locus-tag	class	description
BVWIN_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BVWIN_RS00010	COG0424	maF-like protein
BVWIN_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BVWIN_RS00020	COG0237	dephospho-CoA kinase activity
BVWIN_RS00030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BVWIN_RS00030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BVWIN_RS00040	COG0670	Belongs to the BI1 family
BVWIN_RS00045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BVWIN_RS00055	COG0116	Belongs to the methyltransferase superfamily
BVWIN_RS00055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BVWIN_RS00065	COG0776	regulation of translation
BVWIN_RS00080	COG1137	ATPase activity
BVWIN_RS00085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BVWIN_RS00095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BVWIN_RS00115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BVWIN_RS00130	COG2887	Belongs to the helicase family. UvrD subfamily
BVWIN_RS00135	COG0802	atpase or kinase
BVWIN_RS00140	COG2205	protein histidine kinase activity
BVWIN_RS00145	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BVWIN_RS00155	COG0285	dihydrofolate synthase activity
BVWIN_RS00160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BVWIN_RS00170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BVWIN_RS00175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BVWIN_RS00180	COG2226	methyltransferase
BVWIN_RS00195	COG0606	chelatase, subunit chli
BVWIN_RS00200	COG0729	surface antigen
BVWIN_RS00210	COG1132	(ABC) transporter
BVWIN_RS00215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BVWIN_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BVWIN_RS00235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BVWIN_RS00240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BVWIN_RS00245	COG1420	regulation of RNA biosynthetic process
BVWIN_RS00250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BVWIN_RS00265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BVWIN_RS00275	COG2205	protein histidine kinase activity
BVWIN_RS00280	COG0745	RESPONSE REGULATOR receiver
BVWIN_RS00295	COG0443	Heat shock 70 kDa protein
BVWIN_RS00300	COG0484	heat shock protein binding
BVWIN_RS00310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BVWIN_RS00315	COG0697	spore germination
BVWIN_RS00320	COG0481	GTPase activity
BVWIN_RS00325	COG2171	N-acyltransferase activity
BVWIN_RS00335	COG0101	tRNA pseudouridine synthase activity
BVWIN_RS00340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BVWIN_RS00345	COG0242	peptide deformylase activity
BVWIN_RS00375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BVWIN_RS00380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BVWIN_RS00385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BVWIN_RS00390	COG0072	phenylalanine-tRNA ligase activity
BVWIN_RS00390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BVWIN_RS00400	COG1121	(ABC) transporter
BVWIN_RS00405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BVWIN_RS00410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BVWIN_RS00420	COG2832	Protein of unknown function (DUF454)
BVWIN_RS00425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BVWIN_RS00435	COG0539	negative regulation of cytoplasmic translation
BVWIN_RS00440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BVWIN_RS00445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BVWIN_RS00460	COG0129	dihydroxy-acid dehydratase activity
BVWIN_RS00465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BVWIN_RS00470	COG0281	malic enzyme
BVWIN_RS00470	COG0280	phosphate acetyltransferase
BVWIN_RS00475	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BVWIN_RS00495	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BVWIN_RS00500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BVWIN_RS00510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BVWIN_RS00520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BVWIN_RS00525	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BVWIN_RS00530	COG4133	protoheme IX ABC transporter activity
BVWIN_RS00535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BVWIN_RS00540	COG0268	Binds directly to 16S ribosomal RNA
BVWIN_RS00545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BVWIN_RS00560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BVWIN_RS00565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BVWIN_RS00570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BVWIN_RS00575	COG1845	cytochrome c oxidase, subunit III
BVWIN_RS00580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BVWIN_RS00585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BVWIN_RS00590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BVWIN_RS00600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BVWIN_RS00615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BVWIN_RS00620	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BVWIN_RS00635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BVWIN_RS00640	COG0166	Belongs to the GPI family
BVWIN_RS00650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BVWIN_RS00655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BVWIN_RS00715	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BVWIN_RS00720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BVWIN_RS00725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BVWIN_RS00730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BVWIN_RS00735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BVWIN_RS00740	COG0799	negative regulation of ribosome biogenesis
BVWIN_RS00745	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BVWIN_RS00755	COG0793	Belongs to the peptidase S41A family
BVWIN_RS00760	COG0494	nUDIX hydrolase
BVWIN_RS00765	COG5342	invasion associated locus B
BVWIN_RS00775	COG1872	DUF167
BVWIN_RS00780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BVWIN_RS00785	COG1217	gtp-binding protein TYPA
BVWIN_RS00790	COG2239	Acts as a magnesium transporter
BVWIN_RS00795	COG0339	signal peptide processing
BVWIN_RS00805	COG2951	lytic endotransglycosylase activity
BVWIN_RS00815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BVWIN_RS00815	COG0517	IMP dehydrogenase activity
BVWIN_RS00825	COG2204	response regulator
BVWIN_RS00830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BVWIN_RS00840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BVWIN_RS00840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BVWIN_RS00845	COG0519	Catalyzes the synthesis of GMP from XMP
BVWIN_RS00845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BVWIN_RS00850	COG0584	glycerophosphoryl diester phosphodiesterase
BVWIN_RS00860	COG3842	ATPase activity
BVWIN_RS00865	COG0395	ABC-type sugar transport system, permease component
BVWIN_RS00870	COG1175	transmembrane transport
BVWIN_RS00890	COG1121	(ABC) transporter
BVWIN_RS00895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BVWIN_RS00900	COG1780	Probably involved in ribonucleotide reductase function
BVWIN_RS00905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BVWIN_RS00915	COG2890	protein-(glutamine-N5) methyltransferase activity
BVWIN_RS00920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BVWIN_RS00930	COG0653	protein targeting
BVWIN_RS00935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BVWIN_RS00940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BVWIN_RS00945	COG0494	nUDIX hydrolase
BVWIN_RS00955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BVWIN_RS00960	COG1072	(Pantothenic acid kinase))
BVWIN_RS00965	COG0252	asparaginase activity
BVWIN_RS00970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BVWIN_RS00975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BVWIN_RS00980	COG2813	Specifically methylates the guanine in position
BVWIN_RS00985	COG1185	polyribonucleotide nucleotidyltransferase activity
BVWIN_RS00990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BVWIN_RS01000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BVWIN_RS01005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BVWIN_RS01010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BVWIN_RS01020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BVWIN_RS01020	COG0195	Participates in both transcription termination and antitermination
BVWIN_RS01025	COG0779	Required for maturation of 30S ribosomal subunits
BVWIN_RS01030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BVWIN_RS01035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BVWIN_RS01040	COG1396	sequence-specific DNA binding
BVWIN_RS01055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BVWIN_RS01060	COG1702	phosphate starvation-inducible protein PhoH
BVWIN_RS01065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BVWIN_RS01075	COG1214	PFAM Peptidase M22, glycoprotease
BVWIN_RS01080	COG2855	membrane
BVWIN_RS01085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BVWIN_RS01090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BVWIN_RS01095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BVWIN_RS01105	COG1605	Chorismate mutase
BVWIN_RS01105	COG0077	Prephenate dehydratase
BVWIN_RS01110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BVWIN_RS01115	COG3474	cytochrome
BVWIN_RS01135	COG0189	ligase activity
BVWIN_RS01145	COG0573	inorganic phosphate transmembrane transporter activity
BVWIN_RS01155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BVWIN_RS01160	COG0704	Plays a role in the regulation of phosphate uptake
BVWIN_RS01175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BVWIN_RS01195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BVWIN_RS01200	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BVWIN_RS01205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BVWIN_RS01210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BVWIN_RS01215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BVWIN_RS01225	COG0590	tRNA wobble adenosine to inosine editing
BVWIN_RS01235	COG0742	ribosomal rna small subunit methyltransferase
BVWIN_RS01250	COG1304	FMN binding
BVWIN_RS01255	COG0717	Belongs to the dCTP deaminase family
BVWIN_RS01260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BVWIN_RS01270	COG1663	tetraacyldisaccharide 4'-kinase activity
BVWIN_RS01275	COG1519	Transferase
BVWIN_RS01285	COG0483	inositol monophosphate 1-phosphatase activity
BVWIN_RS01290	COG0312	modulator of DNA gyrase
BVWIN_RS01330	COG4962	Type ii secretion system protein e
BVWIN_RS01335	COG3838	Conjugal transfer protein Trbc
BVWIN_RS01400	COG0305	Participates in initiation and elongation during chromosome replication
BVWIN_RS01415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BVWIN_RS01420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BVWIN_RS01430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BVWIN_RS01435	COG0564	pseudouridine synthase activity
BVWIN_RS01455	COG1970	mechanosensitive ion channel activity
BVWIN_RS01460	COG0167	dihydroorotate dehydrogenase activity
BVWIN_RS01470	COG0174	glutamine synthetase
BVWIN_RS01475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BVWIN_RS01480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BVWIN_RS01485	COG0363	glucosamine-6-phosphate deaminase activity
BVWIN_RS01495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BVWIN_RS01515	COG1823	symporter activity
BVWIN_RS01520	COG2226	methyltransferase
BVWIN_RS01525	COG1040	competence protein
BVWIN_RS01530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BVWIN_RS01535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BVWIN_RS01540	COG0527	aspartate kinase activity
BVWIN_RS01545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BVWIN_RS01555	COG3273	potassium ion transport
BVWIN_RS01555	COG0471	metal ion transport
BVWIN_RS01570	COG1160	GTP binding
BVWIN_RS01580	COG0356	it plays a direct role in the translocation of protons across the membrane
BVWIN_RS01585	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BVWIN_RS01590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BVWIN_RS01595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BVWIN_RS01600	COG0751	glycine-tRNA ligase activity
BVWIN_RS01615	COG0142	geranyltranstransferase activity
BVWIN_RS01635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BVWIN_RS01640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BVWIN_RS01645	COG0009	L-threonylcarbamoyladenylate synthase
BVWIN_RS01650	COG0277	FAD linked oxidase domain protein
BVWIN_RS01665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BVWIN_RS01670	COG0259	pyridoxamine-phosphate oxidase activity
BVWIN_RS01680	COG0484	heat shock protein binding
BVWIN_RS01685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BVWIN_RS01690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BVWIN_RS01695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BVWIN_RS01695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BVWIN_RS01700	COG1722	exodeoxyribonuclease VII activity
BVWIN_RS01705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BVWIN_RS01720	COG0312	modulator of DNA gyrase
BVWIN_RS01730	COG0109	protoheme IX farnesyltransferase activity
BVWIN_RS01735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BVWIN_RS01740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BVWIN_RS01745	COG0328	RNA-DNA hybrid ribonuclease activity
BVWIN_RS01755	COG1678	Uncharacterized ACR, COG1678
BVWIN_RS01765	COG0612	Peptidase, M16
BVWIN_RS01800	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BVWIN_RS01805	COG1194	a g-specific adenine glycosylase
BVWIN_RS01815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BVWIN_RS01815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BVWIN_RS01820	COG0574	Belongs to the PEP-utilizing enzyme family
BVWIN_RS01820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BVWIN_RS01840	COG2166	iron-sulfur cluster assembly
BVWIN_RS01855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BVWIN_RS01890	COG1760	l-serine dehydratase
BVWIN_RS01905	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BVWIN_RS01930	COG0052	Belongs to the universal ribosomal protein uS2 family
BVWIN_RS01935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BVWIN_RS01940	COG0528	UMP kinase activity
BVWIN_RS01945	COG0233	cytoplasmic translational termination
BVWIN_RS01955	COG0750	zinc metalloprotease
BVWIN_RS01965	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BVWIN_RS01970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BVWIN_RS01975	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BVWIN_RS01980	COG3494	Protein of unknown function (DUF1009)
BVWIN_RS01985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BVWIN_RS01990	COG1126	abc transporter atp-binding protein
BVWIN_RS02000	COG4215	(ABC) transporter
BVWIN_RS02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BVWIN_RS02015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BVWIN_RS02020	COG0372	Belongs to the citrate synthase family
BVWIN_RS02025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BVWIN_RS02030	COG0658	competence protein
BVWIN_RS02030	COG2333	competence protein COMEC
BVWIN_RS02035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BVWIN_RS02050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BVWIN_RS02060	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BVWIN_RS02060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BVWIN_RS02080	COG2986	histidine ammonia-lyase
BVWIN_RS02110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BVWIN_RS02135	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BVWIN_RS02140	COG1138	Cytochrome C-type biogenesis protein
BVWIN_RS02150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BVWIN_RS02155	COG0745	RESPONSE REGULATOR receiver
BVWIN_RS02160	COG0642	Histidine kinase
BVWIN_RS02165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BVWIN_RS02170	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BVWIN_RS02180	COG2202	Pas domain
BVWIN_RS02180	COG2205	protein histidine kinase activity
BVWIN_RS02185	COG0308	aminopeptidase N
BVWIN_RS02190	COG1573	uracil-dna glycosylase
BVWIN_RS02195	COG0351	phosphomethylpyrimidine kinase
BVWIN_RS02205	COG2022	thiamine diphosphate biosynthetic process
BVWIN_RS02220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BVWIN_RS02230	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BVWIN_RS02235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BVWIN_RS02240	COG4558	Periplasmic binding protein
BVWIN_RS02245	COG3720	iron ion transport
BVWIN_RS02260	COG0741	lytic transglycosylase activity
BVWIN_RS02265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BVWIN_RS02270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BVWIN_RS02275	COG1573	uracil-dna glycosylase
BVWIN_RS02280	COG1758	RNA polymerase activity
BVWIN_RS02290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BVWIN_RS02300	COG0736	holo-[acyl-carrier-protein] synthase activity
BVWIN_RS02305	COG0681	Belongs to the peptidase S26 family
BVWIN_RS02310	COG0571	ribonuclease III activity
BVWIN_RS02320	COG1381	Involved in DNA repair and RecF pathway recombination
BVWIN_RS02325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BVWIN_RS02330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BVWIN_RS02335	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BVWIN_RS02340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BVWIN_RS02345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BVWIN_RS02355	COG0215	cysteine-tRNA ligase activity
BVWIN_RS02365	COG5265	(ABC) transporter
BVWIN_RS02370	COG0688	phosphatidylethanolamine metabolic process
BVWIN_RS02375	COG1183	phosphatidylcholine synthase activity
BVWIN_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
BVWIN_RS02385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BVWIN_RS02400	COG0305	Participates in initiation and elongation during chromosome replication
BVWIN_RS02405	COG0359	binds to the 23S rRNA
BVWIN_RS02415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BVWIN_RS02420	COG0360	Binds together with S18 to 16S ribosomal RNA
BVWIN_RS02430	COG0671	phosphoesterase, PA-phosphatase related
BVWIN_RS02435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BVWIN_RS02445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BVWIN_RS02450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BVWIN_RS02455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BVWIN_RS02460	COG0194	GDP metabolic process
BVWIN_RS02465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BVWIN_RS02470	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BVWIN_RS02480	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BVWIN_RS02510	COG0477	Major facilitator Superfamily
BVWIN_RS02540	COG0105	UTP biosynthetic process
BVWIN_RS02545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BVWIN_RS02550	COG0322	excinuclease ABC activity
BVWIN_RS02555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BVWIN_RS02560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BVWIN_RS02575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BVWIN_RS02580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BVWIN_RS02585	COG4942	peptidase
BVWIN_RS02585	COG1388	LysM domain
BVWIN_RS02590	COG1862	Preprotein translocase
BVWIN_RS02600	COG1562	ergosterol biosynthetic process
BVWIN_RS02605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BVWIN_RS02610	COG0149	triose-phosphate isomerase activity
BVWIN_RS02620	COG0504	CTP synthase activity
BVWIN_RS02625	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BVWIN_RS02630	COG0148	phosphopyruvate hydratase activity
BVWIN_RS02650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BVWIN_RS02655	COG0508	dehydrogenase complex catalyzes the overall conversion of
BVWIN_RS02655	COG0022	dehydrogenase e1 component
BVWIN_RS02660	COG0508	dehydrogenase complex catalyzes the overall conversion of
BVWIN_RS02665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BVWIN_RS02670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BVWIN_RS02675	COG2867	negative regulation of translational initiation
BVWIN_RS02680	COG1546	Belongs to the CinA family
BVWIN_RS02680	COG1058	Belongs to the CinA family
BVWIN_RS02685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BVWIN_RS02685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BVWIN_RS02690	COG1959	2 iron, 2 sulfur cluster binding
BVWIN_RS02695	COG5000	phosphorelay sensor kinase activity
BVWIN_RS02700	COG2204	response regulator
BVWIN_RS02705	COG0569	domain protein
BVWIN_RS02715	COG0740	serine-type endopeptidase activity
BVWIN_RS02720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BVWIN_RS02735	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BVWIN_RS02745	COG0544	peptidyl-prolyl cis-trans isomerase activity
BVWIN_RS02750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BVWIN_RS02760	COG4765	Protein conserved in bacteria
BVWIN_RS02770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BVWIN_RS02785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BVWIN_RS02795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BVWIN_RS02805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BVWIN_RS02810	COG0081	regulation of translation
BVWIN_RS02815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BVWIN_RS02820	COG0222	ribosome binding
BVWIN_RS02825	COG0085	RNA polymerase activity
BVWIN_RS02830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BVWIN_RS02885	COG0305	Participates in initiation and elongation during chromosome replication
BVWIN_RS02895	COG2900	Belongs to the SlyX family
BVWIN_RS02905	COG1113	amino acid transport
BVWIN_RS02910	COG1122	ATPase activity
BVWIN_RS02920	COG1268	BioY protein
BVWIN_RS02945	COG1253	flavin adenine dinucleotide binding
BVWIN_RS02955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BVWIN_RS02955	COG4651	solute:proton antiporter activity
BVWIN_RS02970	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BVWIN_RS02970	COG3264	Mechanosensitive ion channel
BVWIN_RS02990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BVWIN_RS03035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BVWIN_RS03095	COG3505	Type IV secretory pathway VirD4
BVWIN_RS03125	COG3451	type IV secretory pathway VirB4
BVWIN_RS03130	COG3702	type iv secretory pathway
BVWIN_RS03135	COG3838	Conjugal transfer protein Trbc
BVWIN_RS03145	COG3550	peptidyl-serine autophosphorylation
BVWIN_RS03235	COG0477	Major facilitator Superfamily
BVWIN_RS03240	COG0477	Major facilitator Superfamily
BVWIN_RS03245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BVWIN_RS03260	COG0330	HflC and HflK could
BVWIN_RS03265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BVWIN_RS03270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BVWIN_RS03275	COG0028	Belongs to the TPP enzyme family
BVWIN_RS03300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BVWIN_RS03315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BVWIN_RS03320	COG1113	amino acid transport
BVWIN_RS03355	COG0784	Response regulator, receiver
BVWIN_RS03360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BVWIN_RS03365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BVWIN_RS03375	COG0187	DNA topoisomerase II activity
BVWIN_RS03380	COG0321	lipoyl(octanoyl) transferase activity
BVWIN_RS03385	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BVWIN_RS03405	COG3077	Addiction module antitoxin, RelB DinJ family
BVWIN_RS03465	COG1598	PFAM Uncharacterised protein family UPF0150
BVWIN_RS03475	COG0629	single-stranded DNA binding
BVWIN_RS03485	COG0629	single-stranded DNA binding
BVWIN_RS03495	COG1598	PFAM Uncharacterised protein family UPF0150
BVWIN_RS03515	COG3561	AntA/AntB antirepressor
BVWIN_RS03545	COG0511	ligase activity, forming carbon-carbon bonds
BVWIN_RS03560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BVWIN_RS03565	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BVWIN_RS03575	COG1573	uracil-dna glycosylase
BVWIN_RS03585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BVWIN_RS03590	COG0557	exoribonuclease II activity
BVWIN_RS03595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BVWIN_RS03600	COG0758	DNA mediated transformation
BVWIN_RS03605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BVWIN_RS03610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BVWIN_RS03615	COG0540	Belongs to the ATCase OTCase family
BVWIN_RS03625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BVWIN_RS03630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BVWIN_RS03635	COG0154	amidase activity
BVWIN_RS03665	COG1278	Cold shock
BVWIN_RS03675	COG0596	Alpha beta hydrolase
BVWIN_RS03685	COG2003	Belongs to the UPF0758 family
BVWIN_RS03690	COG0024	Methionine aminopeptidase
BVWIN_RS03695	COG1489	DNA binding
BVWIN_RS03705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BVWIN_RS03710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BVWIN_RS03715	COG0037	tRNA processing
BVWIN_RS03720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BVWIN_RS03725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BVWIN_RS03750	COG1475	DNA binding
BVWIN_RS03795	COG3179	chitinase
BVWIN_RS03830	COG4373	Mu-like prophage FluMu protein gp28
BVWIN_RS03835	COG4383	Mu-like prophage protein gp29
BVWIN_RS03840	COG2369	cell adhesion
BVWIN_RS03960	COG1686	Belongs to the peptidase S11 family
BVWIN_RS03965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BVWIN_RS03980	COG0084	hydrolase, TatD family'
BVWIN_RS03985	COG0321	lipoyl(octanoyl) transferase activity
BVWIN_RS03985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BVWIN_RS04000	COG1183	phosphatidylcholine synthase activity
BVWIN_RS04005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BVWIN_RS04030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BVWIN_RS04035	COG0719	Fe-S assembly protein
BVWIN_RS04040	COG0396	ATPase activity
BVWIN_RS04045	COG0719	Fe-S assembly protein
BVWIN_RS04055	COG2945	thiolester hydrolase activity
BVWIN_RS04060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BVWIN_RS04065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BVWIN_RS04075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BVWIN_RS04080	COG0860	N-Acetylmuramoyl-L-alanine amidase
BVWIN_RS04085	COG1530	ribonuclease E activity
BVWIN_RS04100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BVWIN_RS04105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BVWIN_RS04110	COG1136	(ABC) transporter
BVWIN_RS04120	COG0442	prolyl-tRNA aminoacylation
BVWIN_RS04130	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BVWIN_RS04130	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BVWIN_RS04135	COG1007	ATP synthesis coupled electron transport
BVWIN_RS04150	COG0713	ATP synthesis coupled electron transport
BVWIN_RS04160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BVWIN_RS04165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BVWIN_RS04175	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BVWIN_RS04180	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BVWIN_RS04185	COG0649	NAD binding
BVWIN_RS04190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BVWIN_RS04195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BVWIN_RS04200	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BVWIN_RS04230	COG0302	gtp cyclohydrolase
BVWIN_RS04240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BVWIN_RS04245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BVWIN_RS04255	COG0776	regulation of translation
BVWIN_RS04260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BVWIN_RS04265	COG0416	fatty acid biosynthetic process
BVWIN_RS04280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BVWIN_RS04285	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BVWIN_RS04295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BVWIN_RS04295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BVWIN_RS04300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BVWIN_RS04305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BVWIN_RS04315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BVWIN_RS04320	COG1612	heme a metabolic process
BVWIN_RS04330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BVWIN_RS04335	COG1923	regulation of RNA biosynthetic process
BVWIN_RS04350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BVWIN_RS04360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BVWIN_RS04365	COG1063	alcohol dehydrogenase
BVWIN_RS04415	COG0071	Belongs to the small heat shock protein (HSP20) family
BVWIN_RS04465	COG0628	permease
BVWIN_RS04470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BVWIN_RS04475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BVWIN_RS04495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BVWIN_RS04505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BVWIN_RS04515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BVWIN_RS04520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BVWIN_RS04525	COG0047	phosphoribosylformylglycinamidine synthase activity
BVWIN_RS04530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BVWIN_RS04540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BVWIN_RS04545	COG2814	Major facilitator Superfamily
BVWIN_RS04550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BVWIN_RS04555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BVWIN_RS04560	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BVWIN_RS04565	COG0248	Ppx GppA phosphatase
BVWIN_RS04570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BVWIN_RS04580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BVWIN_RS04595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BVWIN_RS04600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BVWIN_RS04605	COG0785	Cytochrome C biogenesis protein
BVWIN_RS04615	COG0316	Belongs to the HesB IscA family
BVWIN_RS04620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BVWIN_RS04625	COG0018	arginyl-trna synthetase
BVWIN_RS04640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BVWIN_RS04660	COG0538	isocitrate dehydrogenase activity
BVWIN_RS04670	COG2814	Major facilitator Superfamily
BVWIN_RS04675	COG0343	queuine tRNA-ribosyltransferase activity
BVWIN_RS04690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BVWIN_RS04695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BVWIN_RS04710	COG0347	Belongs to the P(II) protein family
BVWIN_RS04715	COG0174	glutamine synthetase
BVWIN_RS04745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BVWIN_RS04750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BVWIN_RS04755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BVWIN_RS04760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BVWIN_RS04765	COG0203	ribosomal protein L17
BVWIN_RS04770	COG0202	RNA polymerase activity
BVWIN_RS04775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BVWIN_RS04780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BVWIN_RS04785	COG0563	adenylate kinase activity
BVWIN_RS04790	COG0201	protein transport
BVWIN_RS04795	COG0200	Binds to the 23S rRNA
BVWIN_RS04800	COG1841	ribosomal large subunit assembly
BVWIN_RS04805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BVWIN_RS04810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BVWIN_RS04815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BVWIN_RS04820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BVWIN_RS04825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BVWIN_RS04830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BVWIN_RS04835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BVWIN_RS04840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BVWIN_RS04845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BVWIN_RS04850	COG0255	Belongs to the universal ribosomal protein uL29 family
BVWIN_RS04855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BVWIN_RS04860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BVWIN_RS04865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BVWIN_RS04870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BVWIN_RS04875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BVWIN_RS04880	COG0089	rRNA binding
BVWIN_RS04885	COG0088	Forms part of the polypeptide exit tunnel
BVWIN_RS04890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BVWIN_RS04895	COG0051	transcription antitermination factor activity, RNA binding
BVWIN_RS04900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BVWIN_RS04905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BVWIN_RS04910	COG0049	tRNA binding
BVWIN_RS04915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BVWIN_RS04920	COG0708	Exodeoxyribonuclease III
BVWIN_RS04930	COG0765	amino acid transport
BVWIN_RS04935	COG0765	amino acid transport
BVWIN_RS04940	COG1126	abc transporter atp-binding protein
BVWIN_RS04945	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BVWIN_RS04950	COG0525	valine-tRNA ligase activity
BVWIN_RS04965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BVWIN_RS04980	COG3077	Addiction module antitoxin, RelB DinJ family
BVWIN_RS05000	COG3210	domain, Protein
BVWIN_RS05025	COG1999	signal sequence binding
BVWIN_RS05035	COG0006	proline dipeptidase activity
BVWIN_RS05040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BVWIN_RS05050	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BVWIN_RS05065	COG0849	cell division
BVWIN_RS05075	COG1181	Belongs to the D-alanine--D-alanine ligase family
BVWIN_RS05080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BVWIN_RS05085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BVWIN_RS05090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BVWIN_RS05100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BVWIN_RS05105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BVWIN_RS05115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BVWIN_RS05125	COG5462	secreted (periplasmic) protein
BVWIN_RS05130	COG0275	rRNA processing
BVWIN_RS05135	COG0741	lytic transglycosylase activity
BVWIN_RS05145	COG2226	methyltransferase
BVWIN_RS05160	COG1335	isochorismatase
BVWIN_RS05205	COG2968	Membrane
BVWIN_RS05215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BVWIN_RS05225	COG0668	transmembrane transport
BVWIN_RS05250	COG3161	chorismate lyase activity
BVWIN_RS05255	COG0505	Belongs to the CarA family
BVWIN_RS05275	COG1278	Cold shock
BVWIN_RS05280	COG0436	Aminotransferase
BVWIN_RS05285	COG0583	DNA-binding transcription factor activity
BVWIN_RS05290	COG0492	ferredoxin-NADP+ reductase activity
BVWIN_RS05295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BVWIN_RS05305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BVWIN_RS05315	COG0556	nucleotide-excision repair
BVWIN_RS05325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BVWIN_RS05330	COG0745	RESPONSE REGULATOR receiver
BVWIN_RS05350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BVWIN_RS05360	COG1496	oxidoreductase activity
BVWIN_RS05380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BVWIN_RS05385	COG0193	aminoacyl-tRNA hydrolase activity
BVWIN_RS05390	COG1376	ErfK ybiS ycfS ynhG family protein
BVWIN_RS05395	COG0012	GTP binding
BVWIN_RS05415	COG0723	plastoquinol--plastocyanin reductase activity
BVWIN_RS05420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BVWIN_RS05425	COG0617	tRNA 3'-terminal CCA addition
BVWIN_RS05430	COG0714	Associated with various cellular activities
BVWIN_RS05450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BVWIN_RS05455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BVWIN_RS05465	COG0482	sulfurtransferase activity
BVWIN_RS05540	COG0444	Belongs to the ABC transporter superfamily
BVWIN_RS05545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BVWIN_RS05550	COG0601	transmembrane transport
BVWIN_RS05555	COG0747	negative chemotaxis
BVWIN_RS05560	COG0747	negative chemotaxis
BVWIN_RS05565	COG0519	Catalyzes the synthesis of GMP from XMP
BVWIN_RS05570	COG1570	exodeoxyribonuclease VII activity
BVWIN_RS05590	COG0730	response to heat
BVWIN_RS05600	COG2086	electron transfer activity
BVWIN_RS05625	COG0792	nuclease activity
BVWIN_RS05630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BVWIN_RS05635	COG0489	protein tyrosine kinase activity
BVWIN_RS05640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BVWIN_RS05645	COG0594	ribonuclease P activity
BVWIN_RS05655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BVWIN_RS05670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BVWIN_RS05675	COG0588	phosphoglycerate mutase activity
BVWIN_RS05700	COG3561	AntA/AntB antirepressor
BVWIN_RS05755	COG3561	AntA/AntB antirepressor
BVWIN_RS05760	COG1598	PFAM Uncharacterised protein family UPF0150
BVWIN_RS05770	COG0629	single-stranded DNA binding
BVWIN_RS05810	COG3561	AntA/AntB antirepressor
BVWIN_RS05815	COG3561	AntA/AntB antirepressor
BVWIN_RS05875	COG3561	AntA/AntB antirepressor
BVWIN_RS06005	COG3657	addiction module killer protein
BVWIN_RS06040	COG3561	AntA/AntB antirepressor
BVWIN_RS06060	COG3561	AntA/AntB antirepressor
BVWIN_RS06065	COG0582	viral genome integration into host DNA
BVWIN_RS06100	COG2814	Major facilitator Superfamily
BVWIN_RS06170	COG0735	belongs to the Fur family
BVWIN_RS06195	COG1054	Belongs to the UPF0176 family
BVWIN_RS06220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BVWIN_RS06220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BVWIN_RS06225	COG0509	glycine decarboxylation via glycine cleavage system
BVWIN_RS06230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BVWIN_RS06240	COG2835	tetraacyldisaccharide 4'-kinase activity
BVWIN_RS06245	COG1396	sequence-specific DNA binding
BVWIN_RS06250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BVWIN_RS06265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BVWIN_RS06270	COG2011	ABC-type metal ion transport system permease component
BVWIN_RS06300	COG0523	cobalamin synthesis protein
BVWIN_RS06350	COG4607	ABC-type enterochelin transport system periplasmic component
BVWIN_RS06355	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BVWIN_RS06360	COG4605	iron ion homeostasis
BVWIN_RS06365	COG4604	ABC transporter, ATP-binding protein
BVWIN_RS06470	COG1192	Involved in chromosome partitioning
BVWIN_RS06485	COG0196	riboflavin kinase activity
BVWIN_RS06505	COG3838	Conjugal transfer protein Trbc
BVWIN_RS06510	COG3702	type iv secretory pathway
BVWIN_RS06515	COG3451	type IV secretory pathway VirB4
BVWIN_RS06525	COG3704	protein secretion by the type IV secretion system
BVWIN_RS06535	COG3736	Type IV secretory pathway, component VirB8
BVWIN_RS06540	COG3504	Conjugal transfer protein
BVWIN_RS06545	COG2948	multi-organism process
BVWIN_RS06550	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BVWIN_RS06560	COG2184	nucleotidyltransferase activity
BVWIN_RS06565	COG2184	nucleotidyltransferase activity
BVWIN_RS06570	COG3505	Type IV secretory pathway VirD4
BVWIN_RS06580	COG2184	nucleotidyltransferase activity
BVWIN_RS06615	COG0728	peptidoglycan biosynthetic process
BVWIN_RS06620	COG0180	Tryptophanyl-tRNA synthetase
BVWIN_RS06630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BVWIN_RS06650	COG0459	protein refolding
BVWIN_RS06655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BVWIN_RS06675	COG0124	histidyl-tRNA synthetase
BVWIN_RS06770	COG0784	Response regulator, receiver
BVWIN_RS06865	COG1396	sequence-specific DNA binding
BVWIN_RS06875	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BVWIN_RS06880	COG0424	maF-like protein
BVWIN_RS06885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BVWIN_RS06890	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BVWIN_RS06900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BVWIN_RS06910	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BVWIN_RS06920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BVWIN_RS06925	COG0457	Tetratricopeptide repeat
BVWIN_RS06935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BVWIN_RS06940	COG1692	metallophosphoesterase
BVWIN_RS06945	COG1396	sequence-specific DNA binding
BVWIN_RS06955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BVWIN_RS07125	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BVWIN_RS07135	COG1238	metal cluster binding
BVWIN_RS07160	COG0756	dUTP diphosphatase activity
BVWIN_RS07165	COG0848	biopolymer transport protein
BVWIN_RS07170	COG0811	peptide transport
BVWIN_RS07190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BVWIN_RS07195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BVWIN_RS07200	COG0037	tRNA processing
BVWIN_RS07210	COG2885	chlorophyll binding
BVWIN_RS07220	COG0217	transcriptional regulatory protein
BVWIN_RS07225	COG0823	Involved in the tonB-independent uptake of proteins
BVWIN_RS07245	COG0824	Thioesterase
BVWIN_RS07250	COG2255	four-way junction helicase activity
BVWIN_RS07255	COG0632	four-way junction helicase activity
BVWIN_RS07260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BVWIN_RS07265	COG1396	sequence-specific DNA binding
BVWIN_RS07305	COG1396	sequence-specific DNA binding
BVWIN_RS07315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BVWIN_RS07320	COG0483	inositol monophosphate 1-phosphatase activity
BVWIN_RS07335	COG1132	(ABC) transporter
BVWIN_RS07340	COG0254	rRNA binding
BVWIN_RS07345	COG3588	fructose-bisphosphate aldolase
BVWIN_RS07350	COG0126	phosphoglycerate kinase activity
BVWIN_RS07385	COG0469	pyruvate kinase activity
BVWIN_RS07395	COG3750	Belongs to the UPF0335 family
BVWIN_RS07410	COG0488	(ABC) transporter
BVWIN_RS07430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BVWIN_RS07440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BVWIN_RS07450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BVWIN_RS07455	COG0142	geranyltranstransferase activity
BVWIN_RS07465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BVWIN_RS07480	COG1566	PFAM secretion protein HlyD family protein
BVWIN_RS07490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BVWIN_RS07495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BVWIN_RS07500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BVWIN_RS07505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BVWIN_RS07510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BVWIN_RS07520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BVWIN_RS07530	COG0495	leucyl-tRNA aminoacylation
BVWIN_RS07550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BVWIN_RS07555	COG2884	Cell division ATP-binding protein ftsE
BVWIN_RS07570	COG0577	efflux transmembrane transporter activity
BVWIN_RS07570	COG1136	(ABC) transporter
BVWIN_RS07575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BVWIN_RS07595	COG1674	ftsk spoiiie
BVWIN_RS07600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BVWIN_RS07665	COG3704	protein secretion by the type IV secretion system
BVWIN_RS07680	COG3704	protein secretion by the type IV secretion system
BVWIN_RS07695	COG3704	protein secretion by the type IV secretion system
BVWIN_RS07710	COG3504	Conjugal transfer protein
BVWIN_RS07745	COG0335	large ribosomal subunit rRNA binding
BVWIN_RS07750	COG0336	Belongs to the RNA methyltransferase TrmD family
BVWIN_RS07755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BVWIN_RS07795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BVWIN_RS07805	COG0138	bifunctional purine biosynthesis protein purh
BVWIN_RS07815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BVWIN_RS07815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BVWIN_RS07820	COG0501	Belongs to the peptidase M48B family
BVWIN_RS07830	COG0228	four-way junction DNA binding
BVWIN_RS07840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BVWIN_RS07845	COG0288	reversible hydration of carbon dioxide
BVWIN_RS07850	COG2902	Dehydrogenase
BVWIN_RS07860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BVWIN_RS07875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BVWIN_RS07885	COG0745	RESPONSE REGULATOR receiver
BVWIN_RS07920	COG1671	Belongs to the UPF0178 family
BVWIN_RS07930	COG0287	Prephenate dehydrogenase
BVWIN_RS07940	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BVWIN_RS07995	COG1475	DNA binding
BVWIN_RS08020	COG0351	phosphomethylpyrimidine kinase
BVWIN_RS08030	COG1686	Belongs to the peptidase S11 family
BVWIN_RS08040	COG3034	peptidoglycan biosynthetic process
BVWIN_RS08045	COG0825	malonyl-CoA metabolic process
BVWIN_RS08055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BVWIN_RS08060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BVWIN_RS08075	COG1320	monovalent cation:proton antiporter activity
BVWIN_RS08080	COG2212	antiporter activity
BVWIN_RS08090	COG0651	ATP synthesis coupled electron transport
BVWIN_RS08095	COG1006	Multisubunit Na H antiporter MnhC subunit
BVWIN_RS08100	COG2111	Na H antiporter
BVWIN_RS08100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BVWIN_RS08110	COG0019	diaminopimelate decarboxylase activity
BVWIN_RS08130	COG0567	Dehydrogenase, E1 component
BVWIN_RS08140	COG0045	succinate-CoA ligase (ADP-forming) activity
BVWIN_RS08145	COG0039	L-malate dehydrogenase activity
BVWIN_RS08150	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BVWIN_RS08160	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BVWIN_RS08165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BVWIN_RS08170	COG0552	protein localization to endoplasmic reticulum
BVWIN_RS08175	COG2917	probably involved in intracellular septation
BVWIN_RS08180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BVWIN_RS08200	COG0357	Ribosomal RNA small subunit methyltransferase G
BVWIN_RS08205	COG0445	tRNA wobble uridine modification
BVWIN_RS08210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BVWIN_RS08215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template