locus-tag	class	description
N5853_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N5853_RS00010	COG2890	protein-(glutamine-N5) methyltransferase activity
N5853_RS00015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N5853_RS00030	COG0488	(ABC) transporter
N5853_RS00035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N5853_RS00060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N5853_RS00060	COG2169	Transcriptional regulator
N5853_RS00065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N5853_RS00070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N5853_RS00080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N5853_RS00085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N5853_RS00085	COG0072	phenylalanine-tRNA ligase activity
N5853_RS00095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N5853_RS00100	COG4133	protoheme IX ABC transporter activity
N5853_RS00105	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N5853_RS00110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N5853_RS00120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N5853_RS00130	COG0644	oxidoreductase
N5853_RS00145	COG1129	ABC transporter
N5853_RS00150	COG1172	Belongs to the binding-protein-dependent transport system permease family
N5853_RS00155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5853_RS00160	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
N5853_RS00165	COG1609	Transcriptional regulator
N5853_RS00200	COG0483	inositol monophosphate 1-phosphatase activity
N5853_RS00215	COG2202	Pas domain
N5853_RS00215	COG3920	Histidine kinase
N5853_RS00220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N5853_RS00225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N5853_RS00230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N5853_RS00235	COG1335	isochorismatase
N5853_RS00240	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N5853_RS00270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N5853_RS00285	COG0010	Belongs to the arginase family
N5853_RS00290	COG2070	2-Nitropropane dioxygenase
N5853_RS00300	COG3048	D-serine ammonia-lyase activity
N5853_RS00310	COG0564	pseudouridine synthase activity
N5853_RS00315	COG2096	Adenosyltransferase
N5853_RS00365	COG2720	vancomycin resistance protein
N5853_RS00385	COG4172	Belongs to the ABC transporter superfamily
N5853_RS00390	COG4239	(ABC) transporter, permease
N5853_RS00395	COG4174	ABC transporter (Permease)
N5853_RS00400	COG4166	transmembrane transport
N5853_RS00405	COG3474	cytochrome
N5853_RS00410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N5853_RS00415	COG1605	Chorismate mutase
N5853_RS00415	COG0077	Prephenate dehydratase
N5853_RS00425	COG2340	Cysteine-rich secretory protein family
N5853_RS00430	COG0583	DNA-binding transcription factor activity
N5853_RS00435	COG1741	Belongs to the pirin family
N5853_RS00440	COG0523	cobalamin synthesis protein
N5853_RS00445	COG2217	Heavy metal translocating P-type atpase
N5853_RS00475	COG0642	Histidine kinase
N5853_RS00490	COG1309	transcriptional regulator
N5853_RS00500	COG3459	Glycosyltransferase 36 associated
N5853_RS00505	COG0363	glucosamine-6-phosphate deaminase activity
N5853_RS00510	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N5853_RS00520	COG0673	inositol 2-dehydrogenase activity
N5853_RS00525	COG1082	Xylose isomerase domain protein TIM barrel
N5853_RS00530	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS00565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N5853_RS00570	COG0488	(ABC) transporter
N5853_RS00590	COG1122	ATPase activity
N5853_RS00615	COG0653	protein targeting
N5853_RS00620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N5853_RS00625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N5853_RS00645	COG3842	ATPase activity
N5853_RS00650	COG1176	ABC-type spermidine putrescine transport system, permease component I
N5853_RS00655	COG1177	transmembrane transport
N5853_RS00675	COG4558	Periplasmic binding protein
N5853_RS00680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5853_RS00690	COG1522	sequence-specific DNA binding
N5853_RS00700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
N5853_RS00710	COG0778	Nitroreductase
N5853_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS00730	COG3237	CsbD-like
N5853_RS00735	COG2832	Protein of unknown function (DUF454)
N5853_RS00805	COG3829	transcription factor binding
N5853_RS00870	COG3501	Rhs element vgr protein
N5853_RS00905	COG0539	negative regulation of cytoplasmic translation
N5853_RS00940	COG2900	Belongs to the SlyX family
N5853_RS00955	COG0237	dephospho-CoA kinase activity
N5853_RS00960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N5853_RS00965	COG0424	maF-like protein
N5853_RS00980	COG1595	DNA-templated transcription, initiation
N5853_RS00985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N5853_RS00995	COG1981	membrane
N5853_RS01000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N5853_RS01000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N5853_RS01010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N5853_RS01015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N5853_RS01020	COG0445	tRNA wobble uridine modification
N5853_RS01025	COG0357	Ribosomal RNA small subunit methyltransferase G
N5853_RS01055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N5853_RS01060	COG1217	gtp-binding protein TYPA
N5853_RS01065	COG0709	Synthesizes selenophosphate from selenide and ATP
N5853_RS01070	COG1692	metallophosphoesterase
N5853_RS01095	COG0471	metal ion transport
N5853_RS01095	COG0490	domain, Protein
N5853_RS01115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N5853_RS01130	COG2423	ornithine cyclodeaminase activity
N5853_RS01145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N5853_RS01145	COG0519	Catalyzes the synthesis of GMP from XMP
N5853_RS01150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5853_RS01155	COG0174	glutamine synthetase
N5853_RS01160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N5853_RS01165	COG0495	leucyl-tRNA aminoacylation
N5853_RS01180	COG0457	Tetratricopeptide repeat
N5853_RS01190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N5853_RS01230	COG0477	Major facilitator Superfamily
N5853_RS01240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N5853_RS01245	COG0183	Belongs to the thiolase family
N5853_RS01250	COG3185	4-Hydroxyphenylpyruvate dioxygenase
N5853_RS01250	COG1082	Xylose isomerase domain protein TIM barrel
N5853_RS01315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N5853_RS01320	COG2887	Belongs to the helicase family. UvrD subfamily
N5853_RS01325	COG1074	ATP-dependent DNA helicase activity
N5853_RS01340	COG2862	Uncharacterized protein family, UPF0114
N5853_RS01355	COG1132	(ABC) transporter
N5853_RS01365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
N5853_RS01370	COG0288	reversible hydration of carbon dioxide
N5853_RS01375	COG0183	Belongs to the thiolase family
N5853_RS01395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N5853_RS01415	COG2816	NAD+ diphosphatase activity
N5853_RS01420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N5853_RS01450	COG2902	Dehydrogenase
N5853_RS01460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N5853_RS01470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N5853_RS01475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N5853_RS01480	COG0739	heme binding
N5853_RS01515	COG3676	manually curated
N5853_RS01535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N5853_RS01540	COG3552	Protein containing von Willebrand factor type A (VWA) domain
N5853_RS01545	COG2425	protein containing a von Willebrand factor type A (vWA) domain
N5853_RS01550	COG0714	Associated with various cellular activities
N5853_RS01570	COG0527	aspartate kinase activity
N5853_RS01575	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N5853_RS01590	COG0492	ferredoxin-NADP+ reductase activity
N5853_RS01595	COG0583	DNA-binding transcription factor activity
N5853_RS01620	COG0583	DNA-binding transcription factor activity
N5853_RS01625	COG2267	carboxylic ester hydrolase activity
N5853_RS01630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N5853_RS01635	COG3485	protocatechuate 3,4-dioxygenase
N5853_RS01640	COG3485	protocatechuate 3,4-dioxygenase
N5853_RS01645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N5853_RS01655	COG0673	inositol 2-dehydrogenase activity
N5853_RS01660	COG1053	succinate dehydrogenase
N5853_RS01665	COG1053	succinate dehydrogenase
N5853_RS01695	COG2309	aminopeptidase activity
N5853_RS01705	COG3842	ATPase activity
N5853_RS01740	COG4993	Dehydrogenase
N5853_RS01755	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N5853_RS01785	COG0720	synthase
N5853_RS01790	COG0602	queuosine metabolic process
N5853_RS01805	COG0174	glutamine synthetase
N5853_RS01810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5853_RS01825	COG0697	spore germination
N5853_RS01830	COG0019	diaminopimelate decarboxylase activity
N5853_RS01850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N5853_RS01855	COG0071	Belongs to the small heat shock protein (HSP20) family
N5853_RS01875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5853_RS01880	COG0667	Aldo Keto reductase
N5853_RS01905	COG1783	phage Terminase large subunit
N5853_RS02010	COG1201	RNA secondary structure unwinding
N5853_RS02035	COG0500	methyltransferase
N5853_RS02040	COG1024	Enoyl-CoA hydratase
N5853_RS02090	COG4774	siderophore transport
N5853_RS02095	COG3128	pkhd-type hydroxylase
N5853_RS02125	COG0483	inositol monophosphate 1-phosphatase activity
N5853_RS02130	COG0312	modulator of DNA gyrase
N5853_RS02140	COG0443	Heat shock 70 kDa protein
N5853_RS02145	COG0484	heat shock protein binding
N5853_RS02180	COG0604	alcohol dehydrogenase
N5853_RS02200	COG3842	ATPase activity
N5853_RS02205	COG1178	ABC-type Fe3 transport system permease component
N5853_RS02240	COG0640	Transcriptional regulator
N5853_RS02250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N5853_RS02255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N5853_RS02260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N5853_RS02270	COG0697	spore germination
N5853_RS02275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N5853_RS02295	COG0683	leucine binding
N5853_RS02320	COG3750	Belongs to the UPF0335 family
N5853_RS02335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N5853_RS02340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N5853_RS02345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N5853_RS02375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N5853_RS02385	COG1132	(ABC) transporter
N5853_RS02390	COG0285	dihydrofolate synthase activity
N5853_RS02400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N5853_RS02410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5853_RS02415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N5853_RS02420	COG0189	ligase activity
N5853_RS02430	COG0573	inorganic phosphate transmembrane transporter activity
N5853_RS02440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N5853_RS02445	COG0704	Plays a role in the regulation of phosphate uptake
N5853_RS02450	COG0745	RESPONSE REGULATOR receiver
N5853_RS02480	COG4191	Histidine kinase
N5853_RS02485	COG4566	intracellular signal transduction
N5853_RS02545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N5853_RS02560	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N5853_RS02560	COG0392	lysyltransferase activity
N5853_RS02580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N5853_RS02610	COG3588	fructose-bisphosphate aldolase
N5853_RS02640	COG1250	3-hydroxyacyl-CoA dehydrogenase
N5853_RS02650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N5853_RS02660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N5853_RS02670	COG0137	argininosuccinate synthase activity
N5853_RS02710	COG0672	)-iron permease
N5853_RS02720	COG0469	pyruvate kinase activity
N5853_RS02745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N5853_RS02755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N5853_RS02760	COG0799	negative regulation of ribosome biogenesis
N5853_RS02770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N5853_RS02780	COG0167	dihydroorotate dehydrogenase activity
N5853_RS02795	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N5853_RS02800	COG0848	biopolymer transport protein
N5853_RS02820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N5853_RS02840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N5853_RS02855	COG0784	Response regulator, receiver
N5853_RS02880	COG1129	ABC transporter
N5853_RS02885	COG1172	Belongs to the binding-protein-dependent transport system permease family
N5853_RS02920	COG1335	isochorismatase
N5853_RS02940	COG1674	ftsk spoiiie
N5853_RS02955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N5853_RS02955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N5853_RS02960	COG1902	pentaerythritol trinitrate reductase activity
N5853_RS02980	COG2353	YceI-like domain
N5853_RS03005	COG1388	LysM domain
N5853_RS03005	COG1376	ErfK ybiS ycfS ynhG family protein
N5853_RS03025	COG0437	4 iron, 4 sulfur cluster binding
N5853_RS03030	COG2864	formate dehydrogenase
N5853_RS03045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N5853_RS03050	COG0454	-acetyltransferase
N5853_RS03050	COG0456	acetyltransferase
N5853_RS03055	COG0494	nUDIX hydrolase
N5853_RS03075	COG2233	PERMEase
N5853_RS03080	COG0662	Cupin 2, conserved barrel domain protein
N5853_RS03080	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
N5853_RS03110	COG0483	inositol monophosphate 1-phosphatase activity
N5853_RS03115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N5853_RS03145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N5853_RS03150	COG0037	tRNA processing
N5853_RS03160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N5853_RS03185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N5853_RS03205	COG0280	phosphate acetyltransferase
N5853_RS03205	COG0281	malic enzyme
N5853_RS03240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N5853_RS03245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N5853_RS03275	COG1214	PFAM Peptidase M22, glycoprotease
N5853_RS03290	COG0471	metal ion transport
N5853_RS03290	COG3273	potassium ion transport
N5853_RS03300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N5853_RS03310	COG4149	molybdate abc transporter
N5853_RS03325	COG3047	cAMP biosynthetic process
N5853_RS03330	COG0459	protein refolding
N5853_RS03335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N5853_RS03365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N5853_RS03370	COG0509	glycine decarboxylation via glycine cleavage system
N5853_RS03375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N5853_RS03375	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N5853_RS03380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N5853_RS03390	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N5853_RS03395	COG0642	Histidine kinase
N5853_RS03400	COG0745	RESPONSE REGULATOR receiver
N5853_RS03430	COG0640	Transcriptional regulator
N5853_RS03445	COG3158	transport of potassium into the cell
N5853_RS03450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N5853_RS03455	COG1845	cytochrome c oxidase, subunit III
N5853_RS03460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N5853_RS03465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N5853_RS03470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N5853_RS03475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N5853_RS03485	COG1045	serine acetyltransferase
N5853_RS03490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N5853_RS03510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5853_RS03510	COG2813	Specifically methylates the guanine in position
N5853_RS03515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5853_RS03525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N5853_RS03545	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N5853_RS03580	COG1309	transcriptional regulator
N5853_RS03595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N5853_RS03600	COG0193	aminoacyl-tRNA hydrolase activity
N5853_RS03605	COG1620	l-lactate permease
N5853_RS03610	COG2186	Transcriptional regulator
N5853_RS03615	COG1304	FMN binding
N5853_RS03635	COG1218	3'(2'),5'-bisphosphate nucleotidase
N5853_RS03640	COG2226	methyltransferase
N5853_RS03645	COG1040	competence protein
N5853_RS03650	COG0792	nuclease activity
N5853_RS03655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N5853_RS03660	COG0436	Aminotransferase
N5853_RS03675	COG1120	ATPase activity
N5853_RS03680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5853_RS03715	COG2111	Na H antiporter
N5853_RS03715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N5853_RS03720	COG1006	Multisubunit Na H antiporter MnhC subunit
N5853_RS03725	COG0651	ATP synthesis coupled electron transport
N5853_RS03730	COG1863	multisubunit Na H antiporter MnhE subunit
N5853_RS03735	COG2212	antiporter activity
N5853_RS03740	COG1320	monovalent cation:proton antiporter activity
N5853_RS03745	COG1376	ErfK ybiS ycfS ynhG family protein
N5853_RS03755	COG0471	metal ion transport
N5853_RS03760	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N5853_RS03765	COG0583	DNA-binding transcription factor activity
N5853_RS03785	COG1970	mechanosensitive ion channel activity
N5853_RS03795	COG0754	glutathionylspermidine amidase activity
N5853_RS03800	COG5463	Belongs to the UPF0441 family
N5853_RS03805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N5853_RS03810	COG1702	phosphate starvation-inducible protein PhoH
N5853_RS03820	COG4535	Mg2 and Co2 transporter CorC
N5853_RS03825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N5853_RS03830	COG1396	sequence-specific DNA binding
N5853_RS03835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N5853_RS03840	COG0802	atpase or kinase
N5853_RS03845	COG2205	protein histidine kinase activity
N5853_RS03870	COG0110	maltose O-acetyltransferase activity
N5853_RS03885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N5853_RS03900	COG0670	Belongs to the BI1 family
N5853_RS03905	COG4181	ATPase activity
N5853_RS03940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N5853_RS03950	COG0477	Major facilitator Superfamily
N5853_RS03955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N5853_RS03975	COG0181	hydroxymethylbilane synthase activity
N5853_RS03980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N5853_RS04000	COG0829	nickel cation binding
N5853_RS04005	COG0831	urea catabolic process
N5853_RS04020	COG0804	urea catabolic process
N5853_RS04025	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
N5853_RS04030	COG0830	nickel cation binding
N5853_RS04035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N5853_RS04045	COG0784	Response regulator, receiver
N5853_RS04045	COG2198	Histidine kinase
N5853_RS04045	COG5002	protein histidine kinase activity
N5853_RS04080	COG2885	chlorophyll binding
N5853_RS04120	COG2840	Smr protein MutS2
N5853_RS04130	COG0159	tryptophan synthase activity
N5853_RS04150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5853_RS04170	COG0151	Belongs to the GarS family
N5853_RS04185	COG2884	Cell division ATP-binding protein ftsE
N5853_RS04200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N5853_RS04205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N5853_RS04220	COG0427	acetyl-CoA hydrolase
N5853_RS04225	COG0284	orotidine-5'-phosphate decarboxylase activity
N5853_RS04230	COG1126	abc transporter atp-binding protein
N5853_RS04240	COG4215	(ABC) transporter
N5853_RS04245	COG0384	phenazine biosynthesis protein PhzF
N5853_RS04250	COG4150	thiosulfate binding
N5853_RS04255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N5853_RS04260	COG4208	sulfate ABC transporter
N5853_RS04265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N5853_RS04270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N5853_RS04280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N5853_RS04285	COG0523	cobalamin synthesis protein
N5853_RS04300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N5853_RS04310	COG0673	inositol 2-dehydrogenase activity
N5853_RS04340	COG0583	DNA-binding transcription factor activity
N5853_RS04355	COG0477	Major facilitator Superfamily
N5853_RS04360	COG0534	Mate efflux family protein
N5853_RS04365	COG0129	dihydroxy-acid dehydratase activity
N5853_RS04370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N5853_RS04375	COG4604	ABC transporter, ATP-binding protein
N5853_RS04380	COG4605	iron ion homeostasis
N5853_RS04385	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5853_RS04390	COG4607	ABC-type enterochelin transport system periplasmic component
N5853_RS04395	COG2819	hydrolase of the alpha beta superfamily
N5853_RS04400	COG4771	TonB-dependent receptor
N5853_RS04405	COG2084	Dehydrogenase
N5853_RS04410	COG2205	protein histidine kinase activity
N5853_RS04415	COG2814	Major facilitator Superfamily
N5853_RS04430	COG0275	rRNA processing
N5853_RS04455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N5853_RS04475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N5853_RS04480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N5853_RS04495	COG0277	FAD linked oxidase domain protein
N5853_RS04500	COG0405	Gamma-glutamyltransferase
N5853_RS04505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N5853_RS04515	COG0210	DNA helicase
N5853_RS04520	COG0330	HflC and HflK could
N5853_RS04525	COG0330	HflC and HflK could
N5853_RS04530	COG0482	sulfurtransferase activity
N5853_RS04540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N5853_RS04545	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
N5853_RS04545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N5853_RS04555	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N5853_RS04570	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N5853_RS04590	COG3654	unkown
N5853_RS04595	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N5853_RS04600	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N5853_RS04635	COG3738	Protein conserved in bacteria
N5853_RS04640	COG0735	belongs to the Fur family
N5853_RS04665	COG0523	cobalamin synthesis protein
N5853_RS04675	COG1902	pentaerythritol trinitrate reductase activity
N5853_RS04680	COG2183	response to ionizing radiation
N5853_RS04710	COG0559	Belongs to the binding-protein-dependent transport system permease family
N5853_RS04730	COG1132	(ABC) transporter
N5853_RS04740	COG0546	phosphoglycolate phosphatase activity
N5853_RS04760	COG2095	MarC family integral membrane protein
N5853_RS04770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N5853_RS04775	COG4774	siderophore transport
N5853_RS04780	COG2207	Transcriptional regulator
N5853_RS04785	COG1120	ATPase activity
N5853_RS04790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N5853_RS04795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N5853_RS04810	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N5853_RS04815	COG0343	queuine tRNA-ribosyltransferase activity
N5853_RS04830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5853_RS04855	COG2813	Specifically methylates the guanine in position
N5853_RS04895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N5853_RS04915	COG0142	geranyltranstransferase activity
N5853_RS04930	COG0751	glycine-tRNA ligase activity
N5853_RS04935	COG0823	Involved in the tonB-independent uptake of proteins
N5853_RS04935	COG1506	peptidase
N5853_RS04940	COG2847	Copper chaperone PCu(A)C
N5853_RS04950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N5853_RS04965	COG0571	ribonuclease III activity
N5853_RS04970	COG0681	Belongs to the peptidase S26 family
N5853_RS04985	COG0521	Mo-molybdopterin cofactor biosynthetic process
N5853_RS04995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N5853_RS05000	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
N5853_RS05005	COG0535	radical SAM domain protein
N5853_RS05010	COG0535	radical SAM domain protein
N5853_RS05015	COG0163	prenyltransferase activity
N5853_RS05020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N5853_RS05025	COG3154	lipid carrier protein
N5853_RS05030	COG0826	peptidase U32
N5853_RS05045	COG4993	Dehydrogenase
N5853_RS05065	COG3152	Membrane
N5853_RS05075	COG3152	Membrane
N5853_RS05090	COG0714	Associated with various cellular activities
N5853_RS05115	COG0494	nUDIX hydrolase
N5853_RS05120	COG0740	serine-type endopeptidase activity
N5853_RS05150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N5853_RS05165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N5853_RS05170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N5853_RS05185	COG3023	N-Acetylmuramoyl-L-alanine amidase
N5853_RS05190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N5853_RS05220	COG0625	glutathione transferase activity
N5853_RS05230	COG3852	Histidine kinase
N5853_RS05235	COG2204	response regulator
N5853_RS05240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N5853_RS05250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N5853_RS05265	COG0081	regulation of translation
N5853_RS05275	COG0222	ribosome binding
N5853_RS05285	COG0085	RNA polymerase activity
N5853_RS05290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N5853_RS05305	COG2205	protein histidine kinase activity
N5853_RS05305	COG2202	Pas domain
N5853_RS05315	COG0519	Catalyzes the synthesis of GMP from XMP
N5853_RS05315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N5853_RS05345	COG0210	DNA helicase
N5853_RS05350	COG4625	pathogenesis
N5853_RS05355	COG0433	COG0433 Predicted ATPase
N5853_RS05370	COG1653	transport
N5853_RS05375	COG0395	ABC-type sugar transport system, permease component
N5853_RS05380	COG1175	transmembrane transport
N5853_RS05390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N5853_RS05395	COG1966	Carbon starvation protein
N5853_RS05400	COG2879	small protein
N5853_RS05405	COG0523	cobalamin synthesis protein
N5853_RS05415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N5853_RS05420	COG1780	Probably involved in ribonucleotide reductase function
N5853_RS05425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N5853_RS05435	COG1758	RNA polymerase activity
N5853_RS05450	COG2223	nitrite transmembrane transporter activity
N5853_RS05460	COG0438	transferase activity, transferring glycosyl groups
N5853_RS05460	COG1216	Glycosyl transferase, family 2
N5853_RS05465	COG0741	lytic transglycosylase activity
N5853_RS05480	COG0251	oxidation-reduction process
N5853_RS05495	COG0431	NADPH-dependent FMN reductase
N5853_RS05520	COG0556	nucleotide-excision repair
N5853_RS05530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N5853_RS05535	COG0765	amino acid transport
N5853_RS05540	COG1126	abc transporter atp-binding protein
N5853_RS05545	COG1802	Transcriptional regulator
N5853_RS05560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N5853_RS05570	COG1058	Belongs to the CinA family
N5853_RS05570	COG1546	Belongs to the CinA family
N5853_RS05600	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5853_RS05605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5853_RS05620	COG0649	NAD binding
N5853_RS05625	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
N5853_RS05630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N5853_RS05640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N5853_RS05645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5853_RS05655	COG0713	ATP synthesis coupled electron transport
N5853_RS05670	COG1007	ATP synthesis coupled electron transport
N5853_RS05690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N5853_RS05695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N5853_RS05700	COG1832	CoA-binding protein
N5853_RS05710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N5853_RS05720	COG1132	(ABC) transporter
N5853_RS05755	COG1278	Cold shock
N5853_RS05770	COG0667	Aldo Keto reductase
N5853_RS05775	COG0789	Transcriptional regulator
N5853_RS05790	COG1194	a g-specific adenine glycosylase
N5853_RS05795	COG0187	DNA topoisomerase II activity
N5853_RS05800	COG0321	lipoyl(octanoyl) transferase activity
N5853_RS05810	COG0194	GDP metabolic process
N5853_RS05815	COG1492	cobalamin metabolic process
N5853_RS05820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N5853_RS05835	COG1278	Cold shock
N5853_RS05845	COG1678	Uncharacterized ACR, COG1678
N5853_RS05850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N5853_RS05860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N5853_RS05875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N5853_RS05900	COG0745	RESPONSE REGULATOR receiver
N5853_RS05920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5853_RS05925	COG1183	phosphatidylcholine synthase activity
N5853_RS05935	COG1686	Belongs to the peptidase S11 family
N5853_RS05950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N5853_RS05955	COG0084	hydrolase, TatD family'
N5853_RS05960	COG0321	lipoyl(octanoyl) transferase activity
N5853_RS05960	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N5853_RS05965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N5853_RS06005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N5853_RS06010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N5853_RS06015	COG0544	peptidyl-prolyl cis-trans isomerase activity
N5853_RS06035	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N5853_RS06040	COG0248	Ppx GppA phosphatase
N5853_RS06045	COG0312	modulator of DNA gyrase
N5853_RS06065	COG0513	Belongs to the DEAD box helicase family
N5853_RS06085	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N5853_RS06095	COG1253	flavin adenine dinucleotide binding
N5853_RS06120	COG0305	Participates in initiation and elongation during chromosome replication
N5853_RS06155	COG3477	response to acidic pH
N5853_RS06170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N5853_RS06185	COG3209	COG3209 Rhs family protein
N5853_RS06205	COG3501	Rhs element vgr protein
N5853_RS06250	COG3956	TIGRFAM MazG family protein
N5853_RS06330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N5853_RS06345	COG0175	sulfate reduction
N5853_RS06355	COG2895	sulfate adenylyltransferase (ATP) activity
N5853_RS06365	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N5853_RS06385	COG2189	Belongs to the N(4) N(6)-methyltransferase family
N5853_RS06390	COG4717	serine-type aminopeptidase activity
N5853_RS06395	COG0420	3'-5' exonuclease activity
N5853_RS06425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N5853_RS06430	COG2814	Major facilitator Superfamily
N5853_RS06455	COG0277	FAD linked oxidase domain protein
N5853_RS06460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N5853_RS06465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N5853_RS06470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N5853_RS06475	COG0356	it plays a direct role in the translocation of protons across the membrane
N5853_RS06490	COG1160	GTP binding
N5853_RS06500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N5853_RS06510	COG0243	molybdopterin cofactor binding
N5853_RS06520	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N5853_RS06525	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N5853_RS06530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N5853_RS06535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N5853_RS06540	COG0805	protein transport
N5853_RS06550	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N5853_RS06555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N5853_RS06560	COG4942	peptidase
N5853_RS06560	COG1388	LysM domain
N5853_RS06570	COG0488	(ABC) transporter
N5853_RS06575	COG0105	UTP biosynthetic process
N5853_RS06585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N5853_RS06600	COG0314	molybdopterin synthase activity
N5853_RS06605	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N5853_RS06610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N5853_RS06660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5853_RS06695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N5853_RS06700	COG1138	Cytochrome C-type biogenesis protein
N5853_RS06705	COG3088	subunit of a heme lyase
N5853_RS06710	COG3577	Aspartyl protease
N5853_RS06715	COG0196	riboflavin kinase activity
N5853_RS06725	COG0612	Peptidase, M16
N5853_RS06735	COG0628	permease
N5853_RS06745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N5853_RS06760	COG0442	prolyl-tRNA aminoacylation
N5853_RS06775	COG2197	response regulator
N5853_RS06780	COG4585	Histidine kinase
N5853_RS06785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N5853_RS06795	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N5853_RS06805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N5853_RS06810	COG0215	cysteine-tRNA ligase activity
N5853_RS06820	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS06840	COG1764	response to oxidative stress
N5853_RS06845	COG0308	aminopeptidase N
N5853_RS06855	COG1573	uracil-dna glycosylase
N5853_RS06860	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
N5853_RS06875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N5853_RS06915	COG0596	Alpha beta hydrolase
N5853_RS06925	COG0537	adenosine 5'-monophosphoramidase activity
N5853_RS06945	COG0740	serine-type endopeptidase activity
N5853_RS06955	COG0569	domain protein
N5853_RS06960	COG2204	response regulator
N5853_RS06965	COG5000	phosphorelay sensor kinase activity
N5853_RS06970	COG1959	2 iron, 2 sulfur cluster binding
N5853_RS06975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N5853_RS06990	COG2003	Belongs to the UPF0758 family
N5853_RS06995	COG0024	Methionine aminopeptidase
N5853_RS07000	COG1489	DNA binding
N5853_RS07005	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N5853_RS07010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N5853_RS07025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N5853_RS07040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N5853_RS07050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N5853_RS07055	COG3835	regulator
N5853_RS07060	COG1126	abc transporter atp-binding protein
N5853_RS07065	COG0765	amino acid transport
N5853_RS07070	COG4597	amino acid ABC transporter
N5853_RS07075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N5853_RS07080	COG0626	cystathionine gamma-synthase activity
N5853_RS07100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N5853_RS07110	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N5853_RS07145	COG0477	Major facilitator Superfamily
N5853_RS07150	COG1957	nucleoside hydrolase
N5853_RS07160	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N5853_RS07170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N5853_RS07185	COG2181	nitrate reductase activity
N5853_RS07190	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
N5853_RS07195	COG1140	nitrate reductase beta subunit
N5853_RS07200	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
N5853_RS07205	COG2223	nitrite transmembrane transporter activity
N5853_RS07225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N5853_RS07255	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N5853_RS07260	COG3180	Ammonia monooxygenase
N5853_RS07270	COG0316	Belongs to the HesB IscA family
N5853_RS07290	COG0750	zinc metalloprotease
N5853_RS07295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N5853_RS07300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5853_RS07315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5853_RS07325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N5853_RS07335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N5853_RS07335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N5853_RS07345	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N5853_RS07360	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N5853_RS07365	COG1054	Belongs to the UPF0176 family
N5853_RS07370	COG1612	heme a metabolic process
N5853_RS07375	COG0113	porphobilinogen synthase activity
N5853_RS07390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N5853_RS07395	COG0037	tRNA processing
N5853_RS07400	COG1113	amino acid transport
N5853_RS07415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N5853_RS07425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N5853_RS07430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N5853_RS07440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N5853_RS07445	COG4166	transmembrane transport
N5853_RS07455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N5853_RS07465	COG0546	phosphoglycolate phosphatase activity
N5853_RS07470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N5853_RS07475	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N5853_RS07480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N5853_RS07485	COG0052	Belongs to the universal ribosomal protein uS2 family
N5853_RS07490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N5853_RS07545	COG3265	gluconokinase activity
N5853_RS07550	COG0180	Tryptophanyl-tRNA synthetase
N5853_RS07555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N5853_RS07555	COG3218	ABC-type transport auxiliary lipoprotein component
N5853_RS07565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N5853_RS07565	COG3218	ABC-type transport auxiliary lipoprotein component
N5853_RS07570	COG1127	ABC transporter
N5853_RS07585	COG0280	phosphate acetyltransferase
N5853_RS07585	COG0281	malic enzyme
N5853_RS07590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N5853_RS07595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N5853_RS07600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N5853_RS07615	COG2875	Belongs to the precorrin methyltransferase family
N5853_RS07620	COG2885	chlorophyll binding
N5853_RS07625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N5853_RS07630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N5853_RS07665	COG0315	cyclic pyranopterin monophosphate synthase activity
N5853_RS07670	COG0303	'Molybdopterin
N5853_RS07695	COG3106	COG3106 Predicted ATPase
N5853_RS07710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N5853_RS07715	COG1686	Belongs to the peptidase S11 family
N5853_RS07720	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N5853_RS07730	COG0277	FAD linked oxidase domain protein
N5853_RS07740	COG2897	thiosulfate sulfurtransferase activity
N5853_RS07775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5853_RS07785	COG0372	Belongs to the citrate synthase family
N5853_RS07850	COG1172	Belongs to the binding-protein-dependent transport system permease family
N5853_RS07855	COG1172	Belongs to the binding-protein-dependent transport system permease family
N5853_RS07860	COG1129	ABC transporter
N5853_RS07865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N5853_RS07885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N5853_RS07890	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N5853_RS07905	COG0233	cytoplasmic translational termination
N5853_RS07925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5853_RS07930	COG1573	uracil-dna glycosylase
N5853_RS07940	COG0625	glutathione transferase activity
N5853_RS07945	COG1763	Mo-molybdopterin cofactor biosynthetic process
N5853_RS07950	COG0746	molybdenum cofactor guanylyltransferase activity
N5853_RS07960	COG1862	Preprotein translocase
N5853_RS07985	COG0745	RESPONSE REGULATOR receiver
N5853_RS07990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5853_RS07995	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
N5853_RS08000	COG2814	Major facilitator Superfamily
N5853_RS08005	COG1797	cobyrinic acid a,c-diamide synthase activity
N5853_RS08020	COG0633	Ferredoxin
N5853_RS08040	COG1522	sequence-specific DNA binding
N5853_RS08060	COG3188	usher protein
N5853_RS08085	COG0728	peptidoglycan biosynthetic process
N5853_RS08110	COG0436	Aminotransferase
N5853_RS08115	COG0501	Belongs to the peptidase M48B family
N5853_RS08125	COG0511	ligase activity, forming carbon-carbon bonds
N5853_RS08135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N5853_RS08145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N5853_RS08150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N5853_RS08155	COG0149	triose-phosphate isomerase activity
N5853_RS08175	COG2226	methyltransferase
N5853_RS08195	COG2274	protein secretion by the type I secretion system
N5853_RS08200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5853_RS08235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N5853_RS08240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N5853_RS08255	COG2945	thiolester hydrolase activity
N5853_RS08260	COG1104	cysteine desulfurase activity
N5853_RS08265	COG0719	Fe-S assembly protein
N5853_RS08270	COG0396	ATPase activity
N5853_RS08275	COG0719	Fe-S assembly protein
N5853_RS08280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N5853_RS08285	COG2151	metal-sulfur cluster biosynthetic enzyme
N5853_RS08300	COG0583	DNA-binding transcription factor activity
N5853_RS08305	COG2855	membrane
N5853_RS08315	COG0200	Binds to the 23S rRNA
N5853_RS08325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N5853_RS08335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N5853_RS08345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N5853_RS08355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N5853_RS08360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N5853_RS08375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N5853_RS08390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N5853_RS08405	COG0088	Forms part of the polypeptide exit tunnel
N5853_RS08410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N5853_RS08420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N5853_RS08435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N5853_RS08450	COG0765	amino acid transport
N5853_RS08455	COG0765	amino acid transport
N5853_RS08460	COG1126	abc transporter atp-binding protein
N5853_RS08465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5853_RS08480	COG1012	belongs to the aldehyde dehydrogenase family
N5853_RS08485	COG3108	Peptidase M15
N5853_RS08500	COG1196	nuclear chromosome segregation
N5853_RS08510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N5853_RS08530	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N5853_RS08535	COG0330	HflC and HflK could
N5853_RS08540	COG1585	Membrane protein implicated in regulation of membrane protease activity
N5853_RS08555	COG2204	response regulator
N5853_RS08575	COG0070	glutamate synthase
N5853_RS08575	COG0067	glutamate synthase
N5853_RS08575	COG0069	glutamate synthase activity
N5853_RS08580	COG0025	NhaP-type Na H and K H
N5853_RS08590	COG2166	iron-sulfur cluster assembly
N5853_RS08605	COG2205	protein histidine kinase activity
N5853_RS08625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N5853_RS08640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N5853_RS08655	COG0024	Methionine aminopeptidase
N5853_RS08675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N5853_RS08675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N5853_RS08680	COG1722	exodeoxyribonuclease VII activity
N5853_RS08690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N5853_RS08695	COG0785	Cytochrome C biogenesis protein
N5853_RS08710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N5853_RS08720	COG1530	ribonuclease E activity
N5853_RS08740	COG0174	glutamine synthetase
N5853_RS08745	COG0347	Belongs to the P(II) protein family
N5853_RS08750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N5853_RS08750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N5853_RS08755	COG0360	Binds together with S18 to 16S ribosomal RNA
N5853_RS08760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N5853_RS08775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N5853_RS08780	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS08785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N5853_RS08810	COG4178	(ABC) transporter
N5853_RS08830	COG3720	iron ion transport
N5853_RS08840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5853_RS08845	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N5853_RS08860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N5853_RS08865	COG1132	(ABC) transporter
N5853_RS08870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N5853_RS08875	COG4957	zinc ion binding
N5853_RS08890	COG0617	tRNA 3'-terminal CCA addition
N5853_RS08895	COG0494	nUDIX hydrolase
N5853_RS08900	COG0714	Associated with various cellular activities
N5853_RS08925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N5853_RS08930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N5853_RS08935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N5853_RS08940	COG0557	exoribonuclease II activity
N5853_RS08945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N5853_RS08945	COG1754	DNA topoisomerase type I activity
N5853_RS08955	COG0758	DNA mediated transformation
N5853_RS08960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N5853_RS08990	COG0436	Aminotransferase
N5853_RS09000	COG1494	fructose-1,6-bisphosphatase
N5853_RS09020	COG1278	Cold shock
N5853_RS09030	COG0512	Glutamine amidotransferase of anthranilate synthase
N5853_RS09030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N5853_RS09035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N5853_RS09045	COG0071	Belongs to the small heat shock protein (HSP20) family
N5853_RS09055	COG0483	inositol monophosphate 1-phosphatase activity
N5853_RS09090	COG1346	cytolysis
N5853_RS09095	COG1380	Effector of murein hydrolase LrgA
N5853_RS09100	COG0583	DNA-binding transcription factor activity
N5853_RS09120	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N5853_RS09125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N5853_RS09130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N5853_RS09140	COG0784	Response regulator, receiver
N5853_RS09145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N5853_RS09155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N5853_RS09170	COG0202	RNA polymerase activity
N5853_RS09180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N5853_RS09185	COG0563	adenylate kinase activity
N5853_RS09195	COG0513	Belongs to the DEAD box helicase family
N5853_RS09205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N5853_RS09455	COG3179	chitinase
N5853_RS09535	COG3264	Mechanosensitive ion channel
N5853_RS09535	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N5853_RS09545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N5853_RS09555	COG4651	solute:proton antiporter activity
N5853_RS09555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N5853_RS09580	COG0776	regulation of translation
N5853_RS09585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N5853_RS09615	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N5853_RS09620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N5853_RS09635	COG2239	Acts as a magnesium transporter
N5853_RS09650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N5853_RS09665	COG1183	phosphatidylcholine synthase activity
N5853_RS09670	COG0688	phosphatidylethanolamine metabolic process
N5853_RS09675	COG5265	(ABC) transporter
N5853_RS09680	COG2823	Periplasmic or secreted lipoprotein
N5853_RS09680	COG1652	LysM domain
N5853_RS09685	COG1611	Belongs to the LOG family
N5853_RS09695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N5853_RS09710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N5853_RS09720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N5853_RS09730	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
N5853_RS09755	COG0456	acetyltransferase
N5853_RS09790	COG0504	CTP synthase activity
N5853_RS09800	COG0148	phosphopyruvate hydratase activity
N5853_RS09805	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N5853_RS09815	COG1121	(ABC) transporter
N5853_RS09820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N5853_RS09825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N5853_RS09830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N5853_RS09855	COG3962	Belongs to the TPP enzyme family
N5853_RS09860	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS09885	COG1129	ABC transporter
N5853_RS09890	COG1172	Belongs to the binding-protein-dependent transport system permease family
N5853_RS09905	COG0673	inositol 2-dehydrogenase activity
N5853_RS09920	COG1012	belongs to the aldehyde dehydrogenase family
N5853_RS09935	COG0673	inositol 2-dehydrogenase activity
N5853_RS09940	COG0673	inositol 2-dehydrogenase activity
N5853_RS09955	COG3718	enzyme involved in inositol metabolism
N5853_RS09960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5853_RS09965	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS09970	COG0673	inositol 2-dehydrogenase activity
N5853_RS09985	COG1609	Transcriptional regulator
N5853_RS10005	COG1674	ftsk spoiiie
N5853_RS10010	COG1252	NADH dehydrogenase
N5853_RS10015	COG2378	regulation of single-species biofilm formation
N5853_RS10025	COG2610	gluconate transmembrane transporter activity
N5853_RS10030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N5853_RS10075	COG0659	secondary active sulfate transmembrane transporter activity
N5853_RS10085	COG4977	sequence-specific DNA binding
N5853_RS10090	COG4650	regulator
N5853_RS10105	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N5853_RS10115	COG4208	sulfate ABC transporter
N5853_RS10120	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N5853_RS10130	COG2252	PERMEase
N5853_RS10145	COG4771	TonB-dependent receptor
N5853_RS10155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5853_RS10180	COG0625	glutathione transferase activity
N5853_RS10195	COG4783	chaperone-mediated protein folding
N5853_RS10210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N5853_RS10215	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N5853_RS10230	COG0384	phenazine biosynthesis protein PhzF
N5853_RS10240	COG1230	cation diffusion facilitator family transporter
N5853_RS10255	COG0242	peptide deformylase activity
N5853_RS10260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N5853_RS10275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N5853_RS10305	COG2391	methyltransferase activity
N5853_RS10320	COG1178	ABC-type Fe3 transport system permease component
N5853_RS10345	COG0489	protein tyrosine kinase activity
N5853_RS10370	COG1643	Atp-dependent helicase
N5853_RS10380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N5853_RS10385	COG0560	Phosphoserine phosphatase
N5853_RS10400	COG3448	diguanylate cyclase activity
N5853_RS10400	COG4175	Glycine betaine
N5853_RS10405	COG4176	ABC-type proline glycine betaine transport system permease component
N5853_RS10430	COG0028	Belongs to the TPP enzyme family
N5853_RS10440	COG1999	signal sequence binding
N5853_RS10450	COG0006	proline dipeptidase activity
N5853_RS10455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5853_RS10460	COG0009	L-threonylcarbamoyladenylate synthase
N5853_RS10465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N5853_RS10470	COG0440	acetolactate synthase activity
N5853_RS10475	COG0028	Belongs to the TPP enzyme family
N5853_RS10500	COG0574	Belongs to the PEP-utilizing enzyme family
N5853_RS10500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N5853_RS10510	COG0583	DNA-binding transcription factor activity
N5853_RS10570	COG1376	ErfK ybiS ycfS ynhG family protein
N5853_RS10575	COG1181	Belongs to the D-alanine--D-alanine ligase family
N5853_RS10585	COG0849	cell division
N5853_RS10600	COG1648	precorrin-2 dehydrogenase activity
N5853_RS10600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N5853_RS10610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5853_RS10620	COG3153	acetyltransferase
N5853_RS10650	COG4993	Dehydrogenase
N5853_RS10655	COG2171	N-acyltransferase activity
N5853_RS10665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N5853_RS10665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N5853_RS10670	COG1105	Belongs to the carbohydrate kinase PfkB family
N5853_RS10675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N5853_RS10675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N5853_RS10695	COG2807	transmembrane transport
N5853_RS10710	COG0400	carboxylic ester hydrolase activity
N5853_RS10725	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N5853_RS10730	COG0594	ribonuclease P activity
N5853_RS10740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N5853_RS10755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N5853_RS10765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N5853_RS10780	COG2857	Cytochrome c1
N5853_RS10780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N5853_RS10785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N5853_RS10790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N5853_RS10795	COG0012	GTP binding
N5853_RS10800	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N5853_RS10815	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
N5853_RS10820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N5853_RS10825	COG1268	BioY protein
N5853_RS10830	COG3338	carbonate dehydratase activity
N5853_RS10850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
N5853_RS10860	COG1278	Cold shock
N5853_RS10875	COG3655	Transcriptional regulator
N5853_RS10885	COG1120	ATPase activity
N5853_RS10890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5853_RS10895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N5853_RS10910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N5853_RS10915	COG0358	DNA primase activity
N5853_RS10925	COG0668	transmembrane transport
N5853_RS10940	COG0697	spore germination
N5853_RS10960	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N5853_RS10970	COG2824	Alkylphosphonate utilization operon protein PhnA
N5853_RS10985	COG1785	Belongs to the alkaline phosphatase family
N5853_RS11005	COG2022	thiamine diphosphate biosynthetic process
N5853_RS11025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N5853_RS11160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N5853_RS11185	COG1388	LysM domain
N5853_RS11185	COG1376	ErfK ybiS ycfS ynhG family protein
N5853_RS11195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N5853_RS11200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5853_RS11210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N5853_RS11215	COG0789	Transcriptional regulator
N5853_RS11220	COG1304	FMN binding
N5853_RS11235	COG2268	Band 7 protein
N5853_RS11240	COG0538	isocitrate dehydrogenase activity
N5853_RS11250	COG1250	3-hydroxyacyl-CoA dehydrogenase
N5853_RS11255	COG0753	catalase activity
N5853_RS11265	COG1570	exodeoxyribonuclease VII activity
N5853_RS11270	COG0519	Catalyzes the synthesis of GMP from XMP
N5853_RS11275	COG0004	ammonium transporteR
N5853_RS11280	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
N5853_RS11290	COG1522	sequence-specific DNA binding
N5853_RS11295	COG1609	Transcriptional regulator
N5853_RS11315	COG0825	malonyl-CoA metabolic process
N5853_RS11320	COG2867	negative regulation of translational initiation
N5853_RS11325	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N5853_RS11330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N5853_RS11335	COG0508	dehydrogenase complex catalyzes the overall conversion of
N5853_RS11340	COG0508	dehydrogenase complex catalyzes the overall conversion of
N5853_RS11340	COG0022	dehydrogenase e1 component
N5853_RS11345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N5853_RS11350	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N5853_RS11380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N5853_RS11390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N5853_RS11390	COG0195	Participates in both transcription termination and antitermination
N5853_RS11395	COG0779	Required for maturation of 30S ribosomal subunits
N5853_RS11405	COG0463	Glycosyl transferase, family 2
N5853_RS11415	COG0456	acetyltransferase
N5853_RS11430	COG0632	four-way junction helicase activity
N5853_RS11440	COG0824	Thioesterase
N5853_RS11445	COG1063	alcohol dehydrogenase
N5853_RS11450	COG2314	TM2 domain
N5853_RS11460	COG0066	3-isopropylmalate dehydratase activity
N5853_RS11470	COG1686	Belongs to the peptidase S11 family
N5853_RS11475	COG0589	response to stress
N5853_RS11490	COG3443	Belongs to the bacterial solute-binding protein 9 family
N5853_RS11500	COG2086	electron transfer activity
N5853_RS11505	COG0583	DNA-binding transcription factor activity
N5853_RS11530	COG3527	Alpha-acetolactate decarboxylase
N5853_RS11535	COG0583	DNA-binding transcription factor activity
N5853_RS11555	COG0471	metal ion transport
N5853_RS11565	COG0590	tRNA wobble adenosine to inosine editing
N5853_RS11585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N5853_RS11595	COG3118	belongs to the thioredoxin family
N5853_RS11600	COG1515	deoxyribonuclease V activity
N5853_RS11630	COG2252	PERMEase
N5853_RS11635	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N5853_RS11640	COG1785	Belongs to the alkaline phosphatase family
N5853_RS11650	COG1136	(ABC) transporter
N5853_RS11660	COG1522	sequence-specific DNA binding
N5853_RS11670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N5853_RS11685	COG1846	Transcriptional regulator
N5853_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS11710	COG0505	Belongs to the CarA family
N5853_RS11740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N5853_RS11760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N5853_RS11765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N5853_RS11770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N5853_RS11775	COG2326	polyphosphate kinase activity
N5853_RS11780	COG5002	protein histidine kinase activity
N5853_RS11790	COG0131	Imidazoleglycerol-phosphate dehydratase
N5853_RS11800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N5853_RS11840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N5853_RS11850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N5853_RS11855	COG4771	TonB-dependent receptor
N5853_RS11860	COG0477	Major facilitator Superfamily
N5853_RS11875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N5853_RS11880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N5853_RS11910	COG0156	8-amino-7-oxononanoate synthase activity
N5853_RS11915	COG0656	L-ascorbic acid biosynthetic process
N5853_RS11925	COG0248	Ppx GppA phosphatase
N5853_RS11965	COG0644	oxidoreductase
N5853_RS11970	COG0644	oxidoreductase
N5853_RS11975	COG0425	Belongs to the sulfur carrier protein TusA family
N5853_RS11980	COG3034	peptidoglycan biosynthetic process
N5853_RS11985	COG3034	peptidoglycan biosynthetic process
N5853_RS12035	COG1464	Belongs to the NlpA lipoprotein family
N5853_RS12040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N5853_RS12060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N5853_RS12065	COG1137	ATPase activity
N5853_RS12105	COG1301	dicarboxylic acid transport
N5853_RS12115	COG0667	Aldo Keto reductase
N5853_RS12125	COG1733	regulation of RNA biosynthetic process
N5853_RS12135	COG1172	Belongs to the binding-protein-dependent transport system permease family
N5853_RS12185	COG1126	abc transporter atp-binding protein
N5853_RS12215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5853_RS12225	COG3842	ATPase activity
N5853_RS12230	COG0395	ABC-type sugar transport system, permease component
N5853_RS12245	COG3030	protein affecting phage T7 exclusion by the F plasmid
N5853_RS12250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N5853_RS12285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N5853_RS12290	COG0259	pyridoxamine-phosphate oxidase activity
N5853_RS12300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N5853_RS12325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N5853_RS12330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
N5853_RS12335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N5853_RS12340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N5853_RS12355	COG0793	Belongs to the peptidase S41A family
N5853_RS12365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5853_RS12370	COG1946	Acyl-CoA thioesterase
N5853_RS12405	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N5853_RS12410	COG2835	tetraacyldisaccharide 4'-kinase activity
N5853_RS12415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N5853_RS12420	COG3135	benzoate transporter
N5853_RS12430	COG0612	Peptidase, M16
N5853_RS12435	COG0612	Peptidase, M16
N5853_RS12440	COG0742	ribosomal rna small subunit methyltransferase
N5853_RS12450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5853_RS12455	COG1131	(ABC) transporter
N5853_RS12460	COG0842	Transport permease protein
N5853_RS12465	COG0842	Transport permease protein
N5853_RS12480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N5853_RS12490	COG0659	secondary active sulfate transmembrane transporter activity
N5853_RS12495	COG0589	response to stress
N5853_RS12500	COG0473	3-isopropylmalate dehydrogenase activity
N5853_RS12510	COG3254	rhamnose metabolic process
N5853_RS12515	COG1172	Belongs to the binding-protein-dependent transport system permease family
N5853_RS12530	COG1879	ABC-type sugar transport system periplasmic component
N5853_RS12535	COG4952	isomerase
N5853_RS12550	COG1070	Carbohydrate kinase
N5853_RS12555	COG1063	alcohol dehydrogenase
N5853_RS12560	COG3347	Dehydrogenase
N5853_RS12560	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS12565	COG1349	DNA-binding transcription factor activity
N5853_RS12575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N5853_RS12585	COG1172	Belongs to the binding-protein-dependent transport system permease family
N5853_RS12595	COG1879	ABC-type sugar transport system periplasmic component
N5853_RS12610	COG0729	surface antigen
N5853_RS12625	COG0287	Prephenate dehydrogenase
N5853_RS12640	COG0508	dehydrogenase complex catalyzes the overall conversion of
N5853_RS12645	COG0567	Dehydrogenase, E1 component
N5853_RS12650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N5853_RS12665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N5853_RS12675	COG2346	COG2346, Truncated hemoglobins
N5853_RS12685	COG0745	RESPONSE REGULATOR receiver
N5853_RS12695	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
N5853_RS12700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N5853_RS12725	COG0531	amino acid
N5853_RS12735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N5853_RS12750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N5853_RS12790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N5853_RS12810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N5853_RS12820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N5853_RS12830	COG0142	geranyltranstransferase activity
N5853_RS12840	COG0339	signal peptide processing
N5853_RS12845	COG2239	Acts as a magnesium transporter
N5853_RS12875	COG2205	protein histidine kinase activity
N5853_RS12880	COG0745	RESPONSE REGULATOR receiver
N5853_RS12885	COG1846	Transcriptional regulator
N5853_RS12890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N5853_RS12895	COG0783	Belongs to the Dps family
N5853_RS12900	COG0217	transcriptional regulatory protein
N5853_RS12910	COG1760	l-serine dehydratase
N5853_RS12925	COG0842	Transport permease protein
N5853_RS12930	COG1129	ABC transporter
N5853_RS12930	COG0842	Transport permease protein
N5853_RS12935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5853_RS12940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N5853_RS12960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N5853_RS12965	COG3257	ureidoglycine aminohydrolase activity
N5853_RS12970	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N5853_RS12980	COG0019	diaminopimelate decarboxylase activity
N5853_RS12995	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N5853_RS13000	COG0033	Phosphoglucomutase
N5853_RS13010	COG1268	BioY protein
N5853_RS13045	COG0642	Histidine kinase
N5853_RS13065	COG1739	Uncharacterized protein family UPF0029
N5853_RS13070	COG2910	NAD(P)H-binding
N5853_RS13075	COG1733	regulation of RNA biosynthetic process
N5853_RS13085	COG0484	heat shock protein binding
N5853_RS13090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N5853_RS13095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N5853_RS13105	COG0006	proline dipeptidase activity
N5853_RS13110	COG1496	oxidoreductase activity
N5853_RS13120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N5853_RS13145	COG5328	Belongs to the UPF0262 family
N5853_RS13175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N5853_RS13180	COG1185	polyribonucleotide nucleotidyltransferase activity
N5853_RS13200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N5853_RS13205	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N5853_RS13210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N5853_RS13215	COG2813	Specifically methylates the guanine in position
N5853_RS13240	COG1473	amidohydrolase
N5853_RS13250	COG0717	Belongs to the dCTP deaminase family
N5853_RS13275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N5853_RS13290	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
N5853_RS13290	COG4932	domain protein
N5853_RS13290	COG3266	domain, Protein
N5853_RS13305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N5853_RS13315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N5853_RS13320	COG0765	amino acid transport
N5853_RS13325	COG1126	abc transporter atp-binding protein
N5853_RS13380	COG0501	Belongs to the peptidase M48B family
N5853_RS13385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N5853_RS13385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N5853_RS13395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N5853_RS13400	COG1663	tetraacyldisaccharide 4'-kinase activity
N5853_RS13405	COG1519	Transferase
N5853_RS13420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5853_RS13425	COG0577	efflux transmembrane transporter activity
N5853_RS13425	COG1136	(ABC) transporter
N5853_RS13440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N5853_RS13445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N5853_RS13450	COG0552	protein localization to endoplasmic reticulum
N5853_RS13465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N5853_RS13470	COG4569	acetaldehyde dehydrogenase (acetylating) activity
N5853_RS13480	COG1917	Cupin 2, conserved barrel domain protein
N5853_RS13495	COG3971	2-oxopent-4-enoate hydratase activity
N5853_RS13510	COG0583	DNA-binding transcription factor activity
N5853_RS13520	COG0559	Belongs to the binding-protein-dependent transport system permease family
N5853_RS13545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N5853_RS13550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N5853_RS13555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N5853_RS13560	COG1192	Involved in chromosome partitioning
N5853_RS13565	COG1475	DNA binding
N5853_RS13595	COG1696	Membrane protein involved in D-alanine export
N5853_RS13615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N5853_RS13620	COG1113	amino acid transport
N5853_RS13640	COG2271	Major facilitator Superfamily
N5853_RS13645	COG1448	Aminotransferase
N5853_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS13655	COG1574	metal-dependent hydrolase with the TIM-barrel fold
N5853_RS13660	COG0531	amino acid
N5853_RS13670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N5853_RS13680	COG2986	histidine ammonia-lyase
N5853_RS13685	COG1228	amidohydrolase
N5853_RS13700	COG1288	antiporter activity
N5853_RS13740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5853_RS13750	COG4608	Belongs to the ABC transporter superfamily
N5853_RS13755	COG0444	Belongs to the ABC transporter superfamily
N5853_RS13760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N5853_RS13765	COG0601	transmembrane transport
N5853_RS13770	COG0747	negative chemotaxis
N5853_RS13780	COG0747	negative chemotaxis
N5853_RS13785	COG1473	amidohydrolase
N5853_RS13790	COG1473	amidohydrolase
N5853_RS13820	COG0395	ABC-type sugar transport system, permease component
N5853_RS13825	COG1175	transmembrane transport
N5853_RS13840	COG2814	Major facilitator Superfamily
N5853_RS13855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N5853_RS13865	COG4770	biotin carboxylase activity
N5853_RS13870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N5853_RS13875	COG4336	lyase activity
N5853_RS13880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N5853_RS13885	COG1914	H( )-stimulated, divalent metal cation uptake system
N5853_RS13900	COG1126	abc transporter atp-binding protein
N5853_RS13905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N5853_RS13910	COG0765	amino acid transport
N5853_RS13915	COG0765	amino acid transport
N5853_RS13935	COG1063	alcohol dehydrogenase
N5853_RS13940	COG3800	Transcriptional regulator
N5853_RS13940	COG1396	sequence-specific DNA binding
N5853_RS13945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N5853_RS13950	COG4770	biotin carboxylase activity
N5853_RS13955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N5853_RS13955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N5853_RS13960	COG0346	lactoylglutathione lyase activity
N5853_RS13985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N5853_RS14010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N5853_RS14020	COG1082	Xylose isomerase domain protein TIM barrel
N5853_RS14025	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS14055	COG1116	anion transmembrane transporter activity
N5853_RS14065	COG2358	TRAP transporter, solute receptor (TAXI family
N5853_RS14075	COG1120	ATPase activity
N5853_RS14080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5853_RS14095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5853_RS14120	COG4774	siderophore transport
N5853_RS14125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5853_RS14130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5853_RS14135	COG4592	Periplasmic binding protein
N5853_RS14145	COG1120	ATPase activity
N5853_RS14150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N5853_RS14155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5853_RS14165	COG4771	TonB-dependent receptor
N5853_RS14175	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N5853_RS14190	COG1475	DNA binding
N5853_RS14195	COG1192	Involved in chromosome partitioning
N5853_RS14240	COG1132	(ABC) transporter
N5853_RS14245	COG1132	(ABC) transporter
N5853_RS14245	COG2375	cellular response to nickel ion
N5853_RS14255	COG4771	TonB-dependent receptor
N5853_RS14260	COG4771	TonB-dependent receptor
N5853_RS14280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N5853_RS14320	COG3609	addiction module antidote protein, CC2985 family
N5853_RS14340	COG2076	Multidrug Resistance protein
N5853_RS14355	COG0745	RESPONSE REGULATOR receiver
N5853_RS14360	COG3850	Histidine kinase
N5853_RS14360	COG5002	protein histidine kinase activity
N5853_RS14365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N5853_RS14370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5853_RS14375	COG1116	anion transmembrane transporter activity
N5853_RS14390	COG1268	BioY protein
N5853_RS14400	COG1091	dTDP-4-dehydrorhamnose reductase activity
N5853_RS14405	COG1088	dTDP-glucose 4,6-dehydratase activity
N5853_RS14455	COG0371	Dehydrogenase
N5853_RS14465	COG2814	Major facilitator Superfamily
N5853_RS14505	COG4120	Belongs to the binding-protein-dependent transport system permease family
N5853_RS14515	COG2188	Transcriptional regulator
N5853_RS14550	COG0683	leucine binding
N5853_RS14580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N5853_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
N5853_RS14605	COG1522	sequence-specific DNA binding
N5853_RS14620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N5853_RS14625	COG2313	pseudouridylate synthase activity
N5853_RS14630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5853_RS14650	COG4953	penicillin-binding protein 1C
N5853_RS14655	COG2373	Large extracellular alpha-helical protein
N5853_RS14665	COG2315	Protein conserved in bacteria