locus-tag	class	description
D1093_RS00010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1093_RS00020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1093_RS00030	COG0459	protein refolding
D1093_RS00035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1093_RS00050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1093_RS00080	COG1238	metal cluster binding
D1093_RS00115	COG0756	dUTP diphosphatase activity
D1093_RS00125	COG0848	biopolymer transport protein
D1093_RS00150	COG3838	Conjugal transfer protein Trbc
D1093_RS00155	COG3702	type iv secretory pathway
D1093_RS00160	COG3451	type IV secretory pathway VirB4
D1093_RS00230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1093_RS00235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1093_RS00240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1093_RS00245	COG0037	tRNA processing
D1093_RS00255	COG2885	chlorophyll binding
D1093_RS00265	COG0217	transcriptional regulatory protein
D1093_RS00270	COG0823	Involved in the tonB-independent uptake of proteins
D1093_RS00290	COG1396	sequence-specific DNA binding
D1093_RS00295	COG1396	sequence-specific DNA binding
D1093_RS00300	COG0824	Thioesterase
D1093_RS00305	COG2255	four-way junction helicase activity
D1093_RS00310	COG0632	four-way junction helicase activity
D1093_RS00315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1093_RS00345	COG1396	sequence-specific DNA binding
D1093_RS00350	COG1396	sequence-specific DNA binding
D1093_RS00375	COG1396	sequence-specific DNA binding
D1093_RS00380	COG1396	sequence-specific DNA binding
D1093_RS00385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1093_RS00390	COG0483	inositol monophosphate 1-phosphatase activity
D1093_RS00410	COG1132	(ABC) transporter
D1093_RS00415	COG0254	rRNA binding
D1093_RS00430	COG3588	fructose-bisphosphate aldolase
D1093_RS00435	COG0126	phosphoglycerate kinase activity
D1093_RS00475	COG0469	pyruvate kinase activity
D1093_RS00485	COG3750	Belongs to the UPF0335 family
D1093_RS00490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1093_RS00495	COG0488	(ABC) transporter
D1093_RS00510	COG4783	chaperone-mediated protein folding
D1093_RS00515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1093_RS00525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D1093_RS00535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1093_RS00540	COG0142	geranyltranstransferase activity
D1093_RS00550	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1093_RS00560	COG1566	PFAM secretion protein HlyD family protein
D1093_RS00570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1093_RS00575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1093_RS00580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1093_RS00585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1093_RS00590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1093_RS00610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1093_RS00620	COG0495	leucyl-tRNA aminoacylation
D1093_RS00655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1093_RS00660	COG2884	Cell division ATP-binding protein ftsE
D1093_RS00685	COG1136	(ABC) transporter
D1093_RS00685	COG0577	efflux transmembrane transporter activity
D1093_RS00690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1093_RS00715	COG1674	ftsk spoiiie
D1093_RS00720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1093_RS00875	COG2948	multi-organism process
D1093_RS00905	COG0335	large ribosomal subunit rRNA binding
D1093_RS00910	COG0336	Belongs to the RNA methyltransferase TrmD family
D1093_RS00915	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1093_RS00925	COG4974	Belongs to the 'phage' integrase family
D1093_RS00955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1093_RS00965	COG0138	bifunctional purine biosynthesis protein purh
D1093_RS00990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1093_RS00990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1093_RS00995	COG0501	Belongs to the peptidase M48B family
D1093_RS01005	COG0228	four-way junction DNA binding
D1093_RS01015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1093_RS01020	COG0288	reversible hydration of carbon dioxide
D1093_RS01025	COG2902	Dehydrogenase
D1093_RS01055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1093_RS01065	COG0745	RESPONSE REGULATOR receiver
D1093_RS01090	COG0165	Argininosuccinate lyase
D1093_RS01095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1093_RS01100	COG1671	Belongs to the UPF0178 family
D1093_RS01110	COG0287	Prephenate dehydrogenase
D1093_RS01120	COG1122	ATPase activity
D1093_RS01165	COG1686	Belongs to the peptidase S11 family
D1093_RS01170	COG0523	cobalamin synthesis protein
D1093_RS01175	COG3034	peptidoglycan biosynthetic process
D1093_RS01180	COG0825	malonyl-CoA metabolic process
D1093_RS01190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1093_RS01195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1093_RS01205	COG3895	Periplasmic Protein
D1093_RS01210	COG1320	monovalent cation:proton antiporter activity
D1093_RS01215	COG2212	antiporter activity
D1093_RS01220	COG1863	multisubunit Na H antiporter MnhE subunit
D1093_RS01225	COG0651	ATP synthesis coupled electron transport
D1093_RS01230	COG1006	Multisubunit Na H antiporter MnhC subunit
D1093_RS01235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1093_RS01235	COG2111	Na H antiporter
D1093_RS01245	COG0019	diaminopimelate decarboxylase activity
D1093_RS01260	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1093_RS01265	COG0567	Dehydrogenase, E1 component
D1093_RS01275	COG0045	succinate-CoA ligase (ADP-forming) activity
D1093_RS01280	COG0039	L-malate dehydrogenase activity
D1093_RS01285	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1093_RS01295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1093_RS01300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1093_RS01305	COG0552	protein localization to endoplasmic reticulum
D1093_RS01315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1093_RS01340	COG0357	Ribosomal RNA small subunit methyltransferase G
D1093_RS01345	COG0445	tRNA wobble uridine modification
D1093_RS01350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D1093_RS01355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1093_RS01360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D1093_RS01365	COG0424	maF-like protein
D1093_RS01370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1093_RS01375	COG0237	dephospho-CoA kinase activity
D1093_RS01380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1093_RS01385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1093_RS01385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1093_RS01395	COG0670	Belongs to the BI1 family
D1093_RS01400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1093_RS01410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1093_RS01410	COG0116	Belongs to the methyltransferase superfamily
D1093_RS01420	COG0776	regulation of translation
D1093_RS01435	COG1137	ATPase activity
D1093_RS01440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1093_RS01450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1093_RS01470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D1093_RS01475	COG2887	Belongs to the helicase family. UvrD subfamily
D1093_RS01490	COG0802	atpase or kinase
D1093_RS01495	COG2205	protein histidine kinase activity
D1093_RS01500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1093_RS01505	COG0702	epimerase
D1093_RS01510	COG0285	dihydrofolate synthase activity
D1093_RS01515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1093_RS01525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1093_RS01530	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1093_RS01535	COG2226	methyltransferase
D1093_RS01550	COG0606	chelatase, subunit chli
D1093_RS01565	COG1132	(ABC) transporter
D1093_RS01570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1093_RS01585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1093_RS01590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1093_RS01595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1093_RS01600	COG1420	regulation of RNA biosynthetic process
D1093_RS01605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1093_RS01620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1093_RS01620	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1093_RS01630	COG2205	protein histidine kinase activity
D1093_RS01635	COG0745	RESPONSE REGULATOR receiver
D1093_RS01640	COG1652	LysM domain
D1093_RS01650	COG0443	Heat shock 70 kDa protein
D1093_RS01655	COG0484	heat shock protein binding
D1093_RS01660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1093_RS01670	COG0481	GTPase activity
D1093_RS01675	COG2171	N-acyltransferase activity
D1093_RS01685	COG0101	tRNA pseudouridine synthase activity
D1093_RS01690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1093_RS01695	COG0242	peptide deformylase activity
D1093_RS01720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1093_RS01725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1093_RS01730	COG0539	negative regulation of cytoplasmic translation
D1093_RS01735	COG3459	Glycosyltransferase 36 associated
D1093_RS01740	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D1093_RS01745	COG2832	Protein of unknown function (DUF454)
D1093_RS01750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1093_RS01755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1093_RS01760	COG1121	(ABC) transporter
D1093_RS01770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1093_RS01770	COG0072	phenylalanine-tRNA ligase activity
D1093_RS01775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1093_RS01780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1093_RS01785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1093_RS01805	COG0129	dihydroxy-acid dehydratase activity
D1093_RS01815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D1093_RS01820	COG0281	malic enzyme
D1093_RS01820	COG0280	phosphate acetyltransferase
D1093_RS01825	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D1093_RS01830	COG3030	protein affecting phage T7 exclusion by the F plasmid
D1093_RS01850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1093_RS01870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1093_RS01880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1093_RS01885	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1093_RS01890	COG4133	protoheme IX ABC transporter activity
D1093_RS01895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1093_RS01900	COG0268	Binds directly to 16S ribosomal RNA
D1093_RS01905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1093_RS01920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1093_RS01930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1093_RS01935	COG1845	cytochrome c oxidase, subunit III
D1093_RS01940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D1093_RS01945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1093_RS01950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1093_RS01960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1093_RS01975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1093_RS01980	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D1093_RS01995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1093_RS02000	COG0166	Belongs to the GPI family
D1093_RS02015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1093_RS02020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1093_RS02025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1093_RS02025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1093_RS02050	COG2814	Major facilitator Superfamily
D1093_RS02115	COG0248	Ppx GppA phosphatase
D1093_RS02120	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1093_RS02125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1093_RS02130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1093_RS02135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1093_RS02140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1093_RS02145	COG0799	negative regulation of ribosome biogenesis
D1093_RS02150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1093_RS02160	COG0793	Belongs to the peptidase S41A family
D1093_RS02165	COG0494	nUDIX hydrolase
D1093_RS02170	COG5342	invasion associated locus B
D1093_RS02180	COG1872	DUF167
D1093_RS02185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1093_RS02190	COG1217	gtp-binding protein TYPA
D1093_RS02195	COG2239	Acts as a magnesium transporter
D1093_RS02200	COG0339	signal peptide processing
D1093_RS02210	COG2951	lytic endotransglycosylase activity
D1093_RS02215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1093_RS02220	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1093_RS02220	COG0517	IMP dehydrogenase activity
D1093_RS02235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1093_RS02250	COG0519	Catalyzes the synthesis of GMP from XMP
D1093_RS02250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1093_RS02255	COG0584	glycerophosphoryl diester phosphodiesterase
D1093_RS02270	COG0395	ABC-type sugar transport system, permease component
D1093_RS02275	COG3842	ATPase activity
D1093_RS02280	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1093_RS02290	COG1121	(ABC) transporter
D1093_RS02300	COG1780	Probably involved in ribonucleotide reductase function
D1093_RS02305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1093_RS02315	COG2890	protein-(glutamine-N5) methyltransferase activity
D1093_RS02320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1093_RS02330	COG0653	protein targeting
D1093_RS02335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1093_RS02340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1093_RS02345	COG0494	nUDIX hydrolase
D1093_RS02355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1093_RS02360	COG1072	(Pantothenic acid kinase))
D1093_RS02365	COG0252	asparaginase activity
D1093_RS02370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D1093_RS02375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D1093_RS02380	COG2813	Specifically methylates the guanine in position
D1093_RS02385	COG1185	polyribonucleotide nucleotidyltransferase activity
D1093_RS02390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1093_RS02400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1093_RS02405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1093_RS02410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1093_RS02420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1093_RS02420	COG0195	Participates in both transcription termination and antitermination
D1093_RS02425	COG0779	Required for maturation of 30S ribosomal subunits
D1093_RS02430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1093_RS02435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1093_RS02440	COG1396	sequence-specific DNA binding
D1093_RS02445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1093_RS02455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1093_RS02460	COG1702	phosphate starvation-inducible protein PhoH
D1093_RS02465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1093_RS02470	COG0456	acetyltransferase
D1093_RS02475	COG1214	PFAM Peptidase M22, glycoprotease
D1093_RS02480	COG2855	membrane
D1093_RS02485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1093_RS02490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1093_RS02510	COG1605	Chorismate mutase
D1093_RS02510	COG0077	Prephenate dehydratase
D1093_RS02515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D1093_RS02520	COG3474	cytochrome
D1093_RS02525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1093_RS02530	COG0189	ligase activity
D1093_RS02540	COG0573	inorganic phosphate transmembrane transporter activity
D1093_RS02550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1093_RS02555	COG0704	Plays a role in the regulation of phosphate uptake
D1093_RS02570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1093_RS02580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1093_RS02590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1093_RS02595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1093_RS02600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1093_RS02605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1093_RS02615	COG0590	tRNA wobble adenosine to inosine editing
D1093_RS02620	COG1187	pseudouridine synthase activity
D1093_RS02625	COG0742	ribosomal rna small subunit methyltransferase
D1093_RS02640	COG0312	modulator of DNA gyrase
D1093_RS02645	COG0483	inositol monophosphate 1-phosphatase activity
D1093_RS02655	COG1519	Transferase
D1093_RS02660	COG1663	tetraacyldisaccharide 4'-kinase activity
D1093_RS02670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D1093_RS02675	COG0717	Belongs to the dCTP deaminase family
D1093_RS02680	COG1304	FMN binding
D1093_RS02725	COG1113	amino acid transport
D1093_RS02730	COG1122	ATPase activity
D1093_RS02735	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D1093_RS02740	COG1268	BioY protein
D1093_RS02755	COG0582	viral genome integration into host DNA
D1093_RS02770	COG3077	Addiction module antitoxin, RelB DinJ family
D1093_RS02775	COG3041	Addiction module toxin RelE StbE family
D1093_RS02820	COG3561	AntA/AntB antirepressor
D1093_RS03010	COG3077	Addiction module antitoxin, RelB DinJ family
D1093_RS03015	COG3041	Addiction module toxin RelE StbE family
D1093_RS03025	COG3561	AntA/AntB antirepressor
D1093_RS03050	COG1598	PFAM Uncharacterised protein family UPF0150
D1093_RS03060	COG0629	single-stranded DNA binding
D1093_RS03100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1093_RS03175	COG3561	AntA/AntB antirepressor
D1093_RS03185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1093_RS03195	COG0513	Belongs to the DEAD box helicase family
D1093_RS03235	COG3561	AntA/AntB antirepressor
D1093_RS03295	COG0629	single-stranded DNA binding
D1093_RS03350	COG0582	viral genome integration into host DNA
D1093_RS03370	COG0582	viral genome integration into host DNA
D1093_RS03430	COG3657	addiction module killer protein
D1093_RS03465	COG0741	lytic transglycosylase activity
D1093_RS03535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1093_RS03550	COG0525	valine-tRNA ligase activity
D1093_RS03555	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D1093_RS03560	COG1126	abc transporter atp-binding protein
D1093_RS03565	COG0765	amino acid transport
D1093_RS03570	COG0765	amino acid transport
D1093_RS03585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1093_RS03590	COG0049	tRNA binding
D1093_RS03595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1093_RS03600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1093_RS03605	COG0051	transcription antitermination factor activity, RNA binding
D1093_RS03610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1093_RS03615	COG0088	Forms part of the polypeptide exit tunnel
D1093_RS03620	COG0089	rRNA binding
D1093_RS03625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1093_RS03630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1093_RS03635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1093_RS03640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1093_RS03645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1093_RS03650	COG0255	Belongs to the universal ribosomal protein uL29 family
D1093_RS03655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1093_RS03660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1093_RS03665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1093_RS03670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1093_RS03675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1093_RS03680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1093_RS03685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1093_RS03690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1093_RS03695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1093_RS03700	COG1841	ribosomal large subunit assembly
D1093_RS03705	COG0200	Binds to the 23S rRNA
D1093_RS03710	COG0201	protein transport
D1093_RS03715	COG0563	adenylate kinase activity
D1093_RS03720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1093_RS03725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1093_RS03730	COG0202	RNA polymerase activity
D1093_RS03735	COG0203	ribosomal protein L17
D1093_RS03740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1093_RS03745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1093_RS03750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1093_RS03755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1093_RS03760	COG1132	(ABC) transporter
D1093_RS03795	COG0784	Response regulator, receiver
D1093_RS03800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1093_RS03805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1093_RS03815	COG0187	DNA topoisomerase II activity
D1093_RS03820	COG0321	lipoyl(octanoyl) transferase activity
D1093_RS03825	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D1093_RS03835	COG2986	histidine ammonia-lyase
D1093_RS03905	COG0174	glutamine synthetase
D1093_RS03910	COG0347	Belongs to the P(II) protein family
D1093_RS03920	COG0629	single-stranded DNA binding
D1093_RS03925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1093_RS03930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1093_RS03945	COG0343	queuine tRNA-ribosyltransferase activity
D1093_RS03950	COG2814	Major facilitator Superfamily
D1093_RS03960	COG0538	isocitrate dehydrogenase activity
D1093_RS03975	COG1494	fructose-1,6-bisphosphatase
D1093_RS03980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1093_RS03995	COG0018	arginyl-trna synthetase
D1093_RS04000	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1093_RS04005	COG0316	Belongs to the HesB IscA family
D1093_RS04015	COG0785	Cytochrome C biogenesis protein
D1093_RS04020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1093_RS04025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1093_RS04030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1093_RS04040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1093_RS04050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1093_RS04055	COG0248	Ppx GppA phosphatase
D1093_RS04060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1093_RS04065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1093_RS04070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1093_RS04075	COG2814	Major facilitator Superfamily
D1093_RS04080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1093_RS04090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1093_RS04095	COG0047	phosphoribosylformylglycinamidine synthase activity
D1093_RS04100	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1093_RS04105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1093_RS04115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1093_RS04125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1093_RS04145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1093_RS04150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1093_RS04155	COG0628	permease
D1093_RS04215	COG3561	AntA/AntB antirepressor
D1093_RS04275	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1093_RS04280	COG0629	single-stranded DNA binding
D1093_RS04290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1093_RS04315	COG3210	domain, Protein
D1093_RS04315	COG3210	domain, Protein
D1093_RS04325	COG3210	domain, Protein
D1093_RS04350	COG3210	domain, Protein
D1093_RS04380	COG1598	PFAM Uncharacterised protein family UPF0150
D1093_RS04385	COG3561	AntA/AntB antirepressor
D1093_RS04415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1093_RS04490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1093_RS04500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1093_RS04505	COG0564	pseudouridine synthase activity
D1093_RS04525	COG1970	mechanosensitive ion channel activity
D1093_RS04535	COG0167	dihydroorotate dehydrogenase activity
D1093_RS04630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1093_RS04635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1093_RS04640	COG0363	glucosamine-6-phosphate deaminase activity
D1093_RS04645	COG0129	dihydroxy-acid dehydratase activity
D1093_RS04650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1093_RS04675	COG1823	symporter activity
D1093_RS04680	COG2226	methyltransferase
D1093_RS04685	COG1040	competence protein
D1093_RS04690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1093_RS04695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1093_RS04700	COG0527	aspartate kinase activity
D1093_RS04715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1093_RS04725	COG3273	potassium ion transport
D1093_RS04725	COG0471	metal ion transport
D1093_RS04735	COG1160	GTP binding
D1093_RS04745	COG0356	it plays a direct role in the translocation of protons across the membrane
D1093_RS04755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1093_RS04760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1093_RS04765	COG0751	glycine-tRNA ligase activity
D1093_RS04780	COG0142	geranyltranstransferase activity
D1093_RS04795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1093_RS04800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1093_RS04805	COG0009	L-threonylcarbamoyladenylate synthase
D1093_RS04810	COG0277	FAD linked oxidase domain protein
D1093_RS04825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1093_RS04830	COG0259	pyridoxamine-phosphate oxidase activity
D1093_RS04835	COG0484	heat shock protein binding
D1093_RS04840	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1093_RS04845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1093_RS04850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1093_RS04850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1093_RS04855	COG1722	exodeoxyribonuclease VII activity
D1093_RS04860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1093_RS04880	COG0312	modulator of DNA gyrase
D1093_RS04890	COG0109	protoheme IX farnesyltransferase activity
D1093_RS04895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1093_RS04900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D1093_RS04905	COG0328	RNA-DNA hybrid ribonuclease activity
D1093_RS04915	COG1678	Uncharacterized ACR, COG1678
D1093_RS04920	COG5001	Diguanylate cyclase
D1093_RS04920	COG1716	ATPase activity
D1093_RS04925	COG0612	Peptidase, M16
D1093_RS04960	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D1093_RS04970	COG1194	a g-specific adenine glycosylase
D1093_RS04980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1093_RS04985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1093_RS04985	COG0574	Belongs to the PEP-utilizing enzyme family
D1093_RS05005	COG2166	iron-sulfur cluster assembly
D1093_RS05020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1093_RS05080	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1093_RS05105	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D1093_RS05110	COG1138	Cytochrome C-type biogenesis protein
D1093_RS05115	COG3088	subunit of a heme lyase
D1093_RS05120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1093_RS05125	COG0745	RESPONSE REGULATOR receiver
D1093_RS05130	COG0642	Histidine kinase
D1093_RS05135	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D1093_RS05140	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1093_RS05165	COG0714	Associated with various cellular activities
D1093_RS05170	COG0617	tRNA 3'-terminal CCA addition
D1093_RS05175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1093_RS05190	COG2857	Cytochrome c1
D1093_RS05190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1093_RS05200	COG0012	GTP binding
D1093_RS05205	COG1376	ErfK ybiS ycfS ynhG family protein
D1093_RS05210	COG0193	aminoacyl-tRNA hydrolase activity
D1093_RS05215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1093_RS05230	COG1496	oxidoreductase activity
D1093_RS05240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1093_RS05255	COG2205	protein histidine kinase activity
D1093_RS05260	COG0745	RESPONSE REGULATOR receiver
D1093_RS05265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1093_RS05275	COG0556	nucleotide-excision repair
D1093_RS05285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1093_RS05295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1093_RS05300	COG0492	ferredoxin-NADP+ reductase activity
D1093_RS05305	COG0583	DNA-binding transcription factor activity
D1093_RS05310	COG0436	Aminotransferase
D1093_RS05315	COG1278	Cold shock
D1093_RS05330	COG2205	protein histidine kinase activity
D1093_RS05330	COG2202	Pas domain
D1093_RS05335	COG0308	aminopeptidase N
D1093_RS05345	COG0351	phosphomethylpyrimidine kinase
D1093_RS05355	COG2022	thiamine diphosphate biosynthetic process
D1093_RS05370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1093_RS05380	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D1093_RS05385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1093_RS05390	COG4558	Periplasmic binding protein
D1093_RS05395	COG3720	iron ion transport
D1093_RS05400	COG4771	TonB-dependent receptor
D1093_RS05415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1093_RS05420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1093_RS05425	COG1573	uracil-dna glycosylase
D1093_RS05430	COG1758	RNA polymerase activity
D1093_RS05435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1093_RS05440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1093_RS05450	COG0736	holo-[acyl-carrier-protein] synthase activity
D1093_RS05455	COG0681	Belongs to the peptidase S26 family
D1093_RS05460	COG0571	ribonuclease III activity
D1093_RS05470	COG1381	Involved in DNA repair and RecF pathway recombination
D1093_RS05475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1093_RS05480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1093_RS05485	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D1093_RS05490	COG0354	folic acid binding
D1093_RS05495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1093_RS05510	COG0215	cysteine-tRNA ligase activity
D1093_RS05520	COG5265	(ABC) transporter
D1093_RS05525	COG0688	phosphatidylethanolamine metabolic process
D1093_RS05530	COG1183	phosphatidylcholine synthase activity
D1093_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
D1093_RS05540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1093_RS05555	COG0305	Participates in initiation and elongation during chromosome replication
D1093_RS05560	COG0359	binds to the 23S rRNA
D1093_RS05570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1093_RS05575	COG0360	Binds together with S18 to 16S ribosomal RNA
D1093_RS05585	COG0671	phosphoesterase, PA-phosphatase related
D1093_RS05590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1093_RS05600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1093_RS05605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1093_RS05610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1093_RS05615	COG0194	GDP metabolic process
D1093_RS05620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1093_RS05625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D1093_RS05635	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D1093_RS05665	COG0477	Major facilitator Superfamily
D1093_RS05685	COG0105	UTP biosynthetic process
D1093_RS05690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1093_RS05695	COG0322	excinuclease ABC activity
D1093_RS05700	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1093_RS05705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1093_RS05710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1093_RS05715	COG0805	protein transport
D1093_RS05720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1093_RS05725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1093_RS05730	COG0739	heme binding
D1093_RS05730	COG1388	LysM domain
D1093_RS05735	COG1862	Preprotein translocase
D1093_RS05755	COG0149	triose-phosphate isomerase activity
D1093_RS05760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1093_RS05765	COG0504	CTP synthase activity
D1093_RS05770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D1093_RS05775	COG0148	phosphopyruvate hydratase activity
D1093_RS05785	COG2314	TM2 domain
D1093_RS05790	COG2314	TM2 domain
D1093_RS05800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1093_RS05805	COG0022	dehydrogenase e1 component
D1093_RS05805	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1093_RS05810	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1093_RS05815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1093_RS05820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1093_RS05825	COG2867	negative regulation of translational initiation
D1093_RS05830	COG1058	Belongs to the CinA family
D1093_RS05830	COG1546	Belongs to the CinA family
D1093_RS05835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1093_RS05840	COG1959	2 iron, 2 sulfur cluster binding
D1093_RS05845	COG5000	phosphorelay sensor kinase activity
D1093_RS05850	COG2204	response regulator
D1093_RS05855	COG0569	domain protein
D1093_RS05865	COG0740	serine-type endopeptidase activity
D1093_RS05870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1093_RS05885	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D1093_RS05895	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1093_RS05900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1093_RS05910	COG4765	Protein conserved in bacteria
D1093_RS05920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1093_RS05935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1093_RS05945	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1093_RS05955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1093_RS05960	COG0081	regulation of translation
D1093_RS05965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1093_RS05970	COG0222	ribosome binding
D1093_RS05975	COG0085	RNA polymerase activity
D1093_RS05980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1093_RS05995	COG1760	l-serine dehydratase
D1093_RS06005	COG1686	Belongs to the peptidase S11 family
D1093_RS06010	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D1093_RS06035	COG0052	Belongs to the universal ribosomal protein uS2 family
D1093_RS06040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1093_RS06045	COG0528	UMP kinase activity
D1093_RS06050	COG0233	cytoplasmic translational termination
D1093_RS06060	COG0750	zinc metalloprotease
D1093_RS06065	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1093_RS06070	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1093_RS06075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1093_RS06080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1093_RS06090	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1093_RS06095	COG1126	abc transporter atp-binding protein
D1093_RS06115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1093_RS06120	COG0372	Belongs to the citrate synthase family
D1093_RS06125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1093_RS06130	COG2333	competence protein COMEC
D1093_RS06130	COG0658	competence protein
D1093_RS06135	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1093_RS06150	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1093_RS06160	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D1093_RS06160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1093_RS06220	COG0582	viral genome integration into host DNA
D1093_RS06305	COG0629	single-stranded DNA binding
D1093_RS06465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1093_RS06470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1093_RS06475	COG0649	NAD binding
D1093_RS06480	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D1093_RS06485	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1093_RS06495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1093_RS06500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1093_RS06510	COG0713	ATP synthesis coupled electron transport
D1093_RS06525	COG1007	ATP synthesis coupled electron transport
D1093_RS06540	COG0442	prolyl-tRNA aminoacylation
D1093_RS06550	COG1136	(ABC) transporter
D1093_RS06555	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D1093_RS06560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1093_RS06570	COG1530	ribonuclease E activity
D1093_RS06575	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1093_RS06580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1093_RS06590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1093_RS06595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1093_RS06600	COG2945	thiolester hydrolase activity
D1093_RS06610	COG0719	Fe-S assembly protein
D1093_RS06615	COG0396	ATPase activity
D1093_RS06620	COG0719	Fe-S assembly protein
D1093_RS06625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1093_RS06665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1093_RS06670	COG1183	phosphatidylcholine synthase activity
D1093_RS06675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1093_RS06690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D1093_RS06690	COG0321	lipoyl(octanoyl) transferase activity
D1093_RS06695	COG0084	hydrolase, TatD family'
D1093_RS06710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1093_RS06715	COG1686	Belongs to the peptidase S11 family
D1093_RS06730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1093_RS06735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1093_RS06740	COG0037	tRNA processing
D1093_RS06745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1093_RS06750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1093_RS06755	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1093_RS06760	COG1489	DNA binding
D1093_RS06765	COG0024	Methionine aminopeptidase
D1093_RS06780	COG0596	Alpha beta hydrolase
D1093_RS06790	COG1278	Cold shock
D1093_RS06810	COG0411	ABC transporter
D1093_RS06820	COG0154	amidase activity
D1093_RS06825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1093_RS06830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1093_RS06840	COG0540	Belongs to the ATCase OTCase family
D1093_RS06845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1093_RS06850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1093_RS06855	COG0758	DNA mediated transformation
D1093_RS06865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1093_RS06870	COG0557	exoribonuclease II activity
D1093_RS06880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1093_RS06890	COG1573	uracil-dna glycosylase
D1093_RS06895	COG1522	sequence-specific DNA binding
D1093_RS06900	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1093_RS06905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1093_RS06925	COG0511	ligase activity, forming carbon-carbon bonds
D1093_RS06980	COG0302	gtp cyclohydrolase
D1093_RS06990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1093_RS06995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1093_RS07005	COG0776	regulation of translation
D1093_RS07010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1093_RS07015	COG0416	fatty acid biosynthetic process
D1093_RS07030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1093_RS07035	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1093_RS07045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1093_RS07045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1093_RS07050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1093_RS07055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1093_RS07060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1093_RS07065	COG1612	heme a metabolic process
D1093_RS07075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1093_RS07080	COG1923	regulation of RNA biosynthetic process
D1093_RS07090	COG0281	malic enzyme
D1093_RS07090	COG0280	phosphate acetyltransferase
D1093_RS07095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1093_RS07105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1093_RS07110	COG1063	alcohol dehydrogenase
D1093_RS07120	COG3956	TIGRFAM MazG family protein
D1093_RS07135	COG0071	Belongs to the small heat shock protein (HSP20) family
D1093_RS07215	COG0741	lytic transglycosylase activity
D1093_RS07255	COG3657	addiction module killer protein
D1093_RS07315	COG0582	viral genome integration into host DNA
D1093_RS07330	COG3210	domain, Protein
D1093_RS07360	COG3210	domain, Protein
D1093_RS07360	COG3210	domain, Protein
D1093_RS07415	COG0582	viral genome integration into host DNA
D1093_RS07420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1093_RS07425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1093_RS07445	COG3549	Plasmid maintenance system killer
D1093_RS07475	COG3561	AntA/AntB antirepressor
D1093_RS07485	COG0582	viral genome integration into host DNA
D1093_RS07520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1093_RS07590	COG3657	addiction module killer protein
D1093_RS07615	COG0582	viral genome integration into host DNA
D1093_RS07620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1093_RS07630	COG1196	nuclear chromosome segregation
D1093_RS07630	COG3264	Mechanosensitive ion channel
D1093_RS07645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1093_RS07645	COG4651	solute:proton antiporter activity
D1093_RS07660	COG1253	flavin adenine dinucleotide binding
D1093_RS07675	COG1113	amino acid transport
D1093_RS07680	COG1113	amino acid transport
D1093_RS07685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1093_RS07695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1093_RS07715	COG0028	Belongs to the TPP enzyme family
D1093_RS07720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1093_RS07725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1093_RS07730	COG0330	HflC and HflK could
D1093_RS07745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D1093_RS07750	COG0477	Major facilitator Superfamily
D1093_RS07755	COG0477	Major facilitator Superfamily
D1093_RS07760	COG0477	Major facilitator Superfamily
D1093_RS07790	COG0210	DNA helicase
D1093_RS07800	COG1999	signal sequence binding
D1093_RS07810	COG0006	proline dipeptidase activity
D1093_RS07815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1093_RS07820	COG0497	DNA recombination
D1093_RS07825	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1093_RS07840	COG0849	cell division
D1093_RS07850	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1093_RS07855	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1093_RS07860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1093_RS07865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1093_RS07875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1093_RS07880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1093_RS07905	COG0275	rRNA processing
D1093_RS07930	COG2226	methyltransferase
D1093_RS07945	COG1335	isochorismatase
D1093_RS07990	COG2968	Membrane
D1093_RS08000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1093_RS08010	COG0668	transmembrane transport
D1093_RS08025	COG3161	chorismate lyase activity
D1093_RS08035	COG0505	Belongs to the CarA family
D1093_RS08050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D1093_RS08060	COG0482	sulfurtransferase activity
D1093_RS08155	COG0444	Belongs to the ABC transporter superfamily
D1093_RS08160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1093_RS08165	COG0601	transmembrane transport
D1093_RS08170	COG0747	negative chemotaxis
D1093_RS08180	COG0519	Catalyzes the synthesis of GMP from XMP
D1093_RS08185	COG1570	exodeoxyribonuclease VII activity
D1093_RS08195	COG0747	negative chemotaxis
D1093_RS08215	COG0730	response to heat
D1093_RS08225	COG2086	electron transfer activity
D1093_RS08240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1093_RS08245	COG0792	nuclease activity
D1093_RS08260	COG0489	protein tyrosine kinase activity
D1093_RS08265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1093_RS08270	COG0594	ribonuclease P activity
D1093_RS08280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D1093_RS08290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1093_RS08295	COG0588	phosphoglycerate mutase activity
D1093_RS08340	COG2814	Major facilitator Superfamily
D1093_RS08410	COG0477	Major facilitator Superfamily
D1093_RS08455	COG0735	belongs to the Fur family
D1093_RS08480	COG1054	Belongs to the UPF0176 family
D1093_RS08485	COG0800	Aldolase
D1093_RS08515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1093_RS08515	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1093_RS08520	COG0509	glycine decarboxylation via glycine cleavage system
D1093_RS08525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1093_RS08535	COG2835	tetraacyldisaccharide 4'-kinase activity
D1093_RS08540	COG1396	sequence-specific DNA binding
D1093_RS08545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1093_RS08560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1093_RS08565	COG2011	ABC-type metal ion transport system permease component
D1093_RS08600	COG0523	cobalamin synthesis protein
D1093_RS08610	COG3468	outer membrane autotransporter barrel domain protein
D1093_RS08615	COG3468	outer membrane autotransporter barrel domain protein
D1093_RS08620	COG3468	outer membrane autotransporter barrel domain protein
D1093_RS08645	COG4607	ABC-type enterochelin transport system periplasmic component
D1093_RS08650	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1093_RS08655	COG4605	iron ion homeostasis
D1093_RS08660	COG4604	ABC transporter, ATP-binding protein
D1093_RS08735	COG1475	DNA binding
D1093_RS08765	COG3468	outer membrane autotransporter barrel domain protein
D1093_RS08780	COG3468	outer membrane autotransporter barrel domain protein
D1093_RS08830	COG1192	Involved in chromosome partitioning
D1093_RS08845	COG0196	riboflavin kinase activity
D1093_RS08860	COG1396	sequence-specific DNA binding
D1093_RS08870	COG3838	Conjugal transfer protein Trbc
D1093_RS08875	COG3702	type iv secretory pathway
D1093_RS08880	COG3451	type IV secretory pathway VirB4
D1093_RS08890	COG3704	protein secretion by the type IV secretion system
D1093_RS08900	COG3736	Type IV secretory pathway, component VirB8
D1093_RS08905	COG3504	Conjugal transfer protein
D1093_RS08910	COG2948	multi-organism process
D1093_RS08915	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D1093_RS08925	COG2184	nucleotidyltransferase activity
D1093_RS08930	COG3505	Type IV secretory pathway VirD4
D1093_RS08940	COG2184	nucleotidyltransferase activity
D1093_RS08970	COG0728	peptidoglycan biosynthetic process
D1093_RS08975	COG0180	Tryptophanyl-tRNA synthetase
D1093_RS08985	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D1093_RS08990	COG2824	Alkylphosphonate utilization operon protein PhnA
D1093_RS08995	COG0033	Phosphoglucomutase
D1093_RS09010	COG0124	histidyl-tRNA synthetase
D1093_RS09015	COG1396	sequence-specific DNA binding
D1093_RS09020	COG0284	orotidine-5'-phosphate decarboxylase activity
D1093_RS09080	COG3920	Histidine kinase
D1093_RS09095	COG0784	Response regulator, receiver
D1093_RS09185	COG1396	sequence-specific DNA binding
D1093_RS09205	COG1396	sequence-specific DNA binding
D1093_RS09230	COG1396	sequence-specific DNA binding
D1093_RS09245	COG1396	sequence-specific DNA binding
D1093_RS09285	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D1093_RS09290	COG0424	maF-like protein
D1093_RS09295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1093_RS09320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1093_RS09325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1093_RS09335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1093_RS09340	COG0457	Tetratricopeptide repeat
D1093_RS09360	COG1692	metallophosphoesterase
D1093_RS09365	COG2814	Major facilitator Superfamily
D1093_RS09375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1093_RS09385	COG0473	3-isopropylmalate dehydrogenase activity
D1093_RS09385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1093_RS09405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1093_RS09700	COG4948	Mandelate Racemase Muconate Lactonizing
D1093_RS09710	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1093_RS09720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1093_RS09725	COG0277	FAD linked oxidase domain protein
D1093_RS09735	COG0534	Mate efflux family protein
D1093_RS09755	COG1396	sequence-specific DNA binding
D1093_RS09790	COG3701	Conjugal transfer protein
D1093_RS09855	COG4962	Type ii secretion system protein e
D1093_RS09860	COG3838	Conjugal transfer protein Trbc
D1093_RS09870	COG3451	type IV secretory pathway VirB4
D1093_RS09875	COG5314	conjugation