locus-tag	class	description
BWD162_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BWD162_RS00020	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BWD162_RS00025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BWD162_RS00030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BWD162_RS00035	COG1845	cytochrome c oxidase, subunit III
BWD162_RS00040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BWD162_RS00055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWD162_RS00075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BWD162_RS00080	COG1072	(Pantothenic acid kinase))
BWD162_RS00085	COG0252	asparaginase activity
BWD162_RS00090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BWD162_RS00095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BWD162_RS00100	COG1185	polyribonucleotide nucleotidyltransferase activity
BWD162_RS00105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BWD162_RS00115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BWD162_RS00120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BWD162_RS00125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BWD162_RS00135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BWD162_RS00135	COG0195	Participates in both transcription termination and antitermination
BWD162_RS00140	COG0779	Required for maturation of 30S ribosomal subunits
BWD162_RS00145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BWD162_RS00150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BWD162_RS00155	COG1396	sequence-specific DNA binding
BWD162_RS00160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BWD162_RS00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BWD162_RS00175	COG1702	phosphate starvation-inducible protein PhoH
BWD162_RS00180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWD162_RS00185	COG0456	acetyltransferase
BWD162_RS00190	COG1214	PFAM Peptidase M22, glycoprotease
BWD162_RS00195	COG2855	membrane
BWD162_RS00200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BWD162_RS00205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BWD162_RS00225	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BWD162_RS00230	COG3474	cytochrome
BWD162_RS00235	COG4174	ABC transporter (Permease)
BWD162_RS00240	COG4239	(ABC) transporter, permease
BWD162_RS00255	COG0189	ligase activity
BWD162_RS00260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BWD162_RS00265	COG0573	inorganic phosphate transmembrane transporter activity
BWD162_RS00275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BWD162_RS00280	COG0704	Plays a role in the regulation of phosphate uptake
BWD162_RS00290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BWD162_RS00295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWD162_RS00310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BWD162_RS00315	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BWD162_RS00320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BWD162_RS00330	COG0590	tRNA wobble adenosine to inosine editing
BWD162_RS00340	COG0742	ribosomal rna small subunit methyltransferase
BWD162_RS00345	COG1752	Esterase of the alpha-beta hydrolase superfamily
BWD162_RS00350	COG0312	modulator of DNA gyrase
BWD162_RS00355	COG0483	inositol monophosphate 1-phosphatase activity
BWD162_RS00370	COG1519	Transferase
BWD162_RS00375	COG1663	tetraacyldisaccharide 4'-kinase activity
BWD162_RS00385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BWD162_RS00390	COG0717	Belongs to the dCTP deaminase family
BWD162_RS00395	COG1304	FMN binding
BWD162_RS00465	COG3093	addiction module antidote protein HigA
BWD162_RS00570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BWD162_RS00575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BWD162_RS00585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BWD162_RS00590	COG0564	pseudouridine synthase activity
BWD162_RS00615	COG0167	dihydroorotate dehydrogenase activity
BWD162_RS00630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWD162_RS00635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BWD162_RS00650	COG3572	ergothioneine biosynthetic process
BWD162_RS00655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BWD162_RS00670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BWD162_RS00675	COG0166	Belongs to the GPI family
BWD162_RS00700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BWD162_RS00705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BWD162_RS00770	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BWD162_RS00775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BWD162_RS00780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BWD162_RS00785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BWD162_RS00790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BWD162_RS00795	COG0799	negative regulation of ribosome biogenesis
BWD162_RS00800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BWD162_RS00810	COG0793	Belongs to the peptidase S41A family
BWD162_RS00820	COG5342	invasion associated locus B
BWD162_RS00830	COG1872	DUF167
BWD162_RS00835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BWD162_RS00840	COG1217	gtp-binding protein TYPA
BWD162_RS00845	COG2239	Acts as a magnesium transporter
BWD162_RS00855	COG2951	lytic endotransglycosylase activity
BWD162_RS00860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BWD162_RS00865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BWD162_RS00865	COG0517	IMP dehydrogenase activity
BWD162_RS00885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BWD162_RS00900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWD162_RS00900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BWD162_RS00905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BWD162_RS00905	COG0519	Catalyzes the synthesis of GMP from XMP
BWD162_RS00915	COG3842	ATPase activity
BWD162_RS00920	COG0395	ABC-type sugar transport system, permease component
BWD162_RS00925	COG1175	transmembrane transport
BWD162_RS00935	COG0803	Belongs to the bacterial solute-binding protein 9 family
BWD162_RS00945	COG1121	(ABC) transporter
BWD162_RS00955	COG1780	Probably involved in ribonucleotide reductase function
BWD162_RS00960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWD162_RS00970	COG2890	protein-(glutamine-N5) methyltransferase activity
BWD162_RS00975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BWD162_RS00985	COG0653	protein targeting
BWD162_RS00990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWD162_RS00995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BWD162_RS01000	COG0494	nUDIX hydrolase
BWD162_RS01005	COG1823	symporter activity
BWD162_RS01015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BWD162_RS01020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BWD162_RS01025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWD162_RS01030	COG0527	aspartate kinase activity
BWD162_RS01035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BWD162_RS01045	COG3273	potassium ion transport
BWD162_RS01045	COG0471	metal ion transport
BWD162_RS01055	COG1160	GTP binding
BWD162_RS01065	COG0356	it plays a direct role in the translocation of protons across the membrane
BWD162_RS01070	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWD162_RS01075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BWD162_RS01080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BWD162_RS01085	COG0751	glycine-tRNA ligase activity
BWD162_RS01100	COG0142	geranyltranstransferase activity
BWD162_RS01120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BWD162_RS01125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BWD162_RS01130	COG0009	L-threonylcarbamoyladenylate synthase
BWD162_RS01150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BWD162_RS01155	COG0259	pyridoxamine-phosphate oxidase activity
BWD162_RS01160	COG0484	heat shock protein binding
BWD162_RS01165	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BWD162_RS01170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BWD162_RS01175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BWD162_RS01175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BWD162_RS01180	COG1722	exodeoxyribonuclease VII activity
BWD162_RS01185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BWD162_RS01195	COG0312	modulator of DNA gyrase
BWD162_RS01205	COG0109	protoheme IX farnesyltransferase activity
BWD162_RS01210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BWD162_RS01220	COG0328	RNA-DNA hybrid ribonuclease activity
BWD162_RS01230	COG1678	Uncharacterized ACR, COG1678
BWD162_RS01235	COG1716	ATPase activity
BWD162_RS01235	COG5001	Diguanylate cyclase
BWD162_RS01240	COG0612	Peptidase, M16
BWD162_RS01255	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BWD162_RS01260	COG1194	a g-specific adenine glycosylase
BWD162_RS01270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BWD162_RS01270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BWD162_RS01275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BWD162_RS01275	COG0574	Belongs to the PEP-utilizing enzyme family
BWD162_RS01285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BWD162_RS01300	COG2166	iron-sulfur cluster assembly
BWD162_RS01335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BWD162_RS01340	COG1138	Cytochrome C-type biogenesis protein
BWD162_RS01345	COG3088	subunit of a heme lyase
BWD162_RS01350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWD162_RS01355	COG0745	RESPONSE REGULATOR receiver
BWD162_RS01360	COG2205	protein histidine kinase activity
BWD162_RS01365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BWD162_RS01370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BWD162_RS01370	COG2169	Transcriptional regulator
BWD162_RS01375	COG2205	protein histidine kinase activity
BWD162_RS01375	COG2202	Pas domain
BWD162_RS01380	COG0308	aminopeptidase N
BWD162_RS01390	COG0351	phosphomethylpyrimidine kinase
BWD162_RS01400	COG2022	thiamine diphosphate biosynthetic process
BWD162_RS01415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BWD162_RS01430	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BWD162_RS01440	COG4558	Periplasmic binding protein
BWD162_RS01445	COG3720	iron ion transport
BWD162_RS01450	COG4771	TonB-dependent receptor
BWD162_RS01450	COG1629	transport
BWD162_RS01465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWD162_RS01470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BWD162_RS01475	COG1573	uracil-dna glycosylase
BWD162_RS01480	COG1758	RNA polymerase activity
BWD162_RS01490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BWD162_RS01500	COG0736	holo-[acyl-carrier-protein] synthase activity
BWD162_RS01505	COG0681	Belongs to the peptidase S26 family
BWD162_RS01510	COG0571	ribonuclease III activity
BWD162_RS01520	COG1381	Involved in DNA repair and RecF pathway recombination
BWD162_RS01525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BWD162_RS01530	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BWD162_RS01535	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BWD162_RS01540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BWD162_RS01545	COG0354	folic acid binding
BWD162_RS01550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BWD162_RS01565	COG5265	(ABC) transporter
BWD162_RS01570	COG0688	phosphatidylethanolamine metabolic process
BWD162_RS01575	COG1183	phosphatidylcholine synthase activity
BWD162_RS01580	COG1028	Short-chain dehydrogenase reductase Sdr
BWD162_RS01585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BWD162_RS01600	COG0305	Participates in initiation and elongation during chromosome replication
BWD162_RS01605	COG0359	binds to the 23S rRNA
BWD162_RS01615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BWD162_RS01620	COG0360	Binds together with S18 to 16S ribosomal RNA
BWD162_RS01630	COG0671	phosphoesterase, PA-phosphatase related
BWD162_RS01635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BWD162_RS01645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWD162_RS01650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWD162_RS01655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BWD162_RS01660	COG0194	GDP metabolic process
BWD162_RS01665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BWD162_RS01670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BWD162_RS01675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWD162_RS01705	COG0477	Major facilitator Superfamily
BWD162_RS01725	COG0105	UTP biosynthetic process
BWD162_RS01730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BWD162_RS01735	COG0322	excinuclease ABC activity
BWD162_RS01740	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BWD162_RS01745	COG1472	Belongs to the glycosyl hydrolase 3 family
BWD162_RS01765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BWD162_RS01770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BWD162_RS01775	COG1388	LysM domain
BWD162_RS01775	COG4942	peptidase
BWD162_RS01780	COG1862	Preprotein translocase
BWD162_RS01790	COG1562	ergosterol biosynthetic process
BWD162_RS01800	COG0149	triose-phosphate isomerase activity
BWD162_RS01810	COG0504	CTP synthase activity
BWD162_RS01815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BWD162_RS01820	COG0148	phosphopyruvate hydratase activity
BWD162_RS01825	COG2314	TM2 domain
BWD162_RS01835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BWD162_RS01840	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWD162_RS01840	COG0022	dehydrogenase e1 component
BWD162_RS01845	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWD162_RS01850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWD162_RS01855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BWD162_RS01860	COG2867	negative regulation of translational initiation
BWD162_RS01865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BWD162_RS01865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BWD162_RS01870	COG1959	2 iron, 2 sulfur cluster binding
BWD162_RS01880	COG2204	response regulator
BWD162_RS01885	COG0569	domain protein
BWD162_RS01890	COG0740	serine-type endopeptidase activity
BWD162_RS01895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BWD162_RS01910	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BWD162_RS01920	COG0544	peptidyl-prolyl cis-trans isomerase activity
BWD162_RS01925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWD162_RS01935	COG4765	Protein conserved in bacteria
BWD162_RS01950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BWD162_RS01965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BWD162_RS01975	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BWD162_RS01985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BWD162_RS01990	COG0081	regulation of translation
BWD162_RS01995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BWD162_RS02000	COG0222	ribosome binding
BWD162_RS02005	COG0085	RNA polymerase activity
BWD162_RS02010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BWD162_RS02020	COG1760	l-serine dehydratase
BWD162_RS02030	COG1686	Belongs to the peptidase S11 family
BWD162_RS02060	COG0052	Belongs to the universal ribosomal protein uS2 family
BWD162_RS02065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BWD162_RS02070	COG0528	UMP kinase activity
BWD162_RS02075	COG0233	cytoplasmic translational termination
BWD162_RS02085	COG0750	zinc metalloprotease
BWD162_RS02090	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWD162_RS02095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWD162_RS02100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWD162_RS02115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWD162_RS02120	COG1126	abc transporter atp-binding protein
BWD162_RS02130	COG4215	(ABC) transporter
BWD162_RS02140	COG0372	Belongs to the citrate synthase family
BWD162_RS02145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWD162_RS02160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BWD162_RS02175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BWD162_RS02185	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BWD162_RS02185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWD162_RS02190	COG0513	Belongs to the DEAD box helicase family
BWD162_RS02205	COG2986	histidine ammonia-lyase
BWD162_RS02230	COG0071	Belongs to the small heat shock protein (HSP20) family
BWD162_RS02255	COG1063	alcohol dehydrogenase
BWD162_RS02260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWD162_RS02265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWD162_RS02270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWD162_RS02275	COG0280	phosphate acetyltransferase
BWD162_RS02275	COG0281	malic enzyme
BWD162_RS02285	COG1923	regulation of RNA biosynthetic process
BWD162_RS02290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BWD162_RS02300	COG1612	heme a metabolic process
BWD162_RS02310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BWD162_RS02315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BWD162_RS02320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWD162_RS02320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWD162_RS02330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BWD162_RS02335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWD162_RS02340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWD162_RS02350	COG0416	fatty acid biosynthetic process
BWD162_RS02355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BWD162_RS02360	COG0776	regulation of translation
BWD162_RS02370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BWD162_RS02375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BWD162_RS02385	COG0302	gtp cyclohydrolase
BWD162_RS02420	COG2814	Major facilitator Superfamily
BWD162_RS02430	COG0582	viral genome integration into host DNA
BWD162_RS02630	COG3657	addiction module killer protein
BWD162_RS02645	COG3561	AntA/AntB antirepressor
BWD162_RS02685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BWD162_RS02720	COG3561	AntA/AntB antirepressor
BWD162_RS02745	COG0439	Biotin carboxylase
BWD162_RS02750	COG0511	ligase activity, forming carbon-carbon bonds
BWD162_RS02765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BWD162_RS02775	COG1573	uracil-dna glycosylase
BWD162_RS02785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BWD162_RS02790	COG0557	exoribonuclease II activity
BWD162_RS02795	COG1754	DNA topoisomerase type I activity
BWD162_RS02795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BWD162_RS02805	COG0758	DNA mediated transformation
BWD162_RS02810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BWD162_RS02820	COG0540	Belongs to the ATCase OTCase family
BWD162_RS02830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BWD162_RS02835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWD162_RS02840	COG0154	amidase activity
BWD162_RS02850	COG0411	ABC transporter
BWD162_RS02875	COG1278	Cold shock
BWD162_RS02885	COG0596	Alpha beta hydrolase
BWD162_RS02900	COG0024	Methionine aminopeptidase
BWD162_RS02905	COG1489	DNA binding
BWD162_RS02915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BWD162_RS02920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BWD162_RS02925	COG0037	tRNA processing
BWD162_RS02930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWD162_RS02935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BWD162_RS02950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BWD162_RS02960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWD162_RS02965	COG0084	hydrolase, TatD family'
BWD162_RS02970	COG0321	lipoyl(octanoyl) transferase activity
BWD162_RS02970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BWD162_RS02975	COG0784	Response regulator, receiver
BWD162_RS02980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BWD162_RS02985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BWD162_RS02995	COG0187	DNA topoisomerase II activity
BWD162_RS03000	COG0321	lipoyl(octanoyl) transferase activity
BWD162_RS03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BWD162_RS03100	COG3657	addiction module killer protein
BWD162_RS03105	COG0629	single-stranded DNA binding
BWD162_RS03245	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWD162_RS03250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWD162_RS03255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWD162_RS03260	COG0649	NAD binding
BWD162_RS03265	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BWD162_RS03270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BWD162_RS03280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BWD162_RS03285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWD162_RS03295	COG0713	ATP synthesis coupled electron transport
BWD162_RS03310	COG1007	ATP synthesis coupled electron transport
BWD162_RS03315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BWD162_RS03315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BWD162_RS03325	COG0442	prolyl-tRNA aminoacylation
BWD162_RS03335	COG1136	(ABC) transporter
BWD162_RS03340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BWD162_RS03360	COG1530	ribonuclease E activity
BWD162_RS03365	COG0860	N-Acetylmuramoyl-L-alanine amidase
BWD162_RS03370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BWD162_RS03380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BWD162_RS03385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BWD162_RS03390	COG2945	thiolester hydrolase activity
BWD162_RS03405	COG0396	ATPase activity
BWD162_RS03410	COG0719	Fe-S assembly protein
BWD162_RS03415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BWD162_RS03430	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BWD162_RS03455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWD162_RS03460	COG1183	phosphatidylcholine synthase activity
BWD162_RS03490	COG0628	permease
BWD162_RS03495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BWD162_RS03500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BWD162_RS03520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BWD162_RS03530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BWD162_RS03540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BWD162_RS03545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BWD162_RS03550	COG0047	phosphoribosylformylglycinamidine synthase activity
BWD162_RS03560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BWD162_RS03580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BWD162_RS03585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BWD162_RS03590	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BWD162_RS03600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BWD162_RS03620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BWD162_RS03625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BWD162_RS03630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWD162_RS03635	COG0785	Cytochrome C biogenesis protein
BWD162_RS03650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BWD162_RS03655	COG0018	arginyl-trna synthetase
BWD162_RS03665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BWD162_RS03670	COG1494	fructose-1,6-bisphosphatase
BWD162_RS03685	COG0582	viral genome integration into host DNA
BWD162_RS03740	COG3561	AntA/AntB antirepressor
BWD162_RS03745	COG3561	AntA/AntB antirepressor
BWD162_RS03755	COG1598	PFAM Uncharacterised protein family UPF0150
BWD162_RS03810	COG0538	isocitrate dehydrogenase activity
BWD162_RS03835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BWD162_RS03840	COG0629	single-stranded DNA binding
BWD162_RS03850	COG0347	Belongs to the P(II) protein family
BWD162_RS03855	COG0174	glutamine synthetase
BWD162_RS03875	COG1132	(ABC) transporter
BWD162_RS03880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BWD162_RS03885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BWD162_RS03890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BWD162_RS03900	COG0203	ribosomal protein L17
BWD162_RS03905	COG0202	RNA polymerase activity
BWD162_RS03910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BWD162_RS03915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BWD162_RS03930	COG0200	Binds to the 23S rRNA
BWD162_RS03935	COG1841	ribosomal large subunit assembly
BWD162_RS03940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BWD162_RS03945	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BWD162_RS03950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BWD162_RS03955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BWD162_RS03960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BWD162_RS03965	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BWD162_RS03970	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BWD162_RS03975	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BWD162_RS03980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BWD162_RS03985	COG0255	Belongs to the universal ribosomal protein uL29 family
BWD162_RS03990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BWD162_RS03995	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BWD162_RS04005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BWD162_RS04010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BWD162_RS04015	COG0089	rRNA binding
BWD162_RS04020	COG0088	Forms part of the polypeptide exit tunnel
BWD162_RS04025	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BWD162_RS04035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BWD162_RS04040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BWD162_RS04045	COG0049	tRNA binding
BWD162_RS04050	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BWD162_RS04055	COG0708	Exodeoxyribonuclease III
BWD162_RS04065	COG0765	amino acid transport
BWD162_RS04070	COG0765	amino acid transport
BWD162_RS04075	COG1126	abc transporter atp-binding protein
BWD162_RS04080	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BWD162_RS04085	COG0525	valine-tRNA ligase activity
BWD162_RS04100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BWD162_RS04120	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BWD162_RS04135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BWD162_RS04150	COG3264	Mechanosensitive ion channel
BWD162_RS04150	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BWD162_RS04230	COG3657	addiction module killer protein
BWD162_RS04240	COG1113	amino acid transport
BWD162_RS04255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BWD162_RS04260	COG0028	Belongs to the TPP enzyme family
BWD162_RS04265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BWD162_RS04270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWD162_RS04290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BWD162_RS04295	COG0477	Major facilitator Superfamily
BWD162_RS04320	COG1999	signal sequence binding
BWD162_RS04330	COG0006	proline dipeptidase activity
BWD162_RS04335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BWD162_RS04340	COG0497	DNA recombination
BWD162_RS04345	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWD162_RS04360	COG0849	cell division
BWD162_RS04370	COG1181	Belongs to the D-alanine--D-alanine ligase family
BWD162_RS04375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BWD162_RS04380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWD162_RS04385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BWD162_RS04395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BWD162_RS04400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BWD162_RS04425	COG0275	rRNA processing
BWD162_RS04445	COG1335	isochorismatase
BWD162_RS04475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BWD162_RS04485	COG0668	transmembrane transport
BWD162_RS04495	COG3161	chorismate lyase activity
BWD162_RS04500	COG0505	Belongs to the CarA family
BWD162_RS04515	COG1278	Cold shock
BWD162_RS04520	COG0436	Aminotransferase
BWD162_RS04525	COG0583	DNA-binding transcription factor activity
BWD162_RS04530	COG0492	ferredoxin-NADP+ reductase activity
BWD162_RS04535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BWD162_RS04545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BWD162_RS04555	COG0556	nucleotide-excision repair
BWD162_RS04565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWD162_RS04570	COG0745	RESPONSE REGULATOR receiver
BWD162_RS04575	COG2205	protein histidine kinase activity
BWD162_RS04590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BWD162_RS04605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BWD162_RS04610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BWD162_RS04615	COG0193	aminoacyl-tRNA hydrolase activity
BWD162_RS04620	COG1376	ErfK ybiS ycfS ynhG family protein
BWD162_RS04625	COG0012	GTP binding
BWD162_RS04635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BWD162_RS04640	COG0617	tRNA 3'-terminal CCA addition
BWD162_RS04645	COG0714	Associated with various cellular activities
BWD162_RS04685	COG0482	sulfurtransferase activity
BWD162_RS04740	COG0444	Belongs to the ABC transporter superfamily
BWD162_RS04750	COG0601	transmembrane transport
BWD162_RS04755	COG0747	negative chemotaxis
BWD162_RS04760	COG0747	negative chemotaxis
BWD162_RS04765	COG0519	Catalyzes the synthesis of GMP from XMP
BWD162_RS04770	COG1570	exodeoxyribonuclease VII activity
BWD162_RS04810	COG0792	nuclease activity
BWD162_RS04815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BWD162_RS04825	COG0489	protein tyrosine kinase activity
BWD162_RS04840	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BWD162_RS04845	COG0594	ribonuclease P activity
BWD162_RS04855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BWD162_RS04865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BWD162_RS04870	COG0588	phosphoglycerate mutase activity
BWD162_RS04895	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BWD162_RS04955	COG1054	Belongs to the UPF0176 family
BWD162_RS04970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWD162_RS04970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWD162_RS04975	COG0509	glycine decarboxylation via glycine cleavage system
BWD162_RS04980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BWD162_RS04985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWD162_RS04990	COG2835	tetraacyldisaccharide 4'-kinase activity
BWD162_RS04995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BWD162_RS05005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BWD162_RS05010	COG2011	ABC-type metal ion transport system permease component
BWD162_RS05030	COG3023	N-Acetylmuramoyl-L-alanine amidase
BWD162_RS05050	COG3561	AntA/AntB antirepressor
BWD162_RS05065	COG3657	addiction module killer protein
BWD162_RS05215	COG1113	amino acid transport
BWD162_RS05220	COG1122	ATPase activity
BWD162_RS05230	COG1268	BioY protein
BWD162_RS05240	COG4607	ABC-type enterochelin transport system periplasmic component
BWD162_RS05245	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWD162_RS05250	COG4605	iron ion homeostasis
BWD162_RS05255	COG4604	ABC transporter, ATP-binding protein
BWD162_RS05265	COG0582	viral genome integration into host DNA
BWD162_RS05285	COG3561	AntA/AntB antirepressor
BWD162_RS05300	COG1396	sequence-specific DNA binding
BWD162_RS05370	COG3561	AntA/AntB antirepressor
BWD162_RS05375	COG3561	AntA/AntB antirepressor
BWD162_RS05385	COG0124	histidyl-tRNA synthetase
BWD162_RS05415	COG1598	PFAM Uncharacterised protein family UPF0150
BWD162_RS05510	COG3041	Addiction module toxin RelE StbE family
BWD162_RS05515	COG3077	Addiction module antitoxin, RelB DinJ family
BWD162_RS05570	COG4680	protein conserved in bacteria
BWD162_RS05665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BWD162_RS05715	COG1360	Flagellar Motor Protein
BWD162_RS05750	COG1338	Plays a role in the flagellum-specific transport system
BWD162_RS05760	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BWD162_RS05770	COG1706	bacterial-type flagellum-dependent cell motility
BWD162_RS05775	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
BWD162_RS05780	COG4786	Flagellar basal body rod
BWD162_RS05790	COG1558	bacterial-type flagellum-dependent cell motility
BWD162_RS05795	COG1815	bacterial-type flagellum-dependent cell motility
BWD162_RS05800	COG1157	protein secretion by the type III secretion system
BWD162_RS05805	COG4786	Flagellar basal body rod
BWD162_RS05815	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BWD162_RS05820	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BWD162_RS05830	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BWD162_RS05835	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BWD162_RS05840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BWD162_RS05870	COG1684	flagellar biosynthetic protein fliR
BWD162_RS05885	COG0196	riboflavin kinase activity
BWD162_RS05955	COG1396	sequence-specific DNA binding
BWD162_RS05995	COG0180	Tryptophanyl-tRNA synthetase
BWD162_RS06000	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BWD162_RS06005	COG0459	protein refolding
BWD162_RS06010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BWD162_RS06020	COG0033	Phosphoglucomutase
BWD162_RS06030	COG0124	histidyl-tRNA synthetase
BWD162_RS06035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BWD162_RS06080	COG3920	Histidine kinase
BWD162_RS06100	COG0784	Response regulator, receiver
BWD162_RS06215	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BWD162_RS06225	COG0424	maF-like protein
BWD162_RS06230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BWD162_RS06240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BWD162_RS06245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BWD162_RS06250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BWD162_RS06270	COG1692	metallophosphoesterase
BWD162_RS06280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BWD162_RS06335	COG1238	metal cluster binding
BWD162_RS06350	COG0756	dUTP diphosphatase activity
BWD162_RS06355	COG0848	biopolymer transport protein
BWD162_RS06380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BWD162_RS06385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWD162_RS06390	COG0037	tRNA processing
BWD162_RS06405	COG2885	chlorophyll binding
BWD162_RS06420	COG0217	transcriptional regulatory protein
BWD162_RS06425	COG0254	rRNA binding
BWD162_RS06430	COG1132	(ABC) transporter
BWD162_RS06435	COG0483	inositol monophosphate 1-phosphatase activity
BWD162_RS06440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BWD162_RS06470	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BWD162_RS06475	COG0632	four-way junction helicase activity
BWD162_RS06480	COG2255	four-way junction helicase activity
BWD162_RS06485	COG0824	Thioesterase
BWD162_RS06505	COG0823	Involved in the tonB-independent uptake of proteins
BWD162_RS06510	COG3588	fructose-bisphosphate aldolase
BWD162_RS06515	COG0126	phosphoglycerate kinase activity
BWD162_RS06550	COG3750	Belongs to the UPF0335 family
BWD162_RS06555	COG0488	(ABC) transporter
BWD162_RS06575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BWD162_RS06585	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BWD162_RS06595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BWD162_RS06600	COG0142	geranyltranstransferase activity
BWD162_RS06605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BWD162_RS06630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BWD162_RS06640	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BWD162_RS06645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BWD162_RS06650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWD162_RS06670	COG0495	leucyl-tRNA aminoacylation
BWD162_RS06675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BWD162_RS06680	COG2884	Cell division ATP-binding protein ftsE
BWD162_RS06695	COG1136	(ABC) transporter
BWD162_RS06695	COG0577	efflux transmembrane transporter activity
BWD162_RS06700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWD162_RS06720	COG1674	ftsk spoiiie
BWD162_RS06725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWD162_RS06750	COG0335	large ribosomal subunit rRNA binding
BWD162_RS06755	COG0336	Belongs to the RNA methyltransferase TrmD family
BWD162_RS06760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BWD162_RS06800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BWD162_RS06815	COG0138	bifunctional purine biosynthesis protein purh
BWD162_RS06830	COG0501	Belongs to the peptidase M48B family
BWD162_RS06840	COG0228	four-way junction DNA binding
BWD162_RS06850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BWD162_RS06855	COG0288	reversible hydration of carbon dioxide
BWD162_RS06885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BWD162_RS06900	COG0745	RESPONSE REGULATOR receiver
BWD162_RS06915	COG0019	diaminopimelate decarboxylase activity
BWD162_RS06930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWD162_RS06960	COG1686	Belongs to the peptidase S11 family
BWD162_RS06965	COG3034	peptidoglycan biosynthetic process
BWD162_RS06970	COG0825	malonyl-CoA metabolic process
BWD162_RS06995	COG3895	Periplasmic Protein
BWD162_RS07000	COG1320	monovalent cation:proton antiporter activity
BWD162_RS07005	COG2212	antiporter activity
BWD162_RS07010	COG1863	multisubunit Na H antiporter MnhE subunit
BWD162_RS07015	COG0651	ATP synthesis coupled electron transport
BWD162_RS07020	COG1006	Multisubunit Na H antiporter MnhC subunit
BWD162_RS07030	COG0019	diaminopimelate decarboxylase activity
BWD162_RS07045	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWD162_RS07050	COG0567	Dehydrogenase, E1 component
BWD162_RS07060	COG0045	succinate-CoA ligase (ADP-forming) activity
BWD162_RS07065	COG0039	L-malate dehydrogenase activity
BWD162_RS07070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BWD162_RS07080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BWD162_RS07085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWD162_RS07090	COG0552	protein localization to endoplasmic reticulum
BWD162_RS07095	COG2917	probably involved in intracellular septation
BWD162_RS07115	COG0357	Ribosomal RNA small subunit methyltransferase G
BWD162_RS07120	COG0445	tRNA wobble uridine modification
BWD162_RS07125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BWD162_RS07130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BWD162_RS07135	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BWD162_RS07140	COG0424	maF-like protein
BWD162_RS07145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BWD162_RS07150	COG0237	dephospho-CoA kinase activity
BWD162_RS07160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BWD162_RS07160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BWD162_RS07170	COG0670	Belongs to the BI1 family
BWD162_RS07175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BWD162_RS07185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BWD162_RS07185	COG0116	Belongs to the methyltransferase superfamily
BWD162_RS07195	COG0776	regulation of translation
BWD162_RS07210	COG1137	ATPase activity
BWD162_RS07215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWD162_RS07225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BWD162_RS07245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BWD162_RS07265	COG0802	atpase or kinase
BWD162_RS07275	COG0702	epimerase
BWD162_RS07280	COG0285	dihydrofolate synthase activity
BWD162_RS07285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BWD162_RS07295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BWD162_RS07300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BWD162_RS07305	COG2226	methyltransferase
BWD162_RS07320	COG0729	surface antigen
BWD162_RS07330	COG1132	(ABC) transporter
BWD162_RS07335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BWD162_RS07350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWD162_RS07355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BWD162_RS07360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BWD162_RS07365	COG1420	regulation of RNA biosynthetic process
BWD162_RS07370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BWD162_RS07375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BWD162_RS07380	COG2205	protein histidine kinase activity
BWD162_RS07385	COG0745	RESPONSE REGULATOR receiver
BWD162_RS07400	COG0443	Heat shock 70 kDa protein
BWD162_RS07405	COG0484	heat shock protein binding
BWD162_RS07410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BWD162_RS07420	COG0481	GTPase activity
BWD162_RS07425	COG2171	N-acyltransferase activity
BWD162_RS07435	COG0101	tRNA pseudouridine synthase activity
BWD162_RS07440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWD162_RS07445	COG0242	peptide deformylase activity
BWD162_RS07470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BWD162_RS07475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BWD162_RS07480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BWD162_RS07485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWD162_RS07485	COG0072	phenylalanine-tRNA ligase activity
BWD162_RS07495	COG1121	(ABC) transporter
BWD162_RS07500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWD162_RS07505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWD162_RS07510	COG2832	Protein of unknown function (DUF454)
BWD162_RS07515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BWD162_RS07520	COG3459	Glycosyltransferase 36 associated
BWD162_RS07525	COG0539	negative regulation of cytoplasmic translation
BWD162_RS07535	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BWD162_RS07550	COG0129	dihydroxy-acid dehydratase activity
BWD162_RS07555	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BWD162_RS07560	COG0280	phosphate acetyltransferase
BWD162_RS07560	COG0281	malic enzyme
BWD162_RS07565	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BWD162_RS07570	COG3030	protein affecting phage T7 exclusion by the F plasmid
BWD162_RS07595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BWD162_RS07605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWD162_RS07615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BWD162_RS07620	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BWD162_RS07625	COG4133	protoheme IX ABC transporter activity
BWD162_RS07630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BWD162_RS07635	COG0268	Binds directly to 16S ribosomal RNA