locus-tag	class	description
H3299_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H3299_RS00010	COG2890	protein-(glutamine-N5) methyltransferase activity
H3299_RS00015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H3299_RS00025	COG0488	(ABC) transporter
H3299_RS00030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H3299_RS00065	COG0174	glutamine synthetase
H3299_RS00070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3299_RS00075	COG0519	Catalyzes the synthesis of GMP from XMP
H3299_RS00120	COG0477	Major facilitator Superfamily
H3299_RS00125	COG0028	Belongs to the TPP enzyme family
H3299_RS00135	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H3299_RS00155	COG3852	Histidine kinase
H3299_RS00165	COG0604	alcohol dehydrogenase
H3299_RS00185	COG3842	ATPase activity
H3299_RS00190	COG1178	ABC-type Fe3 transport system permease component
H3299_RS00225	COG0640	Transcriptional regulator
H3299_RS00235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H3299_RS00240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H3299_RS00245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H3299_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H3299_RS00305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H3299_RS00310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H3299_RS00325	COG3750	Belongs to the UPF0335 family
H3299_RS00350	COG0683	leucine binding
H3299_RS00370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H3299_RS00375	COG0697	spore germination
H3299_RS00390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H3299_RS00400	COG1132	(ABC) transporter
H3299_RS00405	COG0285	dihydrofolate synthase activity
H3299_RS00415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H3299_RS00430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H3299_RS00455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H3299_RS00460	COG0527	aspartate kinase activity
H3299_RS00475	COG1136	(ABC) transporter
H3299_RS00475	COG0577	efflux transmembrane transporter activity
H3299_RS00480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H3299_RS00495	COG1519	Transferase
H3299_RS00500	COG1663	tetraacyldisaccharide 4'-kinase activity
H3299_RS00505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H3299_RS00510	COG0602	queuosine metabolic process
H3299_RS00515	COG0720	synthase
H3299_RS00550	COG0277	FAD linked oxidase domain protein
H3299_RS00560	COG3842	ATPase activity
H3299_RS00565	COG1176	ABC-type spermidine putrescine transport system, permease component I
H3299_RS00570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3299_RS00580	COG1304	FMN binding
H3299_RS00635	COG0484	heat shock protein binding
H3299_RS00640	COG0443	Heat shock 70 kDa protein
H3299_RS00645	COG1473	amidohydrolase
H3299_RS00660	COG2951	lytic endotransglycosylase activity
H3299_RS00670	COG2358	TRAP transporter, solute receptor (TAXI family
H3299_RS00680	COG1116	anion transmembrane transporter activity
H3299_RS00690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H3299_RS00700	COG3266	domain, Protein
H3299_RS00700	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H3299_RS00700	COG4932	domain protein
H3299_RS00705	COG2902	Dehydrogenase
H3299_RS00710	COG0288	reversible hydration of carbon dioxide
H3299_RS00715	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H3299_RS00740	COG1012	belongs to the aldehyde dehydrogenase family
H3299_RS00750	COG2086	electron transfer activity
H3299_RS00775	COG1177	transmembrane transport
H3299_RS00785	COG3842	ATPase activity
H3299_RS00790	COG1074	ATP-dependent DNA helicase activity
H3299_RS00795	COG2887	Belongs to the helicase family. UvrD subfamily
H3299_RS00800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H3299_RS00805	COG2813	Specifically methylates the guanine in position
H3299_RS00810	COG1473	amidohydrolase
H3299_RS00840	COG2072	flavoprotein involved in K transport
H3299_RS00860	COG0583	DNA-binding transcription factor activity
H3299_RS00870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3299_RS00875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H3299_RS00880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H3299_RS00885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H3299_RS00900	COG0730	response to heat
H3299_RS00910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H3299_RS00920	COG0259	pyridoxamine-phosphate oxidase activity
H3299_RS00925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H3299_RS00975	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H3299_RS00980	COG3030	protein affecting phage T7 exclusion by the F plasmid
H3299_RS00990	COG1175	transmembrane transport
H3299_RS00995	COG0395	ABC-type sugar transport system, permease component
H3299_RS01000	COG3842	ATPase activity
H3299_RS01015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H3299_RS01045	COG3588	fructose-bisphosphate aldolase
H3299_RS01060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H3299_RS01065	COG1137	ATPase activity
H3299_RS01080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H3299_RS01105	COG1301	dicarboxylic acid transport
H3299_RS01115	COG0667	Aldo Keto reductase
H3299_RS01120	COG2011	ABC-type metal ion transport system permease component
H3299_RS01125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H3299_RS01170	COG0339	signal peptide processing
H3299_RS01175	COG2239	Acts as a magnesium transporter
H3299_RS01190	COG0469	pyruvate kinase activity
H3299_RS01200	COG0672	)-iron permease
H3299_RS01225	COG1250	3-hydroxyacyl-CoA dehydrogenase
H3299_RS01235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H3299_RS01245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H3299_RS01265	COG1172	Belongs to the binding-protein-dependent transport system permease family
H3299_RS01285	COG0582	viral genome integration into host DNA
H3299_RS01310	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H3299_RS01315	COG3421	Type III restriction
H3299_RS01330	COG0784	Response regulator, receiver
H3299_RS01345	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H3299_RS01350	COG2202	Pas domain
H3299_RS01350	COG3920	Histidine kinase
H3299_RS01365	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H3299_RS01390	COG1760	l-serine dehydratase
H3299_RS01400	COG0033	Phosphoglucomutase
H3299_RS01405	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H3299_RS01420	COG0019	diaminopimelate decarboxylase activity
H3299_RS01425	COG3257	ureidoglycine aminohydrolase activity
H3299_RS01430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H3299_RS01450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3299_RS01460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3299_RS01465	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H3299_RS01490	COG1063	alcohol dehydrogenase
H3299_RS01500	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H3299_RS01510	COG0248	Ppx GppA phosphatase
H3299_RS01550	COG0644	oxidoreductase
H3299_RS01555	COG0644	oxidoreductase
H3299_RS01560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H3299_RS01560	COG0425	Belongs to the sulfur carrier protein TusA family
H3299_RS01570	COG3034	peptidoglycan biosynthetic process
H3299_RS01590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H3299_RS01595	COG0037	tRNA processing
H3299_RS01605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H3299_RS01625	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H3299_RS01630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H3299_RS01635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H3299_RS01640	COG1845	cytochrome c oxidase, subunit III
H3299_RS01645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H3299_RS01650	COG1620	l-lactate permease
H3299_RS01655	COG2186	Transcriptional regulator
H3299_RS01660	COG1304	FMN binding
H3299_RS01680	COG1218	3'(2'),5'-bisphosphate nucleotidase
H3299_RS01685	COG2226	methyltransferase
H3299_RS01690	COG1040	competence protein
H3299_RS01695	COG0792	nuclease activity
H3299_RS01700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H3299_RS01705	COG0436	Aminotransferase
H3299_RS01720	COG1120	ATPase activity
H3299_RS01755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H3299_RS01755	COG2111	Na H antiporter
H3299_RS01760	COG1006	Multisubunit Na H antiporter MnhC subunit
H3299_RS01765	COG0651	ATP synthesis coupled electron transport
H3299_RS01770	COG1863	multisubunit Na H antiporter MnhE subunit
H3299_RS01775	COG2212	antiporter activity
H3299_RS01780	COG1320	monovalent cation:proton antiporter activity
H3299_RS01785	COG1376	ErfK ybiS ycfS ynhG family protein
H3299_RS01795	COG0471	metal ion transport
H3299_RS01800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H3299_RS01805	COG0583	DNA-binding transcription factor activity
H3299_RS01815	COG1970	mechanosensitive ion channel activity
H3299_RS01825	COG0754	glutathionylspermidine amidase activity
H3299_RS01830	COG5463	Belongs to the UPF0441 family
H3299_RS01835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H3299_RS01840	COG1702	phosphate starvation-inducible protein PhoH
H3299_RS01850	COG4535	Mg2 and Co2 transporter CorC
H3299_RS01855	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H3299_RS01860	COG1396	sequence-specific DNA binding
H3299_RS01865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H3299_RS01885	COG0802	atpase or kinase
H3299_RS01890	COG2205	protein histidine kinase activity
H3299_RS01915	COG0110	maltose O-acetyltransferase activity
H3299_RS01930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H3299_RS01955	COG0670	Belongs to the BI1 family
H3299_RS01960	COG4181	ATPase activity
H3299_RS01995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H3299_RS02045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H3299_RS02050	COG0351	phosphomethylpyrimidine kinase
H3299_RS02060	COG0477	Major facilitator Superfamily
H3299_RS02065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H3299_RS02085	COG0181	hydroxymethylbilane synthase activity
H3299_RS02090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H3299_RS02110	COG2271	Major facilitator Superfamily
H3299_RS02115	COG0697	spore germination
H3299_RS02120	COG2186	Transcriptional regulator
H3299_RS02125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3299_RS02130	COG1012	belongs to the aldehyde dehydrogenase family
H3299_RS02150	COG0305	Participates in initiation and elongation during chromosome replication
H3299_RS02185	COG3477	response to acidic pH
H3299_RS02200	COG2885	chlorophyll binding
H3299_RS02205	COG4974	Belongs to the 'phage' integrase family
H3299_RS02220	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H3299_RS02240	COG2840	Smr protein MutS2
H3299_RS02250	COG0159	tryptophan synthase activity
H3299_RS02270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3299_RS02290	COG0151	Belongs to the GarS family
H3299_RS02295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3299_RS02315	COG2884	Cell division ATP-binding protein ftsE
H3299_RS02330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H3299_RS02340	COG1522	sequence-specific DNA binding
H3299_RS02350	COG1136	(ABC) transporter
H3299_RS02360	COG1785	Belongs to the alkaline phosphatase family
H3299_RS02365	COG2252	PERMEase
H3299_RS02370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H3299_RS02380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H3299_RS02385	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
H3299_RS02405	COG3118	belongs to the thioredoxin family
H3299_RS02435	COG0590	tRNA wobble adenosine to inosine editing
H3299_RS02445	COG0471	metal ion transport
H3299_RS02470	COG0583	DNA-binding transcription factor activity
H3299_RS02505	COG2086	electron transfer activity
H3299_RS02520	COG3443	Belongs to the bacterial solute-binding protein 9 family
H3299_RS02535	COG0589	response to stress
H3299_RS02540	COG1686	Belongs to the peptidase S11 family
H3299_RS02550	COG0066	3-isopropylmalate dehydratase activity
H3299_RS02565	COG1063	alcohol dehydrogenase
H3299_RS02580	COG0824	Thioesterase
H3299_RS02590	COG0632	four-way junction helicase activity
H3299_RS02600	COG2720	vancomycin resistance protein
H3299_RS02630	COG0456	acetyltransferase
H3299_RS02635	COG1214	PFAM Peptidase M22, glycoprotease
H3299_RS02645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3299_RS02655	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H3299_RS02660	COG0642	Histidine kinase
H3299_RS02665	COG0745	RESPONSE REGULATOR receiver
H3299_RS02695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H3299_RS02710	COG0523	cobalamin synthesis protein
H3299_RS02715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H3299_RS02725	COG2205	protein histidine kinase activity
H3299_RS02730	COG2084	Dehydrogenase
H3299_RS02735	COG4771	TonB-dependent receptor
H3299_RS02740	COG2819	hydrolase of the alpha beta superfamily
H3299_RS02745	COG4607	ABC-type enterochelin transport system periplasmic component
H3299_RS02750	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3299_RS02755	COG4605	iron ion homeostasis
H3299_RS02760	COG4604	ABC transporter, ATP-binding protein
H3299_RS02785	COG0697	spore germination
H3299_RS02810	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H3299_RS02840	COG1309	transcriptional regulator
H3299_RS02865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H3299_RS02875	COG3158	transport of potassium into the cell
H3299_RS02890	COG2226	methyltransferase
H3299_RS02900	COG3047	cAMP biosynthetic process
H3299_RS02915	COG3273	potassium ion transport
H3299_RS02915	COG0471	metal ion transport
H3299_RS02930	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H3299_RS02940	COG4149	molybdate abc transporter
H3299_RS02945	COG0157	Belongs to the NadC ModD family
H3299_RS02965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H3299_RS02975	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H3299_RS02985	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H3299_RS02995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H3299_RS03000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H3299_RS03000	COG2813	Specifically methylates the guanine in position
H3299_RS03030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H3299_RS03055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H3299_RS03065	COG0131	Imidazoleglycerol-phosphate dehydratase
H3299_RS03075	COG5002	protein histidine kinase activity
H3299_RS03080	COG2326	polyphosphate kinase activity
H3299_RS03085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3299_RS03090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H3299_RS03100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H3299_RS03120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H3299_RS03160	COG2268	Band 7 protein
H3299_RS03175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H3299_RS03180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H3299_RS03180	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H3299_RS03190	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H3299_RS03205	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H3299_RS03225	COG3654	unkown
H3299_RS03230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H3299_RS03235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H3299_RS03270	COG3738	Protein conserved in bacteria
H3299_RS03275	COG0735	belongs to the Fur family
H3299_RS03290	COG1733	regulation of RNA biosynthetic process
H3299_RS03295	COG2910	NAD(P)H-binding
H3299_RS03300	COG1846	Transcriptional regulator
H3299_RS03310	COG0523	cobalamin synthesis protein
H3299_RS03320	COG1902	pentaerythritol trinitrate reductase activity
H3299_RS03325	COG2183	response to ionizing radiation
H3299_RS03350	COG1525	nuclease
H3299_RS03355	COG1132	(ABC) transporter
H3299_RS03365	COG0546	phosphoglycolate phosphatase activity
H3299_RS03385	COG2095	MarC family integral membrane protein
H3299_RS03400	COG4774	siderophore transport
H3299_RS03405	COG2207	Transcriptional regulator
H3299_RS03410	COG1120	ATPase activity
H3299_RS03415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H3299_RS03420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H3299_RS03435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H3299_RS03440	COG0343	queuine tRNA-ribosyltransferase activity
H3299_RS03455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3299_RS03535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H3299_RS03555	COG0142	geranyltranstransferase activity
H3299_RS03570	COG0751	glycine-tRNA ligase activity
H3299_RS03575	COG0823	Involved in the tonB-independent uptake of proteins
H3299_RS03575	COG1506	peptidase
H3299_RS03580	COG2847	Copper chaperone PCu(A)C
H3299_RS03590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H3299_RS03610	COG0681	Belongs to the peptidase S26 family
H3299_RS03625	COG0521	Mo-molybdopterin cofactor biosynthetic process
H3299_RS03635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H3299_RS03640	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H3299_RS03645	COG0535	radical SAM domain protein
H3299_RS03650	COG0535	radical SAM domain protein
H3299_RS03655	COG0163	prenyltransferase activity
H3299_RS03660	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H3299_RS03665	COG3154	lipid carrier protein
H3299_RS03670	COG0826	peptidase U32
H3299_RS03685	COG4993	Dehydrogenase
H3299_RS03715	COG0714	Associated with various cellular activities
H3299_RS03740	COG0494	nUDIX hydrolase
H3299_RS03745	COG0740	serine-type endopeptidase activity
H3299_RS03750	COG3152	Membrane
H3299_RS03765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H3299_RS03780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3299_RS03785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H3299_RS03805	COG3023	N-Acetylmuramoyl-L-alanine amidase
H3299_RS03810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H3299_RS03840	COG0625	glutathione transferase activity
H3299_RS03850	COG3852	Histidine kinase
H3299_RS03855	COG2204	response regulator
H3299_RS03860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H3299_RS03870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H3299_RS03885	COG0081	regulation of translation
H3299_RS03895	COG0222	ribosome binding
H3299_RS03905	COG0085	RNA polymerase activity
H3299_RS03910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H3299_RS03930	COG2205	protein histidine kinase activity
H3299_RS03930	COG2202	Pas domain
H3299_RS03940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H3299_RS03940	COG0519	Catalyzes the synthesis of GMP from XMP
H3299_RS03955	COG0433	COG0433 Predicted ATPase
H3299_RS03975	COG1653	transport
H3299_RS03980	COG0395	ABC-type sugar transport system, permease component
H3299_RS03985	COG1175	transmembrane transport
H3299_RS03990	COG3842	ATPase activity
H3299_RS03995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H3299_RS04000	COG1966	Carbon starvation protein
H3299_RS04005	COG2879	small protein
H3299_RS04010	COG0523	cobalamin synthesis protein
H3299_RS04020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H3299_RS04025	COG1780	Probably involved in ribonucleotide reductase function
H3299_RS04030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H3299_RS04040	COG1758	RNA polymerase activity
H3299_RS04055	COG2223	nitrite transmembrane transporter activity
H3299_RS04060	COG0741	lytic transglycosylase activity
H3299_RS04075	COG0251	oxidation-reduction process
H3299_RS04090	COG0431	NADPH-dependent FMN reductase
H3299_RS04115	COG0556	nucleotide-excision repair
H3299_RS04120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H3299_RS04140	COG2195	Cleaves the N-terminal amino acid of tripeptides
H3299_RS04145	COG0747	negative chemotaxis
H3299_RS04155	COG0667	Aldo Keto reductase
H3299_RS04160	COG0789	Transcriptional regulator
H3299_RS04170	COG1194	a g-specific adenine glycosylase
H3299_RS04175	COG0187	DNA topoisomerase II activity
H3299_RS04180	COG0321	lipoyl(octanoyl) transferase activity
H3299_RS04190	COG0194	GDP metabolic process
H3299_RS04195	COG1492	cobalamin metabolic process
H3299_RS04200	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H3299_RS04215	COG1278	Cold shock
H3299_RS04225	COG1678	Uncharacterized ACR, COG1678
H3299_RS04245	COG0745	RESPONSE REGULATOR receiver
H3299_RS04270	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3299_RS04285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3299_RS04295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H3299_RS04300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H3299_RS04305	COG1183	phosphatidylcholine synthase activity
H3299_RS04315	COG1686	Belongs to the peptidase S11 family
H3299_RS04330	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3299_RS04335	COG0084	hydrolase, TatD family'
H3299_RS04340	COG0321	lipoyl(octanoyl) transferase activity
H3299_RS04340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H3299_RS04345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H3299_RS04385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H3299_RS04390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3299_RS04395	COG0544	peptidyl-prolyl cis-trans isomerase activity
H3299_RS04415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H3299_RS04425	COG0312	modulator of DNA gyrase
H3299_RS04440	COG0513	Belongs to the DEAD box helicase family
H3299_RS04445	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H3299_RS04465	COG4957	zinc ion binding
H3299_RS04470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3299_RS04475	COG1132	(ABC) transporter
H3299_RS04480	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H3299_RS04500	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H3299_RS04505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H3299_RS04515	COG3720	iron ion transport
H3299_RS04535	COG4178	(ABC) transporter
H3299_RS04560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H3299_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
H3299_RS04570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H3299_RS04590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H3299_RS04595	COG0360	Binds together with S18 to 16S ribosomal RNA
H3299_RS04600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H3299_RS04600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H3299_RS04605	COG0347	Belongs to the P(II) protein family
H3299_RS04610	COG0174	glutamine synthetase
H3299_RS04630	COG1530	ribonuclease E activity
H3299_RS04635	COG0860	N-Acetylmuramoyl-L-alanine amidase
H3299_RS04640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H3299_RS04655	COG0785	Cytochrome C biogenesis protein
H3299_RS04660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H3299_RS04670	COG1722	exodeoxyribonuclease VII activity
H3299_RS04675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3299_RS04675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3299_RS04695	COG0024	Methionine aminopeptidase
H3299_RS04715	COG1278	Cold shock
H3299_RS04745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H3299_RS04805	COG0483	inositol monophosphate 1-phosphatase activity
H3299_RS04815	COG0071	Belongs to the small heat shock protein (HSP20) family
H3299_RS04825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H3299_RS04830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H3299_RS04830	COG0512	Glutamine amidotransferase of anthranilate synthase
H3299_RS04840	COG1278	Cold shock
H3299_RS04860	COG1494	fructose-1,6-bisphosphatase
H3299_RS04870	COG0436	Aminotransferase
H3299_RS04895	COG0758	DNA mediated transformation
H3299_RS04905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H3299_RS04905	COG1754	DNA topoisomerase type I activity
H3299_RS04910	COG0557	exoribonuclease II activity
H3299_RS04915	COG0477	Major facilitator Superfamily
H3299_RS04920	COG0277	FAD linked oxidase domain protein
H3299_RS04925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H3299_RS04930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H3299_RS04935	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H3299_RS04940	COG0356	it plays a direct role in the translocation of protons across the membrane
H3299_RS04955	COG1160	GTP binding
H3299_RS04965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H3299_RS04975	COG0243	molybdopterin cofactor binding
H3299_RS04985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H3299_RS04990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H3299_RS04995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H3299_RS05000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H3299_RS05005	COG0805	protein transport
H3299_RS05015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H3299_RS05020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H3299_RS05025	COG4942	peptidase
H3299_RS05025	COG1388	LysM domain
H3299_RS05030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H3299_RS05035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H3299_RS05040	COG0314	molybdopterin synthase activity
H3299_RS05055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H3299_RS05065	COG0105	UTP biosynthetic process
H3299_RS05070	COG0488	(ABC) transporter
H3299_RS05075	COG3676	manually curated
H3299_RS05085	COG2151	metal-sulfur cluster biosynthetic enzyme
H3299_RS05090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H3299_RS05095	COG0719	Fe-S assembly protein
H3299_RS05100	COG0396	ATPase activity
H3299_RS05105	COG0719	Fe-S assembly protein
H3299_RS05110	COG1104	cysteine desulfurase activity
H3299_RS05115	COG2945	thiolester hydrolase activity
H3299_RS05130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H3299_RS05135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H3299_RS05155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H3299_RS05160	COG2274	protein secretion by the type I secretion system
H3299_RS05175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H3299_RS05180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H3299_RS05185	COG0022	dehydrogenase e1 component
H3299_RS05185	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3299_RS05190	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3299_RS05195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3299_RS05200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H3299_RS05205	COG2867	negative regulation of translational initiation
H3299_RS05210	COG0538	isocitrate dehydrogenase activity
H3299_RS05240	COG2204	response regulator
H3299_RS05255	COG1585	Membrane protein implicated in regulation of membrane protease activity
H3299_RS05260	COG0330	HflC and HflK could
H3299_RS05265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H3299_RS05280	COG0303	'Molybdopterin
H3299_RS05285	COG0315	cyclic pyranopterin monophosphate synthase activity
H3299_RS05290	COG0134	indole-3-glycerol-phosphate synthase activity
H3299_RS05295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H3299_RS05310	COG2099	Precorrin-6x reductase
H3299_RS05335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H3299_RS05340	COG0109	protoheme IX farnesyltransferase activity
H3299_RS05350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H3299_RS05355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H3299_RS05365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3299_RS05380	COG2828	Protein conserved in bacteria
H3299_RS05385	COG0583	DNA-binding transcription factor activity
H3299_RS05395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H3299_RS05400	COG0052	Belongs to the universal ribosomal protein uS2 family
H3299_RS05415	COG0740	serine-type endopeptidase activity
H3299_RS05425	COG0569	domain protein
H3299_RS05430	COG2204	response regulator
H3299_RS05435	COG5000	phosphorelay sensor kinase activity
H3299_RS05440	COG1959	2 iron, 2 sulfur cluster binding
H3299_RS05445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H3299_RS05445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H3299_RS05450	COG1546	Belongs to the CinA family
H3299_RS05450	COG1058	Belongs to the CinA family
H3299_RS05465	COG4585	Histidine kinase
H3299_RS05470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H3299_RS05480	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H3299_RS05490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H3299_RS05495	COG0215	cysteine-tRNA ligase activity
H3299_RS05505	COG1028	Short-chain dehydrogenase reductase Sdr
H3299_RS05515	COG1764	response to oxidative stress
H3299_RS05520	COG0308	aminopeptidase N
H3299_RS05530	COG1573	uracil-dna glycosylase
H3299_RS05535	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H3299_RS05550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3299_RS05585	COG0596	Alpha beta hydrolase
H3299_RS05595	COG3189	MarR family transcriptional regulator
H3299_RS05605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H3299_RS05620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H3299_RS05635	COG3835	regulator
H3299_RS05640	COG1126	abc transporter atp-binding protein
H3299_RS05645	COG0765	amino acid transport
H3299_RS05650	COG4597	amino acid ABC transporter
H3299_RS05655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3299_RS05660	COG0626	cystathionine gamma-synthase activity
H3299_RS05670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H3299_RS05695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H3299_RS05695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H3299_RS05705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H3299_RS05725	COG0372	Belongs to the citrate synthase family
H3299_RS05755	COG0024	Methionine aminopeptidase
H3299_RS05760	COG1489	DNA binding
H3299_RS05765	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H3299_RS05770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H3299_RS05780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H3299_RS05785	COG2181	nitrate reductase activity
H3299_RS05790	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H3299_RS05795	COG1140	nitrate reductase beta subunit
H3299_RS05800	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H3299_RS05805	COG2223	nitrite transmembrane transporter activity
H3299_RS05835	COG0633	Ferredoxin
H3299_RS05850	COG1797	cobyrinic acid a,c-diamide synthase activity
H3299_RS05855	COG2814	Major facilitator Superfamily
H3299_RS05875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3299_RS05880	COG0745	RESPONSE REGULATOR receiver
H3299_RS05890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H3299_RS05895	COG0531	amino acid
H3299_RS05905	COG1612	heme a metabolic process
H3299_RS05910	COG0113	porphobilinogen synthase activity
H3299_RS05925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H3299_RS05930	COG0037	tRNA processing
H3299_RS05935	COG1113	amino acid transport
H3299_RS05955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H3299_RS05960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H3299_RS05965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H3299_RS05970	COG0546	phosphoglycolate phosphatase activity
H3299_RS05980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H3299_RS05990	COG4166	transmembrane transport
H3299_RS06000	COG2885	chlorophyll binding
H3299_RS06005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H3299_RS06010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H3299_RS06045	COG1522	sequence-specific DNA binding
H3299_RS06060	COG0728	peptidoglycan biosynthetic process
H3299_RS06085	COG0436	Aminotransferase
H3299_RS06090	COG0501	Belongs to the peptidase M48B family
H3299_RS06100	COG0511	ligase activity, forming carbon-carbon bonds
H3299_RS06110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H3299_RS06120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H3299_RS06125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H3299_RS06130	COG0149	triose-phosphate isomerase activity
H3299_RS06140	COG3381	protein complex oligomerization
H3299_RS06145	COG2010	Cytochrome c
H3299_RS06155	COG0528	UMP kinase activity
H3299_RS06160	COG0233	cytoplasmic translational termination
H3299_RS06180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H3299_RS06185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H3299_RS06195	COG2226	methyltransferase
H3299_RS06210	COG2610	gluconate transmembrane transporter activity
H3299_RS06215	COG3265	gluconokinase activity
H3299_RS06220	COG0180	Tryptophanyl-tRNA synthetase
H3299_RS06225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H3299_RS06225	COG3218	ABC-type transport auxiliary lipoprotein component
H3299_RS06235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H3299_RS06235	COG3218	ABC-type transport auxiliary lipoprotein component
H3299_RS06245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H3299_RS06255	COG0280	phosphate acetyltransferase
H3299_RS06255	COG0281	malic enzyme
H3299_RS06260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3299_RS06265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3299_RS06270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3299_RS06285	COG2875	Belongs to the precorrin methyltransferase family
H3299_RS06310	COG1862	Preprotein translocase
H3299_RS06320	COG0746	molybdenum cofactor guanylyltransferase activity
H3299_RS06330	COG0625	glutathione transferase activity
H3299_RS06340	COG1573	uracil-dna glycosylase
H3299_RS06350	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H3299_RS06360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3299_RS06370	COG0765	amino acid transport
H3299_RS06375	COG0765	amino acid transport
H3299_RS06380	COG1126	abc transporter atp-binding protein
H3299_RS06385	COG3938	Belongs to the proline racemase family
H3299_RS06400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3299_RS06405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3299_RS06430	COG3106	COG3106 Predicted ATPase
H3299_RS06435	COG0316	Belongs to the HesB IscA family
H3299_RS06450	COG1686	Belongs to the peptidase S11 family
H3299_RS06470	COG0277	FAD linked oxidase domain protein
H3299_RS06480	COG2897	thiosulfate sulfurtransferase activity
H3299_RS06515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H3299_RS06525	COG1957	nucleoside hydrolase
H3299_RS06530	COG0477	Major facilitator Superfamily
H3299_RS06565	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H3299_RS06575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H3299_RS06585	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H3299_RS06595	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H3299_RS06600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H3299_RS06605	COG0750	zinc metalloprotease
H3299_RS06625	COG0316	Belongs to the HesB IscA family
H3299_RS06635	COG3180	Ammonia monooxygenase
H3299_RS06640	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H3299_RS06670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H3299_RS06675	COG0537	adenosine 5'-monophosphoramidase activity
H3299_RS06680	COG1126	abc transporter atp-binding protein
H3299_RS06695	COG0442	prolyl-tRNA aminoacylation
H3299_RS06710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H3299_RS06720	COG0628	permease
H3299_RS06725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H3299_RS06730	COG0612	Peptidase, M16
H3299_RS06740	COG0196	riboflavin kinase activity
H3299_RS06745	COG3577	Aspartyl protease
H3299_RS06750	COG3088	subunit of a heme lyase
H3299_RS06755	COG1138	Cytochrome C-type biogenesis protein
H3299_RS06760	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H3299_RS06775	COG1064	alcohol dehydrogenase
H3299_RS06785	COG2989	Protein conserved in bacteria
H3299_RS06795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3299_RS06800	COG2205	protein histidine kinase activity
H3299_RS06805	COG0745	RESPONSE REGULATOR receiver
H3299_RS06855	COG2855	membrane
H3299_RS06870	COG0200	Binds to the 23S rRNA
H3299_RS06880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H3299_RS06890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H3299_RS06900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H3299_RS06910	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H3299_RS06915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H3299_RS06930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H3299_RS06945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H3299_RS06960	COG0088	Forms part of the polypeptide exit tunnel
H3299_RS06965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H3299_RS06975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H3299_RS06990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H3299_RS07010	COG0765	amino acid transport
H3299_RS07015	COG0765	amino acid transport
H3299_RS07020	COG1126	abc transporter atp-binding protein
H3299_RS07035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3299_RS07050	COG1012	belongs to the aldehyde dehydrogenase family
H3299_RS07055	COG3108	Peptidase M15
H3299_RS07070	COG3676	manually curated
H3299_RS07075	COG1196	nuclear chromosome segregation
H3299_RS07085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H3299_RS07115	COG0067	glutamate synthase
H3299_RS07115	COG0069	glutamate synthase activity
H3299_RS07115	COG0070	glutamate synthase
H3299_RS07120	COG0025	NhaP-type Na H and K H
H3299_RS07130	COG2166	iron-sulfur cluster assembly
H3299_RS07160	COG2895	sulfate adenylyltransferase (ATP) activity
H3299_RS07170	COG0175	sulfate reduction
H3299_RS07185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H3299_RS07205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H3299_RS07235	COG3956	TIGRFAM MazG family protein
H3299_RS07240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H3299_RS07250	COG1253	flavin adenine dinucleotide binding
H3299_RS07265	COG0617	tRNA 3'-terminal CCA addition
H3299_RS07270	COG0494	nUDIX hydrolase
H3299_RS07275	COG0714	Associated with various cellular activities
H3299_RS07300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H3299_RS07305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H3299_RS07330	COG2814	Major facilitator Superfamily
H3299_RS07335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H3299_RS07365	COG0420	3'-5' exonuclease activity
H3299_RS07370	COG4717	serine-type aminopeptidase activity
H3299_RS07375	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H3299_RS07395	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H3299_RS07410	COG2205	protein histidine kinase activity
H3299_RS07425	COG1309	transcriptional regulator
H3299_RS07550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H3299_RS07560	COG1832	CoA-binding protein
H3299_RS07565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H3299_RS07570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H3299_RS07580	COG1346	cytolysis
H3299_RS07585	COG1380	Effector of murein hydrolase LrgA
H3299_RS07590	COG0583	DNA-binding transcription factor activity
H3299_RS07605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H3299_RS07610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H3299_RS07615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H3299_RS07625	COG0784	Response regulator, receiver
H3299_RS07630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H3299_RS07655	COG0202	RNA polymerase activity
H3299_RS07665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H3299_RS07670	COG0563	adenylate kinase activity
H3299_RS07675	COG0201	protein transport
H3299_RS07680	COG0513	Belongs to the DEAD box helicase family
H3299_RS07690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H3299_RS07920	COG3179	chitinase
H3299_RS07995	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H3299_RS07995	COG3264	Mechanosensitive ion channel
H3299_RS08010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H3299_RS08010	COG4651	solute:proton antiporter activity
H3299_RS08035	COG0776	regulation of translation
H3299_RS08040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3299_RS08070	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H3299_RS08075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H3299_RS08090	COG2239	Acts as a magnesium transporter
H3299_RS08105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H3299_RS08120	COG1183	phosphatidylcholine synthase activity
H3299_RS08125	COG0688	phosphatidylethanolamine metabolic process
H3299_RS08130	COG5265	(ABC) transporter
H3299_RS08135	COG1652	LysM domain
H3299_RS08135	COG2823	Periplasmic or secreted lipoprotein
H3299_RS08140	COG1611	Belongs to the LOG family
H3299_RS08150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3299_RS08165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H3299_RS08175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3299_RS08185	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H3299_RS08235	COG0504	CTP synthase activity
H3299_RS08245	COG0148	phosphopyruvate hydratase activity
H3299_RS08250	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H3299_RS08260	COG1121	(ABC) transporter
H3299_RS08265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3299_RS08270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3299_RS08275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H3299_RS08300	COG1252	NADH dehydrogenase
H3299_RS08305	COG2378	regulation of single-species biofilm formation
H3299_RS08325	COG2207	Transcriptional regulator
H3299_RS08335	COG1007	ATP synthesis coupled electron transport
H3299_RS08350	COG0713	ATP synthesis coupled electron transport
H3299_RS08360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3299_RS08365	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H3299_RS08375	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H3299_RS08380	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H3299_RS08385	COG0649	NAD binding
H3299_RS08400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3299_RS08405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H3299_RS08435	COG1058	Belongs to the CinA family
H3299_RS08435	COG1546	Belongs to the CinA family
H3299_RS08510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H3299_RS08515	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H3299_RS08520	COG3421	Type III restriction
H3299_RS08540	COG1401	restriction endodeoxyribonuclease activity
H3299_RS08580	COG1074	ATP-dependent DNA helicase activity
H3299_RS08595	COG1396	sequence-specific DNA binding
H3299_RS08640	COG3501	Rhs element vgr protein
H3299_RS08645	COG3501	Rhs element vgr protein
H3299_RS08660	COG3676	manually curated
H3299_RS08675	COG0659	secondary active sulfate transmembrane transporter activity
H3299_RS08680	COG4650	regulator
H3299_RS08695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H3299_RS08705	COG4208	sulfate ABC transporter
H3299_RS08710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H3299_RS08720	COG2252	PERMEase
H3299_RS08735	COG1073	alpha beta
H3299_RS08765	COG0625	glutathione transferase activity
H3299_RS08780	COG4783	chaperone-mediated protein folding
H3299_RS08795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H3299_RS08815	COG0384	phenazine biosynthesis protein PhzF
H3299_RS08825	COG1230	cation diffusion facilitator family transporter
H3299_RS08840	COG0242	peptide deformylase activity
H3299_RS08860	COG2391	methyltransferase activity
H3299_RS08890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3299_RS08895	COG1704	LemA family
H3299_RS08940	COG0489	protein tyrosine kinase activity
H3299_RS08960	COG2423	ornithine cyclodeaminase activity
H3299_RS08975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3299_RS08995	COG4187	Peptidase family M20/M25/M40
H3299_RS09000	COG1643	Atp-dependent helicase
H3299_RS09030	COG0574	Belongs to the PEP-utilizing enzyme family
H3299_RS09030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3299_RS09040	COG0583	DNA-binding transcription factor activity
H3299_RS09055	COG4175	Glycine betaine
H3299_RS09055	COG3448	diguanylate cyclase activity
H3299_RS09075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H3299_RS09100	COG0440	acetolactate synthase activity
H3299_RS09110	COG2382	esterase
H3299_RS09115	COG4774	siderophore transport
H3299_RS09180	COG0028	Belongs to the TPP enzyme family
H3299_RS09190	COG1999	signal sequence binding
H3299_RS09200	COG0006	proline dipeptidase activity
H3299_RS09205	COG0009	L-threonylcarbamoyladenylate synthase
H3299_RS09210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H3299_RS09235	COG1376	ErfK ybiS ycfS ynhG family protein
H3299_RS09240	COG1181	Belongs to the D-alanine--D-alanine ligase family
H3299_RS09250	COG0849	cell division
H3299_RS09265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H3299_RS09265	COG1648	precorrin-2 dehydrogenase activity
H3299_RS09275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H3299_RS09315	COG0753	catalase activity
H3299_RS09325	COG1570	exodeoxyribonuclease VII activity
H3299_RS09330	COG0519	Catalyzes the synthesis of GMP from XMP
H3299_RS09335	COG0004	ammonium transporteR
H3299_RS09340	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H3299_RS09350	COG1522	sequence-specific DNA binding
H3299_RS09370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H3299_RS09380	COG0195	Participates in both transcription termination and antitermination
H3299_RS09380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H3299_RS09385	COG0779	Required for maturation of 30S ribosomal subunits
H3299_RS09400	COG0330	HflC and HflK could
H3299_RS09405	COG0330	HflC and HflK could
H3299_RS09410	COG0210	DNA helicase
H3299_RS09420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H3299_RS09425	COG0277	FAD linked oxidase domain protein
H3299_RS09440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H3299_RS09445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H3299_RS09450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H3299_RS09460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H3299_RS09465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H3299_RS09475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H3299_RS09490	COG0275	rRNA processing
H3299_RS09495	COG3676	manually curated
H3299_RS09540	COG3501	Rhs element vgr protein
H3299_RS09555	COG3676	manually curated
H3299_RS09595	COG3501	Rhs element vgr protein
H3299_RS09615	COG2814	Major facilitator Superfamily
H3299_RS09630	COG1846	Transcriptional regulator
H3299_RS09680	COG1785	Belongs to the alkaline phosphatase family
H3299_RS09695	COG2824	Alkylphosphonate utilization operon protein PhnA
H3299_RS09715	COG0505	Belongs to the CarA family
H3299_RS09720	COG1304	FMN binding
H3299_RS09725	COG0789	Transcriptional regulator
H3299_RS09730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H3299_RS09740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H3299_RS09745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H3299_RS09750	COG0747	negative chemotaxis
H3299_RS09755	COG0747	negative chemotaxis
H3299_RS09765	COG1388	LysM domain
H3299_RS09765	COG1376	ErfK ybiS ycfS ynhG family protein
H3299_RS09780	COG0351	phosphomethylpyrimidine kinase
H3299_RS09790	COG2022	thiamine diphosphate biosynthetic process
H3299_RS09810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H3299_RS09830	COG2171	N-acyltransferase activity
H3299_RS09840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H3299_RS09840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H3299_RS09845	COG1105	Belongs to the carbohydrate kinase PfkB family
H3299_RS09850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3299_RS09850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3299_RS09855	COG1609	Transcriptional regulator
H3299_RS09870	COG2807	transmembrane transport
H3299_RS09875	COG0400	carboxylic ester hydrolase activity
H3299_RS09890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H3299_RS09895	COG0594	ribonuclease P activity
H3299_RS09905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H3299_RS09920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H3299_RS09930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H3299_RS09945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H3299_RS09945	COG2857	Cytochrome c1
H3299_RS09950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H3299_RS09960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H3299_RS09965	COG0012	GTP binding
H3299_RS09970	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H3299_RS09985	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H3299_RS09990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H3299_RS09995	COG1268	BioY protein
H3299_RS10000	COG3338	carbonate dehydratase activity
H3299_RS10015	COG4106	trans-aconitate 2-methyltransferase activity
H3299_RS10020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H3299_RS10030	COG1278	Cold shock
H3299_RS10040	COG3655	Transcriptional regulator
H3299_RS10055	COG1120	ATPase activity
H3299_RS10080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H3299_RS10085	COG0358	DNA primase activity
H3299_RS10095	COG0668	transmembrane transport
H3299_RS10100	COG0459	protein refolding
H3299_RS10105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H3299_RS10120	COG1609	Transcriptional regulator
H3299_RS10140	COG0604	alcohol dehydrogenase
H3299_RS10160	COG0281	malic enzyme
H3299_RS10160	COG0280	phosphate acetyltransferase
H3299_RS10205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H3299_RS10215	COG0583	DNA-binding transcription factor activity
H3299_RS10230	COG0477	Major facilitator Superfamily
H3299_RS10235	COG0534	Mate efflux family protein
H3299_RS10240	COG0129	dihydroxy-acid dehydratase activity
H3299_RS10245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H3299_RS10250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H3299_RS10255	COG4208	sulfate ABC transporter
H3299_RS10260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H3299_RS10265	COG4150	thiosulfate binding
H3299_RS10275	COG4215	(ABC) transporter
H3299_RS10285	COG1126	abc transporter atp-binding protein
H3299_RS10290	COG0284	orotidine-5'-phosphate decarboxylase activity
H3299_RS10295	COG0427	acetyl-CoA hydrolase
H3299_RS10310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H3299_RS10320	COG0825	malonyl-CoA metabolic process
H3299_RS10335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H3299_RS10345	COG3676	manually curated
H3299_RS10355	COG1473	amidohydrolase
H3299_RS10375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H3299_RS10380	COG0509	glycine decarboxylation via glycine cleavage system
H3299_RS10385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H3299_RS10385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H3299_RS10410	COG4772	TonB-dependent receptor
H3299_RS10420	COG0531	amino acid
H3299_RS10435	COG0747	negative chemotaxis
H3299_RS10440	COG0747	negative chemotaxis
H3299_RS10450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3299_RS10455	COG1473	amidohydrolase
H3299_RS10465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3299_RS10470	COG0601	transmembrane transport
H3299_RS10485	COG0673	inositol 2-dehydrogenase activity
H3299_RS10505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H3299_RS10545	COG1335	isochorismatase
H3299_RS10550	COG4977	sequence-specific DNA binding
H3299_RS10570	COG0656	L-ascorbic acid biosynthetic process
H3299_RS10605	COG0137	argininosuccinate synthase activity
H3299_RS10610	COG4589	Belongs to the CDS family
H3299_RS10620	COG2453	phosphatase
H3299_RS10620	COG0671	phosphoesterase, PA-phosphatase related
H3299_RS10625	COG2267	carboxylic ester hydrolase activity
H3299_RS10630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H3299_RS10640	COG0477	Major facilitator Superfamily
H3299_RS10655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H3299_RS10660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3299_RS10680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3299_RS10720	COG0156	8-amino-7-oxononanoate synthase activity
H3299_RS10755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H3299_RS10760	COG0483	inositol monophosphate 1-phosphatase activity
H3299_RS10790	COG0662	Cupin 2, conserved barrel domain protein
H3299_RS10790	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H3299_RS10795	COG2233	PERMEase
H3299_RS10815	COG0494	nUDIX hydrolase
H3299_RS10820	COG0454	-acetyltransferase
H3299_RS10820	COG0456	acetyltransferase
H3299_RS10825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H3299_RS10840	COG2864	formate dehydrogenase
H3299_RS10845	COG0437	4 iron, 4 sulfur cluster binding
H3299_RS10870	COG1376	ErfK ybiS ycfS ynhG family protein
H3299_RS10870	COG1388	LysM domain
H3299_RS10880	COG4771	TonB-dependent receptor
H3299_RS10885	COG0656	L-ascorbic acid biosynthetic process
H3299_RS10915	COG2353	YceI-like domain
H3299_RS10920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H3299_RS10940	COG1902	pentaerythritol trinitrate reductase activity
H3299_RS10945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H3299_RS10945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H3299_RS10980	COG1335	isochorismatase
H3299_RS11025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H3299_RS11035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H3299_RS11040	COG0799	negative regulation of ribosome biogenesis
H3299_RS11050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H3299_RS11055	COG0167	dihydroorotate dehydrogenase activity
H3299_RS11075	COG0848	biopolymer transport protein
H3299_RS11085	COG3842	ATPase activity
H3299_RS11100	COG0395	ABC-type sugar transport system, permease component
H3299_RS11125	COG1126	abc transporter atp-binding protein
H3299_RS11155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3299_RS11165	COG2346	COG2346, Truncated hemoglobins
H3299_RS11175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H3299_RS11190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H3299_RS11195	COG0567	Dehydrogenase, E1 component
H3299_RS11200	COG0508	dehydrogenase complex catalyzes the overall conversion of
H3299_RS11235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H3299_RS11245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H3299_RS11245	COG0392	lysyltransferase activity
H3299_RS11290	COG2010	Cytochrome c
H3299_RS11295	COG4778	phosphonate C-P lyase system protein PhnL
H3299_RS11300	COG4107	phosphonate C-P lyase system protein PhnK
H3299_RS11305	COG3627	carbon phosphorus lyase activity
H3299_RS11325	COG2188	Transcriptional regulator
H3299_RS11330	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H3299_RS11335	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H3299_RS11340	COG3639	organic phosphonate transmembrane transporter activity
H3299_RS11345	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H3299_RS11350	COG3454	Phosphonate metabolism
H3299_RS11380	COG0745	RESPONSE REGULATOR receiver
H3299_RS11390	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H3299_RS11440	COG3501	Rhs element vgr protein
H3299_RS11450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H3299_RS11480	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H3299_RS11495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H3299_RS11515	COG0730	response to heat
H3299_RS11535	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H3299_RS11540	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H3299_RS11550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H3299_RS11560	COG0142	geranyltranstransferase activity
H3299_RS11590	COG0842	Transport permease protein
H3299_RS11595	COG1129	ABC transporter
H3299_RS11595	COG0842	Transport permease protein
H3299_RS11600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H3299_RS11605	COG2205	protein histidine kinase activity
H3299_RS11610	COG0745	RESPONSE REGULATOR receiver
H3299_RS11615	COG1846	Transcriptional regulator
H3299_RS11620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H3299_RS11625	COG0783	Belongs to the Dps family
H3299_RS11630	COG0217	transcriptional regulatory protein
H3299_RS11635	COG1268	BioY protein
H3299_RS11665	COG2205	protein histidine kinase activity
H3299_RS11670	COG0745	RESPONSE REGULATOR receiver
H3299_RS11685	COG2755	lipolytic protein G-D-S-L family
H3299_RS11685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H3299_RS11690	COG0601	transmembrane transport
H3299_RS11695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3299_RS11700	COG0444	Belongs to the ABC transporter superfamily
H3299_RS11705	COG4608	Belongs to the ABC transporter superfamily
H3299_RS11710	COG1739	Uncharacterized protein family UPF0029
H3299_RS11745	COG0287	Prephenate dehydrogenase
H3299_RS11755	COG0729	surface antigen
H3299_RS11765	COG0484	heat shock protein binding
H3299_RS11795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H3299_RS11820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3299_RS11825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H3299_RS11835	COG5328	Belongs to the UPF0262 family
H3299_RS11855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H3299_RS11860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H3299_RS11865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H3299_RS11885	COG1185	polyribonucleotide nucleotidyltransferase activity
H3299_RS11890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H3299_RS11900	COG0659	secondary active sulfate transmembrane transporter activity
H3299_RS11905	COG0589	response to stress
H3299_RS11910	COG0473	3-isopropylmalate dehydrogenase activity
H3299_RS11920	COG0492	ferredoxin-NADP+ reductase activity
H3299_RS11925	COG0583	DNA-binding transcription factor activity
H3299_RS11965	COG0793	Belongs to the peptidase S41A family
H3299_RS11975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H3299_RS11980	COG1946	Acyl-CoA thioesterase
H3299_RS12015	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H3299_RS12020	COG2835	tetraacyldisaccharide 4'-kinase activity
H3299_RS12025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H3299_RS12030	COG3135	benzoate transporter
H3299_RS12040	COG0612	Peptidase, M16
H3299_RS12045	COG0612	Peptidase, M16
H3299_RS12050	COG0742	ribosomal rna small subunit methyltransferase
H3299_RS12070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H3299_RS12095	COG1473	amidohydrolase
H3299_RS12100	COG0717	Belongs to the dCTP deaminase family
H3299_RS12140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3299_RS12145	COG0174	glutamine synthetase
H3299_RS12230	COG1024	Enoyl-CoA hydratase
H3299_RS12235	COG0500	methyltransferase
H3299_RS12245	COG1921	L-seryl-tRNASec selenium transferase activity
H3299_RS12260	COG1201	RNA secondary structure unwinding
H3299_RS12365	COG1783	phage Terminase large subunit
H3299_RS12390	COG0667	Aldo Keto reductase
H3299_RS12395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3299_RS12435	COG1120	ATPase activity
H3299_RS12480	COG1335	isochorismatase
H3299_RS12490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H3299_RS12505	COG3920	Histidine kinase
H3299_RS12505	COG2202	Pas domain
H3299_RS12555	COG1609	Transcriptional regulator
H3299_RS12560	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
H3299_RS12565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3299_RS12570	COG1172	Belongs to the binding-protein-dependent transport system permease family
H3299_RS12580	COG4213	ABC transporter substrate-binding protein
H3299_RS12630	COG0745	RESPONSE REGULATOR receiver
H3299_RS12635	COG0704	Plays a role in the regulation of phosphate uptake
H3299_RS12640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H3299_RS12650	COG0573	inorganic phosphate transmembrane transporter activity
H3299_RS12660	COG0189	ligase activity
H3299_RS12665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H3299_RS12670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3299_RS12705	COG0501	Belongs to the peptidase M48B family
H3299_RS12710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H3299_RS12710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H3299_RS12720	COG2309	aminopeptidase activity
H3299_RS12725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3299_RS12730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3299_RS12745	COG4172	Belongs to the ABC transporter superfamily
H3299_RS12750	COG4239	(ABC) transporter, permease
H3299_RS12755	COG4174	ABC transporter (Permease)
H3299_RS12760	COG4166	transmembrane transport
H3299_RS12765	COG3474	cytochrome
H3299_RS12785	COG2340	Cysteine-rich secretory protein family
H3299_RS12795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3299_RS12795	COG2169	Transcriptional regulator
H3299_RS12800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H3299_RS12805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H3299_RS12815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H3299_RS12820	COG0072	phenylalanine-tRNA ligase activity
H3299_RS12820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3299_RS12845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H3299_RS12850	COG4133	protoheme IX ABC transporter activity
H3299_RS12855	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H3299_RS12860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H3299_RS12870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3299_RS12885	COG0644	oxidoreductase
H3299_RS12955	COG3052	prosthetic group binding
H3299_RS12975	COG1802	Transcriptional regulator
H3299_RS12985	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H3299_RS12995	COG0714	Associated with various cellular activities
H3299_RS13000	COG3831	ATPase activity
H3299_RS13005	COG3831	ATPase activity
H3299_RS13010	COG3831	ATPase activity
H3299_RS13030	COG3831	ATPase activity
H3299_RS13065	COG3501	Rhs element vgr protein
H3299_RS13070	COG3501	Rhs element vgr protein
H3299_RS13135	COG0183	Belongs to the thiolase family
H3299_RS13140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H3299_RS13150	COG0477	Major facilitator Superfamily
H3299_RS13180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H3299_RS13190	COG0709	Synthesizes selenophosphate from selenide and ATP
H3299_RS13195	COG1692	metallophosphoesterase
H3299_RS13215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H3299_RS13220	COG0495	leucyl-tRNA aminoacylation
H3299_RS13235	COG0457	Tetratricopeptide repeat
H3299_RS13245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H3299_RS13260	COG0490	domain, Protein
H3299_RS13260	COG0471	metal ion transport
H3299_RS13305	COG0357	Ribosomal RNA small subunit methyltransferase G
H3299_RS13310	COG0445	tRNA wobble uridine modification
H3299_RS13315	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H3299_RS13320	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H3299_RS13325	COG0640	Transcriptional regulator
H3299_RS13335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3299_RS13335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3299_RS13350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H3299_RS13360	COG0523	cobalamin synthesis protein
H3299_RS13370	COG0747	negative chemotaxis
H3299_RS13375	COG0601	transmembrane transport
H3299_RS13380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3299_RS13390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H3299_RS13415	COG0312	modulator of DNA gyrase
H3299_RS13425	COG2217	Heavy metal translocating P-type atpase
H3299_RS13450	COG1741	Belongs to the pirin family
H3299_RS13470	COG3128	pkhd-type hydroxylase
H3299_RS13475	COG4774	siderophore transport
H3299_RS13485	COG2900	Belongs to the SlyX family
H3299_RS13515	COG0539	negative regulation of cytoplasmic translation
H3299_RS13525	COG2832	Protein of unknown function (DUF454)
H3299_RS13530	COG3237	CsbD-like
H3299_RS13545	COG1028	Short-chain dehydrogenase reductase Sdr
H3299_RS13550	COG0778	Nitroreductase
H3299_RS13565	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H3299_RS13575	COG1522	sequence-specific DNA binding
H3299_RS13585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H3299_RS13590	COG4558	Periplasmic binding protein
H3299_RS13610	COG1177	transmembrane transport
H3299_RS13615	COG1176	ABC-type spermidine putrescine transport system, permease component I
H3299_RS13620	COG3842	ATPase activity
H3299_RS13645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H3299_RS13650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3299_RS13655	COG0653	protein targeting
H3299_RS13665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H3299_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
H3299_RS13685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H3299_RS13690	COG0363	glucosamine-6-phosphate deaminase activity
H3299_RS13695	COG3459	Glycosyltransferase 36 associated
H3299_RS13700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H3299_RS13705	COG0237	dephospho-CoA kinase activity
H3299_RS13710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H3299_RS13715	COG0424	maF-like protein
H3299_RS13750	COG0010	Belongs to the arginase family
H3299_RS13755	COG2070	2-Nitropropane dioxygenase
H3299_RS13780	COG0714	Associated with various cellular activities
H3299_RS13785	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H3299_RS13790	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H3299_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
H3299_RS13810	COG1028	Short-chain dehydrogenase reductase Sdr
H3299_RS13835	COG0697	spore germination
H3299_RS13840	COG0019	diaminopimelate decarboxylase activity
H3299_RS13865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H3299_RS13870	COG0071	Belongs to the small heat shock protein (HSP20) family
H3299_RS13880	COG2862	Uncharacterized protein family, UPF0114
H3299_RS13905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H3299_RS13910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H3299_RS13915	COG0552	protein localization to endoplasmic reticulum
H3299_RS13960	COG4191	Histidine kinase
H3299_RS13965	COG4566	intracellular signal transduction
H3299_RS13970	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H3299_RS14040	COG0671	phosphoesterase, PA-phosphatase related
H3299_RS14045	COG1132	(ABC) transporter
H3299_RS14060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H3299_RS14070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H3299_RS14075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H3299_RS14080	COG0739	heme binding
H3299_RS14120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H3299_RS14130	COG0564	pseudouridine synthase activity
H3299_RS14140	COG3048	D-serine ammonia-lyase activity
H3299_RS14230	COG1840	ABC-type Fe3 transport system, periplasmic component
H3299_RS14235	COG3842	ATPase activity
H3299_RS14265	COG1309	transcriptional regulator
H3299_RS14275	COG1122	ATPase activity
H3299_RS14300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3299_RS14335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H3299_RS14340	COG2816	NAD+ diphosphatase activity
H3299_RS14355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H3299_RS14360	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H3299_RS14365	COG0183	Belongs to the thiolase family
H3299_RS14370	COG2188	Transcriptional regulator
H3299_RS14375	COG0579	oxidoreductase
H3299_RS14400	COG0583	DNA-binding transcription factor activity
H3299_RS14405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H3299_RS14410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H3299_RS14415	COG3485	protocatechuate 3,4-dioxygenase
H3299_RS14420	COG3485	protocatechuate 3,4-dioxygenase
H3299_RS14425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H3299_RS14435	COG0673	inositol 2-dehydrogenase activity
H3299_RS14440	COG1053	succinate dehydrogenase
H3299_RS14445	COG1053	succinate dehydrogenase
H3299_RS14480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H3299_RS14485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H3299_RS14495	COG1192	Involved in chromosome partitioning
H3299_RS14500	COG1475	DNA binding
H3299_RS14525	COG2076	Multidrug Resistance protein
H3299_RS14540	COG0745	RESPONSE REGULATOR receiver
H3299_RS14545	COG3850	Histidine kinase
H3299_RS14545	COG5002	protein histidine kinase activity
H3299_RS14565	COG1088	dTDP-glucose 4,6-dehydratase activity
H3299_RS14580	COG2720	vancomycin resistance protein
H3299_RS14665	COG3609	addiction module antidote protein, CC2985 family
H3299_RS14670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H3299_RS14675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3299_RS14680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H3299_RS14685	COG0814	amino acid
H3299_RS14690	COG1448	Aminotransferase
H3299_RS14705	COG1113	amino acid transport
H3299_RS14730	COG1696	Membrane protein involved in D-alanine export
H3299_RS14755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3299_RS14765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3299_RS14810	COG2188	Transcriptional regulator
H3299_RS14825	COG4120	Belongs to the binding-protein-dependent transport system permease family
H3299_RS14830	COG1122	ATPase activity
H3299_RS14835	COG2814	Major facilitator Superfamily
H3299_RS14850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H3299_RS14860	COG2986	histidine ammonia-lyase
H3299_RS14865	COG1228	amidohydrolase
H3299_RS14890	COG1268	BioY protein
H3299_RS14900	COG1116	anion transmembrane transporter activity
H3299_RS14905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H3299_RS14910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3299_RS14960	COG2373	Large extracellular alpha-helical protein
H3299_RS14965	COG4953	penicillin-binding protein 1C
H3299_RS15010	COG2315	Protein conserved in bacteria
H3299_RS15030	COG2814	Major facilitator Superfamily
H3299_RS15045	COG0371	Dehydrogenase
H3299_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
H3299_RS15075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H3299_RS15080	COG2313	pseudouridylate synthase activity
H3299_RS15085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3299_RS15135	COG1063	alcohol dehydrogenase
H3299_RS15140	COG1396	sequence-specific DNA binding
H3299_RS15140	COG3800	Transcriptional regulator
H3299_RS15145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H3299_RS15150	COG4770	biotin carboxylase activity
H3299_RS15155	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3299_RS15155	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H3299_RS15160	COG0346	lactoylglutathione lyase activity
H3299_RS15205	COG0477	Major facilitator Superfamily
H3299_RS15215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3299_RS15230	COG0583	DNA-binding transcription factor activity
H3299_RS15240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3299_RS15285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H3299_RS15295	COG0803	Belongs to the bacterial solute-binding protein 9 family
H3299_RS15300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3299_RS15315	COG1475	DNA binding
H3299_RS15320	COG1192	Involved in chromosome partitioning
H3299_RS15430	COG2161	toxin-antitoxin pair type II binding
H3299_RS15435	COG4115	mRNA cleavage
H3299_RS15460	COG3188	usher protein
H3299_RS15485	COG3609	addiction module antidote protein, CC2985 family
H3299_RS15515	COG4245	von Willebrand factor, type A