locus-tag	class	description
N6B01_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N6B01_RS00010	COG2890	protein-(glutamine-N5) methyltransferase activity
N6B01_RS00015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N6B01_RS00030	COG0488	(ABC) transporter
N6B01_RS00035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N6B01_RS00070	COG0174	glutamine synthetase
N6B01_RS00075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N6B01_RS00080	COG0519	Catalyzes the synthesis of GMP from XMP
N6B01_RS00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6B01_RS00125	COG0477	Major facilitator Superfamily
N6B01_RS00130	COG0028	Belongs to the TPP enzyme family
N6B01_RS00140	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N6B01_RS00160	COG0642	Histidine kinase
N6B01_RS00170	COG0604	alcohol dehydrogenase
N6B01_RS00190	COG3842	ATPase activity
N6B01_RS00195	COG1178	ABC-type Fe3 transport system permease component
N6B01_RS00230	COG0640	Transcriptional regulator
N6B01_RS00245	COG1737	Transcriptional regulator
N6B01_RS00255	COG1869	D-ribose catabolic process
N6B01_RS00265	COG1172	Belongs to the binding-protein-dependent transport system permease family
N6B01_RS00270	COG1129	ABC transporter
N6B01_RS00285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N6B01_RS00290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N6B01_RS00295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N6B01_RS00335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N6B01_RS00340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N6B01_RS00345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N6B01_RS00360	COG3750	Belongs to the UPF0335 family
N6B01_RS00385	COG0683	leucine binding
N6B01_RS00405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N6B01_RS00410	COG0697	spore germination
N6B01_RS00425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N6B01_RS00435	COG1132	(ABC) transporter
N6B01_RS00440	COG0285	dihydrofolate synthase activity
N6B01_RS00450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N6B01_RS00465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N6B01_RS00490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N6B01_RS00495	COG0527	aspartate kinase activity
N6B01_RS00510	COG0577	efflux transmembrane transporter activity
N6B01_RS00510	COG1136	(ABC) transporter
N6B01_RS00515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N6B01_RS00530	COG1519	Transferase
N6B01_RS00535	COG1663	tetraacyldisaccharide 4'-kinase activity
N6B01_RS00540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N6B01_RS00545	COG0602	queuosine metabolic process
N6B01_RS00550	COG0720	synthase
N6B01_RS00570	COG0277	FAD linked oxidase domain protein
N6B01_RS00580	COG3842	ATPase activity
N6B01_RS00585	COG1176	ABC-type spermidine putrescine transport system, permease component I
N6B01_RS00590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N6B01_RS00600	COG1304	FMN binding
N6B01_RS00655	COG0484	heat shock protein binding
N6B01_RS00660	COG0443	Heat shock 70 kDa protein
N6B01_RS00665	COG1473	amidohydrolase
N6B01_RS00680	COG2951	lytic endotransglycosylase activity
N6B01_RS00690	COG2358	TRAP transporter, solute receptor (TAXI family
N6B01_RS00700	COG1116	anion transmembrane transporter activity
N6B01_RS00710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N6B01_RS00720	COG2902	Dehydrogenase
N6B01_RS00725	COG0288	reversible hydration of carbon dioxide
N6B01_RS00730	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
N6B01_RS00755	COG1012	belongs to the aldehyde dehydrogenase family
N6B01_RS00765	COG2086	electron transfer activity
N6B01_RS00790	COG1177	transmembrane transport
N6B01_RS00800	COG3842	ATPase activity
N6B01_RS00805	COG1074	ATP-dependent DNA helicase activity
N6B01_RS00810	COG2887	Belongs to the helicase family. UvrD subfamily
N6B01_RS00815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N6B01_RS00820	COG2813	Specifically methylates the guanine in position
N6B01_RS00825	COG1473	amidohydrolase
N6B01_RS00855	COG2072	flavoprotein involved in K transport
N6B01_RS00875	COG0583	DNA-binding transcription factor activity
N6B01_RS00880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N6B01_RS00885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N6B01_RS00890	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
N6B01_RS00895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N6B01_RS00910	COG0730	response to heat
N6B01_RS00920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N6B01_RS00930	COG0259	pyridoxamine-phosphate oxidase activity
N6B01_RS00935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N6B01_RS00985	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N6B01_RS00990	COG3030	protein affecting phage T7 exclusion by the F plasmid
N6B01_RS01000	COG1175	transmembrane transport
N6B01_RS01005	COG0395	ABC-type sugar transport system, permease component
N6B01_RS01010	COG3842	ATPase activity
N6B01_RS01025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N6B01_RS01055	COG3588	fructose-bisphosphate aldolase
N6B01_RS01070	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N6B01_RS01075	COG1137	ATPase activity
N6B01_RS01115	COG1301	dicarboxylic acid transport
N6B01_RS01125	COG0667	Aldo Keto reductase
N6B01_RS01130	COG2011	ABC-type metal ion transport system permease component
N6B01_RS01135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N6B01_RS01180	COG0339	signal peptide processing
N6B01_RS01185	COG2239	Acts as a magnesium transporter
N6B01_RS01200	COG0469	pyruvate kinase activity
N6B01_RS01210	COG0672	)-iron permease
N6B01_RS01235	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6B01_RS01245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N6B01_RS01255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N6B01_RS01295	COG0784	Response regulator, receiver
N6B01_RS01310	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N6B01_RS01315	COG2202	Pas domain
N6B01_RS01315	COG3920	Histidine kinase
N6B01_RS01330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N6B01_RS01355	COG1760	l-serine dehydratase
N6B01_RS01365	COG0033	Phosphoglucomutase
N6B01_RS01370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N6B01_RS01385	COG0019	diaminopimelate decarboxylase activity
N6B01_RS01390	COG3257	ureidoglycine aminohydrolase activity
N6B01_RS01395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N6B01_RS01415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N6B01_RS01425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N6B01_RS01430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
N6B01_RS01465	COG1063	alcohol dehydrogenase
N6B01_RS01475	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N6B01_RS01485	COG0248	Ppx GppA phosphatase
N6B01_RS01525	COG0644	oxidoreductase
N6B01_RS01530	COG0644	oxidoreductase
N6B01_RS01535	COG0425	Belongs to the sulfur carrier protein TusA family
N6B01_RS01545	COG3034	peptidoglycan biosynthetic process
N6B01_RS01565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N6B01_RS01570	COG0037	tRNA processing
N6B01_RS01580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N6B01_RS01600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N6B01_RS01605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N6B01_RS01610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N6B01_RS01615	COG1845	cytochrome c oxidase, subunit III
N6B01_RS01620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N6B01_RS01625	COG1620	l-lactate permease
N6B01_RS01630	COG2186	Transcriptional regulator
N6B01_RS01635	COG1304	FMN binding
N6B01_RS01655	COG1218	3'(2'),5'-bisphosphate nucleotidase
N6B01_RS01660	COG2226	methyltransferase
N6B01_RS01665	COG1040	competence protein
N6B01_RS01670	COG0792	nuclease activity
N6B01_RS01675	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N6B01_RS01680	COG0436	Aminotransferase
N6B01_RS01695	COG1120	ATPase activity
N6B01_RS01700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N6B01_RS01735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N6B01_RS01735	COG2111	Na H antiporter
N6B01_RS01740	COG1006	Multisubunit Na H antiporter MnhC subunit
N6B01_RS01745	COG0651	ATP synthesis coupled electron transport
N6B01_RS01750	COG1863	multisubunit Na H antiporter MnhE subunit
N6B01_RS01755	COG2212	antiporter activity
N6B01_RS01760	COG1320	monovalent cation:proton antiporter activity
N6B01_RS01765	COG1376	ErfK ybiS ycfS ynhG family protein
N6B01_RS01775	COG0471	metal ion transport
N6B01_RS01780	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N6B01_RS01785	COG0583	DNA-binding transcription factor activity
N6B01_RS01795	COG1970	mechanosensitive ion channel activity
N6B01_RS01805	COG0754	glutathionylspermidine amidase activity
N6B01_RS01810	COG5463	Belongs to the UPF0441 family
N6B01_RS01815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N6B01_RS01820	COG1702	phosphate starvation-inducible protein PhoH
N6B01_RS01830	COG4535	Mg2 and Co2 transporter CorC
N6B01_RS01835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N6B01_RS01840	COG1396	sequence-specific DNA binding
N6B01_RS01845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N6B01_RS01865	COG0802	atpase or kinase
N6B01_RS01870	COG2205	protein histidine kinase activity
N6B01_RS01910	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N6B01_RS01930	COG0670	Belongs to the BI1 family
N6B01_RS01935	COG4181	ATPase activity
N6B01_RS02015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N6B01_RS02020	COG0351	phosphomethylpyrimidine kinase
N6B01_RS02025	COG0477	Major facilitator Superfamily
N6B01_RS02030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N6B01_RS02050	COG0181	hydroxymethylbilane synthase activity
N6B01_RS02055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N6B01_RS02075	COG2271	Major facilitator Superfamily
N6B01_RS02080	COG0697	spore germination
N6B01_RS02085	COG2186	Transcriptional regulator
N6B01_RS02090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N6B01_RS02095	COG1012	belongs to the aldehyde dehydrogenase family
N6B01_RS02115	COG0305	Participates in initiation and elongation during chromosome replication
N6B01_RS02155	COG3477	response to acidic pH
N6B01_RS02170	COG2885	chlorophyll binding
N6B01_RS02175	COG4974	Belongs to the 'phage' integrase family
N6B01_RS02190	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
N6B01_RS02210	COG2840	Smr protein MutS2
N6B01_RS02220	COG0159	tryptophan synthase activity
N6B01_RS02240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6B01_RS02260	COG0151	Belongs to the GarS family
N6B01_RS02265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N6B01_RS02285	COG2884	Cell division ATP-binding protein ftsE
N6B01_RS02300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N6B01_RS02310	COG1522	sequence-specific DNA binding
N6B01_RS02320	COG1136	(ABC) transporter
N6B01_RS02330	COG1785	Belongs to the alkaline phosphatase family
N6B01_RS02335	COG2252	PERMEase
N6B01_RS02340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N6B01_RS02350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N6B01_RS02355	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
N6B01_RS02375	COG3118	belongs to the thioredoxin family
N6B01_RS02405	COG0590	tRNA wobble adenosine to inosine editing
N6B01_RS02415	COG0471	metal ion transport
N6B01_RS02440	COG0583	DNA-binding transcription factor activity
N6B01_RS02470	COG0583	DNA-binding transcription factor activity
N6B01_RS02475	COG2086	electron transfer activity
N6B01_RS02485	COG0583	DNA-binding transcription factor activity
N6B01_RS02490	COG1960	acyl-CoA dehydrogenase activity
N6B01_RS02495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N6B01_RS02500	COG1250	3-hydroxyacyl-CoA dehydrogenase
N6B01_RS02505	COG3443	Belongs to the bacterial solute-binding protein 9 family
N6B01_RS02520	COG0589	response to stress
N6B01_RS02525	COG1686	Belongs to the peptidase S11 family
N6B01_RS02535	COG0066	3-isopropylmalate dehydratase activity
N6B01_RS02550	COG0604	alcohol dehydrogenase
N6B01_RS02550	COG3321	synthase
N6B01_RS02565	COG0824	Thioesterase
N6B01_RS02575	COG0632	four-way junction helicase activity
N6B01_RS02585	COG2720	vancomycin resistance protein
N6B01_RS02620	COG1214	PFAM Peptidase M22, glycoprotease
N6B01_RS02625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N6B01_RS02635	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N6B01_RS02640	COG0642	Histidine kinase
N6B01_RS02645	COG0745	RESPONSE REGULATOR receiver
N6B01_RS02675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N6B01_RS02690	COG0523	cobalamin synthesis protein
N6B01_RS02695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N6B01_RS02705	COG2205	protein histidine kinase activity
N6B01_RS02710	COG2084	Dehydrogenase
N6B01_RS02715	COG4771	TonB-dependent receptor
N6B01_RS02720	COG2819	hydrolase of the alpha beta superfamily
N6B01_RS02725	COG4607	ABC-type enterochelin transport system periplasmic component
N6B01_RS02730	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N6B01_RS02735	COG4605	iron ion homeostasis
N6B01_RS02740	COG4604	ABC transporter, ATP-binding protein
N6B01_RS02750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N6B01_RS02765	COG0697	spore germination
N6B01_RS02790	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N6B01_RS02820	COG1309	transcriptional regulator
N6B01_RS02840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N6B01_RS02845	COG0193	aminoacyl-tRNA hydrolase activity
N6B01_RS02850	COG3158	transport of potassium into the cell
N6B01_RS02855	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N6B01_RS02865	COG2226	methyltransferase
N6B01_RS02875	COG3047	cAMP biosynthetic process
N6B01_RS02890	COG0471	metal ion transport
N6B01_RS02890	COG3273	potassium ion transport
N6B01_RS02905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N6B01_RS02915	COG4149	molybdate abc transporter
N6B01_RS02920	COG0157	Belongs to the NadC ModD family
N6B01_RS02940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N6B01_RS02960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N6B01_RS02970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N6B01_RS02975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N6B01_RS02975	COG2813	Specifically methylates the guanine in position
N6B01_RS03005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N6B01_RS03030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N6B01_RS03040	COG0131	Imidazoleglycerol-phosphate dehydratase
N6B01_RS03050	COG5002	protein histidine kinase activity
N6B01_RS03055	COG2326	polyphosphate kinase activity
N6B01_RS03060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6B01_RS03065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N6B01_RS03070	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N6B01_RS03090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N6B01_RS03130	COG2268	Band 7 protein
N6B01_RS03135	COG0482	sulfurtransferase activity
N6B01_RS03145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N6B01_RS03150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N6B01_RS03150	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
N6B01_RS03160	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N6B01_RS03175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N6B01_RS03200	COG3654	unkown
N6B01_RS03205	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N6B01_RS03210	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N6B01_RS03250	COG3738	Protein conserved in bacteria
N6B01_RS03255	COG0735	belongs to the Fur family
N6B01_RS03270	COG1733	regulation of RNA biosynthetic process
N6B01_RS03275	COG2910	NAD(P)H-binding
N6B01_RS03280	COG1846	Transcriptional regulator
N6B01_RS03290	COG0523	cobalamin synthesis protein
N6B01_RS03300	COG1902	pentaerythritol trinitrate reductase activity
N6B01_RS03305	COG2183	response to ionizing radiation
N6B01_RS03325	COG1525	nuclease
N6B01_RS03330	COG1132	(ABC) transporter
N6B01_RS03340	COG0546	phosphoglycolate phosphatase activity
N6B01_RS03350	COG1063	alcohol dehydrogenase
N6B01_RS03365	COG2095	MarC family integral membrane protein
N6B01_RS03375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N6B01_RS03380	COG4774	siderophore transport
N6B01_RS03385	COG2207	Transcriptional regulator
N6B01_RS03390	COG1120	ATPase activity
N6B01_RS03395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N6B01_RS03400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N6B01_RS03415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N6B01_RS03420	COG0343	queuine tRNA-ribosyltransferase activity
N6B01_RS03435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6B01_RS03515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N6B01_RS03535	COG0142	geranyltranstransferase activity
N6B01_RS03550	COG0751	glycine-tRNA ligase activity
N6B01_RS03555	COG0823	Involved in the tonB-independent uptake of proteins
N6B01_RS03555	COG1506	peptidase
N6B01_RS03560	COG2847	Copper chaperone PCu(A)C
N6B01_RS03570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N6B01_RS03585	COG0571	ribonuclease III activity
N6B01_RS03590	COG0681	Belongs to the peptidase S26 family
N6B01_RS03605	COG0521	Mo-molybdopterin cofactor biosynthetic process
N6B01_RS03610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N6B01_RS03615	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
N6B01_RS03620	COG0535	radical SAM domain protein
N6B01_RS03625	COG0535	radical SAM domain protein
N6B01_RS03630	COG0163	prenyltransferase activity
N6B01_RS03635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N6B01_RS03640	COG3154	lipid carrier protein
N6B01_RS03645	COG0826	peptidase U32
N6B01_RS03660	COG4993	Dehydrogenase
N6B01_RS03690	COG0714	Associated with various cellular activities
N6B01_RS03715	COG0494	nUDIX hydrolase
N6B01_RS03720	COG0740	serine-type endopeptidase activity
N6B01_RS03725	COG3152	Membrane
N6B01_RS03740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N6B01_RS03755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N6B01_RS03760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N6B01_RS03780	COG3023	N-Acetylmuramoyl-L-alanine amidase
N6B01_RS03785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N6B01_RS03815	COG0625	glutathione transferase activity
N6B01_RS03825	COG3852	Histidine kinase
N6B01_RS03830	COG2204	response regulator
N6B01_RS03835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N6B01_RS03845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N6B01_RS03860	COG0081	regulation of translation
N6B01_RS03870	COG0222	ribosome binding
N6B01_RS03880	COG0085	RNA polymerase activity
N6B01_RS03885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N6B01_RS03900	COG2202	Pas domain
N6B01_RS03900	COG2205	protein histidine kinase activity
N6B01_RS03910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N6B01_RS03910	COG0519	Catalyzes the synthesis of GMP from XMP
N6B01_RS03920	COG0433	COG0433 Predicted ATPase
N6B01_RS03940	COG1653	transport
N6B01_RS03945	COG0395	ABC-type sugar transport system, permease component
N6B01_RS03950	COG1175	transmembrane transport
N6B01_RS03955	COG3842	ATPase activity
N6B01_RS03960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N6B01_RS03965	COG1966	Carbon starvation protein
N6B01_RS03970	COG2879	small protein
N6B01_RS03975	COG0523	cobalamin synthesis protein
N6B01_RS03985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N6B01_RS03990	COG1780	Probably involved in ribonucleotide reductase function
N6B01_RS03995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N6B01_RS04005	COG1758	RNA polymerase activity
N6B01_RS04020	COG2223	nitrite transmembrane transporter activity
N6B01_RS04025	COG0741	lytic transglycosylase activity
N6B01_RS04040	COG0251	oxidation-reduction process
N6B01_RS04055	COG0431	NADPH-dependent FMN reductase
N6B01_RS04080	COG0556	nucleotide-excision repair
N6B01_RS04085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N6B01_RS04105	COG2195	Cleaves the N-terminal amino acid of tripeptides
N6B01_RS04110	COG0747	negative chemotaxis
N6B01_RS04120	COG0667	Aldo Keto reductase
N6B01_RS04125	COG0789	Transcriptional regulator
N6B01_RS04135	COG1194	a g-specific adenine glycosylase
N6B01_RS04140	COG0187	DNA topoisomerase II activity
N6B01_RS04145	COG0321	lipoyl(octanoyl) transferase activity
N6B01_RS04155	COG0194	GDP metabolic process
N6B01_RS04160	COG1492	cobalamin metabolic process
N6B01_RS04165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N6B01_RS04180	COG1278	Cold shock
N6B01_RS04190	COG1678	Uncharacterized ACR, COG1678
N6B01_RS04210	COG0745	RESPONSE REGULATOR receiver
N6B01_RS04235	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N6B01_RS04250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N6B01_RS04260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N6B01_RS04265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6B01_RS04270	COG1183	phosphatidylcholine synthase activity
N6B01_RS04280	COG1686	Belongs to the peptidase S11 family
N6B01_RS04295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N6B01_RS04300	COG0084	hydrolase, TatD family'
N6B01_RS04305	COG0321	lipoyl(octanoyl) transferase activity
N6B01_RS04305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N6B01_RS04310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N6B01_RS04350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N6B01_RS04355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N6B01_RS04360	COG0544	peptidyl-prolyl cis-trans isomerase activity
N6B01_RS04380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N6B01_RS04385	COG0248	Ppx GppA phosphatase
N6B01_RS04390	COG0312	modulator of DNA gyrase
N6B01_RS04400	COG0513	Belongs to the DEAD box helicase family
N6B01_RS04405	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N6B01_RS04425	COG4957	zinc ion binding
N6B01_RS04430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N6B01_RS04435	COG1132	(ABC) transporter
N6B01_RS04440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N6B01_RS04460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N6B01_RS04465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N6B01_RS04475	COG3720	iron ion transport
N6B01_RS04495	COG4178	(ABC) transporter
N6B01_RS04520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N6B01_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
N6B01_RS04530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N6B01_RS04550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N6B01_RS04555	COG0360	Binds together with S18 to 16S ribosomal RNA
N6B01_RS04560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N6B01_RS04560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N6B01_RS04565	COG0347	Belongs to the P(II) protein family
N6B01_RS04570	COG0174	glutamine synthetase
N6B01_RS04590	COG1530	ribonuclease E activity
N6B01_RS04595	COG0860	N-Acetylmuramoyl-L-alanine amidase
N6B01_RS04600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N6B01_RS04615	COG0785	Cytochrome C biogenesis protein
N6B01_RS04620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N6B01_RS04630	COG1722	exodeoxyribonuclease VII activity
N6B01_RS04635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N6B01_RS04635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N6B01_RS04655	COG0024	Methionine aminopeptidase
N6B01_RS04670	COG1278	Cold shock
N6B01_RS04695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N6B01_RS04755	COG0483	inositol monophosphate 1-phosphatase activity
N6B01_RS04765	COG0071	Belongs to the small heat shock protein (HSP20) family
N6B01_RS04775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N6B01_RS04780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N6B01_RS04780	COG0512	Glutamine amidotransferase of anthranilate synthase
N6B01_RS04790	COG1278	Cold shock
N6B01_RS04810	COG1494	fructose-1,6-bisphosphatase
N6B01_RS04820	COG0436	Aminotransferase
N6B01_RS04840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N6B01_RS04845	COG0758	DNA mediated transformation
N6B01_RS04855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N6B01_RS04855	COG1754	DNA topoisomerase type I activity
N6B01_RS04860	COG0557	exoribonuclease II activity
N6B01_RS04865	COG0477	Major facilitator Superfamily
N6B01_RS04870	COG0277	FAD linked oxidase domain protein
N6B01_RS04875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N6B01_RS04880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N6B01_RS04885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N6B01_RS04890	COG0356	it plays a direct role in the translocation of protons across the membrane
N6B01_RS04905	COG1160	GTP binding
N6B01_RS04915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N6B01_RS04925	COG0243	molybdopterin cofactor binding
N6B01_RS04935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N6B01_RS04940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N6B01_RS04945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N6B01_RS04950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N6B01_RS04955	COG0805	protein transport
N6B01_RS04965	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N6B01_RS04970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N6B01_RS04975	COG1388	LysM domain
N6B01_RS04975	COG4942	peptidase
N6B01_RS04980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N6B01_RS04990	COG0314	molybdopterin synthase activity
N6B01_RS05000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N6B01_RS05005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N6B01_RS05015	COG0105	UTP biosynthetic process
N6B01_RS05020	COG0488	(ABC) transporter
N6B01_RS05035	COG2151	metal-sulfur cluster biosynthetic enzyme
N6B01_RS05040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N6B01_RS05045	COG0719	Fe-S assembly protein
N6B01_RS05050	COG0396	ATPase activity
N6B01_RS05055	COG0719	Fe-S assembly protein
N6B01_RS05060	COG1104	cysteine desulfurase activity
N6B01_RS05065	COG2945	thiolester hydrolase activity
N6B01_RS05080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N6B01_RS05085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N6B01_RS05105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N6B01_RS05110	COG2274	protein secretion by the type I secretion system
N6B01_RS05125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N6B01_RS05130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N6B01_RS05135	COG0022	dehydrogenase e1 component
N6B01_RS05135	COG0508	dehydrogenase complex catalyzes the overall conversion of
N6B01_RS05140	COG0508	dehydrogenase complex catalyzes the overall conversion of
N6B01_RS05145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N6B01_RS05150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N6B01_RS05155	COG2867	negative regulation of translational initiation
N6B01_RS05160	COG0538	isocitrate dehydrogenase activity
N6B01_RS05190	COG2204	response regulator
N6B01_RS05205	COG1585	Membrane protein implicated in regulation of membrane protease activity
N6B01_RS05210	COG0330	HflC and HflK could
N6B01_RS05215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N6B01_RS05230	COG0303	'Molybdopterin
N6B01_RS05235	COG0315	cyclic pyranopterin monophosphate synthase activity
N6B01_RS05245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N6B01_RS05285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N6B01_RS05290	COG0109	protoheme IX farnesyltransferase activity
N6B01_RS05300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N6B01_RS05305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N6B01_RS05315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N6B01_RS05330	COG2828	Protein conserved in bacteria
N6B01_RS05335	COG0583	DNA-binding transcription factor activity
N6B01_RS05345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N6B01_RS05350	COG0052	Belongs to the universal ribosomal protein uS2 family
N6B01_RS05365	COG0740	serine-type endopeptidase activity
N6B01_RS05375	COG0569	domain protein
N6B01_RS05380	COG2204	response regulator
N6B01_RS05385	COG5000	phosphorelay sensor kinase activity
N6B01_RS05390	COG1959	2 iron, 2 sulfur cluster binding
N6B01_RS05395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N6B01_RS05395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N6B01_RS05415	COG4585	Histidine kinase
N6B01_RS05420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N6B01_RS05430	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N6B01_RS05440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N6B01_RS05445	COG0215	cysteine-tRNA ligase activity
N6B01_RS05460	COG1028	Short-chain dehydrogenase reductase Sdr
N6B01_RS05470	COG1764	response to oxidative stress
N6B01_RS05475	COG0308	aminopeptidase N
N6B01_RS05485	COG1573	uracil-dna glycosylase
N6B01_RS05490	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
N6B01_RS05505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N6B01_RS05540	COG0596	Alpha beta hydrolase
N6B01_RS05550	COG3189	MarR family transcriptional regulator
N6B01_RS05560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N6B01_RS05575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N6B01_RS05585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N6B01_RS05590	COG3835	regulator
N6B01_RS05595	COG1126	abc transporter atp-binding protein
N6B01_RS05600	COG0765	amino acid transport
N6B01_RS05605	COG4597	amino acid ABC transporter
N6B01_RS05610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6B01_RS05615	COG0626	cystathionine gamma-synthase activity
N6B01_RS05625	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N6B01_RS05640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N6B01_RS05650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N6B01_RS05650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N6B01_RS05660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N6B01_RS05680	COG0372	Belongs to the citrate synthase family
N6B01_RS05700	COG2003	Belongs to the UPF0758 family
N6B01_RS05705	COG0024	Methionine aminopeptidase
N6B01_RS05710	COG1489	DNA binding
N6B01_RS05715	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N6B01_RS05720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N6B01_RS05730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N6B01_RS05735	COG2181	nitrate reductase activity
N6B01_RS05740	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
N6B01_RS05745	COG1140	nitrate reductase beta subunit
N6B01_RS05750	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
N6B01_RS05755	COG2223	nitrite transmembrane transporter activity
N6B01_RS05785	COG0633	Ferredoxin
N6B01_RS05800	COG1797	cobyrinic acid a,c-diamide synthase activity
N6B01_RS05805	COG2814	Major facilitator Superfamily
N6B01_RS05820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N6B01_RS05825	COG0745	RESPONSE REGULATOR receiver
N6B01_RS05835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N6B01_RS05840	COG0531	amino acid
N6B01_RS05850	COG1612	heme a metabolic process
N6B01_RS05855	COG0113	porphobilinogen synthase activity
N6B01_RS05870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N6B01_RS05875	COG0037	tRNA processing
N6B01_RS05880	COG1113	amino acid transport
N6B01_RS05900	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N6B01_RS05905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N6B01_RS05910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N6B01_RS05915	COG0546	phosphoglycolate phosphatase activity
N6B01_RS05925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N6B01_RS05935	COG4166	transmembrane transport
N6B01_RS05945	COG2885	chlorophyll binding
N6B01_RS05950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N6B01_RS05955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N6B01_RS05990	COG1522	sequence-specific DNA binding
N6B01_RS06005	COG0728	peptidoglycan biosynthetic process
N6B01_RS06030	COG0436	Aminotransferase
N6B01_RS06035	COG0501	Belongs to the peptidase M48B family
N6B01_RS06045	COG0511	ligase activity, forming carbon-carbon bonds
N6B01_RS06055	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N6B01_RS06065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N6B01_RS06070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N6B01_RS06075	COG0149	triose-phosphate isomerase activity
N6B01_RS06085	COG3381	protein complex oligomerization
N6B01_RS06100	COG0528	UMP kinase activity
N6B01_RS06105	COG0233	cytoplasmic translational termination
N6B01_RS06125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N6B01_RS06130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N6B01_RS06140	COG2226	methyltransferase
N6B01_RS06155	COG2610	gluconate transmembrane transporter activity
N6B01_RS06160	COG3265	gluconokinase activity
N6B01_RS06165	COG0180	Tryptophanyl-tRNA synthetase
N6B01_RS06170	COG3218	ABC-type transport auxiliary lipoprotein component
N6B01_RS06170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N6B01_RS06180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N6B01_RS06180	COG3218	ABC-type transport auxiliary lipoprotein component
N6B01_RS06190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N6B01_RS06200	COG0280	phosphate acetyltransferase
N6B01_RS06200	COG0281	malic enzyme
N6B01_RS06205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N6B01_RS06210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6B01_RS06215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6B01_RS06230	COG2875	Belongs to the precorrin methyltransferase family
N6B01_RS06255	COG1862	Preprotein translocase
N6B01_RS06265	COG0746	molybdenum cofactor guanylyltransferase activity
N6B01_RS06275	COG0625	glutathione transferase activity
N6B01_RS06285	COG1573	uracil-dna glycosylase
N6B01_RS06300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N6B01_RS06310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6B01_RS06320	COG0765	amino acid transport
N6B01_RS06325	COG0765	amino acid transport
N6B01_RS06330	COG1126	abc transporter atp-binding protein
N6B01_RS06335	COG3938	Belongs to the proline racemase family
N6B01_RS06350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N6B01_RS06355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N6B01_RS06380	COG3106	COG3106 Predicted ATPase
N6B01_RS06385	COG0316	Belongs to the HesB IscA family
N6B01_RS06400	COG1686	Belongs to the peptidase S11 family
N6B01_RS06420	COG0277	FAD linked oxidase domain protein
N6B01_RS06430	COG2897	thiosulfate sulfurtransferase activity
N6B01_RS06465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N6B01_RS06475	COG1957	nucleoside hydrolase
N6B01_RS06480	COG0477	Major facilitator Superfamily
N6B01_RS06515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N6B01_RS06525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N6B01_RS06535	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N6B01_RS06545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N6B01_RS06550	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N6B01_RS06555	COG0750	zinc metalloprotease
N6B01_RS06575	COG0316	Belongs to the HesB IscA family
N6B01_RS06585	COG3180	Ammonia monooxygenase
N6B01_RS06590	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N6B01_RS06620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N6B01_RS06625	COG0537	adenosine 5'-monophosphoramidase activity
N6B01_RS06635	COG1126	abc transporter atp-binding protein
N6B01_RS06640	COG0765	amino acid transport
N6B01_RS06645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6B01_RS06675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N6B01_RS06685	COG0628	permease
N6B01_RS06695	COG0612	Peptidase, M16
N6B01_RS06705	COG0196	riboflavin kinase activity
N6B01_RS06710	COG3577	Aspartyl protease
N6B01_RS06715	COG3088	subunit of a heme lyase
N6B01_RS06720	COG1138	Cytochrome C-type biogenesis protein
N6B01_RS06725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N6B01_RS06740	COG1064	alcohol dehydrogenase
N6B01_RS06760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6B01_RS06820	COG2855	membrane
N6B01_RS06830	COG0200	Binds to the 23S rRNA
N6B01_RS06840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N6B01_RS06850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N6B01_RS06860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N6B01_RS06865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N6B01_RS06870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N6B01_RS06875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N6B01_RS06890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N6B01_RS06905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N6B01_RS06920	COG0088	Forms part of the polypeptide exit tunnel
N6B01_RS06925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N6B01_RS06935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N6B01_RS06950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N6B01_RS06970	COG0765	amino acid transport
N6B01_RS06975	COG0765	amino acid transport
N6B01_RS06980	COG1126	abc transporter atp-binding protein
N6B01_RS06995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6B01_RS07010	COG1012	belongs to the aldehyde dehydrogenase family
N6B01_RS07015	COG3108	Peptidase M15
N6B01_RS07035	COG1196	nuclear chromosome segregation
N6B01_RS07045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N6B01_RS07080	COG0067	glutamate synthase
N6B01_RS07080	COG0069	glutamate synthase activity
N6B01_RS07080	COG0070	glutamate synthase
N6B01_RS07090	COG0025	NhaP-type Na H and K H
N6B01_RS07100	COG2166	iron-sulfur cluster assembly
N6B01_RS07130	COG2895	sulfate adenylyltransferase (ATP) activity
N6B01_RS07140	COG0175	sulfate reduction
N6B01_RS07155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N6B01_RS07175	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N6B01_RS07205	COG3956	TIGRFAM MazG family protein
N6B01_RS07210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N6B01_RS07235	COG1253	flavin adenine dinucleotide binding
N6B01_RS07255	COG0617	tRNA 3'-terminal CCA addition
N6B01_RS07265	COG0714	Associated with various cellular activities
N6B01_RS07290	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N6B01_RS07295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N6B01_RS07320	COG2814	Major facilitator Superfamily
N6B01_RS07325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N6B01_RS07355	COG0420	3'-5' exonuclease activity
N6B01_RS07360	COG4717	serine-type aminopeptidase activity
N6B01_RS07365	COG2189	Belongs to the N(4) N(6)-methyltransferase family
N6B01_RS07385	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N6B01_RS07400	COG2205	protein histidine kinase activity
N6B01_RS07415	COG1309	transcriptional regulator
N6B01_RS07450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N6B01_RS07460	COG1832	CoA-binding protein
N6B01_RS07465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N6B01_RS07470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N6B01_RS07480	COG1346	cytolysis
N6B01_RS07485	COG1380	Effector of murein hydrolase LrgA
N6B01_RS07490	COG0583	DNA-binding transcription factor activity
N6B01_RS07505	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N6B01_RS07510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N6B01_RS07515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N6B01_RS07525	COG0784	Response regulator, receiver
N6B01_RS07530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N6B01_RS07555	COG0202	RNA polymerase activity
N6B01_RS07565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N6B01_RS07570	COG0563	adenylate kinase activity
N6B01_RS07575	COG0201	protein transport
N6B01_RS07580	COG0513	Belongs to the DEAD box helicase family
N6B01_RS07590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N6B01_RS07615	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N6B01_RS07615	COG3264	Mechanosensitive ion channel
N6B01_RS07630	COG4651	solute:proton antiporter activity
N6B01_RS07630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N6B01_RS07655	COG0776	regulation of translation
N6B01_RS07660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N6B01_RS07690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N6B01_RS07695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N6B01_RS07710	COG2239	Acts as a magnesium transporter
N6B01_RS07725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N6B01_RS07735	COG3676	manually curated
N6B01_RS07745	COG1183	phosphatidylcholine synthase activity
N6B01_RS07750	COG0688	phosphatidylethanolamine metabolic process
N6B01_RS07755	COG5265	(ABC) transporter
N6B01_RS07760	COG1652	LysM domain
N6B01_RS07760	COG2823	Periplasmic or secreted lipoprotein
N6B01_RS07765	COG1611	Belongs to the LOG family
N6B01_RS07780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N6B01_RS07795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N6B01_RS07805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N6B01_RS07815	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
N6B01_RS07860	COG0504	CTP synthase activity
N6B01_RS07875	COG0148	phosphopyruvate hydratase activity
N6B01_RS07880	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N6B01_RS07890	COG1121	(ABC) transporter
N6B01_RS07895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N6B01_RS07900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N6B01_RS07905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N6B01_RS07930	COG1252	NADH dehydrogenase
N6B01_RS07935	COG2378	regulation of single-species biofilm formation
N6B01_RS07950	COG2207	Transcriptional regulator
N6B01_RS07960	COG1007	ATP synthesis coupled electron transport
N6B01_RS07975	COG0713	ATP synthesis coupled electron transport
N6B01_RS07985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6B01_RS07990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N6B01_RS08000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N6B01_RS08005	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
N6B01_RS08010	COG0649	NAD binding
N6B01_RS08025	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6B01_RS08030	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N6B01_RS08060	COG1546	Belongs to the CinA family
N6B01_RS08060	COG1058	Belongs to the CinA family
N6B01_RS08085	COG1674	ftsk spoiiie
N6B01_RS08130	COG0659	secondary active sulfate transmembrane transporter activity
N6B01_RS08135	COG4650	regulator
N6B01_RS08145	COG4178	(ABC) transporter
N6B01_RS08165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N6B01_RS08175	COG4208	sulfate ABC transporter
N6B01_RS08180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N6B01_RS08190	COG2252	PERMEase
N6B01_RS08205	COG1073	alpha beta
N6B01_RS08210	COG0583	DNA-binding transcription factor activity
N6B01_RS08235	COG0625	glutathione transferase activity
N6B01_RS08250	COG4783	chaperone-mediated protein folding
N6B01_RS08265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N6B01_RS08285	COG0384	phenazine biosynthesis protein PhzF
N6B01_RS08295	COG1230	cation diffusion facilitator family transporter
N6B01_RS08310	COG0242	peptide deformylase activity
N6B01_RS08320	COG0101	tRNA pseudouridine synthase activity
N6B01_RS08330	COG2391	methyltransferase activity
N6B01_RS08360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N6B01_RS08365	COG1704	LemA family
N6B01_RS08385	COG1178	ABC-type Fe3 transport system permease component
N6B01_RS08415	COG0489	protein tyrosine kinase activity
N6B01_RS08435	COG2423	ornithine cyclodeaminase activity
N6B01_RS08450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N6B01_RS08455	COG0765	amino acid transport
N6B01_RS08460	COG0765	amino acid transport
N6B01_RS08470	COG4187	Peptidase family M20/M25/M40
N6B01_RS08475	COG1643	Atp-dependent helicase
N6B01_RS08505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N6B01_RS08505	COG0574	Belongs to the PEP-utilizing enzyme family
N6B01_RS08520	COG0583	DNA-binding transcription factor activity
N6B01_RS08535	COG3448	diguanylate cyclase activity
N6B01_RS08535	COG4175	Glycine betaine
N6B01_RS08550	COG0560	Phosphoserine phosphatase
N6B01_RS08555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N6B01_RS08565	COG0028	Belongs to the TPP enzyme family
N6B01_RS08570	COG0440	acetolactate synthase activity
N6B01_RS08580	COG2382	esterase
N6B01_RS08585	COG4774	siderophore transport
N6B01_RS08645	COG0789	Transcriptional regulator
N6B01_RS08650	COG0028	Belongs to the TPP enzyme family
N6B01_RS08660	COG1999	signal sequence binding
N6B01_RS08670	COG0006	proline dipeptidase activity
N6B01_RS08675	COG0009	L-threonylcarbamoyladenylate synthase
N6B01_RS08680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N6B01_RS08705	COG1376	ErfK ybiS ycfS ynhG family protein
N6B01_RS08710	COG1181	Belongs to the D-alanine--D-alanine ligase family
N6B01_RS08720	COG0849	cell division
N6B01_RS08735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N6B01_RS08735	COG1648	precorrin-2 dehydrogenase activity
N6B01_RS08745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N6B01_RS08755	COG3153	acetyltransferase
N6B01_RS08785	COG0753	catalase activity
N6B01_RS08795	COG1570	exodeoxyribonuclease VII activity
N6B01_RS08800	COG0519	Catalyzes the synthesis of GMP from XMP
N6B01_RS08805	COG0004	ammonium transporteR
N6B01_RS08810	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
N6B01_RS08820	COG1522	sequence-specific DNA binding
N6B01_RS08840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N6B01_RS08850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N6B01_RS08850	COG0195	Participates in both transcription termination and antitermination
N6B01_RS08855	COG0779	Required for maturation of 30S ribosomal subunits
N6B01_RS08870	COG0330	HflC and HflK could
N6B01_RS08875	COG0330	HflC and HflK could
N6B01_RS08880	COG0210	DNA helicase
N6B01_RS08890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N6B01_RS08895	COG0277	FAD linked oxidase domain protein
N6B01_RS08910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N6B01_RS08915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N6B01_RS08920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N6B01_RS08930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N6B01_RS08935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N6B01_RS08945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N6B01_RS08960	COG0275	rRNA processing
N6B01_RS08980	COG3209	COG3209 Rhs family protein
N6B01_RS08980	COG4104	PAAR repeat-containing protein
N6B01_RS09015	COG3209	COG3209 Rhs family protein
N6B01_RS09055	COG3501	Rhs element vgr protein
N6B01_RS09065	COG2814	Major facilitator Superfamily
N6B01_RS09070	COG2824	Alkylphosphonate utilization operon protein PhnA
N6B01_RS09085	COG1785	Belongs to the alkaline phosphatase family
N6B01_RS09145	COG1846	Transcriptional regulator
N6B01_RS09165	COG0505	Belongs to the CarA family
N6B01_RS09170	COG1304	FMN binding
N6B01_RS09175	COG0789	Transcriptional regulator
N6B01_RS09180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N6B01_RS09190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N6B01_RS09195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N6B01_RS09200	COG0747	negative chemotaxis
N6B01_RS09205	COG0747	negative chemotaxis
N6B01_RS09215	COG1388	LysM domain
N6B01_RS09215	COG1376	ErfK ybiS ycfS ynhG family protein
N6B01_RS09230	COG0351	phosphomethylpyrimidine kinase
N6B01_RS09240	COG2022	thiamine diphosphate biosynthetic process
N6B01_RS09260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N6B01_RS09285	COG2171	N-acyltransferase activity
N6B01_RS09295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N6B01_RS09295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N6B01_RS09300	COG1105	Belongs to the carbohydrate kinase PfkB family
N6B01_RS09305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N6B01_RS09305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N6B01_RS09310	COG1609	Transcriptional regulator
N6B01_RS09325	COG2807	transmembrane transport
N6B01_RS09330	COG0400	carboxylic ester hydrolase activity
N6B01_RS09345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N6B01_RS09350	COG0594	ribonuclease P activity
N6B01_RS09360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N6B01_RS09375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N6B01_RS09385	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N6B01_RS09400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N6B01_RS09400	COG2857	Cytochrome c1
N6B01_RS09405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N6B01_RS09415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N6B01_RS09420	COG0012	GTP binding
N6B01_RS09425	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N6B01_RS09440	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
N6B01_RS09450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N6B01_RS09455	COG1268	BioY protein
N6B01_RS09460	COG3338	carbonate dehydratase activity
N6B01_RS09475	COG4106	trans-aconitate 2-methyltransferase activity
N6B01_RS09480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
N6B01_RS09490	COG1278	Cold shock
N6B01_RS09500	COG3655	Transcriptional regulator
N6B01_RS09515	COG1120	ATPase activity
N6B01_RS09520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N6B01_RS09525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N6B01_RS09540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N6B01_RS09545	COG0358	DNA primase activity
N6B01_RS09555	COG0668	transmembrane transport
N6B01_RS09560	COG0459	protein refolding
N6B01_RS09565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N6B01_RS09580	COG1609	Transcriptional regulator
N6B01_RS09620	COG0281	malic enzyme
N6B01_RS09620	COG0280	phosphate acetyltransferase
N6B01_RS09660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N6B01_RS09670	COG0583	DNA-binding transcription factor activity
N6B01_RS09685	COG0477	Major facilitator Superfamily
N6B01_RS09690	COG0534	Mate efflux family protein
N6B01_RS09695	COG0129	dihydroxy-acid dehydratase activity
N6B01_RS09700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N6B01_RS09705	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N6B01_RS09710	COG4208	sulfate ABC transporter
N6B01_RS09715	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N6B01_RS09720	COG4150	thiosulfate binding
N6B01_RS09730	COG4215	(ABC) transporter
N6B01_RS09740	COG1126	abc transporter atp-binding protein
N6B01_RS09745	COG0284	orotidine-5'-phosphate decarboxylase activity
N6B01_RS09750	COG0427	acetyl-CoA hydrolase
N6B01_RS09765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N6B01_RS09775	COG0825	malonyl-CoA metabolic process
N6B01_RS09790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N6B01_RS09805	COG1473	amidohydrolase
N6B01_RS09825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N6B01_RS09830	COG0509	glycine decarboxylation via glycine cleavage system
N6B01_RS09835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N6B01_RS09835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N6B01_RS09860	COG4772	TonB-dependent receptor
N6B01_RS09875	COG0531	amino acid
N6B01_RS09890	COG0747	negative chemotaxis
N6B01_RS09895	COG0747	negative chemotaxis
N6B01_RS09905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N6B01_RS09910	COG1473	amidohydrolase
N6B01_RS09920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6B01_RS09925	COG0601	transmembrane transport
N6B01_RS09940	COG0673	inositol 2-dehydrogenase activity
N6B01_RS09965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N6B01_RS10005	COG1335	isochorismatase
N6B01_RS10010	COG4977	sequence-specific DNA binding
N6B01_RS10030	COG0656	L-ascorbic acid biosynthetic process
N6B01_RS10070	COG0137	argininosuccinate synthase activity
N6B01_RS10075	COG4589	Belongs to the CDS family
N6B01_RS10085	COG0671	phosphoesterase, PA-phosphatase related
N6B01_RS10085	COG2453	phosphatase
N6B01_RS10090	COG2267	carboxylic ester hydrolase activity
N6B01_RS10095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N6B01_RS10105	COG0477	Major facilitator Superfamily
N6B01_RS10120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N6B01_RS10125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N6B01_RS10145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N6B01_RS10155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N6B01_RS10165	COG0156	8-amino-7-oxononanoate synthase activity
N6B01_RS10200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N6B01_RS10205	COG0483	inositol monophosphate 1-phosphatase activity
N6B01_RS10235	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
N6B01_RS10235	COG0662	Cupin 2, conserved barrel domain protein
N6B01_RS10240	COG2233	PERMEase
N6B01_RS10250	COG0494	nUDIX hydrolase
N6B01_RS10255	COG0456	acetyltransferase
N6B01_RS10255	COG0454	-acetyltransferase
N6B01_RS10260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N6B01_RS10275	COG2864	formate dehydrogenase
N6B01_RS10280	COG0437	4 iron, 4 sulfur cluster binding
N6B01_RS10305	COG1388	LysM domain
N6B01_RS10305	COG1376	ErfK ybiS ycfS ynhG family protein
N6B01_RS10315	COG4771	TonB-dependent receptor
N6B01_RS10320	COG0656	L-ascorbic acid biosynthetic process
N6B01_RS10350	COG2353	YceI-like domain
N6B01_RS10355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N6B01_RS10375	COG1902	pentaerythritol trinitrate reductase activity
N6B01_RS10380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N6B01_RS10380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N6B01_RS10420	COG1335	isochorismatase
N6B01_RS10465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N6B01_RS10475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N6B01_RS10480	COG0799	negative regulation of ribosome biogenesis
N6B01_RS10490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N6B01_RS10495	COG0167	dihydroorotate dehydrogenase activity
N6B01_RS10515	COG0848	biopolymer transport protein
N6B01_RS10525	COG3842	ATPase activity
N6B01_RS10540	COG0395	ABC-type sugar transport system, permease component
N6B01_RS10565	COG1126	abc transporter atp-binding protein
N6B01_RS10595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N6B01_RS10605	COG2346	COG2346, Truncated hemoglobins
N6B01_RS10615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N6B01_RS10630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N6B01_RS10635	COG0567	Dehydrogenase, E1 component
N6B01_RS10640	COG0508	dehydrogenase complex catalyzes the overall conversion of
N6B01_RS10670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N6B01_RS10680	COG0392	lysyltransferase activity
N6B01_RS10680	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N6B01_RS10710	COG2010	Cytochrome c
N6B01_RS10715	COG4778	phosphonate C-P lyase system protein PhnL
N6B01_RS10720	COG4107	phosphonate C-P lyase system protein PhnK
N6B01_RS10725	COG3627	carbon phosphorus lyase activity
N6B01_RS10745	COG2188	Transcriptional regulator
N6B01_RS10750	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N6B01_RS10755	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
N6B01_RS10760	COG3639	organic phosphonate transmembrane transporter activity
N6B01_RS10765	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
N6B01_RS10770	COG3454	Phosphonate metabolism
N6B01_RS10790	COG0745	RESPONSE REGULATOR receiver
N6B01_RS10800	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
N6B01_RS10830	COG3209	COG3209 Rhs family protein
N6B01_RS10845	COG3501	Rhs element vgr protein
N6B01_RS10875	COG3501	Rhs element vgr protein
N6B01_RS10885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N6B01_RS10910	COG1823	symporter activity
N6B01_RS10915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N6B01_RS10930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N6B01_RS10950	COG0730	response to heat
N6B01_RS10970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N6B01_RS10975	COG1902	pentaerythritol trinitrate reductase activity
N6B01_RS10980	COG0697	spore germination
N6B01_RS10985	COG0583	DNA-binding transcription factor activity
N6B01_RS10990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N6B01_RS11000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N6B01_RS11010	COG0142	geranyltranstransferase activity
N6B01_RS11040	COG0842	Transport permease protein
N6B01_RS11045	COG0842	Transport permease protein
N6B01_RS11045	COG1129	ABC transporter
N6B01_RS11050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N6B01_RS11055	COG2205	protein histidine kinase activity
N6B01_RS11060	COG0745	RESPONSE REGULATOR receiver
N6B01_RS11065	COG1846	Transcriptional regulator
N6B01_RS11070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N6B01_RS11075	COG0783	Belongs to the Dps family
N6B01_RS11080	COG0217	transcriptional regulatory protein
N6B01_RS11085	COG1268	BioY protein
N6B01_RS11115	COG2205	protein histidine kinase activity
N6B01_RS11135	COG2755	lipolytic protein G-D-S-L family
N6B01_RS11135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N6B01_RS11140	COG0601	transmembrane transport
N6B01_RS11145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6B01_RS11150	COG0444	Belongs to the ABC transporter superfamily
N6B01_RS11155	COG4608	Belongs to the ABC transporter superfamily
N6B01_RS11160	COG1739	Uncharacterized protein family UPF0029
N6B01_RS11195	COG0287	Prephenate dehydrogenase
N6B01_RS11205	COG0729	surface antigen
N6B01_RS11215	COG0484	heat shock protein binding
N6B01_RS11245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N6B01_RS11255	COG1496	oxidoreductase activity
N6B01_RS11270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N6B01_RS11275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N6B01_RS11285	COG5328	Belongs to the UPF0262 family
N6B01_RS11305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N6B01_RS11310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N6B01_RS11315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N6B01_RS11335	COG1185	polyribonucleotide nucleotidyltransferase activity
N6B01_RS11340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N6B01_RS11350	COG0659	secondary active sulfate transmembrane transporter activity
N6B01_RS11355	COG0589	response to stress
N6B01_RS11360	COG0473	3-isopropylmalate dehydrogenase activity
N6B01_RS11370	COG0492	ferredoxin-NADP+ reductase activity
N6B01_RS11375	COG0583	DNA-binding transcription factor activity
N6B01_RS11410	COG0793	Belongs to the peptidase S41A family
N6B01_RS11420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N6B01_RS11425	COG1946	Acyl-CoA thioesterase
N6B01_RS11460	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N6B01_RS11465	COG2835	tetraacyldisaccharide 4'-kinase activity
N6B01_RS11470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N6B01_RS11475	COG3135	benzoate transporter
N6B01_RS11485	COG0612	Peptidase, M16
N6B01_RS11490	COG0612	Peptidase, M16
N6B01_RS11495	COG0742	ribosomal rna small subunit methyltransferase
N6B01_RS11515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N6B01_RS11540	COG1473	amidohydrolase
N6B01_RS11550	COG0717	Belongs to the dCTP deaminase family
N6B01_RS11590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N6B01_RS11595	COG0174	glutamine synthetase
N6B01_RS11640	COG0500	methyltransferase
N6B01_RS11650	COG1921	L-seryl-tRNASec selenium transferase activity
N6B01_RS11665	COG1201	RNA secondary structure unwinding
N6B01_RS11780	COG1783	phage Terminase large subunit
N6B01_RS11805	COG0667	Aldo Keto reductase
N6B01_RS11810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N6B01_RS11840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N6B01_RS11845	COG1120	ATPase activity
N6B01_RS11885	COG1335	isochorismatase
N6B01_RS11890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N6B01_RS11895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N6B01_RS11900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N6B01_RS11905	COG3920	Histidine kinase
N6B01_RS11905	COG2202	Pas domain
N6B01_RS11910	COG0271	Belongs to the BolA IbaG family
N6B01_RS11920	COG0483	inositol monophosphate 1-phosphatase activity
N6B01_RS11940	COG2226	methyltransferase
N6B01_RS11955	COG1609	Transcriptional regulator
N6B01_RS11960	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
N6B01_RS11965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6B01_RS11970	COG1172	Belongs to the binding-protein-dependent transport system permease family
N6B01_RS11980	COG4213	ABC transporter substrate-binding protein
N6B01_RS12020	COG0745	RESPONSE REGULATOR receiver
N6B01_RS12025	COG0704	Plays a role in the regulation of phosphate uptake
N6B01_RS12030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N6B01_RS12040	COG0573	inorganic phosphate transmembrane transporter activity
N6B01_RS12050	COG0189	ligase activity
N6B01_RS12055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N6B01_RS12060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6B01_RS12080	COG1028	Short-chain dehydrogenase reductase Sdr
N6B01_RS12090	COG0501	Belongs to the peptidase M48B family
N6B01_RS12095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N6B01_RS12095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N6B01_RS12105	COG2309	aminopeptidase activity
N6B01_RS12110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N6B01_RS12115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N6B01_RS12130	COG4172	Belongs to the ABC transporter superfamily
N6B01_RS12135	COG4239	(ABC) transporter, permease
N6B01_RS12140	COG4174	ABC transporter (Permease)
N6B01_RS12145	COG4166	transmembrane transport
N6B01_RS12150	COG3474	cytochrome
N6B01_RS12170	COG2340	Cysteine-rich secretory protein family
N6B01_RS12180	COG2169	Transcriptional regulator
N6B01_RS12180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N6B01_RS12185	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N6B01_RS12190	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N6B01_RS12200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N6B01_RS12230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N6B01_RS12235	COG4133	protoheme IX ABC transporter activity
N6B01_RS12240	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N6B01_RS12245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N6B01_RS12255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N6B01_RS12265	COG0644	oxidoreductase
N6B01_RS12305	COG3052	prosthetic group binding
N6B01_RS12325	COG1802	Transcriptional regulator
N6B01_RS12335	COG3552	Protein containing von Willebrand factor type A (VWA) domain
N6B01_RS12345	COG0714	Associated with various cellular activities
N6B01_RS12350	COG3831	ATPase activity
N6B01_RS12355	COG3831	ATPase activity
N6B01_RS12360	COG3831	ATPase activity
N6B01_RS12380	COG5290	Psort location Cytoplasmic, score
N6B01_RS12435	COG3048	D-serine ammonia-lyase activity
N6B01_RS12445	COG0564	pseudouridine synthase activity
N6B01_RS12455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N6B01_RS12460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N6B01_RS12545	COG1082	Xylose isomerase domain protein TIM barrel
N6B01_RS12545	COG3185	4-Hydroxyphenylpyruvate dioxygenase
N6B01_RS12550	COG0183	Belongs to the thiolase family
N6B01_RS12555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N6B01_RS12565	COG0477	Major facilitator Superfamily
N6B01_RS12595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N6B01_RS12600	COG1217	gtp-binding protein TYPA
N6B01_RS12605	COG0709	Synthesizes selenophosphate from selenide and ATP
N6B01_RS12610	COG1692	metallophosphoesterase
N6B01_RS12635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N6B01_RS12640	COG0495	leucyl-tRNA aminoacylation
N6B01_RS12655	COG0457	Tetratricopeptide repeat
N6B01_RS12665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N6B01_RS12680	COG0490	domain, Protein
N6B01_RS12680	COG0471	metal ion transport
N6B01_RS12725	COG0357	Ribosomal RNA small subunit methyltransferase G
N6B01_RS12730	COG0445	tRNA wobble uridine modification
N6B01_RS12735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N6B01_RS12740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N6B01_RS12745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N6B01_RS12745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N6B01_RS12750	COG1981	membrane
N6B01_RS12760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N6B01_RS12765	COG0523	cobalamin synthesis protein
N6B01_RS12775	COG0747	negative chemotaxis
N6B01_RS12780	COG0601	transmembrane transport
N6B01_RS12785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6B01_RS12790	COG4172	Belongs to the ABC transporter superfamily
N6B01_RS12795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N6B01_RS12820	COG0312	modulator of DNA gyrase
N6B01_RS12825	COG2217	Heavy metal translocating P-type atpase
N6B01_RS12850	COG1741	Belongs to the pirin family
N6B01_RS12870	COG3128	pkhd-type hydroxylase
N6B01_RS12875	COG4774	siderophore transport
N6B01_RS12880	COG2900	Belongs to the SlyX family
N6B01_RS12910	COG0539	negative regulation of cytoplasmic translation
N6B01_RS12925	COG2832	Protein of unknown function (DUF454)
N6B01_RS12930	COG3237	CsbD-like
N6B01_RS12945	COG1028	Short-chain dehydrogenase reductase Sdr
N6B01_RS12950	COG0778	Nitroreductase
N6B01_RS12960	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
N6B01_RS12970	COG1522	sequence-specific DNA binding
N6B01_RS12980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N6B01_RS12985	COG4558	Periplasmic binding protein
N6B01_RS13005	COG1177	transmembrane transport
N6B01_RS13010	COG1176	ABC-type spermidine putrescine transport system, permease component I
N6B01_RS13015	COG3842	ATPase activity
N6B01_RS13035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N6B01_RS13040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N6B01_RS13045	COG0653	protein targeting
N6B01_RS13055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N6B01_RS13070	COG1028	Short-chain dehydrogenase reductase Sdr
N6B01_RS13075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N6B01_RS13080	COG0363	glucosamine-6-phosphate deaminase activity
N6B01_RS13085	COG3459	Glycosyltransferase 36 associated
N6B01_RS13090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N6B01_RS13095	COG0237	dephospho-CoA kinase activity
N6B01_RS13100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N6B01_RS13105	COG0424	maF-like protein
N6B01_RS13140	COG0010	Belongs to the arginase family
N6B01_RS13145	COG2070	2-Nitropropane dioxygenase
N6B01_RS13170	COG0714	Associated with various cellular activities
N6B01_RS13175	COG2425	protein containing a von Willebrand factor type A (vWA) domain
N6B01_RS13180	COG3552	Protein containing von Willebrand factor type A (VWA) domain
N6B01_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
N6B01_RS13200	COG1028	Short-chain dehydrogenase reductase Sdr
N6B01_RS13225	COG0697	spore germination
N6B01_RS13230	COG0019	diaminopimelate decarboxylase activity
N6B01_RS13255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N6B01_RS13260	COG0071	Belongs to the small heat shock protein (HSP20) family
N6B01_RS13270	COG2862	Uncharacterized protein family, UPF0114
N6B01_RS13295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N6B01_RS13300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N6B01_RS13305	COG0552	protein localization to endoplasmic reticulum
N6B01_RS13350	COG4191	Histidine kinase
N6B01_RS13355	COG4566	intracellular signal transduction
N6B01_RS13360	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N6B01_RS13430	COG0671	phosphoesterase, PA-phosphatase related
N6B01_RS13435	COG1132	(ABC) transporter
N6B01_RS13450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N6B01_RS13460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N6B01_RS13465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N6B01_RS13470	COG0739	heme binding
N6B01_RS13540	COG1028	Short-chain dehydrogenase reductase Sdr
N6B01_RS13545	COG1309	transcriptional regulator
N6B01_RS13555	COG1122	ATPase activity
N6B01_RS13575	COG0488	(ABC) transporter
N6B01_RS13580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N6B01_RS13615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N6B01_RS13635	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N6B01_RS13640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N6B01_RS13645	COG0183	Belongs to the thiolase family
N6B01_RS13650	COG2188	Transcriptional regulator
N6B01_RS13655	COG0579	oxidoreductase
N6B01_RS13680	COG0583	DNA-binding transcription factor activity
N6B01_RS13685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N6B01_RS13690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N6B01_RS13695	COG3485	protocatechuate 3,4-dioxygenase
N6B01_RS13700	COG3485	protocatechuate 3,4-dioxygenase
N6B01_RS13705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N6B01_RS13715	COG0673	inositol 2-dehydrogenase activity
N6B01_RS13720	COG1053	succinate dehydrogenase
N6B01_RS13725	COG1053	succinate dehydrogenase
N6B01_RS13760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N6B01_RS13765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N6B01_RS13775	COG1192	Involved in chromosome partitioning
N6B01_RS13780	COG1475	DNA binding
N6B01_RS13805	COG2076	Multidrug Resistance protein
N6B01_RS13820	COG0745	RESPONSE REGULATOR receiver
N6B01_RS13825	COG5002	protein histidine kinase activity
N6B01_RS13825	COG3850	Histidine kinase
N6B01_RS13845	COG1088	dTDP-glucose 4,6-dehydratase activity
N6B01_RS13850	COG1091	dTDP-4-dehydrorhamnose reductase activity
N6B01_RS13860	COG2720	vancomycin resistance protein
N6B01_RS13945	COG3609	addiction module antidote protein, CC2985 family
N6B01_RS13950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N6B01_RS13955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N6B01_RS13965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N6B01_RS13970	COG0814	amino acid
N6B01_RS13975	COG1448	Aminotransferase
N6B01_RS13990	COG1113	amino acid transport
N6B01_RS13995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N6B01_RS14015	COG1696	Membrane protein involved in D-alanine export
N6B01_RS14035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N6B01_RS14045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N6B01_RS14100	COG2188	Transcriptional regulator
N6B01_RS14115	COG4120	Belongs to the binding-protein-dependent transport system permease family
N6B01_RS14120	COG1122	ATPase activity
N6B01_RS14125	COG2814	Major facilitator Superfamily
N6B01_RS14140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N6B01_RS14150	COG2986	histidine ammonia-lyase
N6B01_RS14155	COG1228	amidohydrolase
N6B01_RS14170	COG1288	antiporter activity
N6B01_RS14175	COG1288	antiporter activity
N6B01_RS14190	COG1268	BioY protein
N6B01_RS14200	COG1116	anion transmembrane transporter activity
N6B01_RS14205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N6B01_RS14210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N6B01_RS14260	COG2373	Large extracellular alpha-helical protein
N6B01_RS14265	COG4953	penicillin-binding protein 1C
N6B01_RS14310	COG2315	Protein conserved in bacteria
N6B01_RS14335	COG2814	Major facilitator Superfamily
N6B01_RS14345	COG1522	sequence-specific DNA binding
N6B01_RS14350	COG0371	Dehydrogenase
N6B01_RS14360	COG1028	Short-chain dehydrogenase reductase Sdr
N6B01_RS14380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N6B01_RS14385	COG2313	pseudouridylate synthase activity
N6B01_RS14390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N6B01_RS14435	COG1063	alcohol dehydrogenase
N6B01_RS14440	COG3800	Transcriptional regulator
N6B01_RS14440	COG1396	sequence-specific DNA binding
N6B01_RS14445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N6B01_RS14450	COG4770	biotin carboxylase activity
N6B01_RS14455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N6B01_RS14455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N6B01_RS14460	COG0346	lactoylglutathione lyase activity
N6B01_RS14495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N6B01_RS14510	COG0583	DNA-binding transcription factor activity
N6B01_RS14520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N6B01_RS14545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N6B01_RS14560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N6B01_RS14575	COG1475	DNA binding
N6B01_RS14580	COG1192	Involved in chromosome partitioning
N6B01_RS14720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N6B01_RS14760	COG4771	TonB-dependent receptor
N6B01_RS14765	COG4771	TonB-dependent receptor
N6B01_RS14775	COG1132	(ABC) transporter
N6B01_RS14775	COG2375	cellular response to nickel ion
N6B01_RS14780	COG1132	(ABC) transporter
N6B01_RS14835	COG3829	transcription factor binding
N6B01_RS14860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N6B01_RS14860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N6B01_RS14865	COG3711	transcriptional antiterminator
N6B01_RS14880	COG3964	amidohydrolase
N6B01_RS14920	COG2161	toxin-antitoxin pair type II binding
N6B01_RS14925	COG4115	mRNA cleavage
N6B01_RS14950	COG3188	usher protein
N6B01_RS14980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N6B01_RS14990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N6B01_RS15045	COG3550	peptidyl-serine autophosphorylation
N6B01_RS15065	COG1204	response to ionizing radiation
N6B01_RS15110	COG3609	addiction module antidote protein, CC2985 family
N6B01_RS15130	COG1442	glycosyl transferase family 8