locus-tag	class	description
B11cv2_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B11cv2_RS00025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B11cv2_RS00030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B11cv2_RS00035	COG1845	cytochrome c oxidase, subunit III
B11cv2_RS00040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B11cv2_RS00045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B11cv2_RS00055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B11cv2_RS00075	COG0791	NLP P60 protein
B11cv2_RS00080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B11cv2_RS00085	COG1072	(Pantothenic acid kinase))
B11cv2_RS00090	COG0252	asparaginase activity
B11cv2_RS00095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B11cv2_RS00100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B11cv2_RS00105	COG2813	Specifically methylates the guanine in position
B11cv2_RS00110	COG1185	polyribonucleotide nucleotidyltransferase activity
B11cv2_RS00115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B11cv2_RS00125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B11cv2_RS00130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B11cv2_RS00135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B11cv2_RS00145	COG0195	Participates in both transcription termination and antitermination
B11cv2_RS00145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B11cv2_RS00150	COG0779	Required for maturation of 30S ribosomal subunits
B11cv2_RS00155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B11cv2_RS00160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B11cv2_RS00165	COG1396	sequence-specific DNA binding
B11cv2_RS00180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B11cv2_RS00185	COG1702	phosphate starvation-inducible protein PhoH
B11cv2_RS00190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B11cv2_RS00200	COG1214	PFAM Peptidase M22, glycoprotease
B11cv2_RS00205	COG2855	membrane
B11cv2_RS00215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B11cv2_RS00230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B11cv2_RS00235	COG3474	cytochrome
B11cv2_RS00245	COG4239	(ABC) transporter, permease
B11cv2_RS00250	COG4172	Belongs to the ABC transporter superfamily
B11cv2_RS00260	COG0189	ligase activity
B11cv2_RS00270	COG0573	inorganic phosphate transmembrane transporter activity
B11cv2_RS00280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B11cv2_RS00285	COG0704	Plays a role in the regulation of phosphate uptake
B11cv2_RS00300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B11cv2_RS00305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B11cv2_RS00320	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B11cv2_RS00325	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B11cv2_RS00330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B11cv2_RS00335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B11cv2_RS00345	COG0590	tRNA wobble adenosine to inosine editing
B11cv2_RS00350	COG1187	pseudouridine synthase activity
B11cv2_RS00355	COG0742	ribosomal rna small subunit methyltransferase
B11cv2_RS00360	COG1752	Esterase of the alpha-beta hydrolase superfamily
B11cv2_RS00365	COG0312	modulator of DNA gyrase
B11cv2_RS00370	COG0483	inositol monophosphate 1-phosphatase activity
B11cv2_RS00385	COG1519	Transferase
B11cv2_RS00390	COG1663	tetraacyldisaccharide 4'-kinase activity
B11cv2_RS00400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B11cv2_RS00405	COG0717	Belongs to the dCTP deaminase family
B11cv2_RS00410	COG1304	FMN binding
B11cv2_RS00415	COG1268	BioY protein
B11cv2_RS00420	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B11cv2_RS00425	COG1122	ATPase activity
B11cv2_RS00430	COG1113	amino acid transport
B11cv2_RS00435	COG2900	Belongs to the SlyX family
B11cv2_RS00445	COG0629	single-stranded DNA binding
B11cv2_RS00620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B11cv2_RS00630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B11cv2_RS00635	COG0564	pseudouridine synthase activity
B11cv2_RS00650	COG1970	mechanosensitive ion channel activity
B11cv2_RS00655	COG0167	dihydroorotate dehydrogenase activity
B11cv2_RS00665	COG0174	glutamine synthetase
B11cv2_RS00670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B11cv2_RS00675	COG0363	glucosamine-6-phosphate deaminase activity
B11cv2_RS00680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B11cv2_RS00695	COG3572	ergothioneine biosynthetic process
B11cv2_RS00700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B11cv2_RS00710	COG2184	nucleotidyltransferase activity
B11cv2_RS00725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B11cv2_RS00730	COG0166	Belongs to the GPI family
B11cv2_RS00810	COG4962	Type ii secretion system protein e
B11cv2_RS00860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B11cv2_RS00865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B11cv2_RS00870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B11cv2_RS00880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B11cv2_RS00885	COG0799	negative regulation of ribosome biogenesis
B11cv2_RS00890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B11cv2_RS00900	COG0793	Belongs to the peptidase S41A family
B11cv2_RS00910	COG5342	invasion associated locus B
B11cv2_RS00920	COG1872	DUF167
B11cv2_RS00925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B11cv2_RS00930	COG1217	gtp-binding protein TYPA
B11cv2_RS00935	COG2239	Acts as a magnesium transporter
B11cv2_RS00940	COG0339	signal peptide processing
B11cv2_RS00945	COG2951	lytic endotransglycosylase activity
B11cv2_RS00950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B11cv2_RS00955	COG0517	IMP dehydrogenase activity
B11cv2_RS00955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B11cv2_RS00970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B11cv2_RS00985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B11cv2_RS00985	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B11cv2_RS00990	COG0519	Catalyzes the synthesis of GMP from XMP
B11cv2_RS00990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B11cv2_RS01000	COG3842	ATPase activity
B11cv2_RS01005	COG0395	ABC-type sugar transport system, permease component
B11cv2_RS01010	COG1175	transmembrane transport
B11cv2_RS01020	COG0803	Belongs to the bacterial solute-binding protein 9 family
B11cv2_RS01030	COG1121	(ABC) transporter
B11cv2_RS01040	COG1780	Probably involved in ribonucleotide reductase function
B11cv2_RS01045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B11cv2_RS01055	COG2890	protein-(glutamine-N5) methyltransferase activity
B11cv2_RS01060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B11cv2_RS01070	COG0653	protein targeting
B11cv2_RS01075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B11cv2_RS01080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B11cv2_RS01085	COG0494	nUDIX hydrolase
B11cv2_RS01090	COG1823	symporter activity
B11cv2_RS01095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B11cv2_RS01100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B11cv2_RS01110	COG0356	it plays a direct role in the translocation of protons across the membrane
B11cv2_RS01120	COG1160	GTP binding
B11cv2_RS01130	COG3273	potassium ion transport
B11cv2_RS01130	COG0471	metal ion transport
B11cv2_RS01140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B11cv2_RS01145	COG0527	aspartate kinase activity
B11cv2_RS01150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B11cv2_RS01155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B11cv2_RS01160	COG1040	competence protein
B11cv2_RS01170	COG0751	glycine-tRNA ligase activity
B11cv2_RS01185	COG0142	geranyltranstransferase activity
B11cv2_RS01200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B11cv2_RS01205	COG1472	Belongs to the glycosyl hydrolase 3 family
B11cv2_RS01210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B11cv2_RS01215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B11cv2_RS01220	COG0805	protein transport
B11cv2_RS01225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B11cv2_RS01230	COG2184	nucleotidyltransferase activity
B11cv2_RS01235	COG2184	nucleotidyltransferase activity
B11cv2_RS01240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B11cv2_RS01245	COG4942	peptidase
B11cv2_RS01245	COG1388	LysM domain
B11cv2_RS01255	COG1862	Preprotein translocase
B11cv2_RS01290	COG0523	cobalamin synthesis protein
B11cv2_RS01310	COG0006	proline dipeptidase activity
B11cv2_RS01320	COG1999	signal sequence binding
B11cv2_RS01340	COG1335	isochorismatase
B11cv2_RS01375	COG0275	rRNA processing
B11cv2_RS01400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B11cv2_RS01405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B11cv2_RS01415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B11cv2_RS01420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B11cv2_RS01425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B11cv2_RS01430	COG1181	Belongs to the D-alanine--D-alanine ligase family
B11cv2_RS01440	COG0849	cell division
B11cv2_RS01455	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B11cv2_RS01460	COG0497	DNA recombination
B11cv2_RS01465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B11cv2_RS01510	COG0477	Major facilitator Superfamily
B11cv2_RS01515	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B11cv2_RS01520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B11cv2_RS01535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B11cv2_RS01540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B11cv2_RS01545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B11cv2_RS01550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B11cv2_RS01570	COG2184	nucleotidyltransferase activity
B11cv2_RS01595	COG3077	Addiction module antitoxin, RelB DinJ family
B11cv2_RS01675	COG3561	AntA/AntB antirepressor
B11cv2_RS01855	COG3561	AntA/AntB antirepressor
B11cv2_RS01890	COG1598	PFAM Uncharacterised protein family UPF0150
B11cv2_RS01920	COG1598	PFAM Uncharacterised protein family UPF0150
B11cv2_RS02005	COG3561	AntA/AntB antirepressor
B11cv2_RS02020	COG0513	Belongs to the DEAD box helicase family
B11cv2_RS02035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B11cv2_RS02050	COG0525	valine-tRNA ligase activity
B11cv2_RS02055	COG1126	abc transporter atp-binding protein
B11cv2_RS02060	COG0765	amino acid transport
B11cv2_RS02065	COG0765	amino acid transport
B11cv2_RS02080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B11cv2_RS02085	COG0049	tRNA binding
B11cv2_RS02090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B11cv2_RS02095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B11cv2_RS02105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B11cv2_RS02110	COG0088	Forms part of the polypeptide exit tunnel
B11cv2_RS02115	COG0089	rRNA binding
B11cv2_RS02120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B11cv2_RS02125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B11cv2_RS02130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B11cv2_RS02135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B11cv2_RS02140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B11cv2_RS02145	COG0255	Belongs to the universal ribosomal protein uL29 family
B11cv2_RS02150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B11cv2_RS02155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B11cv2_RS02160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B11cv2_RS02165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B11cv2_RS02170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B11cv2_RS02175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B11cv2_RS02180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B11cv2_RS02185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B11cv2_RS02190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B11cv2_RS02195	COG1841	ribosomal large subunit assembly
B11cv2_RS02200	COG0200	Binds to the 23S rRNA
B11cv2_RS02210	COG0563	adenylate kinase activity
B11cv2_RS02215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B11cv2_RS02220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B11cv2_RS02225	COG0202	RNA polymerase activity
B11cv2_RS02230	COG0203	ribosomal protein L17
B11cv2_RS02235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B11cv2_RS02240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B11cv2_RS02245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B11cv2_RS02250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B11cv2_RS02255	COG1132	(ABC) transporter
B11cv2_RS02260	COG0564	pseudouridine synthase activity
B11cv2_RS02270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B11cv2_RS02285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B11cv2_RS02295	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B11cv2_RS02305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B11cv2_RS02310	COG0081	regulation of translation
B11cv2_RS02315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B11cv2_RS02320	COG0222	ribosome binding
B11cv2_RS02325	COG0085	RNA polymerase activity
B11cv2_RS02330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B11cv2_RS02335	COG0789	Transcriptional regulator
B11cv2_RS02345	COG1760	l-serine dehydratase
B11cv2_RS02355	COG1686	Belongs to the peptidase S11 family
B11cv2_RS02375	COG0052	Belongs to the universal ribosomal protein uS2 family
B11cv2_RS02380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B11cv2_RS02385	COG0528	UMP kinase activity
B11cv2_RS02390	COG0233	cytoplasmic translational termination
B11cv2_RS02405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B11cv2_RS02410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B11cv2_RS02415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B11cv2_RS02420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B11cv2_RS02430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B11cv2_RS02435	COG1126	abc transporter atp-binding protein
B11cv2_RS02445	COG4215	(ABC) transporter
B11cv2_RS02455	COG0372	Belongs to the citrate synthase family
B11cv2_RS02460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B11cv2_RS02465	COG0658	competence protein
B11cv2_RS02465	COG2333	competence protein COMEC
B11cv2_RS02475	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B11cv2_RS02500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B11cv2_RS02500	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B11cv2_RS02505	COG0513	Belongs to the DEAD box helicase family
B11cv2_RS02530	COG2814	Major facilitator Superfamily
B11cv2_RS02565	COG0071	Belongs to the small heat shock protein (HSP20) family
B11cv2_RS02580	COG3956	TIGRFAM MazG family protein
B11cv2_RS02590	COG1063	alcohol dehydrogenase
B11cv2_RS02595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B11cv2_RS02605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B11cv2_RS02610	COG0280	phosphate acetyltransferase
B11cv2_RS02610	COG0281	malic enzyme
B11cv2_RS02620	COG1923	regulation of RNA biosynthetic process
B11cv2_RS02625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B11cv2_RS02635	COG1612	heme a metabolic process
B11cv2_RS02645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B11cv2_RS02650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B11cv2_RS02655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B11cv2_RS02655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B11cv2_RS02665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B11cv2_RS02670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B11cv2_RS02675	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B11cv2_RS02685	COG0416	fatty acid biosynthetic process
B11cv2_RS02690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B11cv2_RS02695	COG0776	regulation of translation
B11cv2_RS02705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B11cv2_RS02710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B11cv2_RS02720	COG0302	gtp cyclohydrolase
B11cv2_RS02740	COG3023	N-Acetylmuramoyl-L-alanine amidase
B11cv2_RS02755	COG0511	ligase activity, forming carbon-carbon bonds
B11cv2_RS02760	COG0439	Biotin carboxylase
B11cv2_RS02780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B11cv2_RS02785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B11cv2_RS02790	COG1573	uracil-dna glycosylase
B11cv2_RS02800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B11cv2_RS02810	COG0557	exoribonuclease II activity
B11cv2_RS02815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B11cv2_RS02825	COG0758	DNA mediated transformation
B11cv2_RS02830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B11cv2_RS02835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B11cv2_RS02840	COG0540	Belongs to the ATCase OTCase family
B11cv2_RS02850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B11cv2_RS02855	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B11cv2_RS02860	COG0154	amidase activity
B11cv2_RS02890	COG1278	Cold shock
B11cv2_RS02900	COG2267	carboxylic ester hydrolase activity
B11cv2_RS02905	COG2945	thiolester hydrolase activity
B11cv2_RS02915	COG0719	Fe-S assembly protein
B11cv2_RS02920	COG0396	ATPase activity
B11cv2_RS02925	COG0719	Fe-S assembly protein
B11cv2_RS02930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B11cv2_RS02950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B11cv2_RS02955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B11cv2_RS02960	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B11cv2_RS02965	COG0649	NAD binding
B11cv2_RS02970	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B11cv2_RS02975	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B11cv2_RS02985	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B11cv2_RS02990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B11cv2_RS03000	COG0713	ATP synthesis coupled electron transport
B11cv2_RS03015	COG1007	ATP synthesis coupled electron transport
B11cv2_RS03030	COG0442	prolyl-tRNA aminoacylation
B11cv2_RS03040	COG1136	(ABC) transporter
B11cv2_RS03045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B11cv2_RS03050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B11cv2_RS03055	COG4166	transmembrane transport
B11cv2_RS03065	COG1530	ribonuclease E activity
B11cv2_RS03070	COG0860	N-Acetylmuramoyl-L-alanine amidase
B11cv2_RS03075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B11cv2_RS03085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B11cv2_RS03090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B11cv2_RS03105	COG0024	Methionine aminopeptidase
B11cv2_RS03110	COG1489	DNA binding
B11cv2_RS03120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B11cv2_RS03125	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B11cv2_RS03130	COG0037	tRNA processing
B11cv2_RS03135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B11cv2_RS03165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B11cv2_RS03170	COG1183	phosphatidylcholine synthase activity
B11cv2_RS03175	COG0321	lipoyl(octanoyl) transferase activity
B11cv2_RS03175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B11cv2_RS03180	COG0084	hydrolase, TatD family'
B11cv2_RS03190	COG0470	DNA polymerase III
B11cv2_RS03195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B11cv2_RS03210	COG1704	LemA family
B11cv2_RS03215	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B11cv2_RS03220	COG0321	lipoyl(octanoyl) transferase activity
B11cv2_RS03225	COG0187	DNA topoisomerase II activity
B11cv2_RS03235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B11cv2_RS03240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B11cv2_RS03245	COG0784	Response regulator, receiver
B11cv2_RS03270	COG0628	permease
B11cv2_RS03275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B11cv2_RS03280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B11cv2_RS03295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B11cv2_RS03305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B11cv2_RS03315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B11cv2_RS03320	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B11cv2_RS03325	COG0047	phosphoribosylformylglycinamidine synthase activity
B11cv2_RS03330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B11cv2_RS03335	COG0271	Belongs to the BolA IbaG family
B11cv2_RS03340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B11cv2_RS03345	COG2814	Major facilitator Superfamily
B11cv2_RS03350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B11cv2_RS03370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B11cv2_RS03375	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B11cv2_RS03380	COG0248	Ppx GppA phosphatase
B11cv2_RS03385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B11cv2_RS03395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B11cv2_RS03410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B11cv2_RS03415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B11cv2_RS03420	COG0785	Cytochrome C biogenesis protein
B11cv2_RS03430	COG0316	Belongs to the HesB IscA family
B11cv2_RS03435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B11cv2_RS03440	COG0018	arginyl-trna synthetase
B11cv2_RS03455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B11cv2_RS03460	COG1494	fructose-1,6-bisphosphatase
B11cv2_RS03470	COG2184	nucleotidyltransferase activity
B11cv2_RS03485	COG0538	isocitrate dehydrogenase activity
B11cv2_RS03490	COG2814	Major facilitator Superfamily
B11cv2_RS03495	COG0343	queuine tRNA-ribosyltransferase activity
B11cv2_RS03510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B11cv2_RS03515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B11cv2_RS03530	COG0347	Belongs to the P(II) protein family
B11cv2_RS03535	COG0174	glutamine synthetase
B11cv2_RS03545	COG3838	Conjugal transfer protein Trbc
B11cv2_RS03550	COG3702	type iv secretory pathway
B11cv2_RS03555	COG3451	type IV secretory pathway VirB4
B11cv2_RS03565	COG3704	protein secretion by the type IV secretion system
B11cv2_RS03580	COG3736	Type IV secretory pathway, component VirB8
B11cv2_RS03585	COG3504	Conjugal transfer protein
B11cv2_RS03590	COG2948	multi-organism process
B11cv2_RS03595	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B11cv2_RS03600	COG2184	nucleotidyltransferase activity
B11cv2_RS03605	COG2184	nucleotidyltransferase activity
B11cv2_RS03610	COG2184	nucleotidyltransferase activity
B11cv2_RS03615	COG3505	Type IV secretory pathway VirD4
B11cv2_RS03625	COG2184	nucleotidyltransferase activity
B11cv2_RS03630	COG2184	nucleotidyltransferase activity
B11cv2_RS03635	COG3702	type iv secretory pathway
B11cv2_RS03640	COG3838	Conjugal transfer protein Trbc
B11cv2_RS03655	COG4765	Protein conserved in bacteria
B11cv2_RS03665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B11cv2_RS03670	COG0544	peptidyl-prolyl cis-trans isomerase activity
B11cv2_RS03680	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B11cv2_RS03695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B11cv2_RS03700	COG0740	serine-type endopeptidase activity
B11cv2_RS03710	COG0569	domain protein
B11cv2_RS03715	COG2204	response regulator
B11cv2_RS03720	COG5000	phosphorelay sensor kinase activity
B11cv2_RS03725	COG1959	2 iron, 2 sulfur cluster binding
B11cv2_RS03730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B11cv2_RS03730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B11cv2_RS03735	COG1546	Belongs to the CinA family
B11cv2_RS03735	COG1058	Belongs to the CinA family
B11cv2_RS03740	COG2867	negative regulation of translational initiation
B11cv2_RS03745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B11cv2_RS03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B11cv2_RS03755	COG0508	dehydrogenase complex catalyzes the overall conversion of
B11cv2_RS03760	COG0022	dehydrogenase e1 component
B11cv2_RS03760	COG0508	dehydrogenase complex catalyzes the overall conversion of
B11cv2_RS03765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B11cv2_RS03780	COG0148	phosphopyruvate hydratase activity
B11cv2_RS03785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B11cv2_RS03790	COG0504	CTP synthase activity
B11cv2_RS03800	COG0149	triose-phosphate isomerase activity
B11cv2_RS03810	COG1113	amino acid transport
B11cv2_RS03815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B11cv2_RS03820	COG3264	Mechanosensitive ion channel
B11cv2_RS03820	COG1196	nuclear chromosome segregation
B11cv2_RS03830	COG4651	solute:proton antiporter activity
B11cv2_RS03830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B11cv2_RS03840	COG1253	flavin adenine dinucleotide binding
B11cv2_RS03850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B11cv2_RS03855	COG0322	excinuclease ABC activity
B11cv2_RS03860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B11cv2_RS03865	COG0105	UTP biosynthetic process
B11cv2_RS03870	COG0488	(ABC) transporter
B11cv2_RS03890	COG2184	nucleotidyltransferase activity
B11cv2_RS03895	COG0477	Major facilitator Superfamily
B11cv2_RS03910	COG0795	lipopolysaccharide-transporting ATPase activity
B11cv2_RS03925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B11cv2_RS03930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B11cv2_RS03935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B11cv2_RS03940	COG0194	GDP metabolic process
B11cv2_RS03945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B11cv2_RS03950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B11cv2_RS03955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B11cv2_RS03965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B11cv2_RS03970	COG0671	phosphoesterase, PA-phosphatase related
B11cv2_RS03980	COG0360	Binds together with S18 to 16S ribosomal RNA
B11cv2_RS03985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B11cv2_RS03995	COG0359	binds to the 23S rRNA
B11cv2_RS04000	COG0305	Participates in initiation and elongation during chromosome replication
B11cv2_RS04015	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B11cv2_RS04025	COG1183	phosphatidylcholine synthase activity
B11cv2_RS04030	COG0688	phosphatidylethanolamine metabolic process
B11cv2_RS04035	COG5265	(ABC) transporter
B11cv2_RS04040	COG2323	membrane
B11cv2_RS04045	COG0215	cysteine-tRNA ligase activity
B11cv2_RS04055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B11cv2_RS04060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B11cv2_RS04065	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B11cv2_RS04070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B11cv2_RS04075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B11cv2_RS04080	COG1381	Involved in DNA repair and RecF pathway recombination
B11cv2_RS04090	COG0571	ribonuclease III activity
B11cv2_RS04095	COG0681	Belongs to the peptidase S26 family
B11cv2_RS04100	COG0736	holo-[acyl-carrier-protein] synthase activity
B11cv2_RS04110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B11cv2_RS04120	COG1758	RNA polymerase activity
B11cv2_RS04125	COG1573	uracil-dna glycosylase
B11cv2_RS04130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B11cv2_RS04135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B11cv2_RS04155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B11cv2_RS04155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B11cv2_RS04160	COG0509	glycine decarboxylation via glycine cleavage system
B11cv2_RS04165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B11cv2_RS04170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B11cv2_RS04175	COG2835	tetraacyldisaccharide 4'-kinase activity
B11cv2_RS04180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B11cv2_RS04205	COG4607	ABC-type enterochelin transport system periplasmic component
B11cv2_RS04210	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B11cv2_RS04215	COG4605	iron ion homeostasis
B11cv2_RS04220	COG4604	ABC transporter, ATP-binding protein
B11cv2_RS04235	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B11cv2_RS04240	COG5443	negative regulation of bacterial-type flagellum assembly
B11cv2_RS04285	COG1360	Flagellar Motor Protein
B11cv2_RS04315	COG1338	Plays a role in the flagellum-specific transport system
B11cv2_RS04325	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B11cv2_RS04335	COG1706	bacterial-type flagellum-dependent cell motility
B11cv2_RS04340	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
B11cv2_RS04345	COG4786	Flagellar basal body rod
B11cv2_RS04350	COG1677	Flagellar hook-basal body complex protein FliE
B11cv2_RS04355	COG1558	bacterial-type flagellum-dependent cell motility
B11cv2_RS04360	COG1815	bacterial-type flagellum-dependent cell motility
B11cv2_RS04365	COG1157	protein secretion by the type III secretion system
B11cv2_RS04370	COG4786	Flagellar basal body rod
B11cv2_RS04380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B11cv2_RS04385	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B11cv2_RS04395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B11cv2_RS04400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B11cv2_RS04405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B11cv2_RS04435	COG1684	flagellar biosynthetic protein fliR
B11cv2_RS04440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B11cv2_RS04445	COG0196	riboflavin kinase activity
B11cv2_RS04455	COG0728	peptidoglycan biosynthetic process
B11cv2_RS04460	COG0180	Tryptophanyl-tRNA synthetase
B11cv2_RS04470	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B11cv2_RS04475	COG0109	protoheme IX farnesyltransferase activity
B11cv2_RS04485	COG0312	modulator of DNA gyrase
B11cv2_RS04495	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B11cv2_RS04500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B11cv2_RS04505	COG1722	exodeoxyribonuclease VII activity
B11cv2_RS04510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B11cv2_RS04510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B11cv2_RS04515	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B11cv2_RS04520	COG0484	heat shock protein binding
B11cv2_RS04525	COG0259	pyridoxamine-phosphate oxidase activity
B11cv2_RS04530	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B11cv2_RS04550	COG0277	FAD linked oxidase domain protein
B11cv2_RS04555	COG0009	L-threonylcarbamoyladenylate synthase
B11cv2_RS04560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B11cv2_RS04570	COG4771	TonB-dependent receptor
B11cv2_RS04575	COG3720	iron ion transport
B11cv2_RS04580	COG4558	Periplasmic binding protein
B11cv2_RS04585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B11cv2_RS04590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B11cv2_RS04620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B11cv2_RS04635	COG2022	thiamine diphosphate biosynthetic process
B11cv2_RS04655	COG0308	aminopeptidase N
B11cv2_RS04660	COG2202	Pas domain
B11cv2_RS04660	COG2205	protein histidine kinase activity
B11cv2_RS04670	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B11cv2_RS04675	COG0642	Histidine kinase
B11cv2_RS04680	COG0745	RESPONSE REGULATOR receiver
B11cv2_RS04685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B11cv2_RS04690	COG3088	subunit of a heme lyase
B11cv2_RS04695	COG1138	Cytochrome C-type biogenesis protein
B11cv2_RS04700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B11cv2_RS04755	COG2166	iron-sulfur cluster assembly
B11cv2_RS04770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B11cv2_RS04775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B11cv2_RS04790	COG0574	Belongs to the PEP-utilizing enzyme family
B11cv2_RS04790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B11cv2_RS04795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B11cv2_RS04795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B11cv2_RS04805	COG1194	a g-specific adenine glycosylase
B11cv2_RS04810	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B11cv2_RS04820	COG0612	Peptidase, M16
B11cv2_RS04825	COG1716	ATPase activity
B11cv2_RS04825	COG5001	Diguanylate cyclase
B11cv2_RS04830	COG1678	Uncharacterized ACR, COG1678
B11cv2_RS04840	COG0328	RNA-DNA hybrid ribonuclease activity
B11cv2_RS04845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B11cv2_RS04860	COG2983	Belongs to the UPF0260 family
B11cv2_RS04865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B11cv2_RS04875	COG0668	transmembrane transport
B11cv2_RS04885	COG0505	Belongs to the CarA family
B11cv2_RS04895	COG1278	Cold shock
B11cv2_RS04900	COG0436	Aminotransferase
B11cv2_RS04905	COG0583	DNA-binding transcription factor activity
B11cv2_RS04910	COG0492	ferredoxin-NADP+ reductase activity
B11cv2_RS04915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B11cv2_RS04925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B11cv2_RS04930	COG0556	nucleotide-excision repair
B11cv2_RS04940	COG1278	Cold shock
B11cv2_RS04950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B11cv2_RS04955	COG0745	RESPONSE REGULATOR receiver
B11cv2_RS04960	COG2205	protein histidine kinase activity
B11cv2_RS04975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B11cv2_RS04985	COG1496	oxidoreductase activity
B11cv2_RS05015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B11cv2_RS05020	COG0193	aminoacyl-tRNA hydrolase activity
B11cv2_RS05025	COG1376	ErfK ybiS ycfS ynhG family protein
B11cv2_RS05030	COG0012	GTP binding
B11cv2_RS05040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B11cv2_RS05045	COG0617	tRNA 3'-terminal CCA addition
B11cv2_RS05050	COG0714	Associated with various cellular activities
B11cv2_RS05095	COG0482	sulfurtransferase activity
B11cv2_RS05150	COG0444	Belongs to the ABC transporter superfamily
B11cv2_RS05155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B11cv2_RS05160	COG0601	transmembrane transport
B11cv2_RS05165	COG0747	negative chemotaxis
B11cv2_RS05170	COG0747	negative chemotaxis
B11cv2_RS05175	COG2818	Glycosylase
B11cv2_RS05180	COG1570	exodeoxyribonuclease VII activity
B11cv2_RS05190	COG0730	response to heat
B11cv2_RS05200	COG2086	electron transfer activity
B11cv2_RS05230	COG0792	nuclease activity
B11cv2_RS05235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B11cv2_RS05245	COG0489	protein tyrosine kinase activity
B11cv2_RS05260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B11cv2_RS05265	COG0594	ribonuclease P activity
B11cv2_RS05275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B11cv2_RS05285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B11cv2_RS05290	COG0588	phosphoglycerate mutase activity
B11cv2_RS05330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B11cv2_RS05335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B11cv2_RS05345	COG3023	N-Acetylmuramoyl-L-alanine amidase
B11cv2_RS05390	COG0735	belongs to the Fur family
B11cv2_RS05415	COG1054	Belongs to the UPF0176 family
B11cv2_RS05425	COG2824	Alkylphosphonate utilization operon protein PhnA
B11cv2_RS05430	COG0459	protein refolding
B11cv2_RS05435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B11cv2_RS05445	COG0033	Phosphoglucomutase
B11cv2_RS05455	COG0124	histidyl-tRNA synthetase
B11cv2_RS05505	COG3920	Histidine kinase
B11cv2_RS05520	COG0784	Response regulator, receiver
B11cv2_RS05610	COG1783	phage Terminase large subunit
B11cv2_RS05625	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B11cv2_RS05630	COG0424	maF-like protein
B11cv2_RS05635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B11cv2_RS05640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B11cv2_RS05645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B11cv2_RS05650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B11cv2_RS05665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B11cv2_RS05670	COG1692	metallophosphoesterase
B11cv2_RS05675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B11cv2_RS05740	COG0756	dUTP diphosphatase activity
B11cv2_RS05745	COG0848	biopolymer transport protein
B11cv2_RS05765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B11cv2_RS05770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B11cv2_RS05775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B11cv2_RS05780	COG0037	tRNA processing
B11cv2_RS05790	COG2885	chlorophyll binding
B11cv2_RS05810	COG0217	transcriptional regulatory protein
B11cv2_RS05815	COG0254	rRNA binding
B11cv2_RS05820	COG1132	(ABC) transporter
B11cv2_RS05825	COG0483	inositol monophosphate 1-phosphatase activity
B11cv2_RS05830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B11cv2_RS05855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B11cv2_RS05860	COG0632	four-way junction helicase activity
B11cv2_RS05865	COG2255	four-way junction helicase activity
B11cv2_RS05870	COG0824	Thioesterase
B11cv2_RS05890	COG0823	Involved in the tonB-independent uptake of proteins
B11cv2_RS05895	COG3588	fructose-bisphosphate aldolase
B11cv2_RS05900	COG0126	phosphoglycerate kinase activity
B11cv2_RS05930	COG3750	Belongs to the UPF0335 family
B11cv2_RS05935	COG0488	(ABC) transporter
B11cv2_RS05955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B11cv2_RS05965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B11cv2_RS05975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B11cv2_RS05985	COG0142	geranyltranstransferase activity
B11cv2_RS05990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B11cv2_RS06000	COG1566	PFAM secretion protein HlyD family protein
B11cv2_RS06010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B11cv2_RS06015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B11cv2_RS06020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B11cv2_RS06025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B11cv2_RS06030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B11cv2_RS06045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B11cv2_RS06055	COG0495	leucyl-tRNA aminoacylation
B11cv2_RS06060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B11cv2_RS06070	COG2884	Cell division ATP-binding protein ftsE
B11cv2_RS06085	COG1136	(ABC) transporter
B11cv2_RS06085	COG0577	efflux transmembrane transporter activity
B11cv2_RS06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B11cv2_RS06110	COG1674	ftsk spoiiie
B11cv2_RS06115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B11cv2_RS06140	COG0335	large ribosomal subunit rRNA binding
B11cv2_RS06145	COG0336	Belongs to the RNA methyltransferase TrmD family
B11cv2_RS06150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B11cv2_RS06190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B11cv2_RS06205	COG0138	bifunctional purine biosynthesis protein purh
B11cv2_RS06215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B11cv2_RS06220	COG0501	Belongs to the peptidase M48B family
B11cv2_RS06230	COG0228	four-way junction DNA binding
B11cv2_RS06240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B11cv2_RS06250	COG2902	Dehydrogenase
B11cv2_RS06275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B11cv2_RS06280	COG0165	Argininosuccinate lyase
B11cv2_RS06290	COG0019	diaminopimelate decarboxylase activity
B11cv2_RS06305	COG0745	RESPONSE REGULATOR receiver
B11cv2_RS06320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B11cv2_RS06340	COG0351	phosphomethylpyrimidine kinase
B11cv2_RS06350	COG1686	Belongs to the peptidase S11 family
B11cv2_RS06355	COG0523	cobalamin synthesis protein
B11cv2_RS06360	COG3034	peptidoglycan biosynthetic process
B11cv2_RS06365	COG0825	malonyl-CoA metabolic process
B11cv2_RS06385	COG1320	monovalent cation:proton antiporter activity
B11cv2_RS06390	COG2212	antiporter activity
B11cv2_RS06400	COG0651	ATP synthesis coupled electron transport
B11cv2_RS06405	COG1006	Multisubunit Na H antiporter MnhC subunit
B11cv2_RS06410	COG2111	Na H antiporter
B11cv2_RS06410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B11cv2_RS06420	COG0019	diaminopimelate decarboxylase activity
B11cv2_RS06435	COG0508	dehydrogenase complex catalyzes the overall conversion of
B11cv2_RS06440	COG0567	Dehydrogenase, E1 component
B11cv2_RS06445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B11cv2_RS06450	COG0045	succinate-CoA ligase (ADP-forming) activity
B11cv2_RS06455	COG0039	L-malate dehydrogenase activity
B11cv2_RS06460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B11cv2_RS06470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B11cv2_RS06475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B11cv2_RS06480	COG0552	protein localization to endoplasmic reticulum
B11cv2_RS06490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B11cv2_RS06505	COG0357	Ribosomal RNA small subunit methyltransferase G
B11cv2_RS06510	COG0445	tRNA wobble uridine modification
B11cv2_RS06515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B11cv2_RS06520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B11cv2_RS06530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B11cv2_RS06535	COG0424	maF-like protein
B11cv2_RS06540	COG0237	dephospho-CoA kinase activity
B11cv2_RS06550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B11cv2_RS06550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B11cv2_RS06560	COG0670	Belongs to the BI1 family
B11cv2_RS06565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B11cv2_RS06570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B11cv2_RS06575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B11cv2_RS06575	COG0116	Belongs to the methyltransferase superfamily
B11cv2_RS06585	COG0776	regulation of translation
B11cv2_RS06600	COG1137	ATPase activity
B11cv2_RS06605	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B11cv2_RS06615	COG0137	argininosuccinate synthase activity
B11cv2_RS06620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B11cv2_RS06645	COG2887	Belongs to the helicase family. UvrD subfamily
B11cv2_RS06650	COG0802	atpase or kinase
B11cv2_RS06655	COG2205	protein histidine kinase activity
B11cv2_RS06660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B11cv2_RS06670	COG0285	dihydrofolate synthase activity
B11cv2_RS06675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B11cv2_RS06685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B11cv2_RS06690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B11cv2_RS06695	COG2226	methyltransferase
B11cv2_RS06725	COG1132	(ABC) transporter
B11cv2_RS06730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B11cv2_RS06745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B11cv2_RS06750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B11cv2_RS06755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B11cv2_RS06760	COG1420	regulation of RNA biosynthetic process
B11cv2_RS06765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B11cv2_RS06770	COG2205	protein histidine kinase activity
B11cv2_RS06775	COG0745	RESPONSE REGULATOR receiver
B11cv2_RS06790	COG0443	Heat shock 70 kDa protein
B11cv2_RS06795	COG0484	heat shock protein binding
B11cv2_RS06800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B11cv2_RS06810	COG2184	nucleotidyltransferase activity
B11cv2_RS06820	COG2948	multi-organism process
B11cv2_RS06825	COG3504	Conjugal transfer protein
B11cv2_RS06830	COG3736	Type IV secretory pathway, component VirB8
B11cv2_RS06840	COG3704	protein secretion by the type IV secretion system
B11cv2_RS06850	COG3451	type IV secretory pathway VirB4
B11cv2_RS06855	COG3702	type iv secretory pathway
B11cv2_RS06860	COG3838	Conjugal transfer protein Trbc
B11cv2_RS06865	COG2171	N-acyltransferase activity
B11cv2_RS06870	COG0481	GTPase activity
B11cv2_RS06875	COG0101	tRNA pseudouridine synthase activity
B11cv2_RS06880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B11cv2_RS06885	COG0242	peptide deformylase activity
B11cv2_RS06910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B11cv2_RS06915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B11cv2_RS06920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B11cv2_RS06925	COG0072	phenylalanine-tRNA ligase activity
B11cv2_RS06925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B11cv2_RS06935	COG1121	(ABC) transporter
B11cv2_RS06940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B11cv2_RS06945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B11cv2_RS06950	COG2832	Protein of unknown function (DUF454)
B11cv2_RS06955	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B11cv2_RS06960	COG3459	Glycosyltransferase 36 associated
B11cv2_RS06965	COG0539	negative regulation of cytoplasmic translation
B11cv2_RS06970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B11cv2_RS06975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B11cv2_RS06990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B11cv2_RS06995	COG0281	malic enzyme
B11cv2_RS06995	COG0280	phosphate acetyltransferase
B11cv2_RS07000	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B11cv2_RS07020	COG2184	nucleotidyltransferase activity
B11cv2_RS07035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B11cv2_RS07050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B11cv2_RS07055	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B11cv2_RS07060	COG4133	protoheme IX ABC transporter activity
B11cv2_RS07065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B11cv2_RS07070	COG0268	Binds directly to 16S ribosomal RNA