locus-tag	class	description
RM11_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RM11_RS00010	COG0424	maF-like protein
RM11_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RM11_RS00020	COG0237	dephospho-CoA kinase activity
RM11_RS00025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RM11_RS00030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RM11_RS00030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RM11_RS00040	COG0670	Belongs to the BI1 family
RM11_RS00050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RM11_RS00070	COG0776	regulation of translation
RM11_RS00085	COG1137	ATPase activity
RM11_RS00090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RM11_RS00100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RM11_RS00120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RM11_RS00140	COG0802	atpase or kinase
RM11_RS00145	COG2205	protein histidine kinase activity
RM11_RS00150	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RM11_RS00160	COG0702	epimerase
RM11_RS00165	COG0285	dihydrofolate synthase activity
RM11_RS00170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RM11_RS00180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RM11_RS00185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RM11_RS00190	COG2226	methyltransferase
RM11_RS00220	COG1132	(ABC) transporter
RM11_RS00225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RM11_RS00240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RM11_RS00245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RM11_RS00250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RM11_RS00255	COG1420	regulation of RNA biosynthetic process
RM11_RS00260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RM11_RS00275	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RM11_RS00275	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RM11_RS00285	COG2205	protein histidine kinase activity
RM11_RS00290	COG0745	RESPONSE REGULATOR receiver
RM11_RS00295	COG1652	LysM domain
RM11_RS00305	COG0443	Heat shock 70 kDa protein
RM11_RS00310	COG0484	heat shock protein binding
RM11_RS00315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RM11_RS00320	COG0697	spore germination
RM11_RS00325	COG0481	GTPase activity
RM11_RS00330	COG2171	N-acyltransferase activity
RM11_RS00340	COG0101	tRNA pseudouridine synthase activity
RM11_RS00345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RM11_RS00350	COG0242	peptide deformylase activity
RM11_RS00380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RM11_RS00385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RM11_RS00390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RM11_RS00395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RM11_RS00395	COG0072	phenylalanine-tRNA ligase activity
RM11_RS00405	COG1121	(ABC) transporter
RM11_RS00410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RM11_RS00415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RM11_RS00420	COG2832	Protein of unknown function (DUF454)
RM11_RS00425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RM11_RS00430	COG3459	Glycosyltransferase 36 associated
RM11_RS00435	COG0539	negative regulation of cytoplasmic translation
RM11_RS00440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RM11_RS00445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RM11_RS00460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RM11_RS00465	COG0281	malic enzyme
RM11_RS00465	COG0280	phosphate acetyltransferase
RM11_RS00470	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RM11_RS00475	COG3030	protein affecting phage T7 exclusion by the F plasmid
RM11_RS00490	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RM11_RS00500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RM11_RS00520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RM11_RS00525	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RM11_RS00530	COG4133	protoheme IX ABC transporter activity
RM11_RS00535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RM11_RS00540	COG0268	Binds directly to 16S ribosomal RNA
RM11_RS00545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RM11_RS00560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RM11_RS00565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RM11_RS00570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RM11_RS00585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RM11_RS00590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RM11_RS00600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RM11_RS00615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RM11_RS00635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RM11_RS00640	COG0166	Belongs to the GPI family
RM11_RS00650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RM11_RS00655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RM11_RS00660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RM11_RS00660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RM11_RS00710	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RM11_RS00715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RM11_RS00720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RM11_RS00725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RM11_RS00730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RM11_RS00750	COG0793	Belongs to the peptidase S41A family
RM11_RS00755	COG0494	nUDIX hydrolase
RM11_RS00760	COG5342	invasion associated locus B
RM11_RS00770	COG1872	DUF167
RM11_RS00775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RM11_RS00780	COG1217	gtp-binding protein TYPA
RM11_RS00785	COG2239	Acts as a magnesium transporter
RM11_RS00800	COG2951	lytic endotransglycosylase activity
RM11_RS00805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RM11_RS00810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RM11_RS00810	COG0517	IMP dehydrogenase activity
RM11_RS00820	COG2204	response regulator
RM11_RS00825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RM11_RS00835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RM11_RS00835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RM11_RS00840	COG0519	Catalyzes the synthesis of GMP from XMP
RM11_RS00840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RM11_RS00845	COG0584	glycerophosphoryl diester phosphodiesterase
RM11_RS00850	COG3842	ATPase activity
RM11_RS00855	COG0395	ABC-type sugar transport system, permease component
RM11_RS00870	COG0803	Belongs to the bacterial solute-binding protein 9 family
RM11_RS00880	COG1121	(ABC) transporter
RM11_RS00890	COG1780	Probably involved in ribonucleotide reductase function
RM11_RS00895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RM11_RS00905	COG2890	protein-(glutamine-N5) methyltransferase activity
RM11_RS00910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RM11_RS00920	COG0653	protein targeting
RM11_RS00925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RM11_RS00930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RM11_RS00935	COG0494	nUDIX hydrolase
RM11_RS00945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RM11_RS00950	COG1072	(Pantothenic acid kinase))
RM11_RS00955	COG0252	asparaginase activity
RM11_RS00960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RM11_RS00965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RM11_RS00970	COG2813	Specifically methylates the guanine in position
RM11_RS00975	COG1185	polyribonucleotide nucleotidyltransferase activity
RM11_RS00980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RM11_RS00990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RM11_RS00995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RM11_RS01000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RM11_RS01010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RM11_RS01010	COG0195	Participates in both transcription termination and antitermination
RM11_RS01015	COG0779	Required for maturation of 30S ribosomal subunits
RM11_RS01020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RM11_RS01030	COG1396	sequence-specific DNA binding
RM11_RS01035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RM11_RS01040	COG4535	Mg2 and Co2 transporter CorC
RM11_RS01045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RM11_RS01050	COG1702	phosphate starvation-inducible protein PhoH
RM11_RS01055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RM11_RS01065	COG1214	PFAM Peptidase M22, glycoprotease
RM11_RS01075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RM11_RS01080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RM11_RS01085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RM11_RS01100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RM11_RS01105	COG3474	cytochrome
RM11_RS01130	COG0189	ligase activity
RM11_RS01150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RM11_RS01155	COG0704	Plays a role in the regulation of phosphate uptake
RM11_RS01170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RM11_RS01190	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RM11_RS01195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RM11_RS01200	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RM11_RS01205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RM11_RS01215	COG0590	tRNA wobble adenosine to inosine editing
RM11_RS01225	COG0742	ribosomal rna small subunit methyltransferase
RM11_RS01245	COG0312	modulator of DNA gyrase
RM11_RS01250	COG0483	inositol monophosphate 1-phosphatase activity
RM11_RS01260	COG1519	Transferase
RM11_RS01265	COG1663	tetraacyldisaccharide 4'-kinase activity
RM11_RS01275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RM11_RS01285	COG0717	Belongs to the dCTP deaminase family
RM11_RS01290	COG1304	FMN binding
RM11_RS01335	COG1113	amino acid transport
RM11_RS01340	COG1122	ATPase activity
RM11_RS01345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RM11_RS01350	COG1268	BioY protein
RM11_RS01385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RM11_RS01395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RM11_RS01400	COG0564	pseudouridine synthase activity
RM11_RS01420	COG2205	protein histidine kinase activity
RM11_RS01425	COG1970	mechanosensitive ion channel activity
RM11_RS01430	COG0167	dihydroorotate dehydrogenase activity
RM11_RS01445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RM11_RS01450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RM11_RS01455	COG0363	glucosamine-6-phosphate deaminase activity
RM11_RS01460	COG0129	dihydroxy-acid dehydratase activity
RM11_RS01465	COG0129	dihydroxy-acid dehydratase activity
RM11_RS01470	COG0129	dihydroxy-acid dehydratase activity
RM11_RS01480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RM11_RS01505	COG1823	symporter activity
RM11_RS01515	COG1040	competence protein
RM11_RS01520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RM11_RS01525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RM11_RS01530	COG0527	aspartate kinase activity
RM11_RS01535	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RM11_RS01545	COG3273	potassium ion transport
RM11_RS01545	COG0471	metal ion transport
RM11_RS01555	COG1160	GTP binding
RM11_RS01565	COG0356	it plays a direct role in the translocation of protons across the membrane
RM11_RS01575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RM11_RS01580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RM11_RS01585	COG0751	glycine-tRNA ligase activity
RM11_RS01600	COG0142	geranyltranstransferase activity
RM11_RS01615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RM11_RS01650	COG0012	GTP binding
RM11_RS01655	COG1376	ErfK ybiS ycfS ynhG family protein
RM11_RS01670	COG0193	aminoacyl-tRNA hydrolase activity
RM11_RS01675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RM11_RS01695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RM11_RS01700	COG1496	oxidoreductase activity
RM11_RS01710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RM11_RS01735	COG0745	RESPONSE REGULATOR receiver
RM11_RS01740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RM11_RS01750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RM11_RS01755	COG0009	L-threonylcarbamoyladenylate synthase
RM11_RS01760	COG0277	FAD linked oxidase domain protein
RM11_RS01770	COG0151	Belongs to the GarS family
RM11_RS01780	COG0259	pyridoxamine-phosphate oxidase activity
RM11_RS01785	COG0484	heat shock protein binding
RM11_RS01790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RM11_RS01795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RM11_RS01800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RM11_RS01800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RM11_RS01805	COG1722	exodeoxyribonuclease VII activity
RM11_RS01810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RM11_RS01840	COG0109	protoheme IX farnesyltransferase activity
RM11_RS01845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RM11_RS01855	COG0328	RNA-DNA hybrid ribonuclease activity
RM11_RS01865	COG1678	Uncharacterized ACR, COG1678
RM11_RS01880	COG0612	Peptidase, M16
RM11_RS01905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RM11_RS01910	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RM11_RS01915	COG1194	a g-specific adenine glycosylase
RM11_RS01930	COG0574	Belongs to the PEP-utilizing enzyme family
RM11_RS01930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RM11_RS01950	COG2166	iron-sulfur cluster assembly
RM11_RS01965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RM11_RS01975	COG2274	protein secretion by the type I secretion system
RM11_RS02000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RM11_RS02025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RM11_RS02030	COG1138	Cytochrome C-type biogenesis protein
RM11_RS02035	COG3088	subunit of a heme lyase
RM11_RS02040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RM11_RS02045	COG0745	RESPONSE REGULATOR receiver
RM11_RS02050	COG5002	protein histidine kinase activity
RM11_RS02055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RM11_RS02060	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RM11_RS02070	COG2205	protein histidine kinase activity
RM11_RS02070	COG2202	Pas domain
RM11_RS02075	COG0308	aminopeptidase N
RM11_RS02085	COG0351	phosphomethylpyrimidine kinase
RM11_RS02095	COG2022	thiamine diphosphate biosynthetic process
RM11_RS02115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RM11_RS02120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RM11_RS02125	COG4558	Periplasmic binding protein
RM11_RS02130	COG3720	iron ion transport
RM11_RS02135	COG4771	TonB-dependent receptor
RM11_RS02150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RM11_RS02155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RM11_RS02160	COG1573	uracil-dna glycosylase
RM11_RS02165	COG1758	RNA polymerase activity
RM11_RS02175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RM11_RS02185	COG0736	holo-[acyl-carrier-protein] synthase activity
RM11_RS02195	COG0571	ribonuclease III activity
RM11_RS02205	COG1381	Involved in DNA repair and RecF pathway recombination
RM11_RS02210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RM11_RS02215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RM11_RS02220	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RM11_RS02240	COG0215	cysteine-tRNA ligase activity
RM11_RS02250	COG5265	(ABC) transporter
RM11_RS02255	COG0688	phosphatidylethanolamine metabolic process
RM11_RS02260	COG1183	phosphatidylcholine synthase activity
RM11_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
RM11_RS02270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RM11_RS02285	COG0305	Participates in initiation and elongation during chromosome replication
RM11_RS02290	COG0359	binds to the 23S rRNA
RM11_RS02300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RM11_RS02305	COG0360	Binds together with S18 to 16S ribosomal RNA
RM11_RS02310	COG0671	phosphoesterase, PA-phosphatase related
RM11_RS02315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RM11_RS02325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RM11_RS02330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RM11_RS02335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RM11_RS02340	COG0194	GDP metabolic process
RM11_RS02345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RM11_RS02350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RM11_RS02360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RM11_RS02390	COG0477	Major facilitator Superfamily
RM11_RS02410	COG0105	UTP biosynthetic process
RM11_RS02415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RM11_RS02420	COG0322	excinuclease ABC activity
RM11_RS02425	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RM11_RS02435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RM11_RS02440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RM11_RS02445	COG0805	protein transport
RM11_RS02450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RM11_RS02455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RM11_RS02460	COG1388	LysM domain
RM11_RS02460	COG4942	peptidase
RM11_RS02475	COG1562	ergosterol biosynthetic process
RM11_RS02485	COG0149	triose-phosphate isomerase activity
RM11_RS02495	COG0504	CTP synthase activity
RM11_RS02500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RM11_RS02505	COG0148	phosphopyruvate hydratase activity
RM11_RS02520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RM11_RS02525	COG0508	dehydrogenase complex catalyzes the overall conversion of
RM11_RS02525	COG0022	dehydrogenase e1 component
RM11_RS02530	COG0508	dehydrogenase complex catalyzes the overall conversion of
RM11_RS02535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RM11_RS02540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RM11_RS02545	COG2867	negative regulation of translational initiation
RM11_RS02550	COG1546	Belongs to the CinA family
RM11_RS02550	COG1058	Belongs to the CinA family
RM11_RS02555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RM11_RS02555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RM11_RS02560	COG1959	2 iron, 2 sulfur cluster binding
RM11_RS02565	COG5000	phosphorelay sensor kinase activity
RM11_RS02570	COG2204	response regulator
RM11_RS02575	COG0569	domain protein
RM11_RS02585	COG0740	serine-type endopeptidase activity
RM11_RS02590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RM11_RS02665	COG0071	Belongs to the small heat shock protein (HSP20) family
RM11_RS02695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RM11_RS02700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RM11_RS02705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RM11_RS02710	COG0280	phosphate acetyltransferase
RM11_RS02710	COG0281	malic enzyme
RM11_RS02720	COG1923	regulation of RNA biosynthetic process
RM11_RS02725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RM11_RS02735	COG1612	heme a metabolic process
RM11_RS02740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RM11_RS02745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RM11_RS02750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RM11_RS02765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RM11_RS02770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RM11_RS02785	COG0416	fatty acid biosynthetic process
RM11_RS02790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RM11_RS02795	COG0776	regulation of translation
RM11_RS02805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RM11_RS02810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RM11_RS02820	COG0302	gtp cyclohydrolase
RM11_RS02865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RM11_RS02870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RM11_RS02875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RM11_RS02880	COG0649	NAD binding
RM11_RS02885	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RM11_RS02890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RM11_RS02900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RM11_RS02905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RM11_RS02915	COG0713	ATP synthesis coupled electron transport
RM11_RS02930	COG1007	ATP synthesis coupled electron transport
RM11_RS02945	COG0442	prolyl-tRNA aminoacylation
RM11_RS02955	COG1136	(ABC) transporter
RM11_RS02960	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RM11_RS02965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RM11_RS02980	COG1530	ribonuclease E activity
RM11_RS02985	COG0860	N-Acetylmuramoyl-L-alanine amidase
RM11_RS02990	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RM11_RS03000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RM11_RS03005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RM11_RS03010	COG2945	thiolester hydrolase activity
RM11_RS03020	COG0719	Fe-S assembly protein
RM11_RS03025	COG0396	ATPase activity
RM11_RS03030	COG0719	Fe-S assembly protein
RM11_RS03035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RM11_RS03055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RM11_RS03060	COG1183	phosphatidylcholine synthase activity
RM11_RS03065	COG0321	lipoyl(octanoyl) transferase activity
RM11_RS03065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RM11_RS03070	COG0084	hydrolase, TatD family'
RM11_RS03075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RM11_RS03085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RM11_RS03090	COG1686	Belongs to the peptidase S11 family
RM11_RS03105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RM11_RS03120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RM11_RS03125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RM11_RS03135	COG1489	DNA binding
RM11_RS03140	COG0024	Methionine aminopeptidase
RM11_RS03145	COG2003	Belongs to the UPF0758 family
RM11_RS03155	COG0596	Alpha beta hydrolase
RM11_RS03165	COG1278	Cold shock
RM11_RS03185	COG0411	ABC transporter
RM11_RS03195	COG0154	amidase activity
RM11_RS03200	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RM11_RS03205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RM11_RS03215	COG0540	Belongs to the ATCase OTCase family
RM11_RS03220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RM11_RS03225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RM11_RS03230	COG0758	DNA mediated transformation
RM11_RS03240	COG0557	exoribonuclease II activity
RM11_RS03245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RM11_RS03255	COG1573	uracil-dna glycosylase
RM11_RS03260	COG1522	sequence-specific DNA binding
RM11_RS03285	COG0511	ligase activity, forming carbon-carbon bonds
RM11_RS03290	COG0439	Biotin carboxylase
RM11_RS03320	COG0321	lipoyl(octanoyl) transferase activity
RM11_RS03325	COG0187	DNA topoisomerase II activity
RM11_RS03335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RM11_RS03340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RM11_RS03345	COG0784	Response regulator, receiver
RM11_RS03375	COG2986	histidine ammonia-lyase
RM11_RS03390	COG0513	Belongs to the DEAD box helicase family
RM11_RS03395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RM11_RS03395	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
RM11_RS03405	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RM11_RS03420	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RM11_RS03430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RM11_RS03435	COG0372	Belongs to the citrate synthase family
RM11_RS03445	COG4215	(ABC) transporter
RM11_RS03455	COG1126	abc transporter atp-binding protein
RM11_RS03460	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RM11_RS03470	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RM11_RS03475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RM11_RS03480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RM11_RS03485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RM11_RS03490	COG0750	zinc metalloprotease
RM11_RS03500	COG0233	cytoplasmic translational termination
RM11_RS03505	COG0528	UMP kinase activity
RM11_RS03510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RM11_RS03515	COG0052	Belongs to the universal ribosomal protein uS2 family
RM11_RS03540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RM11_RS03545	COG1686	Belongs to the peptidase S11 family
RM11_RS03555	COG1760	l-serine dehydratase
RM11_RS03565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RM11_RS03570	COG0085	RNA polymerase activity
RM11_RS03575	COG0222	ribosome binding
RM11_RS03580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RM11_RS03585	COG0081	regulation of translation
RM11_RS03590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RM11_RS03600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RM11_RS03610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RM11_RS03625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RM11_RS03645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RM11_RS03650	COG0544	peptidyl-prolyl cis-trans isomerase activity
RM11_RS03695	COG0628	permease
RM11_RS03700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RM11_RS03705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RM11_RS03725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RM11_RS03735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RM11_RS03745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RM11_RS03750	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RM11_RS03755	COG0047	phosphoribosylformylglycinamidine synthase activity
RM11_RS03760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RM11_RS03775	COG2814	Major facilitator Superfamily
RM11_RS03780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RM11_RS03785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RM11_RS03790	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RM11_RS03795	COG0248	Ppx GppA phosphatase
RM11_RS03800	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RM11_RS03810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RM11_RS03820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RM11_RS03825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RM11_RS03830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RM11_RS03835	COG0785	Cytochrome C biogenesis protein
RM11_RS03845	COG0316	Belongs to the HesB IscA family
RM11_RS03850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RM11_RS03855	COG0018	arginyl-trna synthetase
RM11_RS03870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RM11_RS03895	COG0538	isocitrate dehydrogenase activity
RM11_RS03930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RM11_RS03935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RM11_RS03940	COG0629	single-stranded DNA binding
RM11_RS03950	COG0347	Belongs to the P(II) protein family
RM11_RS03955	COG0174	glutamine synthetase
RM11_RS03975	COG1132	(ABC) transporter
RM11_RS03980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RM11_RS03985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RM11_RS03990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RM11_RS04000	COG0203	ribosomal protein L17
RM11_RS04005	COG0202	RNA polymerase activity
RM11_RS04010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RM11_RS04015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RM11_RS04020	COG0563	adenylate kinase activity
RM11_RS04025	COG0201	protein transport
RM11_RS04030	COG0200	Binds to the 23S rRNA
RM11_RS04035	COG1841	ribosomal large subunit assembly
RM11_RS04040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RM11_RS04045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RM11_RS04050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RM11_RS04055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RM11_RS04060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RM11_RS04065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RM11_RS04070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RM11_RS04075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RM11_RS04080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RM11_RS04085	COG0255	Belongs to the universal ribosomal protein uL29 family
RM11_RS04090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RM11_RS04095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RM11_RS04100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RM11_RS04105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RM11_RS04110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RM11_RS04115	COG0089	rRNA binding
RM11_RS04120	COG0088	Forms part of the polypeptide exit tunnel
RM11_RS04125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RM11_RS04130	COG0051	transcription antitermination factor activity, RNA binding
RM11_RS04140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RM11_RS04145	COG0049	tRNA binding
RM11_RS04150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RM11_RS04165	COG0765	amino acid transport
RM11_RS04170	COG0765	amino acid transport
RM11_RS04175	COG1126	abc transporter atp-binding protein
RM11_RS04180	COG0525	valine-tRNA ligase activity
RM11_RS04195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RM11_RS04220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RM11_RS04230	COG1196	nuclear chromosome segregation
RM11_RS04230	COG3264	Mechanosensitive ion channel
RM11_RS04245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RM11_RS04245	COG4651	solute:proton antiporter activity
RM11_RS04260	COG1253	flavin adenine dinucleotide binding
RM11_RS04270	COG1113	amino acid transport
RM11_RS04275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RM11_RS04285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RM11_RS04295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RM11_RS04320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RM11_RS04325	COG0477	Major facilitator Superfamily
RM11_RS04360	COG1999	signal sequence binding
RM11_RS04370	COG0006	proline dipeptidase activity
RM11_RS04375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RM11_RS04385	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RM11_RS04400	COG0849	cell division
RM11_RS04410	COG1181	Belongs to the D-alanine--D-alanine ligase family
RM11_RS04415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RM11_RS04420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RM11_RS04425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RM11_RS04435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RM11_RS04440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RM11_RS04465	COG0275	rRNA processing
RM11_RS04500	COG1335	isochorismatase
RM11_RS04555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RM11_RS04560	COG0358	DNA primase activity
RM11_RS04565	COG0668	transmembrane transport
RM11_RS04580	COG3161	chorismate lyase activity
RM11_RS04585	COG0505	Belongs to the CarA family
RM11_RS04600	COG1278	Cold shock
RM11_RS04605	COG0436	Aminotransferase
RM11_RS04610	COG0583	DNA-binding transcription factor activity
RM11_RS04615	COG0492	ferredoxin-NADP+ reductase activity
RM11_RS04620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RM11_RS04630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RM11_RS04640	COG0556	nucleotide-excision repair
RM11_RS04650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RM11_RS04655	COG0617	tRNA 3'-terminal CCA addition
RM11_RS04660	COG0714	Associated with various cellular activities
RM11_RS04685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RM11_RS04695	COG0482	sulfurtransferase activity
RM11_RS04745	COG4608	Belongs to the ABC transporter superfamily
RM11_RS04750	COG0444	Belongs to the ABC transporter superfamily
RM11_RS04755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RM11_RS04760	COG0601	transmembrane transport
RM11_RS04765	COG0747	negative chemotaxis
RM11_RS04770	COG0747	negative chemotaxis
RM11_RS04775	COG0519	Catalyzes the synthesis of GMP from XMP
RM11_RS04780	COG1570	exodeoxyribonuclease VII activity
RM11_RS04790	COG0730	response to heat
RM11_RS04800	COG2086	electron transfer activity
RM11_RS04825	COG0792	nuclease activity
RM11_RS04830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RM11_RS04835	COG0489	protein tyrosine kinase activity
RM11_RS04840	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RM11_RS04845	COG0594	ribonuclease P activity
RM11_RS04855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RM11_RS04865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RM11_RS04870	COG0588	phosphoglycerate mutase activity
RM11_RS04895	COG3023	N-Acetylmuramoyl-L-alanine amidase
RM11_RS04900	COG0284	orotidine-5'-phosphate decarboxylase activity
RM11_RS04950	COG0735	belongs to the Fur family
RM11_RS04980	COG1054	Belongs to the UPF0176 family
RM11_RS05005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RM11_RS05005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RM11_RS05010	COG0509	glycine decarboxylation via glycine cleavage system
RM11_RS05015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RM11_RS05025	COG2835	tetraacyldisaccharide 4'-kinase activity
RM11_RS05035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RM11_RS05100	COG4607	ABC-type enterochelin transport system periplasmic component
RM11_RS05110	COG4605	iron ion homeostasis
RM11_RS05115	COG4604	ABC transporter, ATP-binding protein
RM11_RS05170	COG0196	riboflavin kinase activity
RM11_RS05195	COG3838	Conjugal transfer protein Trbc
RM11_RS05200	COG3702	type iv secretory pathway
RM11_RS05205	COG3451	type IV secretory pathway VirB4
RM11_RS05215	COG3704	protein secretion by the type IV secretion system
RM11_RS05225	COG3736	Type IV secretory pathway, component VirB8
RM11_RS05230	COG3504	Conjugal transfer protein
RM11_RS05235	COG2948	multi-organism process
RM11_RS05240	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
RM11_RS05255	COG3505	Type IV secretory pathway VirD4
RM11_RS05265	COG2184	nucleotidyltransferase activity
RM11_RS05290	COG0728	peptidoglycan biosynthetic process
RM11_RS05295	COG0180	Tryptophanyl-tRNA synthetase
RM11_RS05305	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RM11_RS05310	COG0459	protein refolding
RM11_RS05315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RM11_RS05325	COG0033	Phosphoglucomutase
RM11_RS05335	COG0124	histidyl-tRNA synthetase
RM11_RS05340	COG0284	orotidine-5'-phosphate decarboxylase activity
RM11_RS05390	COG0739	heme binding
RM11_RS05400	COG3920	Histidine kinase
RM11_RS05420	COG0784	Response regulator, receiver
RM11_RS05425	COG2202	Pas domain
RM11_RS05425	COG3920	Histidine kinase
RM11_RS05545	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RM11_RS05550	COG0424	maF-like protein
RM11_RS05555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RM11_RS05570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RM11_RS05580	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RM11_RS05605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RM11_RS05610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RM11_RS05615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RM11_RS05620	COG0457	Tetratricopeptide repeat
RM11_RS05650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RM11_RS05770	COG1238	metal cluster binding
RM11_RS05795	COG0756	dUTP diphosphatase activity
RM11_RS05805	COG0848	biopolymer transport protein
RM11_RS05825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RM11_RS05830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RM11_RS05835	COG0037	tRNA processing
RM11_RS05855	COG2885	chlorophyll binding
RM11_RS05865	COG0217	transcriptional regulatory protein
RM11_RS05875	COG0823	Involved in the tonB-independent uptake of proteins
RM11_RS05895	COG0824	Thioesterase
RM11_RS05900	COG2255	four-way junction helicase activity
RM11_RS05905	COG0632	four-way junction helicase activity
RM11_RS05910	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RM11_RS05945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RM11_RS05950	COG0483	inositol monophosphate 1-phosphatase activity
RM11_RS05955	COG1132	(ABC) transporter
RM11_RS05960	COG0254	rRNA binding
RM11_RS05965	COG3588	fructose-bisphosphate aldolase
RM11_RS05970	COG0126	phosphoglycerate kinase activity
RM11_RS06000	COG0469	pyruvate kinase activity
RM11_RS06010	COG3750	Belongs to the UPF0335 family
RM11_RS06015	COG0488	(ABC) transporter
RM11_RS06035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RM11_RS06045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RM11_RS06055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RM11_RS06060	COG0142	geranyltranstransferase activity
RM11_RS06065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RM11_RS06075	COG1566	PFAM secretion protein HlyD family protein
RM11_RS06085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RM11_RS06090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RM11_RS06095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RM11_RS06100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RM11_RS06105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RM11_RS06115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RM11_RS06125	COG0495	leucyl-tRNA aminoacylation
RM11_RS06130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RM11_RS06140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RM11_RS06150	COG2884	Cell division ATP-binding protein ftsE
RM11_RS06170	COG1136	(ABC) transporter
RM11_RS06170	COG0577	efflux transmembrane transporter activity
RM11_RS06175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RM11_RS06195	COG1674	ftsk spoiiie
RM11_RS06200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RM11_RS06310	COG3504	Conjugal transfer protein
RM11_RS06345	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RM11_RS06355	COG0335	large ribosomal subunit rRNA binding
RM11_RS06360	COG0336	Belongs to the RNA methyltransferase TrmD family
RM11_RS06365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RM11_RS06400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RM11_RS06410	COG0138	bifunctional purine biosynthesis protein purh
RM11_RS06420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RM11_RS06420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RM11_RS06425	COG0501	Belongs to the peptidase M48B family
RM11_RS06430	COG5508	conserved small protein
RM11_RS06435	COG0228	four-way junction DNA binding
RM11_RS06445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RM11_RS06455	COG2902	Dehydrogenase
RM11_RS06465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RM11_RS06480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RM11_RS06500	COG0745	RESPONSE REGULATOR receiver
RM11_RS06530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RM11_RS06550	COG0287	Prephenate dehydrogenase
RM11_RS06580	COG0351	phosphomethylpyrimidine kinase
RM11_RS06590	COG1686	Belongs to the peptidase S11 family
RM11_RS06600	COG3034	peptidoglycan biosynthetic process
RM11_RS06605	COG0825	malonyl-CoA metabolic process
RM11_RS06615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RM11_RS06620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RM11_RS06635	COG3895	Periplasmic Protein
RM11_RS06640	COG1320	monovalent cation:proton antiporter activity
RM11_RS06645	COG2212	antiporter activity
RM11_RS06650	COG1863	multisubunit Na H antiporter MnhE subunit
RM11_RS06655	COG0651	ATP synthesis coupled electron transport
RM11_RS06660	COG1006	Multisubunit Na H antiporter MnhC subunit
RM11_RS06665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RM11_RS06665	COG2111	Na H antiporter
RM11_RS06690	COG0508	dehydrogenase complex catalyzes the overall conversion of
RM11_RS06700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RM11_RS06705	COG0045	succinate-CoA ligase (ADP-forming) activity
RM11_RS06710	COG0039	L-malate dehydrogenase activity
RM11_RS06715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RM11_RS06725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RM11_RS06730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RM11_RS06735	COG0552	protein localization to endoplasmic reticulum
RM11_RS06740	COG2917	probably involved in intracellular septation
RM11_RS06760	COG0357	Ribosomal RNA small subunit methyltransferase G
RM11_RS06765	COG0445	tRNA wobble uridine modification
RM11_RS06770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RM11_RS06775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template