locus-tag	class	description
KAE70_RS00005	COG0372	Belongs to the citrate synthase family
KAE70_RS00010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAE70_RS00020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KAE70_RS00035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KAE70_RS00045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAE70_RS00045	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
KAE70_RS00050	COG0513	Belongs to the DEAD box helicase family
KAE70_RS00065	COG2986	histidine ammonia-lyase
KAE70_RS00085	COG2831	hemolysin activation secretion protein
KAE70_RS00125	COG3842	ATPase activity
KAE70_RS00130	COG0784	Response regulator, receiver
KAE70_RS00135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KAE70_RS00140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KAE70_RS00145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KAE70_RS00150	COG0187	DNA topoisomerase II activity
KAE70_RS00155	COG0321	lipoyl(octanoyl) transferase activity
KAE70_RS00160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KAE70_RS00195	COG2831	hemolysin activation secretion protein
KAE70_RS00200	COG3210	domain, Protein
KAE70_RS00200	COG3210	domain, Protein
KAE70_RS00260	COG0071	Belongs to the small heat shock protein (HSP20) family
KAE70_RS00295	COG0316	Belongs to the HesB IscA family
KAE70_RS00300	COG3956	TIGRFAM MazG family protein
KAE70_RS00310	COG1063	alcohol dehydrogenase
KAE70_RS00315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAE70_RS00325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KAE70_RS00330	COG0280	phosphate acetyltransferase
KAE70_RS00330	COG0281	malic enzyme
KAE70_RS00340	COG1923	regulation of RNA biosynthetic process
KAE70_RS00345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KAE70_RS00355	COG1612	heme a metabolic process
KAE70_RS00365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KAE70_RS00370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KAE70_RS00375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAE70_RS00375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAE70_RS00385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KAE70_RS00390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAE70_RS00405	COG0416	fatty acid biosynthetic process
KAE70_RS00410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KAE70_RS00415	COG0776	regulation of translation
KAE70_RS00425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KAE70_RS00430	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KAE70_RS00440	COG0302	gtp cyclohydrolase
KAE70_RS00480	COG1598	PFAM Uncharacterised protein family UPF0150
KAE70_RS00505	COG0629	single-stranded DNA binding
KAE70_RS00690	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KAE70_RS00695	COG3657	addiction module killer protein
KAE70_RS00720	COG3561	AntA/AntB antirepressor
KAE70_RS00725	COG3077	Addiction module antitoxin, RelB DinJ family
KAE70_RS00730	COG3041	Addiction module toxin RelE StbE family
KAE70_RS00765	COG3657	addiction module killer protein
KAE70_RS00785	COG3561	AntA/AntB antirepressor
KAE70_RS00805	COG1598	PFAM Uncharacterised protein family UPF0150
KAE70_RS00815	COG0629	single-stranded DNA binding
KAE70_RS00825	COG1598	PFAM Uncharacterised protein family UPF0150
KAE70_RS01025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAE70_RS01030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAE70_RS01035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAE70_RS01040	COG0649	NAD binding
KAE70_RS01045	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KAE70_RS01050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KAE70_RS01060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KAE70_RS01065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAE70_RS01075	COG0713	ATP synthesis coupled electron transport
KAE70_RS01090	COG1007	ATP synthesis coupled electron transport
KAE70_RS01105	COG0442	prolyl-tRNA aminoacylation
KAE70_RS01115	COG1136	(ABC) transporter
KAE70_RS01120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KAE70_RS01125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KAE70_RS01140	COG1530	ribonuclease E activity
KAE70_RS01145	COG0860	N-Acetylmuramoyl-L-alanine amidase
KAE70_RS01150	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KAE70_RS01160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KAE70_RS01165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KAE70_RS01170	COG2945	thiolester hydrolase activity
KAE70_RS01180	COG0719	Fe-S assembly protein
KAE70_RS01185	COG0396	ATPase activity
KAE70_RS01190	COG0719	Fe-S assembly protein
KAE70_RS01195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KAE70_RS01225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAE70_RS01230	COG1183	phosphatidylcholine synthase activity
KAE70_RS01245	COG0321	lipoyl(octanoyl) transferase activity
KAE70_RS01245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KAE70_RS01250	COG0084	hydrolase, TatD family'
KAE70_RS01255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAE70_RS01265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KAE70_RS01270	COG1686	Belongs to the peptidase S11 family
KAE70_RS01285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KAE70_RS01290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAE70_RS01295	COG0037	tRNA processing
KAE70_RS01300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KAE70_RS01305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KAE70_RS01315	COG1489	DNA binding
KAE70_RS01320	COG0024	Methionine aminopeptidase
KAE70_RS01325	COG2003	Belongs to the UPF0758 family
KAE70_RS01335	COG0596	Alpha beta hydrolase
KAE70_RS01345	COG1278	Cold shock
KAE70_RS01375	COG0154	amidase activity
KAE70_RS01380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KAE70_RS01385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KAE70_RS01395	COG0540	Belongs to the ATCase OTCase family
KAE70_RS01400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KAE70_RS01405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KAE70_RS01410	COG0758	DNA mediated transformation
KAE70_RS01420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KAE70_RS01425	COG0557	exoribonuclease II activity
KAE70_RS01430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KAE70_RS01440	COG1573	uracil-dna glycosylase
KAE70_RS01445	COG1522	sequence-specific DNA binding
KAE70_RS01470	COG0511	ligase activity, forming carbon-carbon bonds
KAE70_RS01495	COG0582	viral genome integration into host DNA
KAE70_RS01530	COG0628	permease
KAE70_RS01535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KAE70_RS01540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KAE70_RS01575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KAE70_RS01585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KAE70_RS01595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KAE70_RS01600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KAE70_RS01605	COG0047	phosphoribosylformylglycinamidine synthase activity
KAE70_RS01610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KAE70_RS01620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KAE70_RS01625	COG2814	Major facilitator Superfamily
KAE70_RS01630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KAE70_RS01635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KAE70_RS01640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KAE70_RS01645	COG0248	Ppx GppA phosphatase
KAE70_RS01650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KAE70_RS01660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAE70_RS01670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KAE70_RS01685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KAE70_RS01690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KAE70_RS01695	COG0785	Cytochrome C biogenesis protein
KAE70_RS01705	COG0316	Belongs to the HesB IscA family
KAE70_RS01710	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KAE70_RS01715	COG0018	arginyl-trna synthetase
KAE70_RS01730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KAE70_RS01750	COG0538	isocitrate dehydrogenase activity
KAE70_RS01760	COG2814	Major facilitator Superfamily
KAE70_RS01765	COG0343	queuine tRNA-ribosyltransferase activity
KAE70_RS01780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KAE70_RS01785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KAE70_RS01790	COG0629	single-stranded DNA binding
KAE70_RS01800	COG0347	Belongs to the P(II) protein family
KAE70_RS01805	COG0174	glutamine synthetase
KAE70_RS01825	COG1132	(ABC) transporter
KAE70_RS01830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KAE70_RS01835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KAE70_RS01840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KAE70_RS01845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAE70_RS01850	COG0203	ribosomal protein L17
KAE70_RS01855	COG0202	RNA polymerase activity
KAE70_RS01860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KAE70_RS01865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KAE70_RS01870	COG0563	adenylate kinase activity
KAE70_RS01880	COG0200	Binds to the 23S rRNA
KAE70_RS01885	COG1841	ribosomal large subunit assembly
KAE70_RS01890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KAE70_RS01895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KAE70_RS01900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KAE70_RS01905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KAE70_RS01910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KAE70_RS01915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KAE70_RS01920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KAE70_RS01925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KAE70_RS01930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KAE70_RS01935	COG0255	Belongs to the universal ribosomal protein uL29 family
KAE70_RS01940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KAE70_RS01945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KAE70_RS01950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KAE70_RS01955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KAE70_RS01960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KAE70_RS01965	COG0089	rRNA binding
KAE70_RS01970	COG0088	Forms part of the polypeptide exit tunnel
KAE70_RS01975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KAE70_RS01980	COG0051	transcription antitermination factor activity, RNA binding
KAE70_RS01985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAE70_RS01990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KAE70_RS01995	COG0049	tRNA binding
KAE70_RS02000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KAE70_RS02015	COG0765	amino acid transport
KAE70_RS02020	COG0765	amino acid transport
KAE70_RS02025	COG1126	abc transporter atp-binding protein
KAE70_RS02035	COG0525	valine-tRNA ligase activity
KAE70_RS02050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KAE70_RS02095	COG0513	Belongs to the DEAD box helicase family
KAE70_RS02100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KAE70_RS02110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE70_RS02120	COG3264	Mechanosensitive ion channel
KAE70_RS02120	COG1196	nuclear chromosome segregation
KAE70_RS02135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KAE70_RS02135	COG4651	solute:proton antiporter activity
KAE70_RS02145	COG1253	flavin adenine dinucleotide binding
KAE70_RS02155	COG1113	amino acid transport
KAE70_RS02160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KAE70_RS02170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KAE70_RS02175	COG0028	Belongs to the TPP enzyme family
KAE70_RS02180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KAE70_RS02190	COG0330	HflC and HflK could
KAE70_RS02200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KAE70_RS02205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KAE70_RS02210	COG0477	Major facilitator Superfamily
KAE70_RS02215	COG0477	Major facilitator Superfamily
KAE70_RS02220	COG0477	Major facilitator Superfamily
KAE70_RS02250	COG0210	DNA helicase
KAE70_RS02260	COG1999	signal sequence binding
KAE70_RS02270	COG0006	proline dipeptidase activity
KAE70_RS02275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KAE70_RS02280	COG0497	DNA recombination
KAE70_RS02285	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAE70_RS02300	COG0849	cell division
KAE70_RS02310	COG1181	Belongs to the D-alanine--D-alanine ligase family
KAE70_RS02315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KAE70_RS02320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KAE70_RS02325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KAE70_RS02335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KAE70_RS02340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KAE70_RS02350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KAE70_RS02365	COG0275	rRNA processing
KAE70_RS02375	COG0741	lytic transglycosylase activity
KAE70_RS02385	COG2226	methyltransferase
KAE70_RS02400	COG1335	isochorismatase
KAE70_RS02445	COG2968	Membrane
KAE70_RS02450	COG2983	Belongs to the UPF0260 family
KAE70_RS02455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAE70_RS02465	COG0668	transmembrane transport
KAE70_RS02480	COG3161	chorismate lyase activity
KAE70_RS02485	COG0505	Belongs to the CarA family
KAE70_RS02505	COG1278	Cold shock
KAE70_RS02510	COG0436	Aminotransferase
KAE70_RS02515	COG0583	DNA-binding transcription factor activity
KAE70_RS02520	COG0492	ferredoxin-NADP+ reductase activity
KAE70_RS02525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAE70_RS02540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KAE70_RS02550	COG0556	nucleotide-excision repair
KAE70_RS02560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAE70_RS02565	COG0745	RESPONSE REGULATOR receiver
KAE70_RS02570	COG2205	protein histidine kinase activity
KAE70_RS02585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KAE70_RS02595	COG1496	oxidoreductase activity
KAE70_RS02610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KAE70_RS02615	COG0193	aminoacyl-tRNA hydrolase activity
KAE70_RS02620	COG1376	ErfK ybiS ycfS ynhG family protein
KAE70_RS02625	COG0012	GTP binding
KAE70_RS02645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KAE70_RS02655	COG0714	Associated with various cellular activities
KAE70_RS02680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KAE70_RS02685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAE70_RS02690	COG0482	sulfurtransferase activity
KAE70_RS02770	COG0444	Belongs to the ABC transporter superfamily
KAE70_RS02775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAE70_RS02780	COG0601	transmembrane transport
KAE70_RS02785	COG0747	negative chemotaxis
KAE70_RS02795	COG0519	Catalyzes the synthesis of GMP from XMP
KAE70_RS02800	COG1570	exodeoxyribonuclease VII activity
KAE70_RS02805	COG0747	negative chemotaxis
KAE70_RS02825	COG0730	response to heat
KAE70_RS02835	COG2086	electron transfer activity
KAE70_RS02865	COG0792	nuclease activity
KAE70_RS02870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KAE70_RS02875	COG0489	protein tyrosine kinase activity
KAE70_RS02880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KAE70_RS02885	COG0594	ribonuclease P activity
KAE70_RS02895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KAE70_RS02905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KAE70_RS02910	COG0588	phosphoglycerate mutase activity
KAE70_RS02920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KAE70_RS02940	COG3023	N-Acetylmuramoyl-L-alanine amidase
KAE70_RS02950	COG1546	Belongs to the CinA family
KAE70_RS02950	COG1058	Belongs to the CinA family
KAE70_RS02955	COG0473	3-isopropylmalate dehydrogenase activity
KAE70_RS02955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KAE70_RS02970	COG2814	Major facilitator Superfamily
KAE70_RS03030	COG0735	belongs to the Fur family
KAE70_RS03060	COG1054	Belongs to the UPF0176 family
KAE70_RS03065	COG0800	Aldolase
KAE70_RS03110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAE70_RS03110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAE70_RS03115	COG0509	glycine decarboxylation via glycine cleavage system
KAE70_RS03120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KAE70_RS03130	COG2835	tetraacyldisaccharide 4'-kinase activity
KAE70_RS03135	COG1396	sequence-specific DNA binding
KAE70_RS03140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KAE70_RS03155	COG1464	Belongs to the NlpA lipoprotein family
KAE70_RS03160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KAE70_RS03165	COG2011	ABC-type metal ion transport system permease component
KAE70_RS03190	COG0523	cobalamin synthesis protein
KAE70_RS03355	COG1192	Involved in chromosome partitioning
KAE70_RS03365	COG0196	riboflavin kinase activity
KAE70_RS03390	COG3838	Conjugal transfer protein Trbc
KAE70_RS03395	COG3702	type iv secretory pathway
KAE70_RS03400	COG3451	type IV secretory pathway VirB4
KAE70_RS03410	COG3704	protein secretion by the type IV secretion system
KAE70_RS03420	COG3736	Type IV secretory pathway, component VirB8
KAE70_RS03425	COG3504	Conjugal transfer protein
KAE70_RS03430	COG2948	multi-organism process
KAE70_RS03435	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
KAE70_RS03445	COG2184	nucleotidyltransferase activity
KAE70_RS03450	COG3505	Type IV secretory pathway VirD4
KAE70_RS03455	COG2184	nucleotidyltransferase activity
KAE70_RS03465	COG2184	nucleotidyltransferase activity
KAE70_RS03500	COG0728	peptidoglycan biosynthetic process
KAE70_RS03505	COG0180	Tryptophanyl-tRNA synthetase
KAE70_RS03515	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KAE70_RS03520	COG2824	Alkylphosphonate utilization operon protein PhnA
KAE70_RS03525	COG0459	protein refolding
KAE70_RS03530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KAE70_RS03545	COG1396	sequence-specific DNA binding
KAE70_RS03550	COG0033	Phosphoglucomutase
KAE70_RS03565	COG1396	sequence-specific DNA binding
KAE70_RS03575	COG0124	histidyl-tRNA synthetase
KAE70_RS03585	COG0284	orotidine-5'-phosphate decarboxylase activity
KAE70_RS03640	COG0739	heme binding
KAE70_RS03645	COG3920	Histidine kinase
KAE70_RS03660	COG0784	Response regulator, receiver
KAE70_RS03790	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KAE70_RS03795	COG0424	maF-like protein
KAE70_RS03800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KAE70_RS03810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KAE70_RS03880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KAE70_RS03890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KAE70_RS03895	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KAE70_RS03900	COG0457	Tetratricopeptide repeat
KAE70_RS03920	COG1396	sequence-specific DNA binding
KAE70_RS03940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KAE70_RS04095	COG0756	dUTP diphosphatase activity
KAE70_RS04105	COG0848	biopolymer transport protein
KAE70_RS04110	COG0811	peptide transport
KAE70_RS04130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KAE70_RS04135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KAE70_RS04140	COG0037	tRNA processing
KAE70_RS04150	COG2885	chlorophyll binding
KAE70_RS04160	COG0217	transcriptional regulatory protein
KAE70_RS04170	COG0823	Involved in the tonB-independent uptake of proteins
KAE70_RS04190	COG0824	Thioesterase
KAE70_RS04200	COG2255	four-way junction helicase activity
KAE70_RS04205	COG0632	four-way junction helicase activity
KAE70_RS04210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KAE70_RS04225	COG0352	thiamine-phosphate diphosphorylase activity
KAE70_RS04235	COG1396	sequence-specific DNA binding
KAE70_RS04255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KAE70_RS04260	COG0483	inositol monophosphate 1-phosphatase activity
KAE70_RS04265	COG1132	(ABC) transporter
KAE70_RS04270	COG0254	rRNA binding
KAE70_RS04280	COG3588	fructose-bisphosphate aldolase
KAE70_RS04285	COG0126	phosphoglycerate kinase activity
KAE70_RS04315	COG0469	pyruvate kinase activity
KAE70_RS04325	COG3750	Belongs to the UPF0335 family
KAE70_RS04340	COG0488	(ABC) transporter
KAE70_RS04360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAE70_RS04370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KAE70_RS04380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KAE70_RS04385	COG0142	geranyltranstransferase activity
KAE70_RS04420	COG0542	response to heat
KAE70_RS04425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KAE70_RS04435	COG1566	PFAM secretion protein HlyD family protein
KAE70_RS04445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KAE70_RS04450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KAE70_RS04455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KAE70_RS04460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KAE70_RS04465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KAE70_RS04475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KAE70_RS04490	COG0495	leucyl-tRNA aminoacylation
KAE70_RS04505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KAE70_RS04510	COG2884	Cell division ATP-binding protein ftsE
KAE70_RS04530	COG1136	(ABC) transporter
KAE70_RS04530	COG0577	efflux transmembrane transporter activity
KAE70_RS04535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAE70_RS04540	COG1538	Outer membrane efflux protein
KAE70_RS04555	COG1674	ftsk spoiiie
KAE70_RS04560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAE70_RS04705	COG3504	Conjugal transfer protein
KAE70_RS04745	COG0335	large ribosomal subunit rRNA binding
KAE70_RS04750	COG0336	Belongs to the RNA methyltransferase TrmD family
KAE70_RS04755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KAE70_RS04800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KAE70_RS04815	COG0138	bifunctional purine biosynthesis protein purh
KAE70_RS04825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KAE70_RS04825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAE70_RS04830	COG0501	Belongs to the peptidase M48B family
KAE70_RS04840	COG0228	four-way junction DNA binding
KAE70_RS04850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KAE70_RS04855	COG0288	reversible hydration of carbon dioxide
KAE70_RS04860	COG2902	Dehydrogenase
KAE70_RS04885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KAE70_RS04900	COG0745	RESPONSE REGULATOR receiver
KAE70_RS04925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAE70_RS04930	COG1671	Belongs to the UPF0178 family
KAE70_RS04940	COG0287	Prephenate dehydrogenase
KAE70_RS04950	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KAE70_RS04980	COG0351	phosphomethylpyrimidine kinase
KAE70_RS04990	COG1686	Belongs to the peptidase S11 family
KAE70_RS04995	COG0523	cobalamin synthesis protein
KAE70_RS05000	COG3034	peptidoglycan biosynthetic process
KAE70_RS05005	COG0825	malonyl-CoA metabolic process
KAE70_RS05020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KAE70_RS05040	COG1320	monovalent cation:proton antiporter activity
KAE70_RS05045	COG2212	antiporter activity
KAE70_RS05050	COG1863	multisubunit Na H antiporter MnhE subunit
KAE70_RS05055	COG0651	ATP synthesis coupled electron transport
KAE70_RS05060	COG1006	Multisubunit Na H antiporter MnhC subunit
KAE70_RS05065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KAE70_RS05065	COG2111	Na H antiporter
KAE70_RS05075	COG0019	diaminopimelate decarboxylase activity
KAE70_RS05090	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAE70_RS05095	COG0567	Dehydrogenase, E1 component
KAE70_RS05105	COG0045	succinate-CoA ligase (ADP-forming) activity
KAE70_RS05110	COG0039	L-malate dehydrogenase activity
KAE70_RS05115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KAE70_RS05125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KAE70_RS05130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAE70_RS05135	COG0552	protein localization to endoplasmic reticulum
KAE70_RS05140	COG2917	probably involved in intracellular septation
KAE70_RS05145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAE70_RS05160	COG0357	Ribosomal RNA small subunit methyltransferase G
KAE70_RS05165	COG0445	tRNA wobble uridine modification
KAE70_RS05170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KAE70_RS05175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KAE70_RS05180	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KAE70_RS05185	COG0424	maF-like protein
KAE70_RS05190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KAE70_RS05195	COG0237	dephospho-CoA kinase activity
KAE70_RS05205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAE70_RS05205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAE70_RS05215	COG0670	Belongs to the BI1 family
KAE70_RS05225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KAE70_RS05235	COG0116	Belongs to the methyltransferase superfamily
KAE70_RS05235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KAE70_RS05245	COG0776	regulation of translation
KAE70_RS05260	COG1137	ATPase activity
KAE70_RS05265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAE70_RS05275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KAE70_RS05280	COG1280	lysine exporter protein (LysE YggA)
KAE70_RS05295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KAE70_RS05310	COG2887	Belongs to the helicase family. UvrD subfamily
KAE70_RS05320	COG2205	protein histidine kinase activity
KAE70_RS05325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KAE70_RS05335	COG0285	dihydrofolate synthase activity
KAE70_RS05340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KAE70_RS05355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KAE70_RS05360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KAE70_RS05365	COG2226	methyltransferase
KAE70_RS05375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAE70_RS05380	COG0606	chelatase, subunit chli
KAE70_RS05395	COG1132	(ABC) transporter
KAE70_RS05400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KAE70_RS05415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KAE70_RS05420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KAE70_RS05425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KAE70_RS05430	COG1420	regulation of RNA biosynthetic process
KAE70_RS05435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KAE70_RS05450	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAE70_RS05450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAE70_RS05460	COG2205	protein histidine kinase activity
KAE70_RS05465	COG0745	RESPONSE REGULATOR receiver
KAE70_RS05470	COG1652	LysM domain
KAE70_RS05480	COG0443	Heat shock 70 kDa protein
KAE70_RS05485	COG0484	heat shock protein binding
KAE70_RS05495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KAE70_RS05500	COG0697	spore germination
KAE70_RS05505	COG0481	GTPase activity
KAE70_RS05510	COG2171	N-acyltransferase activity
KAE70_RS05520	COG0101	tRNA pseudouridine synthase activity
KAE70_RS05525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KAE70_RS05530	COG0242	peptide deformylase activity
KAE70_RS05560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KAE70_RS05565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KAE70_RS05570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KAE70_RS05575	COG0072	phenylalanine-tRNA ligase activity
KAE70_RS05575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAE70_RS05585	COG1121	(ABC) transporter
KAE70_RS05590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KAE70_RS05595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KAE70_RS05600	COG2832	Protein of unknown function (DUF454)
KAE70_RS05605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KAE70_RS05610	COG3459	Glycosyltransferase 36 associated
KAE70_RS05615	COG0539	negative regulation of cytoplasmic translation
KAE70_RS05620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KAE70_RS05625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KAE70_RS05640	COG0129	dihydroxy-acid dehydratase activity
KAE70_RS05645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KAE70_RS05650	COG0280	phosphate acetyltransferase
KAE70_RS05650	COG0281	malic enzyme
KAE70_RS05655	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KAE70_RS05660	COG3030	protein affecting phage T7 exclusion by the F plasmid
KAE70_RS05680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KAE70_RS05690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAE70_RS05700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAE70_RS05705	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAE70_RS05710	COG4133	protoheme IX ABC transporter activity
KAE70_RS05715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KAE70_RS05720	COG0268	Binds directly to 16S ribosomal RNA
KAE70_RS05725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KAE70_RS05740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KAE70_RS05745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KAE70_RS05750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KAE70_RS05755	COG1845	cytochrome c oxidase, subunit III
KAE70_RS05760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KAE70_RS05765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KAE70_RS05770	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAE70_RS05780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAE70_RS05795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KAE70_RS05820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAE70_RS05825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAE70_RS05830	COG0166	Belongs to the GPI family
KAE70_RS05840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KAE70_RS05845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KAE70_RS05850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAE70_RS05850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KAE70_RS05935	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KAE70_RS05940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KAE70_RS05945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KAE70_RS05950	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KAE70_RS05955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KAE70_RS05960	COG0799	negative regulation of ribosome biogenesis
KAE70_RS05965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KAE70_RS05975	COG0793	Belongs to the peptidase S41A family
KAE70_RS05980	COG0494	nUDIX hydrolase
KAE70_RS05985	COG5342	invasion associated locus B
KAE70_RS05995	COG1872	DUF167
KAE70_RS06000	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KAE70_RS06005	COG1217	gtp-binding protein TYPA
KAE70_RS06010	COG2239	Acts as a magnesium transporter
KAE70_RS06015	COG0339	signal peptide processing
KAE70_RS06025	COG2951	lytic endotransglycosylase activity
KAE70_RS06030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KAE70_RS06035	COG0517	IMP dehydrogenase activity
KAE70_RS06035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KAE70_RS06050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KAE70_RS06070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KAE70_RS06070	COG0519	Catalyzes the synthesis of GMP from XMP
KAE70_RS06075	COG0584	glycerophosphoryl diester phosphodiesterase
KAE70_RS06080	COG3842	ATPase activity
KAE70_RS06085	COG0395	ABC-type sugar transport system, permease component
KAE70_RS06090	COG1175	transmembrane transport
KAE70_RS06100	COG0803	Belongs to the bacterial solute-binding protein 9 family
KAE70_RS06105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KAE70_RS06110	COG1121	(ABC) transporter
KAE70_RS06120	COG1780	Probably involved in ribonucleotide reductase function
KAE70_RS06125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAE70_RS06135	COG2890	protein-(glutamine-N5) methyltransferase activity
KAE70_RS06140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KAE70_RS06150	COG0653	protein targeting
KAE70_RS06155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KAE70_RS06160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KAE70_RS06165	COG0494	nUDIX hydrolase
KAE70_RS06180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KAE70_RS06185	COG1072	(Pantothenic acid kinase))
KAE70_RS06190	COG0252	asparaginase activity
KAE70_RS06195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KAE70_RS06200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KAE70_RS06205	COG2813	Specifically methylates the guanine in position
KAE70_RS06210	COG1185	polyribonucleotide nucleotidyltransferase activity
KAE70_RS06215	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KAE70_RS06225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KAE70_RS06230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KAE70_RS06235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KAE70_RS06245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KAE70_RS06245	COG0195	Participates in both transcription termination and antitermination
KAE70_RS06250	COG0779	Required for maturation of 30S ribosomal subunits
KAE70_RS06255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KAE70_RS06260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KAE70_RS06265	COG1396	sequence-specific DNA binding
KAE70_RS06270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KAE70_RS06280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KAE70_RS06285	COG1702	phosphate starvation-inducible protein PhoH
KAE70_RS06290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAE70_RS06300	COG1214	PFAM Peptidase M22, glycoprotease
KAE70_RS06305	COG2855	membrane
KAE70_RS06310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KAE70_RS06315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KAE70_RS06320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KAE70_RS06335	COG0077	Prephenate dehydratase
KAE70_RS06335	COG1605	Chorismate mutase
KAE70_RS06340	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KAE70_RS06345	COG3474	cytochrome
KAE70_RS06350	COG4174	ABC transporter (Permease)
KAE70_RS06355	COG4239	(ABC) transporter, permease
KAE70_RS06360	COG4172	Belongs to the ABC transporter superfamily
KAE70_RS06375	COG0189	ligase activity
KAE70_RS06385	COG0573	inorganic phosphate transmembrane transporter activity
KAE70_RS06395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KAE70_RS06400	COG0704	Plays a role in the regulation of phosphate uptake
KAE70_RS06420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KAE70_RS06440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE70_RS06445	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE70_RS06450	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE70_RS06455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KAE70_RS06465	COG0590	tRNA wobble adenosine to inosine editing
KAE70_RS06470	COG1187	pseudouridine synthase activity
KAE70_RS06475	COG0742	ribosomal rna small subunit methyltransferase
KAE70_RS06480	COG0312	modulator of DNA gyrase
KAE70_RS06485	COG0483	inositol monophosphate 1-phosphatase activity
KAE70_RS06495	COG1519	Transferase
KAE70_RS06500	COG1663	tetraacyldisaccharide 4'-kinase activity
KAE70_RS06510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KAE70_RS06515	COG0717	Belongs to the dCTP deaminase family
KAE70_RS06520	COG1304	FMN binding
KAE70_RS06540	COG1113	amino acid transport
KAE70_RS06545	COG1122	ATPase activity
KAE70_RS06555	COG1268	BioY protein
KAE70_RS06590	COG0582	viral genome integration into host DNA
KAE70_RS06595	COG3561	AntA/AntB antirepressor
KAE70_RS06600	COG3561	AntA/AntB antirepressor
KAE70_RS06605	COG3077	Addiction module antitoxin, RelB DinJ family
KAE70_RS06610	COG3041	Addiction module toxin RelE StbE family
KAE70_RS06655	COG3561	AntA/AntB antirepressor
KAE70_RS06785	COG3646	Phage regulatory protein
KAE70_RS06795	COG3646	Phage regulatory protein
KAE70_RS06865	COG3077	Addiction module antitoxin, RelB DinJ family
KAE70_RS06870	COG3041	Addiction module toxin RelE StbE family
KAE70_RS06880	COG3561	AntA/AntB antirepressor
KAE70_RS06895	COG3561	AntA/AntB antirepressor
KAE70_RS06925	COG0629	single-stranded DNA binding
KAE70_RS06935	COG3093	addiction module antidote protein HigA
KAE70_RS07000	COG3561	AntA/AntB antirepressor
KAE70_RS07010	COG3561	AntA/AntB antirepressor
KAE70_RS07040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KAE70_RS07050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAE70_RS07055	COG0564	pseudouridine synthase activity
KAE70_RS07080	COG1970	mechanosensitive ion channel activity
KAE70_RS07085	COG0167	dihydroorotate dehydrogenase activity
KAE70_RS07100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAE70_RS07105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KAE70_RS07110	COG0363	glucosamine-6-phosphate deaminase activity
KAE70_RS07115	COG0129	dihydroxy-acid dehydratase activity
KAE70_RS07120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KAE70_RS07145	COG1823	symporter activity
KAE70_RS07150	COG2226	methyltransferase
KAE70_RS07155	COG1040	competence protein
KAE70_RS07160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KAE70_RS07165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAE70_RS07170	COG0527	aspartate kinase activity
KAE70_RS07175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAE70_RS07185	COG3273	potassium ion transport
KAE70_RS07185	COG0471	metal ion transport
KAE70_RS07195	COG1160	GTP binding
KAE70_RS07210	COG0356	it plays a direct role in the translocation of protons across the membrane
KAE70_RS07220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KAE70_RS07225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KAE70_RS07230	COG0751	glycine-tRNA ligase activity
KAE70_RS07245	COG0142	geranyltranstransferase activity
KAE70_RS07260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KAE70_RS07270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KAE70_RS07275	COG0009	L-threonylcarbamoyladenylate synthase
KAE70_RS07280	COG0277	FAD linked oxidase domain protein
KAE70_RS07295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KAE70_RS07300	COG0259	pyridoxamine-phosphate oxidase activity
KAE70_RS07305	COG0484	heat shock protein binding
KAE70_RS07310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAE70_RS07315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KAE70_RS07320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KAE70_RS07320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KAE70_RS07325	COG1722	exodeoxyribonuclease VII activity
KAE70_RS07330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KAE70_RS07345	COG0312	modulator of DNA gyrase
KAE70_RS07355	COG0109	protoheme IX farnesyltransferase activity
KAE70_RS07360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KAE70_RS07365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KAE70_RS07370	COG0328	RNA-DNA hybrid ribonuclease activity
KAE70_RS07380	COG1678	Uncharacterized ACR, COG1678
KAE70_RS07390	COG0612	Peptidase, M16
KAE70_RS07420	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KAE70_RS07425	COG1194	a g-specific adenine glycosylase
KAE70_RS07435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KAE70_RS07435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAE70_RS07440	COG0574	Belongs to the PEP-utilizing enzyme family
KAE70_RS07440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KAE70_RS07455	COG2166	iron-sulfur cluster assembly
KAE70_RS07470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KAE70_RS07495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KAE70_RS07520	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KAE70_RS07525	COG1138	Cytochrome C-type biogenesis protein
KAE70_RS07530	COG3088	subunit of a heme lyase
KAE70_RS07535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAE70_RS07540	COG0745	RESPONSE REGULATOR receiver
KAE70_RS07545	COG0642	Histidine kinase
KAE70_RS07555	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE70_RS07565	COG2205	protein histidine kinase activity
KAE70_RS07565	COG2202	Pas domain
KAE70_RS07570	COG0308	aminopeptidase N
KAE70_RS07580	COG0351	phosphomethylpyrimidine kinase
KAE70_RS07590	COG2022	thiamine diphosphate biosynthetic process
KAE70_RS07605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KAE70_RS07615	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KAE70_RS07620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAE70_RS07625	COG4558	Periplasmic binding protein
KAE70_RS07630	COG3720	iron ion transport
KAE70_RS07635	COG4771	TonB-dependent receptor
KAE70_RS07645	COG0741	lytic transglycosylase activity
KAE70_RS07650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KAE70_RS07655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KAE70_RS07660	COG1573	uracil-dna glycosylase
KAE70_RS07665	COG1758	RNA polymerase activity
KAE70_RS07675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KAE70_RS07685	COG0736	holo-[acyl-carrier-protein] synthase activity
KAE70_RS07695	COG0571	ribonuclease III activity
KAE70_RS07705	COG1381	Involved in DNA repair and RecF pathway recombination
KAE70_RS07710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KAE70_RS07715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KAE70_RS07720	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
KAE70_RS07725	COG0354	folic acid binding
KAE70_RS07730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KAE70_RS07740	COG0215	cysteine-tRNA ligase activity
KAE70_RS07745	COG2323	membrane
KAE70_RS07750	COG5265	(ABC) transporter
KAE70_RS07755	COG0688	phosphatidylethanolamine metabolic process
KAE70_RS07760	COG1183	phosphatidylcholine synthase activity
KAE70_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
KAE70_RS07770	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KAE70_RS07785	COG0305	Participates in initiation and elongation during chromosome replication
KAE70_RS07790	COG0359	binds to the 23S rRNA
KAE70_RS07800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KAE70_RS07805	COG0360	Binds together with S18 to 16S ribosomal RNA
KAE70_RS07810	COG0671	phosphoesterase, PA-phosphatase related
KAE70_RS07815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KAE70_RS07825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KAE70_RS07830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAE70_RS07835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KAE70_RS07840	COG0194	GDP metabolic process
KAE70_RS07845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KAE70_RS07850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KAE70_RS07860	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KAE70_RS07890	COG0477	Major facilitator Superfamily
KAE70_RS07930	COG0105	UTP biosynthetic process
KAE70_RS07935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KAE70_RS07940	COG0322	excinuclease ABC activity
KAE70_RS07945	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KAE70_RS07965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAE70_RS07970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAE70_RS07975	COG0805	protein transport
KAE70_RS07980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KAE70_RS07985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KAE70_RS07990	COG1388	LysM domain
KAE70_RS07990	COG4942	peptidase
KAE70_RS07995	COG1862	Preprotein translocase
KAE70_RS08015	COG0149	triose-phosphate isomerase activity
KAE70_RS08025	COG0504	CTP synthase activity
KAE70_RS08030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KAE70_RS08035	COG0148	phosphopyruvate hydratase activity
KAE70_RS08055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KAE70_RS08060	COG0022	dehydrogenase e1 component
KAE70_RS08060	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAE70_RS08065	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAE70_RS08070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAE70_RS08075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KAE70_RS08080	COG2867	negative regulation of translational initiation
KAE70_RS08085	COG1058	Belongs to the CinA family
KAE70_RS08085	COG1546	Belongs to the CinA family
KAE70_RS08090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KAE70_RS08090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KAE70_RS08095	COG1959	2 iron, 2 sulfur cluster binding
KAE70_RS08100	COG5000	phosphorelay sensor kinase activity
KAE70_RS08105	COG2204	response regulator
KAE70_RS08110	COG0569	domain protein
KAE70_RS08120	COG0740	serine-type endopeptidase activity
KAE70_RS08125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KAE70_RS08140	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KAE70_RS08150	COG0544	peptidyl-prolyl cis-trans isomerase activity
KAE70_RS08155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KAE70_RS08165	COG4765	Protein conserved in bacteria
KAE70_RS08175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAE70_RS08190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAE70_RS08200	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KAE70_RS08210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KAE70_RS08215	COG0081	regulation of translation
KAE70_RS08220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KAE70_RS08225	COG0222	ribosome binding
KAE70_RS08230	COG0085	RNA polymerase activity
KAE70_RS08235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KAE70_RS08240	COG0789	Transcriptional regulator
KAE70_RS08250	COG1760	l-serine dehydratase
KAE70_RS08260	COG1686	Belongs to the peptidase S11 family
KAE70_RS08265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KAE70_RS08290	COG0052	Belongs to the universal ribosomal protein uS2 family
KAE70_RS08295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KAE70_RS08300	COG0528	UMP kinase activity
KAE70_RS08305	COG0233	cytoplasmic translational termination
KAE70_RS08315	COG0750	zinc metalloprotease
KAE70_RS08325	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAE70_RS08330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAE70_RS08335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAE70_RS08340	COG3494	Protein of unknown function (DUF1009)
KAE70_RS08345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAE70_RS08350	COG1126	abc transporter atp-binding protein
KAE70_RS08360	COG4215	(ABC) transporter