8O99_RS02130	COG1546	Belongs to the CinA family
K8O99_RS02130	COG1058	Belongs to the CinA family
K8O99_RS02135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K8O99_RS02135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K8O99_RS02140	COG1959	2 iron, 2 sulfur cluster binding
K8O99_RS02145	COG5000	phosphorelay sensor kinase activity
K8O99_RS02150	COG2204	response regulator
K8O99_RS02155	COG0569	domain protein
K8O99_RS02165	COG0740	serine-type endopeptidase activity
K8O99_RS02170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K8O99_RS02185	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K8O99_RS02195	COG0544	peptidyl-prolyl cis-trans isomerase activity
K8O99_RS02200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K8O99_RS02210	COG4765	Protein conserved in bacteria
K8O99_RS02220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8O99_RS02235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K8O99_RS02240	COG0051	transcription antitermination factor activity, RNA binding
K8O99_RS02245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K8O99_RS02250	COG0088	Forms part of the polypeptide exit tunnel
K8O99_RS02255	COG0089	rRNA binding
K8O99_RS02260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K8O99_RS02265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K8O99_RS02270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K8O99_RS02275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K8O99_RS02280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K8O99_RS02285	COG0255	Belongs to the universal ribosomal protein uL29 family
K8O99_RS02290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K8O99_RS02295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K8O99_RS02300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K8O99_RS02305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K8O99_RS02310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K8O99_RS02315	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K8O99_RS02320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K8O99_RS02325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K8O99_RS02330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K8O99_RS02335	COG1841	ribosomal large subunit assembly
K8O99_RS02340	COG0200	Binds to the 23S rRNA
K8O99_RS02350	COG0563	adenylate kinase activity
K8O99_RS02355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K8O99_RS02360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K8O99_RS02365	COG0202	RNA polymerase activity
K8O99_RS02370	COG0203	ribosomal protein L17
K8O99_RS02375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8O99_RS02380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K8O99_RS02385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K8O99_RS02390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K8O99_RS02395	COG1132	(ABC) transporter
K8O99_RS02420	COG0174	glutamine synthetase
K8O99_RS02425	COG0347	Belongs to the P(II) protein family
K8O99_RS02435	COG0629	single-stranded DNA binding
K8O99_RS02440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K8O99_RS02445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K8O99_RS02460	COG0343	queuine tRNA-ribosyltransferase activity
K8O99_RS02465	COG2814	Major facilitator Superfamily
K8O99_RS02475	COG0538	isocitrate dehydrogenase activity
K8O99_RS02495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8O99_RS02510	COG0018	arginyl-trna synthetase
K8O99_RS02515	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K8O99_RS02520	COG0316	Belongs to the HesB IscA family
K8O99_RS02530	COG0785	Cytochrome C biogenesis protein
K8O99_RS02535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K8O99_RS02540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K8O99_RS02555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K8O99_RS02565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8O99_RS02575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K8O99_RS02580	COG0248	Ppx GppA phosphatase
K8O99_RS02585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K8O99_RS02590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K8O99_RS02595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K8O99_RS02600	COG2814	Major facilitator Superfamily
K8O99_RS02605	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K8O99_RS02615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K8O99_RS02620	COG0047	phosphoribosylformylglycinamidine synthase activity
K8O99_RS02625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K8O99_RS02630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K8O99_RS02640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K8O99_RS02650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K8O99_RS02690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K8O99_RS02695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K8O99_RS02700	COG0628	permease
K8O99_RS02730	COG3093	addiction module antidote protein HigA
K8O99_RS02740	COG0629	single-stranded DNA binding
K8O99_RS02780	COG2831	hemolysin activation secretion protein
K8O99_RS02785	COG3210	domain, Protein
K8O99_RS02785	COG3210	domain, Protein
K8O99_RS02865	COG0582	viral genome integration into host DNA
K8O99_RS02885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K8O99_RS02950	COG0629	single-stranded DNA binding
K8O99_RS03190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O99_RS03195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O99_RS03200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O99_RS03205	COG0649	NAD binding
K8O99_RS03210	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K8O99_RS03215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K8O99_RS03225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K8O99_RS03230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8O99_RS03240	COG0713	ATP synthesis coupled electron transport
K8O99_RS03255	COG1007	ATP synthesis coupled electron transport
K8O99_RS03270	COG0442	prolyl-tRNA aminoacylation
K8O99_RS03280	COG1136	(ABC) transporter
K8O99_RS03285	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K8O99_RS03290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K8O99_RS03295	COG4166	transmembrane transport
K8O99_RS03305	COG1530	ribonuclease E activity
K8O99_RS03310	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8O99_RS03315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K8O99_RS03325	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K8O99_RS03330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K8O99_RS03335	COG2945	thiolester hydrolase activity
K8O99_RS03345	COG0719	Fe-S assembly protein
K8O99_RS03350	COG0396	ATPase activity
K8O99_RS03355	COG0719	Fe-S assembly protein
K8O99_RS03360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K8O99_RS03370	COG2032	superoxide dismutase activity
K8O99_RS03385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8O99_RS03390	COG1183	phosphatidylcholine synthase activity
K8O99_RS03405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K8O99_RS03405	COG0321	lipoyl(octanoyl) transferase activity
K8O99_RS03410	COG0084	hydrolase, TatD family'
K8O99_RS03415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8O99_RS03425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K8O99_RS03430	COG1686	Belongs to the peptidase S11 family
K8O99_RS03445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K8O99_RS03450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8O99_RS03455	COG0037	tRNA processing
K8O99_RS03460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K8O99_RS03465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K8O99_RS03475	COG1489	DNA binding
K8O99_RS03480	COG0024	Methionine aminopeptidase
K8O99_RS03485	COG2003	Belongs to the UPF0758 family
K8O99_RS03495	COG0596	Alpha beta hydrolase
K8O99_RS03505	COG1278	Cold shock
K8O99_RS03535	COG0154	amidase activity
K8O99_RS03540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K8O99_RS03545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K8O99_RS03555	COG0540	Belongs to the ATCase OTCase family
K8O99_RS03560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K8O99_RS03565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K8O99_RS03570	COG0758	DNA mediated transformation
K8O99_RS03580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K8O99_RS03585	COG0557	exoribonuclease II activity
K8O99_RS03590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K8O99_RS03600	COG1573	uracil-dna glycosylase
K8O99_RS03605	COG1522	sequence-specific DNA binding
K8O99_RS03630	COG0511	ligase activity, forming carbon-carbon bonds
K8O99_RS03675	COG3210	domain, Protein
K8O99_RS03680	COG2831	hemolysin activation secretion protein
K8O99_RS03710	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K8O99_RS03715	COG0321	lipoyl(octanoyl) transferase activity
K8O99_RS03720	COG0187	DNA topoisomerase II activity
K8O99_RS03725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K8O99_RS03730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K8O99_RS03735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K8O99_RS03740	COG0784	Response regulator, receiver
K8O99_RS03785	COG0302	gtp cyclohydrolase
K8O99_RS03795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K8O99_RS03800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K8O99_RS03810	COG0776	regulation of translation
K8O99_RS03815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8O99_RS03820	COG0416	fatty acid biosynthetic process
K8O99_RS03835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8O99_RS03840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K8O99_RS03850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8O99_RS03850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8O99_RS03855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K8O99_RS03860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K8O99_RS03870	COG1612	heme a metabolic process
K8O99_RS03880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K8O99_RS03885	COG1923	regulation of RNA biosynthetic process
K8O99_RS03895	COG0280	phosphate acetyltransferase
K8O99_RS03895	COG0281	malic enzyme
K8O99_RS03900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8O99_RS03910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K8O99_RS03915	COG1063	alcohol dehydrogenase
K8O99_RS03925	COG3956	TIGRFAM MazG family protein
K8O99_RS03930	COG0316	Belongs to the HesB IscA family
K8O99_RS03960	COG0071	Belongs to the small heat shock protein (HSP20) family
K8O99_RS04035	COG3210	domain, Protein
K8O99_RS04035	COG3210	domain, Protein
K8O99_RS04040	COG2831	hemolysin activation secretion protein
K8O99_RS04095	COG3210	domain, Protein
K8O99_RS04095	COG3210	domain, Protein
K8O99_RS04100	COG2831	hemolysin activation secretion protein
K8O99_RS04120	COG2986	histidine ammonia-lyase
K8O99_RS04135	COG0513	Belongs to the DEAD box helicase family
K8O99_RS04140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K8O99_RS04140	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K8O99_RS04150	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K8O99_RS04165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K8O99_RS04175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K8O99_RS04180	COG0372	Belongs to the citrate synthase family
K8O99_RS04190	COG4215	(ABC) transporter
K8O99_RS04200	COG1126	abc transporter atp-binding protein
K8O99_RS04205	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O99_RS04210	COG3494	Protein of unknown function (DUF1009)
K8O99_RS04215	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O99_RS04220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8O99_RS04225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K8O99_RS04235	COG0750	zinc metalloprotease
K8O99_RS04245	COG0233	cytoplasmic translational termination
K8O99_RS04250	COG0528	UMP kinase activity
K8O99_RS04255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K8O99_RS04260	COG0052	Belongs to the universal ribosomal protein uS2 family
K8O99_RS04285	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K8O99_RS04290	COG1686	Belongs to the peptidase S11 family
K8O99_RS04300	COG1760	l-serine dehydratase
K8O99_RS04310	COG0789	Transcriptional regulator
K8O99_RS04315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K8O99_RS04320	COG0085	RNA polymerase activity
K8O99_RS04325	COG0222	ribosome binding
K8O99_RS04330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K8O99_RS04335	COG0081	regulation of translation
K8O99_RS04340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K8O99_RS04350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K8O99_RS04360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K8O99_RS04365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K8O99_RS04370	COG0049	tRNA binding
K8O99_RS04375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K8O99_RS04390	COG0765	amino acid transport
K8O99_RS04395	COG0765	amino acid transport
K8O99_RS04400	COG1126	abc transporter atp-binding protein
K8O99_RS04410	COG0525	valine-tRNA ligase activity
K8O99_RS04425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K8O99_RS04470	COG0513	Belongs to the DEAD box helicase family
K8O99_RS04475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K8O99_RS04495	COG3264	Mechanosensitive ion channel
K8O99_RS04495	COG1196	nuclear chromosome segregation
K8O99_RS04510	COG4651	solute:proton antiporter activity
K8O99_RS04510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K8O99_RS04520	COG1253	flavin adenine dinucleotide binding
K8O99_RS04530	COG1113	amino acid transport
K8O99_RS04535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K8O99_RS04545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K8O99_RS04550	COG0028	Belongs to the TPP enzyme family
K8O99_RS04555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K8O99_RS04565	COG0330	HflC and HflK could
K8O99_RS04575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K8O99_RS04580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K8O99_RS04585	COG0477	Major facilitator Superfamily
K8O99_RS04590	COG0477	Major facilitator Superfamily
K8O99_RS04595	COG0477	Major facilitator Superfamily
K8O99_RS04625	COG0210	DNA helicase
K8O99_RS04635	COG1999	signal sequence binding
K8O99_RS04645	COG0006	proline dipeptidase activity
K8O99_RS04650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K8O99_RS04655	COG0497	DNA recombination
K8O99_RS04660	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K8O99_RS04675	COG0849	cell division
K8O99_RS04685	COG1181	Belongs to the D-alanine--D-alanine ligase family
K8O99_RS04690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K8O99_RS04695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K8O99_RS04700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K8O99_RS04710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K8O99_RS04715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8O99_RS04725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K8O99_RS04740	COG0275	rRNA processing
K8O99_RS04750	COG0741	lytic transglycosylase activity
K8O99_RS04775	COG1335	isochorismatase
K8O99_RS04820	COG2968	Membrane
K8O99_RS04825	COG2983	Belongs to the UPF0260 family
K8O99_RS04830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8O99_RS04840	COG0668	transmembrane transport
K8O99_RS04855	COG3161	chorismate lyase activity
K8O99_RS04860	COG0505	Belongs to the CarA family
K8O99_RS04880	COG1278	Cold shock
K8O99_RS04885	COG0436	Aminotransferase
K8O99_RS04890	COG0583	DNA-binding transcription factor activity
K8O99_RS04895	COG0492	ferredoxin-NADP+ reductase activity
K8O99_RS04900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8O99_RS04915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K8O99_RS04925	COG0556	nucleotide-excision repair
K8O99_RS04935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8O99_RS04940	COG0745	RESPONSE REGULATOR receiver
K8O99_RS04945	COG2205	protein histidine kinase activity
K8O99_RS04960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K8O99_RS04970	COG1496	oxidoreductase activity
K8O99_RS04985	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K8O99_RS04990	COG0193	aminoacyl-tRNA hydrolase activity
K8O99_RS04995	COG1376	ErfK ybiS ycfS ynhG family protein
K8O99_RS05000	COG0012	GTP binding
K8O99_RS05020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K8O99_RS05030	COG0714	Associated with various cellular activities
K8O99_RS05055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K8O99_RS05065	COG0482	sulfurtransferase activity
K8O99_RS05135	COG0444	Belongs to the ABC transporter superfamily
K8O99_RS05140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8O99_RS05145	COG0601	transmembrane transport
K8O99_RS05150	COG0747	negative chemotaxis
K8O99_RS05155	COG0747	negative chemotaxis
K8O99_RS05160	COG0519	Catalyzes the synthesis of GMP from XMP
K8O99_RS05165	COG1570	exodeoxyribonuclease VII activity
K8O99_RS05170	COG0747	negative chemotaxis
K8O99_RS05190	COG0730	response to heat
K8O99_RS05200	COG2086	electron transfer activity
K8O99_RS05230	COG0792	nuclease activity
K8O99_RS05235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K8O99_RS05240	COG0489	protein tyrosine kinase activity
K8O99_RS05245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K8O99_RS05250	COG0594	ribonuclease P activity
K8O99_RS05260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K8O99_RS05270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K8O99_RS05275	COG0588	phosphoglycerate mutase activity
K8O99_RS05285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K8O99_RS05305	COG3023	N-Acetylmuramoyl-L-alanine amidase
K8O99_RS05315	COG1058	Belongs to the CinA family
K8O99_RS05315	COG1546	Belongs to the CinA family
K8O99_RS05320	COG0473	3-isopropylmalate dehydrogenase activity
K8O99_RS05320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K8O99_RS05335	COG2814	Major facilitator Superfamily
K8O99_RS05405	COG0735	belongs to the Fur family
K8O99_RS05440	COG1054	Belongs to the UPF0176 family
K8O99_RS05445	COG0800	Aldolase
K8O99_RS05485	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K8O99_RS05485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K8O99_RS05490	COG0509	glycine decarboxylation via glycine cleavage system
K8O99_RS05495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K8O99_RS05505	COG2835	tetraacyldisaccharide 4'-kinase activity
K8O99_RS05510	COG1396	sequence-specific DNA binding
K8O99_RS05515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K8O99_RS05530	COG1464	Belongs to the NlpA lipoprotein family
K8O99_RS05535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K8O99_RS05540	COG2011	ABC-type metal ion transport system permease component
K8O99_RS05675	COG1192	Involved in chromosome partitioning
K8O99_RS05685	COG0196	riboflavin kinase activity
K8O99_RS05710	COG3838	Conjugal transfer protein Trbc
K8O99_RS05715	COG3702	type iv secretory pathway
K8O99_RS05720	COG3451	type IV secretory pathway VirB4
K8O99_RS05730	COG3704	protein secretion by the type IV secretion system
K8O99_RS05740	COG3736	Type IV secretory pathway, component VirB8
K8O99_RS05745	COG3504	Conjugal transfer protein
K8O99_RS05750	COG2948	multi-organism process
K8O99_RS05755	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
K8O99_RS05765	COG2184	nucleotidyltransferase activity
K8O99_RS05770	COG3505	Type IV secretory pathway VirD4
K8O99_RS05775	COG2184	nucleotidyltransferase activity
K8O99_RS05785	COG2184	nucleotidyltransferase activity
K8O99_RS05815	COG0728	peptidoglycan biosynthetic process
K8O99_RS05820	COG0180	Tryptophanyl-tRNA synthetase
K8O99_RS05830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K8O99_RS05835	COG2824	Alkylphosphonate utilization operon protein PhnA
K8O99_RS05840	COG0459	protein refolding
K8O99_RS05845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K8O99_RS05860	COG0033	Phosphoglucomutase
K8O99_RS05890	COG0124	histidyl-tRNA synthetase
K8O99_RS05900	COG0284	orotidine-5'-phosphate decarboxylase activity
K8O99_RS05965	COG0739	heme binding
K8O99_RS05975	COG3920	Histidine kinase
K8O99_RS05990	COG0784	Response regulator, receiver
K8O99_RS06130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K8O99_RS06135	COG0424	maF-like protein
K8O99_RS06140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K8O99_RS06145	COG1396	sequence-specific DNA binding
K8O99_RS06155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K8O99_RS06165	COG1396	sequence-specific DNA binding
K8O99_RS06205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K8O99_RS06215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K8O99_RS06230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K8O99_RS06235	COG0457	Tetratricopeptide repeat
K8O99_RS06250	COG1396	sequence-specific DNA binding
K8O99_RS06255	COG1396	sequence-specific DNA binding
K8O99_RS06280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K8O99_RS06440	COG0756	dUTP diphosphatase activity
K8O99_RS06455	COG0848	biopolymer transport protein
K8O99_RS06480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K8O99_RS06485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K8O99_RS06490	COG0037	tRNA processing
K8O99_RS06500	COG2885	chlorophyll binding
K8O99_RS06510	COG0217	transcriptional regulatory protein
K8O99_RS06525	COG0823	Involved in the tonB-independent uptake of proteins
K8O99_RS06545	COG0824	Thioesterase
K8O99_RS06550	COG2255	four-way junction helicase activity
K8O99_RS06555	COG0632	four-way junction helicase activity
K8O99_RS06560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K8O99_RS06585	COG1396	sequence-specific DNA binding
K8O99_RS06590	COG1396	sequence-specific DNA binding
K8O99_RS06610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K8O99_RS06615	COG0483	inositol monophosphate 1-phosphatase activity
K8O99_RS06620	COG1132	(ABC) transporter
K8O99_RS06625	COG0254	rRNA binding
K8O99_RS06635	COG3588	fructose-bisphosphate aldolase
K8O99_RS06640	COG0126	phosphoglycerate kinase activity
K8O99_RS06670	COG0469	pyruvate kinase activity
K8O99_RS06680	COG3750	Belongs to the UPF0335 family
K8O99_RS06695	COG0488	(ABC) transporter
K8O99_RS06715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8O99_RS06725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K8O99_RS06735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K8O99_RS06740	COG0142	geranyltranstransferase activity
K8O99_RS06770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K8O99_RS06780	COG1566	PFAM secretion protein HlyD family protein
K8O99_RS06790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K8O99_RS06795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K8O99_RS06800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K8O99_RS06805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K8O99_RS06810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K8O99_RS06825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K8O99_RS06845	COG0495	leucyl-tRNA aminoacylation
K8O99_RS06855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K8O99_RS06860	COG2884	Cell division ATP-binding protein ftsE
K8O99_RS06880	COG0577	efflux transmembrane transporter activity
K8O99_RS06880	COG1136	(ABC) transporter
K8O99_RS06885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O99_RS06890	COG1538	Outer membrane efflux protein
K8O99_RS06905	COG1674	ftsk spoiiie
K8O99_RS06910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8O99_RS07015	COG3504	Conjugal transfer protein
K8O99_RS07055	COG0335	large ribosomal subunit rRNA binding
K8O99_RS07060	COG0336	Belongs to the RNA methyltransferase TrmD family
K8O99_RS07065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K8O99_RS07110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K8O99_RS07130	COG0138	bifunctional purine biosynthesis protein purh
K8O99_RS07140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8O99_RS07140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K8O99_RS07145	COG0501	Belongs to the peptidase M48B family
K8O99_RS07155	COG0228	four-way junction DNA binding
K8O99_RS07165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K8O99_RS07170	COG0288	reversible hydration of carbon dioxide
K8O99_RS07175	COG2902	Dehydrogenase
K8O99_RS07200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K8O99_RS07215	COG0745	RESPONSE REGULATOR receiver
K8O99_RS07240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8O99_RS07245	COG1671	Belongs to the UPF0178 family
K8O99_RS07255	COG0287	Prephenate dehydrogenase
K8O99_RS07265	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K8O99_RS07290	COG0351	phosphomethylpyrimidine kinase
K8O99_RS07300	COG1686	Belongs to the peptidase S11 family
K8O99_RS07305	COG0523	cobalamin synthesis protein
K8O99_RS07310	COG3034	peptidoglycan biosynthetic process
K8O99_RS07315	COG0825	malonyl-CoA metabolic process
K8O99_RS07325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K8O99_RS07330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K8O99_RS07350	COG1320	monovalent cation:proton antiporter activity
K8O99_RS07355	COG2212	antiporter activity
K8O99_RS07360	COG1863	multisubunit Na H antiporter MnhE subunit
K8O99_RS07365	COG0651	ATP synthesis coupled electron transport
K8O99_RS07370	COG1006	Multisubunit Na H antiporter MnhC subunit
K8O99_RS07375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K8O99_RS07375	COG2111	Na H antiporter
K8O99_RS07385	COG0019	diaminopimelate decarboxylase activity
K8O99_RS07410	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8O99_RS07415	COG0567	Dehydrogenase, E1 component
K8O99_RS07425	COG0045	succinate-CoA ligase (ADP-forming) activity
K8O99_RS07430	COG0039	L-malate dehydrogenase activity
K8O99_RS07435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K8O99_RS07445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K8O99_RS07450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8O99_RS07455	COG0552	protein localization to endoplasmic reticulum
K8O99_RS07460	COG2917	probably involved in intracellular septation
K8O99_RS07465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8O99_RS07480	COG0357	Ribosomal RNA small subunit methyltransferase G
K8O99_RS07485	COG0445	tRNA wobble uridine modification
K8O99_RS07490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K8O99_RS07495	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K8O99_RS07500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K8O99_RS07505	COG0424	maF-like protein
K8O99_RS07510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K8O99_RS07515	COG0237	dephospho-CoA kinase activity
K8O99_RS07525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8O99_RS07525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8O99_RS07535	COG0670	Belongs to the BI1 family
K8O99_RS07545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K8O99_RS07555	COG0116	Belongs to the methyltransferase superfamily
K8O99_RS07555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K8O99_RS07565	COG0776	regulation of translation
K8O99_RS07580	COG1137	ATPase activity
K8O99_RS07590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O99_RS07600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K8O99_RS07605	COG1280	lysine exporter protein (LysE YggA)
K8O99_RS07625	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K8O99_RS07640	COG2887	Belongs to the helicase family. UvrD subfamily
K8O99_RS07650	COG2205	protein histidine kinase activity
K8O99_RS07655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K8O99_RS07665	COG0285	dihydrofolate synthase activity
K8O99_RS07670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K8O99_RS07680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K8O99_RS07685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K8O99_RS07690	COG2226	methyltransferase
K8O99_RS07705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8O99_RS07710	COG0606	chelatase, subunit chli
K8O99_RS07730	COG1132	(ABC) transporter
K8O99_RS07735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K8O99_RS07750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8O99_RS07755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8O99_RS07760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K8O99_RS07765	COG1420	regulation of RNA biosynthetic process
K8O99_RS07770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K8O99_RS07785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8O99_RS07785	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8O99_RS07795	COG2205	protein histidine kinase activity
K8O99_RS07800	COG0745	RESPONSE REGULATOR receiver
K8O99_RS07805	COG1652	LysM domain
K8O99_RS07815	COG0443	Heat shock 70 kDa protein
K8O99_RS07820	COG0484	heat shock protein binding
K8O99_RS07830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K8O99_RS07835	COG0697	spore germination
K8O99_RS07840	COG0481	GTPase activity
K8O99_RS07845	COG2171	N-acyltransferase activity
K8O99_RS07855	COG0101	tRNA pseudouridine synthase activity
K8O99_RS07860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K8O99_RS07865	COG0242	peptide deformylase activity
K8O99_RS07895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K8O99_RS07900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K8O99_RS07905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K8O99_RS07910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8O99_RS07910	COG0072	phenylalanine-tRNA ligase activity
K8O99_RS07920	COG1121	(ABC) transporter
K8O99_RS07925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K8O99_RS07930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K8O99_RS07935	COG2832	Protein of unknown function (DUF454)
K8O99_RS07940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K8O99_RS07945	COG3459	Glycosyltransferase 36 associated
K8O99_RS07950	COG0539	negative regulation of cytoplasmic translation
K8O99_RS07955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K8O99_RS07960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K8O99_RS07975	COG0129	dihydroxy-acid dehydratase activity
K8O99_RS07985	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K8O99_RS07990	COG0281	malic enzyme
K8O99_RS07990	COG0280	phosphate acetyltransferase
K8O99_RS07995	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K8O99_RS08000	COG3030	protein affecting phage T7 exclusion by the F plasmid
K8O99_RS08020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K8O99_RS08030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8O99_RS08040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8O99_RS08045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8O99_RS08050	COG4133	protoheme IX ABC transporter activity
K8O99_RS08055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K8O99_RS08060	COG0268	Binds directly to 16S ribosomal RNA
K8O99_RS08065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K8O99_RS08080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K8O99_RS08085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K8O99_RS08090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K8O99_RS08100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K8O99_RS08105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K8O99_RS08110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K8O99_RS08120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8O99_RS08135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K8O99_RS08160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8O99_RS08165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8O99_RS08170	COG0166	Belongs to the GPI family
K8O99_RS08180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K8O99_RS08185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K8O99_RS08195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K8O99_RS08195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system