locus-tag	class	description
D1092_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1092_RS00020	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1092_RS00030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1092_RS00035	COG1845	cytochrome c oxidase, subunit III
D1092_RS00040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D1092_RS00045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1092_RS00050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1092_RS00060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1092_RS00075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1092_RS00080	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D1092_RS00095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1092_RS00100	COG0166	Belongs to the GPI family
D1092_RS00115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1092_RS00120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1092_RS00125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1092_RS00125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1092_RS00150	COG2814	Major facilitator Superfamily
D1092_RS00240	COG0248	Ppx GppA phosphatase
D1092_RS00245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1092_RS00250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1092_RS00255	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1092_RS00260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1092_RS00265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1092_RS00270	COG0799	negative regulation of ribosome biogenesis
D1092_RS00275	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1092_RS00285	COG0793	Belongs to the peptidase S41A family
D1092_RS00290	COG0494	nUDIX hydrolase
D1092_RS00295	COG5342	invasion associated locus B
D1092_RS00305	COG1872	DUF167
D1092_RS00310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1092_RS00315	COG1217	gtp-binding protein TYPA
D1092_RS00320	COG2239	Acts as a magnesium transporter
D1092_RS00325	COG0339	signal peptide processing
D1092_RS00335	COG2951	lytic endotransglycosylase activity
D1092_RS00340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1092_RS00345	COG0517	IMP dehydrogenase activity
D1092_RS00345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1092_RS00360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1092_RS00370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1092_RS00370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1092_RS00375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1092_RS00375	COG0519	Catalyzes the synthesis of GMP from XMP
D1092_RS00380	COG0584	glycerophosphoryl diester phosphodiesterase
D1092_RS00390	COG1175	transmembrane transport
D1092_RS00395	COG0395	ABC-type sugar transport system, permease component
D1092_RS00400	COG3842	ATPase activity
D1092_RS00405	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1092_RS00425	COG1780	Probably involved in ribonucleotide reductase function
D1092_RS00430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1092_RS00440	COG2890	protein-(glutamine-N5) methyltransferase activity
D1092_RS00445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1092_RS00455	COG0653	protein targeting
D1092_RS00460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1092_RS00465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1092_RS00475	COG0791	NLP P60 protein
D1092_RS00480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1092_RS00485	COG1072	(Pantothenic acid kinase))
D1092_RS00490	COG0252	asparaginase activity
D1092_RS00495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D1092_RS00500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D1092_RS00505	COG2813	Specifically methylates the guanine in position
D1092_RS00510	COG1185	polyribonucleotide nucleotidyltransferase activity
D1092_RS00515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1092_RS00525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1092_RS00530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1092_RS00535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1092_RS00545	COG0195	Participates in both transcription termination and antitermination
D1092_RS00545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1092_RS00550	COG0779	Required for maturation of 30S ribosomal subunits
D1092_RS00555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1092_RS00560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1092_RS00565	COG1396	sequence-specific DNA binding
D1092_RS00575	COG4535	Mg2 and Co2 transporter CorC
D1092_RS00580	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1092_RS00585	COG1702	phosphate starvation-inducible protein PhoH
D1092_RS00590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1092_RS00600	COG1214	PFAM Peptidase M22, glycoprotease
D1092_RS00605	COG2855	membrane
D1092_RS00610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1092_RS00615	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1092_RS00635	COG1605	Chorismate mutase
D1092_RS00635	COG0077	Prephenate dehydratase
D1092_RS00640	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D1092_RS00645	COG3474	cytochrome
D1092_RS00655	COG0189	ligase activity
D1092_RS00665	COG0573	inorganic phosphate transmembrane transporter activity
D1092_RS00675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1092_RS00680	COG0704	Plays a role in the regulation of phosphate uptake
D1092_RS00695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1092_RS00705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1092_RS00715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1092_RS00720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1092_RS00740	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1092_RS00745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1092_RS00760	COG0590	tRNA wobble adenosine to inosine editing
D1092_RS00765	COG1187	pseudouridine synthase activity
D1092_RS00770	COG0742	ribosomal rna small subunit methyltransferase
D1092_RS00780	COG0312	modulator of DNA gyrase
D1092_RS00785	COG0483	inositol monophosphate 1-phosphatase activity
D1092_RS00795	COG1519	Transferase
D1092_RS00800	COG1663	tetraacyldisaccharide 4'-kinase activity
D1092_RS00810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D1092_RS00815	COG0717	Belongs to the dCTP deaminase family
D1092_RS00820	COG1304	FMN binding
D1092_RS00860	COG1113	amino acid transport
D1092_RS00865	COG1122	ATPase activity
D1092_RS00875	COG1268	BioY protein
D1092_RS00880	COG1268	BioY protein
D1092_RS00900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1092_RS00910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1092_RS00915	COG0564	pseudouridine synthase activity
D1092_RS00935	COG1970	mechanosensitive ion channel activity
D1092_RS00940	COG0167	dihydroorotate dehydrogenase activity
D1092_RS01005	COG0534	Mate efflux family protein
D1092_RS01050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1092_RS01060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1092_RS01065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1092_RS01070	COG0363	glucosamine-6-phosphate deaminase activity
D1092_RS01075	COG0129	dihydroxy-acid dehydratase activity
D1092_RS01080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1092_RS01105	COG1823	symporter activity
D1092_RS01115	COG1040	competence protein
D1092_RS01120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1092_RS01125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1092_RS01130	COG0527	aspartate kinase activity
D1092_RS01135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1092_RS01140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1092_RS01150	COG0471	metal ion transport
D1092_RS01150	COG3273	potassium ion transport
D1092_RS01160	COG1160	GTP binding
D1092_RS01170	COG0356	it plays a direct role in the translocation of protons across the membrane
D1092_RS01175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1092_RS01180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1092_RS01185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1092_RS01200	COG2070	2-Nitropropane dioxygenase
D1092_RS01240	COG0751	glycine-tRNA ligase activity
D1092_RS01255	COG0142	geranyltranstransferase activity
D1092_RS01270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1092_RS01275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1092_RS01280	COG0009	L-threonylcarbamoyladenylate synthase
D1092_RS01285	COG0277	FAD linked oxidase domain protein
D1092_RS01300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1092_RS01305	COG0259	pyridoxamine-phosphate oxidase activity
D1092_RS01310	COG0484	heat shock protein binding
D1092_RS01315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1092_RS01320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1092_RS01325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1092_RS01325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1092_RS01330	COG1722	exodeoxyribonuclease VII activity
D1092_RS01335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1092_RS01340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D1092_RS01350	COG0312	modulator of DNA gyrase
D1092_RS01360	COG0109	protoheme IX farnesyltransferase activity
D1092_RS01365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1092_RS01370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D1092_RS01375	COG0328	RNA-DNA hybrid ribonuclease activity
D1092_RS01385	COG1678	Uncharacterized ACR, COG1678
D1092_RS01390	COG5001	Diguanylate cyclase
D1092_RS01390	COG1716	ATPase activity
D1092_RS01395	COG0612	Peptidase, M16
D1092_RS01430	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D1092_RS01435	COG1194	a g-specific adenine glycosylase
D1092_RS01445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1092_RS01450	COG0574	Belongs to the PEP-utilizing enzyme family
D1092_RS01450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1092_RS01475	COG2166	iron-sulfur cluster assembly
D1092_RS01490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1092_RS01565	COG3093	addiction module antidote protein HigA
D1092_RS01575	COG0629	single-stranded DNA binding
D1092_RS01625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1092_RS01650	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D1092_RS01655	COG1138	Cytochrome C-type biogenesis protein
D1092_RS01660	COG3088	subunit of a heme lyase
D1092_RS01665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1092_RS01670	COG0745	RESPONSE REGULATOR receiver
D1092_RS01675	COG0642	Histidine kinase
D1092_RS01680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D1092_RS01685	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1092_RS01710	COG0714	Associated with various cellular activities
D1092_RS01715	COG0617	tRNA 3'-terminal CCA addition
D1092_RS01720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1092_RS01725	COG0723	plastoquinol--plastocyanin reductase activity
D1092_RS01735	COG2857	Cytochrome c1
D1092_RS01735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1092_RS01745	COG0012	GTP binding
D1092_RS01750	COG1376	ErfK ybiS ycfS ynhG family protein
D1092_RS01755	COG0193	aminoacyl-tRNA hydrolase activity
D1092_RS01760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1092_RS01775	COG1496	oxidoreductase activity
D1092_RS01785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1092_RS01800	COG2205	protein histidine kinase activity
D1092_RS01805	COG0745	RESPONSE REGULATOR receiver
D1092_RS01810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1092_RS01820	COG0556	nucleotide-excision repair
D1092_RS01830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1092_RS01840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1092_RS01845	COG0492	ferredoxin-NADP+ reductase activity
D1092_RS01850	COG0583	DNA-binding transcription factor activity
D1092_RS01855	COG0436	Aminotransferase
D1092_RS01860	COG1278	Cold shock
D1092_RS01875	COG2205	protein histidine kinase activity
D1092_RS01875	COG2202	Pas domain
D1092_RS01880	COG0308	aminopeptidase N
D1092_RS01900	COG2022	thiamine diphosphate biosynthetic process
D1092_RS01915	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1092_RS01925	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D1092_RS01930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1092_RS01935	COG4558	Periplasmic binding protein
D1092_RS01940	COG3720	iron ion transport
D1092_RS01945	COG4771	TonB-dependent receptor
D1092_RS01960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1092_RS01965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1092_RS01970	COG1573	uracil-dna glycosylase
D1092_RS01975	COG1758	RNA polymerase activity
D1092_RS01980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1092_RS01985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1092_RS01995	COG0736	holo-[acyl-carrier-protein] synthase activity
D1092_RS02000	COG0681	Belongs to the peptidase S26 family
D1092_RS02005	COG0571	ribonuclease III activity
D1092_RS02015	COG1381	Involved in DNA repair and RecF pathway recombination
D1092_RS02020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1092_RS02025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1092_RS02030	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D1092_RS02035	COG0354	folic acid binding
D1092_RS02040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1092_RS02050	COG0215	cysteine-tRNA ligase activity
D1092_RS02060	COG5265	(ABC) transporter
D1092_RS02065	COG0688	phosphatidylethanolamine metabolic process
D1092_RS02070	COG1183	phosphatidylcholine synthase activity
D1092_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
D1092_RS02080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1092_RS02100	COG0359	binds to the 23S rRNA
D1092_RS02110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1092_RS02115	COG0360	Binds together with S18 to 16S ribosomal RNA
D1092_RS02125	COG0671	phosphoesterase, PA-phosphatase related
D1092_RS02130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1092_RS02140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1092_RS02145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1092_RS02150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1092_RS02155	COG0194	GDP metabolic process
D1092_RS02160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1092_RS02165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D1092_RS02205	COG0477	Major facilitator Superfamily
D1092_RS02225	COG0105	UTP biosynthetic process
D1092_RS02230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1092_RS02235	COG0322	excinuclease ABC activity
D1092_RS02240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1092_RS02245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1092_RS02250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1092_RS02255	COG0805	protein transport
D1092_RS02260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1092_RS02265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1092_RS02270	COG4942	peptidase
D1092_RS02275	COG1862	Preprotein translocase
D1092_RS02295	COG0149	triose-phosphate isomerase activity
D1092_RS02300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1092_RS02305	COG0504	CTP synthase activity
D1092_RS02310	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D1092_RS02315	COG0148	phosphopyruvate hydratase activity
D1092_RS02330	COG2314	TM2 domain
D1092_RS02340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1092_RS02345	COG0022	dehydrogenase e1 component
D1092_RS02345	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1092_RS02350	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1092_RS02355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1092_RS02360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1092_RS02365	COG2867	negative regulation of translational initiation
D1092_RS02370	COG1546	Belongs to the CinA family
D1092_RS02370	COG1058	Belongs to the CinA family
D1092_RS02375	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1092_RS02380	COG1959	2 iron, 2 sulfur cluster binding
D1092_RS02385	COG5000	phosphorelay sensor kinase activity
D1092_RS02390	COG2204	response regulator
D1092_RS02395	COG0569	domain protein
D1092_RS02405	COG0740	serine-type endopeptidase activity
D1092_RS02410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1092_RS02425	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D1092_RS02435	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1092_RS02440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1092_RS02450	COG4765	Protein conserved in bacteria
D1092_RS02460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1092_RS02475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1092_RS02485	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1092_RS02495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1092_RS02500	COG0081	regulation of translation
D1092_RS02505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1092_RS02510	COG0222	ribosome binding
D1092_RS02515	COG0085	RNA polymerase activity
D1092_RS02520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1092_RS02635	COG3646	Phage regulatory protein
D1092_RS02640	COG0629	single-stranded DNA binding
D1092_RS02645	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1092_RS02670	COG2831	hemolysin activation secretion protein
D1092_RS02675	COG3210	domain, Protein
D1092_RS02675	COG3210	domain, Protein
D1092_RS02730	COG0582	viral genome integration into host DNA
D1092_RS02790	COG0697	spore germination
D1092_RS02830	COG0582	viral genome integration into host DNA
D1092_RS02870	COG1760	l-serine dehydratase
D1092_RS02880	COG1686	Belongs to the peptidase S11 family
D1092_RS02885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D1092_RS02910	COG0052	Belongs to the universal ribosomal protein uS2 family
D1092_RS02915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1092_RS02920	COG0528	UMP kinase activity
D1092_RS02925	COG0233	cytoplasmic translational termination
D1092_RS02935	COG0750	zinc metalloprotease
D1092_RS02940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1092_RS02945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1092_RS02950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1092_RS02955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1092_RS02960	COG3494	Protein of unknown function (DUF1009)
D1092_RS02965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1092_RS02970	COG1126	abc transporter atp-binding protein
D1092_RS02990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1092_RS02995	COG0372	Belongs to the citrate synthase family
D1092_RS03000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1092_RS03005	COG0658	competence protein
D1092_RS03005	COG2333	competence protein COMEC
D1092_RS03010	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1092_RS03025	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1092_RS03035	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D1092_RS03035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1092_RS03075	COG2831	hemolysin activation secretion protein
D1092_RS03080	COG3210	domain, Protein
D1092_RS03080	COG3210	domain, Protein
D1092_RS03090	COG3210	domain, Protein
D1092_RS03115	COG3210	domain, Protein
D1092_RS03150	COG3210	domain, Protein
D1092_RS03185	COG3210	domain, Protein
D1092_RS03210	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D1092_RS03235	COG0174	glutamine synthetase
D1092_RS03240	COG0347	Belongs to the P(II) protein family
D1092_RS03255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1092_RS03260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1092_RS03275	COG0343	queuine tRNA-ribosyltransferase activity
D1092_RS03280	COG2814	Major facilitator Superfamily
D1092_RS03290	COG0538	isocitrate dehydrogenase activity
D1092_RS03310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1092_RS03325	COG0018	arginyl-trna synthetase
D1092_RS03330	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1092_RS03335	COG0316	Belongs to the HesB IscA family
D1092_RS03345	COG0785	Cytochrome C biogenesis protein
D1092_RS03350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1092_RS03355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1092_RS03360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1092_RS03370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1092_RS03380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1092_RS03385	COG0248	Ppx GppA phosphatase
D1092_RS03390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1092_RS03395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1092_RS03400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1092_RS03405	COG2814	Major facilitator Superfamily
D1092_RS03410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1092_RS03420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1092_RS03425	COG0047	phosphoribosylformylglycinamidine synthase activity
D1092_RS03430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1092_RS03435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1092_RS03445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1092_RS03455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1092_RS03475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1092_RS03480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1092_RS03485	COG0628	permease
D1092_RS03570	COG2801	Transposase and inactivated derivatives
D1092_RS03575	COG2842	Transposition protein
D1092_RS03605	COG3179	chitinase
D1092_RS03645	COG4383	Mu-like prophage protein gp29
D1092_RS03650	COG2369	cell adhesion
D1092_RS03765	COG0582	viral genome integration into host DNA
D1092_RS03825	COG0629	single-stranded DNA binding
D1092_RS03990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1092_RS03995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1092_RS04000	COG0649	NAD binding
D1092_RS04005	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D1092_RS04010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1092_RS04020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1092_RS04025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1092_RS04035	COG0713	ATP synthesis coupled electron transport
D1092_RS04050	COG1007	ATP synthesis coupled electron transport
D1092_RS04065	COG0442	prolyl-tRNA aminoacylation
D1092_RS04075	COG1136	(ABC) transporter
D1092_RS04080	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D1092_RS04085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1092_RS04095	COG1530	ribonuclease E activity
D1092_RS04105	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1092_RS04110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1092_RS04125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1092_RS04130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1092_RS04135	COG2945	thiolester hydrolase activity
D1092_RS04145	COG0719	Fe-S assembly protein
D1092_RS04150	COG0396	ATPase activity
D1092_RS04155	COG0719	Fe-S assembly protein
D1092_RS04160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1092_RS04170	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D1092_RS04190	COG2032	superoxide dismutase activity
D1092_RS04205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1092_RS04210	COG1183	phosphatidylcholine synthase activity
D1092_RS04230	COG0321	lipoyl(octanoyl) transferase activity
D1092_RS04230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D1092_RS04235	COG0084	hydrolase, TatD family'
D1092_RS04250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1092_RS04270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1092_RS04275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1092_RS04280	COG0037	tRNA processing
D1092_RS04285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1092_RS04290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1092_RS04295	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1092_RS04300	COG1489	DNA binding
D1092_RS04305	COG0024	Methionine aminopeptidase
D1092_RS04320	COG0596	Alpha beta hydrolase
D1092_RS04330	COG1278	Cold shock
D1092_RS04340	COG0559	Belongs to the binding-protein-dependent transport system permease family
D1092_RS04360	COG0154	amidase activity
D1092_RS04365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1092_RS04370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1092_RS04380	COG0540	Belongs to the ATCase OTCase family
D1092_RS04385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1092_RS04390	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1092_RS04395	COG0758	DNA mediated transformation
D1092_RS04405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1092_RS04410	COG0557	exoribonuclease II activity
D1092_RS04420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1092_RS04430	COG1573	uracil-dna glycosylase
D1092_RS04435	COG1522	sequence-specific DNA binding
D1092_RS04440	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1092_RS04445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1092_RS04465	COG0511	ligase activity, forming carbon-carbon bonds
D1092_RS04535	COG0741	lytic transglycosylase activity
D1092_RS04570	COG3657	addiction module killer protein
D1092_RS04575	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1092_RS04600	COG0582	viral genome integration into host DNA
D1092_RS04635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1092_RS04665	COG0629	single-stranded DNA binding
D1092_RS04670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1092_RS04800	COG0302	gtp cyclohydrolase
D1092_RS04810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1092_RS04815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1092_RS04825	COG0776	regulation of translation
D1092_RS04830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1092_RS04835	COG0416	fatty acid biosynthetic process
D1092_RS04850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1092_RS04855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1092_RS04865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1092_RS04865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1092_RS04870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1092_RS04875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1092_RS04885	COG1612	heme a metabolic process
D1092_RS04895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1092_RS04900	COG1923	regulation of RNA biosynthetic process
D1092_RS04910	COG0281	malic enzyme
D1092_RS04910	COG0280	phosphate acetyltransferase
D1092_RS04915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1092_RS04925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1092_RS04930	COG1063	alcohol dehydrogenase
D1092_RS04940	COG3956	TIGRFAM MazG family protein
D1092_RS04955	COG0071	Belongs to the small heat shock protein (HSP20) family
D1092_RS05020	COG3210	domain, Protein
D1092_RS05045	COG2986	histidine ammonia-lyase
D1092_RS05060	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D1092_RS05065	COG0321	lipoyl(octanoyl) transferase activity
D1092_RS05070	COG0187	DNA topoisomerase II activity
D1092_RS05080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1092_RS05085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1092_RS05090	COG0784	Response regulator, receiver
D1092_RS05120	COG1132	(ABC) transporter
D1092_RS05125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1092_RS05130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1092_RS05140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1092_RS05145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1092_RS05150	COG0203	ribosomal protein L17
D1092_RS05155	COG0202	RNA polymerase activity
D1092_RS05160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1092_RS05165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1092_RS05170	COG0563	adenylate kinase activity
D1092_RS05175	COG0201	protein transport
D1092_RS05180	COG0200	Binds to the 23S rRNA
D1092_RS05185	COG1841	ribosomal large subunit assembly
D1092_RS05190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1092_RS05195	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1092_RS05200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1092_RS05205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1092_RS05210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1092_RS05215	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1092_RS05220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1092_RS05225	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1092_RS05230	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1092_RS05235	COG0255	Belongs to the universal ribosomal protein uL29 family
D1092_RS05240	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1092_RS05245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1092_RS05250	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1092_RS05255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1092_RS05260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1092_RS05265	COG0089	rRNA binding
D1092_RS05270	COG0088	Forms part of the polypeptide exit tunnel
D1092_RS05275	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1092_RS05280	COG0051	transcription antitermination factor activity, RNA binding
D1092_RS05285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1092_RS05290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1092_RS05295	COG0049	tRNA binding
D1092_RS05300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1092_RS05315	COG0765	amino acid transport
D1092_RS05320	COG0765	amino acid transport
D1092_RS05325	COG1126	abc transporter atp-binding protein
D1092_RS05340	COG0525	valine-tRNA ligase activity
D1092_RS05355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1092_RS05370	COG0513	Belongs to the DEAD box helicase family
D1092_RS05380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1092_RS05390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1092_RS05400	COG1196	nuclear chromosome segregation
D1092_RS05400	COG3264	Mechanosensitive ion channel
D1092_RS05415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1092_RS05415	COG4651	solute:proton antiporter activity
D1092_RS05420	COG0392	lysyltransferase activity
D1092_RS05420	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D1092_RS05430	COG1253	flavin adenine dinucleotide binding
D1092_RS05445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1092_RS05455	COG1280	lysine exporter protein (LysE YggA)
D1092_RS05460	COG1113	amino acid transport
D1092_RS05465	COG1113	amino acid transport
D1092_RS05470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1092_RS05480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1092_RS05485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1092_RS05505	COG0028	Belongs to the TPP enzyme family
D1092_RS05510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1092_RS05515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1092_RS05520	COG0330	HflC and HflK could
D1092_RS05535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D1092_RS05540	COG0477	Major facilitator Superfamily
D1092_RS05545	COG0477	Major facilitator Superfamily
D1092_RS05550	COG0477	Major facilitator Superfamily
D1092_RS05555	COG0477	Major facilitator Superfamily
D1092_RS05585	COG0210	DNA helicase
D1092_RS05595	COG1999	signal sequence binding
D1092_RS05605	COG0006	proline dipeptidase activity
D1092_RS05610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1092_RS05615	COG0497	DNA recombination
D1092_RS05620	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1092_RS05635	COG0849	cell division
D1092_RS05645	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1092_RS05650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1092_RS05655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1092_RS05660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1092_RS05670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1092_RS05675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1092_RS05700	COG0275	rRNA processing
D1092_RS05725	COG2226	methyltransferase
D1092_RS05740	COG1335	isochorismatase
D1092_RS05780	COG2968	Membrane
D1092_RS05790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1092_RS05795	COG0358	DNA primase activity
D1092_RS05800	COG0668	transmembrane transport
D1092_RS05815	COG3161	chorismate lyase activity
D1092_RS05825	COG0505	Belongs to the CarA family
D1092_RS05840	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D1092_RS05855	COG0482	sulfurtransferase activity
D1092_RS05945	COG3468	outer membrane autotransporter barrel domain protein
D1092_RS05980	COG1192	Involved in chromosome partitioning
D1092_RS05990	COG0196	riboflavin kinase activity
D1092_RS06000	COG1396	sequence-specific DNA binding
D1092_RS06010	COG3838	Conjugal transfer protein Trbc
D1092_RS06015	COG3702	type iv secretory pathway
D1092_RS06020	COG3451	type IV secretory pathway VirB4
D1092_RS06030	COG3704	protein secretion by the type IV secretion system
D1092_RS06040	COG3736	Type IV secretory pathway, component VirB8
D1092_RS06045	COG3504	Conjugal transfer protein
D1092_RS06050	COG2948	multi-organism process
D1092_RS06055	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D1092_RS06065	COG2184	nucleotidyltransferase activity
D1092_RS06070	COG3505	Type IV secretory pathway VirD4
D1092_RS06075	COG2184	nucleotidyltransferase activity
D1092_RS06100	COG2184	nucleotidyltransferase activity
D1092_RS06105	COG0728	peptidoglycan biosynthetic process
D1092_RS06110	COG0180	Tryptophanyl-tRNA synthetase
D1092_RS06120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D1092_RS06125	COG2824	Alkylphosphonate utilization operon protein PhnA
D1092_RS06135	COG0033	Phosphoglucomutase
D1092_RS06145	COG0124	histidyl-tRNA synthetase
D1092_RS06155	COG0284	orotidine-5'-phosphate decarboxylase activity
D1092_RS06200	COG0735	belongs to the Fur family
D1092_RS06225	COG1054	Belongs to the UPF0176 family
D1092_RS06230	COG0800	Aldolase
D1092_RS06250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1092_RS06250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1092_RS06255	COG0509	glycine decarboxylation via glycine cleavage system
D1092_RS06260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1092_RS06270	COG2835	tetraacyldisaccharide 4'-kinase activity
D1092_RS06275	COG1396	sequence-specific DNA binding
D1092_RS06280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1092_RS06295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1092_RS06300	COG2011	ABC-type metal ion transport system permease component
D1092_RS06390	COG4607	ABC-type enterochelin transport system periplasmic component
D1092_RS06395	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1092_RS06400	COG4605	iron ion homeostasis
D1092_RS06405	COG4604	ABC transporter, ATP-binding protein
D1092_RS06440	COG0444	Belongs to the ABC transporter superfamily
D1092_RS06445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1092_RS06450	COG0601	transmembrane transport
D1092_RS06455	COG0747	negative chemotaxis
D1092_RS06465	COG2818	Glycosylase
D1092_RS06470	COG1570	exodeoxyribonuclease VII activity
D1092_RS06480	COG0747	negative chemotaxis
D1092_RS06505	COG0730	response to heat
D1092_RS06515	COG2086	electron transfer activity
D1092_RS06530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1092_RS06535	COG0792	nuclease activity
D1092_RS06550	COG0489	protein tyrosine kinase activity
D1092_RS06555	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1092_RS06560	COG0594	ribonuclease P activity
D1092_RS06570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D1092_RS06585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1092_RS06590	COG0588	phosphoglycerate mutase activity
D1092_RS06635	COG3023	N-Acetylmuramoyl-L-alanine amidase
D1092_RS06645	COG2814	Major facilitator Superfamily
D1092_RS06685	COG0156	8-amino-7-oxononanoate synthase activity
D1092_RS06705	COG0477	Major facilitator Superfamily
D1092_RS06785	COG3920	Histidine kinase
D1092_RS06800	COG0784	Response regulator, receiver
D1092_RS06805	COG3920	Histidine kinase
D1092_RS06805	COG2202	Pas domain
D1092_RS06905	COG1396	sequence-specific DNA binding
D1092_RS06915	COG1396	sequence-specific DNA binding
D1092_RS06920	COG1396	sequence-specific DNA binding
D1092_RS06995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D1092_RS07000	COG0424	maF-like protein
D1092_RS07005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1092_RS07010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1092_RS07015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1092_RS07025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1092_RS07035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1092_RS07040	COG0457	Tetratricopeptide repeat
D1092_RS07060	COG1692	metallophosphoesterase
D1092_RS07070	COG0473	3-isopropylmalate dehydrogenase activity
D1092_RS07070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1092_RS07080	COG1396	sequence-specific DNA binding
D1092_RS07095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1092_RS07340	COG0459	protein refolding
D1092_RS07345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1092_RS07365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1092_RS07375	COG1238	metal cluster binding
D1092_RS07405	COG0756	dUTP diphosphatase activity
D1092_RS07410	COG0848	biopolymer transport protein
D1092_RS07415	COG0811	peptide transport
D1092_RS07445	COG3702	type iv secretory pathway
D1092_RS07450	COG3451	type IV secretory pathway VirB4
D1092_RS07510	COG3704	protein secretion by the type IV secretion system
D1092_RS07520	COG3736	Type IV secretory pathway, component VirB8
D1092_RS07525	COG3504	Conjugal transfer protein
D1092_RS07530	COG2948	multi-organism process
D1092_RS07535	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D1092_RS07575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1092_RS07580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1092_RS07585	COG0037	tRNA processing
D1092_RS07595	COG2885	chlorophyll binding
D1092_RS07605	COG0217	transcriptional regulatory protein
D1092_RS07610	COG0823	Involved in the tonB-independent uptake of proteins
D1092_RS07635	COG0824	Thioesterase
D1092_RS07640	COG2255	four-way junction helicase activity
D1092_RS07645	COG0632	four-way junction helicase activity
D1092_RS07650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1092_RS07680	COG1396	sequence-specific DNA binding
D1092_RS07700	COG1396	sequence-specific DNA binding
D1092_RS07725	COG1396	sequence-specific DNA binding
D1092_RS07730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1092_RS07735	COG0483	inositol monophosphate 1-phosphatase activity
D1092_RS07745	COG1132	(ABC) transporter
D1092_RS07750	COG0254	rRNA binding
D1092_RS07770	COG3588	fructose-bisphosphate aldolase
D1092_RS07775	COG0126	phosphoglycerate kinase activity
D1092_RS07800	COG0469	pyruvate kinase activity
D1092_RS07810	COG3750	Belongs to the UPF0335 family
D1092_RS07815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1092_RS07820	COG0488	(ABC) transporter
D1092_RS07835	COG4783	chaperone-mediated protein folding
D1092_RS07840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1092_RS07850	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D1092_RS07860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1092_RS07865	COG0142	geranyltranstransferase activity
D1092_RS07875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1092_RS07895	COG1566	PFAM secretion protein HlyD family protein
D1092_RS07905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1092_RS07910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1092_RS07915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1092_RS07920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1092_RS07925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1092_RS07945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1092_RS07955	COG0495	leucyl-tRNA aminoacylation
D1092_RS07970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1092_RS07975	COG2884	Cell division ATP-binding protein ftsE
D1092_RS07995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1092_RS08000	COG1674	ftsk spoiiie
D1092_RS08020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1092_RS08025	COG1136	(ABC) transporter
D1092_RS08025	COG0577	efflux transmembrane transporter activity
D1092_RS08215	COG2948	multi-organism process
D1092_RS08245	COG0335	large ribosomal subunit rRNA binding
D1092_RS08250	COG0336	Belongs to the RNA methyltransferase TrmD family
D1092_RS08255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1092_RS08335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1092_RS08345	COG0138	bifunctional purine biosynthesis protein purh
D1092_RS08360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1092_RS08360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1092_RS08365	COG0501	Belongs to the peptidase M48B family
D1092_RS08375	COG0228	four-way junction DNA binding
D1092_RS08385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1092_RS08390	COG0288	reversible hydration of carbon dioxide
D1092_RS08395	COG2902	Dehydrogenase
D1092_RS08425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1092_RS08435	COG0745	RESPONSE REGULATOR receiver
D1092_RS08460	COG0165	Argininosuccinate lyase
D1092_RS08470	COG1671	Belongs to the UPF0178 family
D1092_RS08480	COG0287	Prephenate dehydrogenase
D1092_RS08490	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D1092_RS08530	COG1686	Belongs to the peptidase S11 family
D1092_RS08535	COG0523	cobalamin synthesis protein
D1092_RS08540	COG3034	peptidoglycan biosynthetic process
D1092_RS08545	COG0825	malonyl-CoA metabolic process
D1092_RS08555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1092_RS08560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1092_RS08570	COG3895	Periplasmic Protein
D1092_RS08575	COG1320	monovalent cation:proton antiporter activity
D1092_RS08580	COG2212	antiporter activity
D1092_RS08585	COG1863	multisubunit Na H antiporter MnhE subunit
D1092_RS08590	COG0651	ATP synthesis coupled electron transport
D1092_RS08595	COG1006	Multisubunit Na H antiporter MnhC subunit
D1092_RS08600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1092_RS08600	COG2111	Na H antiporter
D1092_RS08610	COG0019	diaminopimelate decarboxylase activity
D1092_RS08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1092_RS08630	COG0567	Dehydrogenase, E1 component
D1092_RS08640	COG0045	succinate-CoA ligase (ADP-forming) activity
D1092_RS08645	COG0039	L-malate dehydrogenase activity
D1092_RS08650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1092_RS08660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1092_RS08665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1092_RS08670	COG0552	protein localization to endoplasmic reticulum
D1092_RS08680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1092_RS08700	COG0357	Ribosomal RNA small subunit methyltransferase G
D1092_RS08705	COG0445	tRNA wobble uridine modification
D1092_RS08710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D1092_RS08715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1092_RS08720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D1092_RS08725	COG0424	maF-like protein
D1092_RS08730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1092_RS08735	COG0237	dephospho-CoA kinase activity
D1092_RS08745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1092_RS08745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1092_RS08755	COG0670	Belongs to the BI1 family
D1092_RS08760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1092_RS08770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1092_RS08770	COG0116	Belongs to the methyltransferase superfamily
D1092_RS08780	COG0776	regulation of translation
D1092_RS08795	COG1137	ATPase activity
D1092_RS08800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1092_RS08810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1092_RS08820	COG0137	argininosuccinate synthase activity
D1092_RS08830	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D1092_RS08835	COG2887	Belongs to the helicase family. UvrD subfamily
D1092_RS08850	COG0802	atpase or kinase
D1092_RS08855	COG2205	protein histidine kinase activity
D1092_RS08860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1092_RS08865	COG0702	epimerase
D1092_RS08870	COG0285	dihydrofolate synthase activity
D1092_RS08875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1092_RS08885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1092_RS08890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1092_RS08895	COG2226	methyltransferase
D1092_RS08910	COG0606	chelatase, subunit chli
D1092_RS08925	COG1132	(ABC) transporter
D1092_RS08930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1092_RS08945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1092_RS08950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1092_RS08955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1092_RS08960	COG1420	regulation of RNA biosynthetic process
D1092_RS08965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1092_RS08980	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1092_RS08980	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1092_RS08990	COG2205	protein histidine kinase activity
D1092_RS08995	COG0745	RESPONSE REGULATOR receiver
D1092_RS09000	COG1652	LysM domain
D1092_RS09010	COG0443	Heat shock 70 kDa protein
D1092_RS09015	COG0484	heat shock protein binding
D1092_RS09025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1092_RS09035	COG0481	GTPase activity
D1092_RS09040	COG2171	N-acyltransferase activity
D1092_RS09050	COG0101	tRNA pseudouridine synthase activity
D1092_RS09055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1092_RS09060	COG0242	peptide deformylase activity
D1092_RS09085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1092_RS09090	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1092_RS09095	COG0539	negative regulation of cytoplasmic translation
D1092_RS09100	COG3459	Glycosyltransferase 36 associated
D1092_RS09105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D1092_RS09110	COG2832	Protein of unknown function (DUF454)
D1092_RS09115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1092_RS09120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1092_RS09125	COG1121	(ABC) transporter
D1092_RS09135	COG0072	phenylalanine-tRNA ligase activity
D1092_RS09135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1092_RS09140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1092_RS09145	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1092_RS09150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1092_RS09170	COG0129	dihydroxy-acid dehydratase activity
D1092_RS09175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D1092_RS09180	COG0281	malic enzyme
D1092_RS09180	COG0280	phosphate acetyltransferase
D1092_RS09185	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D1092_RS09190	COG3030	protein affecting phage T7 exclusion by the F plasmid
D1092_RS09210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1092_RS09225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1092_RS09235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1092_RS09240	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1092_RS09245	COG4133	protoheme IX ABC transporter activity
D1092_RS09250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1092_RS09255	COG0268	Binds directly to 16S ribosomal RNA