locus-tag	class	description
KAE73_RS00005	COG0372	Belongs to the citrate synthase family
KAE73_RS00010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAE73_RS00020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KAE73_RS00035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KAE73_RS00045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KAE73_RS00045	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
KAE73_RS00050	COG0513	Belongs to the DEAD box helicase family
KAE73_RS00065	COG2986	histidine ammonia-lyase
KAE73_RS00085	COG2831	hemolysin activation secretion protein
KAE73_RS00090	COG3210	domain, Protein
KAE73_RS00090	COG3210	domain, Protein
KAE73_RS00165	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KAE73_RS00170	COG3657	addiction module killer protein
KAE73_RS00185	COG0582	viral genome integration into host DNA
KAE73_RS00195	COG3561	AntA/AntB antirepressor
KAE73_RS00200	COG3077	Addiction module antitoxin, RelB DinJ family
KAE73_RS00230	COG3657	addiction module killer protein
KAE73_RS00245	COG3561	AntA/AntB antirepressor
KAE73_RS00255	COG0629	single-stranded DNA binding
KAE73_RS00350	COG0511	ligase activity, forming carbon-carbon bonds
KAE73_RS00375	COG1522	sequence-specific DNA binding
KAE73_RS00380	COG1573	uracil-dna glycosylase
KAE73_RS00390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KAE73_RS00395	COG0557	exoribonuclease II activity
KAE73_RS00400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KAE73_RS00410	COG0758	DNA mediated transformation
KAE73_RS00415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KAE73_RS00420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KAE73_RS00425	COG0540	Belongs to the ATCase OTCase family
KAE73_RS00435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KAE73_RS00440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KAE73_RS00445	COG0154	amidase activity
KAE73_RS00475	COG1278	Cold shock
KAE73_RS00485	COG0596	Alpha beta hydrolase
KAE73_RS00495	COG2003	Belongs to the UPF0758 family
KAE73_RS00500	COG0024	Methionine aminopeptidase
KAE73_RS00505	COG1489	DNA binding
KAE73_RS00515	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KAE73_RS00520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KAE73_RS00525	COG0037	tRNA processing
KAE73_RS00530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAE73_RS00550	COG1686	Belongs to the peptidase S11 family
KAE73_RS00555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KAE73_RS00565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAE73_RS00570	COG0084	hydrolase, TatD family'
KAE73_RS00575	COG0321	lipoyl(octanoyl) transferase activity
KAE73_RS00575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KAE73_RS00590	COG1183	phosphatidylcholine synthase activity
KAE73_RS00595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAE73_RS00610	COG2032	superoxide dismutase activity
KAE73_RS00625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KAE73_RS00630	COG0719	Fe-S assembly protein
KAE73_RS00635	COG0396	ATPase activity
KAE73_RS00640	COG0719	Fe-S assembly protein
KAE73_RS00650	COG2945	thiolester hydrolase activity
KAE73_RS00655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KAE73_RS00660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KAE73_RS00670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KAE73_RS00675	COG0860	N-Acetylmuramoyl-L-alanine amidase
KAE73_RS00680	COG1530	ribonuclease E activity
KAE73_RS00690	COG4166	transmembrane transport
KAE73_RS00695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KAE73_RS00700	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KAE73_RS00705	COG1136	(ABC) transporter
KAE73_RS00715	COG0442	prolyl-tRNA aminoacylation
KAE73_RS00730	COG1007	ATP synthesis coupled electron transport
KAE73_RS00745	COG0713	ATP synthesis coupled electron transport
KAE73_RS00755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAE73_RS00760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KAE73_RS00770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KAE73_RS00775	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KAE73_RS00780	COG0649	NAD binding
KAE73_RS00785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAE73_RS00790	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAE73_RS00795	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KAE73_RS00880	COG0629	single-stranded DNA binding
KAE73_RS00905	COG1598	PFAM Uncharacterised protein family UPF0150
KAE73_RS00945	COG0302	gtp cyclohydrolase
KAE73_RS00955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KAE73_RS00960	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KAE73_RS00970	COG0776	regulation of translation
KAE73_RS00975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KAE73_RS00980	COG0416	fatty acid biosynthetic process
KAE73_RS00995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAE73_RS01000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KAE73_RS01010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAE73_RS01010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KAE73_RS01015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KAE73_RS01020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KAE73_RS01030	COG1612	heme a metabolic process
KAE73_RS01040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KAE73_RS01055	COG0280	phosphate acetyltransferase
KAE73_RS01055	COG0281	malic enzyme
KAE73_RS01060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KAE73_RS01070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAE73_RS01075	COG1063	alcohol dehydrogenase
KAE73_RS01085	COG3956	TIGRFAM MazG family protein
KAE73_RS01090	COG0316	Belongs to the HesB IscA family
KAE73_RS01120	COG0071	Belongs to the small heat shock protein (HSP20) family
KAE73_RS01160	COG3210	domain, Protein
KAE73_RS01160	COG3210	domain, Protein
KAE73_RS01165	COG2831	hemolysin activation secretion protein
KAE73_RS01195	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KAE73_RS01200	COG0321	lipoyl(octanoyl) transferase activity
KAE73_RS01205	COG0187	DNA topoisomerase II activity
KAE73_RS01210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KAE73_RS01215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KAE73_RS01220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KAE73_RS01225	COG0784	Response regulator, receiver
KAE73_RS01295	COG0629	single-stranded DNA binding
KAE73_RS01320	COG3093	addiction module antidote protein HigA
KAE73_RS01390	COG0582	viral genome integration into host DNA
KAE73_RS01425	COG0628	permease
KAE73_RS01430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KAE73_RS01435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KAE73_RS01470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KAE73_RS01480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KAE73_RS01490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KAE73_RS01495	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KAE73_RS01500	COG0047	phosphoribosylformylglycinamidine synthase activity
KAE73_RS01505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KAE73_RS01515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KAE73_RS01520	COG2814	Major facilitator Superfamily
KAE73_RS01525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KAE73_RS01530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KAE73_RS01535	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KAE73_RS01540	COG0248	Ppx GppA phosphatase
KAE73_RS01545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KAE73_RS01555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAE73_RS01565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KAE73_RS01580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KAE73_RS01585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KAE73_RS01590	COG0785	Cytochrome C biogenesis protein
KAE73_RS01600	COG0316	Belongs to the HesB IscA family
KAE73_RS01605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KAE73_RS01610	COG0018	arginyl-trna synthetase
KAE73_RS01625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KAE73_RS01645	COG0538	isocitrate dehydrogenase activity
KAE73_RS01735	COG0582	viral genome integration into host DNA
KAE73_RS01750	COG0343	queuine tRNA-ribosyltransferase activity
KAE73_RS01765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KAE73_RS01770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KAE73_RS01775	COG0629	single-stranded DNA binding
KAE73_RS01785	COG0347	Belongs to the P(II) protein family
KAE73_RS01790	COG0174	glutamine synthetase
KAE73_RS01810	COG1132	(ABC) transporter
KAE73_RS01815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KAE73_RS01820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KAE73_RS01825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KAE73_RS01830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAE73_RS01835	COG0203	ribosomal protein L17
KAE73_RS01840	COG0202	RNA polymerase activity
KAE73_RS01845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KAE73_RS01850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KAE73_RS01855	COG0563	adenylate kinase activity
KAE73_RS01865	COG0200	Binds to the 23S rRNA
KAE73_RS01870	COG1841	ribosomal large subunit assembly
KAE73_RS01875	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KAE73_RS01880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KAE73_RS01885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KAE73_RS01890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KAE73_RS01895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KAE73_RS01900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KAE73_RS01905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KAE73_RS01910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KAE73_RS01915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KAE73_RS01920	COG0255	Belongs to the universal ribosomal protein uL29 family
KAE73_RS01925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KAE73_RS01930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KAE73_RS01935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KAE73_RS01940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KAE73_RS01945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KAE73_RS01950	COG0089	rRNA binding
KAE73_RS01955	COG0088	Forms part of the polypeptide exit tunnel
KAE73_RS01960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KAE73_RS01965	COG0051	transcription antitermination factor activity, RNA binding
KAE73_RS01970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAE73_RS01975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KAE73_RS01980	COG0049	tRNA binding
KAE73_RS01985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KAE73_RS02000	COG0765	amino acid transport
KAE73_RS02005	COG0765	amino acid transport
KAE73_RS02010	COG1126	abc transporter atp-binding protein
KAE73_RS02020	COG0525	valine-tRNA ligase activity
KAE73_RS02035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KAE73_RS02080	COG0513	Belongs to the DEAD box helicase family
KAE73_RS02085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KAE73_RS02095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE73_RS02105	COG1196	nuclear chromosome segregation
KAE73_RS02105	COG3264	Mechanosensitive ion channel
KAE73_RS02120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KAE73_RS02120	COG4651	solute:proton antiporter activity
KAE73_RS02130	COG1253	flavin adenine dinucleotide binding
KAE73_RS02140	COG1113	amino acid transport
KAE73_RS02145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KAE73_RS02155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KAE73_RS02160	COG0028	Belongs to the TPP enzyme family
KAE73_RS02165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KAE73_RS02175	COG0330	HflC and HflK could
KAE73_RS02185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KAE73_RS02190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KAE73_RS02195	COG0477	Major facilitator Superfamily
KAE73_RS02200	COG0477	Major facilitator Superfamily
KAE73_RS02205	COG0477	Major facilitator Superfamily
KAE73_RS02235	COG0210	DNA helicase
KAE73_RS02245	COG1999	signal sequence binding
KAE73_RS02255	COG0006	proline dipeptidase activity
KAE73_RS02260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KAE73_RS02265	COG0497	DNA recombination
KAE73_RS02270	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KAE73_RS02285	COG0849	cell division
KAE73_RS02295	COG1181	Belongs to the D-alanine--D-alanine ligase family
KAE73_RS02300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KAE73_RS02305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KAE73_RS02310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KAE73_RS02320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KAE73_RS02325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KAE73_RS02335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KAE73_RS02350	COG0275	rRNA processing
KAE73_RS02360	COG0741	lytic transglycosylase activity
KAE73_RS02385	COG1335	isochorismatase
KAE73_RS02430	COG2968	Membrane
KAE73_RS02435	COG2983	Belongs to the UPF0260 family
KAE73_RS02440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAE73_RS02450	COG0668	transmembrane transport
KAE73_RS02465	COG3161	chorismate lyase activity
KAE73_RS02470	COG0505	Belongs to the CarA family
KAE73_RS02490	COG1278	Cold shock
KAE73_RS02495	COG0436	Aminotransferase
KAE73_RS02500	COG0583	DNA-binding transcription factor activity
KAE73_RS02505	COG0492	ferredoxin-NADP+ reductase activity
KAE73_RS02510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KAE73_RS02525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KAE73_RS02535	COG0556	nucleotide-excision repair
KAE73_RS02545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAE73_RS02550	COG0745	RESPONSE REGULATOR receiver
KAE73_RS02555	COG2205	protein histidine kinase activity
KAE73_RS02570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KAE73_RS02580	COG1496	oxidoreductase activity
KAE73_RS02595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KAE73_RS02600	COG0193	aminoacyl-tRNA hydrolase activity
KAE73_RS02605	COG1376	ErfK ybiS ycfS ynhG family protein
KAE73_RS02610	COG0012	GTP binding
KAE73_RS02630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KAE73_RS02640	COG0714	Associated with various cellular activities
KAE73_RS02665	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KAE73_RS02670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAE73_RS02675	COG0482	sulfurtransferase activity
KAE73_RS02740	COG0444	Belongs to the ABC transporter superfamily
KAE73_RS02745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KAE73_RS02750	COG0601	transmembrane transport
KAE73_RS02755	COG0747	negative chemotaxis
KAE73_RS02760	COG0747	negative chemotaxis
KAE73_RS02765	COG0519	Catalyzes the synthesis of GMP from XMP
KAE73_RS02770	COG1570	exodeoxyribonuclease VII activity
KAE73_RS02775	COG0747	negative chemotaxis
KAE73_RS02795	COG0730	response to heat
KAE73_RS02805	COG2086	electron transfer activity
KAE73_RS02835	COG0792	nuclease activity
KAE73_RS02840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KAE73_RS02845	COG0489	protein tyrosine kinase activity
KAE73_RS02850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KAE73_RS02855	COG0594	ribonuclease P activity
KAE73_RS02865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KAE73_RS02875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KAE73_RS02880	COG0588	phosphoglycerate mutase activity
KAE73_RS02910	COG3023	N-Acetylmuramoyl-L-alanine amidase
KAE73_RS02925	COG1546	Belongs to the CinA family
KAE73_RS02925	COG1058	Belongs to the CinA family
KAE73_RS02930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KAE73_RS02930	COG0473	3-isopropylmalate dehydrogenase activity
KAE73_RS02945	COG2814	Major facilitator Superfamily
KAE73_RS03000	COG0735	belongs to the Fur family
KAE73_RS03030	COG1054	Belongs to the UPF0176 family
KAE73_RS03035	COG0800	Aldolase
KAE73_RS03080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAE73_RS03080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KAE73_RS03085	COG0509	glycine decarboxylation via glycine cleavage system
KAE73_RS03090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KAE73_RS03100	COG2835	tetraacyldisaccharide 4'-kinase activity
KAE73_RS03110	COG1396	sequence-specific DNA binding
KAE73_RS03115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KAE73_RS03130	COG1464	Belongs to the NlpA lipoprotein family
KAE73_RS03135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KAE73_RS03140	COG2011	ABC-type metal ion transport system permease component
KAE73_RS03260	COG1192	Involved in chromosome partitioning
KAE73_RS03270	COG0196	riboflavin kinase activity
KAE73_RS03295	COG3838	Conjugal transfer protein Trbc
KAE73_RS03300	COG3702	type iv secretory pathway
KAE73_RS03305	COG3451	type IV secretory pathway VirB4
KAE73_RS03315	COG3704	protein secretion by the type IV secretion system
KAE73_RS03325	COG3736	Type IV secretory pathway, component VirB8
KAE73_RS03330	COG3504	Conjugal transfer protein
KAE73_RS03335	COG2948	multi-organism process
KAE73_RS03340	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
KAE73_RS03350	COG2184	nucleotidyltransferase activity
KAE73_RS03355	COG3505	Type IV secretory pathway VirD4
KAE73_RS03360	COG2184	nucleotidyltransferase activity
KAE73_RS03370	COG2184	nucleotidyltransferase activity
KAE73_RS03390	COG2184	nucleotidyltransferase activity
KAE73_RS03400	COG0728	peptidoglycan biosynthetic process
KAE73_RS03405	COG0180	Tryptophanyl-tRNA synthetase
KAE73_RS03415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KAE73_RS03420	COG2824	Alkylphosphonate utilization operon protein PhnA
KAE73_RS03430	COG0459	protein refolding
KAE73_RS03435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KAE73_RS03445	COG1396	sequence-specific DNA binding
KAE73_RS03450	COG0033	Phosphoglucomutase
KAE73_RS03470	COG1396	sequence-specific DNA binding
KAE73_RS03480	COG0124	histidyl-tRNA synthetase
KAE73_RS03485	COG0284	orotidine-5'-phosphate decarboxylase activity
KAE73_RS03535	COG0739	heme binding
KAE73_RS03545	COG3920	Histidine kinase
KAE73_RS03560	COG0784	Response regulator, receiver
KAE73_RS03680	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KAE73_RS03685	COG0424	maF-like protein
KAE73_RS03690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KAE73_RS03695	COG1396	sequence-specific DNA binding
KAE73_RS03700	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KAE73_RS03710	COG1396	sequence-specific DNA binding
KAE73_RS03765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KAE73_RS03775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KAE73_RS03780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KAE73_RS03785	COG0457	Tetratricopeptide repeat
KAE73_RS03810	COG1396	sequence-specific DNA binding
KAE73_RS03815	COG1396	sequence-specific DNA binding
KAE73_RS03835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KAE73_RS03985	COG0756	dUTP diphosphatase activity
KAE73_RS04010	COG0848	biopolymer transport protein
KAE73_RS04035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KAE73_RS04040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KAE73_RS04045	COG0037	tRNA processing
KAE73_RS04055	COG2885	chlorophyll binding
KAE73_RS04065	COG0217	transcriptional regulatory protein
KAE73_RS04075	COG0823	Involved in the tonB-independent uptake of proteins
KAE73_RS04095	COG0824	Thioesterase
KAE73_RS04100	COG2255	four-way junction helicase activity
KAE73_RS04105	COG0632	four-way junction helicase activity
KAE73_RS04110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KAE73_RS04125	COG0352	thiamine-phosphate diphosphorylase activity
KAE73_RS04135	COG1396	sequence-specific DNA binding
KAE73_RS04155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KAE73_RS04160	COG0483	inositol monophosphate 1-phosphatase activity
KAE73_RS04165	COG1132	(ABC) transporter
KAE73_RS04170	COG0254	rRNA binding
KAE73_RS04180	COG3588	fructose-bisphosphate aldolase
KAE73_RS04185	COG0126	phosphoglycerate kinase activity
KAE73_RS04215	COG0469	pyruvate kinase activity
KAE73_RS04225	COG3750	Belongs to the UPF0335 family
KAE73_RS04235	COG0488	(ABC) transporter
KAE73_RS04255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAE73_RS04265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KAE73_RS04275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KAE73_RS04280	COG0142	geranyltranstransferase activity
KAE73_RS04300	COG0542	response to heat
KAE73_RS04305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KAE73_RS04320	COG1566	PFAM secretion protein HlyD family protein
KAE73_RS04330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KAE73_RS04335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KAE73_RS04340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KAE73_RS04345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KAE73_RS04350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KAE73_RS04375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KAE73_RS04395	COG0495	leucyl-tRNA aminoacylation
KAE73_RS04405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KAE73_RS04410	COG2884	Cell division ATP-binding protein ftsE
KAE73_RS04430	COG1136	(ABC) transporter
KAE73_RS04430	COG0577	efflux transmembrane transporter activity
KAE73_RS04435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAE73_RS04440	COG1538	Outer membrane efflux protein
KAE73_RS04455	COG1674	ftsk spoiiie
KAE73_RS04460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KAE73_RS04595	COG3504	Conjugal transfer protein
KAE73_RS04635	COG0335	large ribosomal subunit rRNA binding
KAE73_RS04640	COG0336	Belongs to the RNA methyltransferase TrmD family
KAE73_RS04645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KAE73_RS04690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KAE73_RS04705	COG0138	bifunctional purine biosynthesis protein purh
KAE73_RS04715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KAE73_RS04715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KAE73_RS04720	COG0501	Belongs to the peptidase M48B family
KAE73_RS04730	COG0228	four-way junction DNA binding
KAE73_RS04740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KAE73_RS04745	COG0288	reversible hydration of carbon dioxide
KAE73_RS04750	COG2902	Dehydrogenase
KAE73_RS04775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KAE73_RS04790	COG0745	RESPONSE REGULATOR receiver
KAE73_RS04815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAE73_RS04820	COG1671	Belongs to the UPF0178 family
KAE73_RS04835	COG0287	Prephenate dehydrogenase
KAE73_RS04845	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KAE73_RS04870	COG0351	phosphomethylpyrimidine kinase
KAE73_RS04880	COG1686	Belongs to the peptidase S11 family
KAE73_RS04885	COG0523	cobalamin synthesis protein
KAE73_RS04890	COG3034	peptidoglycan biosynthetic process
KAE73_RS04895	COG0825	malonyl-CoA metabolic process
KAE73_RS04905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KAE73_RS04910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KAE73_RS04930	COG1320	monovalent cation:proton antiporter activity
KAE73_RS04935	COG2212	antiporter activity
KAE73_RS04940	COG1863	multisubunit Na H antiporter MnhE subunit
KAE73_RS04945	COG0651	ATP synthesis coupled electron transport
KAE73_RS04950	COG1006	Multisubunit Na H antiporter MnhC subunit
KAE73_RS04955	COG2111	Na H antiporter
KAE73_RS04955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KAE73_RS04965	COG0019	diaminopimelate decarboxylase activity
KAE73_RS04985	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAE73_RS04990	COG0567	Dehydrogenase, E1 component
KAE73_RS05000	COG0045	succinate-CoA ligase (ADP-forming) activity
KAE73_RS05005	COG0039	L-malate dehydrogenase activity
KAE73_RS05010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KAE73_RS05020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KAE73_RS05025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAE73_RS05030	COG0552	protein localization to endoplasmic reticulum
KAE73_RS05035	COG2917	probably involved in intracellular septation
KAE73_RS05040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KAE73_RS05055	COG0357	Ribosomal RNA small subunit methyltransferase G
KAE73_RS05060	COG0445	tRNA wobble uridine modification
KAE73_RS05065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KAE73_RS05070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KAE73_RS05075	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KAE73_RS05080	COG0424	maF-like protein
KAE73_RS05085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KAE73_RS05090	COG0237	dephospho-CoA kinase activity
KAE73_RS05100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAE73_RS05100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KAE73_RS05110	COG0670	Belongs to the BI1 family
KAE73_RS05120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KAE73_RS05130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KAE73_RS05130	COG0116	Belongs to the methyltransferase superfamily
KAE73_RS05140	COG0776	regulation of translation
KAE73_RS05155	COG1137	ATPase activity
KAE73_RS05165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAE73_RS05175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KAE73_RS05180	COG1280	lysine exporter protein (LysE YggA)
KAE73_RS05195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KAE73_RS05220	COG2205	protein histidine kinase activity
KAE73_RS05225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KAE73_RS05235	COG0285	dihydrofolate synthase activity
KAE73_RS05240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KAE73_RS05255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KAE73_RS05260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KAE73_RS05265	COG2226	methyltransferase
KAE73_RS05275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KAE73_RS05280	COG0606	chelatase, subunit chli
KAE73_RS05295	COG1132	(ABC) transporter
KAE73_RS05300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KAE73_RS05315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KAE73_RS05320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KAE73_RS05325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KAE73_RS05330	COG1420	regulation of RNA biosynthetic process
KAE73_RS05335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KAE73_RS05350	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAE73_RS05350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KAE73_RS05360	COG2205	protein histidine kinase activity
KAE73_RS05365	COG0745	RESPONSE REGULATOR receiver
KAE73_RS05370	COG1652	LysM domain
KAE73_RS05380	COG0443	Heat shock 70 kDa protein
KAE73_RS05385	COG0484	heat shock protein binding
KAE73_RS05400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KAE73_RS05405	COG0697	spore germination
KAE73_RS05410	COG0481	GTPase activity
KAE73_RS05415	COG2171	N-acyltransferase activity
KAE73_RS05425	COG0101	tRNA pseudouridine synthase activity
KAE73_RS05430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KAE73_RS05435	COG0242	peptide deformylase activity
KAE73_RS05465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KAE73_RS05470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KAE73_RS05475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KAE73_RS05480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KAE73_RS05480	COG0072	phenylalanine-tRNA ligase activity
KAE73_RS05490	COG1121	(ABC) transporter
KAE73_RS05495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KAE73_RS05500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KAE73_RS05505	COG2832	Protein of unknown function (DUF454)
KAE73_RS05510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KAE73_RS05515	COG3459	Glycosyltransferase 36 associated
KAE73_RS05520	COG0539	negative regulation of cytoplasmic translation
KAE73_RS05525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KAE73_RS05530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KAE73_RS05545	COG0129	dihydroxy-acid dehydratase activity
KAE73_RS05550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KAE73_RS05555	COG0281	malic enzyme
KAE73_RS05555	COG0280	phosphate acetyltransferase
KAE73_RS05560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KAE73_RS05565	COG3030	protein affecting phage T7 exclusion by the F plasmid
KAE73_RS05585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KAE73_RS05595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KAE73_RS05605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAE73_RS05610	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KAE73_RS05615	COG4133	protoheme IX ABC transporter activity
KAE73_RS05620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KAE73_RS05625	COG0268	Binds directly to 16S ribosomal RNA
KAE73_RS05630	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KAE73_RS05645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KAE73_RS05650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KAE73_RS05655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KAE73_RS05665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KAE73_RS05670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KAE73_RS05675	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAE73_RS05685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAE73_RS05700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KAE73_RS05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KAE73_RS05730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KAE73_RS05735	COG0166	Belongs to the GPI family
KAE73_RS05745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KAE73_RS05750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KAE73_RS05760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KAE73_RS05760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KAE73_RS05835	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KAE73_RS05840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KAE73_RS05845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KAE73_RS05850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KAE73_RS05855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KAE73_RS05860	COG0799	negative regulation of ribosome biogenesis
KAE73_RS05865	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KAE73_RS05875	COG0793	Belongs to the peptidase S41A family
KAE73_RS05880	COG0494	nUDIX hydrolase
KAE73_RS05885	COG5342	invasion associated locus B
KAE73_RS05895	COG1872	DUF167
KAE73_RS05900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KAE73_RS05905	COG1217	gtp-binding protein TYPA
KAE73_RS05910	COG2239	Acts as a magnesium transporter
KAE73_RS05915	COG0339	signal peptide processing
KAE73_RS05925	COG2951	lytic endotransglycosylase activity
KAE73_RS05930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KAE73_RS05935	COG0517	IMP dehydrogenase activity
KAE73_RS05935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KAE73_RS05950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KAE73_RS05970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KAE73_RS05970	COG0519	Catalyzes the synthesis of GMP from XMP
KAE73_RS05975	COG0584	glycerophosphoryl diester phosphodiesterase
KAE73_RS05980	COG3842	ATPase activity
KAE73_RS05985	COG0395	ABC-type sugar transport system, permease component
KAE73_RS05990	COG1175	transmembrane transport
KAE73_RS06000	COG0803	Belongs to the bacterial solute-binding protein 9 family
KAE73_RS06005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KAE73_RS06010	COG1121	(ABC) transporter
KAE73_RS06020	COG1780	Probably involved in ribonucleotide reductase function
KAE73_RS06025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KAE73_RS06035	COG2890	protein-(glutamine-N5) methyltransferase activity
KAE73_RS06040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KAE73_RS06050	COG0653	protein targeting
KAE73_RS06055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KAE73_RS06060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KAE73_RS06065	COG0494	nUDIX hydrolase
KAE73_RS06075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KAE73_RS06080	COG1072	(Pantothenic acid kinase))
KAE73_RS06085	COG0252	asparaginase activity
KAE73_RS06090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KAE73_RS06095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KAE73_RS06100	COG2813	Specifically methylates the guanine in position
KAE73_RS06105	COG1185	polyribonucleotide nucleotidyltransferase activity
KAE73_RS06110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KAE73_RS06120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KAE73_RS06125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KAE73_RS06130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KAE73_RS06140	COG0195	Participates in both transcription termination and antitermination
KAE73_RS06140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KAE73_RS06145	COG0779	Required for maturation of 30S ribosomal subunits
KAE73_RS06150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KAE73_RS06155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KAE73_RS06160	COG1396	sequence-specific DNA binding
KAE73_RS06165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KAE73_RS06175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KAE73_RS06180	COG1702	phosphate starvation-inducible protein PhoH
KAE73_RS06185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KAE73_RS06195	COG1214	PFAM Peptidase M22, glycoprotease
KAE73_RS06200	COG2855	membrane
KAE73_RS06205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KAE73_RS06210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KAE73_RS06215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KAE73_RS06230	COG1605	Chorismate mutase
KAE73_RS06230	COG0077	Prephenate dehydratase
KAE73_RS06235	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KAE73_RS06240	COG3474	cytochrome
KAE73_RS06245	COG4174	ABC transporter (Permease)
KAE73_RS06250	COG4239	(ABC) transporter, permease
KAE73_RS06255	COG4172	Belongs to the ABC transporter superfamily
KAE73_RS06270	COG0189	ligase activity
KAE73_RS06280	COG0573	inorganic phosphate transmembrane transporter activity
KAE73_RS06290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KAE73_RS06295	COG0704	Plays a role in the regulation of phosphate uptake
KAE73_RS06310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KAE73_RS06330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE73_RS06335	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE73_RS06340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE73_RS06345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KAE73_RS06355	COG0590	tRNA wobble adenosine to inosine editing
KAE73_RS06360	COG1187	pseudouridine synthase activity
KAE73_RS06365	COG0742	ribosomal rna small subunit methyltransferase
KAE73_RS06370	COG0312	modulator of DNA gyrase
KAE73_RS06375	COG0483	inositol monophosphate 1-phosphatase activity
KAE73_RS06385	COG1519	Transferase
KAE73_RS06390	COG1663	tetraacyldisaccharide 4'-kinase activity
KAE73_RS06400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KAE73_RS06405	COG0717	Belongs to the dCTP deaminase family
KAE73_RS06410	COG1304	FMN binding
KAE73_RS06425	COG1113	amino acid transport
KAE73_RS06430	COG1122	ATPase activity
KAE73_RS06440	COG1268	BioY protein
KAE73_RS06475	COG0582	viral genome integration into host DNA
KAE73_RS06480	COG3561	AntA/AntB antirepressor
KAE73_RS06485	COG3561	AntA/AntB antirepressor
KAE73_RS06490	COG3077	Addiction module antitoxin, RelB DinJ family
KAE73_RS06495	COG3041	Addiction module toxin RelE StbE family
KAE73_RS06540	COG3561	AntA/AntB antirepressor
KAE73_RS06670	COG3646	Phage regulatory protein
KAE73_RS06680	COG3646	Phage regulatory protein
KAE73_RS06750	COG3077	Addiction module antitoxin, RelB DinJ family
KAE73_RS06755	COG3041	Addiction module toxin RelE StbE family
KAE73_RS06765	COG3561	AntA/AntB antirepressor
KAE73_RS06780	COG3561	AntA/AntB antirepressor
KAE73_RS06810	COG0629	single-stranded DNA binding
KAE73_RS06825	COG3093	addiction module antidote protein HigA
KAE73_RS06890	COG3561	AntA/AntB antirepressor
KAE73_RS06920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KAE73_RS06930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KAE73_RS06935	COG0564	pseudouridine synthase activity
KAE73_RS06960	COG1970	mechanosensitive ion channel activity
KAE73_RS06965	COG0167	dihydroorotate dehydrogenase activity
KAE73_RS06980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KAE73_RS06985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KAE73_RS06990	COG0363	glucosamine-6-phosphate deaminase activity
KAE73_RS06995	COG0129	dihydroxy-acid dehydratase activity
KAE73_RS07000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KAE73_RS07025	COG1823	symporter activity
KAE73_RS07030	COG2226	methyltransferase
KAE73_RS07035	COG1040	competence protein
KAE73_RS07040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KAE73_RS07045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KAE73_RS07050	COG0527	aspartate kinase activity
KAE73_RS07055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAE73_RS07065	COG0471	metal ion transport
KAE73_RS07065	COG3273	potassium ion transport
KAE73_RS07075	COG1160	GTP binding
KAE73_RS07090	COG0356	it plays a direct role in the translocation of protons across the membrane
KAE73_RS07100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KAE73_RS07105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KAE73_RS07110	COG0751	glycine-tRNA ligase activity
KAE73_RS07125	COG0142	geranyltranstransferase activity
KAE73_RS07140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KAE73_RS07150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KAE73_RS07155	COG0009	L-threonylcarbamoyladenylate synthase
KAE73_RS07160	COG0277	FAD linked oxidase domain protein
KAE73_RS07175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KAE73_RS07180	COG0259	pyridoxamine-phosphate oxidase activity
KAE73_RS07185	COG0484	heat shock protein binding
KAE73_RS07190	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KAE73_RS07195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KAE73_RS07200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KAE73_RS07200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KAE73_RS07205	COG1722	exodeoxyribonuclease VII activity
KAE73_RS07210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KAE73_RS07225	COG0312	modulator of DNA gyrase
KAE73_RS07235	COG0109	protoheme IX farnesyltransferase activity
KAE73_RS07240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KAE73_RS07245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KAE73_RS07250	COG0328	RNA-DNA hybrid ribonuclease activity
KAE73_RS07260	COG1678	Uncharacterized ACR, COG1678
KAE73_RS07270	COG0612	Peptidase, M16
KAE73_RS07300	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KAE73_RS07305	COG1194	a g-specific adenine glycosylase
KAE73_RS07315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KAE73_RS07315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KAE73_RS07320	COG0574	Belongs to the PEP-utilizing enzyme family
KAE73_RS07320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KAE73_RS07335	COG2166	iron-sulfur cluster assembly
KAE73_RS07350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KAE73_RS07375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KAE73_RS07400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KAE73_RS07405	COG1138	Cytochrome C-type biogenesis protein
KAE73_RS07410	COG3088	subunit of a heme lyase
KAE73_RS07415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KAE73_RS07420	COG0745	RESPONSE REGULATOR receiver
KAE73_RS07425	COG0642	Histidine kinase
KAE73_RS07430	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KAE73_RS07435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KAE73_RS07445	COG2202	Pas domain
KAE73_RS07445	COG2205	protein histidine kinase activity
KAE73_RS07450	COG0308	aminopeptidase N
KAE73_RS07460	COG0351	phosphomethylpyrimidine kinase
KAE73_RS07470	COG2022	thiamine diphosphate biosynthetic process
KAE73_RS07485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KAE73_RS07495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KAE73_RS07500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KAE73_RS07505	COG4558	Periplasmic binding protein
KAE73_RS07510	COG3720	iron ion transport
KAE73_RS07515	COG4771	TonB-dependent receptor
KAE73_RS07525	COG0741	lytic transglycosylase activity
KAE73_RS07530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KAE73_RS07535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KAE73_RS07540	COG1573	uracil-dna glycosylase
KAE73_RS07545	COG1758	RNA polymerase activity
KAE73_RS07555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KAE73_RS07565	COG0736	holo-[acyl-carrier-protein] synthase activity
KAE73_RS07575	COG0571	ribonuclease III activity
KAE73_RS07585	COG1381	Involved in DNA repair and RecF pathway recombination
KAE73_RS07590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KAE73_RS07595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KAE73_RS07600	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
KAE73_RS07605	COG0354	folic acid binding
KAE73_RS07610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KAE73_RS07620	COG0215	cysteine-tRNA ligase activity
KAE73_RS07625	COG2323	membrane
KAE73_RS07630	COG5265	(ABC) transporter
KAE73_RS07635	COG0688	phosphatidylethanolamine metabolic process
KAE73_RS07640	COG1183	phosphatidylcholine synthase activity
KAE73_RS07645	COG1028	Short-chain dehydrogenase reductase Sdr
KAE73_RS07650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KAE73_RS07665	COG0305	Participates in initiation and elongation during chromosome replication
KAE73_RS07670	COG0359	binds to the 23S rRNA
KAE73_RS07680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KAE73_RS07685	COG0360	Binds together with S18 to 16S ribosomal RNA
KAE73_RS07690	COG0671	phosphoesterase, PA-phosphatase related
KAE73_RS07695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KAE73_RS07705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KAE73_RS07710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KAE73_RS07715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KAE73_RS07720	COG0194	GDP metabolic process
KAE73_RS07725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KAE73_RS07730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KAE73_RS07740	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KAE73_RS07770	COG0477	Major facilitator Superfamily
KAE73_RS07795	COG0105	UTP biosynthetic process
KAE73_RS07800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KAE73_RS07805	COG0322	excinuclease ABC activity
KAE73_RS07810	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KAE73_RS07830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAE73_RS07835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KAE73_RS07840	COG0805	protein transport
KAE73_RS07845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KAE73_RS07850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KAE73_RS07855	COG1388	LysM domain
KAE73_RS07855	COG4942	peptidase
KAE73_RS07860	COG1862	Preprotein translocase
KAE73_RS07880	COG0149	triose-phosphate isomerase activity
KAE73_RS07890	COG0504	CTP synthase activity
KAE73_RS07895	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KAE73_RS07900	COG0148	phosphopyruvate hydratase activity
KAE73_RS07920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KAE73_RS07925	COG0022	dehydrogenase e1 component
KAE73_RS07925	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAE73_RS07930	COG0508	dehydrogenase complex catalyzes the overall conversion of
KAE73_RS07935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KAE73_RS07940	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KAE73_RS07945	COG2867	negative regulation of translational initiation
KAE73_RS07950	COG1058	Belongs to the CinA family
KAE73_RS07950	COG1546	Belongs to the CinA family
KAE73_RS07955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KAE73_RS07955	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KAE73_RS07960	COG1959	2 iron, 2 sulfur cluster binding
KAE73_RS07965	COG5000	phosphorelay sensor kinase activity
KAE73_RS07970	COG2204	response regulator
KAE73_RS07975	COG0569	domain protein
KAE73_RS07985	COG0740	serine-type endopeptidase activity
KAE73_RS07990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KAE73_RS08005	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KAE73_RS08015	COG0544	peptidyl-prolyl cis-trans isomerase activity
KAE73_RS08020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KAE73_RS08030	COG4765	Protein conserved in bacteria
KAE73_RS08040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KAE73_RS08055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KAE73_RS08065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KAE73_RS08075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KAE73_RS08080	COG0081	regulation of translation
KAE73_RS08085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KAE73_RS08090	COG0222	ribosome binding
KAE73_RS08100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KAE73_RS08105	COG0789	Transcriptional regulator
KAE73_RS08115	COG1760	l-serine dehydratase
KAE73_RS08125	COG1686	Belongs to the peptidase S11 family
KAE73_RS08130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KAE73_RS08140	COG0537	adenosine 5'-monophosphoramidase activity
KAE73_RS08155	COG0052	Belongs to the universal ribosomal protein uS2 family
KAE73_RS08160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KAE73_RS08165	COG0528	UMP kinase activity
KAE73_RS08170	COG0233	cytoplasmic translational termination
KAE73_RS08180	COG0750	zinc metalloprotease
KAE73_RS08190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAE73_RS08195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KAE73_RS08200	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAE73_RS08205	COG3494	Protein of unknown function (DUF1009)
KAE73_RS08210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KAE73_RS08215	COG1126	abc transporter atp-binding protein
KAE73_RS08225	COG4215	(ABC) transporter